JP2004091485A - Vitamin b1 containing nutritive composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a nutritive composition capable of feeding nourishment without restriction of dosage energy by raising rate of in vivo vitamin fullness and ameliorating the increase in blood sugar level of a patient requiring oral or enteral nutritional supply, especially a patient for digestive organ medical operation or aged person easy to fall into glucose tolerance disorder. <P>SOLUTION: This nutritive composition comprises proteins, carbohydrates and lipids as principal components and vitamins and minerals, and the composition comprises 4-11 mg of vitamin B1 per 100 kcal of the nutritive composition. <P>COPYRIGHT: (C)2004,JPO

Description

The present invention relates to a nutritional composition to be administered to a surgical patient, an elderly person, or a malnourished patient requiring oral or enteral nutritional supplementation. More specifically, the present invention is a nutritional composition containing 0.5 to 2.0 kcal / mL, preferably 1.0 to 1.6 kcal / mL, which contains protein, lipid, and saccharide as main components and contains vitamins and minerals.

Enteral nutrition includes oral nutrition and forced enteral nutrition, such as nasogastric or naso-intestinal tract, gastric fistula and intestinal fistula, depending on the administration route. Enteral nutrients are classified into component nutrients, digestive or semi-digestive nutrients, natural concentrated liquid foods, and the like, depending on the difference in the form of the nitrogen source and the necessity of intraluminal digestion. Enteral nutrition is more physiological than parenteral nutrition and is used for nutritional management of cancer patients, severe burns, upper gastrointestinal tract obstruction and intestinal insufficiency.・ It is used for nutrition management of postoperative patients. In addition, enteral nutrition is recommended for elderly people or those who have low consumption such as post-sick people, those who have reduced swallowing ability, those who have difficulty in swallowing training, and those who have poor oral intake in patients with limited water intake. Although liquid nutritional supplements are mainly used in the present invention, not only liquid nutritional supplements but also gel nutritional supplements are similarly used. In other words, when the chewing power is weak, the food is finely chopped or crushed, and when the swallowing function is weak, the food is eaten depending on the jelly-like or paste-like form, the chewing power, and the degree of the swallowing function. Since nutritional forms to be taken are different, various forms of nutritional compositions, such as liquid or gel, are widely used for people in need of nutrition.
In gastrointestinal surgery patients and the elderly, prolonged inadequate intake of proteins, energy, vitamins, minerals, etc. may lead to a decrease in immune function and the onset of new diseases. In particular, vitamins are one of the indispensable nutrients for living a healthy life, and their coenzyme action, metabolic regulation action, etc. were known, but in addition, antioxidant action, intercellular information It has been found that there is an action other than nutrients such as a transmission action. Therefore, it is important to take proper amounts of vitamins.
The amount of the conventional nutritional supplement or nutritional composition is set so that the required daily amount of vitamins can be satisfied when the energy requirement of the aged is administered. Therefore, when the energy dose is small, the vitamin is in a state of insufficient intake.

In recent years, liquid foods fortified with vitamins and minerals have been sold (trade names NT-3, NT-5, OKUNOS: Harmonic-M, S.S.Ajinomoto Pharma). Patent Literature 1 proposes a nutrition porridge in which pulverized cereals are mixed with a liquid nutritional composition containing proteins, vitamins, and minerals. Nutritionally, it is said that these liquid foods or nutrient porridge can supply nutrients required for vitamins and minerals by ingesting 1000 kcal of energy. However, vitamin B1 contained in these liquid foods is 0.18 to 0.88 mg per 100 kcal of energy, and vitamin B1 contained in nutrient porridge is about 0.03 to 0.4 mg, and when these liquid meals or nutrient porridge are ingested No studies have been made on the blood vitamin concentration of the lipase.
Vitamin B1 acts as a coenzyme in the form of thiamine 2-phosphate (TPP) as a coenzyme in the decarboxylation reaction of α-keto acid and in the transketolase reaction between hexose and pentose phosphate, and acts as a sugar and branched-chain amino acid. Participates in the metabolism of
After absorption, vitamin B2 is converted to coenzyme type flavin adenine dinucleotide or flavin mononucleotide, and acts in energy metabolism and many redox systems.
Vitamin B6 functions as a coenzyme such as transaminase and decarboxylase related to amino acid metabolism.
JP 2000-300194 A

When surgical invasion is added to a living body by gastrointestinal surgery or the like, an increase in tissue vitamin demand due to promotion of turnover under invasion after surgery increases. In addition, secretion of epinephrine, steroid hormones, glucagon and the like is enhanced. In addition, insulin secretion from the pancreas is not significantly suppressed, but epinephrine inhibits insulin action in peripheral tissues. That is, the use of sugar is impaired after the operation, resulting in a kind of diabetes-like state. Because the impaired sugar utilization is not due to impaired insulin secretion but due to the impaired action of insulin in peripheral tissues, administration of exogenous insulin does not respond (Basic postoperative metabolism and clinical practice, Shinko Trading Medical Books) . That is, in the early postoperative period, hyperglycemia is likely to occur, and the amount of administered energy is limited.
The main object of the present invention is to provide a vitamin-deficient patient before and after surgery, a diabetic patient, or an elderly person, who has a sufficient amount of vitamins even if the required energy dose is as small as 1/5 to 1/10. It is to provide a nutritional composition that can be replenished in quantity.
Another object of the present invention is to increase the body's vitamin sufficiency and increase the blood glucose level in patients requiring oral or enteral nutritional supplementation, especially in gastrointestinal surgery patients and elderly people who are prone to impaired glucose tolerance. It is an object of the present invention to provide a nutritional composition capable of supplementing nutrients that cannot be taken only with meals, for the purpose of suppressing illness, increasing body weight, and improving serum albumin concentration.

The object of the present invention is solved by the following means.
(1) A nutritional composition containing proteins, carbohydrates, and lipids as main components and containing vitamins and minerals, wherein the nutritional composition contains 4 mg or more of vitamin B1 per 100 kcal of the nutritional composition.
(2) The nutritional composition according to the above (1), wherein the vitamin B1 content is 11 mg or less per 100 kcal of the nutritional composition.
(3) The nutritional composition according to the above (1) or (2), comprising 0.1 to 12 mg of vitamin B2 and 0.12 to 16 mg of vitamin B6 per 100 kcal of the nutritional composition.
(4) The nutritional composition according to any one of (1) to (3) above, which contains 0.13 to 24 μg of vitamin B12, 6 to 1000 mg of vitamin C, and 10 to 1000 μg of folic acid per 100 kcal of the nutritional composition.
(5) The nutritional composition according to any one of the above (1) to (4), which contains vitamins in the following proportions per 100 kcal of the nutritional composition.
Vitamin K 120-2000μg
Nicotinamide 1-30mg
Pantothenic acid 0.3-50mg
Vitamin A 120-5000IU
Vitamin D 10-2000 IU
Vitamin E 0.6-600IU
(6) The nutritional composition according to any one of the above (1) to (5), which has an energy of 0.5 to 2.0 kcal / mL, preferably 1.0 to 1.6 kcal / mL.
(7) The nutritional composition according to any one of (1) to (6) above, wherein the viscosity of the nutritional composition is in a range of 5 to 40 mPa · s (25 ° C.).
(8) The nutritional composition according to any one of the above (1) to (6), wherein the nutritional composition has a gel strength in a range of 1 × 10 ² to 1 × 10 ⁵ N / m ² . .

The present invention is a nutritional composition containing proteins, carbohydrates, and lipids as main components and containing vitamins and minerals. It can maintain high levels of middle vitamin B1 and can moderately increase blood sugar, so patients who need oral or enteral nutrition, especially those who have impaired glucose tolerance It is possible to provide a nutritional composition that can provide nutritional support to gastrointestinal surgery patients and the elderly by increasing the body's vitamin sufficiency rate and slowing the increase in blood sugar level without limiting the administration energy. In patients with potentially vitamin deficient pre- and post-surgical patients, diabetics, and the elderly, even small doses of 1/5 to 1/10 of the required energy Min can provide a sufficient amount of replenishing nutritional composition.

The present inventors have conducted intensive studies to solve the above problems, and found that the maximum amount of vitamin B1 contained in conventional nutritional compositions and the like was 0.88 mg per 100 kcal of energy. Was found to be unsuitable for the intended use. As a result of further study, when the vitamin B1 content in the nutritional composition is 4 mg / 100 kcal or more, it is possible to maintain the blood vitamin B1 concentration at a high value, and further suppress the increase in blood sugar level, increase the weight, The present inventors have obtained a new finding that the serum albumin concentration can be increased, and have completed the present invention.
In addition, vitamin B1 holding capacity may be reduced in elderly people, and continuous supplementation is necessary to maintain good B1 nutritional status. Fits the purpose.
Since this vitamin B1 is a water-soluble vitamin and is rapidly excreted in urine even if it is ingested excessively, the upper limit is not set for the amount of vitamin B1 from the above viewpoint, but it is unique to vitamin B1. For example, when the composition is set so that masking cannot be performed sufficiently, excessive blending may not be preferable for reasons of formulation as a nutritional composition. Further, the body odor of the patient who has taken the nutritional composition may have a vitamin B1 odor, which may be unpleasant, and an excessive combination may not be preferable from the viewpoint of QOL. Furthermore, it is not economically preferable to mix vitamin B1 that is excreted without being used by the patient, and from these points, the upper limit is preferably 11 mg / 100 kcal.

The nutritional composition of the present invention, in a liquid form such as a liquid food, contains proteins, carbohydrates, lipids, vitamins and minerals, and has an energy of 0.5 to 2.0 kcal / mL, with a preferred range of 1.0 to 1.6 kcal / mL. is there. Regarding the administration route, a nasogastric tube, a nasal intestinal tube, a gastric fistula, and an intestinal fistula using a tube can be considered. The viscosity is 5 to 40 mPa · S · 25 ° C., the preferred range is 10 to 30 mPa · S · 25 ° C., and a tube having good fluidity is preferable. In addition, the gel-like nutritional composition contains proteins, carbohydrates, lipids, vitamins, minerals and a gelling agent, and has an energy of 0.5 to 2.5 kcal / mL, and a preferred range of 1.0 to 1.6 kcal / mL. . The gel strength is 1 × 10 ² to 1 × 10 ⁵ N / m ² , and the preferred range is 5 × 10 ^{2 to} 5 × 10 ⁴ N / m ² , and it has a good throat when taken orally. Are preferred.

Examples of proteins include animal or plant proteins, hydrolysates of these proteins or amino acids. An appropriate amount of protein is 3 to 5 g per 100 kcal of the nutritional composition, so that sufficient protein can be ingested.
Examples of the carbohydrate include starch, dextrin, lactose, sucrose, glucose, fructose, maltose, powdered candy and the like. An appropriate amount of sugar is 10 to 18 g per 100 kcal of the nutritional composition, and an energy ratio of sugar is preferably 40 to 70%.
As lipids, vegetable oils such as soybean oil, rapeseed oil, corn oil, safflower oil, canola oil, coconut oil, sunflower oil, olive oil, perilla oil, sesame oil, animal oils such as beef tallow, lard, fish oil, MCT Oil and the like. The amount of fat is suitably 1 to 4.5 g per 100 kcal of the nutritional composition, and the energy ratio of fat is preferably 10 to 40%.
Examples of the mineral include sodium, calcium, potassium, magnesium, iron, phosphorus and the like, and it is preferable to mix these as much as possible. The following ranges are appropriate for the amount of the mineral to be added per 100 kcal of the nutritional composition.
Sodium 0-400mg, preferably 25-200mg
Calcium 0-2500mg, preferably 25-80mg
Iron 0 to 40 mg, preferably 0.5 to 1.5 mg
Phosphorus 0-4000mg, preferably 25-65mg
Magnesium 0-650mg, preferably 7-45mg
Potassium 0-2000mg, preferably 25-75mg
Copper 0-18mg, preferably 0.1-1mg
Manganese 0-8 mg, preferably 0.1-0.5 mg
Zinc 0-30mg, preferably 0.1-1.5mg

Examples of the gelling agent include gelatin, agar, pectin, carrageenan, guar gum, gellan gum, xanthan gum, tamarind gum, locust bean gum, sodium alginate and the like. It is preferable to use a mixture of several kinds having different characteristics. The amount of the gelling agent is suitably 0.2 to 1.0% by weight based on the total weight of the composition. The following range is appropriate per 100 kcal of the nutritional composition.
Gelatin 0.1-3%, preferably 0.5-2%
Agar 0.1-2.5%, preferably 0.5-2%
Pectin 0.1 to 4%, preferably gelling ability is increased by the presence of divalent cations, so that appropriate adjustment is required.
Carrageenan 0.1-2.5%, preferably gelation ability is increased by the presence of minerals, so that timely adjustment is required.
Xanthan-galactomannan (guar gum, gellan gum, xanthan gum, tamarind gum, locust bean gum, sodium alginate) 0.1 to 3%, and preferably 2% or less because it varies depending on the added food material, type, pH, and heating temperature.

Hereinafter, the nutritional composition of the present invention will be specifically described with reference to examples, but the present invention is not limited to only the following examples.
After dissolving in distilled water according to the composition described in Table 1, each 400 mL of the solution was filled into a 500 mL flexible container made of ethylene-vinyl acetate copolymer (trade name "Terpac" manufactured by Terumo Corporation), and sealed. Heat sterilization was performed at 121 ° C. for 10 minutes. After that, it was sealed in a gas barrier packaging material together with a deoxidizer until use. The viscosity of the nutritional composition of Example 1 was 16 mPa · s (25 ° C.) as measured with a viscometer (manufactured by Toki Sangyo: TV-30).

Comparative Example 1

After dissolving in distilled water in accordance with the composition described in Table 2, the solution was filled into a 500 mL flexible container made of ethylene-vinyl acetate copolymer (trade name "Terpac" manufactured by Terumo Corporation) in a capacity of 500 mL, sealed, and then sealed. Heat sterilization was performed at 121 ° C. for 10 minutes. After that, it was sealed in a gas barrier packaging material together with a deoxidizer until use. The viscosity of the nutritional composition of Comparative Example 1 was 15 mPa · s (25 ° C.) as measured with a viscometer (manufactured by Toki Sangyo: TV-30).

Comparative Example 2

After dissolving in distilled water in accordance with the composition described in Table 3, the solution was filled into flexible containers made of ethylene-vinyl acetate copolymer (trade name “Terpac” manufactured by Terumo Corporation) in a volume of 500 mL in a capacity of 500 mL, sealed, and then sealed. Heat sterilization was performed at 121 ° C. for 10 minutes. After that, it was sealed in a gas barrier packaging material together with a deoxidizer until use. The viscosity of the nutritional composition of Comparative Example 2 was 13 mPa · s (25 ° C.) as measured with a viscometer (manufactured by Toki Sangyo Co., Ltd., TV-30 type).

Test example 1

Using the nutritional compositions prepared in Example 1 and Comparative Examples 1 and 2, animal experiments on blood vitamin B1 concentration and blood glucose level were performed. Blood was collected from 6-week-old, SD male rats weighing 180 to 200 g after overnight fasting, and the blood vitamin B1 concentration and blood glucose level were measured (pre value). The number of examples was set to 5 in both Example 1 and Comparative Examples 1 and 2. 70% of the small intestine was excised except for 5 cm anally from the ligament of Treitz and 10 cm from the ileocecal portion of these rats to make a gastrointestinal surgery model, and a catheter was placed in the stomach. Each nutrient composition was continuously administered from a catheter at 270 kcal / kg / day for 7 days without restraint. After the administration, blood was collected from the inferior aorta to measure the blood vitamin B1 concentration and blood glucose level (post value).
The results of blood vitamin B1 concentration and blood glucose level are shown in FIGS. In the group to which the nutritional composition of Example 1 was administered, the blood vitamin B1 concentration increased to a post value of 387 ng / mL as compared to the pre value of 328 ng / mL, but the group to which the nutritional composition of Comparative Example 1 was administered was: The post value decreased to 238 ng / mL compared to the pre value of 337 ng / mL. In the group to which the nutritional composition of Comparative Example 2 was administered, the post value was reduced to 267 ng / mL, compared to the pre value of 341 ng / mL.
The blood glucose post value was 85.9 mg / dL in Example 1 and lower than 98.3 mg / dL in Comparative Example 1 or 96.3 mg / dL in Comparative Example 2.
Therefore, the nutritional composition of Example 1 in which the amount of vitamin B1 was increased maintained the blood vitamin B1 concentration at a high level even after gastrointestinal surgery in which the digestion and absorption of nutrients decreased, and further increased the blood glucose level. Nutrition was possible without any. On the other hand, in the nutritional composition of Comparative Example 1 or 2 in which the amount of vitamin B1 was low, a decrease in the blood vitamin B1 concentration was observed, and the blood sugar level tended to increase.

After dissolving in distilled water according to the composition described in Table 4, the solution was filled into a 500-mL flexible container made of ethylene-vinyl acetate copolymer (trade name "Terpac" manufactured by Terumo Corporation) in a capacity of 500 mL, and sealed. Heat sterilization was performed at 121 ° C. for 10 minutes. After that, it was sealed in a gas barrier packaging material together with a deoxidizer until use.

Comparative Example 3

After dissolving in distilled water in accordance with the composition described in Table 5, the solution was filled into a 500 mL flexible container made of ethylene-vinyl acetate copolymer (trade name "Terpac" manufactured by Terumo Corporation) in a capacity of 500 mL, and sealed. Heat sterilization was performed at 121 ° C. for 10 minutes. After that, it was sealed in a gas barrier packaging material together with a deoxidizer until use.

Comparative Example 4

After dissolving in distilled water in accordance with the composition described in Table 6, the solution was filled into 500 mL ethylene-vinyl acetate copolymer flexible containers (trade name "Terpac" manufactured by Terumo Corporation) in a volume of 500 mL, and sealed. Heat sterilization was performed at 121 ° C. for 10 minutes. After that, it was sealed in a gas barrier packaging material together with a deoxidizer until use. The viscosities of the nutritional compositions of Example 2, Comparative Examples 3 and 4 were 15, 11, and 18 mPa · s (25 ° C.), respectively, as measured with a viscometer (manufactured by Toki Sangyo Co., Ltd., TV-30 type). .

Test example 2

Using the nutritional compositions prepared in Example 2 and Comparative Examples 3 and 4, animal experiments on blood vitamin B1 concentration and blood glucose level were performed. Blood was collected from 10-week-old male SD rats weighing 390-430 g after fasting overnight, and the blood vitamin B1 concentration and blood glucose level were measured (pre value). The backs of these rats were shaved, and a III-degree burn was made on 20% of the body surface area using a soldering iron, and used as a burn model. Thereafter, the catheter was placed in the stomach. The nutritional composition of Example 2 or Comparative Examples 3 and 4 was continuously administered at 270 kcal / kg / day without restriction using a syringe pump from a catheter for 3 days. The number of cases was 5 in each of Example 2, Comparative Examples 3 and 4. From one day after the start of the administration to the end of the administration, the blood glucose level was measured every day. Three days after the start of the administration, the blood vitamin B1 concentration was measured.
The results of blood vitamin B1 concentration and blood glucose level are shown in FIGS. In the group to which the nutritional composition of Comparative Example 3 or 4 in which the amount of vitamin B1 was low was administered, the vitamin B1 concentration in blood was lower than the pre value 3 days after the start of administration. One day after the start of administration, the blood glucose level increased compared to the pre-level, and after 3 days, it was 159 mg / dL in Comparative Example 3 and 151 mg / dL in Comparative Example 4. On the other hand, in the group to which the nutritional composition of Example 2 having a high vitamin B1 content was administered, the blood vitamin B1 concentration 3 days after the start of administration showed a high value of 451 ng / mL as compared with Comparative Example 3 or 4, Further, the blood glucose level was lower than that of Comparative Example 3 or 4 throughout the administration period.
Therefore, the nutritional composition of Example 2 having a high vitamin B1 content maintains blood vitamin B1 at a high level even after a burn which is considered to cause hyperglycemia due to insulin resistance, and suppresses an increase in blood glucose level. I thought it could be done.

After dissolving in distilled water in accordance with the composition described in Table 7, the solution was filled into flexible containers made of ethylene-vinyl acetate copolymer (trade name “Terpac” manufactured by Terumo Corporation) in a capacity of 500 mL in a capacity of 500 mL, and sealed. Heat sterilization was performed at 121 ° C. for 10 minutes. After that, it was sealed in a gas barrier packaging material together with a deoxidizer until use.

Comparative Example 5

After dissolving in distilled water in accordance with the composition described in Table 8, the solution was filled into a flexible container made of ethylene-vinyl acetate copolymer (trade name "Terpac" manufactured by Terumo Corporation) in a volume of 500 mL in a capacity of 500 mL, and sealed. Heat sterilization was performed at 121 ° C. for 10 minutes. After that, it was sealed in a gas barrier packaging material together with a deoxidizer until use.

Comparative Example 6

After dissolving in distilled water according to the composition described in Table 9, the solution was filled into 500 mL ethylene-vinyl acetate copolymer flexible containers (trade name “Terpac” manufactured by Terumo Corporation) in a volume of 500 mL, and sealed. Heat sterilization was performed at 121 ° C. for 10 minutes. After that, it was sealed in a gas barrier packaging material together with a deoxidizer until use. The viscosities of the nutritional compositions of Example 3, Comparative Examples 5 and 6 were 14, 15, and 12 mPa · s (25 ° C.), respectively, as measured with a viscometer (manufactured by Toki Sangyo Co., Ltd., TV-30 type). .

Test example 3

Using the nutritional compositions prepared in Example 3 and Comparative Examples 5 and 6, animal experiments on blood vitamin B1 concentration and glucose tolerance were performed. A 7-month-old beagle dog weighing about 10 kg was fed with a restricted feed of a commercial solid feed of 5 g / kg / day for 14 days to reduce malnutrition. Thereafter, 200 kcal / head / day of the nutritional composition of Example 3 or Comparative Examples 5 and 6 was orally ingested for 14 days while continuing to limit the feed to 5 g / kg / day on the commercial solid feed. Blood vitamin B1 concentration was measured before and after restricted feeding and after administration of the nutritional composition. The number of examples was set to 5 in Example 3 and Comparative Examples 5 and 6. After the administration of the nutritional composition for 14 days, the animals were fasted all day and night, and a glucose tolerance test was performed by oral glucose load of 2 g / kg.
Table 10 shows the results of the blood vitamin B1 concentration. Blood vitamin B1 was reduced by restricted feeding, but in the group to which the nutritional composition of Example 3 was administered, the value was higher than the value before restricted feeding. On the other hand, in the groups to which the nutritional compositions of Comparative Examples 5 and 6 were administered, the blood vitamin B1 concentration was low.

FIG. 5 shows the results of a glucose tolerance test using an oral glucose load. In the group to which the nutritional composition of Example 3 was administered, the blood sugar level was always lower than in the groups to which the nutritional composition of Comparative Examples 5 and 6 was administered.
Therefore, even when the nutritional composition of Example 3 was ingested as a dietary supplement, it was considered that the blood vitamin B1 concentration could be maintained at a high level, and an increase in blood sugar level could be suppressed.

After dissolving in distilled water in accordance with the composition described in Table 11 and then directly steam sterilizing at 151 ° C. for 2 seconds, the solution was placed in polyethylene-paper-aluminum foil laminated paper containers (trade name “Tetrabrick (trade name)) in 125 mL volumes of 125 mL each. (Registered trademark) Aseptic "manufactured by Tetra Corporation. The viscosity of the nutritional composition of Example 4 was 11 mPa · s (25 ° C.) as measured with a viscometer (manufactured by Toki Sangyo: TV-30).

Test example 4

Using the nutritional composition prepared in Example 4, clinical evaluation was conducted on the blood vitamin B1 concentration and nutritional improvement. Nutrition improvement was evaluated for 10 elderly people (average 87.8 years old) who entered the geriatric health facility after drinking 1 bottle / day for 8 weeks. Blood vitamin B1 concentration, serum albumin concentration, and body weight before and after administration were measured.
The results of the blood vitamin B1 concentration are shown in FIG. In the late-elderly patients entering the geriatric health facility, the blood vitamin B1 concentration was lower than the lower reference limit (28 ng / ml) in 6/10 (60%), but 4 weeks of administration of the nutritional composition of Example 4. Later, all cases exceeded the reference lower limit. When the serum albumin value is 3.5 mg / dl or less, it is said that the patient is undernourished. The results of the serum albumin level are shown in FIG. Regarding 3/10 cases (30%) in which undernutrition was observed, administration of the nutritional composition of Example 4 caused an increase in serum albumin. The results of body weight are shown in FIG. An increase in body weight was observed by administration of the nutritional composition of Example 4.

After dissolving in distilled water according to the composition shown in Table 12, it is completely dissolved at 80 ° C. After filling the prepared solution in a 68 g capacity retort-resistant container, retort sterilization is performed. The gel strength of the nutritional composition of Example 5 was 1 × 10 ⁴ N / m ² (measurement instrument: Creepmeter-TPU-2S: manufactured by Yamaden Corporation), which was good when taken orally. Had a great throat.

FIG. 1 is a diagram showing blood vitamin B1 concentrations when the nutritional compositions of Example 1, Comparative Examples 1 and 2 were administered (Test Example 1). FIG. 2 is a diagram showing blood glucose levels when the nutritional compositions of Example 1, Comparative Example 1, and Comparative Example 2 were administered (Test Example 1). FIG. 3 is a graph showing blood vitamin B1 concentrations when the nutritional compositions of Example 2, Comparative Examples 3 and 4 were administered (Test Example 2). FIG. 4 is a graph showing blood glucose levels when the nutritional compositions of Example 2, Comparative Example 3, and Comparative Example 4 were administered (Test Example 2). FIG. 5 is a diagram showing the results of a glucose tolerance test when the nutritional compositions of Example 3, Comparative Examples 5 and 6 were administered (Test Example 3). FIG. 6 is a graph showing the results of blood vitamin B1 concentration when the nutritional composition of Example 4 was administered (Test Example 4). FIG. 7 is a diagram showing the results of changes in body weight when the nutritional composition of Example 4 was administered (Test Example 4). FIG. 8 is a diagram showing the results of serum albumin concentration when the nutritional composition of Example 4 was administered (Test Example 4).

Claims (2)

A nutritional composition containing proteins, carbohydrates and lipids as main components, and vitamins and minerals, wherein the nutritional composition contains 4 mg or more of vitamin B1 per 100 kcal of the nutritional composition. The nutritional composition according to claim 1, wherein the vitamin B1 content is 11 mg or less per 100 kcal of the nutritional composition.

Images