JP2003113072A - Face scrub - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a face scrub that is made of silk with high class appearance, has both functions of making beautiful skin and of scrubing keratin at a proper level, gives the usability that can really perceive the pleasant use of physiologically active components visually or on any place where the scrub is used with high safety and excellent biodegradability. SOLUTION: This face scrub is made of silk fibroin wherein the average particle size of the scrub is adjusted to the range of 150-2000 μm.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a scrubbing agent comprising silk fibroin, which is blended in a cleansing agent such as a facial cleanser, a hand washing agent, and a body soap, a cosmetic agent such as a massage agent, and a skin scraping tool, and which is suitable. The excellent feeling of use and the feeling of particles due to its excellent disintegration can be confirmed through visual and tactile sensations, and the natural moisturizing factor (NMF) that forms silk fibroin
The present invention relates to a scrubbing agent made of silk fibroin, which is expected to have a skin beautifying effect brought about by an amino acid polymer containing a high proportion of constituent amino acids, and which can also contain a physiologically active ingredient, and a cosmetic and a skin abrasion device containing the same.

[0002]

2. Description of the Related Art Silk fibroin is a protein in which amino acids are linked in the order of several thousand by peptide bonds. This silk protein retains water in the stratum corneum such as skin
It contains a high percentage of the amino acids that make up the natural moisturizing factor (NMF), which is extremely important for regulating and maintaining the flexibility of the skin. Conventionally, silk proteins have been used in various forms such as aqueous solutions and powders, because the amino acid polymer can be expected to have beautiful skin effects and health effects. Among these silk fibroins, it is well known that a powder having a particle size adjusted to about 1 μm to 50 μm exists. Such a powder made of silk fibroin is used for various purposes such as cosmetics and food because of its unique smooth texture and effect. However, since the particle size is too small, it is difficult to use it as a scrubbing agent to be used while visually observing or touching its presence and recognizing the effect.

A scrubbing agent is a typical granular material that can be visually perceived or sensed as a tactile sensation. For example, a scrubbing agent is mixed with a cosmetic such as a cleansing agent or a massage agent, and the physical detergency of the scrub effectively removes waste products, sebum, keratin, and dust adhering to the skin surface. However, it is well known that the stimulation produces a massage effect on the skin. Although not a scrub, as a tool for removing keratin, as disclosed in Japanese Patent Laid-Open No. 2001-105331, a vegetable abrasive particle is used as a core and a silk component is added to this to improve skin rubbing function and beautiful skin. Effective skin scraping tools are also known.

Generally, a scrubbing agent has been used by a method of blending a powder or granules of an inorganic substance, an organic substance, or a mixture thereof into a cleaning agent or a massage agent without processing into a proper particle size. Typical examples include natural plant materials such as apricot kernels, peach kernels, and corn cobs, inorganic materials such as crystalline sodium chloride and calcium carbonate, amorphous silicon dioxide, and polyethylene granules. A molecular material, a spherical or non-spherical synthetic plant material composed of cellulose particles, and the like are used.

The above-mentioned natural plant-based material has the great merit that it is a literally natural material and has biodegradability after use and is environmentally friendly. However, the material itself has high hardness and can be obtained by pulverization. Therefore, it is difficult to keep the shape constant, and there are many angular portions.
Therefore, there is a risk of damaging the skin when these are mixed with cosmetics such as detergents and used. For this reason, it is necessary to take measures such as rounding the scrub shape by a method such as polishing, but this is often technically difficult.

With the above-mentioned inorganic material, the size and shape of the scrub particles can be adjusted appropriately, but the hardness of the scrub particles is large and the irritation to the skin or the like tends to be too strong. In addition, if a large amount of sewage is washed and then washed, the sewage adheres to pipes and the like, often causing scale formation.

Further, with the above-mentioned polymeric materials, it is possible to appropriately adjust the size and shape of the scrub particles as in the case of the inorganic materials, but in both cases, there is almost no water absorption or hydrophilicity and irritation is caused. Tends to be too strong. Also, after washing
If a large amount is poured into sewage, it is poor in biodegradability and remains in the environment forever, which is not preferable.

[0008] Further, the material of cellulosic particles has the advantages that the shape and size of the scrub particles can be adjusted, the water absorption and hydrophilicity are excellent, and the biodegradability is good.
From the viewpoint of skin beautifying effect, it was poor in functionality, and it was difficult to manufacture a product full of high quality.

Further, Japanese Patent Application Laid-Open No. 2001-105331 discloses a method of mixing vegetable abrasive particles and a silk component into a skin abrasion tool. This is because pumice stones with high hardness, such as ordinary natural stones and silicon, have too strong an effect to scrape off the stratum corneum on the skin surface, and the user feels pain when rubbing the elbows or knees other than the heel, or the skin is damaged. Compared with the possibility of damage, it has a small hardness, so a moderate shaving effect can be obtained, and it is suitable for removing the old stratum corneum such as elbows and knees. However, only by mixing such plant-based abrasive particles and silk components, the skin is less irritating, but on the other hand, the effect of exfoliating the dead skin is poor, and it is difficult to be visually and sensory grasped. In addition, it is also difficult to stably mix a physiologically active ingredient or an active ingredient, which is generally used as a raw material for cosmetics and has an effect on beautiful skin, at a high rate. Therefore, there has been a demand for the development of a skin scraping tool that has both the skin-beautifying effect and the function to remove keratin, and that can visually and sensibly sense such physiologically active ingredients.

[0010]

SUMMARY OF THE INVENTION The present invention has been made in view of these problems, and an object thereof is to provide a scrubbing agent comprising silk fibroin which is excellent in usability, visual appeal and functionality.

[0011]

The above object is achieved by a scrubbing agent which is characterized by comprising silk fibroin and having an average particle size in the range of 150 to 2000 μm.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention is described in detail below.

The present invention is a scrubbing agent comprising silk fibroin particles. Silk fibroin according to the present invention,
It refers to the main protein component of silk thread made by silkworms. The silk fibroin raw material used for producing the scrubbing agent comprising the silk fibroin particles according to the present invention may be eyebrows, raw silk, eyebrows scraps, raw silk scraps, screws, fried cotton, silk cloth scraps, burettes, etc., if necessary according to a conventional method. In the presence of activator,
It is possible to use dried ones by removing sericin in warm water or in warm water in the presence of enzyme, but not limited to these, and any commercially available silk fibroin raw material can be used. .

The scrubbing agent comprising silk fibroin in the present invention means that silk fibroin has an average particle size of 150 to 200.
It refers to particles formed in the range of 0 μm. The scrubbing agent can be obtained by recrystallizing a silk fibroin colloidal solution.

The method for producing the scrubbing agent in the present invention will be described below.

The silk fibroin colloidal solution used for producing the scrubbing agent comprising silk fibroin in the present invention means a solution in which silk fibroin molecules are colloidally dispersed in an aqueous solvent, or a state in which the silk fibroin molecules are partially dissolved. A solution in which dispersed states are mixed. The method for producing the silk fibroin colloidal solution is not particularly limited, but one example is shown below.

The silk fibroin colloidal solution used in the present invention is obtained by dissolving the above-mentioned sericin-free silk fibroin raw material in a high-concentration salt aqueous solution and then dialysis desalting. The dissolved salt is selected from the group consisting of copper-ethylenediamine, copper hydroxide-ammonia, copper hydroxide-alkali-glycerin, lithium bromide, calcium or magnesium or zinc hydrochloride or nitrate or thiocyanate, and sodium thiocyanate. At least one selected from the above is included. The salt concentration of these aqueous solutions varies depending on the type of solvent used, temperature, etc., but is usually preferably 20 to 40% (mass). Dialysis desalting is performed using a dialyzer having a multilayer membrane structure or a hollow fiber converging structure. At this time, it is preferable to adjust the silk fibroin concentration in the silk fibroin colloid solution after dialysis desalting to 2 to 20% (mass) in order to recrystallize the silk fiber without difficulty.

The method of recrystallizing the scrubbing agent comprising silk fibroin particles from the silk fibroin colloidal solution of the present invention is not particularly limited, but addition of a coagulating salt, air blowing, isoelectric point coagulation, ultrasonic wave, One or more kinds of physical or chemical actions such as high shearing force are uniformly applied to the silk fibroin colloidal solution. The production process of silk fibroin particles is as follows. By giving the action to the silk fibroin colloidal solution, first, the recrystallization of silk fibroin in the solution starts in a very micro state, and the recrystallization amount increases with time, so that the solution Rather than recrystallizing alone, the recrystallized silk fibroin that has been recrystallized first serves as the nucleus for better recrystallization on this surface, and eventually grows into giant silk fibroin particles.

The thus obtained silk fibroin particles can be used as they are in an aqueous medium by adjusting the (particle: aqueous medium) ratio as necessary,
There is no problem in directly blending it into the prescription system. In addition, the silk fibroin particles produced in this aqueous medium may be washed, dehydrated, crushed, sized, and dried if necessary. The washing is performed when it is necessary to remove the drug by recrystallizing the drug in the recrystallization step. The method can be appropriately selected according to a conventional method such as a water replacement method by decantation, a filter pressing method, a centrifugal separator spraying method. When it is necessary to continue dehydration, it is preferable to use a filter press or a centrifuge because the process will not take much labor.
The crushing is carried out in the sense that when the silk fibroin particles are adhered to each other by an external force during the dehydration to form a cake-like shape, they are broken. Since the individually recrystallized materials are only brought into intimate contact with each other only by an external force, they can be disintegrated by applying a slight force. The sieving has a sieving function, for example, a vibrating screen is used, and the particles are aligned to a predetermined size. It is implemented to improve the efficiency of the process. Drying is performed by a known drying method such as tray-type hot air drying, fluidized bed-type drying, reduced pressure drying, and freeze-drying.

The shape of the silk fibroin particles of the present invention is generally obtained as a sphere or an aggregate of spheres. The average particle size of the scrubbing agent comprising the silk fibroin particles of the present invention is 150 to 2000 μm.
Within this range, both usability and visual appeal can be satisfied. If it deviates from this range, either the usability as a scrubbing agent or the visual appeal is impaired, which is not preferable.

The average particle size and physical properties of the scrubbing agent comprising the silk fibroin particles of the present invention vary greatly depending on the drying method. Specifically, when dried by heating, light brown to light yellow hard granular silk fibroin is obtained. On the other hand, when dried by a method such as freeze-drying, granular silk fibroin with a whitish, porous and soft feel is obtained. Further, both of them are hydrated when immersed in an aqueous solvent to obtain elastic silk fibroin. For this reason, considering the dosage form and purpose of the cosmetics to be blended,
It is important to select the drying method.

The scrubbing agent comprising silk fibroin of the present invention may contain a physiologically active ingredient, an active ingredient and a coloring ingredient. The inclusion here means that those components are aggregated by the scrubbing agent comprising the silk fibroin of the present invention,
It refers to the state of being covered and covered. Specifically, when the silk fibroin particles according to the present invention are recrystallized from a silk fibroin colloidal solution, a step of mixing the fibroin colloidal solution with a physiologically active component or a coloring component to recrystallize and grow the silk fibroin particles. At the same time, the physiologically active ingredient and the coloring ingredient are combined. More specifically, according to the properties of the component to be complexed, the compound is water-soluble according to JP-B-60-13672, and in the case of a water-insoluble solid such as a pigment, JP-B-57-11577. According to the publication, in the case of an oily liquid, it can be carried out by the methods described in Japanese Patent Publication No. 5-79260 and Japanese Patent Laid-Open No. 4-193812, but the invention is not limited thereto.

The physiologically active ingredient which can be included in the scrub agent comprising silk fibroin of the present invention refers to a substance which gives some physiological activity to the skin when applied to the skin. For example, whitening ingredients, anti-inflammatory agents, anti-aging agents, UV protection agents, slimming agents, tightening agents, antioxidants, moisturizers, blood circulation promoters, antibacterial agents, bactericides, drying agents, cooling agents, warming agents. , Vitamins, amino acids, wound healing promoters, stimulants, analgesics, cell activating agents, plant extracts and the like.

Examples of these components include, for example, ashitaba extract, avocado extract, armature extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract, fennel extract, turmeric extract, oolong tea extract, agets. Extract, Chinese cabbage leaf extract, sardine extract, psyllium extract, scutellaria extract, barley extract, St. John's wort extract, sardine extract, Dutch mustard extract, orange extract, seawater dried product, seaweed extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk , Chamomile extract, carrot extract, wormwood extract, licorice extract, karkade extract, oyster extract, kiwi extract, kina extract, cucumber extract, guanosine,
Gardenia extract, Kumazasa extract, Clara extract, Walnut extract, Grapefruit extract, Clematis extract, Chlorella extract, Mulberry extract, Gentian extract,
Black tea extract, yeast extract, burdock extract, rice bran fermented extract, rice germ oil, comfrey extract, collagen,
Bilberry extract, Cycin extract, Psycho extract, Cai Tai extract, Salvia extract, Sorbour extract, Sasa extract, Hawthorn extract, Hawthorn extract, Shiitake extract, Dio extract, Sikon extract, Perilla extract, Shinanoki extract, Shimotsukisou extract, Peony extract, Shobu root extract , Birch extract, horsetail extract, Ivy extract, Hawthorn extract,
Sambucus nigra extract, yarrow extract, mint extract, sage extract, mallow extract, senkyu extract, senburi extract, soybean extract, turmeric extract, thyme extract, tea extract, clove extract, chigaya extract, chinpi extract, touki extract, daffodil extract, tounin extract. , Spruce extract, Dokudami extract, Tomato extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakumondou extract, Parsley extract, Honey, Hamamelis extract, Parietaria extract, Hikiokoshi extract, Bisabolol, Loquat extract, Fukitampo extract , Fukinotou extract, butterbur extract, butcher bloom extract, grape extract, propolis, loofah extract, safflower Vinegar, peppermint extract, lime extract, button extract, hops extract, pine extract, horse chestnut extract, skunk cabbage extract, Sapindus extract, Melissa extract, peach, cornflower extract, eucalyptus extract, saxifrage extract, Yuzuekisu,
Yokuinin extract, mugwort extract, lavender extract,
Examples thereof include apple extract, lettuce extract, lemon extract, lotus root extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract and the like.

Deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, biopolymer such as hydrolyzed eggshell membrane, amino acid, sarcosine, N
-Amino acid derivatives such as methyl-L-serine, polyhydric alcohols, sugars, sodium lactate, urea, sodium pyrrolidonecarboxylate, betaine, moisturizers such as whey, oily sphingolipids, ceramides, cholesterol, cholesterol derivatives, phospholipids, etc. Ingredients, ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, anti-inflammatory agents such as hydrocortisone, vitamins A, B2, B6, C, D, E, calcium pantothenate, biotin, nicotinamide, Vitamin C esters and other vitamins, allantoin, diisopropylamine dichloroacetic acid, active ingredients such as 4-aminomethylcyclohexanecarboxylic acid, vitamin C, vitamin C derivatives, arbutin, kojic acid, ellagic acid, oil-soluble licorice extract, rhododine Whitening agents such as ndrodol, rhododendrol glycoside, raspberry ketone, raspberry ketone glycoside, antioxidants such as tocopherol, carotenoid, flavonoid, tannin, lignan, saponin, α-
Hydroxy acids and salts thereof, cell activating agents such as β-hydroxy acids and salts thereof, γ-oryzanol, blood circulation promoters such as vitamin E derivatives, retinol, wound healing agents such as retinol derivatives, hinokitiol, camphor, 1-menthol, γ-aminobutyric acid and the like can be mentioned.

The coloring component of the present invention refers to a colored material used for improving visual appeal and product image. Examples of the coloring component include red iron oxide, activated carbon, yellow iron oxide, black iron oxide, chromium oxide, carbon black, colored pigments such as ultramarine blue and navy blue, white pigments such as zinc oxide, titanium oxide, cerium oxide and barium sulfate, talc, Mica, sericite,
Kaolin, extender pigments such as barium sulfate in plate form, titanium mica, titanium mica treated with carmine, bismuth oxychloride, pigments such as pearl pigments such as fish scale foil, and food red, but are not limited to these. Any of the products commonly used in cosmetics can be used together.

The scrubbing agent comprising the silk fibroin of the present invention can be blended in various cosmetics. Specific examples thereof include face wash, shampoo, body shampoo, hand soap, dentifrice, pack agent, Body massage agents, body pack agents and the like can be mentioned. The dosage form is solid, cream paste, gel / liquid, granule /
There are a wide variety of powders, but there is no particular limitation. Generally contains surfactants, oils, preservatives, fragrances, salts, chelating agents, neutralizing agents, pH adjusting agents, chemicals, humectants, viscosity adjusting agents, polishing /
It consists of scrubbing agents. When used for these purposes, it can be used in combination with the above-mentioned cosmetic material.

The method of adding the scrubbing agent comprising the silk fibroin of the present invention to cosmetics is not particularly limited, but it is added to the aqueous phase or the oil phase in advance in the usual cosmetic production process, or water is added. It does not matter if the phase and the oil phase are mixed and then added. If the detergent formulation is in the form of granules or powder, it is added and mixed as it is.

The scrubbing agent comprising silk fibroin of the present invention can be blended in a skin abrasion device. The skin scraping tool according to the present invention is used for scraping off the hardened stratum corneum by rubbing the thick and hard portion of the stratum corneum, for example, the heel portion, and not only the heel portion but also the elbow and knee. A tool for rubbing the skin, which is formed of resin, sponge, or the like, can obtain a proper shaving action even when removing the hardened stratum corneum. The shape of the skin abrasion device is not particularly limited, but the scrub is adhered to one side of a cloth,
Examples thereof include those formed so as to cover a main body portion made of a porous elastic body such as a foamable synthetic resin material as disclosed in JP-A-2001-105331. The manufacturing method is not particularly limited. When adhering the scrub to the cloth, granular silk fibroin as disclosed in Japanese Patent Application No. 2001-105521 by the present applicant may be optionally mixed.

[0030]

The thus obtained scrubbing agent comprising the silk fibroin of the present invention has visual and tactile sensations that cannot be felt by conventional silk fibroin powder, and its presence can be directly confirmed. . Further, it can be used in the same manner as in the conventional scrubbing, while making the best use of silk's unique skin beautifulness effect, hydrophilicity, and affinity for skin. When blended in cosmetics, a cosmetic excellent in usability, visual appeal, and functionality can be obtained without impairing the original effect / efficacy of the cosmetic. For example, when blended with a cleaning or massage agent, scrubbing agents made of conventional plant materials and cellulose materials can be used while retaining the effect of removing waste and sebum and keratin by scrubbing, dust adhering to the skin surface, and massage effects. The silk-derived amino acid polymer and other physiologically active components directly act on damaged skin and the like, which could not be achieved by the scrubbing agent of 1. Even when used as a skin scraping tool, it can exert exfoliating function while retaining the silk's beautiful skin-protecting and skin-protecting effects similar to those using silk powder. It is a new scrubbing agent. In addition, the manufacturing method is industrially easy and inexpensive and excellent in economic efficiency.

[0031]

EXAMPLES An example of the present invention will be described below with reference to examples. The% notation in the examples represents mass%, and the hardness was measured by the following procedure. Gently take any one particle of the silk fibroin scrubbing agent, sandwich the scrubbing agent between a pair of upper and lower smooth glass plates with one fixed and the other vertically moving, and add a weight on the movable glass plate. Deformation due to cracking / crushing of the scrubbing agent is visually confirmed, and the weight value at the time when the scrubbing agent is deformed is read. The operation 10
The particles were continuously measured and the average value of the weighted values was defined as the hardness [g / particle] of the scrubbing agent.

[Example 1] Twisted yarn, which is a raw material for a silk fibroin colloidal solution, was mixed with 1.0% Marcel soap solution (bath ratio 3
The mixture was boiled and scoured for 1 hour to remove sericin, washed with water and dried with hot air. Then, the de-sericin twisted yarn waste was kneaded and dissolved in a heated 38.0% calcium chloride aqueous solution at a bath ratio of 5 using a kneader. After removing impurities by filtration,
Dialyze and desalt using a hollow fiber type dialysis device,
An aqueous silk fibroin solution was obtained. The silk fibroin colloidal solution thus obtained had a silk fibroin concentration of 5.5%.

Then, at room temperature, the aqueous solution was applied with a shear of 3000 rpm by an agitator having an angled fan turbine type four blades. At the beginning of stirring, foaming peculiar to the protein solution was observed and the apparent volume increased to about 3 times. When the stirring was continued, the volume gradually started to be reduced after about 1 hour. After about 2 hours, the whole was formed as a white, fine gel-like substance and lost its fluidity. The precipitation was promoted and completed over a further 30 minutes. Subsequently, the gel-like material was dehydrated by a centrifuge, passed through a 4000 μm mesh, and then dried with hot air using a tray dryer. The thus obtained silk fibroin scrubbing agent was a light brown granular material, and the yield thereof was 99% based on the silk fibroin content contained in the silk fibroin colloidal solution used. Finally, coarse particles were cut with a 500 μm mesh, and fine particles were cut with a 180 μm mesh to obtain a product. The yield by the sieving is 82
%was. Further, the hardness of the obtained product was 182.0 g / grain, which had an appropriate hardness, and thus was suitable for use as a scrubbing agent for cosmetics.

[Example 2] An aqueous dispersion containing 0.2% of red No. 226 as a coloring component based on the silk fibroin content was prepared, and the colorant was dispersed under stirring of the silk fibroin colloidal solution obtained in Example 1. The solution was added and the operation was carried out according to Example 1. The gel-like material obtained by dehydration with a centrifuge was passed through a 2000 μm mesh and freeze-dried with a freeze dryer. The silk fibroin thus obtained was a pale red, very bulky granular material, and its yield was 98% based on the silk fibroin content contained in the silk fibroin colloid solution used. This was sieved using a sieving machine in which "2000 µm mesh-1000 µm mesh-500 µm mesh-receiver" were superposed in this order. The coarse particles remaining on the 20000 μm mesh were separately crushed, and the whole amount was passed through the 2000 μm mesh. In that case, the acquisition ratio under each sieve was 40% -29% -31% in descending order. Of this, 1000 μm
The hardness of the scrubbing agent consisting of silk fibroin under the mesh and -500 mesh μm was 67.8 g / grain. Since it has a characteristic of being porous as compared with Example 1, it was suitable for a formulation requiring easy disintegration.

[Example 3] Tocopherol acetate was added as a physiologically active ingredient to the silk fibroin colloidal solution obtained in Example 1, and with stirring, blue No. 1 aluminum lake was added as a coloring component in an amount of 0.5% based on the silk fibroin content. Aqueous dispersion was added. Thereafter, the procedure is carried out according to Example 1, and after recrystallization, washing, dehydration, crushing and heat drying are carried out to obtain 300 to 500.
The μm particles could be sieved. The content of tocopherol acetate in the obtained blue silk fibroin scrub preparation containing tocopherol acetate was 6.1%.

Example 4 As the transparent soap scrub agent, the red silk fibroin scrub agent prepared in Example 2 was used. First, 1 to 7 of the compositions shown in Table 2 were charged in a reaction kettle and saponified. Then 8
And 9 were added to adjust the free alkali, and finally 10 to 12 were added. After cooling and solidification, the product was cut and dried and aged according to a standard method to obtain a product.

[0037] (Table 1) 1. Beef tallow 22.0 2. Coconut oil 10.0 3. Castor oil 4.0 4. Olive oil 4.0 5. Sodium hydroxide 6.0 6. Ethanol 20.0 7. Water 20.0 8. Sugar 8.9 9. Glycerin 3.9 10. Scrubbing agent of Example 2 0.2 11. Fragrance 0.9 12. Etidronate 4Na 0.1

In the obtained transparent soap, the light red scrubbing agent was visible in the system. The scrubbing agent that emerges from the inside of the soap gradually wears down as it is used, so that the soap can be suitably used as a soap in which the skin beautiful effect of the amino acid polymer can be expected.

[Example 5] As a powder dentifrice scrub agent, the tocopherol acetate-containing blue silk fibroin scrub agent prepared in Example 3 was used. First, among the compositions shown in Table 1, 1 to 3 were powder-mixed with a mixer, and then 4 was dissolved in an appropriate amount of purified water as a granulating agent and then 5 was added, and the powder mixture was granulated. , 300-500μ
A granulated product of m was obtained. Next, 6 was mixed with the granulated product to obtain a product.

[0040] (Table 2) 1. Carbonate Ca 94.0 2. Lauryl sulfate Na 1.9 3. Saccharinna Na 0.1 4. Hydroxypropyl cellulose 1.5 5. Fragrance suitable amount 6. Scrubbing agent of Example 3 2.5

The dentifrice thus obtained can be used in the same manner as an ordinary dentifrice, and the scrub agent exerts a physical action to remove plaque, and tocopherol acetate has a peripheral vasodilating action and a blood circulation promoting action. It was a good thing to expect.

[Example 6] As a face-wash gel soap scrub agent, an oil-soluble chamomile extract entrapped with silk fibroin was prepared. A silk fibroin colloidal solution prepared according to a conventional method was used in Example 3
The oil-soluble chamomile extract and the yellow No. 4 aluminum lake were mixed according to the above, and after recrystallization, washing, dehydration, crushing, and freeze drying were carried out. After that, only particles of 150 to 500 μm could be sieved. Yellow No. 4 aluminum lake was 0. 0 for the silk fibroin content in the silk fibroin colloidal solution.
The amount was 7%. The oil-soluble chamomile extract content of the obtained oil-soluble chamomile extract-containing yellow silk fibroin particles is
It was 8.3%.

First, among the compositions shown in Table 3, 1 was diluted with an appropriate amount of 13 and 2 to 5 were added. Then, 6 to 9 which had been mixed in advance were added and well stirred. 10 and 1
The pH was adjusted with 1 and 12 was added at the end to obtain a product.

[0044] (Table 3) 1. (Alkyl acrylate / Steares-20) Copolymer 1.2 2. Cocoyl Hydrolyzed Collagen K 2.9 3. Lauroyl Hydrolyzed Silk Na 3.4 4. Cocamide DEA 1.5 5.30% Lauryl betaine 6.0 6.25% Isostearoyl Hydrolyzed Collagen AMPD 2.0 7. Paraoxybenzoate 0.3 8. EDTA-2Na 0.05 9. Oil-soluble chamomile extract-containing yellow silk fibroin scrub agent 1.0 10. AMP suitable amount 11. Citric acid 12. Fragrance suitable amount 13. 100 water left Surplus

The obtained product was suitable as a gel soap containing a scrubbing agent, having a smooth feeling in use and also having a soft scrubbing function suitable for face washing.

Example 7 Slimming Gel As a scrubbing agent composed of silk fibroin particles, a lipase entrapped with silk fibroin was prepared. The preparation method was according to Japanese Patent Publication No. 60-13672. However, the drying was based on freeze-drying. The surface of the resulting silk fibroin particles was then coated with methicone to impart water repellency, and finally 50
Only particles of 0-2000 μm could be sieved. The lipase-containing silk fibroin particles obtained had a lipase titer of 2 units /
It was g. The titer of lipase was in accordance with the lipase titer test method of the general test method for compounding ingredients standard for each cosmetic variety. First, Table 4
2 of the compositions shown in 1 was sufficiently dispersed. Then premixed 3 to 5 was added and finally 6 to 10 also premixed to make the product.

[0047] (Table 4) 1. Water 3.0 2. Carbomer 0.3 3. Glycerin 100 and the rest Surplus 4. TEA 0.3 5. Fragrance suitable amount 6. Arnica extract 0.2 7. Time extract 0.2 8. Brown algae extract 0.3 9. Silk fibroin scrub containing lipase 2.0 10. BG 5.0

The slimming agent obtained was a suitable one having both a slimming function and a massage effect by scrubbing.

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Claims (4)

[Claims] 1. A silk fibroin having an average particle size of 150.
A scrubbing agent prepared in such a manner that the scrubbing agent is prepared in the range of ˜2000 μm. 2. A cosmetic comprising the scrubbing agent according to claim 1. 3. A skin abrasion tool comprising the scrubbing agent according to claim 1. 4. The method for producing a scrubbing agent according to claim 1, which is obtained by recrystallization from a silk fibroin colloidal solution.