JP2003073694A - Chemical solution for wet wipes and wet wipes using the same - Google Patents

Abstract

(57) [Summary] [Problem] To provide a chemical solution and wet wipes that have high antibacterial and antibacterial effects and low skin irritation even when the preservative is used in a reduced proportion compared to the prior art. SOLUTION: A chemical solution containing ε-polylysine and / or a salt thereof and a preservative is impregnated into a wet wipes substrate.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid medicine for wet wipes and wet wipes using the same.

[0002]

2. Description of the Related Art Wet wipes are water-retaining woven fabrics, nonwoven fabrics, papers, and other base materials impregnated with a chemical solution containing a cleaning agent, a moisturizing agent, a disinfectant, a fragrance, etc. It is used in restaurants, offices, factories, etc. to wipe the hands and fingers and to clean furniture and equipment.

Wet wipes are added with antibacterial agents and antiseptics as antiseptics for the purpose of preventing spoilage by microorganisms such as bacteria and mold. In particular, in medical institutions and the like, wet wipes containing an antibacterial agent or a bactericide are used for the purpose of sterilizing and erasing pathogenic microorganisms.

[0004]

The antibacterial agent, antiseptic agent, and bactericidal agent added to wet wipes include benzoic acid, benzoic salts, parahydroxybenzoic acid esters,
Sorbic acid, sorbates, benzalkonium chloride,
Benzethonium chloride and cetylpyridinium chloride are used.

However, these antibacterial agents, antiseptics,
Since many antiseptics such as bactericides have high oral toxicity and skin irritation, it is desirable that the amount used is as small as possible. On the other hand, there is a problem that the antiseptic effect (antibacterial / bactericidal effect) of wet wipes is reduced when the amount of the antiseptic used is reduced.

As a wet wipe excellent in safety,
Wet wipes using ε-polylysine, which is a naturally occurring food preservative, and / or its salt as an antibacterial agent have been proposed. However, ε-polylysine and / or a salt thereof has an excellent growth inhibitory effect on bacteria, but is inferior in the growth inhibitory effect on fungi such as mold and yeast. Therefore, a large amount of ε-polylysine and / or the salt thereof is used. Since it is necessary to add a salt, there is a problem that the cost becomes high in an application requiring an antifungal effect.

[0007]

DISCLOSURE OF THE INVENTION The inventors of the present invention have made extensive studies in view of the above-mentioned problems of the prior art. As a result, a chemical solution containing ε-polylysine and / or a salt thereof and an antiseptic agent, when used in a wafer and a wipe, has a significantly smaller amount of the antiseptic agent, ε-polylysine and / or that in the prior art. It was found that not only the antiseptic effect (antibacterial / antifungal) is excellent even in the addition ratio of the salt, but also the skin is not rough and the skin is not irritating, and the present invention was completed based on this finding.

The present invention has the following configurations (1) to (13).

(1) A chemical solution for wet wipes containing ε-polylysine and / or a salt thereof and a preservative.

(2) The content ratio of ε-polylysine and / or its salt is in the range of 0.00001 to 5% by weight with respect to the drug solution, and the content ratio of the preservative is 0.001 to 0.001 with respect to the drug solution. The chemical solution for wet wipes according to the above item 1, which is in a range of 5% by weight.

(3) The antiseptic agent is sorbic acid, sorbic acid metal salt, dehydroacetic acid, dehydroacetic acid metal salt, propionic acid, propionic acid metal salt, benzoic acid, benzoic acid metal salt, methyl parahydroxybenzoate, parahydroxy. The wet wipe according to claim 1 or 2, which is one or more selected from ethyl benzoate, propyl parahydroxybenzoate, isopropyl parahydroxybenzoate, isobutyl parahydroxybenzoate, butyl parahydroxybenzoate, and phenoxyethanol. Liquid chemicals

(4) The invention further comprising an electrolyte.
The chemical solution for wet wipes according to any one of 1 to 3.

(5) The fourth aspect wherein the content ratio of the electrolyte is in the range of 0.000001 to 30% by weight with respect to the chemical solution.
The chemical liquid for wet wipes according to the item.

(6) The chemical solution for wet wipes according to the above item 4, wherein the electrolyte is one or more selected from acids and salts.

(7) The acid is one selected from hydrochloric acid, phosphoric acid, acetic acid, lactic acid, succinic acid, tartaric acid, citric acid, malic acid, fumaric acid, adipic acid, gluconic acid, propionic acid, and maleic acid. The chemical liquid for wet wipes according to the above item 6, which is the above.

(8) The salt is a hydrochloric acid metal salt, a phosphoric acid metal salt, an acetic acid metal salt, a lactic acid metal salt, a succinic acid metal salt, a tartaric acid metal salt, a citric acid metal salt, a malic acid metal salt, a fumaric acid metal salt, The chemical liquid for wet wipes according to the above item 6, which is at least one selected from a metal adipate, a metal gluconate, a metal propionate, and a metal maleate.

(9) The chemical solution for wet wipes according to the above item 4, wherein the electrolyte is a pH buffering agent.

(10) The pH buffer is a pH buffer solution containing one or more acids selected from citrate, citric acid, malic acid, lactic acid, acetic acid, succinic acid, and phosphoric acid, and salts thereof. The chemical liquid for wet wipes according to item 9.

(11) A wet wipe comprising the chemical liquid for wet wipes according to any one of items 1 to 10 and a wet wipes base material.

(12) The wet wipes according to the above item 11, wherein the base material for the wet wipes is a woven fabric, a non-woven fabric or a paper containing a cellulosic fiber.

(13) The wet wipes according to the above item 11, wherein the weight ratio of the wet wipes chemical liquid and the wet wipes base material (chemical liquid / wet wipes base material) is in the range of 0.5 to 5. .

[0022]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail below. The drug solution of the present invention is not particularly limited as long as it is a liquid containing ε-polylysine and / or a salt thereof and an antiseptic agent, but the effects on the skin such as rough skin and skin irritation, and further cost. From the viewpoint of ease of handling and handling, an aqueous solution containing ε-polylysine and / or its salt and a preservative is preferable.

The content ratio of polylysine and / or its salt in the liquid medicine is preferably 0.00001 to 5% by weight, more preferably 0.0005 to 0.1% by weight. Further, the content ratio of the antiseptic agent to the chemical solution,
Preferably 0.001 to 5% by weight, more preferably 0.1.
It is in the range of 001 to 1% by weight.

The antiseptic effect of the chemical solution of the present invention can be arbitrarily controlled by adjusting the content ratio of polylysine and / or its salt and the preservative in the chemical solution. That is, if the content ratio of polylysine and / or its salt and the preservative is reduced, the antiseptic effect can be imparted to the chemical solution, and if the content ratio is increased,
In addition to the antiseptic effect, the chemical solution can also have a bactericidal effect.

The ε-polylysine used in the present invention can be used in the chemical solution of the present invention regardless of the method obtained, but specifically, Patent No. 1245 is used.
The composition of Streptomyces alplus subspecies lysinopolymeras described in No. 361 has a composition of glucose 5% by weight, yeast extract 0.5% by weight, ammonium sulfate 1% by weight, dipotassium hydrogenphosphate 0.08% by weight. , Potassium dihydrogen phosphate 0.136% by weight, magnesium sulfate heptahydrate 0.05% by weight, zinc sulfate heptahydrate 0.004% by weight, and iron sulfate heptahydrate 0.03%
An example is ε-polylysine obtained by culturing in a medium having a weight percentage of 6.8 and having a pH adjusted to 6.8, and separating and collecting ε-polylysine from the obtained culture.

The ε-polylysine used in the present invention may be a free ε-polylysine, and may be an ε-polylysine formed by ε-polylysine with an inorganic acid such as hydrochloric acid, sulfuric acid and phosphoric acid. Inorganic acid salts and organic acid salts of ε-polylysine formed by ε-polylysine and organic acids such as acetic acid, propionic acid, fumaric acid, malic acid, citric acid, maleic acid, adipic acid, gluconic acid, and lactic acid. Or

Saturated fatty acid salts of ε-polylysine formed by medium- and long-chain saturated fatty acids such as caproic acid, lauric acid, and stearic acid, and ε-polylysine, oleic acid, linoleic acid, and arachidonic acid. It may be an unsaturated fatty acid salt of ε-polylysine formed by medium-chain and long-chain unsaturated fatty acids and ε-polylysine.
After this, salts of the above-mentioned various acids with ε-polylysine,
And free ε-polylysine are collectively referred to as “EPL”.

The antiseptic agent used in the chemical solution of the present invention is not particularly limited, but sorbic acid, sorbic acid metal salt, dehydroacetic acid, dehydroacetic acid metal salt, propionic acid, propionic acid metal salt, benzoic acid, benzoic acid metal salt, One or more selected from methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, isopropyl parahydroxybenzoate, isobutyl parahydroxybenzoate, butyl parahydroxybenzoate, and phenoxyethanol can be preferably used. .

An electrolyte may be further added to the chemical solution of the present invention. The addition of an electrolyte causes ε-, which is a cationic substance
Polylysine and / or a salt thereof and an anionic substance, for example, a fatty acid metal salt, a higher alkyl sulfate ester salt, an alkyl ether sulfate ester salt, an alkylbenzene sulfonate, a paraffin sulfonate, a higher alcohol phosphate ester added to a chemical solution Prevents the adsorption of anionic surfactants such as salts, mucopolysaccharides such as hyaluronic acid and chondroitin sulfate, and cellulosic fibers that are wet wipes base materials, and the formation of salts, and has an antiseptic effect. Can be prevented.

The content ratio of the electrolyte in the chemical solution containing the electrolyte of the present invention is not particularly limited, but is preferably 0.000001 to 30% by weight, more preferably 0.0001 to 10% by weight. It is preferable.

The electrolyte used in the chemical solution of the present invention is not particularly limited, but examples of the electrolyte preferably usable in the present invention include acids and salts.

Acids include hydrochloric acid, phosphoric acid, acetic acid, lactic acid,
Examples thereof include succinic acid, tartaric acid, citric acid, malic acid, fumaric acid, adipic acid, gluconic acid, propionic acid, and maleic acid.

As the salt, a metal salt of hydrochloric acid, a metal salt of phosphoric acid,
Metal acetate, lactic acid metal, succinic acid metal salt, tartaric acid metal salt, citric acid metal salt, malic acid metal salt, fumaric acid metal salt, adipic acid metal salt, gluconic acid metal salt, propionic acid metal salt, and maleic acid. Examples thereof include metal salts.

Further, as the electrolyte used in the chemical solution of the present invention, a pH buffering agent can be mentioned. The pH buffering agent is not particularly limited as long as it has a pH buffering ability, but in the chemical solution of the present invention, a weakly acidic substance-weakly basic substance, a weakly acidic substance-strongly basic substance, a strongly acidic substance-weakly base. It is preferred to use a pH buffer composed of the substance. Specifically, phosphate-phosphate metal salt buffer, acetic acid-acetate metal salt buffer, lactic acid-lactic acid metal salt buffer, succinic acid-succinic acid metal salt buffer, tartaric acid-tartaric acid metal salt buffer, Examples thereof include citric acid-citrate metal salt buffer solutions and malic acid-malate metal salt buffer solutions.

The chemical solution of the present invention may contain alcohol as long as the effects of the present invention are not impaired. Addition of alcohol can be expected to reinforce the fat-soluble effect and the cleaning effect. Examples of the alcohol include lower alcohols such as ethyl alcohol and isopropyl alcohol, and higher alcohols such as isostearyl alcohol, cetyl alcohol and behenyl alcohol.

Further, the chemical liquid of the present invention contains a bamboo extract, allyl mustard oil, protamine, tea extract, grapefruit seed extract, lysozyme, chitosan, as long as the effects and safety of the present invention are not impaired. , And naturally-occurring antibacterial substances such as hinokitiol, EPL antibacterial effect-enhancing substances such as glycerin fatty acid ester and sucrose fatty acid ester, and nonionic surfactants such as alkyl glycosides, amino acids such as glycine and alanine,

Glycerin, propylene glycol, polyethylene glycol, squalane, hyaluronic acid, royal jelly, botanical extract, and other moisturizers commonly used in wet wipe chemicals, solubilizing agents such as dextrin, Additives such as thickeners, pigments, antioxidants, detergents, anti-inflammatory agents, cooling agents, and fragrances may be added.

Next, the wet wipes which is another invention of the present invention will be described in detail. The wet wipes of the present invention are composed of the chemical liquid for wet wipes of the present invention and the base material for wet wipes. The wet wipes base material used in the wet wipes of the present invention is not particularly limited, but specifically, pulp, cotton, natural cellulose fibers such as hemp, silk, natural protein fibers such as wool,
Regenerated cellulose fibers such as cupra, bemberg, rayon and acetate, acrylic fibers, polyparaphenylene fibers, vinylon fibers, polyurethane fibers, polyvinyl chloride fibers, polyamide fibers such as nylon 6, nylon 66 and nylon 610,

It is formed by using one or more kinds of fibers selected from polyester fibers such as polyethylene terephthalate and polybutylene terephthalate, polyolefin fibers such as polyethylene and polypropylene, and synthetic fibers such as poly-L-lactic acid fiber. Woven cloth, non-woven cloth,
You can mention paper.

Among them, woven fabrics containing cellulosic fibers such as natural cellulose fibers and regenerated cellulose fibers,
Nonwoven fabric and paper have high hydrophilicity and water retention,
It can be preferably used as the wet wipes base material of the present invention.

The method for producing the wet wipes base material used in the present invention is not particularly limited, but if the above-mentioned fiber is a woven fabric, it may be produced by a known method such as a single woven fabric, a double woven fabric or a multiple woven fabric. Good. Manufactured by known methods such as dry method, wet method, water jet method, spunbond method, airlaid method, needle punch method, felt method, etc. for non-woven fabric, and known method such as strain net paper making method for paper. Those described above can be preferably used in the present invention.

The wet wipes of the present invention are obtained by dipping the above-mentioned wet wipes base material with the chemical solution of the present invention by a dipping method, a spreading method,
It can be produced by impregnation by a known method such as a spray method. The amount of the chemical liquid when impregnating the wet wipes is not particularly limited, but in the present invention, the weight ratio of the chemical liquid and the wet wipes base material (chemical liquid of the present invention / wet wipes base material). ) Is preferably in the range of 0.5 to 5, particularly preferably in the range of 1 to 3. When the weight ratio of the chemical liquid to the wet wipes base material is within the range, it is easy to obtain a sufficient wiping effect and a good feeling of use.

The wet wipes of the present invention are bacteria,
It exhibits high antibacterial and bactericidal effects against a wide range of microorganisms such as yeast and mold. Further, by controlling the amount of EPL, preservative, and electrolyte added in the chemical solution, not only the prevention of microbial spoilage during storage of wet wipes, but also the sterilizing and disinfecting effects of wet wipes can be imparted. it can.

[0044]

EXAMPLES The present invention will be described in detail below with reference to examples. In addition, "%" in the following examples is "% by weight" unless otherwise specified. Table 1 shows the samples (ε-polylysine, synthetic preservatives, electrolytes, media) used in this example, and the abbreviations of the samples used in the examples.

[0045]

[Table 1]

1. Wet wipes base material A commercially available spunlace nonwoven fabric (manufactured by Sansho Paper Co., Ltd., Sunmore KP9340) was used as the wet wipes base material.

2. Preparation of wet wipes 1 (Example 1)
.About.27, Comparative Examples 1 to 6) According to the ratios shown in Table 1, a chemical solution containing EPL, an antiseptic, and an electrolyte was prepared. 20 g of the wet wipes base material was uniformly impregnated with 40 g of the chemical solution to prepare wet wipes of Examples 1 to 27 and Comparative Examples 1 to 6.

[0048]

[Table 2]

[0049]

[Table 3]

[0050]

[Table 4]

[0051]

[Table 5]

[0052]

[Table 6]

[0053]

[Table 7]

[0054]

[Table 8]

[0055]

[Table 9]

[0056]

[Table 10]

3. Wet Wipes Antiseptic Effect Test 1 For each of the wet wipes of Examples 1 to 27 and Comparative Examples 1 to 6, the antiseptic effect against bacteria was measured by the method described below. 3-1. Preparation of test bacterial solution 1 Escherichia coli ( Escherichia coli , Escherichia coli ,
IFO12734) has a viable cell count of 10 ⁵ cells / mL
The test bacterial solution 1 was obtained by adjusting the concentration to a level.

3-2. Preparation of Test Bacteria Solution 2 Using sterile pipette, sterilize Staphylococcus aureus ( Staphylococcu) in sterilized 1/500 concentration normal broth medium.
aureus , IFO12732), so that the viable cell count in the medium is adjusted to a concentration of 10 ⁵ cells / mL,
A test bacterial solution 2 was obtained.

3-3. Antiseptic Effect Test 1 0.2 g of each wet wipe of Examples 1 to 27 and Comparative Examples 1 to 6 was cut out and placed in a sterile vial bottle with a screw lid having a volume of 30 mL. 1
mL was inoculated uniformly and cultured for 18 hours at a temperature of 36 ± 1 ° C. After the completion of the culture, 20 mL of sterile physiological saline (pH 7.4) was added to the sterile vial and shaken well, and the viable cell count in 1 mL of the obtained test bacterial extract was measured by the standard agar medium method. The test results are shown in Table 11.

3-4. Antiseptic effect test 2 An antiseptic effect test was conducted according to the method described in "3-3. Antiseptic effect test 1" except that the test bacterial solution was changed to the test bacterial solution 2. The test results are shown in Table 11.

[0061]

[Table 11] E. coli; Escherichia coli ,
IFO13500) S. aureus; Staphylococcus
s aureus , IFO12732)

As is clear from Table 11, Examples 1-2
The wet wipe of No. 7 has an excellent antiseptic effect against Escherichia coli and Staphylococcus aureus as compared with the wet wipes of Comparative Examples 1 to 6.

4. Wet Wipes Antiseptic Effect Test 3 For each of the wet wipes of Examples 1 to 27 and Comparative Examples 1 to 6, the antiseptic effect against mold was measured by the method described below.

4-1. Preparation of test bacterial solution 3 Using a sterilized pipette, add black mold ( Aspergill) to a sterilized 1 / 100-concentration potato dextrose broth medium.
us niger , IFO 4067) so that the number of spores in purified water will be at a concentration of 10 ⁵ cells / mL,
A test bacterial solution 3 was obtained.

4-2. Antiseptic Effect Test 3 0.2 g of each wet wipe of Examples 1 to 27 and Comparative Examples 1 to 6 was cut out and put in a sterile vial bottle with a screw lid having a volume of 30 mL. 1
The cells were uniformly inoculated with mL and cultured at a temperature of 30 ± 1 ° C. for 72 hours. After the completion of the culture, 20 mL of sterile physiological saline (pH 7.4) was added to the sterile vial and shaken well, and the viable cell count in 1 mL of the obtained test bacterial extract was measured by the standard agar medium method. The test results are shown in Table 12.

[0066]

[Table 12] Test bacterium; Aspergillus niger
(IFO4091))

As is clear from Table 12, Examples 1-2
The wet wipe of No. 7 has an excellent antiseptic effect against black mold as compared with the wet wipes of Comparative Examples 1 to 6.

5. Skin Roughness Test Each of the wet wipes of Examples 1 to 27 and Comparative Examples 1 to 6 was cut into a size of 30 mm × 30 mm, brought into contact with the inside of the lower arm of each panelist, and after 5 minutes, the wet wipes were removed. After that, the contact part was air dried. This operation was repeated 3 times per day for 2 weeks, and the skin condition was self-reported. There were a total of 20 panelists, 10 male and 10 female, and multiple answers were possible regarding skin discomfort and defects.
The test results are shown in Table 13.

[0069]

[Table 13]

As is clear from Table 13, the wet wipes of Examples 1 to 27 of the present invention are less likely to cause rough skin than the wet wipes of Comparative Examples 1 to 6.

[0071]

INDUSTRIAL APPLICABILITY The chemical solution for wet wipes and wet wipes of the present invention have a high antiseptic effect (antibacterial / bactericidal effect) even when the proportion of the antiseptic used is reduced as compared with the prior art, and Because it is less irritating to the skin,
It can be widely and suitably used in offices, factories, medical institutions, etc. for wiping fingers and bodies and for cleaning furniture and equipment. Furthermore, the chemical solution and wet wipes of the present invention can be manufactured at low cost by reducing the addition ratio of expensive ε-polylysine and / or its salt.

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Claims (13)

[Claims] 1. A chemical solution for wet wipes, which contains ε-polylysine and / or a salt thereof and a preservative. 2. The content ratio of ε-polylysine and / or its salt is in the range of 0.00001 to 5% by weight with respect to the drug solution, and the content ratio of the preservative is 0.0 with respect to the drug solution.
The chemical liquid for wet wipes according to claim 1, which is in the range of 01 to 5% by weight. 3. An antiseptic agent is sorbic acid, sorbic acid metal salt, dehydroacetic acid, dehydroacetic acid metal salt, propionic acid, propionic acid metal salt, benzoic acid, benzoic acid metal salt,
4. One or more selected from methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, isopropyl parahydroxybenzoate, isobutyl parahydroxybenzoate, butyl parahydroxybenzoate, and phenoxyethanol. Or the chemical liquid for wet wipes according to 2. 4. The chemical solution for wet wipes according to claim 1, further containing an electrolyte. 5. The content ratio of the electrolyte is 0.
The chemical solution for wet wipes according to claim 4, which is in the range of 000001 to 30% by weight. 6. The chemical solution for wet wipes according to claim 4, wherein the electrolyte is one or more selected from acids and salts. 7. The acid is one or more selected from hydrochloric acid, phosphoric acid, acetic acid, lactic acid, succinic acid, tartaric acid, citric acid, malic acid, fumaric acid, adipic acid, gluconic acid, propionic acid, and maleic acid. The chemical liquid for wet wipes according to claim 6. 8. The salt is a hydrochloric acid metal salt, a phosphoric acid metal salt, an acetic acid metal salt, a lactic acid metal salt, a succinic acid metal salt, a tartaric acid metal salt,
The wet according to claim 6, which is one or more selected from metal citrate, metal malate, metal fumarate, metal adipate, metal gluconate, metal propionate, and metal maleate. Chemicals for wipes. 9. The chemical solution for wet wipes according to claim 4, wherein the electrolyte is a pH buffering agent. 10. The pH buffer is citrate, citric acid,
The chemical solution for wet wipes according to claim 9, which is a pH buffer solution comprising at least one acid selected from malic acid, lactic acid, acetic acid, succinic acid, and phosphoric acid, and a salt thereof. 11. A wet wipe comprising the chemical liquid for wet wipes according to claim 1 and a wet wipes base material. 12. The wet wipes according to claim 11, wherein the wet wipes base material is a woven fabric, a non-woven fabric, or paper containing cellulosic fibers. 13. A weight ratio of a chemical liquid for wet wipes and a wet wipes base material (chemical liquid / wet wipes base material).
Is in the range of 0.5 to 5, wherein the wet wipes of claim 11.