JP2004350780A - System and method for promoting metabolism of human skin - Google Patents
System and method for promoting metabolism of human skin Download PDFInfo
- Publication number
- JP2004350780A JP2004350780A JP2003149736A JP2003149736A JP2004350780A JP 2004350780 A JP2004350780 A JP 2004350780A JP 2003149736 A JP2003149736 A JP 2003149736A JP 2003149736 A JP2003149736 A JP 2003149736A JP 2004350780 A JP2004350780 A JP 2004350780A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- vitamin
- metabolism
- human skin
- promoting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 15
- 230000004060 metabolic process Effects 0.000 title claims abstract description 13
- 230000001737 promoting effect Effects 0.000 title claims abstract description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 64
- 210000003491 skin Anatomy 0.000 claims abstract description 48
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 26
- 239000011718 vitamin C Substances 0.000 claims abstract description 26
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 26
- 210000002510 keratinocyte Anatomy 0.000 claims abstract description 15
- 210000002615 epidermis Anatomy 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims description 15
- 238000002604 ultrasonography Methods 0.000 claims description 9
- 239000000232 Lipid Bilayer Substances 0.000 claims description 6
- 229960005070 ascorbic acid Drugs 0.000 claims description 5
- 235000000069 L-ascorbic acid Nutrition 0.000 claims description 4
- 239000002211 L-ascorbic acid Substances 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 230000000368 destabilizing effect Effects 0.000 claims 2
- 150000002596 lactones Chemical class 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 1
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 22
- 230000019612 pigmentation Effects 0.000 abstract 2
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 230000003716 rejuvenation Effects 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 208000012641 Pigmentation disease Diseases 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 210000002752 melanocyte Anatomy 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 206010061765 Chromosomal mutation Diseases 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 108010050808 Procollagen Proteins 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 108091092356 cellular DNA Proteins 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 231100000707 mutagenic chemical Toxicity 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
Images
Landscapes
- Cosmetics (AREA)
Abstract
Description
【0001】
【発明の属する技術分野】
本発明は、皮膚層又はその他の生体膜素材層の代謝促進に関する。本方法では、超音波装置を用いて化学システムを皮膚層に供給する。皮層を通過して化学システムが供給されると、本システムは皮膚の新陳代謝を促進する。
【0002】
【従来の技術】
物質を皮膚を通過させて血流に到達させる方法は、医療分野においてよく知られている。一般に、超音波導入法、つまり物質を皮膚に注入する行為は、物質を血流に取り込むための周知の方法である。通常、化学促進剤の使用、すなわち物質が透過促進剤によって皮膚に取り込まれる行為は、物質が皮膚へ透過するのを容易にするために用いられる。
【0003】
さらに、化粧品や皮膚用製品の利用者は、美白や皮膚の若返りをますます求めている。美白の試みは、一般的に、利用者の皮膚の一部が他の部分よりも色濃い場合に、全般的な皮膚の色素沈着を修復したいという願望に基づき行われる。皮膚の若返りと美白は年齢に起因するばかりでなく、太陽や他の放射線の照射による場合もある。美白や皮膚を若返らせる試みはいくつもあった。もっとも一般的な方法においては、各種ビタミンやミネラルのローションを利用する。すなわち、ビタミンCは、局部において人体の新陳代謝を促進することが当該技術分野において良く知られており、これによって体が回復し、癒えるのである。
【0004】
【発明が解決しようとする課題】
残念ながら、これらの一般的に知られているローションは局所的に、表皮の上に塗布されるものであり、表皮の下にあるもっとも重要な皮膚層である真皮層にビタミンやミネラルを効果的に供給することができない。
【0005】
【課題を解決するための手段】
本発明は美白及び皮膚を若返らせる方法を提供するものであり、皮膚の真皮層にビタミンやミネラルを直接供給するために設計された化学システムを用いる工程と、超音波導入法で用いられる装置と同様の超音波装置を使用する工程とを備える。
【0006】
さらに、本発明の利点は、化学システムで供給されたビタミンとミネラルを皮膚の真皮層に能動的に供給するために、化学システムと超音波装置を活用する方法を提供することであり、それにより皮膚の若返りを促進する。
【0007】
【発明の実施の形態】
第1図に示すケラチノサイト群50は、人体の辺縁にある第一の障壁である表皮60の一部である。より具体的には、ケラチノサイト群50は、有害な紫外線から人体を保護するために、体の皮膚色の調整に役立つ。ケラチノサイト群50は人体に信号を送り、この信号が人体に有害な状況を伝えることによって、当該保護を行う。
【0008】
第2図に示すように、有害な状況の通知を受けると、人体は新陳代謝を増加させることによって反応し、その結果、メラノサイト80からメラニン70が分泌される。メラニン70は、太陽の自然光から人体を保護する唯一の物質である。メラニン70は高い光学濃度を有し、影響を及ぼす紫外線を吸収し、散乱させることができる。その後、メラニン70はケラチノサイト群50によって収集され、その中に保存される。メラニンの高い光学濃度により、ケラチノサイト50内のメラニン70の保存量が増加するにつれて、皮膚の色素沈着はより濃くなる。
【0009】
第3図に示すヒト皮膚の代謝促進システムの代表的な実施例は、皮膚の表面上又は近接して超音波装置30が配置され、1メガヘルツ〜3メガヘルツの規模の周波数を有する超音波を共振するものである。超音波が皮膚の真皮層と出会うと、脂質二重層は超音波を吸収しはじめる。超音波を吸収することで、脂質二重層内の細胞は移動して、不安定化し、それによってエアポケットが出来、微粒子素材が皮膚層を通過することが可能になる。このプロセスは超音波導入法として当該技術分野においてはよく知られている。
【0010】
超音波導入法によって、超音波装置を用いて5μm〜200μmの微粒子の通過が可能になると、L−アスコルビン酸(L−3−ケトトレオヘキスロン酸ラクトン)などの液状のビタミンCを皮膚の表皮層60内に挿入することが可能になり、それにより液状のビタミンCは皮膚の表皮層内に保存されているケラチノサイト群50と接触する。液状のビタミンCを皮膚内に挿入し、ビタミンCをケラチノサイト群50に供給する工程は、液状のビタミンCを皮膚に塗布して被覆部を形成し、液状のビタミンCの被覆部を含む皮膚に超音波装置を手動で1分〜5分間近接させることによって達成される。脂質二重層(図示しない)が解体された時点で、液状のビタミンCは脂質二重層を通過して皮膚の表皮層まで達することができ、それによって液状のビタミンCをケラチノサイト群50に供給できる。ビタミンCはアスコルビン酸であり、細胞レベルで作用し、メラニン70などのプロコラーゲン分子を細胞から運び出す機能を提供する。ケラチノサイト群50内のメラニン70を運び出す結果として、皮膚色素沈着が回復する。
【0011】
ビタミンCを皮膚細胞に直接供給する他の利点は、ビタミンCが細胞及びその構造にもたらす良い結果である。ビタミンCは、細胞のDNAをフリーラジカルや突然変異原による損傷から保護する。ビタミンCは、細胞内の有害な遺伝子組換えを防止し、染色体への突然変異からリンパ球を保護する。ビタミンCは、オゾン、一酸化炭素、炭化水素、農薬及び重金属を含む多くの毒素の影響に対抗して皮膚を修復するので、環境汚染が広範囲に及ぶ今日において、特に重要と思われる。
【図面の簡単な説明】
【図1】通常のケラチノサイトを示す図である。
【図2】ケラチノサイトがメラノサイトからメラニンを取得している様子を示す図である。
【図3】本発明を示す図である。[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to the promotion of metabolism of skin layers or other biomembrane material layers. In the method, an ultrasonic device is used to deliver the chemical system to the skin layer. As the chemical system is delivered through the cortex, the system promotes skin metabolism.
[0002]
[Prior art]
Methods for passing substances through the skin to reach the bloodstream are well known in the medical arts. In general, ultrasound delivery, or the act of injecting a substance into the skin, is a well-known method for incorporating a substance into the bloodstream. Usually, the use of chemical enhancers, ie, the act of incorporating a substance into the skin by a permeation enhancer, is used to facilitate the penetration of the substance into the skin.
[0003]
In addition, users of cosmetics and dermatological products are increasingly seeking whitening and skin rejuvenation. Skin lightening attempts are generally based on the desire to restore general skin pigmentation when some parts of the user's skin are darker than others. Skin rejuvenation and whitening are not only due to age, but can also be due to exposure to the sun or other radiation. There have been several attempts to whiten and rejuvenate the skin. The most common method utilizes lotions of various vitamins and minerals. That is, it is well known in the art that vitamin C locally promotes the metabolism of the human body, thereby recovering and healing the body.
[0004]
[Problems to be solved by the invention]
Unfortunately, these commonly known lotions are applied topically, over the epidermis, and effectively remove vitamins and minerals from the dermal layer, the most important skin layer under the epidermis. Can not be supplied.
[0005]
[Means for Solving the Problems]
The present invention provides a method for whitening and rejuvenating the skin, using a chemical system designed to directly supply vitamins and minerals to the dermis layer of the skin, and an apparatus used in the ultrasonic introduction method. Using a similar ultrasonic device.
[0006]
Further, an advantage of the present invention is that it provides a method of utilizing a chemical system and an ultrasound device to actively deliver the vitamins and minerals provided by the chemical system to the dermis layer of the skin, whereby Promotes skin rejuvenation.
[0007]
BEST MODE FOR CARRYING OUT THE INVENTION
The
[0008]
As shown in FIG. 2, when notified of a harmful situation, the human body responds by increasing metabolism, resulting in the secretion of melanin 70 from
[0009]
An exemplary embodiment of the system for promoting metabolism of human skin shown in FIG. 3 includes an ultrasonic device 30 disposed on or near the surface of the skin to resonate ultrasonic waves having a frequency on the order of 1 to 3 MHz. Is what you do. When the ultrasound encounters the dermis layer of the skin, the lipid bilayer begins to absorb the ultrasound. By absorbing the ultrasound, the cells within the lipid bilayer move and become destabilized, thereby creating air pockets and allowing particulate material to pass through the skin layer. This process is well known in the art as an ultrasound introduction method.
[0010]
When the ultrasonic introduction method allows the passage of fine particles of 5 μm to 200 μm using an ultrasonic device, a liquid vitamin C such as L-ascorbic acid (L-3-ketothreohexuronic acid lactone) is applied to the epidermis of the skin. It can be inserted into the layer 60, whereby the liquid vitamin C comes into contact with the
[0011]
Another advantage of supplying vitamin C directly to skin cells is the positive consequences of vitamin C on cells and their structure. Vitamin C protects cellular DNA from damage by free radicals and mutagens. Vitamin C prevents harmful genetic modification in cells and protects lymphocytes from chromosomal mutations. Vitamin C appears to be particularly important in today's widespread environmental pollution as it repairs the skin against the effects of many toxins, including ozone, carbon monoxide, hydrocarbons, pesticides and heavy metals.
[Brief description of the drawings]
FIG. 1 is a diagram showing normal keratinocytes.
FIG. 2 is a diagram showing a state in which keratinocytes are acquiring melanin from melanocytes.
FIG. 3 is a diagram showing the present invention.
Claims (8)
5μm〜200μmの粒径からなる液状のビタミンCと、
を備え、
前記超音波装置が皮膚の脂質二重層を不安定化することが可能であることを特徴とする、ヒト皮膚の代謝促進システム。An ultrasound device capable of generating ultrasound having a frequency on the order of 1 to 3 megahertz and capable of being placed in close proximity to the surface of the skin;
A liquid vitamin C having a particle size of 5 μm to 200 μm;
With
A system for promoting metabolism of human skin, wherein the ultrasonic device is capable of destabilizing a lipid bilayer of skin.
皮膚の表皮層に液状のビタミンCを挿入する工程と、
前記皮膚の表皮層に位置するケラチノサイト群にビタミンCを供給する工程と
を備えるヒト皮膚の代謝促進方法。Destabilizing the lipid bilayer of the skin using an ultrasound device,
Inserting liquid vitamin C into the epidermal layer of the skin;
Supplying vitamin C to the keratinocyte group located in the epidermal layer of the skin.
前記液状のビタミンCの被覆部を含む皮膚に超音波装置を手動で近接させる工程と
を備えるヒト皮膚の代謝促進方法。Forming a coating by applying liquid vitamin C to the skin;
Manually bringing an ultrasonic apparatus close to the skin containing the liquid vitamin C coating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003149736A JP2004350780A (en) | 2003-05-27 | 2003-05-27 | System and method for promoting metabolism of human skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003149736A JP2004350780A (en) | 2003-05-27 | 2003-05-27 | System and method for promoting metabolism of human skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2004350780A true JP2004350780A (en) | 2004-12-16 |
Family
ID=34045753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003149736A Pending JP2004350780A (en) | 2003-05-27 | 2003-05-27 | System and method for promoting metabolism of human skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2004350780A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008125577A (en) * | 2006-11-17 | 2008-06-05 | Eisuke Imanaga | Medicinal component delivery system, cup for operation and composition containing medicinal component |
-
2003
- 2003-05-27 JP JP2003149736A patent/JP2004350780A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008125577A (en) * | 2006-11-17 | 2008-06-05 | Eisuke Imanaga | Medicinal component delivery system, cup for operation and composition containing medicinal component |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20030212129A1 (en) | System and method for revitalizing human skin | |
| US20230118736A1 (en) | Generating cold plasma away from skin, and associated systems and methods | |
| EP3030180B1 (en) | Apparatus for use with energy activatible materials | |
| JP6974265B2 (en) | A composition containing an energy absorbing material for hair follicle delivery and a method for delivering the same. | |
| Benson et al. | Topical and transdermal drug delivery: principles and practice | |
| US11612433B2 (en) | Laser-assisted transdermal delivery of nanoparticulates and hydrogels | |
| Nguyen et al. | Electrically and ultrasonically enhanced transdermal delivery of methotrexate | |
| US7427273B2 (en) | Skin beautification cosmetic system using iontophoresis device, ultrasonic facial stimulator, and cosmetic additive | |
| EP3091919B1 (en) | Treatment intervals for use of compositions comprising energy absorbing materials for dermatological applications | |
| CN112512449A (en) | Cold plasma generation device, system and method | |
| Nanda et al. | Current developments using emerging transdermal technologies in physical enhancement methods. | |
| CN101128136A (en) | Method of treating skin with benefit agents and devices | |
| US20040219179A1 (en) | Skin abrasive agents | |
| CN109561916A (en) | Barotropic flow dermabrasion system and method for making skin rejuvenate | |
| Leonida et al. | Bionanomaterials for skin regeneration | |
| Lio et al. | Temporal pressure enhanced topical drug delivery through micropore formation | |
| Xin et al. | Transdermal delivery of topical lidocaine in a mouse model is enhanced by treatment with cold atmospheric plasma | |
| Alsaad et al. | A split face study to document the safety and efficacy of clearance of melasma with a 5 ns q switched Nd YAG laser versus a 50 ns q switched Nd YAG laser | |
| WO2021030280A1 (en) | Methods and compositions for treating dermatological conditions before, during, and/or after electromagnetic radiation treatment | |
| Paasch | The future of fractional lasers | |
| Atkinson et al. | Targets in dermal and transdermal delivery and classification of penetration enhancement methods | |
| JP2004350780A (en) | System and method for promoting metabolism of human skin | |
| Upasani et al. | Innovations and future prospects of dermal delivery systems | |
| Kwon et al. | Effect of cosmetic ingredients as functional agents: synergistic action of electroporation and sonophoresis in clinical efficacy | |
| Levenberg et al. | Case Series: Therapeutic Combination of VoluDerm Radiofrequency Microneedling and Glycolic Acid Peel in Scaled-Up Concentrations |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20050311 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20050311 |
|
| A521 | Written amendment |
Effective date: 20050510 Free format text: JAPANESE INTERMEDIATE CODE: A523 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060518 |
|
| A131 | Notification of reasons for refusal |
Effective date: 20090407 Free format text: JAPANESE INTERMEDIATE CODE: A131 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20090409 |
|
| A02 | Decision of refusal |
Effective date: 20091001 Free format text: JAPANESE INTERMEDIATE CODE: A02 |