JP2003270241A - Health management device - Google Patents

Abstract

(57) [Summary] [Problem] To easily measure urine glucose in a low concentration range and easily manage diabetes risk at home and in individuals. SOLUTION: The urine sugar measuring device by the enzyme electrode method is 0 to 10
A low-concentration urine sugar of 0 mg / dL is measured several times a month, and data processing is performed, for example, every three months (ST41). When the average value every three months is 30 or less, the result is reported as “low risk” and the data processing result is reported. (ST44, ST48) If the average value every three months is 30 to 50, it is "risk increase", and the data processing result is reported as a need for improvement of some lifestyle (ST4).
(5, ST47) If the average value every three months exceeds 50, it is "risk large" and it is notified that the lifestyle habits need to be improved immediately (ST45, ST46).

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a health care device for measuring a urinary sugar value in a low concentration range and judging the risk of diabetes from the measurement result.

[0002]

BACKGROUND OF THE INVENTION-Background-Diabetes is one of the major diseases that causes complications such as kidney disease, retinopathy and neuropathy, and that it is difficult to notice the progress of the disease. The survey estimates the number of patients to be approximately 14 million, including those who cannot be ruled out, and interest and motivation for lifestyle-related diseases, exercise, diet, and health management are increasing.

Attempts to prevent the onset of diabetes mellitus 1
It has been tried since the early 990's, and active exercise therapy and diet therapy for borderline patients before the onset of diabetes promoted normalization of symptoms and reduced the incidence rate revealed in a study in Sweden and China. The current situation is that verification is being conducted by expanding the scale of research in the United States.

However, in reality, there are some people in their 40s to 50s who have a high risk of developing lifestyle-related diseases, although it is difficult to take time for health checkups and medical examinations due to their prime. In addition, the measurement technology as a primary preventive index that can be easily used at home or at work is not sufficient.

-Prior Art-A small self-monitoring blood glucose meter for directly measuring blood glucose level is commercially available as a measuring instrument as a primary preventive index which can be easily used at home or at work. However, since blood sampling is required, There are problems with resistance to blood sampling, pain during blood sampling, and infection after blood sampling, and it is only used by some diabetics, and has not been widely spread to general households.

Therefore, the urine sugar test for measuring the sugar content in urine has become widespread, and the most common one is the test strip method. The medical examination is always carried out as a simple diabetes screening. In general, it is assumed that urine sugar is detected when the urine sugar value is 100 mg / dL or more, and when this result is repeatedly reproduced, "diabetes is highly likely, so consult a doctor". The measurement accuracy of the test paper is just 10
Accuracy of 0 mg / dL or more, or less,
The test strip method is suitable for screening tests for diabetes.

On the other hand, there is also proposed a home health management apparatus in which a urine collecting unit and an analyzer are combined with a toilet bowl, which can measure various components in urine (Japanese Patent Laid-Open No. 2000-12).
6173).

[0008]

The urine sugar level is usually 10 to 10.
It is about 20 mg / dL, but when the blood glucose level exceeds the glucose excretion threshold of 180 mg / dL in the kidney, sugar in the blood overflows into the urine and appears, and the higher the blood glucose level, the higher the urine glucose level.
When diabetes develops, it may exceed 1000 mg / dL.

For the prediction of diabetes mellitus, usually 10
100 mg increase the chance of diabetes from 20 mg / dL
It is necessary to accurately measure a so-called low concentration region up to mg / dL. However, the test strip method has insufficient measurement accuracy, and it is difficult to perform the primary prevention using the test strip method because it is possible to discriminate 100 mg / dL or more.

It is considered that if a change in urinary sugar level between about 20 and 100 mg / dL can be used as an index for diabetes prevention, it is suitable as a simple measuring method at home, but there is no simple and highly accurate measuring method. However, there was not enough clinical data to be evaluated as a diabetes prevention index, and its value was never evaluated.

Although it may be possible to deal with the problem by improving the measurement accuracy of the test strip method, the measurement principle is difficult because urinary sugar is used as the measurement object, and the physical condition of the individual and the lighting and reading when visually reading the color tone change are also considered. Since the error due to time, the urine soaking time and the error due to the wiping method are large, the measurement accuracy is low, so that the low urinary sugar level cannot be measured accurately and cannot be used for the primary prevention of diabetes.

The apparatus described in Japanese Patent Laid-Open No. 2000-126137 described above can measure various components in urine, and although it is convenient by self-measurement, it is large for installation in each home.
It is expensive. Urine sugar is the most effective urinary component as an index for preventing lifestyle-related diseases, and its effectiveness other than urine sugar is low. It is not enough as a health management system focusing on diabetes prevention by measuring urine glucose.

When focusing on diabetes prevention by measuring urine sugar,
Rather than extracting valid data from random measurement data in daily life, it is more reliable to measure under certain measurement conditions, and it is not necessary to measure frequently as a diabetes prevention index. Since it is not there, it is far less likely to feel complicated. Also, by operating a simple and inexpensive measurement system and obtaining results, awareness of health management will be improved.

The present invention has been made in view of the above-mentioned problems, and the risk of diabetes can be easily controlled at home and individually by measuring the urinary sugar level in a low concentration range. The purpose is to provide a health care device to obtain.

[0015]

The health management apparatus of the present invention comprises a urine sugar measuring means for measuring a urine sugar value in a low concentration range, and a measurement for accumulating a urine sugar value measuring result by the urine sugar measuring means for a predetermined period. It is provided with a result accumulating means and a judging means for judging a risk of diabetes from the accumulated urine glucose measurement results.

As the urine sugar value measuring means, for example, a biosensor of the enzyme electrode method is used. The low-concentration measurement range of the urine sugar value is, for example, 0 to 100 mg / dL. The urine sugar measurement is carried out 1 to 3 hours after each meal, and the measurement is carried out at least for, for example, 3 months or more and accumulated.

The determination means for determining the risk of diabetes can obtain an average value for a certain period of time, a slope of a regression line, a comparison of distributions of measured values, or a combination thereof from the measurement results of urinary glucose. These results determine the risk of diabetes.

Further, the health management apparatus of the present invention comprises a urine sugar measuring means for measuring a urine sugar value in a low concentration range, a blood sugar level estimating means for estimating a blood sugar level from the measured urine sugar value, and the blood sugar level. From the estimated result accumulating means for accumulating the blood glucose level estimation result by the estimating means for a predetermined period and the accumulated blood glucose level estimation result,
And a determination means for determining the risk of diabetes.

[0019]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in more detail with reference to embodiments. As one embodiment of the present invention, a health care device for measuring a urinary sugar value in a low concentration range will be described.

First, the principle of adoption of the health management apparatus of this embodiment will be described. Generally, as is well known, urinary glucose has a glucose excretion threshold of about 170 in the kidney.
When a hyperglycemic condition of mg / dL or higher is reached, the sugar content above the threshold value is excreted from blood into urine, and as a result, urine sugar is detected.

A healthy person does not have a blood glucose level of 140 mg / dL or more even after eating, which tends to raise the blood glucose level, and has a low urinary glucose level of about 10 to 20 (mg / dL). On the other hand, diabetic patients are judged by whether or not their blood glucose exceeds 200 mg / dL at 2 hours after oral loading of 75 g of grape juice, but most diabetic patients have hyperglycemia after meals, although it depends on the content of the meal. In most cases, glucose exceeding the renal threshold is excreted, and as a result, urinary glucose becomes high.

Further, in the case of a patient in the boundary region (diabetes reserve army) located between a healthy person and a diabetic patient, the postprandial blood glucose level gradually rises as the glucose tolerance decreases and becomes closer to diabetes. The peak value of the price increase rises with the delay of appearance time (see FIG. 1).

As shown in FIG. 1, even before the onset of diabetes,
Blood glucose level temporarily began to exceed the glucose excretion threshold of the kidney about 1 hour after eating, and the value gradually increased, and the condition progressed to healthy people, borderline patients, and diabetic patients, leading to diabetes. Become.

This pre-diabetes development stage is carried out by grasping not the blood glucose level measurement but the urine glucose level measurement to carry out the primary prevention of diabetes and contribute to the simple prevention of diabetes and lifestyle-related diseases at home. It is a form of health management device.

FIGS. 2 to 4 show the results obtained by investigating the relationship between the postprandial blood glucose level and the urinary glucose level in healthy people and diabetic patients, as well as in patients in the border region. Renal glucose excretion threshold 170 mg /
It was confirmed that the urinary glucose level increased along with the blood glucose level around dL, as in the past (see FIG. 2).
However, an increase in urinary glucose was observed along with an increase in blood glucose even in a region where the urinary glucose was 100 mg / dL or less (a low concentration region) where details were unknown in the past (see FIG. 3), and the low value It is understood that the blood sugar level can be estimated by measuring the urine sugar level.

[0026] Furthermore, looking at the results of the diabetes determination, it was found that it is possible to capture people who are in the pre-boundary region stage due to a significant decrease in glucose tolerance, both in patients with border regions and in healthy subjects (see Fig. 4). ) Based on these results and confirmation, the health management device of the present embodiment obtains a powerful index for diabetes prevention and lifestyle improvement by measuring the postprandial urinary glucose level and grasping the trend thereof.

In the health care device of this embodiment, urine sugar is measured by the following procedure. The peak value of postprandial blood glucose before the onset of diabetes, which causes postprandial urinary glucose elevation effective as a preventive index, is
It is about 1 hour after eating, and it is important to grasp the excretion of blood sugar at this time. Therefore, as shown in FIG. 5, urine glucose is measured 2 hours after eating. For example, urine is excreted before and after meals based on meal time, and urine glucose measurement is aimed at 2 hours after meal. Also, refrain from eating and drinking as much as possible after eating, and do not eat or drink that particularly contains sugar. Furthermore, it is also necessary to avoid vigorous exercise, which is expected to have a large effect on glucose metabolism, and to avoid measurement during medication such as a cold.

Naturally, it is preferable that the content of the meal is the same as usual, and if possible, it is measured in a stress-free environment at home on a holiday. Regarding the measurement frequency, it suffices if the above conditions are met, and it is not necessary to be particular about the measurement interval.
A goal of measuring several times a month on a measurement weekend is sufficient.

FIG. 6 shows an example in which urine sugar was measured by the procedure shown in FIG. 5 and the measurement date and the result were recorded. The measurer makes a note after the measurement and records the measurement date and the result. Recording is not a heavy burden, but may be automatically stored in the device. When the blood pressure value is recorded daily, the measured urine sugar value may be additionally recorded from time to time.

From the recorded values of the measurement results, the trend of urinary glucose change can be grasped, and it can be used for prevention of diabetes and improvement of lifestyle. As an example of grasping the trend of urinary sugar change, changes in average values for a certain period are compared. Figure 6 is from January 1
FIG. 7 also shows the recorded values obtained by measuring the urinary sugar value several times each month until October, and FIG. 7 also shows the average values every 3 months and 5 months. FIG. 8 shows the relationship between the measured value and the urine sugar value, and the average value comparison every 3 months. Similarly, FIG. 9 shows the relationship between the measurement date and the urine sugar value and the average value comparison every 5 months. When comparing the average values every 3 months, the initial 3
Based on months, the average urine sugar level every three months thereafter shows an increase of 5.1% and then 28.9% in the illustrated example, and it can be determined that there is an overall increasing trend. . 5
Even in the case of every month, it shows an increase of 22.7%, which can be judged to be an increasing trend.

As another example of grasping the trend of urine sugar change,
You may compare the approximate curve slope of the urine sugar measurement value of a fixed period. FIG. 10 shows the measurement date from January to October, the measured value, the linear approximation formula every three months, and the linear approximation formula every five months. Further, FIG. 11, FIG. 12, and FIG. 13 show the number of days elapsed and the urinary sugar value every three months, and the linear approximation formula, respectively. Further, FIGS. 14 and 15 show the number of days elapsed, the urine sugar value, and the first-order approximation formula every 5 months, respectively.
In the example shown here, when comparing the slopes every 3 months, the increase / decrease / increase is repeated every 3 months, and it is recognized that there is a slight increase tendency in the latter half, but in the case of every 5 months, it increases / decreases.
It shows an increase, and it can be judged that the overall increase trend and the latter half have a stronger increase trend.

Next, FIG. 16 shows the configuration of a urine sugar measuring device used as the health care device according to the embodiment. This urine sugar measuring device comprises a measuring device main body 1, a sensor part 2 and a storage case 3, and the sensor part 2 is attached to the measuring device main body 1 to provide a usable urine sugar measuring device. This sensor unit 2
The measuring device main body 1 in which the binarization is performed is stored in the storage case 3.

The measuring instrument body 1 includes a storage case detector 4 and
The control unit 5, the sensor drive unit 6, the sensor detection unit 7, the timer unit 8, the storage unit 9, the display unit 10, and the buzzer 11
And a transmission / reception unit 12 and a power supply unit 13. The storage case detector 4 detects whether or not the measuring device body 1 is stored in the storage case 3. The sensor driving unit 6 drives the sensor unit 2. The sensor detection unit 7 detects whether or not the sensor unit 2 is attached, and takes in a measurement signal from the sensor unit 2. The timer unit 8 regulates a set time for processing. The storage unit 9 stores the measured value, the average value, the slope of the first-order approximation formula, and the like. It also stores other data. The display unit 10 and the buzzer 11 output operation instructions, output data, and the like. The transmission / reception unit 12 transmits measurement data and the like to the center device and receives data from the center device. Control unit 5
Controls a series of measurement processes.

Using this urine sugar measuring instrument, the urine sugar measuring process is executed as shown in the flow chart of FIG. When starting the measurement, first, the measuring instrument body 1 is taken out from the storage case 3 (step ST1), and it is determined whether or not the measurement preparation is completed (step ST2). After confirming the display on the display unit 10 or the measurement by the sound of the buzzer 11, the urine is measured by the sensor unit 2.
Take a few seconds to dent the tip. Further, the sensor unit 2 is immersed in the collected urine to measure urine sugar (step ST
3). When the measurement is completed (step ST4), the buzzer sound at the end of the measurement or the measurement result display is confirmed and the measurement result is recorded (step ST5). Next, the sensor unit 2 is washed with tap water (step ST6), and the buzzer sound of the washing end or the storage instruction display is confirmed (step ST6).
7), save in storage case 3 (step ST8).

Next, referring to the flow chart shown in FIG.
The operation processing of the urine sugar measuring instrument will be described. The measuring device main body 1 is stored in the storage case 3, the storage case detection unit 4 detects the storage case 3 during the storage, and is in a standby state in the storage case (step ST11). When the measurer removes the measuring device main body 1 from the storage case 3 for measurement, the storage case detection unit 4 detects that the measurement device body 1 has been taken out, and the step S
The determination of “take out” of T12 is YES, and in response to this, the power supply of the entire measuring instrument body 1 is turned on (step S
T13), and when the automatic preparation in the measuring instrument body 1 is completed, the fact is displayed on the display unit 10 (step ST1).
Along with 4), a buzzer sound indicating that effect, that is, preparation is sounded (step ST15).

Then, when the measurement is started by immersing the sensor unit 2 in urine or the like (step ST16), the buzzer 11 emits a sound indicating that the measurement is in progress (step ST
17), measurement data processing is performed (step ST18).
Next, when the measurement is completed (step ST19), the buzzer 11 outputs a sound indicating the completion of the measurement (step S19).
T20), the measurement result is displayed on the display unit 10 (step ST21). Further, the sensor cleaning instruction is displayed on the display unit 10 (steps ST22 and ST23).

When it is confirmed that the cleaning has been performed (step ST24), a sound indicating the completion of cleaning is output by the buzzer 11 (step ST25), and an instruction to "store the main body" is displayed on the display unit 10 (step). ST26). Then, it is determined whether or not the measuring device body 1 is stored in the storage case 3 based on the presence or absence of the detection signal of the storage case detection unit 4 (step ST27). When the measurement is normally completed, the transmission / reception unit 12 transmits the measurement result to the center device or the like (step ST28). When transmission is completed, step S
The process returns to T11 (step ST29).

FIG. 19 is an external view of a urine sugar measuring instrument. In the urine sugar measuring instrument 21, a sensor 23 is detachably attached to a measuring instrument main body 22, and a display unit (LCD) for displaying measured values (urine sugar, etc.) and various instructions on the surface side of the measuring instrument main body 22.
24 is provided, and the battery cover 2 is attached to the head of the measuring device main body 22.
5 is detachably attached. Sensor 23
A detection portion 23a for detecting urine is opened at the tip of the
Urine is attached to the detection unit 23a. A calibration switch 26 for performing calibration is provided on the back side of the measuring device body 2.

The measuring device main body 22 has a drip-proof structure including a sensor mounting part at the front end and a power supply part at the rear end other than the display part, and liquid enters inside when measuring urine sugar and cleaning the sensor part. To prevent that.

The sensor 23 is waterproofly attached to the tip of the main body 22 with a dedicated fixture 27 and an internal O-ring, and can be used repeatedly a plurality of times. Dedicated fixture 27 for the main body
Is integrated, and is replaced together with the dedicated fixture 27 at the time of replacement after multiple uses.

When the urine sugar measuring instrument 21 is not used, it needs to be preserved in a special preservation solution, and a special storage case including the main body as shown in FIG. 20 is prepared and stored. FIG. 20 is an external perspective view of the storage case, and FIG. 21 is a cross-sectional view in which the wall mounting plate is attached to the back side.

Not only can this storage case be placed on the floor of the toilet, but it can also be attached to the wall surface using the wall mounting attachment plate described below. This storage case is the case body 30
In addition, a urine sugar measuring instrument storage port (measuring device storing section) 32 for accommodating the urine sugar measuring instrument with the sensor side facing downward, and in an upright state,
A storage liquid container mounting port (storage liquid container storage portion) 34 that is arranged at the bottom of the case body 30 and detachably stores a storage liquid container that stores the storage liquid of the sensor 23 of the urine sugar measuring instrument 21,
A body cover 35 that is attached to the case body 30 so as to be openable and closable, and covers the urine sugar measuring instrument 21 portion and the like that appears from the storage opening 32 while the urine sugar measuring instrument 21 is stored in the storage opening 32.
The urine sugar measuring instrument 21 and the temporary storage cup storing portion (the measuring instrument temporary storage portion, which is the inner space of the main body cover) 38 for detachably storing the temporary storage cup 36 for temporarily placing the urine sugar measuring instrument 1 A calibration liquid cup mounting port (calibration liquid container storage portion) 40 that detachably stores a calibration liquid cup (calibration liquid container) that stores the calibration liquid of the sensor 23 is provided.

A cover 42 that closes the storage port 32 when the urine sugar measuring instrument 21 is taken out from the storage port 32 is attached to the case body 30 so as to be openable and closable. The case body 30 has holes (large hole 46a [see FIG. 21] and small hole 46b) for wall surface attachment on the back side (back plate 44).
On the front side of the bottom of the case main body 30, a confirmation window 48 for visually recognizing the preservation liquid in the preservation liquid container is provided so that stains and remaining amount of the preservation liquid can be easily confirmed. The storage solution (also called a buffer solution) is the sensor 23 of the urine sugar measuring instrument 21.
Is kept in a wet state, and PH and ion concentration are kept constant. For example, phosphate is used.

Further, each part will be described. The storage liquid container 70 is arranged at the storage liquid container mounting port 34 of the storage case. The storage container 70 has a lid 71, and the lid 71 is removed to set the storage liquid container 70 in the attachment port 34. Then, when the urine sugar measuring instrument 21 is stored in the storage port 32, the sensor 23 (detection unit 23a) is immersed in the storage liquid in the storage liquid container 70, and the display unit 24 is exposed from the storage port 32. It has become.

When the lid 71 of the storage solution container 70 is removed, a packing 72 made of rubber, for example, is fitted into its opening. The packing 72 improves the airtightness between the sensor 23 of the urine sugar measuring instrument 21 and the opening of the preservative solution container 70, and dust is stored in the preservative solution container 70 with the urine sugar measuring instrument 21 housed in the storage case. Etc. can be prevented from entering and the preservation solution can be kept hygienic. Moreover, the appropriate elasticity of the packing 72 increases the stability of the urine sugar measuring instrument 21.

On the back surface, a wall-mounting mounting plate 80 used when mounting the storage case on the wall surface is provided.

From the urine measuring instrument storage port 22 for accommodating the urine sugar measuring instrument 21, a tubular portion 50 extends downward, and the tubular portion 5
By 0, the urine sugar measuring instrument 21 is supported in a vertically standing state. The circular opening below the tubular portion 50 is narrowed, and the base end of the sensor 23 engages with this circular opening, so that the detection portion 23a of the sensor 23 is immersed in the preservation liquid in the preservation liquid container 70. At the same time, the urine sugar measuring instrument 21 is positioned so that the display portion 24 is located above the tubular portion 50. A magnet is embedded in the inner wall surface of the tubular portion 50 so as to be exposed. The magnet is for turning on / off the reed switch built in the urine sugar measuring instrument 21, and the storage port 32
It is positioned so as to face the reed switch when the urinary sugar measuring instrument 21 is housed therein. Here, the reed switch is turned off when the urine sugar measuring instrument 21 is stored in the storage port 32, and is turned on when the urine sugar measuring instrument 21 is taken out.
Is set to be

A weight 52 is provided at the bottom of the case body 30 (below the preservation liquid container 70). This weight 52
Is for lowering the center of gravity of the tall case body 30 to increase stability when placed on the floor and to prevent falls, and is made of metal such as iron or lead, or plastic. A non-metal material such as a metal material may be used as long as it is relatively heavy for its volume.

The body cover 35 is openably and closably attached by a shaft support portion 54 provided on the case body 30.

The temporary cup 36 is removably attached to the inside of the body cover 35. In this embodiment, the temporary cup 36 has a pair of support pieces 56 extending 180 degrees in opposite directions from its side surfaces. On the other hand, inside the main body cover 35, the pair of support pieces 5 of the temporary storage cup 36
6, a pair of linear protrusions 58 that engage with each other are formed, and a pair of contact pieces 60 that contact the side surface of the temporary storage cup 36 are formed. Therefore, in order to mount the temporary storage cup 36 inside the main body cover 35, the temporary storage cup 36 is lowered along the contact piece 60 with the main body cover 35 open, and the support piece 56 abuts on the protrusion 58. Up to this, the support piece 56 may be engaged with the protrusion 58. By doing so, the temporary storage cup 36 is attached to the main body cover 3
5 is set and the main body cover 35 is closed, as shown in FIG. 20, and when the main body cover 35 is opened, the opening of the temporary storage cup 36 faces upward, and the sensor 23 side of the urine sugar measuring instrument 21 is inserted. By doing so, the urine sugar measuring instrument 21 can be temporarily placed. To remove the temporary storage cup 36, the main body cover 35 may be opened and pulled out upward.

A cylindrical portion 64 having a smaller diameter and shorter than the cylindrical portion 50 extends downward from the calibration liquid cup mounting port 40 for accommodating the calibration liquid cup 62. Is supported. When the urine sugar measuring instrument 21 is calibrated, the calibration solution may be put in the calibration solution cup 62 and the sensor 23 of the urine sugar measuring instrument 21 may be inserted. Of course, the calibration liquid cup 62 can be easily attached and detached.

A cover 42 for opening and closing the urine meter storage port 32
Is attached so as to be openable and closable by a shaft supporting portion 66 provided on the case body 30.

FIG. 22 shows the display contents of the display. The display content shows the measurement procedure, the measurement result, and the measurement result determination. As for the measurement procedure, “Measurement”, which indicates the measurement ready state after the preparation for measurement, “Washing” that instructs the end of measurement and sensor cleaning, and “Storage” that instructs the end of cleaning and storage of the sensor in the storage container Light.

The measurement result is displayed numerically in units of 1 mg / dL, and the judgment result divided into three stages according to the measurement result is also indicated by lighting of a triangular icon corresponding to the judgment result. Figure 2
3 shows an example of measurement result display. In this display example, the measurement result is "128 mg / dL", "cleaning" is instructed to wash the sensor part at the end of the measurement, and the measurement result is 128 mg / dL according to the determination level, "the urine sugar is slightly detected" is instructed. A triangle icon is displayed in the middle of the right edge. The judgment result is
For example, it is determined according to the division level of the measurement result shown in FIG.

FIG. 25 is a block diagram showing the configuration of a health management system having a communication function. A urine sugar measuring device 100 provided in a home and a data collecting / processing device 200 provided in a health care organization are connected via a network 300. The urine sugar measuring device 100 includes a transmitting / receiving unit 101, a control unit 102, and a temporary storage unit 103. Further, the data collection / processing machine 200 includes a transmission / reception unit 201, a large-capacity storage unit 202, and a data processing result 203. This health management system can automatically send urine measurement results to the outside using a network, receive measurement result judgments and life improvement instructions and advice, reduce the burden on the measurer, and provide quick and accurate results. There are many advantages such as judgments, feedback to individuals, and reliable data storage management.

As the network 300, a telephone line,
A dedicated line, the Internet, and the like are conceivable. For transmission, it may be necessary to temporarily install a repeater in the home to support various networks. The measurement result from each measuring device is temporarily stored in the data collection / processing device 200 of the health care institution in an individual and time series. Thereafter, data processing such as trend grasping is performed, and the result is additionally stored as a data processing result 203. Further, the advice corresponding to the result is output, returned through the network 300, or returned as a document.

FIG. 2 shows the processing operation of this health management system.
6, and the flow charts shown in FIGS. 27 and 28 will be described. First, reception of data is awaited (step ST31) until data reception starts (step ST31).
32) The data from the urine sugar measuring instrument is received until the reception is completed (step ST33). When the reception is completed (step ST34), the reception completion is transmitted to the urine glucose meter (step ST35). Then, the received data, that is, the personal name, time, and measurement result are stored (step ST3).
6). Then, data processing such as trend processing is performed (step ST37). Next, it is determined whether or not it is in an abnormal state (step ST38). If it is in an abnormal state, the abnormality is urgently notified (step ST39), and if it is not in an abnormal state, the data processing result is periodically notified. The process of determining whether or not the state is abnormal will be described below.

The determination of the abnormal state in step ST38 starts with the data processing every three months in step ST41 shown in FIG. It is determined whether or not the urine sugar value is 100 mg / dL twice or more based on the data for 3 months (step ST42). If 100 mg / dL is twice or more, diabetes is likely, and the urine glucose meter is informed immediately of this (step ST43). If not more than twice
Next, it is determined whether the average value for 3 months is 30 or less (step ST44). When the average value is 30 or less, the risk is low, and the data processing result is notified (step ST
48 [step ST40]).

If the average value for three months is not 30 or less in step ST44, it is determined whether the average value is 30 to 50 (step ST45). Average value is 30-50
If so, “increased risk” and some improvement in lifestyle are necessary, so the data processing result is notified (step ST4).
7). If the average value is not 30 to 50, the average value is more than 50, and there is a large risk, and there is an urgent need to improve lifestyle habits, and the fact is urgently notified (step ST46).

In the above process, it is determined whether or not the state is above based on the average value of the urine sugar value every three months, but it may be determined from the slope of the linear approximation formula.

In this case, first, as shown in FIG.
Data processing is performed every three months to obtain the slope of the approximate straight line (step ST51). Next, the urine sugar level is 100 mg / d
If L or more, it is determined whether or not it is twice or more (step ST52). If there are two or more times, the possibility of diabetes is high, and an urgent notification is given (step ST53). The processing up to this point is similar to steps ST41 to ST43 described above.

When the urine sugar value is not more than 100 mg / dL twice or more, it is determined whether or not the slope of the approximate straight line every three months is 0.05 or less (step ST54). When the inclination is 0.05 or less, the risk is low and the data processing result is notified (step ST58 [step ST
40]).

In step ST54, if the slope of the approximate straight line for 3 months is not less than 0.05, the slope is 0.
It is determined whether it is 05 to 0.15 (step ST55).
If the slope is 0.05 to 0.15, it means “risk increase” and some improvement in lifestyle is uncertain, so the data processing result is notified (step ST57). Inclination is 0.05 ~
If it is not 0.15, it is more than 0.15, which means "high risk", and there is an urgent need to improve lifestyle habits, and the fact is urgently notified (step ST56).

In the above embodiment, the urinary sugar level in the low concentration range is measured, the urine sugar level measurement results are accumulated for a predetermined period, and the accumulated urine sugar level measurement results indicate the risk of diabetes. Although it is determined, as another embodiment of the present invention, the urine sugar value in a low concentration range is measured, the blood sugar level is estimated from the measured urine sugar value, and the obtained blood sugar level estimation result is accumulated for a predetermined period. However, the risk of diabetes may be judged from the accumulated blood glucose level estimation result.

[0065]

According to the present invention, the urine sugar measuring means for measuring the urine sugar value in the low concentration range, and the measurement result accumulating means for accumulating the urine sugar value measurement result by the urine sugar measuring means for a predetermined period, From the accumulated urine glucose measurement results, it is equipped with a judgment means for judging the risk of diabetes, so by measuring urine sugar using an enzyme electrode biosensor, it is clear that urine sugar is detected from the diabetic stage. It becomes possible to perform preventive measurement that captures the previous boundary area (or the stage called the diabetes reserve army) and the stage where glucose intolerance is significant even in healthy people, and the risk management for diabetes can be easily performed at home. Furthermore, awareness is given to improve lifestyle habits through the habit of checking urine sugar, an environment where behavioral changes are easily realized can be secured, and diabetes and other lifestyle habits can be widely prevented.

[Brief description of drawings]

FIG. 1 is a diagram showing a relationship between an elapsed time after glucose loading and a blood glucose level.

FIG. 2 is a diagram showing a relationship between a postprandial blood glucose level and a postprandial urinary glucose level in healthy people and diabetic patients, as well as in boundary area patients.

FIG. 3 is a graph showing the relationship between postprandial blood glucose level and postprandial urine glucose level.

FIG. 4 is a diagram showing a relationship between a blood glucose level after 60 minutes of glucose load and a urine glucose level after 120 minutes of glucose load in healthy people and diabetic patients as well as in patients in the boundary region.

FIG. 5 is a diagram illustrating a urine sugar measurement procedure.

FIG. 6 is a diagram showing an example of recording the measurement date and urine sugar measurement value in October.

FIG. 7 is a diagram showing measurement days, urine sugar measurement values, and average values every 3 months and 5 months in the same month.

FIG. 8 is a diagram showing a comparative graph of urine sugar measurement values and average values every 3 months.

FIG. 9 is a diagram showing a comparison graph of urine sugar measurement values and average values every 5 months.

FIG. 10 is a diagram showing measurement days, urine sugar measurement values, and inclination examples of first-order approximation every three months and every five months during the same October.

FIG. 11 is a diagram showing elapsed days, urine sugar values, and their approximate expressions in January, February, and March of the measurement example shown in FIG.

FIG. 12 is a diagram showing elapsed days, urinary sugar values, and their approximate expressions in April, May, and June of the measurement example shown in FIG. 10.

13 is a diagram showing the number of days elapsed, the urinary sugar level in July, August and September of the measurement example shown in FIG. 10 and its approximate expression.

14 is a diagram showing the number of days elapsed from January to May and the urine sugar value and its approximate expression in the measurement example shown in FIG.

15 is a diagram showing the number of days elapsed and the urinary sugar level in June to October of the measurement example shown in FIG. 10 and its approximate expression.

FIG. 16 is a block diagram showing a configuration of a urine sugar measuring device used as an embodiment health management device.

FIG. 17 is a flowchart showing a measurement processing procedure when urinary sugar is measured using the same urine sugar measuring device.

FIG. 18 is a flowchart for explaining an operation process of the urine sugar measuring device.

FIG. 19 is an external perspective view showing a measuring device body of the urine sugar measuring device.

FIG. 20 is an external perspective view of a storage case of the urine sugar measuring device.

FIG. 21 is a cross-sectional view of a storage case of the urine sugar measuring instrument when the measuring instrument main body is stored.

FIG. 22 is a diagram showing all display functions of the measuring device main body of the urine sugar measuring device.

FIG. 23 is a diagram showing a measurement display example of the measuring device main body of the urine sugar measuring device.

FIG. 24 is a diagram showing a relationship between determination contents and measurement result values in the measuring device body of the same urine sugar measuring device.

FIG. 25 is a block diagram showing the configuration of a health management system with a communication function.

FIG. 26 is a flowchart for explaining the process of the data collection / management device in the health management system.

FIG. 27 is a flowchart showing in detail the processing for determining an abnormal state of processing in the data collection / management apparatus.

FIG. 28 is a flowchart showing another example of the abnormal state determination process of the process in the data collection / management machine.

[Explanation of symbols]

100 urine sugar meter 101 Transmitter / receiver of urine glucose meter 102 control unit 103 temporary storage 200 data collection and processing machines 201 Transmitter / receiver of data collection / processor 202 Large-capacity recording section 203 Data processing result 300 networks

Front page continuation (51) Int.Cl. ⁷ Identification code FI theme code (reference) G01N 27/327 G01N 33/66 A 27/416 A61B 5/14 310 33/483 G01N 27/46 338 33/66 27 / 30 353Z (72) Inventor Yusaku Sakoda 801 Horikawa Higashiiri Minamifudodocho, Shiomokoji, Shimogyo-ku, Kyoto Inside OMRON Life Science Laboratory Co., Ltd. (72) Keiko Nakamura 1-5-45 Yushima, Bunkyo-ku, Tokyo Medical and Dental University (72) Inventor Kento Takano 1-5-45 Yushima, Bunkyo-ku, Tokyo F-term in Tokyo Medical and Dental University (reference) 2G045 AA16 AA36 BB14 CB03 DA31 FB05 JA01 JA20 4C038 DD00 KK10 KL05 KL09 KM00 KX02 KY04

Claims (10)

[Claims] 1. A urine sugar measuring means for measuring a urine sugar value in a low concentration range, a measurement result accumulating means for accumulating a urine sugar value measurement result by the urine sugar measuring means for a predetermined period, and the accumulated urine sugar value. A health management device comprising: a determination unit that determines the risk of diabetes based on the measurement result. 2. The low concentration measurement range is 0 to 100 mg / dL.
The health care device according to claim 1, wherein 3. The health care device according to claim 1, wherein the urine sugar measuring means uses an enzyme electrode method. 4. The health care device according to claim 1, wherein the urine sugar measurement is performed 1 to 3 hours after each meal, and the measurement is performed for at least 3 months or more and accumulated. 5. The determination means for determining the risk of diabetes mellitus obtains an average value for a certain period from the measurement result of urine sugar level, and determines the risk of diabetes mellitus from the average value. Health management device described. 6. The determination means for determining the risk of diabetes mellitus determines the slope of a regression line from the urine glucose measurement result, and determines the risk of diabetes from the slope of the regression line. The health management device according to 1. 7. A judging means for judging the risk of diabetes, comparing the distribution state of the measured values from the urine glucose measurement results,
The health management device according to claim 1, wherein the risk of diabetes is determined based on the comparison result. 8. The determining means for determining the risk of diabetes mellitus obtains an average value for a certain period of time, a slope of a regression line, and a distribution state of the measured values from the urine glucose measurement results, and at least two of these are obtained. The health management device according to claim 1, wherein the risk of diabetes is determined from the result of the combination of two. 9. The determination means for determining the risk of diabetes, based on the urine glucose measurement result, the average value for a certain period, the slope of the regression line, or the comparison of the distribution state of the measurement values, or a combination thereof. If the low urinary sugar level is increasing,
The health management device according to claim 1, wherein it is determined that the risk of diabetes is increasing. 10. A urine sugar measuring means for measuring a urinary sugar level in a low concentration range, a blood sugar level estimating means for estimating a blood sugar level from the measured urine sugar level, and a blood sugar level estimating result by the blood sugar level estimating means. A health management apparatus comprising: an estimated result accumulating means for accumulating for a predetermined period; and a judging means for judging a risk of diabetes from the accumulated blood sugar level estimation results.