JP2004077204A - Fluid passage test apparatus and fluid passage test method - Google Patents

Abstract

An object of the present invention is to provide a fluid passage test apparatus and a fluid passage test method capable of efficiently performing a fluid passage test on a large number of samples.
A liquid passage test device (1) has a sample storage section (3) for storing a sample (9) to be subjected to a test. The sample storage section 3 has a first holding section 31 having a first flow path 60 and a second flow path 70, and holds a sample 9 between the first holding section 31 and the first holding section 31. The liquid 8 is supplied to the sample 9 through the first channel 60 in a state where the sample 9 is held by the first holding unit 31 and the second holding unit 32. The liquid 8 that has flowed out through the sample 9 is recovered through the second channel 70. Further, the sample storage unit 3 has a holding force increasing unit 33 that increases the holding force of the sample 9 by bringing the first holding unit 31 and the second holding unit 32 closer to each other.
[Selection diagram] FIG.

Description

【０１２５】
表１から明らかなように、サンプルの通液量が、焼結体の空孔率の増加に伴って、多くなることが確認された。
【０１２６】
また、本実施例で作製した液体の通過試験装置では、サンプルの取替えが極めて簡単であり、サンプルの交換を短時間に行うことができた。
【０１２７】
【発明の効果】
以上述べたように、本発明によれば、人体に有害な有機溶剤を用いることなく、しかも、短時間で被検物の交換を行うことができる。
【０１２８】
よって、多数の被検物について効率よく流体の通過試験を実施することが可能である。
【０１２９】
また、各被検物間で試験条件を一定に設定することが容易であるため、試験結果にバラツキが生じることも少なく、正確な試験結果を得ることもできる。
【図面の簡単な説明】
【図１】本発明の流体の通過試験装置の実施形態を示す模式図である。
【図２】図１に示す流体の通過試験装置が備えるサンプル収納部付近の縦断面図である。
【図３】本発明の流体の通過試験に供されるサンプルを示す斜視図である。
【符号の説明】
１　　　　　　液体の通過試験装置
２　　　　　　液体貯留容器
２１　　　　　底部
２２　　　　　液体排出口
２３　　　　　フィルター
３　　　　　　サンプル収納部
３１　　　　　第１の保持部
３１１　　　　接触部材
３１２　　　　外側部材
３１３　　　　凹部
３２　　　　　第２の保持部
３２１　　　　接触部材
３２２　　　　外側部材
３２３　　　　凹部
３３　　　　　保持力増大手段
３４　　　　　第１の接合部材
３４１　　　　ネジ溝
３５　　　　　第２の接合部材
３５１　　　　ネジ山
４　　　　　　液体回収容器
４１　　　　　上部開口
４２　　　　　栓
４２１　　　　流路管用孔
４２２　　　　接続管用孔
５　　　　　　真空ポンプ
６　　　　　　第１の流路管
６０　　　　　第１の流路
７　　　　　　第２の流路管
７０　　　　　第２の流路
８　　　　　　液体
９　　　　　　サンプル
９０　　　　　被膜
９０１　　　　流入口
９０２　　　　流出口
１０　　　　　接続管
１１　　　　　三方活栓
１１１　　　　接続口
１２　　　　　接続管
１３　　　　　真空計
１４　　　　　バルブ
１５　　　　　バルブ[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a fluid passage test apparatus and a fluid passage test method.
[0002]
[Prior art]
Hydroxyapatite is a main component of bone and teeth, has excellent biocompatibility, and is used as a biomaterial such as artificial bone, artificial root, medical or dental cement.
[0003]
A sintered body of hydroxyapatite (hereinafter, simply referred to as a “sintered body”) is used as the artificial bone or the artificial tooth root. In this case, such a sintered body is required to have sufficient mechanical strength and biocompatibility.
The mechanical strength and biocompatibility greatly depend on the porosity of the sintered body.
[0004]
That is, if the porosity of the sintered body is too small, the mechanical strength is increased, but the biocompatibility is deteriorated because penetration of proteins and the like into the sintered body becomes difficult. Higher porosity results in better biocompatibility but lower mechanical strength.
[0005]
Therefore, in order to obtain an optimal sintered body as a target biomaterial, it is important to select an index for grasping the porosity of the sintered body.
[0006]
Here, as an index of the porosity of the sintered body, for example, a liquid passing rate (liquid passing speed) per unit time when a liquid is passed through the sintered body is exemplified. The measurement of the flow rate of the sintered body has been conventionally performed as follows.
{Circle around (1)} First, a sintered body formed in a disk shape is prepared as a sample.
{Circle around (2)} Next, the edge of the sample is fixed to the inner peripheral surface of the funnel-shaped installation portion with a resin (adhesive).
(3): Next, in the state of (2), the liquid is supplied to the upper surface side of the sample.
{Circle around (4)}: Then, the amount of liquid flowing out through the sample is measured.
[0007]
By dividing the amount of the obtained liquid by the time required for the outflow, the flow rate (flow rate) of the sample (sintered body) per unit time is obtained.
[0008]
However, in such a method, the sample is fixed to the installation portion with a resin, so when measuring the next sample, the resin must be dissolved and removed with an organic solvent or the like, and the sample must be removed from the installation portion. Must.
[0009]
This resin dissolution usually requires two to three days, and there is a problem in that the flow rate cannot be measured efficiently for a large number of samples. Further, there is also a problem that an organic solvent (for example, trichloroethylene or the like) used for dissolving the resin is harmful to a human body.
[0010]
[Problems to be solved by the invention]
An object of the present invention is to provide a fluid passage test device and a fluid passage test method that can efficiently perform a fluid passage test on a large number of samples.
[0011]
[Means for Solving the Problems]
Such an object is achieved by the present invention described in the following (1) to (18).
[0012]
(1) a first holding unit;
A second holding unit for holding a liquid-permeable or gas-permeable test object between the first holding unit and the first holding unit;
A first flow path provided on the first holding unit side;
A second flow path provided on the second holding portion side,
In a state where the test object is held by the first holding unit and the second holding unit, a fluid is supplied to the test object via the first flow path and passes through the test object. A fluid passing test apparatus configured to collect the fluid that has flowed out through the second flow path.
[0013]
ADVANTAGE OF THE INVENTION According to this invention, without using an organic solvent harmful to a human body, moreover, a test object can be exchanged in a short time, and therefore, a fluid passage test can be efficiently performed on a large number of test objects. It is possible.
[0014]
(2) a first holding unit having a first flow path;
A second holding portion that holds the test object between the first holding portion and the second holding portion;
In a state where the test object is held by the first holding unit and the second holding unit, a fluid is supplied to the test object via the first flow path and passes through the test object. A fluid passing test apparatus configured to collect the fluid that has flowed out through the second flow path.
[0015]
ADVANTAGE OF THE INVENTION According to this invention, without using an organic solvent harmful to a human body, moreover, a test object can be exchanged in a short time, and therefore, a fluid passage test can be efficiently performed on a large number of test objects. It is possible.
[0016]
(3) Holding force increasing means for bringing the first holding unit and the second holding unit close to each other and increasing the holding force of the test object by the first holding unit and the second holding unit. The fluid passage test device according to the above (1) or (2), comprising:
Thereby, the test object can be held more reliably.
[0017]
(4) a first joining member provided outside the first holding unit and rotatable around the first flow path as a rotation center;
Any of the above (1) to (3), which can be connected to the first joint by screwing, and is constituted by a second joint member provided outside the second holding portion. The fluid passage test apparatus according to the above.
[0018]
Thereby, the operation of increasing the holding force of the test object by the first holding unit and the second holding unit can be more easily performed.
[0019]
(5) In the state where the test object is held on the outer surface thereof by the first holding portion and the second holding portion, at least the first flow path and the second The fluid passage test apparatus according to any one of the above (1) to (4), wherein the fluid passage test apparatus has a coating having a fluid blocking property formed except for a portion facing the flow path.
Thus, it is possible to prevent the fluid from leaking around the test object.
[0020]
(6) The first holding unit and the second holding unit are configured to hold the test object by the first holding unit and the second holding unit, respectively. Having a contact member to contact, an outer member provided outside the contact member,
The fluid passage test device according to any one of (1) to (5), wherein the contact member is made of a material that is more flexible than the outer member.
[0021]
Accordingly, in a state in which the test object is held by the first holding unit and the second holding unit, high liquid tightness and high liquid tightness are provided between the first holding unit and the second holding unit and the test object. Airtightness is ensured.
[0022]
(7) The liquid supply device according to any one of (1) to (6), further including a space that communicates with the second flow path, and a fluid collection container that collects the fluid that has flowed out of the test object. Fluid passage test equipment.
Thereby, the flow rate of the fluid that has passed through the test object can be quantified.
[0023]
(8) The above (1) to ((1) to (1) to (4), further comprising a decompression unit for depressurizing the inside of the fluid passage test apparatus in a state where the test object is held by the first holding unit and the second holding unit. The fluid passage test apparatus according to any one of 7) to 7).
[0024]
Thus, the fluid can be forcibly supplied to the test object, and as a result, the fluid passage test can be smoothly performed.
[0025]
(9) Decompression means for depressurizing the inside of the fluid passage test device in a state where the test object is held by the first holding portion and the second holding portion,
The fluid passage test according to (7), wherein the pressure reducing unit is provided downstream of the fluid recovery container, and reduces the pressure in the fluid recovery container to reduce the pressure in the fluid passage test apparatus. apparatus.
[0026]
This makes it possible to easily and accurately bring the inside of the fluid passage test apparatus into a reduced pressure state without separately adding an operation for preventing the flow of the fluid into the pressure reducing means.
[0027]
(10) The fluid passage test device according to the above (8) or (9), further comprising a pressure adjusting unit capable of adjusting a pressure in the fluid passage test device when the pressure is reduced.
[0028]
Thus, the flow rate of the fluid can be easily changed according to the characteristics of the test object.
[0029]
(11) The above (1) to (10), which is connected to the middle of the first flow path or the middle of the second flow path and has a pressure detecting means for detecting a pressure in the fluid passage test apparatus. The fluid passage test device according to any one of the above.
[0030]
Thereby, the pressure in the fluid passage test device can be grasped more accurately.
[0031]
(12) The fluid passage test device according to any one of (1) to (11), further including a space that communicates with the first flow path, and including a fluid storage container that stores the fluid.
This reduces restrictions on the installation location of the device and facilitates movement of the device.
[0032]
(13) The fluid passage test device according to (12), wherein the fluid storage container has a filter that removes foreign matter from the fluid.
Thus, it is possible to prevent the test object from being clogged with foreign matter.
[0033]
(14) The fluid passage test apparatus according to any one of (1) to (13) above, wherein the characteristics of the test object can be known by checking the liquid permeability or the gas permeability of the test object.
According to the present invention, a test object can be evaluated by a simple method.
[0034]
(15) The fluid passage test apparatus according to any one of (1) to (14), wherein the fluid is a liquid.
Liquids are easy to handle.
[0035]
(16) A method for testing the passage of a fluid, which is performed using the apparatus for testing the passage of a fluid according to any one of the above (1) to (15).
[0036]
According to the present invention, it is easy to set the test conditions to be constant among the respective test objects, so that there is little variation in the test results, and accurate test results can be obtained.
[0037]
(17) The liquid-permeable or gas-permeable specimen is held by being sandwiched from both sides by a pair of flow pipes, and a fluid is supplied to the specimen from one of the flow pipes. A fluid passing test method comprising recovering fluid flowing out of the other flow pipe through the fluid passage.
[0038]
According to the present invention, it is easy to set the test conditions to be constant among the respective test objects, so that there is little variation in the test results, and accurate test results can be obtained.
[0039]
(18) The test objects having different conditions are exchanged, and the liquid permeability or the air permeability of each of the test objects is examined. The difference in the liquid permeability or the air permeability between the test objects is determined. The method for testing the passage of a fluid according to the above (16) or (17), wherein the relative relationship between the conditions between the test objects can be known.
According to the present invention, a test object can be evaluated by a simple method.
[0040]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, preferred embodiments of the fluid passage test apparatus and the fluid passage test method of the present invention will be described in detail.
[0041]
FIG. 1 is a schematic diagram showing an embodiment of the fluid passage test apparatus of the present invention, FIG. 2 is a longitudinal sectional view showing the vicinity of a sample storage portion provided in the fluid passage test apparatus shown in FIG. 1, and FIG. FIG. 4 is a perspective view showing a sample subjected to a fluid passage test. In the following description, the upper side in FIG. 1 is referred to as “upper” or “upper”, and the lower side is referred to as “lower” or “lower”. 2 is referred to as “upstream” and the right side as “downstream”.
[0042]
The fluid passage test device of the present invention is a device that supplies a sample (test object) with a fluid and collects the fluid that has flowed out of the sample. Liquid permeability or gas permeability). By examining the liquid permeability or air permeability, for example, when a plurality of samples have the same porosity but have lower liquid permeability or gas permeability than other samples, Indicates that the sample has some defect. That is, defective products can be easily and reliably found. In addition, as the defect, for example, when the sample is manufactured by sintering a compact obtained by compacting the raw material powder or the like, due to a variation in the particle size distribution of the raw material powder, It is conceivable that the communication hole formed by the gap between the bodies is closed. For example, when the product is a biomaterial, a decrease in liquid permeability or air permeability due to blockage of the communication hole is not desirable because it is likely to affect fusion with bone.
[0043]
Here, in the present invention, any of a liquid and a gas may be used as the fluid, but it is preferable to use a liquid because handling is easy. Hereinafter, a case where a liquid is used as a fluid will be described as a representative.
[0044]
A liquid passage test apparatus 1 (hereinafter, simply referred to as “apparatus 1”) shown in FIG. 1 includes a liquid storage container 2, a sample storage unit 3, a liquid recovery container 4, a vacuum pump (decompression means) 5, have.
[0045]
The liquid storage container 2 and the sample storage unit 3 are connected (connected) by a first flow path pipe (one flow path pipe) 6, and the sample storage unit 3 and the liquid recovery container 4 are connected to each other by a second flow path pipe. The liquid recovery container 4 and the vacuum pump 5 are connected (connected) by a connection pipe 10.
[0046]
The liquid storage container 2 is a container for storing the liquid 8. The liquid storage container 2 has a bottomed cylindrical shape, and has a conical shape (a funnel) with an inner diameter gradually increasing upward near the upper opening.
[0047]
A liquid outlet 22 is provided at the bottom 21 of the liquid storage container 2, and the liquid 8 stored in the liquid storage container 2 is discharged from the liquid outlet 22.
[0048]
A filter 23 is provided inside the liquid storage container 2 in the vertical direction. When passing through the filter 23, foreign substances such as dust and dust mixed in the liquid 8 are removed. Accordingly, it is possible to prevent foreign matter from clogging the holes (holes, small-diameter flow paths, and the like) of the sample 9.
[0049]
The opening diameter of the filter 23 is not particularly limited, but is preferably about 1 to 3 μm, and more preferably about 0.2 to 10 μm. If the opening diameter of the filter 23 is too small, depending on the type of the liquid 8, the passage (filtration) speed becomes extremely slow or the filter 23 is clogged. As a result, the passage test of the liquid 8 (hereinafter simply referred to as “ Test ”). If the opening diameter of the filter 23 is too large, there is a possibility that foreign substances mixed in the liquid 8 cannot be sufficiently removed.
[0050]
The liquid recovery container 4 is a container for collecting the liquid 8 that has passed through the sample 9 and flowed out. The liquid recovery container 4 has a bottomed cylindrical shape, and its upper opening 41 is hermetically sealed by a stopper 42 such as a rubber stopper.
[0051]
The plug 42 has a passage pipe hole 421 through which the second passage pipe 7 is inserted, and a connection pipe hole 422 through which the connection pipe 10 connected to the vacuum pump 5 is inserted. The second flow path pipe 7 and the connection pipe 10 are connected to each other such that the end of the second flow path pipe 7 is located below the end of the connection pipe 10 in the liquid recovery container 4. The holes are inserted into the holes 421 and 422, respectively.
[0052]
The vacuum pump 5 is connected to the liquid recovery container 4 via a connection pipe 10. The vacuum pump 5 holds the liquid collection container 4 in a state where the sample 9 is stored in the sample storage unit 3 (a state where the sample 9 is held by the first holding unit 31 and the second holding unit 32) as described later. By reducing the pressure inside, the inside of the apparatus 1 can be brought into a reduced pressure state. Thereby, the liquid 8 can be forcibly supplied to the sample 9, and as a result, the test can be performed smoothly.
[0053]
Further, the vacuum pump 5 may be directly connected to the second flow path pipe 7. However, by configuring the inside of the apparatus 1 to be in a reduced pressure state through the liquid recovery container 4, An operation for preventing the liquid 8 from flowing into the vacuum pump 5 (for example, an operation for switching the second flow path 70, etc.) can be easily and accurately brought into a decompressed state without separately adding an additional operation. it can. Further, since such an operation is not required, there is an advantage that the inside of the apparatus 1 can be continuously kept under reduced pressure.
[0054]
A valve 14 is provided in the middle of the connection pipe 10, and the pressure in the device 1 can be adjusted by adjusting the opening of the valve 14. The valve 14 constitutes a pressure adjusting means capable of adjusting the pressure in the apparatus 1 during pressure reduction. By providing such a valve (pressure adjusting means) 14, the flow rate of the liquid 8 can be easily changed in accordance with the characteristics of the sample 9.
[0055]
One end of the first flow path tube 6 is connected to the liquid outlet 22 of the liquid storage container 2, and the other end is connected to the sample storage unit 3 (first holding unit 31). Thereby, the first flow path 60 is formed continuously in the first holding portion 31 and the first flow path pipe 6, and the first flow path 60 is formed in the internal space of the liquid storage container 2. Is in communication with
[0056]
The second flow path pipe 7 has one end inserted into the flow path pipe hole 421 of the plug 42 and the other end connected to the sample storage section 3 (second holding section 32). As a result, a second flow path 70 is continuously formed in the second holding portion 32 and the second flow path pipe 7, and the second flow path 70 is formed in the internal space of the liquid recovery container 4. Is in communication with
[0057]
The diameters of the first flow path 60 and the second flow path 70 (the inner diameters of the first flow path pipe 6 and the second flow path pipe 7) are not particularly limited. Is preferably about 0.5 to 2.0, and more preferably about 0.7 to 1.5. The inner diameter of the second flow path pipe 7 is preferably about 0.8 to 2.0 times the inner diameter of the first flow path pipe 6, and more preferably about 1.0 to 1.5 times. preferable. If the inner diameter of each of the flow pipes 6 and 7 is too large, the volume of the entire flow pipe becomes too large, and it may take a long time to start the test. If (in particular, the inner diameter of the first flow path pipe 6) is too small, depending on the viscosity of the liquid 8, the size of the pore diameter (pore diameter) of the sample 9, etc., the liquid 8 in the flow path pipes other than the sample 9 may be used. In some cases, the passing resistance (load) increases, the reliability of the measurement result (test result) is reduced, or the measurement result needs to be corrected. The same applies to the case where the sample 9 has a coating 90 as described later. That is, the inlet of the liquid 8 to the sample 9 corresponds to the opening in the first holding portion 31 of the first flow channel 60 when the sample 9 does not have the coating 90, while the sample 9 In the case of having the opening 90, the opening 90 in the first holding portion 31 of the first flow path 60 or the inlet 901 of the coating 90 has a smaller diameter.
[0058]
Further, the first flow path pipe 6 and the second flow path pipe 7 are preferably substantially transparent (colorless transparent, colored transparent or translucent), respectively, in order to ensure the visibility inside. I have.
[0059]
A three-way cock (channel switching means) 11 is provided in the middle of the second channel tube 7 (second channel 70). A vacuum gauge (pressure detecting means) 13 is connected via a connection pipe 12 to a connection port 111 of the three-way cock 11 which is orthogonal to the second flow path pipe 7.
[0060]
The vacuum gauge 13 measures (detects) the pressure in the apparatus 1, and for example, a Bourdon tube vacuum gauge or the like is used. By providing the vacuum gauge 13, the pressure in the apparatus 1 can be grasped more accurately.
[0061]
The vacuum gauge 13 may be connected in the middle of the first flow path pipe 6 instead of the second flow path pipe 7.
[0062]
Further, a valve 15 is provided in the middle of the connection pipe 12, and by closing this valve 15, it is possible to prevent the liquid 8 from flowing back to the vacuum gauge 13 when the vacuum pump 5 is stopped. it can.
[0063]
As shown in FIG. 2, the sample storage unit 3 includes a first holding unit 31 on the upstream side and a second holding unit 32 on the downstream side. The sample 9 is held between the sample and the second holding unit 32.
[0064]
As described above, the first flow path pipes 6 are connected to the first holding unit 31, and the first flow paths 60 are continuously formed inside these. The second flow path pipes 7 are connected to the second holding portion 32, and a second flow path 70 is continuously formed inside these.
[0065]
The first holding unit 31 is provided with a contact member 311 that comes into contact with the sample 9 in a state where the sample 9 is held by the first holding unit 31 and the second holding unit 32, and provided outside the contact member 311. Outside member 312.
[0066]
The first channel pipe 6 is connected to the outer member 312. In the present embodiment, the outer member 312 and the first flow path pipe 6 are formed integrally.
[0067]
The outer member 312 has a substantially mortar shape, and a substantially conical contact member 311 is fixed (fixed) inside thereof.
[0068]
A concave portion 313 corresponding to the shape of the sample 9 is formed on the end surface of the contact member 311 on the sample 9 side, and the first flow channel 60 is opened in the concave portion 313.
[0069]
For the contact member 311 and a contact member 321 described later, it is preferable to use a material that is more flexible than the materials of the outer members 312 and 322 (the first flow path pipe 6 and the second flow path pipe 7), respectively. Examples thereof include silicone rubber, polyurethane, natural rubber, polyvinyl chloride and the like. This makes it possible to improve the adhesion of the first holding unit 31 and the second holding unit 32 to the sample 9 in a state where the sample 9 is held by the first holding unit 31 and the second holding unit 32. it can.
[0070]
The second holding unit 32 also has the same configuration as the first holding unit 31. The second holding unit 32 has a contact member 321 and an outer member 322, and the contact member 321 on the sample 9 side. A concave portion 323 is formed on the end surface of the hologram.
[0071]
The sample 9 is held (fixed) by the first holding portion 31 and the second holding portion 32 by fitting both ends of the sample 9 into the concave portions 313 and 323, respectively.
[0072]
Furthermore, in the present embodiment, the first holding unit 31 and the second holding unit 32 are brought closer to each other, and the holding force for increasing the holding force of the sample 9 by the first holding unit 31 and the second holding unit 32 is increased. The sample holding section 3 is configured by the holding force increasing section 33, the first holding section 31, and the second holding section 32.
[0073]
The holding force increasing means 33 includes a first joining member 34 provided outside the first holding portion 31 and a second joining member 35 provided outside the second holding portion 32. I have.
[0074]
The first joining member 34 has a substantially cylindrical shape. The shape of the lumen of the first joining member 34 corresponds to the external shape of the first holding portion 31 and the first flow path tube 6. The downstream ends of the first holding portion 31 and the first flow path tube 6 are located in the lumen of the first joining member 34.
[0075]
The first joining member 34 is configured as a member separate from the first holding portion 31 and the first flow path pipe 6, and is rotatable around the first flow path pipe 6 as a rotation center.
[0076]
Further, a thread groove 341 is formed on the downstream outer surface of the first joining member 34.
[0077]
On the other hand, the second joining member 35 also has a substantially cylindrical shape. On the downstream side of the second joining member 35, a reduced diameter portion whose inner diameter is reduced is formed, and in this reduced diameter portion, the second joining member 35 is fixed to the second flow path pipe 7 ( Fixed).
[0078]
Further, a thread 351 that is screwed with the thread groove 341 is formed on the inner surface on the upstream side of the second joining member 35.
[0079]
In such a sample storage unit 3, the sample 9 is held (fixed) by the first holding unit 31 and the second holding unit 32, and the first joint member 34 and the second joint member 35 are manually held. To rotate the first joint member 34 with respect to the second joint member 35. Thereby, the screw groove 341 and the screw thread 351 are screwed together, and the first joint member 34 and the second joint member 35 are connected. Further, when the first joint member 34 is rotated with respect to the second joint member 35, the first joint member 34 approaches the second joint member 35. At this time, the first holding member 31 is pressed by the first joining member 34, approaches the second holding member 32, and the sample 9 is tightened from both sides, so that the first holding member 31 and the first holding member 31 It is held (fixed) in a state where the holding force by the second holding portion 32 is increased. Thereby, the sample 9 can be held more reliably. In particular, since the first joining member 34 and the second joining member 35 are configured to be connected by screwing, the above operation can be performed more easily.
[0080]
At this time, since both the contact member 311 and the contact member 321 are made of a flexible resin material, there is no gap between them and both ends of the sample 9, and high liquid tightness is obtained. And airtightness are ensured.
[0081]
The first joining member 34 and the second joining member 35 need only be fixed in a state of approaching each other, and are not limited to those connected by screwing.
[0082]
Here, as a constituent material of the outer members 312, 322, the first flow path pipe 6, the second flow path pipe 7, the first connection member 34, and the second connection member 35, relatively high hardness is used, respectively. It is preferable to use a material such as, for example, polyethylene, polypropylene, polybutadiene, polyolefin such as ethylene-vinyl acetate copolymer, polyvinyl chloride, polyurethane, polystyrene, polymethyl methacrylate, polycarbonate, polyamide, polyethylene Examples include polyesters such as terephthalate and polybutylene terephthalate, acrylic resins, ABS resins, AS resins, ionomers, various resin materials such as polyacetal, polyphenylene sulfide, and polyetheretherketone, various metal materials, and various ceramic materials. By using such a material, when the inside of the apparatus 1 is in a decompressed state, it is possible to preferably prevent deformation, breakage, and the like of each of the above members.
[0083]
Using the device 1 as described above, a test of the sample 9 is performed as follows. Hereinafter, the fluid passage test method of the present invention will be described.
[0084]
First, a sample 9 to be tested is prepared.
The sample 9 may be any sample through which a fluid (liquid or gas) can pass, that is, any sample having a hole such as a hole or a small-diameter channel. Apatite (calcium phosphate compound), oxide ceramics such as alumina, silica, titania, zirconia, and yttria; nitride ceramics such as silicon nitride, aluminum nitride, titanium nitride, and boron nitride; graphite, tungsten carbide Of various ceramics such as various carbide-based ceramics, ferroelectric materials such as barium titanate, strontium titanate, PZT, PLZT, PLLZT, minerals such as zeolite, polyethylene, polypropylene, polybutadiene, and ethylene-vinyl acetate Polyolefins such as polymers, Polyester (vinyl chloride, polyurethane, polystyrene, polymethyl methacrylate, polycarbonate, polyamide, polyethylene terephthalate, polyester such as polybutylene terephthalate, acrylic resin, ABS resin, AS resin, ionomer, polyacetal, etc.) ) And the like.
[0085]
The shape of the sample 9 is not particularly limited, but is preferably a cubic shape, a rectangular parallelepiped shape, or the like, for example, because storage and handling are easy.
[0086]
In this case, the size (dimension) of the sample 9 is, for example, about 6 to 10 mm in length, 6 to 10 mm in width, and about 6 to 10 mm in height.
[0087]
Next, as shown in FIG. 3, when the sample 9 is stored (installed) in the sample storage unit 3, a portion facing the first flow path 60 and the second flow path 70 is left on the outer surface of the sample 9. Thus, a coating 90 having a liquid blocking property (fluid blocking property) is formed. Note that, of the portions where the coating 90 is not formed, the portion on the first flow channel 60 side is referred to as “inflow port 901”, and the portion on the second flow channel 70 side is referred to as “outflow port 902”. The provision of the coating 90 can prevent the liquid 8 passing through the sample 9 from leaking around the sample 9. Furthermore, as will be described later, when the inside of the apparatus 1 is depressurized, it is preferable to prevent the inconvenience that the depressurization effect is reduced due to air leaking from portions other than the portions facing the respective flow paths 60 and 70 in the sample 9. Can be. The formation of the coating 90 is particularly effective when the sample 9 is entirely porous.
[0088]
The coating 90 is preferably mainly composed of a resin material, and specific examples thereof include, for example, epoxy resin, polymethyl methacrylate, and polyvinyl chloride, and one or more of these are used. They can be used in combination.
[0089]
Further, the average thickness of the coating 90 is not particularly limited, but is preferably 0.5 mm or more, and more preferably 1.0 mm or more.
[0090]
Then, such a sample 9 is stored (installed) in the sample storage unit 3. That is, as described above, both ends of the sample 9 are fitted into the concave portions 313 of the first holding portion 31 (contact member 311) and the concave portions 323 of the second holding portion 32 (contact member 321), respectively. Then, the first joint member 34 and the second joint member 35 are respectively gripped by hand, and the first joint member 34 is rotated with respect to the second joint member 35, whereby the screw groove 341 and the screw are formed. The first joint member 34 and the second joint member 35 are connected by screwing the ridge 351 together. Furthermore, when the first joining member 34 is rotated with respect to the second joining member 35, the first holding portion 31 and the second holding portion 32 gradually approach, and the sample 9 is strongly Be tightened.
[0091]
In this way, the liquid 8 is supplied to the sample 9 while the sample 9 is stored (installed) in the sample storage unit 3.
[0092]
First, the three connection ports of the three-way cock 11 shown in FIG. 1, the valve 14 and the valve 15 are all opened.
[0093]
Next, the liquid 8 is injected from the upper opening of the liquid storage container 2. The liquid 8 passes through the filter 23 to remove foreign substances, and is stored in the liquid storage container 2.
[0094]
The liquid 8 to be used is preferably selected from those which do not react with the sample 9 or dissolve the sample 9 in consideration of the viscosity and the like. Examples of such liquid 8 include distilled water, ion-exchanged water, RO water, methanol, ethanol, benzene, phosphoric acid solution, physiological saline, simulated body fluid, and the like. Sample 9 is a hydroxyapatite sintered body. In that case, distilled water is preferred.
[0095]
Next, the vacuum pump 5 is operated, and the inside of the apparatus 1 is depressurized. As a result, the liquid 8 stored in the liquid storage container 2 is sucked (guided) into the flow channel system in the device 1, passes through the first flow channel 60 and the sample 9 sequentially, and passes through the second flow channel. Outflow to 70.
[0096]
Then, when the liquid 8 flows into the second flow path 70, the opening of the valve 14 is adjusted to adjust the pressure measured by the vacuum gauge 13 to a predetermined pressure. The predetermined pressure is not particularly limited, but is preferably about -102 to -50 kPa, and more preferably about -70 to -30 kPa.
[0097]
Next, the connection port 111 of the three-way cock 11 to which the vacuum gauge 13 is connected is closed. Thereafter, the liquid 8 passes through the second flow path 70, flows into the liquid recovery container 4, and is recovered.
[0098]
The amount of the liquid 8 collected in the liquid collecting container 4 is measured and divided by the time required for the outflow (collection) to obtain the amount of the sample 9 passed per unit time. Thereby, the liquid permeability of the sample 9 can be examined.
[0099]
By examining the liquid permeability of the sample 9, the characteristics of the sample 9 can be known. This feature includes, for example, the presence or absence of a communication hole, the degree of communication, and the like.
[0100]
In order to obtain a more accurate test result, it is preferable to temporarily fill the inside of the device 1 with the liquid 8 before starting the test. In this case, when the operation of the vacuum pump 5 is started and the liquid 8 starts to flow into the liquid recovery container 4, the operation of the vacuum pump 5 is temporarily stopped, the liquid recovery container 4 is removed, and another liquid is removed. After replacing the collection container 4, the vacuum pump 5 is operated again.
[0101]
In addition, by using a graduated container as the liquid recovery container 4, the amount of the recovered liquid 8 can be measured without removing the liquid recovery container 4 from the apparatus 1, which is convenient. Of course, in the case of the liquid 8 whose specific gravity is known, the amount can be determined from the weight.
[0102]
As described above, the test on one sample 9 is completed, but in the device 1, when the next sample 9 is present, the connection between the first connection member 34 and the second connection member 35 is released. Then, the sample 9 is removed from the sample storage unit 3. Then, the next sample 9 is stored (installed) in the sample storage unit 3 in the same manner as described above.
[0103]
As described above, according to the present invention, the sample 9 can be held (fixed) by the first holding unit 31 and the second holding unit 32 instead of directly fixing the sample 9 to the device 1 with the resin (adhesive). Thus, when exchanging the sample 9, it is not necessary to remove the resin (adhesive). Therefore, the sample 9 can be replaced in a short time without using an organic solvent harmful to the human body. Therefore, a test can be efficiently performed on many samples 9. Further, since it is easy to set the test conditions constant between the samples 9, there is little variation in the test results, and accurate test results can be obtained.
[0104]
Further, the samples 9 having different conditions (characteristics) are sequentially exchanged, and the liquid permeability of each sample 9 is examined. Based on the difference (large or small) in the liquid permeability between the samples 9, the porosity (porosity) is determined. It is possible to know the difference in the communication between the samples 9 having substantially the same values, the correlation with the pore diameter (pore diameter), and the like. As described above, according to the present invention, the sample 9 can be evaluated by a simple method.
[0105]
As described above, the liquid passage test apparatus and the liquid passage test method of the present invention have been described. However, the present invention is not limited to this, and each unit constituting the liquid passage test apparatus exhibits the same function. It can be replaced with any configuration. Also, an arbitrary configuration may be added.
[0106]
When a gas is used as the fluid, for example, an inert gas such as carbon dioxide, nitrogen, oxygen, argon gas, and helium gas can be used as the gas.
[0107]
Also, for example, a valve can be added for any purpose in the middle of each flow path.
[0108]
【Example】
Next, specific examples of the present invention will be described.
1. Fabrication of liquid test equipment
The liquid passage test device shown in FIGS. 1 to 3 was manufactured. The specifications of each part are as follows.
・ Liquid storage container
Constitution material: Glass
Capacity: 100mL
・ Filter (filter paper)
Opening diameter: 1 μm
・ Vacuum gauge: Bourdon tube vacuum gauge
・ Liquid recovery container
Constitution material: glass
Capacity: 100mL
・ First flow path pipe and second flow path pipe
Constitution material: Polypropylene
Inner diameter: 6mm
・ Sample storage
.First and second holding units
・ Outer member
Constitution material: Polypropylene
・ Contact member
Constitution material: Silicone rubber
.First connection member and second connection member
Constitution material: Polystyrene
[0109]
2. Preparation of sample
(Sample 1)
A hydroxyapatite sintered body having a porosity of 34.8% (dimensions: length 8 mm × width 8 mm × height 8 mm) was prepared.
[0110]
Then, on the outer surface of the hydroxyapatite sintered body, a film made of an epoxy resin (manufactured by Ciba Ltd., “Araldite”) was formed, and a sample as shown in FIG. 3 was obtained. The portion where the coating was not formed had a circular shape with a diameter of 5 mm, and the average thickness of the coating was 1.4 mm.
[0111]
(Sample 2)
A sample was produced in the same manner as in Example 1 except that a hydroxyapatite sintered body having a porosity of 39.9% was used.
[0112]
(Sample 3)
A sample was prepared in the same manner as in Example 1 except that a hydroxyapatite sintered body having a porosity of 48.9% was used.
[0113]
(Sample 4)
A sample was prepared in the same manner as in Example 1 except that a hydroxyapatite sintered body having a porosity of 49.9% was used.
[0114]
3. Flow test
For each of the samples 1 to 4, a liquid passing test was performed as follows.
[0115]
First, each sample was stored (installed) in the sample storage section as described above.
[0116]
Next, the three-way stopcock and the two valves were all opened, and distilled water was injected into the liquid storage container.
[0117]
Next, the vacuum pump was operated, and when the distilled water flowed into the second flow path pipe, the opening degree of the valve near the vacuum pump was adjusted to set the pressure in the apparatus to −60 kPa.
[0118]
Next, the connection port of the three-way cock to which the vacuum gauge was connected was closed.
Next, when the distilled water started to flow into the liquid recovery container, the operation of the vacuum pump was stopped once, and the liquid was replaced with another liquid recovery container.
[0119]
Next, the vacuum pump was operated again, and distilled water was collected in the liquid collecting container for a predetermined time.
[0120]
Next, the weight of the collected distilled water was measured, and the amount of distilled water that passed through the sample per minute, that is, the amount of passed water was determined.
[0121]
The time for collecting distilled water (flowing time of distilled water) was set to 3, 9, and 12 minutes for each of the samples 1 to 4, and each of the samples was passed three times (a total of nine times). The liquid volume was measured.
[0122]
Further, the weight of distilled water was determined by measuring the weight of the liquid recovery container from which distilled water was recovered, and taring (subtracting the weight of the empty liquid recovery container).
[0123]
Table 1 shows the results together with the porosity of the hydroxyapatite sintered body. In addition, the value of the liquid passing amount in each of the samples 1 to 4 is an average value of nine times.
[0124]
[Table 1]

[0125]
As is clear from Table 1, it was confirmed that the flow rate of the sample increased as the porosity of the sintered body increased.
[0126]
Further, in the liquid passage test device manufactured in the present example, the exchange of the sample was extremely easy, and the exchange of the sample could be performed in a short time.
[0127]
【The invention's effect】
As described above, according to the present invention, the test object can be replaced in a short time without using an organic solvent harmful to the human body.
[0128]
Therefore, it is possible to efficiently perform a fluid passage test on many test objects.
[0129]
In addition, since it is easy to set the test conditions to be constant among the test objects, there is little variation in the test results, and accurate test results can be obtained.
[Brief description of the drawings]
FIG. 1 is a schematic view showing an embodiment of a fluid passage test apparatus of the present invention.
FIG. 2 is a longitudinal sectional view of the vicinity of a sample storage part provided in the fluid passage test apparatus shown in FIG.
FIG. 3 is a perspective view showing a sample subjected to a fluid passage test of the present invention.
[Explanation of symbols]
1 Liquid passage test device
2 Liquid storage container
21 bottom
22 Liquid outlet
23 Filter
3 Sample storage
31 first holding unit
311 Contact member
312 Outer member
313 recess
32 Second holding unit
321 contact member
322 outer member
323 recess
33 Holding force increasing means
34 first joining member
341 screw groove
35 Second joining member
351 thread
4 Liquid collection container
41 Upper opening
42 stopper
421 Hole for channel pipe
422 Connection pipe hole
5 vacuum pump
6. First flow path pipe
60 first flow path
7 Second channel pipe
70 Second flow path
8 liquid
9 samples
90 Coating
901 Inlet
902 outlet
10 Connecting pipe
11 Three-way cock
111 Connection port
12 Connecting pipe
13 Vacuum gauge
14 valve
15 Valve

Claims (18)

A first holding unit;
A second holding unit for holding a liquid-permeable or gas-permeable test object between the first holding unit and the first holding unit;
A first flow path provided on the first holding unit side;
A second flow path provided on the second holding portion side,
In a state where the test object is held by the first holding unit and the second holding unit, a fluid is supplied to the test object via the first flow path and passes through the test object. A fluid passing test apparatus configured to collect the fluid that has flowed out through the second flow path. A first holding unit having a first flow path;
A second holding portion that holds the test object between the first holding portion and the second holding portion;
In a state where the test object is held by the first holding unit and the second holding unit, a fluid is supplied to the test object via the first flow path and passes through the test object. A fluid passing test apparatus configured to collect the fluid that has flowed out through the second flow path. A holding force increasing unit that increases a holding force of the test object by the first holding unit and the second holding unit by bringing the first holding unit and the second holding unit close to each other. Item 3. A fluid passage test apparatus according to item 1 or 2. A first joining member provided outside the first holding portion and rotatable about the first flow path as a rotation center;
The fluid according to any one of claims 1 to 3, wherein the fluid is connectable to the first joint by screwing, and includes a second joint member provided outside the second holding unit. Pass test equipment. The test object has at least the first flow path and the second flow path in a state where the test object is held on the outer surface by the first holding portion and the second holding portion. The fluid passage test device according to any one of claims 1 to 4, further comprising a coating formed having a portion having a fluid blocking property, the portion being formed except a portion facing the fluid. The first holding unit and the second holding unit are configured to contact the test object in a state where the test object is held by the first holding unit and the second holding unit, respectively. Having a member and an outer member provided outside the contact member,
The fluid passage test device according to claim 1, wherein the contact member is made of a material that is more flexible than the outer member. The fluid passage test device according to any one of claims 1 to 6, further comprising: a fluid collection container that has a space that communicates with the second flow path and that collects the fluid that has flowed through the test object. . 8. A pressure reducing device according to claim 1, further comprising a pressure reducing unit configured to reduce a pressure inside the fluid passage test apparatus in a state where the specimen is held by the first holding unit and the second holding unit. The fluid passage test apparatus according to the above. In a state where the test object is held by the first holding unit and the second holding unit, a pressure reducing unit that reduces a pressure inside the fluid passage test device is provided, and the pressure reducing unit includes the fluid The fluid passage test device according to claim 7, wherein the fluid passage test device is provided on the downstream side of the collection container, and the pressure inside the fluid collection container is reduced by depressurizing the inside of the fluid collection container. The fluid passage test device according to claim 8, further comprising a pressure adjusting unit capable of adjusting a pressure in the fluid passage test device when the pressure is reduced. The fluid according to any one of claims 1 to 10, further comprising a pressure detection unit connected to the middle of the first flow passage or the middle of the second flow passage, and configured to detect a pressure in the fluid passage test device. Pass test equipment. The fluid passage test device according to any one of claims 1 to 11, further comprising a fluid storage container having a space communicating with the first flow path and storing the fluid. The fluid passage test device according to claim 12, wherein the fluid storage container has a filter that removes foreign matter from the fluid. The fluid passage test apparatus according to any one of claims 1 to 13, wherein a characteristic of the test object can be known by checking a liquid permeability or a gas permeability of the test object. The fluid passage test device according to any one of claims 1 to 14, wherein the fluid is a liquid. A fluid passage test method using the fluid passage test apparatus according to any one of claims 1 to 15. A liquid-permeable or gas-permeable specimen is held by being sandwiched from both sides by a pair of flow pipes, and a fluid is supplied to the specimen from one of the flow pipes and passed through the specimen. And recovering the fluid flowing out of the other flow path pipe. The test object having a plurality of different conditions is replaced, and the liquid permeability or air permeability of each of the test objects is checked. From the difference in liquid permeability or air permeability between the test objects, the test object is determined. The fluid passage test method according to claim 16 or 17, wherein a relative relationship of the condition among the conditions can be known.

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