JP2003113064A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a safe skin care preparation having skin bleaching effect, active oxygen suppressing effect, rough skin improving effect, effect for improving the stretch and crease of the skin and effect for improving the spreadability of cosmetics. SOLUTION: The skin care preparation having improved skin bleaching effect, active oxygen suppressing effect, rough skin improving effect, effect for improving the stretch and crease of the skin and effect for improving the stretchability of cosmetics is produced by formulating the extract of one or more kinds of plants of the genus Clerodendrum, family Verbenaceae, the genus Polypodium, family Polypodiaceae and the genus Asplenium, family Polypodiceae. These herbs have been long used as medicines and the complete safety of the herbs has been confirmed by various tests.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin such as medicines, quasi drugs and cosmetics. More specifically, the present invention relates to a safe and effective external preparation for skin, which comprises one or more kinds of extracts of plants belonging to the genus Cladophoraceae, Ezodenta genus, and Chasencida genus, which belongs to the family Ulaboshi.

[0002]

2. Description of the Related Art The genus Litaria is a plant belonging to the family of sub-flowers of the joint venture, Lepidoptera, and Vine family. Matsurika (scientific name = Cler
edrond fragrans), warbler heron (scientific name = Clerodendrome inme),
Toruso (Scientific name = Clerodendrom fo
rtuunatum), casobangil (scientific name = Cler
odendrom medium, Daisei (scientific name = Clerodend symtoph
ylum), Canton Higiri (scientific name = Cleroden
drom kwangtungense), Higiri (scientific name = Clerodendrom japonicu)
m), Singandan (scientific name = Clerodendrom)
bungei), rabbit (scientific name = Clerodend)
rom trichotomum), Ryusenka (scientific name = Clerodendrom paniculatu)
Plants such as m) are known.

The genus Ezodenta is a plant belonging to the genus Carnivora, Lepidoptera, and Coccinaceae. Noxinobu (scientific name = Pol
ypodium thumbergianus or L
episorus thunbergianus), Aone vine (Scientific name = Polypodium nipon)
icum or Marginaria niponic
a), Miyano Kino Knob (Scientific name = Polypodium
usuruense or Lepisorus u
sseriensis), Mitsudeurabosi (scientific name = Po
lypodium hastatum or Phyma
topsiahastata or Crypsinus
hastus), Tomoa Onezura (scientific name = Po
Lypodium amoenum), Black honeysuckle (Scientific name = Polypodium pseudo-am)
oenum), Ooezenda (scientific name = Polypod
Plants such as ium vulgare) are known.

The genus Chasencida is a plant belonging to the genus Carnivora, Lepidoptera, and Coccinaceae. Kobanohinokishida (scientific name = Asplenium sarelii), Toranooshida (scientific name = Asplenium incisum), Tokiwa fern (scientific name = Asplenium planica)
ule), Chassentida (scientific name = Aspleniumt
Richomanes), Shima Otaniwatari (scientific name =
Aspleniumidus), honey chasenida (scientific name = Asplenium tripteropu
Plants such as s) are known.

[0005]

The external preparations for skin such as cosmetics may be continuously used for a long period of time, and since they are applied to organs having a large area of the skin, safety is the most important item. In addition, although there are various effects required for external preparations for skin, whitening is one of the important effects of external preparations for skin, especially since white skin is preferred in Japan. Further, there is a demand for an effect of improving rough skin, an effect of improving skin stickiness, wrinkles, and an effect of improving cosmetic paste.

[0006]

Means for Solving the Invention As a result of intensive studies in consideration of safety and effectiveness on the skin, as a result of the investigation, the genus Magnolia,
It has been found that it is optimal for the purpose of the present invention to incorporate an extract of a plant belonging to the genus Ezodenta of the family Ophiaceae and a plant of the genus Chasencida of the family Ophiaceae.

[0007] Extracts of plants of the genus Cladophoraceae genus, the genus Ezodenta genus, and the genus Chasencida genus of the abalone family are not particularly limited in their use method, but when used as an extract, the extraction is facilitated. Therefore, if necessary, cut and pulverize with a mixer or the like. This is extracted with water or a hydrophilic organic solvent. The hydrophilic organic solvent used is extracted with methanol, ethanol, acetone, glycerin, 1,3 butylene glycol, propylene glycol, etc., or a mixture thereof, or a mixture of one or more hydrophilic organic solvents and water. However, since it is a preparation to be applied to the skin, a solvent such as water, ethanol, or glycerin that does not pose a problem even when used in an external preparation for skin has a wider range of applications because it is not necessary to distill off the solvent. In our experiments, hot water extraction or a low concentration aqueous hydrophilic organic solvent solution is preferred. The extraction conditions vary depending on the degree of cutting, the purpose of cutting, and the type of solvent, but when water alone is used, heating can be performed considerably, and even if the temperature is raised to 100 ° C., the decrease in effectiveness does not decrease significantly. Depending on the type of solvent and the formulation of the external preparation for skin, part or all of the solvent is distilled off. This is blended in a skin external preparation.

[0008] An extract of a plant of the genus Lynx of the Verniaceae, the genus Ezodenta of the family Ulaboshi, or the plant of the genus Chasencida of the family Ulaboshi is compounded in the external preparation for skin. As 0.000
1 to 5.0% is preferable. Further, since other ingredients to be blended are not limited, they may be freely selected, but it is natural to choose a material which does not violate the spirit of the external preparation for skin of the present invention which is safe and effective. Is. Therefore, whitening, antioxidant, cell activation (prevention of cell aging), moisturizing,
Combined use with various agents effective in preventing and improving skin roughness makes the object of the present invention more effective. In addition, there is no problem in selecting an arbitrary dosage form such as cream, emulsion, lotion, pack, spray and gel depending on the application.

The following is a description of manufacturing examples and examples in which the manufacturing examples are mixed, which are examples of actual extraction methods, but the invention is not limited thereto.

Production Example-1 100 g of dried pinewood leaf was shredded, and then purified water 2
After adding kg, the mixture was heated to 80 ° C., allowed to cool 5 hours later, filtered with filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-2 After drying 100 g of dried leaves of privet heron, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred for 10 times.
After standing for one day, the solution was filtered through filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-3 After cutting 100 g of the dried product of the roots of the scrotum, shredded water, 1 kg of purified water and 1 kg of 1,3 butylene glycol were added,
The mixture was allowed to stand for 10 days with stirring, filtered through a filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-4 100 g of the dried product of corn root was shredded, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred for 10
After standing for one day, the solution was filtered through filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-5 After cutting 100 g of the dried product of the leaves of corn millet into small pieces, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred for 10 times.
After standing for one day, the solution was filtered through filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-6 100 g of dried casobangil leaves were shredded, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred for 10 times.
After standing for one day, the solution was filtered through filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-7 100 g of dried barley of Daisei bark was shredded, 2 kg of purified water was added, the mixture was heated to 80 ° C., allowed to cool for 5 hours, filtered with filter paper, and the filtrate was depressurized. Concentrated.

Production Example-8 After 100 g of dried Daisei leaf was shredded, purified water 1
kg and 1 kg of ethanol were added, and the mixture was allowed to stand for 10 days with stirring, filtered with filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-9 After drying 100 g of dried canton higiri leaves, 1 kg of purified water and 1 kg of ethanol were added and stirred to 1
After standing for 0 days, the solution was filtered through a filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-10 After cutting 100 g of a dried product of Higiri leaf into pieces, 1 k of purified water
g and 1 kg of ethanol were added, and the mixture was allowed to stand with stirring for 10 days, filtered through filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-11 100 g of dried leaves of Shingandan leaf was shredded, 2 kg of purified water was added, the mixture was heated to 80 ° C., allowed to cool for 5 hours, filtered with filter paper, and the filtrate was depressurized. Concentrated.

Production Example-12 100 g of the dried product of all the strains of hare were chopped and purified water 2
After adding kg, the mixture was heated to 80 ° C., allowed to cool 5 hours later, filtered with filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-13 After drying 100 g of dried root of roots of roots, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred for 10 times.
After standing for one day, the solution was filtered through filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-14 100 g of dried Noxinob whole grass was shredded, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred for 10 hours.
After standing for one day, the solution was filtered through filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-15 100 g of the dried product of the whole grass of Acalyd Vinegar was shredded, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred to 1
After standing for 0 days, the solution was filtered through a filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-16 100 g of dried whole grass of Miyanoxinobu noso was shredded, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was left for 10 days while stirring. After filtering with filter paper, the filtrate was concentrated under reduced pressure. did.

Production Example-17 After cutting 100 g of a dried product of whole plant of Mitsudeurabosi,
Purified water (1 kg) and ethanol (1 kg) were added, and the mixture was allowed to stand with stirring for 10 days, filtered through a filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-18 After drying 100 g of a dried product of the whole plant of Spodoptera litura, 1 kg of purified water and 1 kg of ethanol were added, the mixture was allowed to stand for 10 days with stirring, filtered with a filter paper, and the filtrate was concentrated under reduced pressure. .

Production Example-19 After cutting 100 g of a dried product of whole plant of Ooezodenda,
Purified water (1 kg) and ethanol (1 kg) were added, and the mixture was allowed to stand with stirring for 10 days, filtered through a filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-20 100 g of a dried product of whole plant of Coba nohynoxyda was shredded, 2 kg of purified water was added, the mixture was heated to 80 ° C., allowed to cool for 5 hours, filtered with a filter paper, and the filtrate was obtained. It was concentrated under reduced pressure.

Production Example-21 100 g of a dried product of the whole plant of Toranooshida was shredded, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred to 1
After standing for 0 days, the solution was filtered through a filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-22 100 g of dried whole grass of Tokiwa fern was shredded, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred for 10
After standing for one day, the solution was filtered through filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-23 After cutting 100 g of dried whole grass of Chassium fern, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred to 1
After standing for 0 days, the solution was filtered through a filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-24 100 g of dried whole grass of Ootaniwatari was chopped, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was allowed to stand for 10 days with stirring. After filtering with filter paper, the filtrate was depressurized. Concentrated.

Production Example-25 100 g of dried honeysuckle fern whole grass was shredded, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was allowed to stand for 10 days while stirring. After filtering with filter paper, the filtrate was concentrated under reduced pressure. did.

In the examples, the formulations shown in Table 1 were used, and both A and B were dissolved by heating at 80 ° C., and B was gradually added to A while stirring and emulsified. A cream was prepared by a method of cooling while stirring, stopping stirring at 35 ° C., and allowing to stand.

[0036]

[Table 1]

Example 5 The example 1 of the example 1 was replaced by the example 4 of the production, and the other steps were the same as those of the example 1.

Example 6 The example 2 of the example 2 was replaced by the example 5 of the production, and the other steps were the same as those of the example 2.

Example 7 Production Example 3 of Example 3 was replaced with Production Example 6, and the others were produced in the same manner as in Example 3.

Example 8 Production Example 1 of Example 1 is Production Example 4 and Production Example 2 is Production Example 5
In the same manner as in Example 4, except that Manufacturing Example 3 was replaced with Manufacturing Example 6.

Example 9 The same procedure as in Example 1 was carried out except that Production Example 1 of Example 1 was replaced with Production Example 7.

Example 10 The example 2 of the example 2 was replaced with the example 8 of the production, and the other steps were the same as those of the example 2.

Example 11 The example 3 of the example 3 was replaced by the example 9 of the production, and the other steps were the same as those of the example 3.

Example 12 Production Example 1 of Example 1 is Production Example 7, Production Example 2 is Production Example 8
In the same manner as in Example 4, except that Manufacturing Example 3 was replaced with Manufacturing Example 9.

Example 13 The example 1 of the example 1 was replaced by the example 10 of the manufacturing method, and the other steps were the same as those of the example 1.

Example 14 The example 2 of the example 2 was replaced by the example 11 of the production, and the other steps were the same as those of the example 2.

Example 15 The example 3 of the example 3 was replaced by the example 12 of the production, and the other steps were the same as those of the example 3.

Example 16 Example 16 was prepared in the same manner as in Example 4 except that Manufacturing Example 1 was replaced with Manufacturing Example 10, Manufacturing Example 2 was replaced with Manufacturing Example 11, and Manufacturing Example 3 was replaced with Manufacturing Example 12.

Example 17 The example 1 of the example 1 was replaced with the example 13 of the production, and the other steps were the same as those of the example 1.

Example 18 The example 2 of the example 2 was replaced with the example 14 of the production, and the other steps were the same as those of the example 2.

Example 19 The example 3 of the example 3 was replaced by the example 15 of the production, and the other steps were the same as those of the example 3.

Example 20 The production example 1 of the example 1 was replaced with the production example 12, the production example 2 was replaced with the production example 13, the production example 3 was replaced with the production example 6, and the other example 1
It was created in the same manner as 4.

Example 21 The example 1 of the example 1 was replaced with the example 16 of the manufacturing method, and the other steps were the same as those of the example 1.

Example 22 The example 2 of the example 2 was replaced by the example 17 of the production, and the other steps were the same as those of the example 2.

Example 23 The same procedure as in Example 3 was carried out except that Production Example 3 of Example 3 was replaced with Production Example 18.

Example 24 Production Example 1 of Example 1 was replaced with Production Example 16, Production Example 2 was replaced with Production Example 17, Production Example 3 was replaced with Production Example 18, and the other steps were produced in the same manner as in Example 4.

Example 25 The example 1 of the example 1 was replaced with the example 19 of the production, and the other steps were the same as those of the example 1.

Example 26 The example 2 of the example 2 was replaced with the example 20 of the production, and the other steps were the same as those of the example 2.

Example 27 The example 3 of the example 3 was replaced by the example 21 of the production, and the other steps were the same as those of the example 3.

Example 28 Example 6 was produced in the same manner as in Example 4 except that Production Example 1 of Example 1 was replaced with Production Example 19, Production Example 2 was replaced with Production Example 20, and Production Example 3 was replaced with Production Example 21.

Example 29 Production Example 1 of Example 1 was replaced with Production Example 22 and the other production was performed in the same manner as in Example 1.

Example 30 The example 2 of the example 2 was replaced by the example 23 of the production, and the other steps were the same as those of the example 2.

Example 31 Production Example 3 of Example 3 was replaced with Production Example 24, and the other production was performed in the same manner as in Example 3.

Example 32 Example 1 was prepared in the same manner as Example 4 except that Production Example 1 was replaced with Production Example 22, Production Example 2 was replaced with Production Example 23, and Production Example 3 was replaced with Production Example 24.

Example 33 The example 1 of the example 1 was replaced with the example 25 of the production, and the other steps were the same as those of the example 1.

The following experiment was conducted to confirm the effect.

5 people per experiment, 6
After months of use, we asked about the whiteness of skin, the effect of improving skin roughness, the effect of improving skin stickiness, wrinkles, and the amount of makeup applied. The results are shown in Tables 2 and 3. Numbers represent average values. (Note that
No one complained of skin abnormalities during the test period) Greatly improved compared to before use 3 Improved compared to before use 2 Slightly improved compared to before use 1 Change from before use None 0 Worse than before use -1 Worse than before use -2 Very worse than before use -3

[0068]

[Table 2]

[0069]

[Table 3]

Regarding the safety test, a primary skin irritation test, a cumulative skin irritation test, a sensitization test and a human patch test were carried out, but there were no problems.

[0071]

EFFECTS OF THE INVENTION A skin external preparation characterized by containing one or more kinds of extracts of the plants of the genus Magpie of the family Cladophoraceae, the genus Ezodenta of the family Ulaboshi, and the plants of the genus Chasencida of the family Uraboshi are whitening effects, skin roughening improving effects, It was found that it is highly effective as an external preparation for the skin because it improves the skin's stickiness, the effect of improving wrinkles and the paste of makeup. It has also been edible since ancient times,
Needless to say, there is no problem in safety from the results of various tests.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61P 17/16 A61P 17/16

Claims (3)

[Claims] 1. An external preparation for skin, which comprises one or more kinds of extracts of plants of the genus Magnolia of the family Nematode, the genus Ezodenta of the family Laboscide and the plant of Chasencida of the family Laboscide. 2. The external preparation for skin according to claim 1, wherein the plants of the genus Magpie are Matsukari, Ignataria, Strawberry, Casobangil, Daisei, Canton Higiri, Higiri, Shingandan, Heron, Ryusenka. 3. The plant belonging to the genus Ezodenta of the genus Ulaboshi is Noki nob, Aonekazura, Miyamanoxinobu, Mitsudeurabosi, Tomoonekazura, Ooezodenda.
3. A skin external preparation according to claim 1, wherein the plants of the genus Chasencida are Cobanohinida, Toranooshida, Tokiwashida, Chasenshida, Shimaotaniwatari, Honeychasenida.