JP2003275230A - Intraocular lens and manufacturing method thereof - Google Patents
Intraocular lens and manufacturing method thereofInfo
- Publication number
- JP2003275230A JP2003275230A JP2002080494A JP2002080494A JP2003275230A JP 2003275230 A JP2003275230 A JP 2003275230A JP 2002080494 A JP2002080494 A JP 2002080494A JP 2002080494 A JP2002080494 A JP 2002080494A JP 2003275230 A JP2003275230 A JP 2003275230A
- Authority
- JP
- Japan
- Prior art keywords
- intraocular lens
- moth
- eye structure
- rsm
- lens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 5
- 239000000463 material Substances 0.000 claims description 10
- 238000005422 blasting Methods 0.000 claims description 2
- 239000013043 chemical agent Substances 0.000 claims description 2
- 238000005530 etching Methods 0.000 claims description 2
- 239000010419 fine particle Substances 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 229920003002 synthetic resin Polymers 0.000 claims description 2
- 239000000057 synthetic resin Substances 0.000 claims description 2
- 238000001721 transfer moulding Methods 0.000 claims description 2
- 210000000695 crystalline len Anatomy 0.000 abstract description 40
- 208000002177 Cataract Diseases 0.000 abstract description 5
- 238000001356 surgical procedure Methods 0.000 abstract description 3
- 208000024891 symptom Diseases 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 8
- 239000010408 film Substances 0.000 description 8
- 229920005989 resin Polymers 0.000 description 7
- 239000011347 resin Substances 0.000 description 7
- 238000002834 transmittance Methods 0.000 description 6
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 4
- 239000004926 polymethyl methacrylate Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 210000001508 eye Anatomy 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000004925 Acrylic resin Substances 0.000 description 2
- 229920000178 Acrylic resin Polymers 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 210000005252 bulbus oculi Anatomy 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 229920005992 thermoplastic resin Polymers 0.000 description 2
- 229910004261 CaF 2 Inorganic materials 0.000 description 1
- 239000004641 Diallyl-phthalate Substances 0.000 description 1
- 239000004640 Melamine resin Substances 0.000 description 1
- 229920000877 Melamine resin Polymers 0.000 description 1
- 229910004298 SiO 2 Inorganic materials 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- 229920001807 Urea-formaldehyde Polymers 0.000 description 1
- 230000003667 anti-reflective effect Effects 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- QUDWYFHPNIMBFC-UHFFFAOYSA-N bis(prop-2-enyl) benzene-1,2-dicarboxylate Chemical compound C=CCOC(=O)C1=CC=CC=C1C(=O)OCC=C QUDWYFHPNIMBFC-UHFFFAOYSA-N 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- -1 etc. are preferable Polymers 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000004313 glare Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000005011 phenolic resin Substances 0.000 description 1
- 229920001483 poly(ethyl methacrylate) polymer Polymers 0.000 description 1
- 229920006122 polyamide resin Polymers 0.000 description 1
- 229920000412 polyarylene Polymers 0.000 description 1
- 229920005668 polycarbonate resin Polymers 0.000 description 1
- 239000004431 polycarbonate resin Substances 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920001225 polyester resin Polymers 0.000 description 1
- 239000004645 polyester resin Substances 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 239000009719 polyimide resin Substances 0.000 description 1
- 229920005672 polyolefin resin Polymers 0.000 description 1
- 229920001955 polyphenylene ether Polymers 0.000 description 1
- 229920005749 polyurethane resin Polymers 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
- 229920006305 unsaturated polyester Polymers 0.000 description 1
Landscapes
- Prostheses (AREA)
Abstract
(57)【要約】
【課題】白内障の手術治療として、水晶体を摘出して眼
内レンズを装着した患者が外光を眩しく感じる症状を改
善し得る眼内レンズとその製造方法を提供する。
【解決手段】眼内レンズの表面にモスアイ構造を有す
る。特にモスアイ構造を有する表面が、JIS B 0601
2001で定義される輪郭曲線の算術平均高さをRa(3)、輪
郭曲線要素の平均長さをRSm(3)としたとき、0.001μm＜
Ra(3)＜0.5μ、0.001μm＜RSm(3)＜0.5μm、かつ0.01＜
Ra(3)／RSm(3)＜2.0の関係を満たすことが好ましい。
(57) [Object] To provide an intraocular lens and a method for producing the same, which can improve a symptom in which a patient who removes a crystalline lens and wears an intraocular lens feels dazzling external light as a surgical treatment for cataract. A moth-eye structure is provided on the surface of an intraocular lens. Particularly, the surface having a moth-eye structure is JIS B 0601
When the arithmetic average height of the contour curve defined in 2001 is Ra ( 3 ) and the average length of the contour curve element is RSm ( 3 ), 0.001 μm <
Ra ( 3 ) <0.5μ, 0.001μm <RSm ( 3 ) <0.5μm, and 0.01 <
It is preferable to satisfy the relationship of Ra ( 3 ) / RSm ( 3 ) <2.0.
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、白内障の手術治療
法として広く普及している眼内レンズに関し、特に表面
に特定の構造を有する眼内レンズ及びその製造方法に関
する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an intraocular lens that is widely used as a surgical treatment method for cataract, and more particularly to an intraocular lens having a specific structure on its surface and a method for manufacturing the same.
【０００２】[0002]
【従来の技術】眼球の断面図を図４に示す。図４におい
て、Ｌは水晶体、Ｉは虹彩、Ｃは角膜、Ｒは網膜であ
る。白内障の患者の治療法として、水晶体Ｌを摘出して
その代替として眼内レンズを装着する方法がある。その
ような治療をした患者には、外光を眩しく感じると訴え
る患者が多い。2. Description of the Related Art A sectional view of an eyeball is shown in FIG. In FIG. 4, L is the lens, I is the iris, C is the cornea, and R is the retina. As a treatment method for a cataract patient, there is a method of removing the lens L and mounting an intraocular lens as an alternative thereto. Many patients who have undergone such treatment complain that they feel dazzling outside light.
【０００３】[0003]
【発明が解決しようとする課題】眩しく感じる原因には
いくつかの要因が考えられる。第１の原因としては、白
内障を発症した老人の水晶体は黄変していることがあ
り、黄変した水晶体を通した見え方に慣れていると、水
晶体を透明な眼内レンズで置き換えた場合に眩しく感じ
ることが考えられる。また、第２の原因として、水晶体
は屈折率分布型レンズであるために周囲の生体との屈折
率差には大きな差がなく、この界面での反射は問題にな
らなかったが、屈折率が均一な眼内レンズを装着するこ
とにより、周囲の生体との屈折率差による界面での反射
光が問題となることも考えられる。There are several possible causes for the feeling of glare. The first cause is that the lens of an elderly person with cataract has yellowed, and if the lens is replaced with a transparent intraocular lens when used to see through the yellowed lens. It is possible to feel dazzling. As the second cause, since the crystalline lens is a gradient index lens, there is no large difference in the refractive index difference with the surrounding living body, and reflection at this interface was not a problem, but the refractive index was By mounting a uniform intraocular lens, it is possible that reflected light at the interface due to the difference in refractive index from the surrounding living body becomes a problem.
【０００４】そこで、眼内レンズに紫外線吸収剤を含有
させたり、色素によって着色する等の対応が採られてき
たが、これらの方法によって改善は見られるが、第２の
原因の解決には至らず、より優れた解決法が求められて
いた。本発明者らは白内障の手術後、水晶体に代替した
眼内レンズ表面に反射防止効果を付与することにより、
周囲の生体との屈折率差により生じる反射を抑制して、
症状の改善を目指す方法を検討した。Therefore, measures such as incorporating an ultraviolet absorber into the intraocular lens and coloring with a dye have been taken. Although these methods can be improved, the second cause is not solved. Instead, a better solution was sought. After the cataract surgery, the present inventors have added an antireflective effect to the intraocular lens surface substituted for the lens,
Suppresses reflection caused by the difference in refractive index from the surrounding living body,
We examined ways to improve the symptoms.
【０００５】一般に反射防止技術には古くから多くの方
法が提案されている。例として、CaF2、ZnS、SiO2等の
無機化合物の薄膜を蒸着して多層膜にし、その干渉効果
により反射率を下げる方法、基材よりも低屈折率の材料
を基材上に塗布して反射率を下げる方法等が挙げられ
る。しかしこれらの方法の眼内レンズへの適用は、いず
れも、コーティングにレンズ基材とは異なる材質を用い
る為、生体への影響が懸念される。また仮に生体への影
響の少ない材料を使用したとしても、干渉効果を利用し
ている為、角度分散、波長分散の影響が避けられず、新
たな問題が生じる可能性がある。In general, many methods have been proposed for antireflection technology from old times. As an example, CaF 2 , ZnS, a method of evaporating a thin film of an inorganic compound such as SiO 2 to form a multilayer film, a method of lowering the reflectance due to the interference effect, a material having a lower refractive index than the base material is applied on the base material. And a method of lowering the reflectance. However, when any of these methods is applied to an intraocular lens, a material different from the lens base material is used for coating, and therefore there is a concern that it may affect the living body. Even if a material that has little influence on the living body is used, the influence of angular dispersion and chromatic dispersion cannot be avoided because the interference effect is used, and new problems may occur.
【０００６】[0006]
【課題を解決するための手段】本発明者らは、上記の問
題を解決すべく種々検討した結果、眼内レンズ表面にモ
スアイ構造と呼ばれる特定の構造を形成することによ
り、反射防止効果を得ることを見出して、本発明に到達
した。即ち、本発明の要旨は、表面にモスアイ構造を有
することを特徴とする眼内レンズと当該レンズの製造方
法に存する。As a result of various studies to solve the above problems, the present inventors obtained an antireflection effect by forming a specific structure called a moth-eye structure on the surface of an intraocular lens. The inventors have found that and reached the present invention. That is, the gist of the present invention resides in an intraocular lens characterized by having a moth-eye structure on the surface and a method for manufacturing the lens.
【０００７】[0007]
【発明の実施の形態】以下、本発明を詳細に説明する。
本発明は、眼内レンズの表面にモスアイ構造を形成する
ことを特徴とする。モスアイ構造により、眼内レンズと
生体組織の間の屈折率差を傾斜化し、レンズと生体組織
との間で生ずる反射を抑制することが可能となる、優れ
た眼内レンズを提供することが可能となる。BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail below.
The present invention is characterized in that a moth-eye structure is formed on the surface of the intraocular lens. With the moth-eye structure, it is possible to provide an excellent intraocular lens that makes it possible to incline the refractive index difference between the intraocular lens and the biological tissue and suppress the reflection that occurs between the lens and the biological tissue. Becomes
【０００８】本発明において、「モスアイ構造」とは、
物質表面に可視光の波長以下の大きさを有する構造を持
つ突起が密集した結果、表面の反射率が低減された構造
を指す。この構造はある種類の蛾の目に見られる構造で
あるため、「蛾の目」との意味で「モスアイ」（ｍｏｔ
ｈ−ｅｙｅ）構造と呼ばれ、スクリーン、ディスプレイ
等の反射防止膜に使用することが知られている（特表２
００１−５１７３１９公報参照）。In the present invention, the "moth-eye structure" means
This refers to a structure in which the reflectance of the surface is reduced as a result of densely gathering projections having a structure having a size equal to or less than the wavelength of visible light on the surface of the material. Since this structure is a structure found in the eyes of some kinds of moths, it means "moth eyes" (mot eye).
It is called an h-eye structure and is known to be used as an antireflection film for screens, displays and the like (Table 2).
001-517319).
【０００９】モスアイ効果の概要について図１に基づい
て説明する。図１には、屈折率n1の媒質から、屈折率n2
を有して表面に微細な凹凸形状を持つ媒質に光が入射し
た時の関係を示す。が入射光、がゼロ次の反射光、
が反射の＋１次光、が反射の−１次光、が透過ゼ
ロ次光、が透過の＋１次光、が透過の−１次光であ
る。これらの他に±２次、±３次等の高次の回折光があ
る。平滑な界面を有する媒質に光が入射した場合には、
入射光、反射光及び透過光（屈折光）のみの関係
を議論するが、表面に微細な凹凸が存在する場合にはそ
の他に、上記のような回折光の存在を議論することにな
る。この微細構造の周期をＬ、高さをhとして、入射す
る光の波長をλとした場合、ｉ番目の回折光の波数ベク
トルのＸ成分ｋixは微細構造の周期Λと入射光の波長λ
によって次のように決まる。The outline of the moth-eye effect will be described with reference to FIG. In FIG. 1, a medium having a refractive index n 1 is changed to a medium having a refractive index n 2
The relationship when light is incident on a medium having a fine irregular shape on its surface is shown. Is incident light, is zero-order reflected light,
Is the reflected + first-order light, is the reflected −first-order light, is the transmitted zero-order light, is the transmitted + first-order light, and is the transmitted −first-order light. In addition to these, there are high-order diffracted lights such as ± 2nd order and ± 3rd order. When light enters a medium with a smooth interface,
The relationship between only incident light, reflected light, and transmitted light (refracted light) will be discussed, but in the case where fine irregularities exist on the surface, the existence of diffracted light as described above will be discussed. When the period of this fine structure is L, the height is h, and the wavelength of the incident light is λ, the X component k ix of the wave number vector of the i-th diffracted light is the period Λ of the fine structure and the wavelength λ of the incident light.
Is determined as follows.
【数１】
ｋix＝（２πｎ1 ／λ）ｓｉｎα−ｉ２π／Λ
（α：入射角度、ｉ：回折光の次数）
回折光の波数ベクトルのＸ成分が入射光の波数ベクトル
の絶対値を超えると、回折光の境界面に垂直な成分（図
２のＺ方向成分）が純虚数となる。この回折光はエバネ
ッセント波になり、Ｚ方向の電場の振幅が急激に減衰す
るという現象が起こり、その時各回折光の間で振幅の再
配分が起こる。Λ＜（λ／２）の時、０次以外の透過と
反射の回折光がエバネッセント波となり、この時反射率
はアスペクト比ｈ／Λに依存し、表面にモスアイ構造が
ない平滑な場合の反射率に比べて減少する効果が確認さ
れる。理論計算より、アスペクト比が０．５＜ｈ／Λ＜
５．０の時、良好な反射防止効果を得られることが分か
っている。同時に表面にモスアイ構造がない平滑な場合
の透過光よりも透過率が増加する現象が観測される。
このような現象がモスアイ効果と呼ばれている。本発明
の眼内レンズの表面凹凸構造としてはJIS B 06012001
に記載の輪郭曲線の算術平均高さをRa(3)、輪郭曲線要
素の平均長さをRSm(3)とした時
0.001μm＜Ra(3)＜5.0μm かつ
0.001μm＜RSm(3)＜0.5μm かつ
0.01＜Ra(3)／RSm(3)＜5.0
の関係を満たしていることが望ましく、さらに望ましく
は
0.05μm＜Ra(3)＜5.0μm かつ
0.05μm＜RSm(3)＜0.5μm かつ
0.5＜Ra(3)／RSm(3)＜5.0
の関係を満たしていることが望ましい。K ix = (2πn 1 / λ) sin α-i2π / Λ (α: incident angle, i: order of diffracted light) The X component of the diffracted light wave vector exceeds the absolute value of the incident light wave vector. Then, the component perpendicular to the boundary surface of the diffracted light (Z direction component in FIG. 2) becomes a pure imaginary number. This diffracted light becomes an evanescent wave, and the phenomenon that the amplitude of the electric field in the Z direction is rapidly attenuated occurs. At that time, the redistribution of the amplitude occurs among the diffracted lights. When Λ <(λ / 2), the diffracted light of transmission and reflection other than the 0th order becomes an evanescent wave. At this time, the reflectance depends on the aspect ratio h / Λ, and the reflection when the surface has no moth-eye structure and is smooth A reduction effect is confirmed compared to the rate. From theoretical calculation, the aspect ratio is 0.5 <h / Λ <
It has been found that when 5.0, a good antireflection effect can be obtained. At the same time, a phenomenon in which the transmittance increases compared with the transmitted light when the surface has no moth-eye structure and is smooth is observed.
This phenomenon is called the moth-eye effect. As the surface uneven structure of the intraocular lens of the present invention, JIS B 0601 2001
When the arithmetic mean height of the contour curve described in 1 is Ra ( 3 ) and the mean length of the contour curve element is RSm ( 3 ), 0.001 μm <Ra ( 3 ) <5.0 μm and 0.001 μm <RSm ( 3 ) < 0.5 μm and 0.01 <Ra ( 3 ) / RSm ( 3 ) <5.0 are desirable, and more preferably 0.05 μm <Ra ( 3 ) <5.0 μm and 0.05 μm <RSm ( 3 ) <0.5 μm And it is desirable to satisfy the relationship of 0.5 <Ra ( 3 ) / RSm ( 3 ) <5.0.
【００１０】また、モスアイ構造は周期的でもランダム
な構造でも良い。一次元又は二次元的に周期的な回折格
子構造である場合は、その周期をＬ、深さをＨとした
時、０．０５μm＜Ｌ＜２．０μm、かつ０．０５μm＜
Ｈ＜５．０μm、かつ０．２＜Ｈ／Ｌ＜５．０を満たす
ことが好ましい。モスアイ構造を形成する眼内レンズは
特に限定されず、公知のいずれの形状や構造の眼内レン
ズにも適用可能である。例えば、眼内レンズには、支持
部と光学部とが別に作られ結合されるツーピース型眼内
レンズ（スリーピース型眼内レンズと呼ばれる場合もあ
る）と、支持部と光学部とが一体であるワンピース型眼
内レンズとがあり、どちらにも適用可能である。モスア
イ構造は、光学部の角膜側、網膜側の両方の表面に設け
ることが望ましいが、片方のみでもよい。The moth-eye structure may be either periodic or random. In the case of a one-dimensional or two-dimensional periodic diffraction grating structure, when the period is L and the depth is H, 0.05 μm <L <2.0 μm and 0.05 μm <
It is preferable that H <5.0 μm and 0.2 <H / L <5.0 are satisfied. The intraocular lens forming the moth-eye structure is not particularly limited, and the intraocular lens having any known shape and structure can be applied. For example, in an intraocular lens, a two-piece type intraocular lens (sometimes referred to as a three-piece type intraocular lens) in which a support portion and an optical portion are separately formed and combined, and a support portion and an optical portion are integrated. There is a one-piece type intraocular lens, and it is applicable to both. The moth-eye structure is preferably provided on both the corneal side and the retina side of the optical section, but only one side may be provided.
【００１１】眼内レンズを構成する材料は特に限定され
ず、理論的にはスチレン系樹脂、アクリル系樹脂、芳香
族ポリカーボネート樹脂、非晶質ポリオレフィン樹脂、
ポリアミド樹脂、芳香族ポリエステル樹脂、ポリフェニ
レンエーテル樹脂及びポリアリーレンスルフィト樹脂等
の熱可塑性樹脂、またはフェノール樹脂、ユリア樹脂、
メラミン樹脂、不飽和ポリエステル、エポキシ樹脂、ジ
アリルフタレート樹脂、ポリウレタン樹脂、ケイ素樹
脂、ポリイミド樹脂等の非熱可塑性樹脂の合成樹脂や、
ガラス、シリコーン等の無機非晶質物質が使用可能であ
る。しかし、生体適合性、機械加工性、透明性の観点か
らポリメチルメタクリレート、ホ゜リエチルメタクリレー
ト、アクリル樹脂、シリコーン等が好ましく、特にポリ
メチルメタクリレートが好ましい。The material forming the intraocular lens is not particularly limited, and theoretically, a styrene resin, an acrylic resin, an aromatic polycarbonate resin, an amorphous polyolefin resin,
Polyamide resin, aromatic polyester resin, thermoplastic resin such as polyphenylene ether resin and polyarylene sulfite resin, or phenol resin, urea resin,
Synthetic resin of non-thermoplastic resin such as melamine resin, unsaturated polyester, epoxy resin, diallyl phthalate resin, polyurethane resin, silicon resin and polyimide resin,
Inorganic amorphous materials such as glass and silicone can be used. However, from the viewpoints of biocompatibility, machinability, and transparency, polymethyl methacrylate, polyethyl methacrylate, acrylic resin, silicone, etc. are preferable, and polymethyl methacrylate is particularly preferable.
【００１２】モスアイ構造の形成方法は特に限定され
ず、スタンパーによる転写成型、微粒子吹き付けによる
ブラスト加工、化学薬品によるエッチング等を適宜採用
することができる。上述したように、眼内レンズ表面に
モスアイ構造を形成すると、反射率が低くなり、眼内レ
ンズと生体組織との屈折率差による反射を低減できる。
例えば、ポリメチルメタクリレート樹脂フィルムの表面
にスタンパーによりモスアイ構造を形成し、形成された
構造を原子間力顕微鏡（ＮＡＮＯＳＣＯＰＥ−ＩＩＩ。
デジタルインスツルメント社製）で測定した結果を図２
に示す。この表面構造の凹凸はＪＩＳ Ｂ ０６０１
2001で定義される輪郭曲線の算術平均高さをRa(3)、輪
郭曲線要素の平均長さをRSm(3)としたとき、Ra(3)が0.1
5μm、RSm(3)が約0.25μmであった。次にこのサンプル
の透過率を測定した結果を図３に、横軸に波長をnm単位
で示し、縦軸に透過率を％で示す。また、比較のためモ
スアイ構造を形成する前のポリメチルメタクリレート樹
脂フィルムの透過率を示す。このグラフからわかるよう
に、モスアイ構造を表面に形成したフィルムの透過率
は、測定した全波長領域にわたって高い水準を示す。従
って、このモスアイ構造を眼内レンズに用いれば、反射
率が低減されることがわかる。The method for forming the moth-eye structure is not particularly limited, and transfer molding with a stamper, blasting by spraying fine particles, etching with a chemical agent, etc. can be appropriately adopted. As described above, when the moth-eye structure is formed on the surface of the intraocular lens, the reflectance becomes low, and the reflection due to the difference in the refractive index between the intraocular lens and the biological tissue can be reduced.
For example, a moth-eye structure is formed on the surface of a polymethylmethacrylate resin film by a stamper, and the formed structure is analyzed by an atomic force microscope (NANOSCOPE-III.
Figure 2 shows the results measured with Digital Instruments.
Shown in. The unevenness of this surface structure is according to JIS B 0601.
When the arithmetic mean height of the contour curve defined in 2001 is Ra ( 3 ) and the mean length of the contour curve element is RSm ( 3 ), Ra ( 3 ) is 0.1
5 μm, RSm ( 3 ) was about 0.25 μm. Next, the results of measuring the transmittance of this sample are shown in FIG. 3, in which the abscissa indicates the wavelength in nm and the ordinate indicates the transmittance in%. For comparison, the transmittance of the polymethylmethacrylate resin film before forming the moth-eye structure is also shown. As can be seen from this graph, the transmittance of the film having the moth-eye structure formed on the surface shows a high level over the entire measured wavelength region. Therefore, it can be seen that the reflectance is reduced by using this moth-eye structure in the intraocular lens.
【００１３】[0013]
【発明の効果】以上のように、モスアイ構造により反射
率が低減されるので、表面にモスアイ構造を付与した眼
内レンズで代替することにより眩しく感じる症状が緩和
される。As described above, since the reflectance is reduced by the moth-eye structure, the phenomenon of feeling dazzling can be alleviated by substituting the intraocular lens having the moth-eye structure on the surface.
【図１】モスアイ構造による反射防止効果を説明するた
め、凹凸境界面の断面を示す模式図である。FIG. 1 is a schematic diagram showing a cross section of an uneven boundary surface for explaining an antireflection effect by a moth-eye structure.
【図２】モスアイ構造を有するフィルムを測定した結果
を示す図である。FIG. 2 is a view showing a result of measuring a film having a moth-eye structure.
【図３】モスアイ構造を有するフィルムと有さないフィ
ルムの、波長毎の透過率を示す図である。FIG. 3 is a diagram showing the transmittance for each wavelength of a film having a moth-eye structure and a film having no moth-eye structure.
【図４】眼球の断面図を示す模式図である。FIG. 4 is a schematic diagram showing a cross-sectional view of an eyeball.
１ 入射光 ２ ゼロ次の反射光 ５ 透過ゼロ次光 1 incident light 2 Zero-order reflected light 5 Zero-order transmitted light
Claims (4)
する眼内レンズ。1. An intraocular lens having a moth-eye structure on its surface.
012001で定義される輪郭曲線の算術平均高さをRa(3)、
輪郭曲線要素の平均長さをRSm(3)としたとき、 0.001μm＜Ra(3)＜5.0μm かつ 0.001μm＜RSm(3)＜0.5μm かつ 0.01＜Ra(3)／RSm(3)＜5.0 の関係を満たしていることを特徴とする請求項１記載の
眼内レンズ。2. A surface having a moth-eye structure is JIS B 06.
The arithmetic mean height of the contour curve defined by 01 2001 is Ra ( 3 ),
When the average length of the contour curve element is RSm ( 3 ), 0.001μm <Ra ( 3 ) <5.0μm and 0.001μm <RSm ( 3 ) <0.5μm and 0.01 <Ra ( 3 ) / RSm ( 3 ) < The intraocular lens according to claim 1, wherein the relationship of 5.0 is satisfied.
形成されていることを特徴とする請求項１又は２記載の
眼内レンズ。3. The intraocular lens according to claim 1, wherein the lens is made of a synthetic resin or an inorganic amorphous material.
型、微粒子吹き付けによるブラスト加工又は化学薬品に
よるエッチングによって形成することを特徴とする請求
項１ないし３のいずれか１項記載の眼内レンズの製造方
法。4. The method for producing an intraocular lens according to claim 1, wherein the moth-eye structure is formed by transfer molding with a stamper, blasting with fine particle spraying, or etching with a chemical agent. .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002080494A JP2003275230A (en) | 2002-03-22 | 2002-03-22 | Intraocular lens and manufacturing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002080494A JP2003275230A (en) | 2002-03-22 | 2002-03-22 | Intraocular lens and manufacturing method thereof |
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| Publication Number | Publication Date |
|---|---|
| JP2003275230A true JP2003275230A (en) | 2003-09-30 |
Family
ID=29206437
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002080494A Pending JP2003275230A (en) | 2002-03-22 | 2002-03-22 | Intraocular lens and manufacturing method thereof |
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