JP2003183171A - Elastase activity inhibitor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a novel and safe elastase activity inhibitor or a cosmetic composition. <P>SOLUTION: The elastase activity inhibitor as well as the cosmetic composition contain one or more extracts from plants selected from Potentilla tormentilla, Juniperus rigita and Astragalus sinicus, having elastase activity inhibitory effect, effective for anti-aging skin care by restoring elasticity and clear complexion, and by repairing slacks and wrinkles, which can be used as various types of formulations such as pharmaceuticals, quasi-drugs, cosmetics as well as other general food and beverage products. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to application to an elastase activity inhibitor or a cosmetic composition containing one or more kinds of plant extracts selected from tormentilla, mouse, and lotus root.

[0002]

2. Description of the Related Art A typical change in human skin aging is wrinkles and tarmi, which is one of the major skin problems for older people and women. However, at present, effective treatments for skin wrinkles and tarmi are hardly found, and various studies on aging have come to be conducted in the aging society.

[0003] At present, it is considered that the formation of wrinkles and tarmi on human skin is caused by a decrease in elasticity of the skin. However, as a specific histological phenomenon,
Changes in extracellular matrix components such as elastin, collagen, and glycosaminoglycans in the dermis can be mentioned, and it is known that changes in elastin are particularly important.

That is, it is considered that the decrease in skin elasticity occurring during the formation of wrinkles and tarmi is related to the degeneration of the three-dimensional structure due to the damage of elastin, which is produced and secreted by elastase produced by dermal fibroblasts. It is important to prevent the formation of wrinkles and tarmi, that is, to prevent skin aging, by suppressing the activity of elastase and preventing the degeneration of elastin that maintains the elasticity and tension of the skin.

[0005]

Therefore, the present invention suppresses the activity of elastase and restores and maintains the elasticity and elasticity of the skin to prevent the aging of the skin and prevent youthful skin from wrinkles and tarmi. It is an object of the present invention to provide an inhibitor of elastase activity (anti-aging agent) having an effect of maintaining

[0006]

In view of such circumstances, the present inventors have made the development of a useful plant having an elastase activity-inhibiting action, and as a result, tolmentilla, a mouse,
It was confirmed that one or more kinds of plant extracts selected from astragalus significantly suppressed the activity of elastase. And give the skin gloss and tension. Further, the present invention is completed by providing a highly safe elastase activity inhibitor or a cosmetic composition capable of maintaining the skin free of wrinkles and tarmi because it prevents the denaturation of elastin which is an elastic fiber. Came to.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The term "tormentila" used in the present invention means Rosaceae and Genus Potenti.
Lla L.) plants: Potentilla tormentilla "P.tor
mentilla Schrank (= P.Silvestris Necker) "flower, spike, pericarp, fruit, cone, stem, leaf, branch, branch, stem, bark,
Rhizome, root bark, roots, tuberous roots, seeds or whole plants are used, but in addition, the same plant, P. chinensis Ser., P. chinensis Fr.et Sav., Tsutiguri (P.discol)
or Bunge), persimmon white (P. fragarioides L.), honey bee goose (P. freyniana Bornm.), king robin (P. fruti)
cosa L.), Hakurobai (P.davurica (Nestl.)), Miyakinbai (P.matsumurae Th.Wolf), Chishimakinbai (P.meg)
alantha Takeda), P. sprengeliana Leh
m.), the snake strawberry "P. sundaica (Bl.) OK" and the like can also be used.

The term "mouse" (also known as "Morimatsu"") used in the present invention means Cupressaceae, genus Jus.
niperus) plant: Nezu (Juniperus rigida Sieb.et Zuc
c.), Pacific nezu (J. communis L.), Heinez (J.confe
rta Parl.) flower, spike, pericarp, fruit, cone, stem, leaf,
Branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants are used, but in addition, Miyanezu "J. communis" of the same genus plant is used.
L. var.nipponica (Max.) Wils. ", Rishirijakshin (J.co
mmunis L.var saxatilis Pall.) etc. can also be used.

In addition, the term "Astragalus (also known as lotus root, astragalus, safflower)" used in the present invention means a leguminous family (Legumino).
sae), Astragalus plant: Astragalus (Astra
galus sinicus L.) flower, spike, pericarp, fruit, cone,
Stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants are used, but other plants belonging to the same family (A. adscendens
Boiss.et Haussk.ex Boiss), Purple Momuzu (A.ad
surgens Pall.), (A.boeticus L.), (A.caryocarpus Ke
r-Gawl.), (A.cicer L.), (A.falcatus Lam.), (A.glyc
yphyllus L.), (A.hamomus L.), Astragalus `` A.mem
branaceus (Fisch.) Bunge ", momenzuru (A. reflexistipu
lus Miq.) etc. can also be used.

The extract of Tormentilla, Nezu and Astragalus used in the present invention means various parts of each plant (flower,
(Spears, pericarps, fruits, cones, stems, leaves, branches, branches and leaves, stems, barks, rhizomes, root bark, roots, tuberous roots, seeds or whole plants) as they are or after crushing and squeezing. Alternatively, it is extracted with a solvent as it is or after pulverization.

The extraction solvent for the above-mentioned various plant extracts may be selected in consideration of the purpose of use, the type of product to be provided, the processing to be performed later, etc.
Water, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, etc. or hydrous lower alcohols, propylene glycol, 1,3-butylene glycol, polyhydric alcohols such as glycerin, or hydrous polyhydric alcohols, acetone, acetic acid It is desirable to use one or a mixture of two or more selected from various organic solvents such as ethyl. However,
When the content of the organic solvent is not preferable depending on the purpose of use, water alone may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixture with water. You can use the extracted one.
Furthermore, it can be used in a state where each solvent extract is combined.

[0012] In addition to the hydrolytic extraction of the above-mentioned various plants by enzymatic decomposition, those hydrolyzed by acid / alkali can also be used.

The production method is not particularly limited, but it is usually within the range of the boiling point of the solvent at room temperature and atmospheric pressure, and after extraction, filtration or ion exchange resin is used for adsorption / adsorption.
It may be decolorized and purified to form a solution, paste, gel or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added within a range that does not affect the effect, and as a purification treatment means such as deodorization and decolorization. It suffices to use an activated carbon column or the like, and any ordinary means generally applied depending on the extraction substance may be arbitrarily selected. It is also possible to add an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, or an arbitrary mixed liquid thereof to the extracted liquid after extraction. The obtained extract can be used as it is, but can also be used as a paste or powder by concentrating and drying.

The various plant extracts of Tormentilla, Nezu and Forsythia of the present invention can be contained in an elastase activity inhibitor and a cosmetic composition, and the content thereof is not particularly specified, and the elastase activity inhibitor and the cosmetic composition are not specified. Slightly different depending on type of composition, quality, and expected degree of action, usually 0.0001% by mass in terms of solid content in the total amount of the preparation.
Above (hereinafter, expressed in%), preferably 0.01 to 50.0%. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so as to have the same concentration.

Further, the dosage form / form of the elastase activity inhibitor and the cosmetic composition of the present invention is arbitrary, including capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, creams,
It can be mixed and used in the form of an ointment, a sheet or the like.

The fields of application thereof are, for example, all kinds of external preparations (including preparations used for animals) in general, and specifically, ampoules, capsules, pills, tablets, powders, granules, solids, Liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (e.g. Basic cosmetics such as water, emulsions, creams, ointments, lotions, oils, packs, facial cleansers, skin cleansers, massage agents, cleansing agents, depilatory agents, depilatory agents, shaving treatment agents, aftershave lotions, pre-shows Lotion, shaving cream,
Makeup cosmetics such as foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail enamel, nail enamel, nail enamel remover, poultice,
Plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal or / and cosmetic preparations (for example, shampoo, rinse, hair treatment, pre-hair treatment) applied to the scalp and hair. Agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair styling agents, hair growth and hair nourishing agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 5) For baths to be used Agents, 6) In addition, axillary deodorants, deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpaste, mouthwash, mouthwash, etc.

In addition to the above-mentioned essential components, the elastase activity inhibitor and cosmetic composition of the present invention may optionally contain the components and additives exemplified below, as long as the effects of the present invention are not impaired. The content in the preparation is not particularly specified, but usually 0.0001 to
50% is preferred.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange lafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, Persic oil, Castor oil, Cottonseed oil, Peanut oil, Turtle oil, Mink oil, Egg yolk oil, Palm oil, Palm kernel oil, Owl, Palm oil, Beef tallow, Lard, Squalene,
Squalane, pristane or hydrogenated products of these oils (hardened oil, etc.), etc.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcrystalline wax, etc.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(5) alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(6) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) with alkylene (C2-C4) oxide such as ethylene oxide added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylates, polyalkylene oxides such as polyethylene oxide and polypropylene oxide Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (ether type nonionic Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) , Protein hydrolyzate derivatives,
Polymer surfactant, surfactant containing titanium / silicon,
Fluorocarbon type surfactant) etc.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), other, essential fatty acid (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Alternatively, amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant- or animal-based raw materials These are processed (eg, crushed, milled, washed, hydrolyzed, etc.) in a conventional manner depending on the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are selected and combined), and various materials are selected. You can select it and use it.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol, isopropyl is used. Alcohol, lower alcohol such as butanol, isobutanol or hydrous lower alcohol, polyhydric alcohol such as propylene glycol, 1,3-butylene glycol, glycerin or hydrous polyhydric alcohol, various organic solvents such as acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more of them. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixed solution with water, or Exploited extract may be used.

Additives derived from plant or animal raw materials are
When used as a systemic or topical external preparation, cosmetics, including protection of skin and hair, moisturizing, improvement of touch and texture,
Giving flexibility, reducing irritation, relieving stress caused by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing rough skin and improving it, hair growth, hair growth, hair loss prevention, gloss , Cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
The effects of antiseptic and buffer can be expected.

As a concrete plant (crude drug) used as a raw material,
For example, almonds, ai, blue vines
(Seifufuji), Aoki (Aoki), Aogiri or Kenashiaogiri
(Goji paulownia), Aotsutsurafuji (Kibo), Aotenma, Acacia, Red capsicum (Akasoma), Redcurrant `` fruit '', Red clover, Red grapes, Red amber (Logwood), Red algae (Red bud), Red pine or Red madder or Red madder (Akane) (Grassroots), Akagia jiou or jiou (ground yellow),
Agi (A Wei), Aki Larch, Akinire (Resin), Aguay Gua Su, Aguahe (Omi Tenguyashi), Akebei
(Ki-dori), Asa (Asakojin), Malva Morning Glory or Morning Glory
(Dagushi), Hydrangea (hydrangea), Ashitaba (tomorrow leaf), Azuki (red azuki bean), Asunaro, Acerola, Asenyak (Asenyaku), Athira (Sakuyoukanna), anise, abiu, abiulana, canola, abemaki "fruit" ,Avocado,
Ama, Amacha (sweet tea), Amachatsuru, Amadokoro (Tamatake), Amana (Kokoji), Amaranthus (Hiyu, Hagatetow, Himegateto, Senninkoku, Sugimorigateto,
Hosoaogatetou, Aogatetou, Haribiyu, Aozulan, Amaranthus hippocondriacus), Amigasa lily or Fritillaria (shellfish), Aristromelia (Yurizuisen), Arcana (Arcanna), Algarrobo (Cabbage), Artea, Arnica, Alpinia or Katsumadai
(Souzuku), aloe (蘆 薆), aloe vera, angelica, apricot or hon apricot (apricot kernel), ansokkou (benzoin), yellow sapote, igakoukousrina (geijutsu), sardine or chinensis (indian cabbage), rush
(Wicked grass), Japanese knotweed (Kojo root), yew (first place), strawberry,
Fig (flowerless "fruits and leaves"), figs (first), hibiscus (winter aoi), Ichiyakuso (one medicinal herb), ginkgo (ginkgo biloba "seed, leaves"), Itohimehagi (distant), locust bean, Inunazuna (Taylexi) , Inubiyu (Honagainubiyu), rice "seed, seed coat", inondo "seed", Echinochloa japonica, nettle, ylang-ylang, iwatobacco (Iwabaki),
Iwahiba or Iwamatsu (wind roll), common bean, oolong tea, fennel (incense), wheat (Chibana), ukiyagara (Sanryo), Uguisukagura "fruit", Himeyokiou, turmeric (Yukin), duckweed (Ukiwa), Usubasaishin Or Keirin saishin or Sengoku saishin (spicy), mussels mallow, mung bean mallow, medusa orchid, nemophilus (summer hay), udo or shishido (invigoration, independence, indonesia), unyadegat (unkalia, cat's claw),
Uba Tea, Ume (Ume "seed, fruit pulp"), Vladimir Ogashira, Argentine (Rawberry), Unshu Mikan (Chenhide), Umboku, Estragon, Ezo-kogi (Ezo Goka), Ezo Suzuran, Echinashi (Hosobamurasakibareniku, Echinashi), Enishi Mushrooms), Ebisugusa or Cassia tora (Keiko), El Campre, Elderberry "fruit",
Elemi, Eryngii or Pre-Lotus erynge, Enju (Sophorae, Sophorae rice), Pea, Ougi or Kibanana
(Yellow radish), Naruco lily or Kagi Kurumabanaruko Yuri (Yellow), Ohihisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Houken, Ookarasuri (Calocon),
Plantain (Civil engineering incense), Giant tsuboji (Self-defense), Plantain
(Carmaco, Carophyllum), Milk thistle (Yuzhou Leopard, Bald Ear), Toucan Hazel (Haruko), Toucan Cactus, Obana Ochera or Ochera (White Sprout), Obana Sarsberg (Banaba), Ooba Yashaboshi "Fruit", "Fruit" Grains), Oomiacatetsu, Omihawthorn or Hawthorn
(Yamashiko), Omiyashi, Barley (barley), Oka, Okazeri (Heiwako), Okra "fruit", Oguruma (overturning), Oklurihigotai (Banzhou Leopard, Indigo Spin), Panax ginseng or Panax ginseng (carrot) , Hypericum perforatum or Hypericum perforatum or Hypericum perforatum (younger brother cut grass), Odorikosou (intermittent), Onami (blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninogagara
(Tianma), Oniyuri or Sasayuri or Hakatayuri (yuri),
Onoelan, Ononis, halibut, Ominaeshi
(Soy sauce), Oyuco, Dutch mustard (cresson), Dutch jelly, Dutch millet, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, peel",
Kaikaizou (ripe ground yellow), cacao "fruit, peel, seed", oyster (persimmon "leaf"), oyster vine (fishing hook), oyster or citrus root (rensenzo), oyster, hydrangea, cassia, casino ki ( (Fruit `` fruit ''), banyan tree (pepper), oak (camellia tree, camellia leaf), cascarilla, cascara sagrada, gypsophila, kasenso, cypress (Kinshato), kaniwa, carnation, valerian root, hippo,
Birch or weeping birch (white birch), gerbera, pumpkin, kapok cypress `` seed '', kahokusansho (shusho),
Cattail, chamomile or Roman chamomile, chamomile
(Grazing), cam cam (duck), karagwa or yamawawa
(Mulberry), color, calyx salmon, crow cucumber or cinnamon cucumber (royal melon), crow bishaku (half-summer), oats, guarana `` seed '', callahoo (bamboo), karaya, garyu, karin (wood melon), garcinia, kawamidori, kawajisha , Kawaratake, Kawaradeshiko (Ishitake) or Ezokawaranadeshiko (Barley, Tsubameko), Kawara carrot (Blue flesh), Kawamura mugwort (Inchinko), Kansui (Sweet), Licorice
(Licorice), cantara, candelilla, canto, canna, canlan, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, nawairo strawberry, maple strawberry,
European raspberries), kiwi "fruits, leaves", cichlids (melon roots), kyokyo (bellflowers, bellflowers), chrysanthemums (chrysanthemums,
Cicada daisies, Astragalus vulgaris, Amaranthaceae, Catalpa (Azusa), Rumex (Yotei), Kizitsu (Apricot), Kizuta, Kidachiaroe, Kidachiha, Kina, Kinaoki (Shinkona, Akakinanoki), Quinua (quinoa), Kakiha (yellow oak). Kimame, Gymnema sylvestre, Kimenkak, cabbage, cabbage "immature fruit", caraway, cucumber, goryu (Nishikawayanagi, Teyanagi), Kiraja saponaria, Kiraya, Kiranso (Kenshi Kobayashi), Kumquat "fruit", Kinkiju, Ginsekai, Kimbusen, betel,
Kinmizuhiki (Sensakurusu), Kinran, Ginran, Kinryohen, Guapaba Vermelha, Guava "Fruits", Guayule, Quercus Infectria (Gall), Kukui Nuts, Kugenumaran, Cuco (Glitters, Lances of the Barrels) Black-headed whale (Tenmon winter), kudzu
(Kakkon), camphor tree, gooseberry `` fruit '', carrot (yellow flower), kutiti river, gardenia (yamashiko), kunugi (brassica sol), cupua, cubebaba, kumazasa, tsuchidura (horse whiskers), clara (bittersweet) ), Cranberry “fruit”, chestnut “seed, fruit, astringent skin”, curculigo latifolia “fruit”, grapefruit “fruit / leaves”, buckthorn, black ganemochi (necessity of rescue), turtle beetle or black beetle or hikikoshiki (prolonged life grass), clove.
(Cloves, cloves), Gumbai nazuna (Sekimei, Sekimeishi), Keigai (Mature beetle, Magewort), Keitou (crown flower, corolla), geckavidin, bay (ken laurel), kenashi sartoriibara (earthen 苓苓, mountain return genus), gentiana, genchiana. (Old bird), Kemponashi (Kyugushi), Koukisekekoku, Citrus unshiu (Koji, Tachibana, Ovenimikan, Fukuromikan, Sagamikouji, Ponkan, Santara)
(Tachibana skin)), Kousimbara (Monthly flower), Kousui mint, Kozo `` fruit '', Kocha (black tea), Kouhone (river bone), Kouhon (Straw book, Karamoto book), Kouryan, Kori Ryokyo
(Kara Ginger), cilantro “fruit”, Kouren (Kuroren),
Scutellaria (yellow gon), cowberry (over Tachibana), coconut `` fruit '', goshuyu (gojutsu), gosho strawberry (covered bonito), pepper (pepper), cosmos, copaiba balsam, coffee `` seed, leaf '', kobushi or magnolia ( Spicy), burdock (burdock root, burdock root), Kobotsuduru, sesame seeds (sesame), sesame nohagusa (genus), Gomishi (seaweed witch) or vine vine or pine wilt or wheat (wheat), rice or rice bran `` red bran, white bran '', Rice oil, cola acluminata "seed", cola
Bella "seed", colony lya, fenugreek "fruit", Colombo, Conzurango, kelp, konjac, comfrey
(Final herb), sisal (sisal asa), saihairan, sakaneran (ezosakaneran), saxima button vine or cinna button vine or sinensenso (weapon), cherry tree
(Oshima cherry, Yamazakura, Oyama cherry, Ed Higashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "leaf, flower, fruit, bark (cherry bark)", cherry, pomegranate, sasan, sasanbagin , Sageomodaka (Sawaki), sweet potato, sugar cane, sugar beet, sanpeitojutsu (sour citrus fruit), saffron (bancoflower, west safflower), sapodilla, sapotea mario, pomelo "fruit", sabonsou, salmonberry "fruit", salinach
(Rima), Saranshito (sand indigo stab), Salvia (sage),
Pleurotus cornucopiae (mountain bell pepper), gurney (mountain walnut), Sankaku cactus, Sangre degrad (croton), Sankuyouso, Sanshichin ginseng (37 ginseng), Sanshuyu (Yamatake mushroom), Sansho (Japanese pepper), Sandscon (yamazu) Root), shea
(Karite), Cyanoki “fruit”, Shiitake mushroom (Shiitake), Zion
(Shion), winged bean, digitalis, shikunshi (Kimiko),
Perilla or Aojiso or Chimenjizo or Catamejizo
(Shiso leaf, Shiso), rosewood, linden, honoki,
Chinese Forsythia (Forsythia), Shimeji (Hinjimeji, Shakashimeji, Hatake Shimeji, Oshiroijimeji, Beech Shimeji, Honjimeshi, Shiratamogitake), Shimokuren (Spicion), Shimotsukisou, Potato, Peony (peony), Shajin
(Sasam), Jasmine (Matsurika), Janohige (Mugimon winter), Jurassic cowpea, Gypsophila paniculata, Shukshamitsu (Sanden, Crushed sand), Juzdama, Shiro "fruit", Shunran, Scotch palm, Ginger (ginger) ,
Zhouzan Hydrangea (Tsuneyama), Shobu (iris, iris root),
Shozuku "fruit", white oak "seed", silane (butterfly), white swan "seed", white clover (clover), white azuki bean (chicken bone grass), white banyan iris (smell iris), white clover "flower", white lupine, lupine,
Shirominanten (Nami Tenmi), Cinchona Succibula, Jinchoge (Mizuka, Mizukaka, Shichobana), Cinnamon, Cinnamomum cassia (cinnamon skin), Watermelon (watermelon), Honeysuckle
(Gold and silver flower, Shinobi winter), sorrel (acidic), swim berry “fruit”, star apple, stevia, strawberry “fruit”, Suzuko (Sir Xu), horsetail (question), purslane.
(Horse toothpaste, horse toothpaste), plum "fruit", surgaran
(Oran), Pinus sylvestris "cone", Larch arbutus, Ileus vulgaris, Walnut, Hawthorn vulgaris, Vaccinium vulgaris, Dandelion, Horse chestnut (Marronnier), Pear "fruit", Plum vulgaris, Elderflower (Elder), Achillea millefolium (Milfoil), Rose balsam, Steller's stinkweed, Horseshoe mistletoe, Sturgeon minnow or Strawweed minnow, Horseradish, Bunting stone (Stone root), Ginkgo (Prunus angustifolium, Gypsophila oleracea, Ginkgo serrata, Ovisnakusekoku, Shikokusaku, Honseakusaku, Honseokusekoku Deerbuckle, Kibana-no-Sekoku) (Dendrobium, Ishibana), Cedron (Bowshuboku), mallow, Hiroha Senega, Senega, Seri, Celery, Senkyu (River Kyu), Senshi Ren (穿心 communication), shear,
Sennin Cactus, Senna "Fruits, Leaves", Senninsou
(Daiba), senburi (medicated), senboku, souka (grass), elephant chow, sourdoughweed, buckwheat "seed seed", someiimo, broad bean, rhubarb (daikon), radish, soybean, red sea bream (orange skin, drought), scorpionfish Rurihigotai (Southeast Ai Stab),
Takasaburo (Dr. lotus), Takatodai (Ohjyushi), Takawarabi (Gourd), Dark sweet cherry "fruit", hollyhock, pearl oyster (thyme, Hyorika), Tachidokoro
(Haikai), Tachiyanagi, Tamarind "seed", onion, tamshiba (spicy), Taranoki "fruit, leaf, root bark", Tarayou (Obayu winter blue, single-leaf tea, chincho tea, dacha tea), dahlia
(Tenjiku Button), Tarwi, Tankirimame, Tanchiuchiwa, Tanjin (Ginseng), Dandelion (Ganko Hide) or Shirobana Dandelion or Moco Dandelion, Danmal, Cherry "fruit", Chigaya "fruit, root, sprout", Chixetsu ginseng (Bamboo ginseng) , Chicory, chanka piedra (traditional citrus), tulip, choconostay, artichoke (artichoke), ginseng (large yellow), ginseng (garden), ginseng (spiny leaves), choreimaitake (boiled boar), chologi. , Tsukisou, Tsukushimakaneran, Tsukuritake (mushroom), Tsuchiakebi, camellia, Centella asiatica, Clover (lacquer grass), Tsuyukusa (duckweed grass), Tsuzuki Azuki (red adzuki bean), Tsurutsuchia vine, Tsukudami (Japanese sardine), Apricot (Apricot), Tsuruna, Tsuna (Yoshiba ginseng),
Glycine soja, Tsuwabuki, Deiko, Walnut, Duberry "Fruit", Amaranthus, Tencha (green tea), Tendaiyaku (crow), Pepper (winter gourd), Pine vine, Capsicum (Pancho), Pepper (attributable), Pimples (spotted) Marigold), Gleditsia sinensis, Touna Bena (river cutting), corn or corn hair (nanban hair), squirrel mochi (sadako), gentian or gentian (dragon gall), horsetail (tree bandit), dokudami (ten drug), turmeric (conger) Roots), Toshishi or bean bug or Nennifolia oleracea, Eucommia vulgaris (Musaka "bark, leaves, roots"), Ash (harp peel), tomato, tragacanth, triacanthus "seed", lisianthus, dolonoki, troloaoi, dragonfly, nigerian berry "fruit" ], Chinese yam or yam (mountain drug), Nagikadada (Butcher bloom), Naginatakouju, Na Cucumber, rapeseed, peanut or horizontal sticker (sword bean), nut mandarin, jujube
(Oju), Naniwaibara (Kinsakurako), Navena (interrupted), Nameko, Peanut (peanut), Nanten (Namitenmi), Nanbankaramushi (Cara hemp), Nioisumire, Nigaki (Garden tree), Nigamogi (Garden) , Japanese nutmeg, Kei or Nikkei or Ceylon Nikkei or Yab Nikkei (cinnamon) or Keishi (Keushi),
Black-throated Plover, Chinese chive (Nishiko), Elderberry (Oscullet tree `` fruit, flower, stem, leaf ''), garlic (large garlic), Nurude (quintet), leek, nectar or nebu or nevi or nemoki or digobana (hymn), thistle (Oyagi), Neubara (Fruit), Nostoc communis (Ryohaku), Nogetou, Yarrow, Nodake (Former Hu), Novara, Peach, Pineapple `` fruit '', Hibiscus (Bushouge, Furinbusouge, Roselle), Hyelindo, Houssewa, Peach, , Hakamaurabosi (bone fracture), Hakukayutomu, Chinese cabbage, Chinese cabbage (tinea bark), Huckleberry "fruits", chickweed (harsh), hazel (harbor), hasilidokoro
(Roth root), basil, lotus (lotus, lotus meat, lotus root), parsley
(Netherlands jelly), hadakamugi, batata, bee weed, or bamboo shoots (boiled bamboo), patchouli, mint (light load, light load leaf), hassho beans, pearl barley (Yokuinin), hanasuge (knowledge mother), banana, hanahakka, hanabishi (shitsuri, shitsuri) , Vanilla vins, papayas, yellow squirrels (mouse koji), pahalobobo, hub "whole grass, stems, leaves", paprika, stilts,
Hamago or Mitsuba Hamago (vine vine), Hamasuge (Kafuzi), Hamabishi (Shitsuriko), Hamanasu (maikai flower), Hamaboufu (hama windbreak), Hamamelis, palm, rose (rose), balata, balata, aratake mushroom,
White-bellied agaric, Usukimorinokasa), Haran, Pariurus (Rhododendron japonicum), Parietaria, Harkanran, Balsamina (Tsurureishi, Nigauri), Harunire
(Insect skin, Elm skin, Insect leaf), Barbasco, Harlindo, Handaikai (Katsu Omi), Panoki, Hyogi (Hikari), Pea nuts, Carrots
(Gypsum, Liu Singh), Higulmadaria, Higotai, Hishi
(Hishimi), pistachio, beet, tsutsumi (Ishidashi), hibiscus edulis, daisies (daisies), Hinako no Kozuchi
(Cow knee), Hydrangea cypress, cypress, hiba, castor, sunflower, bell pepper, Himeuzu (Aoi), himemagama (garlic), Himematsutake (Kawariharatake, Hiromatsutake), Himemuyoran, Pimenta "fruits", juniper, Japanese juniper, Japanese juniper "Fruit", chickpeas, lentils, biloba mallow,
Broad-brushed balsam (bald oak), loquat "fruits, leaves, stems", areca (daisy skin, calyx), puerh tea, futokazura
(South rattan), butterbur, butterbur dandelion (submarine winter flower, subterranean winter leaf), wisteria kama (Orchid grass), wisteria beans (flat bean), wisteria wisteria (chocolate, seeds, leaves), grape "fruit, fruit skin, seeds, leaves", beech, fuyu mucinsk Bamboo shoots (caterpillar), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, Black currant "fruit", Blackberry,
Branjeen, Plum "fruits", Fluceraria, Blueberries (Hemaceae), Prune, Floral Blanca, Blonde Psyllium, Bungou (mung bean), Hazelnuts, Loofah, Hetukaran, Safflowers (Hanaken), Henneken, Belladonna, Berries "fruits", Persear , Peruvian Berg, Pereschia grandifolia, red quince or duckweed (Keiten), Boysenberry "fruit",
Broomwood or elderweed or Nendou or Hahakigi Kochia (ground silkworm), Hosairan, Housengka (Fengxen, acute child, skeleton grass), Pouteria sapota, Pouteria lucuma, honoki, spinach, physalis (Toro root), honoki (Japanese sum) Hoboku, magnolia, bokeh (wood melon), moss leaf brackish (bittersweet), mosquito grass, cornflower (soup), mosquito peony (Kagetensanchi), moss barrengi, bodaiju (Bodhi tree), button (peony `` flower, leaf '' , Stem, bark "), button pi (peony skin), hops, jojoba, bourgei (Ruricha), Bordeaux, white berry" fruit ", Hongonik (Meat Juyo, Daiei), Hongsekoku (Tetsuseki Miso, Suzuyama Ishihasu) ), Maizuru Tennan Show (Tiannan Star), Maitake (Maitake), Maou (Maho), Maca, Macadamia nuts, Margaret (Mokshungik), Macri (Marine grass), Ma Wa (mulberry bark "bark, leaves"), magnolia sprengueri, Masalanduba, Masalanzuva de Ceara, Masheira de Boi, Mashua (Tamanouzenhallen, kyukonkinrenka), Matatabi (wooden sword), Matsukasa, Pine "leaves, bark, roots", Matta Orho, Matsuhodo (boiled peony), Matico (Cordon sillo), Mayoram (Hanahakka), Malvanojadine (bitter), Mulberry "fruit",
Quince, malein (billot mullein), mango,
Mangosteen, Manzania (Andean chamomile), Manchuria walnut, Mandarin "fruit", Ganoderma lucidum (Ganoderma lucidum), Pheasant (Fructus "Fruit"), Mishima Psycho (Saiko), Water plantain or Water morning glory (Rhinoglossum), Half-legged beetle Lotus), Misohagi (Cendula napus), Michiyanagi or Niwayanagi
(Collecting), Mitsugashiwa, Mitsuba, Midori Zapote, Midori mint, mimosa, mioga, Miracle fruit "fruit",
Myrrh, Myrobalan, Strawweed, Stinkweed (Kaki), Mukunoki, Mukoji (Prolonged skin), Munya, Purple (purple),
Murasakikib or Oomurasakikib (purple), Murasaki corn, Murasaki Natsuji (Kunmei chicken blood wisteria), Megakansa opuntica, Mehajiki (bamboo grass), Mebugi,
Evening primrose (Evening primrose), Melaleuca, Melissa, Meliroth, Melon "fruit", Muco mugwort, Mousou chiku, Mokkirin, Moje (pepper japonica), Mochinoki, Mokko (wooden incense), maple bud, Peach (peaches "leaves, seeds, flowers," Fruits)), bean sprouts, morelo cherry “fruits”,
Morohaya (burlap), Yawakawamurasaki yak, Yakuchi (Yoshichi), cornflower (cornflower), cornflower,
Yacon, Yashabushi (arrow wheel) or Himeyashabushi or Obayayashabushi "fruit, fruit skin, fruit ear", willow willow, octagonal disc, mistletoe (willow parasitism), willow (Kawayanagi, Tachiyanagi, weeping willow, pussy willow, willow dog, willow dog, willow dog, willow dog, willow dog Koyanagi, Unryu-willow, Miyanagi-yanagi, palm, yamayanagi, willow, weeping willow, fox willow, doronoki), willow tree "leaf, stem", narcissus, yam koji
(Purple gold beef), yab tobacco (Tsuru, Tenmeisei), pokeweed (Shokuriku), yamahanoki (Yamaharu), bayberry (Yangmei skin), yamamogimo, eucalyptus, Yukinoshita (tiger ear grass), yucca or flavifolia, yuzu `` "Fruits", lilies, yellow sedges, mugwort (leaf buds), ligans (thunder maru), lime "fruits", rye, lakanka "fruits", raspberries "leaves, fruits", latania (clameria), lacquer or shallots (flasks), lavender. , Longan (dragon meat), agave (Aono agave, fukurin agave),
Ryokucha (green tea), apple "fruit, seed, leaf, root", gentian, rubus or Suavesimus (hushun), thistle (this is Vladivore Higotai, Xinjiang indigo head), litchi (lunch, leek branch), lettuce (chisha) , Red currant "fruit",
Red pitaya, lemon "fruit", lemongrass, forsythia or Chinese forsythia (ream), waxy (wax plum), wax palm, locon (reed, root), loganberry "fruit",
Rosemary (mannen wax), rose hips (novara),
Examples include wasabi, cottonweed (Japanese sage flower), and fireweed (earthen).

Examples of seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Sudiaonori, Hiraaoonori, Bouaoonori, Hosoedaonori), Ananaosa (sea algae), Kind: kelp (Macombus, liquorice, Hosomekonbu, Mitsuishikonbu), wakame, hirome, aowakame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitrus ruetokeana), hijiki, hibamata, sea uchiwa, usubaumiu Kirebano Miuchiwa, Akabawa Miuchiwa, Kona Miuchiwa, Okinouchiwa, Usuyukiuchiwa, Etsuukiumiuchiwa], Seaweed [Red algae: Hijirimen, Hexamela, Hirakusa, Onik , Obakusa, Kataobakusa,
Yatabegusa, Yukigiri, Amanita, Tosakanori, Togekirinsai, Amaxakirinsai, Giraffe, Jakushinkirinsai, Tsunomata, Obatatsunomata, Tochaka (Nyakuzuna-no-Tomashita), Ezotsunomatsuta, Togenomata, Hirasakonotoma, Kotobuki, Kotobuki, Kotobushi
[Yaleus Banori, Kagious Banori, Suzius Banori, Haius Banori, Akamomijinori] and the like.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Anemone: Quanonimo, Volvox: Ohigewawari, Volbox, Palmera, Yotsumeu, Genus Aomizu: Hizaori, Ao midori, Genus Tsurugimido, Genus Himidoro: Hibimidoro, Genus Aosa: Anaaosa, Amiosa, Nagaaosa, Kawanori: Kawanori,
Fruicula genus, Shiogusa genus: Oenothera genus, Asamidoriushigusa, Kawashiogusa, Marimo, Baronia genus: Tamagobalonia, Tamabaronia, Magatagum genus: Magata, Iwachia genus: Fusaiwaduta, Black squirrel, Mildewer, Black millet, Nematoda, Hagemonia, Nematoda. Sakibutimir, Nagamir, Hiramiru, and Kasanori:
Casanori, genus genus: Futozuzumo, Tamazuzumo,
(Mizujuzumo, Mikadzuki genus, Colecaete genus, Tsudumimo genus, Kikkokusa genus: Kikkokusa, Astragalus genus: Hitogusa, Hirohanohitohegusa, Usutoegusa, Motukihitoe, Sayamidoro, etc.

Blue-green algae (genus Suizenjinori: genus Suizenjinori, genus Water-bloom, genus Nostoc: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aiacacio), etc.).

Brown algae (Pyraera: Pyraera, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Prickly squirrel, Ulaboshihaha, Symphalida: Symphologus, Cyperus genus: Cyperus cypress, Konaumi uchiwa, Akabayumi uchiwa, Namikura genus: Prunus chinensis, Somexaceae genus: Somenaceae
Pinus genus: Matsumo, Nagamatsu genus: Nagamatsu moth, Okinawa mozuku genus: Okinawa mozuku, Niceft mozuku genus: Physcomit genus, Physmozuku genus: Physcomitum genus: Genus mosquito: Genus mosquito: Genus moss, Genus moss Isige, Iroro, Ichimegasa: Ichimegasa, Calligraphy: Calli, Umibosu: Umibosu, Urushigusa: Urushigusa,
Black cypress, Tobacco bug, Genus: Haemorium, Haberdoki: Haberodoki, Havanori: Havanori, Habernori: Hazelnut, Common genus: Common butterbur, Ezoburo genus: Nematode: Nephila, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Pleurotus vulgaris Genus Kagomenori: genus Kagomenori, genus Muralis: murachidori, genus Phalaenopsis: shark
Sardine: Sardine, Asclepias: Asclepias, Kayamonori: Kayamonori, Fennel genus: Fennel, Tsurumo: Tsurumo, Anata: Squirrel, Susume: Aedes albopictus, Missus konjac, Miscanthus, Aedes radisculent, konjac beetle, konjac beetle, scutella conserved , Onikonbu, Goheikonbu, Nagakombu, Pea kombi, Otojijimokubu, Tororokonbu genus: Tororocombu, Antocume: Antokume, Kajime: Kajime, Tsuruarame, Kurume, Chrysanthemum genus: Chrysanthemum genus: Necrochamus genus, Black konjac genus, Black locust, Black civet, : Catfish,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

Red algae (genus: Kensuke Nori, Funori Nousuke, genus Anoly: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Pteridophytes: Pleurotus, Pleurotus: Pleurotus: Rumex, Ryumonsou: Ryumonsou, Hera Ryumon, Nymphalaceae: Nisekarekigusa: Okitsubara genus: Psyllium syllabus: Acacia
Naminohana, Coral Spodoptera: Rattlefish, Shiogusagoromo: Shiogusagoromo, Ivanoka genus: Etsukiiwanokawa, Kainokawa: Kainokawa, Kanitonote: Kaninote, Corydalis, Dendrobium, Scutellaria, Dioscorea, Rhizophorus, Scutellaria, Saccharomyces , Tambanori, slippery,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Amanita genus: Nectaria vulgaris, Fushiklenori genus: Fushiklenori, Namibia genus: Pleurotus cornucopiae, Cyprinidae: Pleurotus genus, Periwinkle genus: Periwinkle, Prunus genus: Pleurotus genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhizopus, Fujimatsumo: Fujimatsumo, Sawtooth genus: Toothbrush Mushrooms, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Algae (genus Chara, genus Citra,
The genus Rhizopus: Rhizophyllum, the genus Lichnotamnus, the genus Flamus: Himaflamus, Chaboflamus, Tripera, etc.), the yellow algae (Genus Hikarimo: Hikarimo, etc.), etc.

Materials derived from animal-derived materials include poultry extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or its decomposed product, beef or pig. Brain tissue extract, hydrolyzed collagen hydrolyzate (acid, alkali, enzyme, etc.) of cattle, pigs or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin of cattle or pigs or elastin hydrolyzate (acid , Alkali, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or bovine blood cell protein degradation product (globin peptide), to cow or pig Degraded products of hemoglobin (hemin, hematin, heme, protoheme, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

As a material derived from a plant or animal material, any site derived from a gene recombinant or a cell fusion,
Cells, tissues, organs, metabolites, etc. can also be used.
Furthermore, for example, an undifferentiated cell group, a cell group in the process of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can be used.

(14) Marine components Seawater such as deep water, for example, seawater salt, seawater dried product, inorganic salt (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic Ocean or the Pacific Ocean, sea mud Or mud (fango), for example, sea mud or mud of various places such as Italian fango, German fango, Eifelfango, and Freiburgfango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitoku stone, kurogite etc.

(15) Microorganism culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, fungus or actinomycete metabolite, fungus or actinomycete extract, natto metabolite, natto extract, Fermented rice extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermented product of raw milk or skim milk powder, fermented product of lactic acid bacterium of legumes, lactic acid bacterium of coconut plant Fermented material, etc.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, Gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) Ultraviolet absorbing / blocking agent Benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), para-aminobenzoic acid derivative ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline Derivative, pyrimidine derivative,
Dioxane derivative, camphor derivative, furan derivative,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escarol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening agent Para-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative,
Nucleic acid derivative, allantoin derivative, nicotinic acid derivative,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract. , Ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivative (hydroquinone benzyl ether, etc.), kojic acid or its derivative, vitamin E or Derivatives thereof, N-acetyltyrosine or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou,
Clara, mugwort, honeysuckle, yellowfin, duckweed, matsuhod, pearl barley, syringa, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankeishi, hamarisu, karaguawa or yamgua, enryakushi, bellflower, toshishi, zaiko, ejaculate Mahuang, senkyu,
Dokatsu, Psycho, Bow-fu, Hama-bo-fu, Oogon, Peony skin, Peonies, Geno-shoko, Kakkon, Licorice, Quintuple, Aloe, Shouma, Safflower, Green tea, Black tea, Asakuyaku) etc.

(21) Melanin dye reducing / decomposing substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether)
etc.

(22) Turnover promoting action / cell activating substance Hydroquinone, lactic acid bacterium extract, placenta extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, dragonfly, horsetail, gentian, burdock,
Sikon, carrot, hamamelis, hop, yokinin,
Odori Koso, Assemblies, Touki, Daffodil, Amacha, Hypericum, Cucumber, Prickly Pear,
Mannenrou, parsley) etc.

(23) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

(25) Antioxidant Vitamin C or its salt, stearic acid ester, vitamin E or its derivative, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamorin, Gossypol, Propolis etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame cultured cells, armature,
Hypericum, Hamamelis, Clove, Melissa, Crassulaceae, Birch, Salvia, Mannenrow, Nantenmi, Ages, Ginkgo, green tea) etc.

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, chamazulen, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, shikon extract, agets extract, propolis and the like.

(28) Antibacterial / bactericidal / disinfectant acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercury chrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, porridge powder, iodine compound,
Iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarbane, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant Agents (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (odor Trimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jermal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, kujin, propolis, etc. .

(29) Humectant Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprylcaprate, glycolic acid (α-hydroxy acid),
Hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidonecarboxylic acid or its salt, sodium lactate, urea, sorbitol, amino acid or its derivative (valine, leucine, isoleucine, threonine, methionine). , Phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine,
Cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine, their sulfates, phosphates, nitrates, citrates or pyrrolidonecarboxylic acid), oils and fats " Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange lafer oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, quince seed oil, kukui nut oil, safflower oil, shea Fat, liquid shea fat, soybean oil, camellia oil, corn oil,
Rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mokurou, palm oil, eucalyptus oil, beef tallow, pork Fats, squalene, squalane, pristane or hydrogenated products of these oils (hardened oil) ", waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax,
Rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax), Bacillus natto metabolite, natto extract,
Silk fiber extract, plant extract (red pine sap, aloe, kudzu root,
Chamomile, licorice, cucumber, licorice, rice or rice bran, purple root,
White birch or white birch sap, assembly, mulberry bark, biwa leaf, loofah, peony bark, peony) etc.

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (salmon, Hypericum, Clara, mulberry leaf, cinnamon, ginger ginger, comfrey, salvia, elderberry, bodige, button pipi), seaweed extract and the like.

(31) Hair agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantol, castari tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(32) Antiandrogens Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(33) Peripheral vascular blood flow enhancer Vitamin E or its derivative, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Capsicum tincture, nonyl acid vanilamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

(36) Antiseborrheic agent pyridoxine or its derivative, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

(38) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxytripolyphosphate, sodium bromate, potassium bromate, pyroline peroxide Sodium acid salt, sodium peroxide orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract, etc.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(40) Hair swelling agent Ethanolamine, urea, guanidine, etc.

(41) Dyeing agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-Nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

42) Fragrances Natural animal fragrances such as musk, civet, catrium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, karaway essential oil, cardamom essential oil, guaiac wood. Essential oil, cumin essential oil, black character essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western mint Essential oil, large scented essential oil, tuberose essential oil, Choji essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, Hiba essential oil,
Sandalwood Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Vetiver Essential Oil, Bergamot Essential Oil, Peruvian Balsam Essential Oil, Boad Rose Essential Oil, Homou Essential Oil, Mandarin Essential Oil, Eucalyptus Essential Oil, Lime Essential Oil, Lavender Essential Oil, Linaloe Essential Oil, Lemongrass Essential Oil, Lemon Essential Oil, Rosemary Essential Oil (Mannen wax) Essential oils, vegetable flavors such as Japanese peppermint essential oil, and other synthetic flavors.

(43) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, enju dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(44) Other hormones, sequestering agents, pH adjusting agents, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetics
Vegetable protein and its degradation product, animal / vegetable polysaccharide and its degradation product, animal / vegetable glycoprotein and its degradation product, blood flow promoter, anti-inflammatory / anti-inflammatory / anti-allergic agent, wound healing agent, A foaming agent, a thickening agent, an enzyme, purified water (electronic water, small clusters, etc.), an oral preparation, a deodorant / deodorant, a bittering agent, etc. can be used. Additive or synergistic improvements in other cosmetic effects can be expected.

Regarding the method for adding the elastase activity inhibitor of the present invention to the cosmetic composition, it may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability. good.

[0074]

EXAMPLES Hereinafter, production examples, test examples and prescription examples will be described, but the present invention is not limited thereto.

(Manufacturing Example 1) 100 g of various dried plants of Tormentilla, Nezu and Forsythia were heated and extracted with purified water (about 80 ° C.) for about 5 hours and filtered to extract (dry solid content: about 0.1 to
2.5%) about 1.0 kg.

(Manufacturing Example 2) 100 g of various dried plants of Tormentilla, Nez and Forsythia were immersed in a 50% ethanol solution, extracted at room temperature for 5 days and night, and then filtered to obtain an extract (dry solid content: about 0.1 to 2.5). %) About 1.0 kg.

(Production Example 3) 100 g of various dried plants such as Tormentilla, Nezu, and Astragalus are 70% ethanol solution or 70%
It is immersed in a 1,3-butylene glycol solution, or a 60% propylene glycol solution, or purified water (about 30 ° C), extracted at room temperature for 5 days and night, and then filtered to extract (dry solid content: about 0.
1-3.0%) about 1.0 kg.

(Test 1) Elastase activity inhibition test "Testing method and evaluation method" For the elastase activity inhibiting action of various plant extracts, pancreatic elastase and a synthetic substrate N-succinyl-ala-ala-ala-p-nitroanilde were used. Evaluated. The substrate was adjusted to 0.1 M with dimethyl sulfoxide, and a 1 mM solution diluted 100-fold with a buffer was used. The enzyme was adjusted to 0.05 unit / mL with a buffer solution. 100 μL of the substrate was reacted with 50 μL of the enzyme and 50 μL of the inhibitor (sample) at 37 ° C. for 30 minutes, then the absorbance was measured at 405 nm, and the inhibition rate was calculated by the following formula 1. The buffer is 0.05M Tris-HCl buffe.
r (pH 8.8) was used and the results are shown in FIG. a. Samples The samples for the elastase activity inhibition test were subjected to the test using the extract obtained in Production Example 2 of the present invention (solid content concentration: adjusted to 0.05%). As a comparative control, dipotassium glycyrrhizinate was used at the same concentration.

<Equation 1> Elastase activity inhibition rate (%) = 100− (in the presence of inhibitor / without inhibitor) × 100

(Test Results) As shown in FIG. 1, it was confirmed that the various plant extracts of Tormentilla, Nezu and Forsythia of the present invention have an effect of significantly suppressing the elastase activity, and can be used as an elastase activity inhibitor.

(Test 2) Safety test (1) Primary skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were prepared with purified water so that the dry solid content concentration was about 0.5%. It was applied to the skin of a Japanese white rabbit whose female back was shaved (female, 3 animals per group, weight 2.3 kg). Evaluation was carried out 24, 48, and 72 hours after application using erythema and edema as indices based on the Draize criterion. As a result, no erythema or edema was observed in any of the animals, and it was judged that there was no problem with respect to primary skin irritation.

(Test 3) Safety test (2) Cumulative skin irritation test Similarly, the various plant extracts obtained in Production Examples 1 to 3 were treated with purified water so that the dry solid concentration was about 0.5%. Prepared and shaved back Hartley guinea pigs (female, 1 group 3)
0.5 mL for once a day, 5 times a week on the skin of an animal (body weight: around 320 g)
/ Animal was applied. Application was carried out for 2 weeks and shaving was carried out on the last application day of each week. On the day after each application day and the day after the last application day, evaluation was performed using erythema and edema as indexes based on the Draize criterion. The result is 2 for all animals.
No erythema or edema was observed over the week, and it was judged that there was no problem with cumulative skin irritation.

(Test 4) Safety test (3) Single dose toxicity test The various plant extracts obtained in Production Examples 1 to 3 were adjusted with purified water to a concentration of 12.5%, and 16 mL / mouse / kg amount,
Before the test, it was orally administered to ddy mice (male and female, 5 mice per group, 5 weeks old) that had been fasted for 4 hours, and the expression and degree of toxic symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days, and the results of autopsy were also abnormal. Therefore, the LD50 was 2,000 mg / kg or more, and it was determined to be a safe substance.

(Formulation Example) Production of Elastase Activity Inhibitor and Cosmetic Composition The formulation examples are shown below according to the above evaluation results. Each formulation example may be one produced by a conventional method in the production of each product. , Only the blending amount is shown. Further, the present invention is not limited to these.

[0085] (Prescription example 1) Emulsion                                                               mass%     1. Squalane 5.0     2. Olive oil 5.0     3. Jojoba oil 5.0     4. Cetyl alcohol 1.5     5. Glycerin monostearate 2.0     6. Polyoxyethylene (20) cetyl ether 3.0     7. Polyoxyethylene (20) soorbitan monooleate 2.0     8.1,3-butylene glycol 1.0     9. Glycerin 2.0    10.A: Tormentilla extract of Production Example 2       B: Nezu extract of Production Example 2       C: Astragalus sinensis extract of Production Example 2       * Any one of A to C extract 5.0    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume proper amount    13. Residue to make purified water 100

[0086] (Prescription example 2) Emulsion mass%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Glyceryl p-aminobenzoate 1.0     4. Ethyl urocanate 1.0     5. Vitamin C phosphate magnesium salt 1.0     6. Cetyl alcohol 1.5     7. Glycerin monostearate 2.0     8. Polyoxyethylene (20) cetyl ether 3.0     9. Polyoxyethylene (20) soorbitan monooleate 2.0    10.1,3-butylene glycol 1.0    11. Glycerin 2.0    12.1,2-Pentanediol 3.0    13. Tormentilla Extract 2.0 of Production Example 1    14. Nezu extract 2.0 of Production Example 1    15. Astragalus Radix Extract 2.0 of Production Example 1    16. Hypericum leaf or stem 70% ethanol extract 1.0    17. Purple root 50% propylene glycol extract 1.0    18. Silk protein enzymatic degradation solution 1.0    19. Pork placenta water extract 1.0    20. Antibacterial / antiseptic agent (paraoxybenzoic acid ester)    21. Residue to make purified water 100

[0087] (Prescription example 3) Cosmetic oil mass%     1. Liquid paraffin 30.0     2. Squalane 20.0     3. Olive oil 20.0     4. Isopropyl palmitate 10.0     5. Tormentilla Extract 3.0 of Production Example 1     6. Clove bud hot water extract 1.0     7. Grapefruit fruit or leaf hot water extract 1.0     8. Tochu leaf hot water extract 1.0     9. Soybean seed hot water extract 1.0    10. Olive oil 1.0    11. Shea butter 1.0    12.Butyl hydroxyanisole 0.1    13. Vitamin E derivative 0.1    14. Antibacterial / antiseptic (benzalkonium chloride)    15. Perfume (Rose water) Appropriate amount    16. Residue to make purified water 100

[0088] (Formulation Example 4) Flexible lotion mass%     1. Glycerin 5.0     2.1,3-butylene glycol 5.0     3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0     4. Ethanol 15.0     5. Tormentilla rhizome 60% 1,3-butylene glycol extract 2.0     6. Astragalus whole plant 60% 1,3-butylene glycol extract 2.0     7. Bodhi flower or fruit 50% 1,3-butylene glycol extract 1.0     8. Yuzu fruit 30% ethanol extract 1.0     9. Sansho peel or fruit 30% 1,2-pentanediol extract 1.0    10. Kiwi fruit 50% ethanol extract 1.0    11. Antibacterial (lactoferrin solution)    12. Antibacterial / antiseptic agent (paraoxybenzoic acid ester)    13. Perfume (Western light water) Suitable amount    14. Purified water 100 residue

[0089] (Prescription example 5) Astringent lotion mass%     1. Sorbit 2.0     2.POE (20) oleyl alcohol 1.0     3. Ethanol 15.0     4.1,2-Pentanediol 3.0     5. 50% Propylene Glycol Extract Solution for Nezu Fruit or Cones 3.0     6. Whole grass 50% ethanol extract 2.0     7. Soaproot leaves 50% 1,3-butylene glycol extract 2.0     8. Gentian whole plant 50% ethanol extract 2.0     9. Hamamelis leaf or bark 50% 1,3-butylene glycol extract 1.0    10. Pepper peel or fruit 30% ethanol extract 1.0    11. Cucumber fruit 50% propylene glycol extract 1.0    12. Yeast 50% 1,3-butylene glycol extract 1.0    13. Allantoin 0.2    14. Astringent (zinc sulfocarbonate) 0.2    15. Antibacterial and antiseptic (thiamin lauryl sulfate)    16. Perfume (lavender water) Suitable amount    17. Residue to make purified water 100

[0090] (Prescription example 6) Two-layer type lotion (liquid-liquid type) mass%     1. Squalane 8.0     2. POE sorbitan tetraoleate 0.3     3. Sorbitol 1.0     4. Ethanol 15.0     5. Tormentilla fruit 70% propylene glycol extract 3.0     6. Nez fruit 70% propylene glycol extract 3.0     7. Astragalus fruit or seed 70% propylene glycol extract 3.0     8. Oolong tea leaf or stem 70% ethanol extract 2.0     9. Red radish rhizome or root bark 50% propylene glycol extract 2.0    10. Green tea leaf or stem 50% 1,3-butylene glycol extract 2.0    11. Sage whole plant 50% ethanol extract 1.0    12. Western Bodhi flower or fruit 30% ethanol extract 1.0    13. Ascorbic acid glucoside 0.2    14. Astringent (calamine) 0.1    15. Antibacterial and antiseptic (phenoxyethanol)    16. Perfume (apple water)    17. Residue to make purified water 100

[0091] (Prescription example 7) Carmine lotion (liquid to solid) mass%     1. Glycerin 3.0     2.1,3-butylene glycol 5.0     3. Ethanol 15.0     4. Iron oxide (red iron oxide) 0.2     5. Zinc oxide 0.5     6. Kaolin 2.0     7. Tormentilla root 30% propylene glycol extract 3.0     8. 50% Propylene Glycol Extract of Nez concha 3.0     9. Peony root 50% propylene glycol extract 2.0    10. Water mallow flower or leaf 50% propylene glycol extract 2.0    11. Chamomile flower 50% propylene glycol extract 2.0    12. Comfrey leaf and stem 50% ethanol extract 1.0    13. Coltsfoot flowers or leaves 50% 1,3-butylene glycol extract 1.0    14. Pig placenta enzyme decomposition solution 1.0    15. Silk protein alkaline solution 2.0    16. Camphor 0.2    17. Phenol 0.03    18. Antibacterial / antiseptic agent (photosensitive element 201 & 401)    19. Perfume (bodhi water) Suitable amount    20. Residue of purified water 100

[0092] (Prescription example 8) Pack mass%     1. Polyvinyl alcohol 15.0     2. Carboxymethyl cellulose sodium 5.0     3. Propylene glycol 3.0     4. Ethanol 10.0     5. Tormentilla Extract of Production Example 2 1.5     6. Nezu extract of Production Example 2 1.5     7. Astragalus Radix Extract 1.5 of Production Example 2     8. Ginseng root 30% ethanol extract 1.0     9. Grape stem or leaf 30% ethanol extract 1.0    10. Unshu mandarin orange peel 50% 1,3-butylene glycol extract 1.0    11. Green tea leaf hot water extract 1.0    12. Peach leaf hot water extract 1.0    13. Yeast 50% 1,3-butylene glycol extract 1.0    14. Pork placenta hot water extract 1.0    15. Antibacterial and antiseptic (paraoxybenzoic acid ester)    16. Perfume (Rose water) Suitable amount    17. Residue to make purified water 100

[0093] (Prescription example 9) Peel-off pack mass%     1. Glycerin 5.0     2. Propylene glycol 4.0     3. Polyvinyl alcohol 15.0     4. Ethanol 8.0     5. Polyoxyethylene glycol 1.0     6. Pantothenyl ethyl ether 1.0     7. Tormentilla root 50% 1,2-butylene glycol extract 3.0     8. 50% glycerin extract solution of flower or fruit spike 2.0     9. Safflower whole plant 50% ethanol extract 1.0    10. Dutch jelly (parsley) leaf or stem 50% ethanol extract 1.0    11. Eucalyptus leaf or stem 30% ethanol extract 1.0    12. Royal jelly 50% ethanol extract 1.0    13. Trehalose solution 1.0    14. Antibacterial and antiseptic (paraoxybenzoic acid ester)    15. Perfume (Chamomile water) Suitable amount    16. Residue to make purified water 100

[0094] (Prescription example 10) Cold cream mass%     1. White beeswax 11.0     2. Liquid paraffin 22.0     3. Lanolin 10.0     4. Olive oil 5.0     5. Chamomile oil 5.0     6. Palm oil 5.0     7. Borax 0.5     8.A: Tormentilla extract of Production Example 2       B: Nezu extract of Production Example 2       C: Astragalus sinensis extract of Production Example 2       * Any one of A to C extract 5.0     9. Achillea millefolium extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    10. White birch bark extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    11. Ginseng root 50% propylene glycol extract 2.0    12. Matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0    13. Soybean seed water extract 1.0    14. Yeast 50% 1,3-butylene glycol extract 2.0    15. Liquid shea fat 1.0    16. Dipotassium glycyrrhizinate 0.1    17. Antibacterial and antiseptic (acrinol) 0.1    18. Perfume (Ylang-Ylang water) Suitable amount    19. Residue to make purified water 100

[0095] (Formulation example 11) Emollient cream mass%     1. Stearic acid 2.0     2. Stearyl alcohol 7.0     3. Reduced lanolin 2.0     4. Squalane 5.0     5. Octyldodecanol 6.0     6. Polyoxyethylene cetyl ether (25E.O.) 3.0     7. Lipophilic glyceryl monostearate 2.0     8. Propylene glycol 2.0     9.1,2-Pentanediol 2.0    10. Nez branch or rhizome 50% propylene glycol extract 2.0    11. Astragalus flower or leaf 50% dipropylene glycol extract 2.0    12. Shiso leaf 50% propylene glycol extract 2.0    13. Purple root 50% propylene glycol extract 2.0    14. Soybean seed fermented soybeans 1.0    15. Glycyrrhetinic acid 0.1    16. Pig placenta enzyme decomposition solution 1.0    17. Antibacterial (lactoferrin solution) 0.5    18. Antibacterial and antiseptic (Zinc pyridione)    19. Perfume (clove water)    20. Residue of purified water 100

[0096] (Prescription example 12) Face wash cream Mass%     1. Myristic acid 25.0     2. Stearic acid 5.0     3. Beef tallow fatty acid 5.0     4. Propylene glycol 10.0     5. Potassium hydroxide 6.0     6. Coconut oil fatty acid diethanolamide 6.0     7. Tormentilla Extract 2.0 of Production Example 2     8. Nezu extract 2.0 of Production Example 2     9. Astragalus extract 2.0 of Production Example 2    10. Apple fruit 20% 1,3-butylene glycol extract 1.0    11. Rosehip fruit 30% ethanol extract 1.0    12.Kakkon hot water extract 1.0    13. Burdock root 50% 1,3-butylene glycol extract 1.0    14. Glycyrrhizic acid 1.0    15. Apricot kernel 0.1    16. Walnut shell grain 0.1    17. Antibacterial and antiseptic (2-phenoxyethanol) 0.1    18. Perfume (tokimizu) Appropriate amount    19. Residue to make purified water 100

[0097] (Prescription example 13) Face-wash cream mass%     1. Stearic acid 10.0     2. Palmitic acid 10.0     3. Myristic acid 12.0     4. Lauric acid 4.0     5. Glycerin 18.0     6. Sodium dl-pyrrolidonecarboxylate 1.0     7. Dioctyl adipate 1.0     8. Cetostearyl alcohol 3.0     9. Triethanolamine 3.0    10. Ergocalciferol 1.0    11. Oleyl alcohol 1.5    12. Lanolin derivative (EO adduct) 1.0    13. Potassium hydroxide 6.0    14.A: Tormentilla extract of Production Example 2       B: Nezu extract of Production Example 2       C: Astragalus sinensis extract of Production Example 2       * Any one of A to C extract 3.0    15. Royal Jelly Extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    16. Oil-soluble chamomile flower or leaf extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    17. Oil-soluble licorice root or rhizome extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    18. Edetate 1.0    19. Glycyrrhetinic acid 1.0    20. Corn cob grain 0.1    21. Walnut shell grain 0.1    22. Antibacterial / antiseptic agent (photosensitive element 401) 0.1    23. Perfume (Mugwort water)    24. Residue to make purified water 100

[0098] (Prescription example 14) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Alkanediol 1.0     5. Whole plant 50% dipropylene glycol extract 4.0     6. Seaweed and kelp 70% 1,3-butylene glycol extract 0.5     7. Armchair leaf or stem 70% 1,3-butylene glycol extract 0.5     8. Soybean seed fermented natto fermentation liquid 0.5     9. Loquat leaf 50% dipropylene glycol extract 0.5    10. Mackerel crape myrtle leaf 20% 2,3-butylene glycol extract 0.5    11. Aloe pulp end 1.0    12. Polyethylene powder 0.5    13. Hydroxypropyl chitosan solution 0.5    14. Amino acids (arginine, glycine, glutamine, etc.) 0.5    15. Monoammonium glycyrrhizinate 0.1    16. Antibacterial / antiseptic (undecylenic acid, phenol)    17. pH adjuster    18. Perfume (lavender water) Suitable amount    19. Residue to make purified water 100

[0099] (Prescription example 15) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Tormentilla whole plant 70% 2,3-butylene glycol extract 3.0     5. Astragalus whole plant 70% 2,3-butylene glycol extract 3.0     6. Toki rhizome 70% 2,3-butylene glycol extract 0.5     7.Kakkon 70% 1,3-butylene glycol extract 0.5     8. Chlorella 70% 1,3-butylene glycol extract 0.5     9. Hydrolyzed collagen solution derived from fish (salmon or flounder) 0.5    10. Psyllium whole plant 50% ethanol extract 0.5    11. Amino acids (glutamine, proline, lysine, etc.) 0.5    12. Monoammonium glycyrrhizinate 0.1    13. Antibacterial and antiseptic (undecylenic acid, phenoxyethanol)    14. pH adjusting agent    15. Perfume (orange water)    16. Residue to make purified water 100

[0100] (Prescription example 16) Sunscreen cosmetics (O / W type) Mass%     1. Oxybenzone 2.0     2. Octyl para methoxycinnamate 5.0     3.Dihydroxymethoxybenzophenone 0.2     4. Squalane 10.0     5. Vaseline 5.0     6. Stearyl alcohol 3.0     7. Stearic acid 3.0     8. Glyceryl monostearate 2.0     9. Polyethyl acrylate 1.0    10.1,3-butylene glycol 6.0    11. Disodium edetate 0.1    12. Triethanolamine 1.0    13. Titanium dioxide 5.0    14. Tormentilla whole plant 50% ethanol extract 3.0    15. Gentian whole plant 50% ethanol extract 1.0    16. White birch bark 70% dipropylene glycol extract 1.0    17. Cornflower leaf 50% propylene glycol extract 0.5    18.Kakkon 50% propylene glycol extract 0.5    19. Yuzu fruit 50% dipropylene glycol extract 0.5    20. Antibacterial and antiseptic (benzyl paraoxybenzoate)    21. Fragrance (jasmine water) Suitable amount    22. Residue of purified water 100

[0101] (Prescription example 17) Sunscreen cosmetics (oil type) Mass%     1. Liquid paraffin 70.0     2. Tetrahydroxybenzophenone 1.0     3. Cetyl octanoate 23.8     4.A: Tormentilla extract of Production Example 2       B: Nezu extract of Production Example 2       C: Astragalus sinensis extract of Production Example 2       * Any one of A to C extract 3.0     5. Chamomile flowers 10% 1,3-butylene glycol extract 1.0     6. Burdock root hot water extract 0.5     7. Horse chestnut whole plant 30% 1,3-butylene glycol extract 0.5     8. Mallow flower or leaf 50% propyl alcohol extract 0.5     9. Whole pearl barley 50% 1,3-butylene glycol extract 0.5    10. Peony root or leaf hot water extract 0.5    11. Merilito flower or leaf 70% 1,3-butylene glycol extract 0.5    12.Ethyl paraaminobenzoate 0.2    13. Antioxidant (Butylhydroxytoluene) Suitable amount    14. Perfume (Mixed perfume)

[0102] (Prescription example 18) Cream foundation (O / W type) Mass%     1. Stearic acid 4.0     2. Glycerin monostearate 3.0     3. Cetanol 1.5     4.Isopropyl myristate 7.0     5. Liquid paraffin 10.0     6. White beeswax 3.0     7. Triethanolamine 1.5     8. Glycerin 3.0     9. Bentonite 1.0    10.Titanium oxide 8.0    11.2,4-Dihydroxybenzophenone 8.0    12. Kaolin 3.0    13. Talc 3.0    14. Coloring pigment (yellow iron oxide) 1.0    15. Tormentilla whole plant 70% 2,3-butylene glycol extract 1.0    16. Whole plant 70% 1,2-Pentanediol extract 1.0    17. Dokudami leaf hot water extract dry powder 0.3    18. Yukinoshita whole plant hot water extract dry powder 0.3    19. Rhizophora rhizome or root bark 50% ethanol extract 0.3    20. Antibacterial and antiseptic (phenoxyethanol) 0.1    21. Perfume (Rose water) Suitable amount    22. Residue of purified water 100

[0103] (Prescription example 19) Shampoo mass%     1. Lauryl sulfate triethanolamine 5.0     2. Sodium polyoxyethylene lauryl ether sulfate 12.0     3.1,3-butylene glycol 4.0     4. Lauric acid diethanolamide 2.0     5. Disodium edetate 0.1     6.A: Tormentilla extract of Production Example 2       B: Nezu extract of Production Example 2       C: Astragalus sinensis extract of Production Example 2       * Any one of A to C extract 3.0     7. Mackerel clover 20% 2,3-butylene glycol extract 2.0     8. Hot water extract of root bark or rhizome 2.0     9. Iris flowers or rhizome 30% 1,4-butylene glycol extract 2.0    10. Toki root 30% 1,4-butylene glycol extract 2.0    11. Hot water extract of tomato fruit 1.0    12. Hydroxypropyl chitosan solution 1.0    13. Hyaluronic acid solution 1.0    14. Dipotassium glycyrrhizinate 0.1    15. Antibacterial and antiseptic (photosensitive element 101)    16. pH adjuster    17. Perfume (sandalwood water)    18. Purified water

[0104] (Prescription example 20) Rinse mass%     1. Stearyl trimethyl ammonium chloride 3.0     2. cetostearyl alcohol 3.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5.1,2-Pentanediol 2.0     6. Tormentilla rhizome or root bark 50% 1,2-pentanediol extract 3.0     7. Astragalus leaf 50% 2,3-butylene glycol extract 3.0     8. Lemongrass 50% 1,2-pentanediol extract 1.0     9. Scented flower 50% 1,3-butylene glycol extract 1.0    10. Mackerel fruit 30% 1,2-butylene glycol extract 1.0    11. Yellow rhizome 50% 1,3-butylene glycol extract 1.0    12. Comfrey leaf or stem 50% 1,3-butylene glycol extract 1.0    13. Soybean seed fermented soybeans 0.5    14. Hydroxyethyl chitosan solution 0.5    15. Hydrolyzed collagen solution derived from fish (salmon or tuna) 0.5    16. Trehalose solution 0.5    17. Hydrolyzed silk solution 0.5    18. Antibacterial / antiseptic (benzalkonium chloride)    19. Fragrance (grape water) Suitable amount    20. Residue of purified water 100

[0105] (Prescription example 21) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Ethylene glycol 3.0     6. Nezu fruit 50% 1,2-pentanediol extract 3.0     7. Astragalus seed 50% 1,2-pentanediol extract 3.0     8. Soaproot leaves 50% 1,3-butylene glycol extract 1.0     9. Western Bodhi flower or fruit 50% 1,4-butylene glycol extract 1.0    10. Olive leaf 50% 1,2-butylene glycol extract 1.0    11. Loquat leaf 50% ethanol extract 1.0    12. Centipede fruit or flower 50% 1,3-butylene glycol extract 1.0    13. Sweet green tea 50% glycerin extract 1.0    14. Bifidobacterium fermentation liquid 1.0    15. Sodium alginate 1.0    16. Trehalose solution 1.0    17. Hydrolyzed keratin solution 1.0    18. Antibacterial / antiseptic (benzalkonium chloride)    19. Perfume (Chamomile water) Suitable amount    20. Residue of purified water 100

[0106] (Formulation Example 22) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Tormentilla rhizome 50% 1,3-butylene glycol extract 3.0     6. Apricot fruit 50% glycerin extract 1.0     7. Hop female spike 50% ethanol extract 1.0     8. Melissa whole plant 50% ethanol extract 1.0     9. Usubasaicin rhizome 30% ethanol extract 1.0    10. White birch sap 1.0    11. Carpronium chloride 0.3    12. Hinokitiol 0.5    13. Keratin decomposition solution 0.5    14. Stearyl glycyrrhetinate 0.1    15. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    16. Perfume (Rosehip water) Suitable amount    17. Residue to make purified water 100

[0107] (Formulation Example 23) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5.1,2-hexanediol 1.0     6. 50% 1,2-butylene glycol extract of allium root extract 3.0     7. Nezu leaf 50% 1,3-butylene glycol extract 3.0     8. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0     9. Ginseng root hot water extract 1.0    10. Apple fruit 30% ethanol extract 1.0    11. Sesamorin 0.3    12. Azulene 1.0    13. Antibacterial / antiseptic (paraben, benzalkonium chloride) appropriate amount    14. Perfume (orange water) Suitable amount    15. Residue to make purified water 100

[0108] (Formulation Example 24) Hair liquid mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4.A: Tormentilla extract of Production Example 2       B: Nezu extract of Production Example 2       C: Astragalus sinensis extract of Production Example 2       * Any one of A to C extract 6.0     5. Comfrey leaf or stem 50% ethanol extract 1.0     6. Yuzu fruit or leaf 50% ethanol extract 1.0     7. Soybean seed natto fermented liquid 1.0     8. Hamamelis leaf or stem hot water extract 1.0     9. Comfrey leaf or stem 50% ethanol extract 1.0    10. Loquat leaf 30% ethanol extract 1.0    11. Lettuce leaf 50% ethanol extract 1.0    12. Carpronium chloride 0.3    13. Pantethine solution 0.3    14. Amino acids or their derivatives 3.0     (Lysine, alanine, pyrrolidone carboxylic acid, etc.)    15. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    16. Perfume (Rose water) Suitable amount    17. Residue to make purified water 100

[0109] (Prescription example 25) Heartonic mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4. Nezu cone or fruit 30% ethanol extract 3.0     5. Clove leaf 30% ethanol extract 1.0     6. Antibacterial / antiseptic (propyl paraoxybenzoate) 0.2     7. Residue to make purified water 100

[0110] (Prescription example 26) Heartonic mass%     1.l-menthol 0.2     2. Ethanol 32.5     3. Polyoxyethylene hydrogenated castor oil 0.5     4. Propylene glycol 5.0     5. Diphenhydramine hydrochloride 0.3     6.A: Tormentilla extract of Production Example 2       B: Nezu extract of Production Example 2       C: Astragalus sinensis extract of Production Example 2       * Any one of A to C extract 3.0     7. Hypericum perforatum fruit or pericarp hot water extract 1.0     8. Western Bodhi flower or leaf 50% propylene glycol extract 1.0     9. Lavender flower or flower spike hot water extract 1.0    10. Bildo Aoi rhizome or root bark 50% ethanol extract 1.0    11. Auregon rhizome or root bark 50% ethanol extract 1.0    12. Soybean seed hot water extract 1.0    13. Carboxymethyl chitin solution 1.0    14. Chicken comb extract solution 0.2    15. Pantethine solution 0.2    16. Antibacterial / antiseptic (phenoxyethanol)    17. Perfume (Rose water) Suitable amount    18. Residue to make purified water 100

[0111] (Prescription example 27) Hair growth and hair nourishing agent% by mass     1.Ethanol 60.0     2. Tormentilla root 50% glycerin extract 5.0     3. 50% Propylene Glycol Extract Liquid     4. Vitamin E derivative 0.5     5. Capsicum tincture 0.5     6. Resorcin 0.5     7.Dipotassium glycyrrhizinate 0.5     8. Carboxymethyl chitin solution 0.5     9. Collagen protein enzymatic degradation solution 1.0    10. Pig hematin solution 0.5    11. Pork mucin solution 0.5    12. Amino acids (arginine, glycine, glutamine, etc.) 0.5    13. Antibacterial and antiseptic (paraben) 0.1    14. Perfume (rosemary water) Suitable amount    15. Residue to make purified water 100

[0112] (Prescription example 28) Hair growth and hair nourishing agent% by mass     1.Ethanol 60.0     2.A: Tormentilla extract of Production Example 2       B: Nezu extract of Production Example 2       C: Astragalus sinensis extract of Production Example 2       * Any one of A to C extract 3.0     3. Hot water extract of rhizome root bark or rhizome 3.0     4. Whole plant 60% ethanol extract 3.0     5. Peony rhizome or root bark 60% ethanol extract 3.0     6. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0     7. Soybean seed natto fermented liquid 1.0     8. Whole clover 20% 2,3-butylene glycol extract 1.0     9. Pepper fruit hot water extract 1.0    10. Cantharis tincture 0.5    11. Pantothenic acid derivative 0.2    12.β-glycyrrhetinic acid 0.2    13. Resorcin 0.2    14. Hydroxyethyl chitosan solution 0.2    15. Elastin hydrolyzate 0.2    16.Keratin protein enzymatic degradation solution 0.2    17. Preservative (paraben) 0.1    18. Perfume (Bergamot water) Suitable amount    19. Residue to make purified water 100

[0113] (Prescription example 29) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 5.0     4.A: Tormentilla extract dry powder of Production Example 1       B: Nez extract dry powder of Production Example 1       C: Astragalus sinensis extract of Production Example 2       * Any one of A to C extract dry powder 3.0     5. Sorbitol 1.0     6. Peach leaf 70% ethanol extract dry powder 1.0     7. Black tea leaf 30% ethanol extract dry powder 1.0     8. Mulberry bark hot water extract dry powder 1.0     9. Dye (Gunzhou Green) Appropriate amount

[0114] (Formulation example 30) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 3.0     4. Hyaluronic acid powder 3.0     5. Tormentilla fruit hot water extract dry powder 1.0     6. Nez fruit hot water extract dry powder 1.0     7. Astragalus seed hot water extract dry powder 1.0     8. Sambucus nigra flower or berries hot water extract dry powder 1.0     9. Orange peel 50% ethanol extract 1.0    10. Apple juice powder 1.0    11. Dye (Gunjou, Chromium hydroxide) Appropriate amount    12. Perfume (grape water) Suitable amount

(Formulation Example 31) Coat protective agent Gauze or liniment cloth is impregnated with a formulation solution in which an appropriate amount of tormentilla rhizome or whole plant of roots or whole lotus root plant hot water extract, antibiotics, anti-inflammatory agents, etc. is impregnated and wounded. Attached to the department. Alternatively, the hot water extract of tormentilla rhizome or whole plant of roots or whole plant of Astragalus sinensis may be directly sprayed locally and covered with gauze or the like.

[0116] (Prescription example 32) Toothpaste                                                              mass%     1. Silicic anhydride 20.0     2.Sorbit solution 50.0     3. Glycerin 10.0     4. Tormentilla fruit or seed hot water extract 5.0     5. Nezu fruit or seed hot water extract 5.0     6. Sodium lauryl sulfate 2.0     7. Saccharin sodium 0.05     8. Sodium carboxymethyl cellulose 1.5     9. Fragrance (cardamom water)    10. Appropriate amount of colorant    11. Purified water

[0117] (Prescription example 33) Oral cooling agent Mass%     1. Ethanol 20.0     2. Glycerin 15.0     3. Polyoxyethylene hydrogenated castor oil 1.0     4. Saccharin 0.2     5.Chlorhexidine 0.01     6.A: Tormentilla rhizome or root bark hot water extract       B: Hot water extract of fruit or pericarp       C: Hot Spring Extract of Astragalus sinensis       * Any one of A to C extract 3.0     7. Hypericum leaf or stem hot water extract 1.0     8. Grapefruit fruit or leaf hot water extract 1.0     9. Green tea leaf hot water extract dry powder 0.1    10. Dye (Gunzhou Green) Appropriate amount    11. Residue to make purified water 100

[0118] (Prescription example 34) Dish detergent for mass%     1. Alkyl (C12) glucoside 20.0     2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0     3. Glycerin 2.0     4. Ethanol 5.0     5. Astragalus leaf or stem hot water extract 3.0     6. Hot water extract of dried root bark of Hyogi 1.5     7. Sandalwood whole plant 50% dipropylene glycol extract 0.5     8. Residue to make purified water 100

(Test 5) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. Use test is for healthy adult women 25 ~
30 people each 50 years old will be panelists, and there will be 2 daily mornings and evenings.
After washing the face and washing the face, an appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 3 months. As a control, an emulsion prepared by removing various plant extracts of the present invention and formulated by the same method was used. The evaluation method was carried out according to the following criteria, and the results are shown in Table 1 and the numerical values in the table represent the number of people.
No one complained of skin abnormality during the period of use.

[Effect of skin tension and luster improvement] Effective: Increased skin tension and gloss. Slightly effective: Skin tension and luster slightly increased. Ineffective: No change from before use.

[Effect of Wrinkle / Talmi Improvement of Skin] Effective: Wrinkles and tarmi on the skin are less noticeable. Slightly effective: Wrinkles and tarmi on the skin became slightly less noticeable. Ineffective: No change from before use.

[0122]

[Table 1]

(Test Results) As shown in Table 1, the cosmetic composition containing the Tormentilla, Nezu and Astragalus extract of the present invention significantly gives the skin firmness and luster, and also reduces wrinkles and tarmi of the skin. I was able to confirm that.

[0124]

Industrial Applicability The elastase activity inhibitor or cosmetic composition containing one or more kinds of plant extracts selected from tormentilla, Nez, and Astragalus japonicus of the present invention has an elastase activity inhibitory effect, and also to the skin. It gives tension and luster, and can further improve wrinkles and tarmi. Therefore, it is effective in preventing skin aging and can be applied to preparations in any form (medicines, quasi drugs, cosmetics). It can also be used for other general foods and drinks.

[Brief description of drawings]

FIG. 1 is a diagram showing the elastase activity inhibition rate of dipotassium glycyrrhizinate at the same concentration as various plant extracts of Tormentilla, Nez, and Astragalus of the present invention and as a comparative control.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/00 A61K 7/00 N U 7/035 7/035 7/06 7/06 7/075 7 / 075 7/16 7/16 7/42 7/42 7/48 7/48 7/50 7/50 A61P 43/00 111 A61P 43/00 111 F term (reference) 4C083 AA072 AA082 AA111 AA112 AA122 AB032 AB052 AB152 AB212 AB232 AB242 AB312 AB352 AB432 AB442 AC012 AC022 AC072 AC122 AC132 AC172 AC182 AC242 AC342 AC422 AC432 AC442 AC472 AC482 AC522 AC542 AC552 AC582 AC612 AC642 AC682 AC692 AC782 AC792 AC852 AC862 AC932 AD022 AD042 AD092 AD512 AD112 AD452 AD532 AD512 AD512 AD432 AD392 AD412 AD642 AD652 AD662 CC01 CC02 CC04 CC05 CC07 CC19 CC23 CC25 CC32 CC33 CC37 CC38 CC39 CC41 DD16 DD21 DD22 DD23 DD27 DD30 DD31 DD33 EE12 EE21 4C088 AB03 AB51 AB59 AC01 AC03 AC04 AC05 AC06 A C11 AC13 BA07 BA08 MA63 ZA89 ZC20

Claims (2)

[Claims] 1. An elastase activity inhibitor comprising one or more plant extracts selected from Tormentilla, Nezu and Astragalus. 2. A cosmetic composition comprising the elastase activity inhibitor according to claim 1.