JP2003183118A - Gel composition and emulsified composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a gel composition and an emulsified composition which have high oil emulsifying performance, excellent stability with time, low irritation to skin, and high safety. <P>SOLUTION: The compositions contain a compound represented by formula 1 (R<SP>1</SP>is amino acid, R<SP>2</SP>is an alkyl and R<SP>3</SP>is hydrogen) and/or its salt. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a gel composition and an emulsified composition containing the compound represented by the general formula 1 and / or a salt thereof.
More specifically, by containing the compound represented by the general formula 1 and / or a salt thereof, a gel composition having high emulsifying ability of oil, excellent stability over time, and low irritation to skin and high safety And an emulsified composition.

[0002]

2. Description of the Related Art In recent years, studies have been made on the use of natural or derived surface-active substances as emulsifiers in terms of human safety. In such a situation, Bacillus sub
The surface-active substance represented by the general formula 1 secreted and produced in the process of fermentation by a microorganism represented by tilis and the like is also expected as a highly safe natural emulsifier, and various emulsification methods have been studied.

Further, regarding cosmetic compositions for external application to humans, gel compositions and emulsion compositions using surface-active substances which are excellent in stability over time, have low irritation to the skin, and are highly safe. I have been asked.

[0004]

[Problems to be Solved by the Invention] In such a situation,
The function required for an external preparation for skin such as cosmetics is a system utilizing a surfactant derived from a natural product, that is, a so-called biosurfactant, to obtain a gel composition and an emulsion composition, and further, the gel composition. That is, by adding water to the emulsion, it is possible to efficiently form fine emulsion particles that are stable over time with a physically weak stirring force, and to have low irritation to the skin.

[0005]

Means for Solving the Problems The inventors of the present invention have made extensive studies in view of such circumstances, and as a result, by containing the compound represented by the general formula 1 and / or a salt thereof, the self-organizing ability is high, Excellent stability over time, high oil emulsifying ability, low irritation to the skin and high safety,
The invention of a gel composition and an emulsion composition was completed.

That is, the gel composition and the emulsified composition of the present invention contain the compound represented by the general formula 1 and / or a salt thereof and have high self-organizing ability.
The composition is excellent in stability over time, has a high oil emulsifying ability, has low irritation to the skin, and is highly safe.

The structure of the present invention will be described in detail below.

The substance of the general formula 1 used in the present invention is Ba
It is a so-called biosurfactant, which is secreted and produced in the process of fermentation by a microorganism represented by Cillus subtilis.

Specifically, R ¹ is an amino acid, and most of them are selected from L-leucine, L-isoleucine and L-valine. R ² is alkyl having a carbon chain of C _{8 to} C ₂₂ , which may be linear, branched, cyclic, and saturated or unsaturated. As R ³ , hydrogen or a salt can be used, and an alkali metal salt such as sodium salt or potassium salt is used. Further, a mixed system thereof may be used.

In the compound represented by the general formula 1 used in the present invention, R ¹ is L-leucine, R ² is the general formula 2, and R ³ is sodium. Further, the content is not particularly limited, but is preferably 0.1 to 10% by weight, and if it is less than 0.1% by weight, the gel composition and the emulsion composition are inferior in gel forming ability and emulsifying ability and are stable. May not be obtained, and it is possible to contain more than 10% by weight, but it is not economical as a gel composition and an emulsion composition.

In addition to the above-mentioned essential components, the composition of the present invention may contain various components such as cosmetics, quasi drugs, pharmaceuticals and the like which are commonly used in external preparations for skin, and components which are used in foods. For example, oily ingredients, lipids, humectants, thickeners, medicinal ingredients, bactericidal / preservatives, pigments, powders, pH adjusters, UV absorbers, antioxidants, plasticizers, fragrances, amino acids, sweeteners, colorants. Etc. can be blended appropriately. Further, other surfactants can be blended in the role of assisting gel forming ability and emulsifying ability.

Specific examples of the oily component include liquid paraffin, petrolatum, microcrystalline wax, squalane, jojoba oil, beeswax, carnauba wax, lanolin, olive oil, coconut oil, and higher alcohols.
Examples thereof include fatty acids, esters of higher alcohols and fatty acids, silicone oils and the like. Examples of moisturizers include glycerin, sorbitol, xylitol, maltitol, propylene glycol, polyethylene glycol, 1,3-
Butylene glycol and the like can be mentioned. Examples of the thickener include carboxyvinyl polymers, xanthan gum, methylcellulose, polyvinylpyrrolidone, gelatin, clay minerals such as bentonite, and the like. Examples of the medicinal component include various vitamins and their derivatives, allantoin, glycyrrhizic acid and its derivatives, various animal and plant extracts, and the like. Furthermore, as an emulsifier,
For example, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, nonionic surfactant such as polyoxyethylene hydrogenated castor oil, sodium stearoyl lactylate And the like, amphoteric surfactants such as soybean phospholipids, and cationic surfactants such as alkyltrimethylammonium chloride.

The gel composition and the emulsified composition of the present invention can be produced by a known method and can be used regardless of the fields of cosmetics, quasi drugs, external medicines, foods, etc. The mold can be arbitrarily selected according to the purpose, and can be in the form of cream, emulsion, lotion, gel, ointment, pack, stick or the like.

[0014]

INDUSTRIAL APPLICABILITY The gel composition and emulsion composition of the present invention contain the compound represented by the general formula 1 and / or a salt thereof, and are naturally used or conventionally derived surface active agents. Compared to the substance, the emulsifying ability of oil is high, the stability over time is excellent, the irritation to the skin is low, and the safety is excellent.

In order to demonstrate these effects, Examples 1 to 1
9 and Comparative Examples 1-8 were prepared and evaluated.

Prior to the examples, the gelation method, emulsification method, evaluation of stability over time, and evaluation method of skin irritation used in the present invention will be described.

(Gelification method) After the surface-active substance and glycerin (part A) were sufficiently stirred at room temperature according to the following formulation,
The oil phase (part B) which was heated to 60 ° C. and also heated to 60 ° C. was gradually added to part A with stirring. Then, it cooled to room temperature and obtained the gel composition.

[0018]     A surface-active substance 3.0% by weight         Glycerin 4.0     B Squalane 50.0         Liquid paraffin 43.0

(Emulsification method) After the surface-active substance and glycerin (part A) were sufficiently stirred at room temperature according to the following formulation, 6
The oil phase (part B) heated to 0 ° C and also to 60 ° C is
Slowly add to the above with stirring. Then, the aqueous phase (part C) heated to 70 ° C. was added, and the mixture was cooled to room temperature with stirring to obtain an emulsified composition.

[0020]     A surface-active substance 3.0% by weight         Glycerin 4.0     B Squalane 20.0         Liquid paraffin 20.0     C 1,3-butylene glycol 10.0         Preservative Suitable amount         Purified water residue

(Evaluation of temporal stability of gel composition) 50 ° C.
The state after storage for 2 weeks was visually observed, and the temporal stability was evaluated according to the following criteria. ◎: No change compared to immediately after gelation ○: White turbidity or remarkable change in viscosity compared to immediately after gelation △: Oil bleeding out ×: Gel collapsed and clear separation is observed

(Evaluation of stability of emulsion composition over time) 50 ° C.
After 2 weeks of storage, the state was visually observed and observed with an optical microscope, and the temporal stability was evaluated according to the following criteria. ⊚: Both appearance and emulsified particles are the same as immediately after emulsification, and the emulsified particles are 2 μm or less. ◯: No change in appearance is observed, but some emulsified particles are 2 μm or more. Δ: No separation is observed, but the emulsified particles are large and non-uniform. ×: Separation is observed

(Evaluation of skin irritation) Haye's
Using Test Chamber (manufactured by Yayoi Co., Ltd.), the sample was affixed to the skin of the inner part of the left forearm of 20 test subjects for 24 hours. The determination was made 1 and 24 hours after the sample was removed according to the following criteria. Degree of skin reaction No evaluation 0 Light erythema 0.5 Erythema 1.0 Erythema + papules or edema 2.0 Erythema + papules, edema + blisters 3.0 Blisters 4.0 After each subject was evaluated, its evaluation The average of the points was used as the average evaluation point, and the skin irritation was evaluated according to the following criteria. ◎: Less than 0.15 ○: 0.15 or more and less than 0.30 △: 0.30 or more and less than 0.60 ×: 0.60 or more

[0024]

[Table 1]

As shown in Table 1, as the surface-active substance, R ^{1 of the} compound represented by the general formula ¹ is L-leucine, R ² is the general formula 2, and R ³ is sodium (hereinafter referred to as sample 1). The gel composition of Example 1 and the emulsified composition of Example 2 had good results with respect to stability over time and skin irritation, as compared with the natural or surface-active substances derived from Comparative Examples.

[0026]

[Table 2]

As shown in Examples 3 to 6 of Table 2, particularly in the range of 0.1 to 10% by weight of sample 1, stability with time and irritation to skin were good.

As described above, according to the present invention, by containing the compound represented by the general formula 1 and / or the salt thereof, the emulsifying ability of oil is high and the stability with time is excellent. It is possible to provide a gel composition and an emulsified composition having low irritation to the skin and high safety.

[0029]

EXAMPLES The present invention will now be described with reference to examples, but the present invention is not limited thereto.

[0030]   Example 7 Moisturizing gel cream     A sample 1 2.0% by weight         Glycerin 5.0     B Squalane 40.0         Octyldodecyl myristate 50.0         Stearyl alcohol 2.0         Cetanol 1.0         Vitamin E acetate moderate amount         Fragrance suitable amount

After heating the parts A and B to 60 ° C.,
Parts are gradually added to part A with stirring to obtain a gel composition. Then cool to room temperature. The obtained gel composition was excellent in stability over time, had low irritation to the skin, and was a good moisturizing gel cream.

[0032] Example 8 Cleansing Gel A sample 2 5.0 wt% ^{(R 1} of Formula 1 is L- valine, ^{R 2} is alkyl of saturated branched _C 14 _{~ 16,} ^{R 3} is hydrogen) Sucrose fatty acid ester 1.0 Glycerin 5.0 B Liquid paraffin 50.0 Isononyl isononanoate 20.0 Nylon powder 1.0 Fragrance suitable amount C 1,3-butylene glycol 5.0 Carboxyvinyl polymer 1.0 Sodium hydroxide 0.5 Xanthan gum 0 .2 Preservative A suitable amount Purified water Residual

After heating the parts A and B to 60 ° C.,
Parts are gradually added to part A with stirring to obtain a gel composition. After that, part C heated to 70 ° C. is added and the mixture is emulsified with stirring and cooled to room temperature. The resulting cleansing composition is a good emulsion composition having a particle size of 2 μm or less, and has stability over time,
The irritation to the skin was good. Also, the feeling of use was refreshing and there was no stickiness.

Example 9 Suspension type lotion A Sample 3 1.0% by weight (R ^{1 of} general formula ¹ is L-leucine, R ² is a C ₁₈ branched alkyl, R ³ is potassium) Glycerin 1.0 B Sunflower oil 5.0 Jojoba oil 5.0 Vitamin A palmitate 0.1 Perfume proper amount C preservative proper amount pH adjuster proper amount purified water residual

After heating the parts A and B to 60 ° C.,
Parts are gradually added to part A with stirring to obtain a gel composition. After that, part C heated to 70 ° C. is added and the mixture is emulsified with stirring and cooled to room temperature. The resulting suspension-type lotion was a good emulsion composition having a particle size of 2 μm or less, and had good stability over time and good skin irritation. Also, the feeling of use was refreshing and there was no stickiness.

─────────────────────────────────────────────────── ─── Continued Front Page (51) Int.Cl. ⁷ Identification Code FI Theme Coat (Reference) A61K 7/48 A61K 7/48 9/06 9/06 9/107 9/107 47/42 47/42 B01F 17/28 B01F 17/28 17/44 17/44 // C07K 7/00 C07K 7/00 (72) Inventor Jiro Kitahara 2-7 Torimi-cho, Nishi-ku, Aichi Prefecture Japan Menard Cosmetics Research Institute (72) Satoru Nakata Satoru Nakata 2-7 Torimicho, Nishi-ku, Nagoya, Aichi Japan General Cosmetics Co., Ltd. Research Institute F-term (reference) 4C076 AA09 AA17 BB31 CC18 DD01 DD34 DD38 EE41 FF36 FF56 4C083 AA122 AB032 AC022 AC072 AC122 AC352 AD072 AD092 AD222 AD352 AD411 AD412 AD622 AD662 BB01 BB41 BB44 CC04 CC05 CC23 DD23 DD27 DD31 DD41 EE01 EE06 EE10 EE12 FF01 4D077 AA09 AB08 AB11 AB12 AC02 CA11 DC02X DC06X DC10X DC28X DC42X 4H045 AA10 AA30 BA BA34 CA11 EA15 EA35 FA73

Claims (6)

[Claims] 1. A gel composition comprising a compound represented by the general formula 1 (R ¹ is an amino acid, R ² is alkyl, R ³ is hydrogen) and / or a salt thereof. [Chemical 1] 2. R ^{1 in the} general formula 1 is an amino acid selected from L-leucine, L-isoleucine and L-valine, and R 1
The gel composition according to claim 1, wherein ² is C _{8 to} C ₂₂ alkyl, and R ³ is hydrogen or an alkali metal. 3. The gel composition according to claim 1, wherein R ^{1 in the} general formula 1 is L-leucine, R ² is the general formula 2, and R ³ is sodium. [Chemical 2] 4. The gel composition according to claim 1, wherein the compound of the general formula 1 and / or its salt is contained in an amount of 0.1 to 10% by weight. 5. An emulsified composition obtained by adding water to the gel composition according to claim 1 to emulsify it. 6. The gel composition and / or the emulsified composition according to claim 1, which is used as a skin external preparation.