JP2003277220A - External preparation for skin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an emulsion-type external preparation for skins which contains a large amount of a glycerol monofatty acid ester, possesses a wide viscosity range and an excellent shelf stability. <P>SOLUTION: The emulsified external preparation for skins contains (A) a glycerol monofatty acid ester, (B) microbial lipopeptides and (C) a higher fatty acid which is in a liquid state at 25°C. In the external preparation, (C) the higher fatty acid is a branched fatty acid. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin. More specifically, it relates to an emulsion type external preparation for external use which has a wide viscosity range while containing a large amount of glycerin monofatty acid ester and is excellent in storage stability.

[0002]

BACKGROUND OF THE INVENTION Glycerin monofatty acid ester is a general-purpose raw material for external preparations for skin, and is widely used as a lipophilic surfactant in lotions, emulsions, gels, creams, cleansing agents and the like.

[0003]

However, glycerin monofatty acid ester often crystallizes in the preparation, and when it is incorporated in a large amount in the preparation, the viscosity is remarkably increased. Therefore, despite being strongly desired, while preparing a large amount of glycerin monofatty acid ester, it is possible to prepare a formulation in a wide viscosity range (milky liquid to creamy to solid) and to have excellent storage stability. It was very difficult to get.

[0004]

In view of such circumstances, the present invention provides an emulsion type external preparation for skin which has a wide viscosity range while containing a large amount of glycerin monofatty acid ester and is excellent in storage stability. With the goal.

[0005]

Means for Solving the Problems As a result of various studies, the present inventors have found that in an emulsion type external preparation for skin containing glycerin monofatty acid ester, lipopeptides derived from a microorganism and higher fatty acid liquid at 25 ° C. are mixed. By doing so, they have found that the above-mentioned object can be achieved, and completed the present invention.

That is, claim 1 of the present invention comprises (A) a glycerin monofatty acid ester, (B) a lipopeptide derived from a microorganism, and (C) an emulsified liquid fatty acid at 25 ° C. Type external preparation for skin.

A second aspect of the present invention is the emulsion type external preparation for skin according to the first aspect, characterized in that (C) the higher fatty acid liquid at 25 ° C. is a branched fatty acid.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The structure of the present invention will be described in detail below.

The glycerin monofatty acid ester (A) used in the present invention is a substance known as a raw material for cosmetics, and specific examples thereof include glyceryl monostearate, glyceryl monoisostearate, glyceryl monooleate, and glyceryl monohydroxystearate. , Glycerin monomyristate, etc., and these can be used alone or in combination of two or more.

The amount of glycerin monofatty acid ester (A) used in the present invention is preferably 2 to 28% by mass (hereinafter simply abbreviated as%), and particularly preferably, based on the total amount of the emulsion type external preparation for skin. It is 4 to 16%. If the blending amount is outside the range of 2 to 28%, a stable external preparation for skin may not be obtained in some cases.

The (B) microbial-derived lipopeptides used in the present invention are known substances as cosmetic raw materials,
It is preferable to use a lipopeptide compound derived from a prokaryote such as a microorganism of the genus Bacillus as described in JP-A-2000-327591. Examples of lipopeptides derived from microorganisms include surfactin [Bioc
hem.Bioph.Res.Commun., 31: 488-494, (1968)], Pripastatin [J. Antibiot., Vol. 39, No. 6, 745-761, (198
6)], Arthrofactin [J. Bacteriol., Vol.175, No.
20,6459-6466, (1993)], Iturin [Biochemistry, Vo
l.17, No.19,3992-3996, (1978)] Serawechin [J.Bac
teriol., Vol.174, No.6, 1769-1772, (1992)], and metal salts of carboxyl groups derived from amino acids which are their constituent units (alkali metal salts such as sodium, potassium and lithium, calcium, magnesium) Alkaline earth metal salts such as) and organic ammonium salts (trimethylamine salt, triethylamine salt, tributylamine salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt, lysine salt, arginine salt, choline salt, etc.) and the like. It is particularly preferable to use surfactin sodium (trade name: Aminofect, manufactured by Showa Denko KK).

The amount of the (B) microorganism-derived lipopeptides used in the present invention is preferably 0.05 to 9%, particularly preferably 0.1 to 5%, based on the total amount of the emulsion type external preparation for skin. %. If the blending amount is less than 0.05%, the object of the present invention may not be achieved, and if the blending amount exceeds 9%, an increase in the effect commensurate with the exceeding blending amount cannot be obtained. There are cases.

The higher fatty acid used in the present invention is a substance known as a raw material for cosmetics and may be liquid at 25 ° C., and examples thereof include unsaturated fatty acids and branched fatty acids.
Examples of unsaturated fatty acids include oleic acid, palmitoleic acid, linoleic acid, and linolenic acid. Examples of branched fatty acids include soybean oil, vegetable oils such as cottonseed oil, or branched fatty acids extracted from hydrogenated oil, and vegetable oils as raw materials. The branched fatty acid produced as a by-product during the production of dimer acid In particular, saturated branched fatty acids are desirable from the aspect of taste and the like, and isostearic acid is particularly desirable.

The amount of the higher fatty acid (C) liquid at 25 ° C. used in the present invention is preferably 0.01 to 60%, and particularly preferably 0.05 to 60%, based on the total amount of the emulsion type external preparation for skin. 40%. If the blending amount is less than 0.01%, the object of the present invention may not be achieved, and if the blending amount exceeds 60%, the effect commensurate with the exceeding blending amount cannot be obtained. There are cases.

In the emulsion type external preparation for skin of the present invention, in addition to the above-mentioned essential components, other components such as decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane, etc. within a range to achieve the object of the present invention, Silicone oils such as methylphenylpolysiloxane and dimethylpolysiloxane, hydrocarbons such as paraffin and vaseline, olive squalane, rice squalane, rice bran oil, olive oil, soybean oil, rice germ oil, jojoba oil, castor oil, safflower oil, sunflower Oils, vegetable oils such as macadamia nut oil, waxes such as beeswax, syrup and carnauba wax, octyldodecyl myristate, ester oils such as cetyl palmitate, higher alcohols such as cetanol, behenyl alcohol, stearyl alcohol and isostearyl alcohol, cholesterol, phytoste Sterols such Lumpur, branched fatty acid cholesterol esters, sterol fatty acid esters such as macadamia nut oil fatty acid phytosterol esters, sodium cetyl sulfate, N- stearoyl -L
Anionic surfactant such as glutamate, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid ester, polyglycerin fatty acid ester,
Nonionic surfactants such as sucrose fatty acid ester, cationic surfactants such as tetraalkylammonium salt, amphoteric surfactants such as betaine type, sulfobetaine type and sulfoamino acid type, lecithin, hydrogenated lecithin, lysophosphatidyl Natural surfactants such as choline, ceramide, cerebroside, silicone-based surfactants such as polyether-modified silicone and amino-modified silicone, processed oils such as hardened oil, glyceryl triisostearate, glyceryl tri (capryl / capric acid) , Triglycerides such as glyceryl tri-2-ethylhexanoate, tar pigments, coloring pigments such as iron oxide, preservatives such as paraben and phenoxyethanol, pigments such as titanium oxide and zinc oxide, dibutylhydroxytoluene, dehydrodicresol and the like. Antioxidants, ethanol, etc. Grade alcohol, sodium chloride,
Inorganic salts such as magnesium chloride, sodium sulfate, potassium nitrate and sodium silicate, organic acid salts such as sodium succinate and sodium aspartate, ethanolamine hydrochloride, ammonium nitrate, arginine hydrochloride, phosphate, citrate, acetate, carbonate, Trishydroxymethylaminomethane hydrochloride, salts such as diisopropylamine dichloroacetate, carboxyvinyl polymer, xanthan gum, carrageenan, pectin, thickeners such as alkyl modified carboxyvinyl polymer, chelating agents such as edetic acid,
Neutralizer such as potassium hydroxide, diisopropanolamine, triethanolamine, dipropylene glycol,
Polyhydric alcohols such as 1,3-butylene glycol, glycerin, propylene glycol, sorbitol, maltitol, diglycerin and acetylglucosamine, hydroxy acids such as lactic acid, biopolymers such as hyaluronic acid, collagen and silk protein, lactic acid bacteria, yeast Culture products such as chamomile, assembly, aloe, peach, carrot, horsetail, mulberry, peach leaf, sage, loquat leaf, cucumber, Ivy, hibiscus, turmeric, rosemary, sardine, clove, fennel, prune, Licorice plant extract, serine, threonine, N-methylglycine, N
-Amino acids such as methyl-l-serine, aminobutyric acid and hydroxyaminobutyric acid, ultraviolet absorbers such as hydroxymethoxybenzophenone sulfonate, vitamins A and B
, Vitamins such as Cs, Es, glycyrrhizinate,
Fragrances and the like can be used, but are not limited thereto.

The emulsion type external preparation for skin of the present invention can be produced according to a conventional method, and by appropriately selecting the compounding amounts of the above-mentioned essential components and optional components and using them, a wide range of emulsions to creams to solids can be obtained. The viscosity range can be easily obtained.

Further, the emulsion type external preparation for skin of the present invention can be applied to cosmetics, quasi drugs, pharmaceuticals and the like, and its usage forms are, for example, beauty solution, lotion, emulsion,
Examples include packs, makeup bases, makeup charges, massage charges, cleansing charges and the like.

[0018]

EXAMPLES The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to these examples. In addition, all units of composition are mass%.

Prior to the examples, a storage stability test using the external preparation for skin of the present invention and the external preparation for skin of Comparative Example will be described.

<Storage Stability Test> A sample was placed in a glass bottle, and the condition and appearance after standing at room temperature for 3 weeks were observed. If any abnormality was observed (separation or precipitation), it was represented by x, and no abnormality was observed. Is represented by a circle.

Examples 1 to 5 and Comparative Examples 1 to 4 (Emulsion) An emulsion having the composition shown in Table 1 was prepared according to the following preparation method, and the above test was carried out. The results are also shown in Table 1.

(1) Composition

[Table 1]

(2) Preparation Method Components a and b are each melted at 80 ° C. and then mixed,
The emulsion was prepared by cooling with stirring and cooling to 30 ° C.

(3) Results As is clear from Table 1, the emulsion according to the present invention (Examples 1 to 1)
In 5), excellent storage stability was recognized as compared with the emulsions of Comparative Examples 1 to 4.

Example 6, Comparative Examples 5 to 14 (Cream) Creams having the compositions shown in Table 2 were prepared according to the following preparation method, and the above-mentioned tests were carried out. The results are also shown in Table 2.

(1) Composition

[Table 2]

(2) Preparation Method Components a and b are each melted at 80 ° C. and then mixed,
Cooled with stirring and cooled to 30 ° C. to prepare a cream.

(3) Results As is clear from Table 2, the cream according to the present invention (Example 6) is superior to the creams of Comparative Examples 5 to 14 in which other oil agents which are liquid at 25 ° C. are blended. The storage stability was confirmed.

Examples 7 to 9 (Emulsion) An emulsion was prepared according to the following composition and preparation method, and the above test was carried out.

[0030] (1) Composition                                   Example 7 Example 8 Example 9 Ingredient a Isostearic acid 1.0 1.0 3.0 Glycerin monostearate 4.0 4.0 4.0 Behenyl alcohol 2.0 2.0 2.0 White beeswax 1.0 1.0- Cetyl myristate 1.0 1.0 1.0 Sorbitan sesquioleate 1.0 1.0 1.0 Long-chain branched fatty acid cholesteryl * 1 0.1 0.1 0.1 Hydrogenated lecithin 0.1 0.1 0.1 Plant squalane 5.0 5.0 5.0 Octyldodecyl myristate 5.0 5.0 5.0 Ingredient b Surfactin sodium 0.1 1.0 0.1 1,3-butylene glycol 5.0 10.0 0.5 Sorbitol liquid 5.0 5.0 5.0 Polyethylene glycol 4000 0.2 0.2 0.2 Carboxy vinyl polymer 0.1 0.1 0.1 Methyl paraoxybenzoate 0.2 0.2 0.2 Mevalonolactone 0.1 0.1 0.1 Disodium edetate 0.2 0.2 0.2 Raspberry ketone glucoside 0.05 0.05 0.05 Sodium chloride 0.1 0.1 0.1 Dipropylene glycol 0.1 0.1 0.1 Concentrated glycerin 5.0 5.0 5.0 Raffinose 0.1 0.1 0.1 0.1 Ascorbic acid 2-glucoside 0.1 0.1 0.1 Carboxymethyl cellulose 0.05 0.05 0.05 Purified water Residual amount Residual amount * 1 Product name: YOFCO CLE-NH (Nippon Seika)

(2) Preparation Method Components a and b are each melted at 80 ° C. and then mixed,
The emulsion was prepared by cooling with stirring and cooling to 30 ° C.

(3) Results The emulsions according to Examples 7 to 9 were found to have excellent storage stability.

Examples 10 to 12 (Beauty solution) A beauty essence was prepared according to the following composition and preparation method, and the above test was carried out.

[0034] (1) Composition                                       Example 10 Example 11 Example 12 Ingredient a Isostearic acid 1.0 5.0 1.0 Glycerin monostearate 4.0 4.0 4.0 Hexyldecanol 2.0 2.0 2.0 Nicotinic acid dl-α-tocopherol 0.1 0.1 0.1 POE (60) hydrogenated castor oil 0.2 0.2 0.2 Spherical silicon powder * 2 1.0 1.0 1.0 Liquid paraffin 3.0 3.0 3.0 Jojoba oil 3.0 3.0 3.0 Macadamia nut oil fatty acid phytosteryl 1.0 1.0 1.0 Isocetyl myristate 5.0 5.0 5.0 Glyceryl triisostearate 2.0 2.0 2.0 Isostearic acid hydrogenated castor oil 1.0 1.0 1.0 Phytosterol 0.1 0.1 0.1 Ingredient b Surfactin sodium 1.0 1.0 0.3 1,3-butylene glycol 3.0 3.0 3.0 Concentrated glycerin 3.0 3.0 3.0 3.0 Methyl paraoxybenzoate 0.2 0.2 0.2 N-acetylglucosamine 0.1 0.1 0.1 Ascorbic acid phosphate                     Magnesium 0.1 0.1 0.1 γ-aminobutyric acid 0.2 0.2 0.2 Sodium N-stearoyl glutamate 0.1 0.1 0.1 Alkyl-modified carboxyvinyl polymer 0.1 0.1 0.1 Nicotinic acid amide 0.1 0.1 0.1 Sarcosine 0.1 0.1 0.1 Chinpi extract 0.1 0.1 0.1 Yeast extract 0.1 0.1 0.1 Licorice extract 0.1 0.1 0.1 N-methyl-L-serine 0.1 0.1 0.1 Purified water Residual amount Residual amount * 2 Product name: Tospearl (manufactured by Toshiba Silicon)

The components a and b were each melted at 80 ° C., then mixed, cooled with stirring and cooled to 30 ° C.,
A beauty essence was prepared.

(3) Results The beauty essences of Examples 10 to 12 were confirmed to have excellent storage stability.

When any of the emulsified external preparations for skin of the present invention is used, no redness, inflammation, or other side effects are observed on the skin, and the external preparation for emulsified skin according to the present invention is safe. It was clear that it was also excellent in sex.

[0038]

INDUSTRIAL APPLICABILITY As described above, it is apparent that the present invention provides a milky liquid external preparation for skin which has a wide viscosity range while containing a large amount of glycerin monofatty acid ester and is excellent in storage stability.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 9/10 A61K 9/10 47/12 47/12 47/14 47/14 47/42 47/42 ( 72) Inventor Etsuko Kobayashi 5-328, Kotobukicho, Odawara-shi, Kanagawa F-Term in Kanebo Co., Ltd. Cosmetic Research Center (reference) AC391 AC392 AC432 AC442 AC482 AC522 AC582 AC622 AD042 AD092 AD392 AD411 AD412 AD472 AD642 AD662 CC03 CC05 DD31 EE01 EE11

Claims (2)

[Claims] 1. (A) Glycerin monofatty acid ester,
(B) Microorganism-derived lipopeptides, and (C) 25 ° C.
An emulsion type external preparation for skin, characterized in that it contains a liquid higher fatty acid. 2. The emulsion-type external preparation for skin according to claim 1, wherein (C) the higher fatty acid liquid at 25 ° C. is a branched fatty acid.