JP2003002820A - Skin care composition - Google Patents
Skin care compositionInfo
- Publication number
- JP2003002820A JP2003002820A JP2001189708A JP2001189708A JP2003002820A JP 2003002820 A JP2003002820 A JP 2003002820A JP 2001189708 A JP2001189708 A JP 2001189708A JP 2001189708 A JP2001189708 A JP 2001189708A JP 2003002820 A JP2003002820 A JP 2003002820A
- Authority
- JP
- Japan
- Prior art keywords
- genus
- belonging
- glycosides
- plants
- plant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 241000196324 Embryophyta Species 0.000 claims abstract description 77
- 229930182470 glycoside Natural products 0.000 claims abstract description 35
- 150000002338 glycosides Chemical class 0.000 claims abstract description 35
- 239000000284 extract Substances 0.000 claims abstract description 24
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- 239000000843 powder Substances 0.000 claims abstract description 9
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- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 claims abstract description 5
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- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 claims description 4
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- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 claims description 4
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Landscapes
- Cosmetics (AREA)
Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、植物抽出物を配合
した抗老化化粧料に関し、さらに詳しくはエラスターゼ
阻害作用を有し、皮膚のハリや弾力を保持し、若々しい
肌の状態を維持することのできる抗老化剤に関する。本
発明の抗老化化粧料は基礎化粧品をはじめ、メーキャッ
プ化粧品などに好適に使用しうるものである。TECHNICAL FIELD The present invention relates to an anti-aging cosmetic composition containing a plant extract, and more specifically, it has an elastase inhibitory action, maintains the firmness and elasticity of the skin, and maintains a youthful skin condition. The present invention relates to an anti-aging agent that can be used. INDUSTRIAL APPLICABILITY The anti-aging cosmetic composition of the present invention can be suitably used for basic cosmetics, makeup cosmetics and the like.
【0002】[0002]
【従来の技術および発明が解決しようとする課題】従
来、抗老化化粧料の必要性が考慮されてきていたが、老
化に関するメカニズム、定義などが明らかではなかった
ため、一般的には肌の潤いとして保湿状態の計測や、肌
の弾力の計測を行って判定してきた。ところが近年、老
化に関する研究が進められ、皮膚老化の原因としては第
一には加齢が重要な因子であり、さらに紫外線による影
響が皮膚老化に関わる直接的な因子として挙げられる。
皮膚老化の具体的な現象としては、皮膚真皮におけるコ
ラーゲンやエラスチンの減少、ヒアルロン酸をはじめと
するムコ多糖類の減少、紫外線による細胞の損傷などが
知られている。このうちエラスチンは互いに架橋を作っ
て組織の弾性に寄与しているものであるが、紫外線暴露
や加齢により、エラスチン破壊酵素であるエラスターゼ
が過剰発現することによってエラスチンが変性・破壊さ
れることが皮膚の弾力性低下につながると考えられてい
る。BACKGROUND OF THE INVENTION Conventionally, the necessity of anti-aging cosmetics has been considered, but since the mechanism and definition of aging have not been clarified, it is generally considered as a moisturizing skin. It has been judged by measuring the moisturizing condition and the elasticity of the skin. However, in recent years, research on aging has been advanced, and as a cause of skin aging, aging is the first important factor, and the effect of ultraviolet rays is mentioned as a direct factor relating to skin aging.
As specific phenomena of skin aging, it is known that collagen and elastin in the skin dermis are reduced, mucopolysaccharides such as hyaluronic acid are reduced, and cell damage due to ultraviolet rays is caused. Of these, elastin forms cross-links with each other and contributes to the elasticity of tissues.However, elastin, which is an elastin-disrupting enzyme, is overexpressed by UV exposure and aging, and elastin is denatured and destroyed. It is believed to lead to reduced skin elasticity.
【0003】従って、エラスターゼの働きを抑え、皮膚
に弾力やハリを与えるエラスチンの変性・破壊を防止す
ることが皮膚の老化防止に重要である。ところが、従来
の抗老化化粧料には線維芽細胞を活性化しコラーゲンの
産生量を増加させる機序を持ったものは多く認められる
が、エラスターゼ活性の阻害に着目したものは少ない。Therefore, it is important to prevent aging of the skin by suppressing the action of elastase and preventing the degeneration and destruction of elastin which gives elasticity and firmness to the skin. However, many conventional anti-aging cosmetics have a mechanism of activating fibroblasts and increasing the amount of collagen produced, but few have focused on the inhibition of elastase activity.
【0004】したがって本発明は、エラスターゼの活性
を抑えることにより皮膚の線維成分を保護し、皮膚のハ
リ、弾力を回復・維持することで皮膚の老化を防止し、
若々しい肌の状態を維持する効果を奏する抗老化化粧料
を提供することを目的とする。Therefore, the present invention protects the fiber components of the skin by suppressing the activity of elastase, and prevents the aging of the skin by restoring and maintaining the firmness and elasticity of the skin,
It is an object of the present invention to provide an anti-aging cosmetic which has an effect of maintaining a youthful skin condition.
【0005】[0005]
【課題を解決するための手段】本発明者は、上記課題の
解決に向けて鋭意検討を行った結果、カテキン類および
/又はその配糖体、フラボン類および/又はその配糖
体、フラボノール類および/又はその配糖体、フラバノ
ン類および/又はその配糖体、イソフラボン類および/
又はその配糖体、クマリン類および/又はその配糖体、
フスコポリア(Fuscoporia)属に属するきのこ、ビチス
(Vitis)属、オエノセラ(Oenothera)属、ベリス(Be
llis)属、グナファリウム(Gnaphalium)属、アルクト
スタフィロス(Arctostaphylos)属、セントーレ(Cent
aurea)属、リスラム(Lythrum)属、ヒソップ(Hyssop
us)属、サイムス(Thymus)属、レオントポジウム(Le
ontopodium)属、セントーリー(Centaurium)属、サト
レジャ(Satureja)属、アンスリスカス(Anthriscus)
属、ロールス(Laurus)属、ニンファエア(Nymphaea)
属、シリンガ(Syringa)属、カレンデュラ(Calendul
a)属、トルネラ(Turnera)属、スカビー(Scurvy)
属、トリフォリウム(Trifolium)属、コンバラリア(C
onvallaria)属、コンソロダ(Consolida)属、アルテ
ミシア(Artemisia)属、ガーデニア(Gardenia)属、
カメリア属、シトラス(Citrus)属、アルケミラ(Alch
emilla)属、アルテミシア(Artemisia)属、メンタ(M
enth)属、さらに、マルス(Malus)属に属する植物の
抽出物、および赤ワイン乾燥粉末にエラスターゼ阻害活
性を有することを見出し、本発明を完成するに至った。Means for Solving the Problems As a result of extensive studies aimed at solving the above-mentioned problems, the present inventor has found that catechins and / or their glycosides, flavones and / or their glycosides, and flavonols. And / or a glycoside thereof, a flavanone and / or a glycoside thereof, an isoflavone and / or
Or a glycoside thereof, a coumarin and / or a glycoside thereof,
Mushrooms belonging to the genus Fuscoporia, genus Vitis, genus Oenothera, beris
llis genus, Gnaphalium genus, Arctostaphylos genus, Centre
aurea genus, Lythrum genus, Hyssop
us), Thymus, Leontopodium (Le
genus ontopodium, genus Centaurium, genus Saturja, Anthriscus
Genus, genus Laurus, Nymphaea
Genus, Syringa, Calendul
a) genus, Turnera genus, Scurvy
Genus, genus Trifolium, Convalaria (C
onvallaria), Consolida (Consolida), Artemisia (Artemisia), Gardenia (Gardenia),
Camellia, Citrus, Alchemilla
genus emilla, Artemisia, mentor
The present invention has been completed based on the finding that the extract of plants belonging to the genus enth), the plant belonging to the genus Malus, and the dry powder of red wine have elastase inhibitory activity.
【0006】本発明に用いることの出来る物質及び抽出
物は特に限定されないが、カテキン類および/又はその
配糖体にはカテキン、エピカテキン、エピガロカテキ
ン、エピガロカテキンガレート等が挙げられる。The substances and extracts that can be used in the present invention are not particularly limited, but catechins and / or glycosides thereof include catechin, epicatechin, epigallocatechin, epigallocatechin gallate and the like.
【0007】フラボン類および/又はその配糖体にはル
テオリン、フラボン、アピゲニン等が挙げられる。Examples of flavones and / or their glycosides include luteolin, flavones and apigenin.
【0008】フラボノール類および/又はその配糖体に
はクエルセチン、ミリセチン、ケンフェロール、クエル
シトリン、ルチン等が挙げられる。Examples of flavonols and / or their glycosides include quercetin, myricetin, kaempferol, quercitrin, rutin and the like.
【0009】フラバノン類および/又はその配糖体には
ナリンゲニン、フラバノン、ヘスペリジン、ナリンギン
等が挙げられる。Examples of flavanones and / or glycosides thereof include naringenin, flavanone, hesperidin and naringin.
【0010】イソフラボン類および/又はその配糖体に
はゲニステイン、ダイゼインゲニスチン等が挙げられ
る。The isoflavones and / or their glycosides include genistein, daidzein genistin and the like.
【0011】クマリン類および/又はその配糖体にはエ
スクレチン等が挙げられる。Coumarins and / or glycosides thereof include esculetin and the like.
【0012】フスコポリア(Fuscoporia)属に属するき
のことしては白樺茸(Fuscoporia obliqua)等が挙げら
れる。Examples of mushrooms belonging to the genus Fuscoporia include white birch mushrooms (Fuscoporia obliqua).
【0013】ビチス(Vitis)属植物としてはブドウ(V
itis vinifera L.)等が挙げられる。As a plant of the genus Vitis, grapes (V
itis vinifera L.) and the like.
【0014】オエノセラ(Oenothera)属植物としては
メマツヨイグサ(Oenothera biennis L.)等が挙げられ
る。Examples of plants belonging to the genus Oenothera include evening primrose (Oenothera biennis L.) and the like.
【0015】ベリス(Bellis)属植物としてデイジー
(Bellis perennis)等が挙げられる。Examples of plants of the genus Bellis include Bellis perennis.
【0016】グナファリウム(Gnaphalium)属植物とし
てエバーラスティング(Gnaphaliumuliginosum L.)等
が挙げられる。Examples of the Gnaphalium genus plant include Everlasting (Gnaphalium uliginosum L.) and the like.
【0017】アルクトスタフィロス(Arctostaphylos)
属植物としてウワウルシ(Arctostaphylosuva-ursi(L.)
SPRENG.)等が挙げられる。Arctostaphylos
Arctostaphylosuva-ursi (L.) as a genus plant
S PRENG. ) And the like.
【0018】セントーレ(Centaurea)属植物としてコ
ーンフラワー(Centaureacyanus L.)等が挙げられる。Examples of the plant of the genus Centaurea include cornflower (Centaureacyanus L.) and the like.
【0019】リスラム(Lythrum)属植物としてミソハ
ギ(Lythrum anceps Makino)、グラスポリー(Lythr
um salicaria L.)等が挙げられる。Lythrum (Lythrum) plants include Lythrum anceps Makino and grass polly (Lythr).
um salicaria L.) and the like.
【0020】ヒソップ(Hyssopus)属植物としてヒソッ
プ(Hyssopus officinalis L.)等が挙げられる。Examples of Hyssopus plants include Hyssopus officinalis L. and the like.
【0021】サイムス(Thymus)属植物としてイブキジ
ャコウソウ(Thymus quinquecostatus Celak.)、ワ
イルドタイム(Thymus serpyllum L.)等が挙げられ
る。Examples of the plant of the genus Thymus include Thymus quinquecostatus Celak. And Wild thyme (Thymus serpyllum L.).
【0022】レオントポジウム(Leontopodium)属植物
としてエーデルワイス(Leontopodium alpinum )等が
挙げられる。Examples of plants belonging to the genus Leontopodium include Edelweiss (Leontopodium alpinum) and the like.
【0023】セントーリー(Centaurium)属植物として
セントーリー(Centaurium erythraea RAFN.)等が挙げ
られる。Examples of the plant of the genus Centaurium include Centaurium erythraea R AFN .
【0024】サトレジャ(Satureja)属植物としてサボ
リー(Satureja hortensis L.)等が挙げられる。Examples of the plant of the genus Saturja include savory (Satureja hortensis L.).
【0025】アンスリスカス(Anthriscus)属植物とし
てチャービル(Anthriscus cerefolium(L.)HOFFM.)等
が挙げられる。Examples of plants belonging to the genus Anthriscus include chervil (Anthriscus cerefolium (L.) H OFFM .).
【0026】ロールス(Laurus)属植物としてローレル
(Laurus nobilis L.)等が挙げられる。Examples of the plant of the genus Rolls include Laurel (Laurus nobilis L.) and the like.
【0027】ニンファエア(Nymphaea)属植物としてホ
ワイトウォーターリリー(Nymphaea alba L.)等が挙げ
られる。Examples of the plant of the genus Nymphaea include white water lily (Nymphaea alba L.) and the like.
【0028】シリンガ(Syringa)属植物としてライラ
ック(Syringa vulgaris)等が挙げられる。Examples of plants belonging to the genus Syringa include lilac (Syringa vulgaris).
【0029】カレンデュラ(Calendula)属植物として
ポットマリーゴールド(Calendulaofficinalis)等が挙
げられる。Examples of the plant of the genus Calendula include pot marigold (Calendula officinalis).
【0030】トルネラ(Turnera)属植物としてダミア
ナ(Turnera diffusa WIL LD.varaphrodisiaca(WARD.)U
RB.)等が挙げられる。[0030] Damner (Turnera diffusa W IL LD .varaphrodisiaca (W ARD .) U)
RB .) And the like.
【0031】スカビー(Scurvy)属植物としてスカビー
グラス(Scurvy grass)等が挙げられる。Examples of Scurvy plants include Scurvy grass and the like.
【0032】トリフォリウム(Trifolium)属植物とし
てレッドクローバー(Trifolium pratenseL.)等が挙げ
られる。Examples of plants of the genus Trifolium include red clover (Trifolium pratense L.) and the like.
【0033】コンバラリア(Convallaria)属植物とし
てリリーオブザバリー(Convallaria majalisL.)等が
挙げられる。Examples of plants of the genus Convallaria include Lily of the Barry (Convallaria majalis L.) and the like.
【0034】コンソロダ(Consolida)属植物としてヒ
エンソウ(Consolida ambigua)等が挙げられる。Examples of plants belonging to the genus Consolida include cypress (Consolida ambigua) and the like.
【0035】アルテミシア(Artemisia)属植物として
タラゴン(Artemisiadracunculoildes L.)等が挙げら
れる。Examples of Artemisia plants include tarragon (Artemisia dracunculoildes L.) and the like.
【0036】ガーデニア(Gardenia)属植物としてクチ
ナシ(Gardenia jasminoidesEllis f. grandiflora Mak
ino)等が挙げられる。Gardenia jasminoides Ellis f. Grandiflora Mak as a plant of the genus Gardenia
ino) and the like.
【0037】カメリア属植物としてツバキ(Camellia j
aponicaL.)等が挙げられる。As a Camellia plant, camellia (Camellia j
aponica L.) and the like.
【0038】シトラス(Citrus)属植物としてレモン
(Citrus limon BURM.)等が挙げられる。Examples of Citrus plants include lemon (Citrus limon B URM .) And the like.
【0039】アルケミラ(Alchemilla)属植物としてハ
ゴロモグサ(Alchemillavulgarisagg.)等が挙げられ
る。Examples of Alchemilla genus plants include Alchemilla vulgarisagg.
【0040】アルテミシア(Artemisia)属植物として
シロヨモギ(Artemisiastelleriana Besser)、サザン
ウッド(Artemisia abrotanum L.)等が挙げられる。Examples of Artemisia plants include Artemisia stelleriana Besser and Southern wood (Artemisia abrotanum L.).
【0041】メンタ(Menth)属植物としてウォーター
ミント(Mentha aquaticaL.)、ペニーローヤル(Menth
a pulegium L.)等が挙げられる。As a plant of the genus Menth, water mint (Mentha aquatica L.) and penny royal (Menth)
a pulegium L.) and the like.
【0042】マルス(Malus)属植物としてリンゴ(Mal
us pumila Mill.)、ハナカイドウ(Malus halliana
Koehne)等が挙げられる。As a plant of the genus Malus, apples (Mal
us pumila Mill.), Hana Kaidou (Malus halliana)
Koehne) and the like.
【0043】本発明に用いるカテキン類および/又はそ
の配糖体、フラボン類および/又はその配糖体、フラボ
ノール類および/又はその配糖体、フラバノン類および
/又はその配糖体、イソフラボン類および/又はその配
糖体、クマリン類および/又はその配糖体は、市販の試
薬を使用することが出来る。また、これらの化合物を多
く含有する植物から各種の溶媒、例えば、水;メチルア
ルコール、エチルアルコール等の低級1価アルコール;
グリセリン、プロピレングリコール、1,3−ブチレン
グリコール等の液状多価アルコール;アセトン、メチル
エチルケトン等のケトン;酢酸エチルなどのアルキルエ
ステル;ベンゼン、ヘキサン等の炭化水素;ジエチルエ
ーテル等のエーテル類;ジクロルメタン、クロロホルム
等のハロゲン化アルカン等の1種または2種以上を用い
て抽出し、精製して使用することが出来る。さらには、
化学的な合成によって上記化合物を作成したものを利用
することも可能である。Catechins and / or glycosides thereof, flavones and / or glycosides thereof, flavonols and / or glycosides thereof, flavanones and / or glycosides thereof, isoflavones and As the glycoside, the coumarin and / or the glycoside thereof, commercially available reagents can be used. In addition, various solvents such as water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol, from plants containing a large amount of these compounds;
Liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol; ketones such as acetone and methyl ethyl ketone; alkyl esters such as ethyl acetate; hydrocarbons such as benzene and hexane; ethers such as diethyl ether; dichloromethane, chloroform It is possible to use by extracting with one or more halogenated alkanes and the like, and extracting and purifying. Moreover,
It is also possible to use a product prepared from the above compound by chemical synthesis.
【0044】さらに、フスコポリア(Fuscoporia)属に
属するきのこの使用部位は特に限定されない。子実体、
胞子、菌糸体であっても良い。これらを生のまま或いは
乾燥したものを用いて抽出することが出来る。就中、入
手のしやすさから子実体が好適である。Furthermore, the use site of mushrooms belonging to the genus Fuscoporia is not particularly limited. Fruiting body,
It may be a spore or a mycelium. These can be extracted raw or dried. Of these, fruiting bodies are preferable because they are easily available.
【0045】ビチス(Vitis)属植物、オエノセラ(Oen
othera)属植物、ベリス(Bellis)属植物、グナファリ
ウム(Gnaphalium)属植物、アルクトスタフィロス(Ar
ctostaphylos)属植物、セントーレ(Centaurea)属植
物、リスラム(Lythrum)属植物、ヒソップ(Hyssopu
s)属植物、サイムス(Thymus)属植物、レオントポジ
ウム(Leontopodium)属植物、セントーリー(Centauri
um)属植物、サトレジャ(Satureja)属植物、アンスリ
スカス(Anthriscus)属植物、ロールス(Laurus)属植
物、ニンファエア(Nymphaea)属植物、シリンガ(Syri
nga)属植物、カレンデュラ(Calendula)属植物、トル
ネラ(Turnera)属植物、スカビー(Scurvy)属植物、
トリフォリウム(Trifolium)属植物、コンバラリア(C
onvallaria)属植物、コンソロダ(Consolida)属植
物、アルテミシア(Artemisia)属植物、ガーデニア(G
ardenia)属植物、カメリア属植物、シトラス(Citru
s)属植物、アルケミラ(Alchemilla)属植物、アルテ
ミシア(Artemisia)属植物、メンタ(Menth)属植物、
マルス(Malus)属植物の使用部位は特に限定されず、
それぞれの葉、枝、茎、花、果実、根、種子等或いは、
全草を生のまま或いは乾燥したものを用いて抽出するこ
とが出来る。就中、ビチス(Vitis)属植物、オエノセ
ラ(Oenothera)属植物は種子、マルス(Malus)属植物
は、果実皮が好適である。Vitis genus plant, Oenocera (Oen
othera) plant, Bellis plant, Gnaphalium plant, Arctostaphylos (Ar)
ctostaphylos, Centaurea, Lythrum, Hyssopu
s) genus plant, Thymus genus plant, Leontopodium genus plant, Centauri
um genus plant, Satureja genus plant, Anthriscus genus plant, Laurus genus plant, Nymphaea genus plant, Syringa (Syri)
nga) plants, Calendula plants, Turnera plants, Scurvy plants,
Trifolium genus plant, Convalaria (C
onvallaria plant, Consolida plant, Artemisia plant, Gardenia (G
ardenia plant, Camellia plant, citrus (Citru)
s) plant, Alchemilla plant, Artemisia plant, Menth plant,
The use site of the Malus plant is not particularly limited,
Each leaf, branch, stem, flower, fruit, root, seed, etc., or
The whole grass can be extracted raw or dried. Among them, seeds are preferable for plants of the genus Vitis, plants of the genus Oenothera, and fruit peels are preferable for the plants of the genus Malus.
【0046】本発明に用いる抽出物および赤ワイン乾燥
粉末の調製は特に限定されないが、例えば種々の適当な
有機溶媒を用いて低温下から加温下で抽出される。抽出
溶媒としては、例えば、水;メチルアルコール、エチル
アルコール等の低級1価アルコール;グリセリン、プロ
ピレングリコール、1,3−ブチレングリコール等の液
状多価アルコール;アセトン、メチルエチルケトン等の
ケトン;酢酸エチルなどのアルキルエステル;ベンゼ
ン、ヘキサン等の炭化水素;ジエチルエーテル等のエー
テル類;ジクロルメタン、クロロホルム等のハロゲン化
アルカン等の1種または2種以上を用いることが出来
る。就中、水、エチルアルコール、1,3−ブチレング
リコールの1種または2種以上の混合溶媒が特に好適で
ある。The preparation of the extract and the dry powder of red wine used in the present invention is not particularly limited, but for example, it is extracted from a low temperature to a high temperature using various suitable organic solvents. Examples of the extraction solvent include water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol; ketones such as acetone and methyl ethyl ketone; ethyl acetate and the like. One or more of alkyl esters; hydrocarbons such as benzene and hexane; ethers such as diethyl ether; halogenated alkanes such as dichloromethane and chloroform can be used. Above all, one or a mixture of two or more kinds of water, ethyl alcohol and 1,3-butylene glycol is particularly suitable.
【0047】各抽出物は例えば適当に細かく粉砕し乾燥
したものであれば、赤ワインについては、ワインを蒸発
乾固したものであれば、重量比で1〜1000倍量、特
に10〜100倍量の溶媒を用い、常温抽出の場合に
は、0℃以上、特に20℃〜40℃で1時間以上、特に
3〜7日間行うのが好ましい。また、60〜100℃で
1時間、加熱抽出しても良い。Each extract is, for example, appropriately finely pulverized and dried. For red wine, if wine is evaporated to dryness, the weight ratio is 1 to 1000 times, especially 10 to 100 times. In the case of normal temperature extraction using the above solvent, it is preferable to carry out at 0 ° C. or higher, particularly at 20 ° C. to 40 ° C. for 1 hour or longer, particularly 3 to 7 days. Moreover, you may heat-extract at 60-100 degreeC for 1 hour.
【0048】以上のような条件で得られる上記各抽出物
は、抽出された溶液のまま用いても良いが、さらに必要
により、濾過等の処理をして、濃縮、粉末化したものを
適宜使い分けて用いることが出来る。Each of the above extracts obtained under the above conditions may be used as it is as an extracted solution, but if necessary, it may be subjected to a treatment such as filtration, concentrated and pulverized to be used properly. Can be used.
【0049】本発明の化粧料における抽出物の配合量
は、蒸発乾燥分に換算して0.00001〜50.0重
量%が好ましく、特に0.01〜10.0重量%の範囲
が最適である。The amount of the extract compounded in the cosmetic of the present invention is preferably 0.00001 to 50.0% by weight in terms of evaporated dry matter, and most preferably 0.01 to 10.0% by weight. is there.
【0050】本発明の化粧料は、上記必須成分のほか水
性成分、油性成分、植物抽出物、動物抽出物、粉末、界
面活性剤、油剤、アルコール、pH調整剤、防腐剤、酸
化防止剤、増粘剤、色素、香料等を必要に応じて混合し
て適宜配合することにより調製される。本発明の化粧料
の剤型は特に限定されず、化粧水、乳液、クリーム、パ
ック、パウダー、スプレー、軟膏、分散液、洗浄料等種
々の剤型とすることができる。In addition to the above essential components, the cosmetic of the present invention comprises an aqueous component, an oil component, a plant extract, an animal extract, a powder, a surfactant, an oil agent, an alcohol, a pH adjusting agent, a preservative, an antioxidant, It is prepared by mixing a thickener, a dye, a fragrance and the like as necessary and appropriately blending them. The dosage form of the cosmetic of the present invention is not particularly limited, and various dosage forms such as lotion, emulsion, cream, pack, powder, spray, ointment, dispersion, and cleaning agent can be used.
【0051】[0051]
【実施例】以下、本発明による各種抽出物のコラゲナー
ゼ抑制効果にかかわる試験実施例を示すと共にその素材
を用いた化粧料への応用処方例等について述べるが、こ
こに記載された実施例に限定されないのは言うまでもな
い。[Examples] Hereinafter, test examples relating to the collagenase inhibitory effect of various extracts according to the present invention will be shown, and examples of application prescriptions to cosmetics using the materials will be described. However, the examples are not limited to the examples described here. Needless to say, it is not done.
【0052】(1)試料溶液の調製
試料溶液としては、エピカテキン、エピガロカテキンガ
レート、ルテオリン、フラボン、フラバノン、クエルセ
チン、クエルシトリン、ルチン、ミリセチン、ケンフェ
ロール、ナリンゲニン、ナリンギン、ゲニステイン、ゲ
ニスチン、エスクリン、エスクレチンは市販の試薬を使
用し、ジメチルスルホキシド(DMSO)に溶解させ試
料溶液とした。ブドウ、メマツヨイグサの種子は、乾燥
後細かく粉砕したものを、きのこの白樺茸は子実体を乾
燥後、細かく粉砕したものを、さらにデイジー、エバー
ラスティング、ウワウルシ、コーンフラワー、ミソハ
ギ、グラスポリー、ヒソップ、イブキジャコウソウ、ワ
イルドタイム、エーデルワイス、セントーリ、サボリ
ー、チャービル、ローレル、ホワイトウォーターリリ
ー、ライラック、ポットマリーゴールド、ダミアナ、ス
カビーグラス、レッドクローバー、リリーオブザバリ
ー、ヒエンソウ、タラゴン、クチナシ、ツバキ、レモ
ン、ハゴロモグサ、シロヨモギ、サザンウッド、ウォー
ターミント、ペニーローヤルは全草を乾燥後粉砕したも
のをさらに、リンゴ、ハナカイドウの果皮は乾燥したも
のを粉末にし、50%エタノール水溶液で37℃にて一
週間侵漬抽出した。赤ワイン乾燥粉末は赤ワインを減圧
蒸留し、乾燥粉末を得た。以上のようにして得られた抽
出物を乾燥し、ジメチルスルホキシド(DMSO)を加
えて溶解し、試料溶液とした。(1) Preparation of sample solution As a sample solution, epicatechin, epigallocatechin gallate, luteolin, flavone, flavanone, quercetin, quercitrin, rutin, myricetin, kaempferol, naringenin, naringin, genistein, genistin, esculin As the esculetin, a commercially available reagent was used and dissolved in dimethyl sulfoxide (DMSO) to prepare a sample solution. Grape and evening primrose seeds were dried and finely crushed.Mushroom white birch mushrooms were dried after the fruiting body was finely crushed.Furthermore, daisies, everlasting, ointment, cornflower, miso-hagi, grass polly, hyssop , Ibuki musk, wild thyme, edelweiss, sentry, savory, cherville, laurel, white water lily, lilac, pot marigold, damiana, scabbiegrass, red clover, lily of the barry, japonicum, tarragon, gardenia, camellia, lemon, honeywort, For white wormwood, southern wood, water mint, and penny royal, whole grass is dried and then crushed. Apple and Hana Kaido's pericarp are dried and powdered. It was extracted one week immersed in ℃. The red wine dry powder was obtained by subjecting red wine to vacuum distillation. The extract obtained as described above was dried, and dimethyl sulfoxide (DMSO) was added and dissolved to obtain a sample solution.
【0053】(2)エラスターゼ活性の阻害
基質としてN-succynyl-ala-ala-ala-nitride(sigma社)2
5mgを554μlのDMSOに溶解し、使用時に0.2M Tris-HCl
(PH 8.8)バッファーで100倍希釈して使用した(使用
時濃度1mM)。酵素は豚の膵臓由来のエラスターゼ(65.8
単位/ml:sigma社)を使用した。反応は基質100μl、酵
素20μl(0.1単位)、試料50μl、0.2M Tris-HCl(PH
8.8)ハ゛ッファー130μlを試験管に加え、37℃で30分間静置
後、405nmの吸光度を測定した。エラスターゼ活性阻害
率は下記の式にて算出した。(2) N-succynyl-ala-ala-ala-nitride (sigma) 2 as an inhibitory substrate for elastase activity
Dissolve 5 mg in 554 μl DMSO and use 0.2 M Tris-HCl at the time of use.
It was used after being diluted 100-fold with (PH 8.8) buffer (concentration when used 1 mM). The enzyme is elastase (65.8
Unit / ml: sigma company) was used. The reaction is 100 μl of substrate, 20 μl of enzyme (0.1 unit), 50 μl of sample, 0.2M Tris-HCl (PH
8.8) 130 μl of buffer was added to a test tube, the mixture was allowed to stand at 37 ° C. for 30 minutes, and the absorbance at 405 nm was measured. The elastase activity inhibition rate was calculated by the following formula.
【0054】[0054]
【化1】 [Chemical 1]
【0055】[0055]
【表1】に各種試料のエラスターゼ活性測定の結果を示
す。[Table 1] shows the results of the elastase activity measurement of various samples.
【表1】に示したように、エピカテキン、エピガロカテ
キンガレート、ルテオリン、フラボン、フラバノン、ク
エルセチン、クエルシトリン、ルチン、ミリセチン、ケ
ンフェロール、ナリンゲニン、ナリンギン、ゲニステイ
ン、ゲニスチン、エスクリン、エスクレチン、またブド
ウ、メマツヨイグサの種子、きのこの白樺茸、植物のデ
イジー、エバーラスティング、ウワウルシ、コーンフラ
ワー、ミソハギ、グラスポリー、ヒソップ、イブキジャ
コウソウ、ワイルドタイム、エーデルワイス、セントー
リ、サボリー、チャービル、ローレル、ホワイトウォー
ターリリー、ライラック、ポットマリーゴールド、ダミ
アナ、スカビーグラス、レッドクローバー、リリーオブ
ザバリー、ヒエンソウ、タラゴン、クチナシ、ツバキ、
レモン、ハゴロモグサ、サザンウッド、ウォーターミン
ト、ペニーローヤル、さらにリンゴ、ハナカイドウの果
皮の抽出物、および赤ワイン乾燥粉末はいずれも高いエ
ラスターゼ活性抑制効果を示した。As shown in [Table 1], epicatechin, epigallocatechin gallate, luteolin, flavone, flavanone, quercetin, quercitrin, rutin, myricetin, kaempferol, naringenin, naringin, genistein, genistin, esculin, esculetin, and grape , Evening primrose seed, mushroom birch mushroom, plant daisy, everlasting, oak sumac, cornflower, lythrum, grass polly, hyssop, ibuki musk, wild thyme, edelweiss, sentry, savory, chervil, laurel, white water lily, Lilac, pot marigold, damiana, scabigra, red clover, lily of the barry, hien saw, tarragon, gardenia, camellia,
Lemon, pearl worm, southern wood, water mint, penny royal, apple, peony extract and red wine dry powder all showed high inhibitory effect on elastase activity.
【0056】[0056]
【表1】 [Table 1]
【0057】次に本発明の各種成分を配合した化粧料の
処方例の例を示すが本発明はこれに限定されるものでな
い。Next, examples of formulation of cosmetics containing various components of the present invention will be shown, but the present invention is not limited thereto.
【0058】化粧料の処方例
(1)化粧用クリーム(重量%)
a)ミツロウ…2.0
b)ステアリルアルコール…5.0
c)ステアリン酸…8.0
d)スクワラン…10.0
e)自己乳化型グリセリルモノステアレート…3.0
f)ポリオキシエチレンセチルエーテル(20E.O.)… 1.0
g)ローレル(葉)50%エタノール水溶液抽出物…2.0
h)1,3-ブチレングリコール…5.0
i)水酸化カリウム…0.3
j)防腐剤・酸化防止剤…適量
k)精製水…残部
製法a)〜f)までを加熱溶解し、80℃に保つ。g)〜k)まで
を加熱溶解し、80℃に保ち、a)〜f)に加えて乳化し、40
℃まで撹拌しながら冷却する。Prescription example of cosmetics (1) Cosmetic cream (% by weight) a) Beeswax ... 2.0 b) Stearyl alcohol ... 5.0 c) Stearic acid ... 8.0 d) Squalane ... 10.0 e) Self-emulsifying glyceryl monostearate ... 3.0 f) Polyoxyethylene cetyl ether (20E.O.) ... 1.0 g) Laurel (leaf) 50% ethanol aqueous solution extract ... 2.0 h) 1,3-Butylene glycol ... 5.0 i) Potassium hydroxide ... 0.3 j) Preservative Agents / antioxidants ... Appropriate amount k) Purified water ... Remaining manufacturing methods a) to f) are dissolved by heating and kept at 80 ° C. g) to k) are melted by heating, kept at 80 ° C, added to a) to f) and emulsified.
Cool to 0 ° C with stirring.
【0059】(2)化粧用クリーム(重量%)
a)ミツロウ…2.0
b)ステアリルアルコール…5.0
c)ステアリン酸…8.0
d)スクワラン…10.0
e)自己乳化型グリセリルモノステアレート…3.0
f)ポリオキシエチレンセチルエーテル(20E.O.)…1.0
g)エスクレチン…1.0
h)1,3-ブチレングリコール…5.0
i)水酸化カリウム…0.3
j)防腐剤・酸化防止剤…適量
k)精製水…残部
製法a)〜g)までを加熱溶解し、80℃に保つ。h)〜k)ま
でを加熱溶解し、80℃に保ち、a)〜g)に加えて乳化し、
40℃まで撹拌しながら冷却する。(2) Cosmetic cream (% by weight) a) Beeswax ... 2.0 b) Stearyl alcohol ... 5.0 c) Stearic acid ... 8.0 d) Squalane ... 10.0 e) Self-emulsifying glyceryl monostearate ... 3.0 f) Polyoxy Ethylene cetyl ether (20 E.O.)… 1.0 g) Esculetin… 1.0 h) 1,3-butylene glycol… 5.0 i) Potassium hydroxide… 0.3 j) Preservatives / antioxidants… Appropriate amount k) Purified water… Remainder manufacturing method Dissolve a) to g) by heating and keep at 80 ° C. h) to k) are melted by heating, kept at 80 ° C, added to a) to g) and emulsified,
Cool to 40 ° C with stirring.
【0060】(3)乳液(重量%)
a)ミツロウ…0.5
b)ワセリン…2.0
c)スクワラン…8.0
d)ソルビタンセスキオレエート…0.8
e)ポリオキシエチレンオレイルエーテル(20E.O.)…1.2
f)ブドウ(葉)50%エタノール水溶液抽出物…2.0
g)赤ワイン乾燥粉末…2.0
h)1,3-ブチレングリコール…7.0
i)カルボキシビニルポリマー…0.2
j)水酸化カリウム…0.1
k)精製水…残部
l)防腐剤・酸化防止剤…適量
m)エタノール…7.0
製法a)〜e)までを加熱溶解し、80℃に保つ。f)〜l)まで
を加熱溶解し、80℃に保ち、a)〜e)に加えて乳化し、50
℃まで撹拌しながら冷却する。50℃でm)を添加し、40℃
まで冷却する。(3) Emulsion (% by weight) a) Beeswax ... 0.5 b) Vaseline ... 2.0 c) Squalane ... 8.0 d) Sorbitan sesquioleate ... 0.8 e) Polyoxyethylene oleyl ether (20 E.O.) ... 1.2 f ) Grape (leaf) 50% ethanol aqueous solution extract… 2.0 g) Red wine dry powder… 2.0 h) 1,3-butylene glycol… 7.0 i) Carboxyvinyl polymer… 0.2 j) Potassium hydroxide… 0.1 k) Purified water… The balance l) Preservatives / antioxidants ... Appropriate amount m) Ethanol ... 7.0 Dissolve by heating process a) to e) and keep at 80 ° C. f) to l) are melted by heating, kept at 80 ° C, added to a) to e) and emulsified to 50
Cool to 0 ° C with stirring. M) at 50 ℃, add 40 ℃
Cool down.
【0061】(4)乳液(重量%)
a)ミツロウ…0.5
b)ワセリン…2.0
c)スクワラン…8.0
d)ソルビタンセスキオレエート…0.8
e)ポリオキシエチレンオレイルエーテル(20E.O.)…1.2
f)ワイルドタイム(花)50%エタノール水溶液抽出物…
2.0
g)1,3-ブチレングリコール…7.0
h)カルボキシビニルポリマー…0.2
i)水酸化カリウム…0.1
j)精製水…残部
k)防腐剤・酸化防止剤…適量
l)エタノール…7.0
製法a)〜e)までを加熱溶解し、80℃に保つ。f)〜k)まで
を加熱溶解し、80℃に保ち、a)〜e)に加えて乳化し、50
℃まで撹拌しながら冷却する。50℃でl)を添加し、40℃
まで冷却する。(4) Emulsion (% by weight) a) Beeswax ... 0.5 b) Vaseline ... 2.0 c) Squalane ... 8.0 d) Sorbitan sesquioleate ... 0.8 e) Polyoxyethylene oleyl ether (20 E.O.) ... 1.2 f ) Wild time (flower) 50% ethanol aqueous solution extract ...
2.0 g) 1,3-butylene glycol ... 7.0 h) Carboxyvinyl polymer ... 0.2 i) Potassium hydroxide ... 0.1 j) Purified water ... Balance k) Preservatives / antioxidants ... Appropriate amount l) Ethanol ... 7.0 Manufacturing method a) ~ Heat up to e) and keep at 80 ℃. f) to k) are melted by heating, kept at 80 ° C, added to a) to e) and emulsified.
Cool to 0 ° C with stirring. L) at 50 ℃, add 40 ℃
Cool down.
【0062】(5)化粧水(重量%)
a)ダミアナ(茎)50%エタノール水溶液抽出物…1.0
b)ヒソップ(根)50%1,3-フ゛チレンク゛リコール水溶液抽出物…1.
0
c)グリセリン…5.0
d)ポリオキシエチレンソルビタンモノラウレート(20E.
O.)…1.0
e)エタノール…6.0
f)香料…適量
g)防腐剤・酸化防止剤…適量
h)精製水…残部
製法a)〜h)までを混合し、均一に溶解する。(5) Lotion (% by weight) a) Damiana (stem) 50% ethanol aqueous solution extract ... 1.0 b) Hyssop (root) 50% 1,3-butylene glycol aqueous solution extract ... 1.
0 c) Glycerin ... 5.0 d) Polyoxyethylene sorbitan monolaurate (20E.
O.)… 1.0 e) Ethanol… 6.0 f) Perfume… Appropriate amount g) Preservative / antioxidant… Appropriate amount h) Purified water… The rest of the manufacturing methods a) to h) are mixed and uniformly dissolved.
【0063】(6)化粧水(重量%)
a)ホワイトウォーターリリー(全草)水溶液抽出物…1.0
b)グリセリン…5.0
c)ポリオキシエチレンソルビタンモノラウレート(20E.
O.)…1.0
d)エタノール…6.0
e)香料…適量
f)防腐剤・酸化防止剤…適量
g)精製水…残部
製法a)〜g)までを混合し、均一に溶解する。(6) Lotion (% by weight) a) White water lily (whole grass) aqueous solution extract ... 1.0 b) Glycerin ... 5.0 c) Polyoxyethylene sorbitan monolaurate (20E.
O.) ... 1.0 d) Ethanol ... 6.0 e) Perfume ... Appropriate amount f) Preservative / antioxidant ... Appropriate amount g) Purified water ... Remaining manufacturing method a) to g) are mixed and uniformly dissolved.
【0064】(7)パック剤(重量%)
a)クチナシ(葉)50%エタノール水溶液抽出物…1.0
b)レディースマントル(根)50%エタノール水溶液抽出
物…2.0
c)酢酸ビニル樹脂エマルジョン…15.0
d)ポリビニルアルコール…10.0
e)オリーブ油…3.0
f)グリセリン…5.0
g)酸化チタン…8.0
h)カオリン…7.0
i)エタノール…8.0
j)香料…適量
k)防腐剤・酸化防止剤…適量
l)精製水…残部
製法a)〜l)までを混合し、よく撹拌、分散させ均一にす
る。(7) Packing agent (% by weight) a) Gardenia (leaf) 50% ethanol aqueous solution extract 1.0 b) Ladies mantle (root) 50% ethanol aqueous solution extract 2.0 c) Vinyl acetate resin emulsion 15.0 d ) Polyvinyl alcohol… 10.0 e) Olive oil… 3.0 f) Glycerin… 5.0 g) Titanium oxide… 8.0 h) Kaolin… 7.0 i) Ethanol… 8.0 j) Perfume… Appropriate amount k) Preservatives / antioxidants… Appropriate amount l) Purified water … The rest of the production methods a) to l) are mixed and well stirred and dispersed to homogenize.
【0065】(8)パック剤(重量%)
a)ウォーターミント(全草)50%エタノール水溶液抽出物…1.0
b)酢酸ビニル樹脂エマルジョン…15.0
c)ポリビニルアルコール…10.0
d)オリーブ油…3.0
e)グリセリン…5.0
f)酸化チタン…8.0
g)カオリン…7.0
h)エタノール…8.0
i)香料…適量
j)防腐剤・酸化防止剤…適量
k)精製水…残部
製法a)〜k)までを混合し、よく撹拌、分散させ均一にす
る。(8) Packing agent (% by weight) a) Water mint (whole grass) 50% ethanol aqueous solution extract ... 1.0 b) Vinyl acetate resin emulsion ... 15.0 c) Polyvinyl alcohol ... 10.0 d) Olive oil ... 3.0 e) Glycerin … 5.0 f) Titanium oxide… 8.0 g) Kaolin… 7.0 h) Ethanol… 8.0 i) Perfume… Appropriate amount j) Preservatives / antioxidants… Appropriate amount k) Purified water… The balance a) to k) are mixed, Stir well and disperse well to make uniform.
【0066】[0066]
【効果確認試験】(1)塗布によるヒトでの効果確認試
験
被験者として、20〜50歳の女性15名に1日2回
(朝、夜)連続3ヵ月間、本発明品と比較品のそれぞれ
を使用させ、塗布部位の状態を試験前後で比較し、改善
効果を調べた。本試験には、[Effect confirmation test] (1) Effect confirmation test in human by application As test subjects, 15 women aged 20 to 50 years twice a day (morning, night) for 3 consecutive months, each of the invention product and the comparative product The state of the application site was compared before and after the test, and the improvement effect was investigated. For this test,
【0058】で示した化粧料を用い、比較例にはIn the comparative example, the cosmetics shown in
【0058】に示した化粧料からローレル抽出物を除い
た化粧料を作成し、その塗布による効果について調べ
た。本発明の有効成分を配合した化粧料を毎日塗布しな
がら肌のシワの状態を塗布開始前及び3ヶ月塗布後にお
けるアンケートで集計し、効果の確認を行った。結果はThe cosmetics obtained by removing the laurel extract from the cosmetics shown in (4) were prepared, and the effect of the application was investigated. While applying the cosmetic containing the active ingredient of the present invention every day, the state of wrinkles on the skin was collected by questionnaires before the start of application and after application for 3 months to confirm the effect. Result is
【表2】に示す。It shows in [Table 2].
【0067】<判定基準>
著効:塗布開始前と比較して皮膚のシワが著しく改善し
た。
有効:塗布開始前と比較して皮膚のシワが改善した。
やや有効:塗布開始前と比較して皮膚のシワが少し改善
した。
無効:塗布開始前と比較して変化が無かった。<Judgment Criteria> Remarkable effect: Wrinkles on the skin were remarkably improved as compared with before the start of application. Effective: Wrinkles on the skin were improved compared to before application. Slightly effective: Wrinkles on the skin were slightly improved compared with before application. Ineffective: There was no change compared to before application.
【0068】[0068]
【表2】からも明らかなように、対照品と比較していず
れも高い効果が認められた。As is clear from [Table 2], higher effects were observed in all cases as compared with the control product.
【0069】[0069]
【表2】 [Table 2]
【0070】[0070]
【発明の効果】以上詳述したごとく、本発明の化粧料
は、エラスターゼ活性抑制効果に優れており、皮膚のシ
ワの防止に有効である。As described in detail above, the cosmetic composition of the present invention has an excellent elastase activity suppressing effect and is effective in preventing wrinkles on the skin.
フロントページの続き Fターム(参考) 4C083 AA082 AA111 AA112 AA122 AB032 AB242 AC022 AC072 AC102 AC122 AC182 AC242 AC422 AC442 AC841 AC842 AD092 AD112 AD391 BB01 BB13 BB21 BB41 BB44 BB47 BB48 CC04 CC05 CC07 DD08 DD17 DD22 DD31 EE12 Continued front page F-term (reference) 4C083 AA082 AA111 AA112 AA122 AB032 AB242 AC022 AC072 AC102 AC122 AC182 AC242 AC422 AC442 AC841 AC842 AD092 AD112 AD391 BB01 BB13 BB21 BB41 BB44 BB47 BB48 CC04 CC05 CC07 DD08 DD17 DD22 DD31 EE12
Claims (4)
ボン類および/又はその配糖体、フラボノール類および
/又はその配糖体、フラバノン類および/又はその配糖
体、イソフラボン類および/又はその配糖体、クマリン
類および/又はその配糖体の1種又は2種以上からなるエ
ラスターゼ阻害剤を配合することを特徴とする化粧料。1. Catechins and / or glycosides thereof, flavones and / or glycosides thereof, flavonols and / or glycosides thereof, flavanones and / or glycosides thereof, isoflavones and / or A cosmetic comprising an elastase inhibitor comprising one or more of glycosides, coumarins and / or glycosides thereof.
のこ、ビチス(Vitis)属、オエノセラ(Oenothera)
属、ベリス(Bellis)属、グナファリウム(Gnaphaliu
m)属、アルクトスタフィロス(Arctostaphylos)属、
セントーレ(Centaurea)属、リスラム(Lythrum)属、
ヒソップ(Hyssopus)属、サイムス(Thymus)属、レオ
ントポジウム(Leontopodium)属、セントーリー(Cent
aurium)属、サトレジャ(Satureja)属、アンスリスカ
ス(Anthriscus)属、ロールス(Laurus)属、ニンファ
エア(Nymphaea)属、シリンガ(Syringa)属、カレン
デュラ(Calendula)属、トルネラ(Turnera)属、スカ
ビー(Scurvy)属、トリフォリウム(Trifolium)属、
コンバラリア(Convallaria)属、コンソロダ(Consoli
da)属、アルテミシア(Artemisia)属、ガーデニア(G
ardenia)属、カメリア(Camellia)属、シトラス(Cit
rus)属、アルケミラ(Alchemilla)属、アルテミシア
(Artemisia)属、メンタ(Menth)属、マルス(Malu
s)属に属する植物の抽出物、および赤ワイン乾燥粉末
の1種又は2種以上からなるエラスターゼ阻害剤を配合す
ることを特徴とする化粧料。[Claim 2] Mushrooms belonging to the genus Fuscoporia, genus Vitis, Oenothera
Genus, genus Bellis, Gnaphaliu
m) genus, Arctostaphylos genus,
Genus Centaurea, genus Lythrum,
Hyssopus, Thymus, Leontopodium, Centory
aurium genus, Satureja genus, Anthriscus genus, Laurus genus, Nymphaea genus, Syringa genus, Calendula genus, Tornera genus, Snorvy Genus, Trifolium genus,
The genus Convallaria, Consolida
genus da), genus Artemisia, gardenia (G
ardenia, Camellia, Citrus
genus rus, genus Alchemilla, genus Artemisia, genus Menth, Malus
s) A cosmetic comprising an extract of a plant belonging to the genus and an elastase inhibitor consisting of one or more of red wine dry powder.
キン、エピカテキン、エピガロカテキン、エピガロカテ
キンガレート、フラボン類がルテオリン、フラボン、ア
ピゲニンおよび/又はその配糖体、フラボノール類がク
エルセチン、ミリセチン、ケンフェロールおよび/又は
その配糖体、フラバノン類がナリンゲニン、フラバノ
ン、ヘスペリジンおよび/又はその配糖体、イソフラボ
ン類がゲニステイン、ダイゼインおよび/又はその配糖
体、クマリン類がエスクレチンおよび/又はその配糖体
である請求項1記載の化粧料。3. Catechins and / or glycosides thereof are catechin, epicatechin, epigallocatechin, epigallocatechin gallate, flavones are luteolin, flavones, apigenin and / or glycosides thereof, and flavonols are quercetin, Myricetin, kaempferol and / or its glycosides, flavanones are naringenin, flavanones, hesperidin and / or its glycosides, isoflavones are genistein, daidzein and / or their glycosides, coumarins are esculetins and / or their The cosmetic according to claim 1, which is a glycoside.
のこが白樺茸(Fuscoporia obliqua)、ビチス(Viti
s)属植物がブドウ(Vitis vinifera L.)、オエノセラ
(Oenothera)属植物がメマツヨイグサ(Oenothera bie
nnis L.)、ベリス(Bellis)属に属する植物がデイジ
ー(Bellis perennis)、グナファリウム(Gnaphaliu
m)属に属する植物がエバーラスティング(Gnaphaliumu
liginosum L.)、アルクトスタフィロス(Arctostaphyl
os)属に属する植物がウワウルシ(Arctostaphylos uva
-ursi(L.)SPRENG.)、セントーレ(Centaurea)属に属
する植物がコーンフラワー(Centaurea cyanus L.)、
リスラム(Lythrum)属に属する植物がミソハギ(Lythr
um anceps Makino)、グラスポリー(Lythrum salica
ria L.)、ヒソップ(Hyssopus)属に属する植物がヒソ
ップ(Hyssopus officinalisL.)、サイムス(Thymus)
属に属する植物がイブキジャコウソウ(Thymus quinqu
ecostatus Celak.)、ワイルドタイム(Thymus serpyl
lum L.)、レオントポジウム(Leontopodium)属に属す
る植物がエーデルワイス(Leontopodiumalpinum )、セ
ントーリー(Centaurium)属に属する植物がセントーリ
ー(Centaurium erythraeaRAFN.)、サトレジャ(Satur
eja)属に属する植物がサボリー(Satureja hortensis
L.)、アンスリスカス(Anthriscus)属に属する植物が
チャービル(Anthriscus cerefolium (L.)HOFFM.)、ロ
ールス(Laurus)属に属する植物がローレル(Laurus n
obilis L.)、ニンファエア(Nymphaea)属に属する植
物がホワイトウォーターリリー(Nymphaea albaL.)、
シリンガ(Syringa)属に属する植物がライラック(Syr
inga vulgaris)、カレンデュラ(Calendula)属に属す
る植物がポットマリーゴールド(Calendulaofficinali
s)、トルネラ(Turnera)属に属する植物がダミアナ
(Turnera diffusa WILLD.varaphrodisiaca(WARD.)
URB.)、スカビー(Scurvy)属に属する植物がスカビー
グラス(Scurvy grass)、トリフォリウム(Trifolium)
属に属する植物がレッドクローバー(Trifolium praten
se L.)、コンバラリア(Convallaria)属に属する植物
がリリーオブザバリー(Convallaria majalis L.)、コ
ンソロダ(Consolida)属に属する植物がヒエンソウ(C
onsolida ambigua)、アルテミシア(Artemisia)属に
属する植物がタラゴン(Artemisia dracunculoildes
L.)、ガーデニア(Gardenia)属に属する植物がクチナ
シ(Gardenia jasminoides Ellis f. grandiflora Maki
no)、カメリア属に属する植物がツバキ(Camellia jap
onicaL.)、シトラス(Citrus)属に属する植物がレモ
ン(Citrus limon BURM.)、アルケミラ(Alchemilla)
属に属する植物がハゴロモグサ(Alchemilla vulgarisa
gg.)、アルテミシア(Artemisia)属に属する植物がシ
ロヨモギ(Artemisiastelleriana Besser)、サザンウ
ッド(Artemisia abrotanum L.)、メンタ(Menth)属
に属する植物がウォーターミント(Mentha aquatica
L.)、ペニーローヤル(Mentha pulegium L.)、マルス
(Malus)属に属する植物がリンゴ(Maluspumila Mil
l.)、ハナカイドウ(Malus halliana Koehne)であ
る請求項2記載の化粧料。[Claim 4] Mushrooms belonging to the genus Fuscoporia are white birch mushrooms (Fuscoporia obliqua) and Viti
s) plants are grapes (Vitis vinifera L.) and Oenothera plants are Oenothera bie.
nnis L.), plants belonging to the genus Bellis are daisies (Bellis perennis), and gnafalium (Gnaphaliu).
m) plants belonging to the genus Everlasting (Gnaphaliumu
liginosum L.), Arctostaphyl
The plant belonging to the os genus is Arctostaphylos uva
-ursi (L.) S PRENG. ), a plant belonging to the genus Centaurea is cornflower (Centaurea cyanus L.),
A plant belonging to the genus Lythrum is Lythr.
um anceps Makino), grass polly (Lythrum salica)
ria L.), plants belonging to the genus Hyssopus are Hyssopus officinalis L., Thymus
The plant belonging to the genus is Thymus quinqu
ecostatus Celak.), Wild Time (Thymus serpyl
lum L.), plants belonging to the genus Leontopodium are Edelweiss (Leontopodiumalpinum), plants belonging to the genus Centaurium (Centaurium erythraeaR AFN. ), and Saturja (Satur) .
A plant belonging to the genus eja) is a savory (Satureja hortensis
L.), a plant belonging to the genus Anthriscus (Anthriscus cerefolium (L.) H OFFM .), And a plant belonging to the genus Rolls (Laurus) are laurel (Laurus n
obilis L.), a plant belonging to the genus Nymphaea (Nymphaea) is white water lily (Nymphaea albaL.),
Plants belonging to the genus Syringa are lilacs (Syringa)
inga vulgaris) and plants belonging to the genus Calendula (Calendula) are pot marigolds (Calendula officinali).
s), plants belonging to the genus Turnera (Turnera diffusa W ILLD .varaphrodisiaca (W ARD .)
U RB .), Plants belonging to the genus Scurvy are Scurvy grass, Trifolium
Plants belonging to the genus Red clover (Trifolium praten
se L.), plants belonging to the genus Convallaria are Lily of the Barry (Convallaria majalis L.), plants belonging to the genus Consolida
onsolida ambigua), the plant belonging to the genus Artemisia (Artemisia) is taragon (Artemisia dracunculoildes)
L.), a plant belonging to the genus Gardenia is gardenia jasminoides Ellis f. Grandiflora Maki
no), Camellia jap is a plant belonging to the genus Camellia.
onicaL.), plants belonging to the genus Citrus are lemons (Citrus limon B URM .), Alchemilla.
The plants belonging to the genus are Alchemilla vulgarisa
gg.), plants belonging to the genus Artemisia are Artemisia stelleriana Besser, southern wood (Artemisia abrotanum L.), and plants belonging to the genus Menth are water mint (Mentha aquatica).
L.), Penny Royal (Mentha pulegium L.), Malus (Malus) plants belonging to the genus Apple (Maluspumila Mil
l.), and Hana Kaido (Malus halliana Koehne).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001189708A JP4901025B2 (en) | 2001-06-22 | 2001-06-22 | Elastase inhibitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001189708A JP4901025B2 (en) | 2001-06-22 | 2001-06-22 | Elastase inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003002820A true JP2003002820A (en) | 2003-01-08 |
| JP4901025B2 JP4901025B2 (en) | 2012-03-21 |
Family
ID=19028593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001189708A Expired - Lifetime JP4901025B2 (en) | 2001-06-22 | 2001-06-22 | Elastase inhibitor |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4901025B2 (en) |
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