JP2003521071A - Integrated access to biomedical resources - Google Patents

Abstract

(57) Abstract A system and method are provided for performing genomic research via online analysis of genomic data objects. New technical information models and implementation mechanisms combine genomic visualization and analysis tools with the ability to link genomic data objects across (and within) multiple databases. This provides for interactivity that was not possible using traditional Internet access processes, and for data integration that further enhances the effectiveness of genomic research. The business process controls how the database is accessed, especially commercial paid databases, so that researchers using the system according to the invention do not have to be involved in tracking access restrictions.

Description

Description: BACKGROUND OF THE INVENTION FIELD OF THE INVENTION The present invention relates generally to the field of data processing. More specifically, the present invention provides
In order to increase the efficiency of nom research, a variety of biochemical data
The use of the Internet to access resources. [0002] 2. Background information Nearly every cell in every organism makes up that organism throughout its lifetime.
Including a complete set of instructions for issuing and regulating its cell structure and activity
I have. This set of instructions is called the genome. [0003] The genome is composed of distinct microscopic units called chromosomes.
ing. Chromosomes are coiled threads of deoxyribonucleic acid (DNA).
Each strand of DNA is wound together to form two long, double-helix pairs.
Consists of a chain of nucleotides. The human genome consists of these 3.5 billion pairs of nucleotides
Be composed. [0004] A given DNA strand contains cellular instructions for producing a protein. this
These instructions are based on the specific sequence of nucleotide bases, called genes, in the DNA strand.
Take shape. Scientists find that these 80,000 to 100,000 basic genetic units
Is presumed to be present in the human genome. Proteins have a wide variety of physiology
Work. These include digestion and respiration, immune response, heat and energy production
Facilitates processes such as the movement of fluids inside and outside the cell. [0005] Most members of some species have the same set of genes. However, each individual German
Its own characteristics arise from slight variations in the nucleotide sequence containing the gene of the individual.
I will. These slight genetic variations that define an individual's unique characteristics are called polymorphisms.
It is. On average, the DNA of any two individuals of a species differ by about 0.1%.
Will be. [0006] Another class of mutations, called mutations, also occur. Polymorphic and mutagenic mutations
Both differ, either inhibiting the production of the protein or altering the normal function of the protein
May be harmful to the individual. Most diseases are
Resulting from genetic variation in ip. [0007] Genomics is the study of nucleic acid sequences in the genome. The purpose of genome research is
Determine the sequence of leotides, understand the function of all the genes they contain, and
The purpose is to clarify the genetic variation that produces a defined disease. [0008] Genomics has a wide range of applications. These are the most basic of the research work
It applies from simple matters to prospects of being useful for diagnosis. An important factor limiting new drug development is that new drugs can be developed for it
The number of known target molecules is limited. Disease target molecules are affected by drugs
And may cause subsequent desired biological responses in the body.
Wake up. Historically, the process of discovering new target molecules has been a trial and error process.
It was extremely slow and very expensive because it relied on discovery techniques. Genome research
Relies on trial and error because drug designers can go directly to the target molecule in question.
Will be reduced. Therefore, genomic research should be applied to drug development.
Thus, new and better drugs are produced more quickly and at lower cost. [0010] Another way genomic research can help the pharmaceutical industry is to introduce new approaches to pharmacogenomics.
In the entertainment field. Pharmacogenomics is developing more personalized drug therapies.
Effect of drug treatment-i.e., how well an individual absorbs a particular drug and
Whether to metabolize the drug-to identify genetic variations among patients that may affect
Focused. Almost all pharmaceutical companies find that a given drug has the same effect on all people
In response to the growing evidence that it does not exert
Is developing. In particular, pharmacogenomics is considered to provide at least three different useful applications.
Has been obtained. In other words, improving the success of the trial by improving the patient selection process.
And to identify new uses for existing drugs, and to identify populations more suitable for drug use, still fail drug testing.
It is to rescue drugs that have been used. Drug candidates to be rescued
Includes those that have resulted in rejection in the population. [0012] Molecular toxicology is another area of technology that can benefit from genomic research.
About 2.2 million Americans are hospitalized each year as a result of the adverse side effects of drugs. This
Harmful (and often due to unpredictable effects) such as
More than one American has died. For example, some cause liver damage,
Some are harmful to the kidneys. Organ-specific genes for drugs already available
Expression profiles allow researchers to more reliably investigate the toxicity of new drug compounds.
And become possible. Furthermore, gene expression data combined with polymorphism information related to metabolic pathways
Key indicators of how individual patients respond to different dosage levels of the drug.
And thereby significantly reduce the undesirable side effects of the treatment. [0014] Risk assessment is a major area of diagnosis that benefits from genomics
. Historically, predicting whether someone is at particular risk for a particular disease
Focuses on measuring general physical indicators such as blood pressure and cholesterol levels
It is guessing. While these measurements reflect general physiological phenomena,
Does not provide specific genetic basis for the elderly's disease. As a result, these
Diagnostic Tests Could Not Identify Root Cause of Disease, Threatening Medical Care for Patients
And may increase the risk of litigation. [0015] New genome-based diagnostics will identify patients with specific genes and diseases.
By looking at every change, you can determine the individual risk of a particular disease.
And will focus on These new diagnoses suggest that certain diseases
By providing a more accurate assessment of the patient's potential risk,
It is likely that much better preventive care will be possible. [0016] Personalized medicine is another major area of diagnosis that benefits from genomics.
Genomic information is used to develop molecular diagnostic tests that identify individual genetic components.
Available. These diagnostic tests allow the physician to establish a therapy for each patient.
Can revolutionize healthcare, that is, enable personalized healthcare
is there. For example, many types of cancer, each distinctly different at the cellular level,
Nevertheless, they show similar symptoms. Symptoms include one genetic type of cancer and another
Because cancer may be similar, prescribing effective treatments involves cancer genes and
It is important to know as much as possible about those interactions. [0018] As another example, physicians select the most effective drugs with minimal side effects.
Molecular / genomic testing can be used to help. As a result, this
The technique allows patients to receive personalized medicine and shortens the duration of illness
So that you can ultimately live a better and longer life
Become. In addition to health care, the field of agriculture will also benefit from genomic research. Plants
And animal diseases, and provide treatments targeting those diseases.
Being able to develop will produce better produce and increase yields
I do. For example, genetic information from disease-resistant or pest-resistant plant strains and non-resistant strains
By using selective breeding programs for comparison and favorable traits,
Significantly increase the number of new strains available in various agricultural areas around the world, and
Such new strains can be very successful. This increases the amount of food
It has important implications, not only to increase the nutritional quality of the food, but also to increase it. Other areas that may benefit significantly from genomic information include forensic medicine,
Includes veterinary medicine, textile production, waste control and environmental improvement. In achieving any of the aforementioned beneficial results predicted for genomic studies,
A new obstacle is the overall magnitude of the amount of genomic information that is being screened and studied.
That's it. Available exotic, not exaggerated, whole screened and studied
Nucleic acid sequence data is unimaginably vast. In addition, newly sequenced
Since the DNA strands are sequentially recorded, the data itself becomes larger every day (virtually). Get
Due to the huge amount of nom data, this is stored and processed via a computer.
Is operated. Bioinformatics is a system for searching, processing, and analyzing biological information.
Is to use a computer. This field of data processing is currently
Considered important for discovery and development. Scientists call the traditional “wet”
t) "Biology, quantitative analysis, database comparison, and computer algorithm
Rhythm makes up. In this way, biological research can be done at least in advance in a virtual environment.
Done, and then the scientists actually do it in the lab. Bioinformatics tools
Tools and services include gene discovery, understanding of disease pathways, identification of new disease targets,
Drug discovery, including discovery and correlation of gene sequence mutations for disease and disease
Assist pharmaceutical and biotechnology researchers at all stages of development and development
You. Unfortunately, the traditional means of accessing genomic information has been to make the data computationally transparent
For comprehensive and easy access that can be analyzed or studied in a simple manner
Not. Genomic information is stored in a wide variety of databases, some of which are
Is public (available for free), some are commercial (available for a fee), some are
Is a manufacturer's own ("in-company" resources that are not shared with outsiders). Referring to FIG. 1, a public 102 and dedicated 104 genomic database, such as
A search tool 106 is available online. User 110
Databases 102, 104 and search using the interface device 112
Access the tool 106. The interface device 112
Access portal site 120 via an Internet connection 130
You. Portal 120 provides access to databases 102, 104 and search tool 106.
The connection is made via the Internet 140. User 110 is a genome research resource
Another mode of operation for accessing the
Does not use the portal 120 via the Internet connection. (This
The simplified connection mode is not shown). Interface device 11
2 is typically an implementation of a thin client browser application. Each database consists of data objects containing biological data. De
Data objects are the type of biological data they contain for each database.
And with regard to their format. Therefore, multiple data
For research on data from databases, researchers are presented in a unique data structure.
Learn how to interpret the data and the data content of each particular database
is necessary. This is a significant disadvantage. Therefore, what is needed is a variety of genomic databases (each of which is
Data (including genomic data objects in different formats)
Dynamically interpreted and presented to the user in a predictable and easily recognizable format
To be a bioinformatics visualization tool. In addition, various storage formats are used by different databases.
A large number of data objects that are analyzed using automated analysis tools.
From these proprietary formats, a format that allows the automated analysis tools used to be recognized.
Format. This is even more inconvenient. Therefore, what is needed is a diverse genomic database (each of which is
Data (including genomic data objects in different formats)
Translates dynamically so that it is presented to the parser in a uniform format
A bioinformatics software tool. Further, it has been discovered that pairs of data objects have a significant relationship to each other.
When done, conventional mechanisms for establishing linking relationships between them (
(Other than manually writing the note to itself). Such a mechanism is
, Pairs of data objects originate in two completely different databases
When seen, it is most not absent. Therefore, what is needed is a data object with a diverse database.
From a variety of formats and content types
Even the user establishes a linking relationship between these data objects
Is a software mechanism that can In addition, the Internet database host or central
Hyper text markup language provided by the Internet portal
Access and Navigate Word (HTML) Genome Data Files
Existing methods have significant limitations. For one thing, data manipulation and / or
There is no interactivity possible for analysis. This interactivity is
The consequences are significant. Therefore, what is needed is for the user to have the genomic data file
Via the Internet, these files are in the form of HTML (usually done)
Whether it is an expression or some other format that can display data
Software that can be accessed and navigated interactively
It is a wear mechanism. SUMMARY OF THE INVENTION [0033] It is an object of the present invention to convert data into a variety of genomic databases (each with a different
Data (including genomic data objects)
And present it to the user in a predictable and easily recognizable format.
To provide a bioinformatics visualization tool. Another object of the present invention is to provide a variety of genomic databases, each with a different
Format (including genomic data objects)
Translation, so that it is presented to the parser in a uniform format
Provide Io Informatics software processes and systems
That is. Still another object of the present invention is to provide a method for storing data objects in various databases.
From a variety of formats and content types
Even the user establishes a linking relationship between these data objects
To provide software processes and systems that can Yet another object of the present invention is to allow a user to use HTML (or other format).
G) Genome data files via the Internet
Software processes that can access and navigate
And provide systems. A further object of the present invention is to provide seamless access to multiple genomic databases.
Access and interactivity to one or more of their databases
To enable it even if it is a commercial (ie, paid) database
Business process. Some of the above objectives include a local genome database system,
And electronically communicate with one or more remote genome database systems.
Is enabled by the trusting data processing system. This data processing system
Allows users to graphically display genomic data objects
Includes graphical user interface. This is also genomic data
Object linker and one or more genomic data objects
Contains a linkable data object resolver that resolves
The project consists of a local genome database system and one or more
Data objects found in remote genome database system
Linkable for the target genomic data object from within the project
You. Resolved objects resolved by the Linkable Data Object Resolver
Nom data objects are processed by the data object linker
Resolved genomic data object linked to nom data object
And the target genomic data object are graphical user
Will be provided to the interface. Some of the above objectives also include a local genome database system.
And one or more remote genome database systems and electronics
It is also made possible by a system for performing genomic research, which communicates dynamically.
The system provides users with a graphical view of genomic data objects.
Means to present genomic data objects and link them to each other.
Means. The system also stores genomic data objects in raw
Cal Genome Database System and One or More Remote Geno
Genome Data Objects Discovered in the System Database System
Means for resolving a genomic data object of interest from within
The resolved genomic data object resolved by the resolving means
Linked to the target genomic data object by
Nom data object and target genome data object
And provided to the means for printing. [0040] Another method that enables some of the above objectives involves genomic research.
Local genome database and
And one or more remote genome databases as resources
Depending on the method of execution. This method uses linkable genomic data
Objects are stored in a local genome database system and one or more
Target genome data from multiple remote genome database systems
For data objects, the data format of the genomic data object
Including the operation to solve regardless of the mat. In addition, this method is
Data objects to linkable genomic data objects
And forming a set of linked genomic data objects. Sa
In addition, this method uses a local set of linked genomic data objects.
-Includes storing in the genome database. Yet another method that enables some of the above objectives is the Genome Lab.
Computer system implementing the method as described above for use in research.
It depends on the system. One of the above objectives is enabled by the new technical information model and enforcement mechanism
It is said. It provides genomic visualization and analysis tools to genomic data objects.
The ability to link projects across (and within) multiple databases
Implemented by combining. Another of the above objectives is to control access to multiple genomic databases.
In this case, the genomic database is
Nom database, public genomic database and commercial genomic database
Including This method links the linkable data object to the target data object.
Steps to resolve for the object, and further resolved data objects
Linking the data to the target genomic data object. Official Geno
Linkable data objects that are resolved from the
Regardless of the data format of the genomic data object stored in
Solved, no restrictions on access costs. Commercial Genome Database
Linkable data objects that are resolved from the
Is resolved regardless of the data format of the
Resolved by applying applicable prescribed access agreements for nom databases
Is done. Yet another way in which some of the above objects are enabled is a computer
Controllers that can control access to multiple genomic databases.
Depends on Pewter Program product. Multiple genomic databases are
Genome database, public genome database and commercial genome database
Including Computer program products allow computers to perform specified operations.
Software instructions to enable
Computer readable medium. The predetermined operation includes the operation according to the method described above.
It is. One aspect of the present invention is a nucleic acid sequence, amino acid sequence, oligonucleotide, Basi
c Local Aligned Search Tool (BLAST) search
Results, and entries from medical databases such as MEDLINE
A local database for storing nom data. Another aspect of the present invention is a visualization and analysis mechanism. Visualization and analysis are preferred
Or provided via a dialog box, to set parameters for BLAST search.
Configurable so that text-based searches consist of sequence databases
And search for documents can be performed in a database.
The linker uses nucleic acid sequences, amino acid sequences, BLAST search results,
Included to link birds and the like together. All types of genomic / biomedical
The information is displayed in a graphical interface that incorporates viewer and editor components.
Visualized through the interface. [0047] Yet another aspect of the invention is a link between database objects.
Internet connector having a programming module that solves
You. This connector can be a local database or a remote Internet
Check the server to get the required data object. [0048] Additional objects and advantages of the invention will be set forth in the following detailed description taken in conjunction with the accompanying drawings.
It will be clear from that. DETAILED DESCRIPTION OF THE INVENTION One way to consider the present invention is to use a thin client browser and a thin client browser.
Use the portal (see Figure 1) to give researchers access to genomic research resources
Is to be abandoned. Instead, the applicant
Increases the effectiveness of systems that provide a tactical interface with resources
I discovered that. This interactivity is needed to increase the effectiveness of genomic research
is important. Another method of considering the present invention is a technical information model and an implementation machine.
It is as a composition. An aspect of the interactivity of the present invention is the data object
And a combination of aspects of its visualization and analysis. In addition to the local database for storing intermediate and final results,
Ming has aspects of visualization and analysis. Visualizations are provided in an advanced format,
This is a graphical tool that intuitively appeals sequences and other molecules to human perception.
This is shown in the presentation. In addition to interactivity,
Users can easily integrate (ie, link) data and localize the integrated data.
The ability to store in a database is very useful. The additional functionality provided in the preferred embodiment of the present invention
A file that can be used directly in the user interface rather than through the Internet
A small scale analysis tool and algorithm. For full-scale analysis, DN
A for protein, enzyme and oligo data set, BLAST results, MED
It can be evaluated in view of LINE Entrez data and amino acids. A software product that can provide the visualization and analysis aspects of the present invention.
One embodiment is the InformM from North Bethesda, Maryland.
ax, Inc. Vector NTI ™ product. Another aspect according to a preferred embodiment of the present invention is via the Internet
Multiple databases (eg, NCBI, Entrez, PubMed, SR
Provide an integrated database search using a solution system that contacts S)
Is Rukoto. Referring to FIG. 2, the public 202 and dedicated 204 databases, and various
Various research tools 206 are available online. Also, as a research resource
What is available is that user 210 has access to local database system 208
These are the research results before storage and data unique to other manufacturers. Like the prior art
In addition, the Internet 220 has various remote resources 202, 204, 20
6 to be used as a communication medium for accessing. However, in contrast to the prior art
Typically, a completely different set of tools is used to conduct the research. A user 210 utilizes a user interface 230, which is a visualization system.
System 232 and the data set linking mechanism 234 (hereinafter referred to as “linker”).
"). Linker 234 allows users to further study in relation to each other
To consolidate data sets that you consider worth associating
. The data set so linked contains the analysis tools and algorithm 2
40 can be used to more closely inspect or analyze. Used with the present invention
Examples of useful analysis tools and algorithms to include for use are BioP
lot ™, AlignX ™, and ContigExpress ™ (trademarks).
All of these are North Bethesda, MD's Infor
Max, Inc. Products. Some other available solutions, such as BLAST
Analysis tools can also be used effectively. This inspection and analysis procedure describes itself as the source data from which they were derived.
The result is that you can link to the set. Local database 208
Used, integrated data sets and results for later studies
210 or its colleagues. Later research, additional computer solutions
Analysis can be in the form of an analysis or if the results are deemed promising enough
If so, it can be in a biological laboratory. Candidates for linking include linkable data object resolution systems.
Identified by the program 250. Linkable data object resolution system
250 provides various search tools 206 and data via the Internet 220
Accessing either of the bases 202, 204, the user 210 may be interested in
Data object associated with the target data object identified as
Explore about Resolution system 250 does not establish a link. Rather, the solution
System 250 is an enormous amount of data that can be used for browsing over the Internet.
Data collection should have reasonable probabilities associated with the data object of interest.
Identify data objects To limit and guide the search by the resolution system 250,
The accounting and accounting module 260 accesses the resolution system 250
Public 202 or commercial databases 204 with established agreements
To access only the database you want to access. Permission and
The accounting aspect of the accounting module 260 is based on commercial data.
Maintain access time, duration and authorization records for use of base 204
Carry. In addition to the apparatus aspects of the present invention, the methods also form some aspects of the present invention. Book
A method for performing genomic research according to the invention is first described in Linkable Genome Data.
By resolving the data objects, the linkable genomic data
Data object with the target genomic data object
This is performed by forming a set of pre-processed genomic data objects.
The resolution operation is performed on one or more resources with respect to the target genomic data object.
It is performed using the mote genome database as a resource. option
The Local Genome Database is Linkable Genome Data Object
Used in project resolution. The resolution operation is based on the genomic data object.
This is performed regardless of the data format of the genomic data.
This is because the object may be found in various databases.
After the genomic data objects are linked, they are linked to the genomic data.
Data objects stored in the local genome database.
preferable. Another aspect of the invention is to represent a business process, where
Predetermined access arrangements for commercial databases guide research steps
Access to these databases is used to
It is completely seamless from the point of view of the researcher / user using it. As a result,
, Multiple commercial and local (sometimes proprietary) genomic data
It is the process of managing access to the database. This process is linkable
Steps to resolve the data object with respect to the target data object
And the resolved data object to the target genome data object.
Linking the project. Resolved from public genome database
Linkable data objects are genomic data objects stored within them.
Resolves regardless of the object's data format and reduces access costs.
There are no restrictions. Linkable Day Resolved from Commercial Genome Database
Data object is the data of the genomic data object stored in it.
Data regardless of the data format, and
Resolved upon receipt of an available predetermined access agreement. Although the present invention has been described with reference to preferred embodiments, various modifications and improvements have been described.
What can be done in the embodiments described without departing from the scope of the invention
Will be understood. The scope of the present invention is limited by the appended claims. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an Internet database resource through a portal using a browser.
FIG. 2 is a diagram illustrating a conventional configuration for accessing a source. FIG. 2 illustrates the integration of Internet database resources according to one embodiment of the present invention.
It is a figure which illustrates combined access.

[Procedure amendment] [Submission date] August 26, 2002 (2002.8.26) [Procedure amendment 1] [Document name to be amended] Description [Item name to be amended] Claims [Amendment method] A data processing system that communicates with a local database system and communicates with one or more remote database systems, wherein the user has data. A graphical user interface capable of graphically displaying objects, a data object linker, and a linkable data object resolver for resolving one or more data objects, the objects comprising: Local database
A resolved data object that is linkable with respect to a target data object from among the data objects found in the system and one or more remote database systems, and that is resolved by the linkable data object resolver. A data processing system linked to a target data object by a data object linker, wherein the resolved data object and the target data object are each provided to a graphical user interface. 2. A data processing system in electronic communication with a local genomic database system and electronically with one or more remote genomic database systems, wherein a user is provided with genomic data. A graphical user interface capable of graphically displaying objects, a genomic data object linker, and a linkable data object resolver for resolving one or more genomic data objects; The object is linkable with respect to the target genomic data object from among the data objects found in the local genomic database system and one or more remote genomic database systems, The resolved genomic data object resolved by the linkable data object resolver is linked to the target genomic data object by the data object linker, and the resolved genomic data object and the target genomic data object are resolved. Each object is a graphical user
Data processing system provided to the interface. 3. The data processing system according to claim 2, wherein the data processing system communicates with one or more remote genome database systems via a network. 4. The data processing system of claim 2, wherein the data processing system communicates with one or more remote genome database systems via a network of networks. 5. The data processing system according to claim 2, wherein the data processing system communicates with one or more remote genome database systems via the Internet. 6. The resolved genomic data object and the target genomic data object are each of a data type selected from the group consisting of nucleic acid sequences, amino acid sequences, oligonucleotides, BLAST search results, and medical data. The data processing system according to claim 2, wherein 7. The data processing system of claim 6, wherein the resolved genomic data object and the target genomic data object are of different data types. 8. The local genomic database system and one or more remote genomic database systems are each selected from the group consisting of nucleic acid sequences, amino acid sequences, oligonucleotides, BLAST search results, and medical data. 3. The data processing system of claim 2, wherein the data processing system includes data objects of different types. 9. The data processing system according to claim 2, wherein the graphical user interface has a function of graphically displaying a nucleic acid sequence, an amino acid sequence, an oligonucleotide, a BLAST search result, and medical data. 10. The data processing system of claim 2, wherein the genomic data object linker links genomic data objects of different data types. 11. A system for performing genomic research, the system electronically communicating with a local genomic database system and electronically communicating with one or more remote genomic database systems. Means for presenting a graphical view of genomic data objects to a user, means for linking genomic data objects to each other, genomic data objects to a local genomic database system and one Or a means for resolving the target genomic data object from among the genomic data objects found in the plurality of remote genomic database systems, and the resolved genomic data solved by the resolving means.・ If the object is System for linked to the target genomic data objects by click to means, resolved genomic data object and target genomic data object is provided to means for presenting each executes genomic research. 12. The system for performing genomic research according to claim 11, wherein the system is in communication with one or more remote genomic database systems via the Internet. 13. The resolved genomic data object and the resolved genomic data object of interest are data selected from the group consisting of a nucleic acid sequence, an amino acid sequence, an oligonucleotide, a BLAST search result, and medical data, respectively. 12. A system for performing genomic research according to claim 11, wherein the system is of the type. 14. The resolved genomic data object and the resolved genomic data object of interest are of different data types.
4. A system for performing a genomic study according to 3. 15. The local genomic database system and one or more remote genomic database systems each comprise a nucleic acid sequence,
2. A data object of a type selected from the group consisting of amino acid sequences, oligonucleotides, BLAST search results and medical data.
2. A system for performing a genomic study according to 1. 16. The system for performing a genomic study according to claim 11, wherein the means for presenting has a function of graphically displaying a nucleic acid sequence, an amino acid sequence, an oligonucleotide, a BLAST search result, and medical data. 17. The system for performing genomic research according to claim 11, wherein the linking means links genomic data objects that are of different data types. 18. A computer system adapted for genomic research on a subject genomic data object using a local genomic database and a remote genomic database as resources, comprising: a processor; and a memory; This memory communicates electronically with the processor to store the Linkable Genome Data Objects from the Local Genome Database and the Remote Genome Database from the target Genome Data.
Resolving the object, irrespective of the data format of the genomic data object, linking the target genomic data object to the linkable genomic data object, and setting the linked genomic data object And a software instruction adapted to enable the computer system to perform the steps of forming a set of linked genomic data objects in a local genomic database. 19. A method for performing a genomic study on a genomic data object of interest using a local genomic database and one or more remote genomic databases as a resource, comprising: linkable genomic data; Resolving the object with respect to the subject genomic data object from the local genomic database and one or more remote genomic databases, regardless of the data format of the genomic data object; Linking the target genomic data object to a linkable genomic data object to form a set of linked genomic data objects; and linking the set of linked genomic data objects to a local genomic data object. A method for performing genomic research, including storing in a genomic database. 20. The resolved genome data object and the target genome
20. The method of performing genomic studies according to claim 19, wherein the data objects are each of a data type selected from the group consisting of nucleic acid sequences, amino acid sequences, oligonucleotides, BLAST search results, and medical data. 21. The resolved genome data object and the target genome
21. The method of performing genomic research according to claim 20, wherein the data objects are of different data types. 22. The system of claim 1, wherein the local genome database system and the one or more remote genome database systems each comprise a nucleic acid sequence,
2. A data object of a type selected from the group consisting of amino acid sequences, oligonucleotides, BLAST search results and medical data.
10. A method for performing a genomic study according to 9. 23. A method for providing a graphical user interface to associate a genomic data object and a resolved genomic data object with nucleic acid sequences, amino acid sequences, oligonucleotides, BLAST search results or medical data. 20. The method of performing genomic research according to claim 19, further comprising graphically indicating whether or not there is. 24. The method of performing genomic research according to claim 19, wherein the linking operation links genomic data objects that are of different data types. 25. A method for managing access to a plurality of genomic databases, wherein the plurality of genomic databases includes a local genomic database, a public genomic database, and a commercial genomic database, Resolving a linkable data object with respect to a target data object; and linking one or more resolved data objects to said target genomic data object, comprising: one or more linkable data; Objects are resolved from a public genomic database, regardless of the data format of the genomic data objects stored therein, without restrictions on access costs, and one or more linkable data objects are Access to multiple genomic databases from a genomic database for use, irrespective of the data format of the genomic data objects stored in it, with a predetermined access agreement for a commercial genomic database How to manage. 26. The resolved genome data object and the target genome
26. The method according to claim 25, wherein the data objects are each of a data type selected from the group consisting of nucleic acid sequences, amino acid sequences, oligonucleotides, BLAST search results, and medical data. How to manage access. 27. The resolved genome data object and the target genome
27. The method of managing access to multiple genomic databases according to claim 26, wherein the data objects are of different data types. 28. The method according to claim 28, wherein the local genome database system and the one or more remote genome database systems each comprise a nucleic acid sequence,
3. A data object of a type selected from the group consisting of amino acid sequences, oligonucleotides, BLAST search results and medical data.
6. The method for managing access to a plurality of genome databases according to 5. 29. Providing a graphical user interface to associate a genomic data object and a resolved genomic data object with nucleic acid sequences, amino acid sequences, oligonucleotides, BLAST search results or medical data. 26. The method of managing access to a plurality of genomic databases according to claim 25, further comprising graphically indicating whether or not there is. 30. A method according to claim 25, wherein the linking operation links genomic data objects of different data types.
How to manage access to the database. 31. A computer program product for enabling a computer to perform a genomic study on a genomic data object of interest using a local genomic database and a remote genomic database as resources. , Including software instructions for enabling a computer to perform predetermined operations, and computer readable media for performing the software instructions, wherein the predetermined operations include linkable genomic data objects, local genomic databases and Target genomic data from remote genomic database
Regarding the object, regardless of the data format of the genomic data object, the operation to solve and link the target genomic data object to the linkable genomic data object, and set the linked genomic data object And storing the set of linked genomic data objects in a local genomic database. 32. A computer program product for enabling a computer to manage access to a plurality of genomic databases, the plurality of genomic databases comprising a local genomic database, a public genomic database, and a commercial genomic database. A software instruction for enabling a computer to perform a predetermined operation, including a genomic database; and a computer-readable medium for implementing the software instruction, wherein the predetermined operation comprises one or more linkable data objects. Solving for the target data object; and linking one or more resolved data objects to the target genome data object, wherein the one or more linkable data objects are From a database, regardless of the data format of the genomic data objects stored therein, without any restrictions on access costs; one or more linkable data objects can be retrieved from a commercial genomic database , A computer program product that is resolved with predetermined access arrangements for a commercial genomic database, regardless of the data format of the genomic data objects stored therein. 33. A data processing system in electronic communication with a local genomic database system and in electronic communication with one or more remote genomic database systems, wherein a user is provided with genomic data. A graphical user interface capable of graphically displaying objects, a genomic data object linker, and a linkable data object resolver for resolving one or more genomic data objects; The object is linkable with respect to the target genomic data object from among the data objects found in the local genomic database system and one or more remote genomic database systems. And one or more genomic analysis tools integrated into the graphical user interface, wherein the resolved genomic data objects resolved by the linkable data object resolver are combined with the data object linker. Linked to the target genomic data object, and the resolved genomic data object and the target genomic data object
A data processing system provided to the interface and adapted for analysis via one or more genomic analysis tools.

Claims (1)

Claims 1. A data processing system in communication with a local database system and with one or more remote database systems, wherein a user graphically displays data objects. A graphical user interface, a data object linker, and a linkable data object resolver for resolving one or more data objects, the objects comprising a local database database.
A resolved data object that is linkable with respect to a target data object from among the data objects found in the system and one or more remote database systems, and that is resolved by the linkable data object resolver. A data processing system linked to a target data object by a data object linker, wherein the resolved data object and the target data object are each provided to a graphical user interface.