JP2003212774A - Maillard reaction inhibitor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new safe Maillard reaction inhibitor, a cosmetic composition, a drink, or a food. <P>SOLUTION: This Maillard reaction inhibitor is characterized by containing one or more compounds selected from the group consisting of phenylpropanoids (trans-cinnamic acid, para-coumaric acid, ferulic acid, or the like), chalcones (phloretin or the like), benzene derivatives (salicylic acid, benzoic acid, para- hydroxybenzoic acid, or the like). A skin care preparation, a drink or a food. The Maillard reaction inhibitor can be utilized for inhibiting the Maillard reaction, further imparts gloss and tension to skin, is effective for preventing and treating dry skin, can be used for preventing and treating Maillard reaction- related diseases such as skin elasticity-deteriorating phenomena, for example, the wrinkles, looseness and drabness of the skin, and the browning of the skin, the ageing of the skin, and complications originated from diabetes, and can further be expected to have an aging-resistant effect and the like. The Maillard reaction inhibitor has high safety, even when used as an internal use or external use. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a novel and safe Maillard reaction inhibitor, and further to application to a skin external preparation or a food or drink, which can be expected to have an antiaging effect and the like.

[0002] The field of use thereof is, for example, all kinds of internal and external preparations (including preparations used for animals) in general, and specifically, ampoules, capsules, pills, tablets, powders, granules. , Solids, liquids, gels or air bubbles 1) pharmaceuticals, 2) quasi drugs, 3) topical or systemic skin cosmetics (for example, lotion, emulsion, cream, ointment, lotion, oil, pack) Basic cosmetics such as, facial cleansers and skin cleansers, massage agents, cleansing agents, depilatory agents, depilatory agents, shaving treatment agents, aftershave lotions, preshave lotions, shaving creams, foundations, lipsticks, blushers, eyes Makeup cosmetics such as shadow, eyeliner, mascara, perfume, nail enamel, nail enamel, nail enamel remover, poultice, plaster, tape, Agents, patches, aerosols, etc.), 4) medicinal or / and cosmetic preparations applied to the scalp / hair (for example, shampoos, rinses, treatments, permanent liquids, hair dyes, hair dressings, Hair articulation agents, hair growth and nourishing agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 5) bath agents to be used by pouring into bath water, 6) other axillary deodorants and deodorants. Examples thereof include odorants, deodorants, hygiene products, sanitary cotton, wet tissues, mouth fresheners (eg, toothpaste, mouthwash) and the like.

Further, as foods and beverages, oral compositions (gum, candy, etc.), processed fish paste products such as kamaboko and chikuwa, livestock products such as sausage and ham, western confectionery, Japanese confectionery, raw noodles, Chinese noodles, and boiled noodles. , Noodles such as buckwheat, sauce, soy sauce, sauce, sugar, honey, powdered candy,
Seasonings such as starch syrup, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, greens, sprinkles, or processed vegetables and fruits such as canned and bottled vegetables and fruits, Dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice,
It can be used for general beverages such as vegetable juice, whey beverage, soft drink, beverages such as alcoholic beverages, and other health foods.

[0004]

2. Description of the Related Art Although it is natural for all people to age as they age, in recent years, due to deterioration of environmental conditions, changes in lifestyle, increase in stress due to the complication of social life, etc. The factors that are being promoted are increasing. In particular, the importance of living in good health every day is being reassessed with the increase in the number of elderly people and the prolongation of life, and it is a long-awaited expectation for all to suppress the progress of aging.

Aging is a decrease in various functions of the body, and considering this at the cellular level, various physiological functions in the living body are controlled by proteins. That is, aging is considered to be a state in which the protein cannot exert its original function because some disorder has been given to this protein, and one of the disorders is a non-enzymatic protein glycosylation reaction. . This is a reaction that causes the original function of the protein to be impaired by the binding of the reducing sugar and the amino acid or protein, and is called the Maillard reaction (browning reaction). still,
The initial reaction product of this Maillard reaction is a conjugate of protein and sugar called Amadori compound, and further this reaction forms a fluorescent yellow-green substance through dehydration and polymerization, which becomes a terminal saccharification substance. Become.

[0006] It is speculated that the dysfunction due to glycation of proteins may be the cause of complications caused by diabetes or the development of senile dementia.

Further, the skin of a person who comes into contact with the outside world becomes wrinkled, tingled, and dull due to aging, and the gloss of the skin also decreases. This is because changes in the constituents of the dermis have a great influence, and glycation of proteins by the Maillard reaction causes cross-linking of collagen (collagen fibers) and elastin (elastic fibers). In particular, cross-linking between collagen fibers associated with protein saccharification is necessary to increase mechanical strength in the initial stage, but the number of cross-links that are not required gradually increases, causing a decrease in skin elasticity and causing wrinkles and tarmi. It is said that. Also, saccharification of proteins is expected to cause browning of the skin.

[0008] The glycation of proteins, which progresses in vivo as cellular aging, is attracting attention as a cause of skin aging, diabetic complications, and various cell disorders. However, only a handful of drugs such as aminoguanidine are known as drugs that inhibit the Maillard reaction, and the effect of inhibiting the Maillard reaction is not so strong under the present circumstances.

[0009]

In view of such circumstances, the present inventors have an excellent effect of inhibiting the Maillard reaction with the amount of pentosidine, which is one of the final Maillard reaction products, as an index, and We have tried screening for substances that do not have side effects and have continued to study new compounds.

[0010]

Therefore, the present inventors have found that transcinnamic acid, paracoumaric acid, ferulic acid classified as phenylpropanoids, phloretin classified as chalcone, and salicylic acid, benzoic acid classified as benzene derivatives. , It was confirmed that para-hydroxybenzoic acid had a pentosidine formation inhibitory effect, and it was applied as a Maillard reaction inhibitor. Furthermore, it gives the skin a glossy finish,
Improving dry skin to prevent or improve skin wrinkles and skin wrinkles and tarsiness of skin due to deterioration of skin elasticity and browning. That is, the present invention has been completed by providing a safe external preparation for skin or food and drink having an antiaging effect.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION The "phenylpropanoid" used in the present invention is a compound in which a straight chain 3 carbon is bonded to a benzene nucleus, that is, a compound having a C ₆ -C ₃ compound as a basic skeleton, A compound including its oxidation or reduction product is intended. It is classified into phenylpropanoid, coumarin, lignan, neolignan, sesquilignan, dilignan, lignin, and others. Typical examples include transcinnamic acid, paracoumaric acid, ferulic acid, chlorogenic acid, cinnamic aldehyde, coniphenyl alcohol, syringenin, dihydroconiferyl alcohol, anethole, eugenol, safrole, myristicin, steganacin, gomisin, magnolol, hinokiol. , Lysospermic acid, cassulenone, ginkgolide, asatone, lappaol, and the like, and transcinnamic acid, paracoumaric acid, and ferulic acid are particularly preferable. Also,
You may use these glycosides and derivatives.

The "transcinnamic acid" used in the present invention is a compound shown in the following chemical formula (Chemical formula 1), and a glycoside or derivative thereof may be used. Further, either a product extracted / purified from a natural product or a product obtained by a synthetic method can be used. There is no particular limitation on the purification method and the synthesis method. Examples of the plant extract containing transcinnamic acid include Anthocco Styra
x benzoides, Styrax tonkinensis, Kayupte Melaleuc
a leucadendron, cilantro Coriandrum sativum, sunflower Helianthus annuus L., broomfish Ocimum basil
icum L., etc., or these homologous plants can be used.

[0013]

[Chemical 1]

The "paracoumaric acid" used in the present invention is a compound shown in the following figure (Chemical formula 2), and its glycoside or derivative may be used. Either a product extracted / purified from a natural product or a product obtained by a synthetic method can be used. Regarding these purification methods and synthetic methods,
There is no particular limitation. Examples of plant extracts containing paracoumaric acid include rape Brassica oleracea, Catalpa bignonioides WALT., Strawberry Frag
aria spp, fennel Foeniculum vulgare MILLER, turmeric Curcuma longa L., orange Citrus sinensis
(L.) OSBECK, Grapefruit Citrus paradisi Mac F
AD., Pepper Capsicum annuum L., wheat Triticum
aestivum L., rice Oryza sativa L., Salvia Salvia
sp., potato Solanum tuberosum L., ginger Zi
ngiber officinale ROSCOE, Rheum rhabarbar
um L., Japanese radish Raphanus sativus L., soybean Glycin
e max (L.) MERR., Thymus vulgaris L., Chives Allium schoenoprasum L., Capsicum Capsicum
frutescens L., corn Zea mays L., garlic A
llium sativum var. sativum L., pineapple Ananas
comosus (L.) MERR., Peanut Arachis hypogaea
L., Sunflower Helianthus annuus L., Spinach Sp
inacia oleracea L., Mebuki Ocimum basilicum L.,
Apple Malus domestica BORKH. Etc. or these homologous plants can be used.

[0015]

[Chemical 2]

The "ferulic acid" used in the present invention is a compound shown in the following chemical formula (Chemical formula 3), and a glycoside or derivative thereof may be used. Either a product extracted / purified from a natural product or a product obtained by a synthetic method can be used. Regarding these purification methods and synthetic methods,
There is no particular limitation. As a plant extract containing ferulic acid, for example, Agi Ferula assa-foetida L., rape Brassica oleracea, orange Citrus sinensis (L.)
OSBECK, Fern Glycyrrhiza glabra, Cabbage Bras
sica oleracea var.capitatal.var.capitata L., grapefruit Citrus paradisi MacFAD., wheat Triti
cum aestivum L., Salvia Salvia sp., potato S
olanum tuberosum L., rhubarb Rheum rhabarbarum
L., Japanese radish Raphanus sativus L., soybean Glycine ma
x (L.) MERR., tarragon Artemisia dracunculus L., corn Zea mays L., garlic Allium sativum va
r.sativum L., Pineapple Ananas comosus (L.) MER
R., Peanut Arachis hypogaea L., Sunflower Helia
nthus annuus L., Spinach Spinacia oleracea
L., apple Malus domestica BORKH., Etc., or these homologous plants can be used.

[0017]

[Chemical 3]

The "chalcone" used in the present invention is based on Phenylchromane which is a C ₆ -C ₃ -C ₆ compound in which two benzene rings are linked by three carbons, and its oxidation or reduction product. It is one of the flavonoids that is a general term for compounds containing. Chalcone includes chalcone, dihydrochalcone,
Auron etc. are included. Examples thereof include butein, calsamine, phloretin, and sulfretin, with phloretin being particularly preferred. Moreover, you may use these glycosides and derivatives.

The "phloretin" used in the present invention is a compound shown in the following chemical formula (Chemical formula 4), and a glycoside or derivative thereof may be used. Either a product extracted / purified from a natural product or a product obtained by a synthetic method can be used. Regarding these purification methods and synthetic methods,
There is no particular limitation. Examples of plant extracts containing phloretin include lobster Pieris japonica and apple Malus.
Domestica BORKH., etc., or plants of the same genus can be used.

[0020]

[Chemical 4]

The "benzene derivative" used in the present invention is based on a structure in which various side chains are bound to a benzene ring, and is a general term for compounds including their oxidation or reduction products. The benzene derivative includes a resorcinol derivative, a pyrocatechol derivative and the like, preferably salicylic acid, benzoic acid and para-hydroxybenzoic acid. As the benzene derivative, these glycosides or derivatives may be used.

The "salicylic acid" used in the present invention is a compound shown in the following chemical formula (Chemical formula 5), and its glycoside or derivative may be used. Either a product extracted / purified from a natural product or a product obtained by a synthetic method can be used. Regarding these purification methods and synthetic methods,
There is no particular limitation. Examples of plant extracts containing salicylic acid include Filipendula ulm.
aria Maximowicz, Licorice Glycyrrhiza g
labra L., peanut Arachis hypogaea L., wheat T
riticum aestivum L., Tarragon Artemisia dracunculu
s L., Psyllium Plantago major L., Marigold Cale
ndula officinalis L., willow Salix sp., etc., or plants of the same family can be used.

[0023]

[Chemical 5]

The "benzoic acid" used in the present invention means
The compound shown in the following figure (Chemical Formula 6), and its glycoside or derivative may be used. Products extracted and purified from natural products,
Alternatively, either one obtained by the synthetic method can be used. There is no particular limitation on the purification method and the synthesis method. Examples of the plant extract containing benzoic acid include peony Paeonia lactiflora PALL., Cowberry Vaccinium vitis-idaea var.minus LODD., Peppermint Menthax piperita subsp.nothosubsp.piperit
a, anthrax Styrax benzoin, etc., or plants of the same genus can be used.

[0025]

[Chemical 6]

The "parahydroxybenzoic acid" used in the present invention is a compound shown in the following chemical formula (Chemical formula 7),
You may use the glycoside and derivative. Extracted from natural products
Either a purified product or a product obtained by a synthetic method can be used. There is no particular limitation on the purification method and the synthesis method.

[0027]

[Chemical 7]

Plants containing phenylpropanoids (transcinnamic acid, paracoumaric acid, ferulic acid, etc.), chalcones (floretin, etc.), and benzene derivatives (salicylic acid, benzoic acid, parahydroxybenzoic acid, etc.) used in the present invention. Extract means various parts (flowers,
Spikes, pericarps, fruits, stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants, fruiting bodies, sclerotium, mycelium,
Temporary roots, reproductive branches, spermatozoa, raw egg machines, etc.) are squeezed as they are or after crushing. Alternatively, it is extracted with a solvent as it is or after pulverization.

As the extraction solvent for the above-mentioned various plant extracts, water, alcohols (for example, lower alcohols such as methanol, anhydrous ethanol, ethanol, etc.), or propylene glycol, 1,3-butylene glycol, glycerin, etc. (Hydric alcohol), ketones such as acetone, esters such as ethyl ether, dioxane, acetonitrile, acetic acid ethyl ester, and organic solvents such as xylene, benzene, chloroform, etc., alone or in any combination of two or more kinds. Alternatively, the solvent extracts may be used in combination.

The production method is not particularly limited, but it is usually within the range of the boiling point of the solvent at room temperature and atmospheric pressure, and after extraction, filtration or ion exchange resin is used for adsorption / adsorption.
It may be decolorized and purified to form a solution, paste, gel or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added within a range that does not affect the effect, and as a purification treatment means such as deodorization and decolorization. It suffices to use an activated carbon column or the like, and any ordinary means generally applied depending on the extraction substance may be arbitrarily selected.

Further, phenylpropanoids (transcinnamic acid, paracoumaric acid, ferulic acid, etc.), chalcones (floretin, etc.), benzene derivatives (salicylic acid, benzoic acid, etc.)
Parahydroxybenzoic acid and the like) may be adjusted by optionally drying, concentrating or diluting it according to the Maillard reaction inhibitor to which it is applied, and the dosage form / form of the external preparation for skin or food and drink.

The phenylpropanoids (transcinnamic acid, paracoumaric acid, ferulic acid, etc.), chalcones (floretin, etc.), and benzene derivatives (salicylic acid, benzoic acid, parahydroxybenzoic acid, etc.) of the present invention can be used directly as Maillard reaction inhibitors. In addition to the available, it can be further contained in a cosmetic composition or a food or drink, but the content thereof is not particularly specified, but a Maillard reaction inhibitor, a type of skin external preparation or an antiaging food or drink, the quality, Although it varies slightly depending on the expected degree of action, it is usually 0.0001 mass% or more (hereinafter, represented by%), preferably 0.001 to 50.0% in terms of solid content in the total amount of the preparation. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so as to have the same concentration.

The Maillard reaction inhibitor of the present invention, and the external preparation for skin or food and drink, in addition to the above-mentioned essential components, may optionally be added within the range not impairing the effects of the present invention. The agents can be arbitrarily selected and used in combination, and the content in the preparation is not particularly limited, but is usually 0.0001 to 50%.

(1) Various oils and fats Avocado oil, almond oil, fennel oil, sesame oil,
Olive oil, orange oil, orange lafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, Persic oil, Castor oil, Cottonseed oil, Peanut oil, Turtle oil, Mink oil, Egg yolk oil, Palm oil, Palm kernel oil, Owl, Palm oil, Beef tallow, Lard, Squalene,
Squalane, pristane or hydrogenated products of these oils (hardened oil, etc.), etc.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcrystalline wax and the like.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(5) Alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(6) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) with alkylene (C2-C4) oxide such as ethylene oxide added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylates, polyalkylene oxides such as polyethylene oxide and polypropylene oxide Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (ether type nonionic Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) , Protein hydrolyzate derivatives,
Polymer surfactant, surfactant containing titanium / silicon,
Fluorocarbon type surfactant) etc.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), other, essential fatty acid (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Alternatively, amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant or animal-based raw materials These are processed (for example, crushed, milled, washed, hydrolyzed, or hydrolyzed by a conventional method according to the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are selected and combined), and various materials are selected. You can select it and use it.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, the processing to be performed later, and the like. Usually, water, methanol, ethanol, propyl alcohol, isopropyl is used. Alcohol, lower alcohol such as butanol, isobutanol or hydrous lower alcohol, polyhydric alcohol such as propylene glycol, 1,3-butylene glycol, glycerin or hydrous polyhydric alcohol, various organic solvents such as acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more of them. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixed solution with water, or Exploited extract may be used.

Additives derived from plant or animal raw materials are
When used as a systemic or topical external preparation, cosmetics, including protection of skin and hair, moisturizing, improvement of touch and texture,
Giving flexibility, reducing irritation, relieving stress caused by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing rough skin and improving it, hair growth, hair growth, hair loss prevention, gloss , Cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
The effects of antiseptic and buffer can be expected.

In addition, in foods and drinks, healthy and cosmetic effects such as nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging) and the like, improvement of taste, imparting of color tone, aroma and luster, stabilization, It can be used for the purpose of thickening and preserving. In addition to this, expect various various cosmetic and pharmaceutical effects of each raw material known so far, and aim to enhance the desired effect by combining these.
Alternatively, the product can be expected to have a multi-functional effect.

As a concrete plant (crude drug) used as a raw material,
For example, almonds, ai, blue vines
(Seifufuji), Aoki (Aoki), Aogiri or Kenashiaogiri
(Goji paulownia), Aotsutsurafuji (Kibo), Aotenma, Acacia, Red capsicum (Akasoma), Redcurrant `` fruit '', Red clover, Red grapes, Red amber (Logwood), Red algae (Red bud), Red pine or Red madder or Red madder (Akane) (Grassroots), Akagia jiou or jiou (ground yellow),
Agi (A Wei), Aki Larch, Akinire (Resin), Aguay Gua Su, Aguahe (Omi Tenguyashi), Akebei
(Ki-dori), Asa (Asakojin), Malva Morning Glory or Morning Glory
(Dagushi), Hydrangea (hydrangea), Ashitaba (tomorrow leaf), Azuki (red azuki bean), Asunaro, Acerola, Asenyak (Asenyaku), Athira (Sakuyoukanna), anise, abiu, abiulana, canola, abemaki "fruit" ,Avocado,
Ama, Amacha (sweet tea), Amachatsuru, Amadokoro (Tamatake), Amana (Kokoji), Amaranthus (Hiyu, Hagatetow, Himegateto, Senninkoku, Sugimorigateto,
Hosoaogatetou, Aogatetou, Haribiyu, Aozulan, Amaranthus hippocondriacus), Amigasa lily or Fritillaria (shellfish), Aristromelia (Yurizuisen), Arcana (Arcanna), Algarrobo (Cabbage), Artea, Arnica, Alpinia or Katsumadai
(Souzuku), aloe (蘆 薆), aloe vera, angelica, apricot or hon apricot (apricot kernel), ansokkou (benzoin), yellow sapote, igakoukousrina (geijutsu), sardine or chinensis (indian cabbage), rush
(Wicked grass), Japanese knotweed (Kojo root), yew (first place), strawberry,
Fig (flowerless "fruits and leaves"), figs (first), hibiscus (winter aoi), Ichiyakuso (one medicinal herb), ginkgo (ginkgo biloba "seed, leaves"), Itohimehagi (distant), locust bean, Inunazuna (Taylexi) , Inubiyu (Honagainubiyu), rice "seed, seed coat", inondo "seed", Echinochloa japonica, nettle, ylang-ylang, iwatobacco (Iwabaki),
Iwahiba or Iwamatsu (wind roll), common bean, oolong tea, fennel (incense), wheat (Chibana), ukiyagara (Sanryo), Uguisukagura "fruit", Himeyokiou, turmeric (Yukin), duckweed (Ukiwa), Usubasaishin Or Keirin saishin or Sengoku saishin (spicy), mussels mallow, mung bean mallow, medusa orchid, nemophilus (summer hay), udo or shishido (invigoration, independence, indonesia), unyadegat (unkalia, cat's claw),
Uba Tea, Ume (Ume "seed, fruit pulp"), Vladimir Ogashira, Argentine (Rawberry), Unshu Mikan (Chenhide), Umboku, Estragon, Ezo-kogi (Ezo Goka), Ezo Suzuran, Echinashi (Hosobamurasakibareniku, Echinashi), Enishi Mushrooms), Ebisugusa or Cassia tora (Keiko), El Campre, Elderberry "fruit",
Elemi, Eryngii or Pre-Lotus erynge, Enju (Sophorae, Sophorae rice), Pea, Ougi or Kibanana
(Yellow radish), Naruco lily or Kagi Kurumabanaruko Yuri (Yellow), Ohihisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Houken, Ookarasuri (Calocon),
Plantain (Civil engineering incense), Giant tsuboji (Self-defense), Plantain
(Carmaco, Carophyllum), Milk thistle (Yuzhou Leopard, Bald Ear), Toucan Hazel (Haruko), Toucan Cactus, Obana Ochera or Ochera (White Sprout), Obana Sarsberg (Banaba), Ooba Yashaboshi "Fruit", "Fruit" Grains), Oomiacatetsu, Omihawthorn or Hawthorn
(Yamashiko), Omiyashi, Barley (barley), Oka, Okazeri (Heiwako), Okra "fruit", Oguruma (overturning), Oklurihigotai (Banzhou Leopard, Indigo Spin), Panax ginseng or Panax ginseng (carrot) , Hypericum perforatum or Hypericum perforatum or Hypericum perforatum (younger brother cut grass), Odorikosou (intermittent), Onami (blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninogagara
(Tianma), Oniyuri or Sasayuri or Hakatayuri (yuri),
Onoelan, Ononis, halibut, Ominaeshi
(Soy sauce), Oyuco, Dutch mustard (cresson), Dutch jelly, Dutch millet, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, peel",
Kaikaizou (ripe ground yellow), cacao "fruit, peel, seed", oyster (persimmon "leaf"), oyster vine (fishing hook), oyster or citrus root (rensenzo), oyster, hydrangea, cassia, casino ki ( (Fruit `` fruit ''), banyan tree (pepper), oak (camellia tree, camellia leaf), cascarilla, cascara sagrada, gypsophila, kasenso, cypress (Kinshato), kaniwa, carnation, valerian root, hippo,
Birch or weeping birch (white birch), gerbera, pumpkin, kapok cypress `` seed '', kahokusansho (shusho),
Cattail, chamomile or Roman chamomile, chamomile
(Grass), camu camu (duck), color, larva, mantle or crow cucumber (sea melon), crow bischak (half summer), oats, guarana "seed", callahoo
(Koboku), Karaya, Gallu, Karin (Cucurbita), Garcinia, Kawamidori, Kawara Psycho (Koryosai, White-floured grass), Kawajisha, Kawaratake, Kawara-nadeshiko (stone bamboo) or Ezokawaranadeshiko (barley, tannin), Kawaraninjin (Kawaraninjin) (Blue ginger),
Kawamoyogi (Chinese cabbage), Kansui (Asaito), Kanzo
(Licorice), cantara, candelilla, canto, canna, canlan, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, nawairo strawberry, maple strawberry,
European raspberries), kiwi "fruits, leaves", cichlids (melon roots), kyokyo (bellflowers, bellflowers), chrysanthemums (chrysanthemums,
Cicada daisies, Astragalus vulgaris, Amaranthaceae, Catalpa (Azusa), Rumex (Yotei), Kizitsu (Apricot), Kizuta, Kidachiaroe, Kidachiha, Kina, Kinaoki (Shinkona, Akakinanoki), Quinua (quinoa), Kakiha (yellow oak). Kimame, Gymnema sylvestre, Kimenkak, cabbage, cabbage "immature fruit", caraway, cucumber, goryu (Nishikawayanagi, Teyanagi), Kiraja saponaria, Kiraya, Kiranso (Kenshi Kobayashi), Kumquat "fruit", Kinkiju, Ginsekai, Kimbusen, betel,
Kinmizuhiki (Sensakurusu), Kinran, Ginran, Kinryohen, Guapaba Vermelha, Guava "Fruits", Guayule, Quercus Infectria (Gall), Kukui Nuts, Kugenumaran, Cuco (Glitters, Lances of the Barrels) Black-headed whale (Tenmon winter), kudzu
(Kakkon), camphor tree, gooseberry `` fruit '', carrot (yellow flower), kutiti river, gardenia (yamashiko), kunugi (brassica sol), cupua, cubebaba, kumazasa, tsuchidura (horse whiskers), clara (bittersweet) ), Cranberry “fruit”, chestnut “seed, fruit, astringent skin”, curculigo latifolia “fruit”, grapefruit “fruit / leaves”, buckthorn, black ganemochi (necessity of rescue), turtle beetle or black beetle or hikikoshiki (prolonged life grass), clove.
(Cloves, cloves), Gumbai nazuna (Sekimei, Sekimeishi), Keigai (Mature beetle, Magewort), Keitou (crown flower, corolla), geckavidin, bay (ken laurel), kenashi sartoriibara (earthen 苓苓, mountain return genus), gentiana, genchiana. (Old bird), Kemponashi (Kyugushi), Koukisekekoku, Citrus unshiu (Koji, Tachibana, Ovenimikan, Fukuromikan, Sagamikouji, Ponkan, Santara)
(Tachibana skin)), Kousimbara (Monthly flower), Kousui mint, Kozo `` fruit '', Kocha (black tea), Kouhone (river bone), Kouhon (Straw book, Karamoto book), Kouryan, Kori Ryokyo
(Kara Ginger), cilantro “fruit”, Kouren (Kuroren),
Scutellaria (yellow gon), cowberry (over Tachibana), coconut `` fruit '', goshuyu (gojutsu), gosho strawberry (covered bonito), pepper (pepper), cosmos, copaiba balsam, coffee `` seed, leaf '', kobushi or magnolia ( Spicy), burdock (burdock root, burdock root), Kobotsuduru, sesame seeds (sesame), sesame nohagusa (genus), Gomishi (seaweed witch) or vine vine or pine wilt or wheat (wheat), rice or rice bran `` red bran, white bran '', Rice oil, cola acluminata "seed", cola
Bella "seed", colony lya, fenugreek "fruit", Colombo, Conzurango, kelp, konjac, comfrey
(Final herb), sisal (sisal asa), saihairan, sakaneran (ezosakaneran), saxima button vine or cinna button vine or sinensenso (weapon), cherry tree
(Oshima cherry, Yamazakura, Oyama cherry, Ed Higashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "leaf, flower, fruit, bark (cherry bark)", cherry, pomegranate, sasan, sasanbagin , Sageomodaka (Sawaki), sweet potato, sugar cane, sugar beet, sanpeitojutsu (sour citrus fruit), saffron (bancoflower, west safflower), sapodilla, sapotea mario, pomelo "fruit", sabonsou, salmonberry "fruit", salinach
(Rima), Saranshito (sand indigo stab), Salvia (sage),
Pleurotus cornucopiae (mountain bell pepper), gurney (mountain walnut), Sankaku cactus, Sangre degrad (croton), Sankuyouso, Sanshichin ginseng (37 ginseng), Sanshuyu (Yamatake mushroom), Sansho (Japanese pepper), Sandscon (yamazu) Root), shea
(Karite), Cyanoki “fruit”, Shiitake mushroom (Shiitake), Zion
(Shion), winged bean, digitalis, shikunshi (Kimiko),
Perilla or Aojiso or Chimenjizo or Catamejizo
(Shiso leaf, Shiso), rosewood, linden, honoki,
Chinese Forsythia (Forsythia), Shimeji (Hinjimeji, Shakashimeji, Hatake Shimeji, Oshiroijimeji, Beech Shimeji, Honjimeshi, Shiratamogitake), Shimokuren (Spicion), Shimotsukisou, Potato, Peony (peony), Shajin
(Sasam), Jasmine (Matsurika), Janohige (Mugimon winter), Jurassic cowpea, Gypsophila paniculata, Shukshamitsu (Sanden, Crushed sand), Juzdama, Shiro "fruit", Shunran, Scotch palm, Ginger (ginger) ,
Zhouzan Hydrangea (Tsuneyama), Shobu (iris, iris root),
Shozuku "fruit", white oak "seed", silane (butterfly), white swan "seed", white clover (clover), white azuki bean (chicken bone grass), white banyan iris (smell iris), white clover "flower", white lupine, lupine,
Shirominanten (Nami Tenmi), Cinchona Succibula, Jinchoge (Mizuka, Mizukaka, Shichobana), Cinnamon, Cinnamomum cassia (cinnamon skin), Watermelon (watermelon), Honeysuckle
(Gold and silver flower, Shinobi winter), sorrel (acidic), swim berry “fruit”, star apple, stevia, strawberry “fruit”, Suzuko (Sir Xu), horsetail (question), purslane.
(Horse toothpaste, horse toothpaste), plum "fruit", surgaran
(Oran), Pinus sylvestris "cone", Larch arbutus, Ileus vulgaris, Walnut, Hawthorn vulgaris, Vaccinium vulgaris, Dandelion, Horse chestnut (Marronnier), Pear "fruit", Plum vulgaris, Elderflower (Elder), Horsetail
(Juniper, Morimatsu), Achillea millefolium (Milfoil), Rose, Astragalus vulgaris, Mistletoe, Peppermint or Peppermint vulgare, Pleurotus radiscens, Sekisho (Ishikon), Ginkgo
(Sakura Sekkoku, Kouki Sekkoku, Oobanashi Sekkoku, Okinawa Sekkoku, Hong Sekkoku, Kocho Sekokoku, Shikaku Sekkoku, Kibanano Sekokoku) (Dendrobium, Ishibana), Cedron (Boushuubokku), Zeniaoi,
Hiroha Senega, Senega, Celery, Celery, Senkyu (River Kyu), Senshinren (Shinren), Sendan, Sennin Cactus, Senna "Fruits, Leaves", Senninsou (Taiso),
Senburi (this drug), Senboku, Souka (grass fruit), Elephants, soybean rootweed, buckwheat "seed seed", some potatoes, broad bean, rhubarb (daikon), radish, soybean, daidai (orange peel, currant fruit), takasago rorihigotai (south indigo) (Stab), Takasaburo (Lotus lotus), Takatodai (Ojaku), Takawarabi
(Inui), dark sweet cherry "fruit", hollyhock, pearl oyster (thyme, Hyorika), tachidokoro
(Haikai), Tachiyanagi, Tamarind "seed", onion, tamshiba (spicy), Taranoki "fruit, leaf, root bark", Tarayou (Obayu winter blue, single-leaf tea, chincho tea, dacha tea), dahlia
(Tenjiku Button), Tarwi, Tankirimame, Tanchiuchiwa, Tanjin (Ginseng), Dandelion (Ganko Hide) or Shirobana Dandelion or Moco Dandelion, Danmal, Cherry "fruit", Chigaya "fruit, root, sprout", Chixetsu ginseng (Bamboo ginseng) , Chicory, chanka piedra (traditional citrus), tulip, choconostay, artichoke (artichoke), ginseng (large yellow), ginseng (garden), ginseng (spiny leaves), choreimaitake (boiled boar), chologi. , Tsukisou, Tsukushimakaneran, Tsukuritake (mushroom), Tsuchiakebi, camellia, Centella asiatica, Clover (lacquer grass), Tsuyukusa (duckweed grass), Tsuzuki Azuki (red adzuki bean), Tsurutsuchia vine, Tsukudami (Japanese sardine), Apricot (Apricot), Tsuruna, Tsuna (Yoshiba ginseng),
Glycine soja, Tsuwabuki, Deiko, Walnut, Duberry "Fruit", Amaranthus, Tencha (green tea), Tendaiyaku (crow), Pepper (winter gourd), Pine vine, Capsicum (Pancho), Pepper (attributable), Pimples (spotted) Marigold), Gleditsia sinensis, Touna Bena (river cutting), corn or corn hair (nanban hair), squirrel mochi (sadako), gentian or gentian (dragon gall), horsetail (tree bandit), dokudami (ten drug), turmeric (conger) Roots), Toshishi or Mamedaoshi or Nenshikazura, Eucommia (Dunaka "bark, leaves, roots"), Ash (Hata peel), tomatoes, tragacanth, Triacanthus "seed", Eustoma grandiflorum, Tormentilla, Dronoki, Torohoaoi, Tonro beans, Nigeria berry "Fruit", Chinese yam or yam (mountain pot),
Nagiikada (Butcher Bloom), Naginata Koju,
Nazuna, rapeseed, peanut or mane (sword bean), natsumikan, jujube (Oju), Naniwaibara (Kinsakurako), navena
(Interruption), nameko, peanut (peanut), nanten (southern nut), nanbankaramushi (chima), iooi violet, nigaki (sorrow), nigga wormwood (bitterness), nutmeg, kei or nikkei or ceylon nikkei or yab nikkei ( Cinnamon) or Keishi (Keishi), Nyoko-duck, Chinese chive (Nishi), elderberry
(Grafting tree `` fruit, flower, stem, leaf ''), garlic (large garlic), nullde (quintet), leek, alveolum or nebu or nebi or nemlinoki or digobana (enjoyment), thistle (daikon), noira (no fruit), Nostoc vine (Ryohaku), Nogate, Yarrow, Nodake (Phuket), Novara, Nomomo, Pineapple "fruit", Hibiscus (Bussouge, Fuurin Bussouge, Roselle), Hyelindo, Hachiwa, Pau
Doce, Hakamaurabosi (Bone fracture), Hakukayutomu, Chinese cabbage, Chinese cabbage (Ringworm skin), Hakuruberry "fruit", Hakobe (Historical), Hazel (Haruko), Hasiridokoro
(Roth root), basil, lotus (lotus, lotus meat, lotus root), parsley
(Netherlands jelly), hadakamugi, batata, bee weed, or bamboo shoots (boiled bamboo), patchouli, mint (light load, light load leaf), hassho beans, pearl barley (Yokuinin), hanasuge (knowledge mother), banana, hanahakka, hanabishi (shitsuri, shitsuri) , Vanilla vins, papayas, yellow squirrels (mouse koji), pahalobobo, hub "whole grass, stems, leaves", paprika, stilts,
Hamago or Mitsuba Hamago (vine vine), Hamasuge (Kafuzi), Hamabishi (Shitsuriko), Hamanasu (maikai flower), Hamaboufu (hama windbreak), Hamamelis, palm, rose (rose), balata, balata, aratake mushroom,
White-bellied agaric, Usukimorinokasa), Haran, Pariurus (Rhododendron japonicum), Parietaria, Harkanran, Balsamina (Tsurureishi, Nigauri), Harunire
(Insect skin, Elm skin, Insect leaf), Barbasco, Harlindo, Handaikai (Katsu Omi), Panoki, Hyogi (Hikari), Pea nuts, Carrots
(Gypsum, Liu Singh), Higulmadaria, Higotai, Hishi
(Hishimi), pistachio, beet, tsutsumi (Ishidashi), hibiscus edulis, daisies (daisies), Hinako no Kozuchi
(Cow knee), Hydrangea cypress, cypress, hiba, castor, sunflower, bell pepper, Himeuzu (Aoi), himemagama (garlic), Himematsutake (Kawariharatake, Hiromatsutake), Himemuyoran, Pimenta "fruits", juniper, Japanese juniper, Japanese juniper "Fruit", chickpeas, lentils, biloba mallow,
Broad-brushed balsam (bald oak), loquat "fruits, leaves, stems", areca (daisy skin, calyx), puerh tea, futokazura
(South rattan), butterbur, butterbur dandelion (submarine winter flower, subterranean winter leaf), wisteria kama (Orchid grass), wisteria beans (flat bean), wisteria wisteria (chocolate, seeds, leaves), grape "fruit, fruit skin, seeds, leaves", beech, fuyu mucinsk Bamboo shoots (caterpillar), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, Black currant "fruit", Blackberry,
Branjeen, Plum "fruits", Fluceraria, Blueberries (Hemaceae), Prune, Floral Blanca, Blonde Psyllium, Bungou (mung bean), Hazelnuts, Loofah, Hetukaran, Safflowers (Hanaken), Henneken, Belladonna, Berries "fruits", Persear , Peruvian Berg, Pereschia grandifolia, red quince or duckweed (Keiten), Boysenberry "fruit",
Houki, Elderweed, Nendoza, or Hahakiki Kochia (ground silk), Hosairan, Housenka (Housen, Acute child, Bone grass), Pouteria sapota, Pouteria rukuma, Honoki, Bowhuu (windbreak), Spinach, Hozuki (Torone root) ), Japanese holly (Japanese magnolia, magnolia), bokeh (wood melon), Hosoba Abragiku (Bitter Yoku), Hosoba Ogura, Hosobanaokera (Sokyu), Hosobanokirinso (Keiten Sanshichi), Hosobabarengiku, Bodaiju (Bodhi tree), button Peony "Flowers, leaves,
Stem, bark "), button pie (peony skin), hop, jojoba, bourgei (Ruricha), Bordeaux, white berry" fruit ", Hongonik (Meat Juyo, Daiei), Hongsekoku (Sekiseki Suzu, Suzuyama Ishihasu) , Maizuru Tennan Show (Tiannansei), Maitake (Maitake), Maou (Mako), Maca, Macadamia nuts, Margaret (Mokshungiku), Makuri (Seagrass), Magwa (Mulberry bark "bark, leaf"), Magnolia・ Sprengheri, Masarunzuba, Masalanzuuba de Ceara, Masheira de Boi, Mashua (Tamanouzenhallen, Kyukonkinrenka), Matatabi (Matsukasa), Matsukasa, pine "leaf, bark, root", Matta Orho, Matsuhodo (boiled peony), Matico (Cordon sillo), Mayoram (Hanajaca), Marvanojazin (Ginseng), Mulberry "fruit", quince, Malein (Bilroadmou) Zuica), mango, mangosteen, mansagna (Andes chamomile), manshugurumi, mandarin "fruit",
Ganoderma lucidum (Ganoderma lucidum), Pheasant (Gourmet `` Fruit ''), Mishima Psycho (Saiko), Water plantain or Water morning glory (Rhinoglossus),
Mizokukushi (Half-sided lotus), Misohagi (Senkyaku), Michiyanagi or Niwayanagi (Henji), Mitsugashiwa, Mitsuba, Midori Zapote, Midorihakka, Mimosa, Myoga, Miracle Fruit "fruits", Myrrh, Myrobalan, Mugiwaragiku, Mukuge , Mukunoki, Mukuroji (prolonged skin), Munya, purple (purple root), purple syrup or purple syrup
(Purple), purple corn, purple fuji (Kunmei chicken blood wisteria), megakansa opuntica, swordfish (beneficial herbs), barley, melaleuca, melissa, meliloth,
Melon "fruit", Mokoyomogi, Moso bamboo, Mokugirin, Moje (pepper), Mochinoki, Mokko (tree incense), Japanese maple, Peach (peaches "leaves, seeds, flowers, fruits"), coconut, morello cherry "fruit" , Moroheiya
(Burlap), yakawamurasaki yak, yakchi (maschi), cornflower (cornflower), cornflower, yacon, yashabushi (arrow wheel) or Himeyashabushi or Obayashishabushi "fruit, fruit skin, fruit ear", yam willow, yam depot (octagonal metal plate) , Mistletoe (willow parasitism), willow (Kiyanagi, Tachiyanagi, weeping willow, red willow, cat willow, dog cory willow, willow willow, cory willow, unryow willow, willow willow, palm, willow willow, willow willow,
(Tailuku nuyanagi, fox willow, doronoki), willow tree "leaf, stem", porcupine, yam koji (purple gold cattle),
Yab Tobacco (Tsuru, Tenmei), Yamabobo (Shokuryoku), Yamanoki (Yamaharu), Yamamomo (Yangume), Yamamogomi, Eucalyptus, Yukinoshita (Tiger's ear grass), Yucca or Flavifolia, Yuzu `` fruit '', lily, Yellow primrose, mugwort (moth leaf),
Rigan (Thunder maru), lime "fruit", rye, swingle "fruit", raspberry "leaves, fruits", latania (clamellia), rakkyo or shallot (caucasian white), lavender, longan (longan meat), agave lantern (aono agave, fukurin). Agave, green tea, apple "fruit, seeds, leaves, roots", gentian, lubas or Suavesimus (Violet), thistle (Valentillo higotai, Xinjiang indigo head), litchi (lunch, litter branch), lettuce (Chisha), Red currant "fruit", Red pitaya, Lemon "fruit", Lemongrass, Forsythia or Forsythia (Forsythia), Astragalus, Rhizome, Waus palm, Locon (Reed, root), Logan berry "Fruit" ,, rosemary (mannenrou), rosehip (novara), wasabi, cottonweed (Japanese flower), Remokou
(Jiju) and the like.

As the seaweeds, there are seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, aonori (Usubaaonori, Sujiaonori, Hiraaoonori, Bouaonori, Hosoedaonori), Anaaosa (sea algae), Kind: kelp (Macombus, liquorice, Hosomekonbu, Mitsuishikonbu), wakame, hirome, aowakame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitrus ruetokeana), hijiki, hibamata, sea uchiwa, usubaumiu Kirebanoumiuchi, Akabatumiuchi, Konaumiuchiwa, Okuchiuchiwa, Usuyukiuchiwa, Echiukiumiuchiwa], Seaweed [Red algae: Hijirimen, Hakusa, Hirakusa, Onik , Obakusa, Kataobakusa,
Yatabegusa, Yukigiri, Amanita, Tosakanori, Togekirinsai, Amaxakirinsai, Giraffe, Jakushinkirinsai, Tsunomata, Obatatsunomata, Tochaka (Nyakuzuna-no-Tomashita), Ezotsunomatsuta, Togenomata, Hirasakonotoma, Kotobuki, Kotobuki, Kotobushi
[Yaleus Banori, Kagious Banori, Suzius Banori, Haius Banori, Akamomijinori] and the like.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Anemone: Quanonimo, Volvox: Ohigewawari, Volbox, Palmera, Yotsumeu, Genus Aomizu: Hizaori, Ao midori, Genus Tsurugimido, Genus Himidoro: Hibimidoro, Genus Aosa: Anaaosa, Amiosa, Nagaaosa, Kawanori: Kawanori,
Fruicula genus, Shiogusa genus: Oenothera genus, Asamidoriushigusa, Kawashiogusa, Marimo, Baronia genus: Tamagobalonia, Tamabaronia, Magatagum genus: Magata, Iwachia genus: Fusaiwaduta, Black squirrel, Mildewer, Black millet, Nematoda, Hagemonia, Nematoda. Sakibutimir, Nagamir, Hiramiru, and Kasanori:
Casanori, genus genus: Futozuzumo, Tamazuzumo,
(Mizujuzumo, Mikadzuki genus, Colecaete genus, Tsudumimo genus, Kikkokusa genus: Kikkokusa, Astragalus genus: Hitogusa, Hirohanohitohegusa, Usutoegusa, Motukihitoe, Sayamidoro, etc.

Cyanobacteria (genus Suizenjinori: genus Suizenjinori, genus Algae, genus Nostoc: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aiacacio), etc.).

Brown algae (Pyraera: Pyraela, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Prickly squirrel, Ulaboshihaha, Symphalida: Symphologus, Cyperus genus: Cyperus cypress, Konaumi uchiwa, Akabayumi uchiwa, Namikura genus: Prunus chinensis, Somexaceae genus: Somenaceae
Pinus genus: Matsumo, Nagamatsu genus: Nagamatsu moth, Okinawa mozuku genus: Okinawa mozuku, Niceft mozuku genus: Physcomit genus, Physmozuku genus: Physcomitum genus: Genus mosquito: Genus mosquito: Genus moss, Genus moss Isige, Iroro, Ichimegasa: Ichimegasa, Calligraphy: Calli, Umibosu: Umibosu, Urushigusa: Urushigusa,
Black cypress, Tobacco bug, Genus: Haemorium, Haberdoki: Haberodoki, Havanori: Havanori, Habernori: Hazelnut, Common genus: Common butterbur, Ezoburo genus: Nematode: Nephila, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Pleurotus vulgaris Genus Kagomenori: genus Kagomenori, genus Muralis: murachidori, genus Phalaenopsis: shark
Sardine: Sardine, Asclepias: Asclepias, Kayamonori: Kayamonori, Fennel genus: Fennel, Tsurumo: Tsurumo, Anata: Squirrel, Susume: Aedes albopictus, Missus konjac, Miscanthus, Aedes radisculent, konjac beetle, konjac beetle, scutella conserved , Onikonbu, Goheikonbu, Nagakombu, Pea kombi, Otojijimokubu, Tororokonbu genus: Tororocombu, Antocume: Antokume, Kajime: Kajime, Tsuruarame, Kurume, Chrysanthemum genus: Chrysanthemum genus: Necrochamus genus, Black konjac genus, Black locust, Black civet, : Catfish,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

Red algae (genus: Kensuke Nori, Funori Nousuke, genus Noriophyra: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Pteridophytes: Pleurotus, Pleurotus: Pleurotus: Rumex, Ryumonsou: Ryumonsou, Hera Ryumon, Nymphalaceae: Nisekarekigusa: Okitsubara genus: Psyllium syllabus: Acacia
Naminohana, Coral Spodoptera: Rattlefish, Shiogusagoromo: Shiogusagoromo, Ivanoka genus: Etsukiiwanokawa, Kainokawa: Kainokawa, Kanitonote: Kaninote, Corydalis, Dendrobium, Scutellaria, Dioscorea, Rhizophorus, Scutellaria, Saccharomyces , Tambanori, slippery,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Amanita genus: Nectaria vulgaris, Fushiklenori genus: Fushiklenori, Namibia genus: Pleurotus cornucopiae, Cyprinidae: Pleurotus genus, Periwinkle genus: Periwinkle, Prunus genus: Pleurotus genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhizopus, Fujimatsumo: Fujimatsumo, Sawtooth genus: Toothbrush Mushrooms, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Algae (genus Chara, genus Citra,
The genus Rhizopus: Rhizophyllum, the genus Lichnotamnus, the genus Flamus: Himaflamus, Chaboflamus, Tripera, etc.), the yellow algae (Genus Hikarimo: Hikarimo, etc.), etc.

Materials derived from animal-derived raw materials include poultry extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposition products thereof, beef or pig. Brain tissue extract, hydrolyzed collagen hydrolyzate (acid, alkali, enzyme, etc.) of cattle, pigs or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin of cattle or pigs or elastin hydrolyzate (acid , Alkali, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or bovine blood cell protein degradation product (globin peptide), to cow or pig Degradation products of hemoglobin (hemin, hematin, heme, protoheme, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

As the material derived from plant or animal raw materials, any site derived from a gene recombinant or a cell fusion,
Cells, tissues, organs, metabolites, etc. can also be used.
Furthermore, for example, an undifferentiated cell group, a cell group in the process of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can be used.

(14) Marine components Seawater such as deep water, for example, seawater salt, dried seawater, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic Ocean or the Pacific Ocean, sea mud Or mud (fango), for example, sea mud or mud of various places such as Italian fango, German fango, Eifelfango, and Freiburgfango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitoku stone, etc.

(15) Microorganism culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, Fermented rice extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermented product of raw milk or skim milk powder, fermented product of lactic acid bacterium of legumes, lactic acid bacterium of coconut plant Fermented material, etc.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, Gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) Ultraviolet absorbing / blocking agent Benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), para-aminobenzoic acid derivative ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline Derivative, pyrimidine derivative,
Dioxane derivative, camphor derivative, furan derivative,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escarol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening agent Para-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative,
Nucleic acid derivative, allantoin derivative, nicotinic acid derivative,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract. , Ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside etc.), hydroquinone or its derivative (hydroquinone benzyl ether etc.), kojic acid or its derivative, vitamin E or Derivatives thereof, N-acetyltyrosine or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou,
Clara, mugwort, honeysuckle, yellowfin, duckweed, matsuhod, pearl barley, duckweed, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankaishi, hamarisu, yamagwa, extended life grass, bellflower, horsetail, succulent, yellow-dried, hemp dry, hemp. Senkyu, dokkatsu, psycho, bow hu, hama boufu, sardine, peony skin, peony, genosho, kakkon, licorice, quintuplet, aloe, shouma, safflower, green tea, black tea, assen drug) etc.

(21) Melanin dye reducing / decomposing substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether)
etc.

(22) Turnover promoting action / cell activating substance Hydroquinone, lactic acid bacterium extract, placenta extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, dragonfly, horsetail, gentian, burdock,
Sikon, carrot, hamamelis, hop, yokinin,
Odori Koso, Assemblies, Touki, Daffodil, Amacha, Hypericum, Cucumber, Prickly Pear,
Rosemary, parsley) etc.

(23) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

(25) Antioxidant Vitamin C or salt thereof, stearic acid ester, vitamin E or derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamorin, Gossypol, Propolis etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame cultured cells, armature,
Hypericum perforatum, Hamamelis, Clove, Melissa, Trillium birch, Salvia, Rosemary, South Tenmi, Ages, Ginkgo, green tea) etc.

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, chamazulen, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, shikon extract, agets extract, propolis and the like.

(28) Antibacterial / bactericidal / disinfectant Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercury chrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, porridge powder, iodine compound,
Iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarbane, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant Agents (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (odor Trimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jermal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, kujin, propolis, etc. .

(29) Humectant Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidonecarboxylic acid or its Salt, sodium lactate, mini-sasaniki extract, Bacillus natto metabolite, natto extract, loofah water, birch (white birch) or sap of red pine

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (salmon, hypericum, clara, mulberry leaf, cinnamon, ginger ginger, comfrey, salvia, elderberry, bodige, button pipi), seaweed extract and the like.

(31) Hair agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(32) Antiandrogen agent Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(33) Peripheral blood flow promoter Vitamin E or a derivative thereof, cucumber extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Capsicum tincture, nonyl acid vanilamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolism activator Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

(36) Antiseborrheic agent pyridoxine or its derivative, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

(38) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate peroxide, sodium bromate, potassium bromate, pyroline peroxide Sodium phosphate, sodium peroxyorthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract, etc.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(40) Hair swelling agent Ethanolamine, urea, guanidine, etc.

(41) Dyeing agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-Nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

(42) Fragrances Natural animal fragrances such as musk, civet, catrium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, karaway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black character essential oil, cinnamon essential oil, ginnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mint essential oil, large scented essential oil, tuberose essential oil, clove essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Sandalwood essential oil, petitgrain essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, Peruvian balsam essential oil, boad rose essential oil, scented essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary Vegetable oils such as essential oils and Japanese peppermint oil, and other synthetic flavors.

(43) Dye / Colorant Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(44) Sweetener Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monerin, licorice extract and the like.

(45) Nutrient enhancer Calcined shellfish calcium, cyanocholamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.

(46) Dairy products Milk, cheese, fresh cream, butter, margarine, powdered milk, whey, condensed milk, etc.

(44) Other hormones, sequestering agents, pH adjusting agents, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetic agents
Vegetable protein and its degradation products, animal / vegetable polysaccharides and its degradation products, animal / vegetable glycoprotein and its degradation products, blood flow promoters, anti-inflammatory / anti-inflammatory / anti-allergic agents, cell activating agents, Keratolytic agents, wound healing agents, foam boosters, thickeners, oral agents, deodorants / deodorants, bitters, seasonings, enzymes, etc. An additive or synergistic Maillard reaction inhibitory action can be expected depending on the combined use with a component having a known Maillard reaction inhibitor.

Further, the dosage form of the Maillard reaction inhibitor, the external preparation for skin or the food and drink of the present invention is arbitrary, and includes capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, creams,
It can be mixed and used in the form of an ointment, a sheet or the like.

Specifically, for example, internal / external medicinal preparations, lotions, emulsions, creams, ointments, lotions, oils, basic cosmetics such as packs, facial cleansers, skin cleansers, depilatory agents, depilatory agents. Makeup cosmetics such as, after shave lotion, pre-shave lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail enamel, nail enamel, nail enamel remover, shampoo, Rinse, hair treatment, pre-hair treatment, hair styling agent, perm agent, hair nick, hair dye, hair growth / hair nourishing hair cosmetics, bath agent, deodorant, deodorant, poultice,
It can be applied to various products such as plaster, tape, sheet, patch, aerosol, etc., toothpaste, mouthwash, mouthwash, sanitary cotton, wet tissue, etc.
It can also be used for general food and drink.

Regarding the method of adding the Maillard reaction inhibitor of the present invention, and further to the skin external preparation or the food or drink, it may be added in advance or during the production, and the workability may be considered as appropriate. Just select it.

[0096]

EXAMPLES Hereinafter, test examples and prescription examples will be described, but the present invention is not limited thereto.

(Test 1) Pentosidine
Measurement of production inhibitory effect The Maillard reaction (browning reaction) is a non-enzymatic protein saccharification reaction. This is a bond between a reducing sugar and an amino acid or protein that controls various physiological functions in the living body, and forms a yellowish brown substance. The initial reaction product of the Maillard reaction is a protein-sugar conjugate called an Amadori compound. Further, this reaction forms a yellowish green substance having fluorescence through dehydration and polymerization. This is called advanced saccharified substance. It is known that this series of reactions impairs the function of the protein and further forms intramolecular and intermolecular crosslinks of the protein. This advanced saccharification product (the final product of Maillard reaction)
The inhibitory effect was evaluated by comparing the production inhibition rate (%) of pentosidine, which is one of the above.

“Test Method and Evaluation Method” a. Samples Transphenyl cinnamic acid, paracoumaric acid, ferulic acid as chalcone, phloretin as chalcone, salicylic acid, benzoic acid, parahydroxybenzoic acid as benzene derivative of the present invention, and flavonoids (quercetin, kaempferol) and isoflavone (genistin) as comparative samples. ), Tannin (epigallocatechin, tannic acid)
Each was adjusted to 10 mg / mL with dimethyl sulfoxide and subjected to the test. Dimethyl sulfoxide was prepared as a positive control, and 1 mM and 10 mM aminoguanidine were prepared as comparative controls under the same conditions and used in the test. b. Measurement of pentosidine production inhibitory effect 500 mM Ribose, 500 mM Lysine, 500 mM A in 25 μL of sample solution
Add 95 μL each of rginine, 100 mM Na ₂ HPO ₄ (pH7.4) and H ₂ O, and add 6
After incubating on a heat block for 24 hours at 0 ℃, after the reaction was completed, 400 μL of H ₂ O was added to 100 μL of the reaction solution, and pentosidine (pentosidin) was added by high performance liquid chromatography.
e) The amount produced was measured.

<High performance liquid chromatography measurement conditions>
Acetonitrile: TFA: H ₂ O = 3: 0.1: 96.9 was used as the solvent. Flow rate 1 mL / min, column temperature 40 ° C, excitation wavelength 335
The measurement wavelength is 380 nm. Injection amount is 1
Perform with 0 μL. The pentosidine preparation is M
It was adjusted based on Onnie's method and confirmed by various instrument spectral data. Using it, it was confirmed that the peak on the high performance liquid chromatogram was pentosidine.

[0100]

(Test Results) As shown in Table 1, transcinnamic acid, paracoumaric acid, ferulic acid classified as phenylpropanoids of the present invention, phloretin classified as chalcone, and salicylic acid classified as benzene derivative, benzoic acid, It has been confirmed that parahydroxybenzoic acid has a pentosidine production inhibitory activity similar to that of aminoguanidine, and can be used as a Maillard reaction inhibitor.

(Test 2) Safety test (1) Primary skin irritation test Phenylpropanoids of the present invention (transcinnamic acid, paracoumaric acid, ferulic acid), chalcone (phloretin),
A benzene derivative (salicylic acid, benzoic acid, parahydroxybenzoic acid) was prepared in purified water to a concentration of about 0.05%, and the back was shaved Japanese white rabbit (female, 1 group 3
(Apparatus, body weight: around 2.3 kg). Applicable 24, 4
Eight and 72 hours later, evaluation was carried out using erythema and edema as indicators based on the Draize criterion. As a result, no erythema or edema was observed in any of the animals, and it was judged that there was no problem with respect to primary skin irritation.

(Test 3) Safety test (2) Cumulative skin irritation test Phenylpropanoids of the present invention (transcinnamic acid, paracoumaric acid, ferulic acid), chalcone (phloretin),
A benzene derivative (salicylic acid, benzoic acid, parahydroxybenzoic acid) was prepared in purified water to a concentration of about 0.05%, and the back of the Hartley guinea pig was shaved (female, 1 group, 3 animals, weight 320g) Once a day for 5 days on the skin
0.5 mL / animal was applied once. Apply over 2 weeks,
Shaving was done on the last application day of each week. On the day after each application day and the day after the last application day, evaluation was performed using erythema and edema as indexes based on the Draize criterion. The result was that no erythema or edema was observed in any of the animals for 2 weeks.
It was judged that there was no problem with cumulative skin irritation.

(Test 4) Safety test (3) Single dose toxicity test Phenylpropanoids of the present invention (transcinnamic acid, paracoumaric acid, ferulic acid), chalcone (phloretin),
A benzene derivative (salicylic acid, benzoic acid, parahydroxybenzoic acid) was adjusted to 0.05% concentration with purified water, and 16 mL / kg per animal was fasted for 4 hours before the test ddy mouse (male And female, 5 animals per group, 5 weeks old)
Oral administration was carried out and the onset and degree of toxicity were observed over time. As a result, it was confirmed that no abnormality was observed in all mice for 14 days, and the results of autopsy were also normal. Therefore, LD50 is considered to be 2,000 mg / kg or more, and it was confirmed that it is a safe substance.

(Formulation Example) Production of Maillard Reaction Inhibitor, Skin External Agent or Food and Beverage According to the above evaluation results, its formulation example is shown below. Each formulation example was produced by a conventional method in the production of each product. However, only the blending amount is shown. Further, the present invention is not limited to these.

[0106] (Prescription example 1) Emulsion mass%     1. Squalane 5.0     2. Olive oil 5.0     3. Jojoba oil 5.0     4. Cetyl alcohol 1.5     5. Glycerin monostearate 2.0     6. Polyoxyethylene (20) cetyl ether 3.0     7. Polyoxyethylene (20) soorbitan monooleate 2.0     8.1,3-butylene glycol 1.0     9. Glycerin 2.0    10.A: Transcinnamic acid       B: Paracoumaric acid       C: Ferulic acid       D: Phloretin       E: Salicylic acid       F: Benzoic acid       G: Para-hydroxybenzoic acid       * Any one of A to G 0.05    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume proper amount    13. Residue to make purified water 100

[0107] (Prescription example 2) Emulsion mass%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Glyceryl p-aminobenzoate 1.0     4. Ethyl urocanate 1.0     5. Vitamin C phosphate magnesium salt 1.0     6. Cetyl alcohol 1.5     7. Glycerin monostearate 2.0     8. Polyoxyethylene (20) cetyl ether 3.0     9. Polyoxyethylene (20) soorbitan monooleate 2.0    10.1,3-butylene glycol 1.0    11. Glycerin 2.0    12. Transcinnamic acid 0.03    13. Paracoumaric acid 0.03    14. Pork placenta water extract 3.0    15. Preservative (paraoxybenzoate) Suitable amount    16. Residue to make purified water 100

[0108] (Prescription example 3) Cosmetic oil mass%     1. Liquid paraffin 30.0     2. Squalane 20.0     3. Olive oil 20.0     4. Isopropyl palmitate 10.0     5. Ferulic acid 0.03     6. Phloretin 0.03     7. Olive oil 1.0     8. Shea butter 1.0     9. Butylhydroxyanisole 0.1    10. Vitamin E derivative 0.1    11. Preservative (benzalkonium chloride) Suitable amount    12. Perfume (tow water) Appropriate amount    13. Residue to make purified water 100

[0109] (Formulation Example 4) Flexible lotion mass%     1. Glycerin 5.0     2.1,3-butylene glycol 5.0     3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0     4. Ethanol 15.0     5. Salicylic acid 0.01     6. Benzoic acid 0.01     7. Para-hydroxybenzoic acid 0.03     8. Pepper peel or fruit 30% ethanol extract 1.0     9. Kiwi fruit 50% ethanol extract 1.0    10. Antibacterial / antiseptic (lactoferrin solution)    11. Fragrance (Western light water) Suitable amount    12. Residue to make purified water 100

[0110] (Prescription example 5) Astringent lotion mass%     1. Sorbit 2.0     2.POE (20) oleyl alcohol 1.0     3. Ethanol 15.0     5. Assembly 50% 1,3-butylene glycol extract 2.0     6. Yeast 50% 1,3-butylene glycol extract 2.0     7. Soaproot leaves 50% 1,3-butylene glycol extract 2.0     8. Gentian whole plant 50% ethanol extract 1.0     9. Transcinnamic acid 0.01    10. Paracoumaric acid 0.01    11. Ferulic acid 0.03    12. Allantoin 0.2    13. Astringent (zinc sulfocarbonate) 0.2    14. Antibacterial and antiseptic (thiamin lauryl sulfate)    15. Perfume (lavender water) Suitable amount    16. Residue to make purified water 100

[0111] (Prescription example 6) Two-layer type lotion (liquid-liquid type) mass%     1. Squalane 8.0     2. POE sorbitan tetraoleate 0.3     3. Solbit 1.0     4. Ethanol 15.0     5. Red radix rhizome or root bark 50% propylene glycol extract 2.0     6. Purple Root 50% propylene glycol extract 2.0     7. Shiso leaf 50% propylene glycol extract 2.0     8. Phloretin 0.01     9. Salicylic acid 0.01    10. Benzoic acid 0.03    11. Ascorbic acid 0.2    12. Astringent (calamine) 0.1    13. Preservative (phenoxyethanol) Appropriate amount    14. Perfume (lemon water) Suitable amount    15. Residue to make purified water 100

[0112] (Prescription example 7) Carmine lotion (liquid to solid) mass%     1. Glycerin 3.0     2.1,3-butylene glycol 5.0     3. Ethanol 15.0     4. Iron oxide (red iron oxide) 0.2     5. Zinc oxide 0.5     6. Kaolin 2.0     7. Astragalus flower 50% propylene glycol extract 2.0     8. Peony root 50% propylene glycol extract 2.0     9. Mulberry flowers or leaves 50% propylene glycol extract 2.0    10. Chamomile flower 50% propylene glycol extract 2.0    11. Para-hydroxybenzoic acid 0.01    12. Transcinnamic acid 0.01    13. Paracoumaric acid 0.03    14. Camphor 0.2    15. Phenol 0.03    16. Preservative (photosensitive element 201 & 401)    17. Perfume (bodhi tree water) Suitable amount    18. Residue to make purified water 100

[0113] (Prescription example 8) Pack mass%     1. Polyvinyl alcohol 15.0     2. Carboxymethyl cellulose sodium 5.0     3. Propylene glycol 3.0     4. Ethanol 10.0     5. Ferulic acid 0.01     6. Phloretin 0.01     7. Salicylic acid 0.03     8. Tojiji Bud 50% Glycerin Extract 1.0     9. Satsuma mandarin peel 50% glycerin extract 1.0    10. Preservative (paraoxybenzoate) Suitable amount    11. Perfume (Rose water) Suitable amount    12. Residue to make purified water 100

[0114] (Prescription example 9) Peel-off pack mass%     1. Glycerin 5.0     2. Propylene glycol 4.0     3. Polyvinyl alcohol 15.0     4. Ethanol 8.0     5. Polyoxyethylene glycol 1.0     6. Pantothenyl ethyl ether 1.0     7. Benzoic acid 0.01     8. Parahydroxybenzoic acid 0.01     9. Transcinnamic acid 0.03    10. Dutch jelly (parsley) leaf or stem 50% ethanol extract 2.0    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume (cypress leaf water)    13. Residue to make purified water 100

[0115] (Prescription example 10) Cold cream mass%     1. White beeswax 11.0     2. Liquid paraffin 22.0     3. Lanolin 10.0     4. Olive oil 5.0     5. Chamomile oil 5.0     6. Palm oil 5.0     7. Borax 0.5     8. Paracoumaric acid 0.01     9. Ferulic acid 0.01    10. Phloretin 0.03    11. White birch bark extract 2.0      (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    12. Liquid shea fat 1.0    13. Preservative (acrinol) 0.1    14. Perfume (sage water) appropriate amount    15. Residue to make purified water 100

[0116] (Formulation example 11) Emollient cream mass%     1. Stearic acid 2.0     2. Stearyl alcohol 7.0     3. Reduced lanolin 2.0     4. Squalane 5.0     5. Octyldodecanol 6.0     6. Polyoxyethylene cetyl ether (25E.O.) 3.0     7. Lipophilic glyceryl monostearate 2.0     8. Propylene glycol 5.0     9. Salicylic acid 0.01    10. Benzoic acid 0.01    11. Para-hydroxybenzoic acid 0.03    12. Rosemary leaf or flower hot water extract 2.0    13. Preservative (paraben) Suitable amount    14. Perfume (clove water) appropriate amount    15. Residue to make purified water 100

[0117] (Prescription example 12) Face wash cream Mass%     1. Myristic acid 25.0     2. Stearic acid 5.0     3. Beef tallow fatty acid 5.0     4. Propylene glycol 10.0     5. Potassium hydroxide 6.0     6. Coconut oil fatty acid diethanolamide 6.0     7. Almond extract 2.0      (Ethanol: 1,3-butylene glycol = 1: 2 extraction solvent)     8. Transcinnamic acid 0.01     9. Paracoumaric acid 0.01    10. Ferulic acid 0.03    11. Bifidobacterium extract 1.0    12. Dipotassium glycyrrhetinate 1.0    13. Preservative (salicylic acid) 0.1    14. Perfume (sage water) appropriate amount    15. Residue to make purified water 100

[0118] (Prescription example 13) Face-wash cream mass%     1. Stearic acid 10.0     2. Palmitic acid 10.0     3. Myristic acid 12.0     4. Lauric acid 4.0     5. Oleyl alcohol 1.5     6. Lanolin derivative (EO adduct) 1.0     7. Glycerin 18.0     8. Potassium hydroxide 6.0     9.A: Transcinnamic acid       B: Paracoumaric acid       C: Ferulic acid       D: Phloretin       E: Salicylic acid       F: Benzoic acid       G: Para-hydroxybenzoic acid       * Any one of A to G 0.05    10. Royal Jelly Extract 1.0      (Ethanol: 1,3-butylene glycol = 1: 1 extract)    11. Glycyrrhetinic acid 1.0    12. Preservative (salicylic acid) 0.1    13. Perfume (Mugwort water) Suitable amount    14. Purified water 100 residue

[0119] (Prescription example 14) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Himematsutake 70% 1,3-butylene glycol extract 1.0     5. Garlic extract of Production Example 3 1.0     6. Transcinnamic acid 0.01     7. Paracoumaric acid 0.01     8. Ferulic acid 0.03     9. Polyethylene powder 0.5    10.Hydroxypropyl chitosan solution 0.5    11. Amino acids (glycine, glutamine, etc.) 0.5    12. Preservatives (undecylenic acid, phenol) Suitable amount    13. pH adjusting agent    14. Perfume (Lavender water) Suitable amount    15. Residue to make purified water 100

[0120] (Prescription example 15) Sunscreen cosmetics (O / W type) Mass%     1. Oxybenzone 2.0     2. Octyl para methoxycinnamate 5.0     3. Squalane 10.0     4. Vaseline 5.0     5. Stearyl alcohol 3.0     6. Stearic acid 3.0     7. Glyceryl monostearate 2.0     8. Polyethyl acrylate 1.0     9.1,3-butylene glycol 6.0    10. Disodium edetate 0.1    11. Triethanolamine 1.0    12. Titanium dioxide 5.0    13. Phloretin 0.01    14. Salicylic acid 0.01    15. Benzoic acid 0.03    16. Preservative (paraben) Suitable amount    17. Perfume (apple water) Appropriate amount    18. Residue to make purified water 100

[0121] (Prescription example 16) Sunscreen cosmetics (oil type) Mass%     1. Liquid paraffin 70.0     2. Ethyl paraaminobenzoate 1.0     3. Tetrahydroxybenzophenone 1.0     4. Cetyl octanoate 25.0     5. Narco lily 30% 1,3-butylene glycol extract 1.0     6. Roman chamomile flower 10% 1,3-butylene glycol extract 1.0     7. Burdock root 50% 1,3-butylene glycol extract 0.5     8. Parahydroxybenzoic acid 0.01     9. Transcinnamic acid 0.01    10. Paracoumaric acid 0.03    11. Antioxidant (Butyl hydroxytoluene) Suitable amount    12. Fragrance (cornflower water) Suitable amount

[0122] (Prescription example 17) Cream foundation (O / W type) Mass%     1. Stearic acid 4.0     2. Glycerin monostearate 3.0     3. Cetanol 1.5     4.Isopropyl myristate 7.0     5. Liquid paraffin 10.0     6. White beeswax 3.0     7. Triethanolamine 1.5     8. Glycerin 3.0     9. Bentonite 1.0    10.Titanium oxide 8.0    11.2,4-Dihydroxybenzophenone 8.0    12. Kaolin 3.0    13. Talc 3.0    14. Coloring pigment (yellow iron oxide) 1.0    15. Ferulic acid 0.01    16. Phloretin 0.01    17. Salicylic acid 0.03    18. Preservative (phenoxyethanol) Appropriate amount    19. Perfume (Rose water) Suitable amount    20. Residue of purified water 100

[0123] (Prescription example 18) Shampoo mass%     1. Lauryl sulfate triethanolamine 5.0     2. Sodium polyoxyethylene lauryl ether sulfate 12.0     3.1,3-butylene glycol 4.0     4. Lauric acid diethanolamide 2.0     5. Disodium edetate 0.1     6. Apricot 20% 2,3-butylene glycol extract 2.0     7. Benzoic acid 0.01     8. Parahydroxybenzoic acid 0.01     9. Transcinnamic acid 0.03    10. Hydroxypropyl chitosan solution 2.0    11. Mucopolysaccharide solution 1.0    12. Antibacterial / antiseptic (photosensitive element 101)    13. pH adjusting agent    14. Perfume (sandalwood water)    15. Residue to make purified water 100

[0124] (Prescription example 19) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Akebi 50% 1,2-butylene glycol extract 1.0     6. Paracoumaric acid 0.01     7. Ferulic acid 0.01     8. Phloretin 0.03     9. Hydroxyethyl chitosan solution 1.0    10. Trehalose solution 1.0    11. Hydrolyzed silk solution 1.0    12. Antibacterial / antiseptic (benzalkonium chloride)    13. Perfume (Lavender water) Suitable amount    14. Purified water 100 residue

[0125] (Prescription example 20) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Ethylene glycol 3.0     6. Salicylic acid 0.01     7. Benzoic acid 0.01     8. Para-hydroxybenzoic acid 0.03     9. Trehalose solution 1.0    10. Hydrolyzed keratin solution 1.0    11. Antibacterial and antiseptic (benzalkonium chloride)    12. Perfume (Chamomile water) Suitable amount    13. Residue to make purified water 100

[0126] (Formulation example 21) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Transcinnamic acid 0.01     6. Paracoumaric acid 0.01     7. Ferulic acid 0.03     8. Carpronium chloride 0.3     9. Hinokitiol 0.5    10. Keratin decomposition solution 1.0    11. Antibacterial / antiseptic agent (paraben, benzalkonium chloride)    12. Perfume (Rosehip water) Suitable amount    13. Residue to make purified water 100

[0127] (Formulation Example 22) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Trimethylene glycol 5.0     6. Phloretin 0.01     7. Salicylic acid 0.01     8. Benzoic acid 0.03     9. Azulene 1.0    10. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    11. Perfume (jasmine water) Suitable amount    12. Residue to make purified water 100

[0128] (Prescription example 23) Heartnic mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4.A: Transcinnamic acid       B: Paracoumaric acid       C: Ferulic acid       D: Phloretin       E: Salicylic acid       F: Benzoic acid       G: Para-hydroxybenzoic acid       * Any one of A to G 0.05     5. Comfrey leaf or stem 50% ethanol extract 3.0     6. Lettuce leaf 50% ethanol extract 3.0     7. Preservative (phenoxyethanol) 0.1     8. Residue to make purified water 100

[0129] (Prescription example 24) Hair artic mass%     1.l-menthol 0.2     2. Ethanol 32.5     3. Polyoxyethylene hydrogenated castor oil 0.5     4. Propylene glycol 5.0     5. Diphenhydramine hydrochloride 0.3     6. Benzoic acid 0.01     7. Para-hydroxybenzoic acid 0.01     8. Transcinnamic acid 0.03     9. Scutellariae rhizome or root bark 50% ethanol extract 1.0    10. Pleurotus rhizome or root bark 50% ethanol extract 1.0    11. Carboxymethyl chitin solution 1.0    12. Vitamin E derivative 0.5    13. Antibacterial and antiseptic (paraben) 0.1    14. Perfume (sage water) appropriate amount    15. Residue to make purified water 100

[0130] (Prescription example 25) Hair growth and hair nourishing agent Mass%     1.Ethanol 60.0     2. Paracoumaric acid 0.01     3. Ferulic acid 0.04     4. Vitamin E derivative 0.5     5. Capsicum tincture 0.5     6. Resorcin 0.5     7.Dipotassium glycyrrhizinate 0.5     8. Carboxymethyl chitin solution 0.5     9. Pig hematin solution 0.5    10. Pig mucin solution 0.5    11. Amino acids (glycine, glutamine, etc.) 0.5    12. Antibacterial and antiseptic (paraben) 0.1    13. Fragrance (rosemary water) Suitable amount    14. Purified water 100 residue

[0131] (Prescription example 26) Hair growth and hair nourishing agent mass%     1.Ethanol 60.0     2. Phloretin 0.01     3. Salicylic acid 0.01     4. Benzoic acid 0.03     5. Cantharis tincture 0.5     6. Pantothenic acid derivative 0.5     7. Glycyrrhizic acid 0.5     8. Resorcin 0.5     9. Salicylic acid 0.5    10.Hydroxyethyl chitosan solution 0.5    11. Elastin hydrolyzate 0.5    12. Antibacterial and antiseptic (paraben) 0.1    13. Perfume (Lavender water) Suitable amount    14. Purified water 100 residue

[0132] (Prescription example 27) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 2.0     4.Parahydroxybenzoic acid 0.01     5. Transcinnamic acid 0.01     6. Paracoumaric acid 0.03     7. Dye (Gunjo green) Appropriate amount

[0133] (Prescription example 28) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 4.0     4. Ferulic acid 0.01     5. Phloretin 0.01     6. Salicylic acid 0.03     7. Satsuma mandarin 50% ethanol extract dry powder 1.0     8. Iris leaf or root 70% ethanol extract dry powder 1.0     9. Apple juice powder 1.0    10. Dye (Gunjou, chromium hydroxide)    11. Fragrance (Rome chamomile water) Suitable amount

(Formulation Example 29) A coating protective agent gauze or liniment cloth is impregnated with a formulation solution in which an appropriate amount of benzoic acid and para-hydroxybenzoic acid, an antibiotic, an anti-inflammatory agent, etc. is impregnated and attached to the wound. Alternatively, transcinnamic acid and paracoumaric acid may be directly sprayed locally and covered with gauze or the like.

[0135] (Prescription example 30) Oral cooling agent Mass%     1. Ethanol 20.0     2. Glycerin 15.0     3. Polyoxyethylene hydrogenated castor oil 1.0     4. Saccharin 0.2     5.Chlorhexidine 0.01     6. Ferulic acid 0.01     7. Phloretin 0.01     8. Salicylic acid 0.03     9. Dye (Gunzhou Green) Appropriate amount    10. Residue to make purified water 100

[0136] (Prescription example 31) Detergent for tableware Mass%     1. Alkyl (C12) glucoside 20.0     2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0     3. Glycerin 2.0     4. Ethanol 5.0     5. Benzoic acid 0.01     6. Para-hydroxybenzoic acid 0.01     7. Transcinnamic acid 0.03     8. Residue to make purified water 100

[0137] (Prescription example 32) Mentsuyu mass%     1. Soy sauce 80.0     2. Black vinegar 2.0     3. Glucose 13.0     4. Sodium glutamate 2.0     5. Paracoumaric acid 0.01     6. Ferulic acid 0.01     7. Phloretin 0.03

[0138] (Prescription example 33) Udon or buckwheat mass%     1. Wheat flour or buckwheat flour 93.0     2. Salt 1.0     3. Salicylic acid 0.01     4. Benzoic acid 0.01     5. Para-hydroxybenzoic acid 0.03

[0139] (Prescription example 34) Beverage mass%     1. Glucose liquid sugar 30.0     2. Grapefruit juice 45.0     3. Transcinnamic acid 0.01     4. Paracoumaric acid 0.01     5. Ferulic acid 0.03     6. Iyokan juice 5.0     7. Fructose 4.0     8. Fragrance suitable amount     9. Acidulant

[0140] (Formulation example 35) Bread mass%     1.flour 80.0     2. Salt 1.0     3. Glucose 7.0     4. Phloretin 0.01     5. Salicylic acid 0.01     6. Benzoic acid 0.03     7. Carboxymethyl chitin solution 2.0     8. Vitamin E 1.0     9. Heme iron 1.0

[0141] (Prescription example 36) Sausage mass%     1. Ground meat 80.0     2. Chicken egg 10.0     3. Spice 2.0     4. Seasoning 2.0     5. Para-hydroxybenzoic acid 0.01     6. Transcinnamic acid 0.01     7. Paracoumaric acid 0.03     8. Capsicum extract 4.0

[0142] (Formulation Example 37) gum mass%     1.Menthol Micron 30.0     2. Grapefruit flavor 50.0     3. Lemon flavor 14.0     4. Ferulic acid 0.01     5. Phloretin 0.01     6. Salicylic acid 0.03     7. Tannin 2.0

[0143] (Prescription example 38) Miso soup mass%     1. Tofu 30.0     2. Deep fried 5.0     3. carrot 5.0     4. Burdock 5.0     5. Chinese cabbage 5.0     6. Red miso 20.0     7. Benzoic acid 0.01     8. Parahydroxybenzoic acid 0.01     9. Transcinnamic acid 0.03    10. The remaining amount of bonito dashi 100

[0144] (Prescription example 39) Cookie mass%     1.milk 62.0     2. Whole egg 14.0     3. Sugar 12.5     4. Constarch 5.0     5. Salt 0.5     6. Paracoumaric acid 0.01     7. Ferulic acid 0.01     8. Phloretin 0.03     9. Fragrance suitable amount

(Test 4) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. The use test was conducted by 10 people aged between 30 and 50 years old who suffer from dry skin and dull skin, twice daily in the morning and at night, and after washing the face with an appropriate amount of the emulsion of Prescription Example 1 for 3 months on the face. It was done by applying over
As a control, transcinnamic acid, paracoumaric acid, ferulic acid, which is classified as a phenylpropanoid of the present invention from emulsion, salicylic acid, which is classified as chalcone and phloretin and a benzene derivative, benzoic acid, and parahydroxybenzoic acid are used as controls. The product except for was prepared in the same manner was used. In addition, the evaluation method was performed according to the following criteria, and the results are shown in Table 2, and the numerical values in the table represent the number of people. No one complained of skin abnormality during the period of use.

[Effect of improving skin feel] Effective: Dry skin and gloss of the skin were increased, and the skin was improved. Slightly effective: Dry skin and gloss of the skin were slightly increased, and the skin was improved. Ineffective: No change from before use.

[0147]

(Test Results) As shown in Table 2, transcinnamic acid, paracoumaric acid, ferulic acid classified as phenylpropanoids of the present invention, phloretin classified as chalcone, and salicylic acid classified as benzene derivative, benzoic acid, It has been confirmed that the emulsion containing para-hydroxybenzoic acid significantly gives the skin a shine and improves dry skin.

(Test 5) Use effect test The effect of actually using the food of the present invention was examined. The use test was conducted by 10 people aged 30 to 50 who suffer from dry skin and dull skin, each time twice a day in the morning and at night, and one bread of Prescription Example 35 (about 50 times a time).
I had them eat and drink g) for 3 months. In addition, as controls, transcinnamic acid classified as phenylpropanoids of the present invention from bread, paracoumaric acid, ferulic acid, phloretin classified as chalcone, and salicylic acid classified as benzene derivative, benzoic acid, parahydroxybenzoic acid. The product except for was prepared in the same manner was used. The evaluation method was carried out according to the following criteria, and the results are shown in Table 3 and the numerical values in the table represent the number of people. No one complained of skin abnormality during the period of use.

[Effect of improving skin feel] Effective: Dry skin and gloss of the skin were increased, and the skin was improved. Slightly effective: Dry skin and gloss of the skin were slightly increased, and the skin was improved. Ineffective: No change from before use.

[0151]

(Test Results) As shown in Table 3, transcinnamic acid, paracoumaric acid, ferulic acid classified as phenylpropanoids of the present invention, phloretin classified as chalcone, and salicylic acid classified as benzene derivative, benzoic acid, It was confirmed that the bread containing para-hydroxybenzoic acid significantly gives the skin a shine and improved dry skin.

[0153]

The phenylpropanoids (transcinnamic acid, paracoumaric acid, ferulic acid, etc.), chalcones (floretin, etc.), and benzene derivatives (salicylic acid, benzoic acid, parahydroxybenzoic acid, etc.) of the present invention have an inhibitory effect on pentosidine formation. It was confirmed that they have it, and it came to be applied as a Maillard reaction inhibitor. Furthermore, it is safe for human or animal use internally or externally. Therefore, it can be effectively used as a Maillard reaction inhibitor and can be applied to preparations in any form (medicines, quasi drugs, cosmetics, foods). It is also effective in preventing and improving dry skin by giving the skin a glossy finish, and reducing skin elasticity such as wrinkles, tarmi and kusumi, browning of the skin, aging of the skin, complications derived from diabetes, etc. It can also be used for the prevention and amelioration of various diseases related to the inhibition of the Maillard reaction, and an antiaging effect and the like can be expected.

[Procedure amendment]

[Submission date] January 23, 2002 (2002.1.2
3)

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be corrected] Claim 6

[Correction method] Change

[Correction content]

[Procedure Amendment 2]

[Document name to be amended] Statement

[Name of item to be corrected] Claim 7

[Correction method] Change

[Correction content]

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/48 A61K 31/05 31/05 31/192 31/192 A61P 17/16 A61P 17/16 43 / 00 43/00 A23L 2/00 F (72) Inventor Nobuyasu Matsuura 5180 Kurokawa, Kosugi-cho, Imizu-gun, Toyama Prefecture Toyama Prefectural University Student Engineering Research Center F-term (reference) 4B017 LC03 LK06 LK08 LL09 4B018 LB08 MD08 MD09 MD10 ME10 4C083 AA082 AA112 AA122 AB032 AB152 AC022 AC072 AC102 AC122 AC182 AC242 AC311 AC312 AC352 AC422 AC442 AC471 AC472 AC481 AC482 AC532 AC542 AC582 AC642 AC692 AC852 AD512 AD532 AD642 AD662 CC02 CC04 CC05 CC06 CC07 CC19 CC23 CC25 CC33 DD33 DD39 CC31 DD33 DD EE12 EE17 FF01 4C086 AA01 AA02 DA17 MA03 MA63 NA14 ZA89 ZC52 4C206 AA01 AA02 CB19 DA16 DA17 DA18 DA19 DA21 MA03 NA14 ZA89 ZC52

Claims (7)

[Claims] 1. A Maillard reaction inhibitor containing one or more selected from the group consisting of phenylpropanoids, chalcones and benzene derivatives. 2. The Maillard reaction inhibitor according to claim 1, which has an inhibitory effect on pentosidine production. 3. The Maillard reaction inhibitor according to claim 1, wherein the phenylpropanoid is one or more selected from transcinnamic acid, paracoumaric acid, and ferulic acid. 4. The Maillard reaction inhibitor according to claim 1, wherein the chalcone is phloretin. 5. The Maillard reaction inhibitor according to claim 1, wherein the benzene derivative is one or more selected from salicylic acid, benzoic acid and parahydroxybenzoic acid. 6. A skin external preparation containing one or more kinds selected from the Maillard reaction inhibitors according to any one of claims 1 to 6. 7. A food or drink comprising one or more selected from the Maillard reaction inhibitors according to any one of claims 1 to 6.