JP2002275060A - Melanogenesis promoting agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new and safe cosmetic composition. SOLUTION: The melanogenesis promoting agent or cosmetic composition contains at least one compound selected from salicylic acid, its derivatives and their salts and/or at least one compound selected from salicyl alcohol or its derivatives as active components. The melanogenesis promoting agent or cosmetic composition containing at least one compound selected from salicylic acid, its derivatives and their salts and/or at least one compound selected from salicyl alcohol or its derivatives as active components has excellent melanogenesis promoting action, increases the melanine contents of the skin and hair to protect the skin from various disorders caused by ultraviolet rays, or the like, and gives brown skin and black hair having excellent appearance. The cosmetic composition can sufficiently develop the effect of active components to improve various skin and hair states simultaneously with the promotion of melanogenesis and is more preferable from the viewpoint of functionality.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an active ingredient comprising at least one compound selected from salicylic acid or a derivative thereof or a salt thereof, and / or at least one compound selected from salicylic alcohol or a derivative thereof. The present invention relates to a melanin production promoter contained as a cosmetic or an application to a cosmetic composition.

[0002]

2. Description of the Related Art One of the factors that determine the color of human skin and hair
First, the amount of melanin in the epidermis and hair is closely related. This melanin pigment is produced by melanosomes, which are organelles in pigment cells (melanocytes) present in the basal layer of the epidermis, the root of the hair, and the outer root sheath. Than depositing
The color of the skin and hair is formed. This melanin pigment not only has a function of forming the color of the skin and hair, but also has a function of protecting skin tissues from ultraviolet rays, which is an important role in the skin.

[0003] However, Caucasians with a low amount of melanin in the skin and persons with imperfect pigment cells are susceptible to the adverse effects of ultraviolet light, and have small pigment spots (stains), vitiligo vulgaris, and depigmentation due to disorders of hypopigmentation. It is easy to cause skin diseases such as nevus and irregular pigmentation, and, in severe cases, skin cancer such as melanoma. In addition, the amount of melanin in the hair also tends to decrease with aging. It is in a state where improvement is desired.

[0004] With respect to the protection of the skin against ultraviolet rays, there has been a method of eliminating ultraviolet rays by using an ultraviolet ray blocking agent or an ultraviolet absorber, and conversely, irradiating the skin with appropriate ultraviolet rays. A method is known in which the production of melanin pigment is promoted and the melanin pigment is deposited on the skin, so that the ultraviolet protective action inherent to the skin is exhibited, and the external effect such as brown skin color is exhibited. For hair, cosmetic improvement has been achieved by dyeing fading hair into black using a hair dye or the like.

[0005] However, the method of irradiating the skin with ultraviolet rays appropriately is to apply ultraviolet rays, particularly UV-A, to the dermis layer of collagen or elastin before the melanin pigment induced by the ultraviolet irradiation is deposited. Very severe skin disorders such as destruction of the fibers of the skin and reduction of skin elasticity and generation of active oxygen and lipid peroxide which are deeply involved in skin aging occur. In addition, since the hair is temporarily dyed with a hair dye, there are problems that the maintenance of black color is not permanent, and that a uniform color cannot be obtained depending on the treatment method.

[0006]

In view of such circumstances, the present inventors have proposed that the generation and deposition of melanin pigment in skin or hair induces and promotes the formation of skin without causing skin disorders. A method for exhibiting an ultraviolet protective effect and a method for exhibiting an external effect such as uniform color of skin and prevention or improvement of fading of hair were studied. As a result, at least one or more compounds selected from salicylic acid or a derivative thereof or a salt thereof, and / or at least one or more compounds selected from salicyl alcohol or a derivative thereof cause melanin production in pigment cells (melanocytes). It has a finding that it has an accelerating effect and increases the amount of melanin in skin and hair.

[0007]

That is, the present invention provides at least one compound selected from salicylic acid or a derivative thereof or a salt thereof, and / or at least one compound selected from salicylic alcohol or a derivative thereof. And a cosmetic composition containing a melanin production accelerator as an active ingredient.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION Salicylic acid or a derivative thereof used in the present invention is a compound having a structure represented by the general formula I. Salicyl alcohol or a derivative thereof used in the present invention is a compound having a structure represented by the general formula II.

[0009]

[Formula 3] [R ₁ in the general formula is a compound having a carboxyl group (—COOH) or a compound having an ester group with a compound having a hydroxyl group (—OH), or a compound having an amino group (—NH ₂ ) and an amide It is a carboxyl group forming a bond. R ₂ is a hydroxyl group, or a hydroxyl group forming an ester bond with a compound having a carboxyl group,
Or a hydroxyl group forming an ether bond with a compound having a hydroxyl group. ]

[0010]

## STR4 ## Formula II [R ₃ in the general formula is a compound having an ester bond with a compound having a hydroxymethyl group (—CH ₂ OH) or a carboxyl group, or an ether bond with a compound having a hydroxyl group. Is a hydroxymethyl group. R ₄ is a hydroxyl group (—OH), a hydroxyl group forming an ester bond with a compound having a carboxyl group, or a hydroxyl group forming an ether bond with a compound having a hydroxyl group. ]

As the compound having an amino group represented by the general formula I, any compound having at least one amino group is applicable, and examples thereof include guanine, adenine, cytosine, thymine, uracil, isoguanine, and the like.
Nucleic acids such as glycylglycine, glycylproline, citrulline, glutathione, cystation, and cysteic acid;
Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine ,
N-acetylglutamic acid, N-acetylmethionine, N-acetylornithine, N-acetylglycine, N-acetylserine, adenosylhomocysteine, adenosylmethionine, alanylglycine, arginosuccinic acid, alloisoleucine, allothreonine, isovaline, γ -Glutamylcysteine, norleucine, hydroxytryptophan, hydroxyphenylglycine, hydroxylysine,
Amino acids such as phenylglycine, phenylglycinecarboxylic acid, homoserine, methylcysteine, methylhistidine, lanthionine, aminoacetic acid, methylol urea,
Meprobamate, methylhydroxylamine, methylguanidine, lactamide, aminoethanol, ethylamine, aminovaleric acid, isoaminovaleric acid, aminobutyric acid,
Aminolevulinic acid, ethylhydrazine, ethylhydroxylamine, ethylhexylamine, octylamine,
Carbamic acid, isopentylamine, glycolamide, chloroacetamide, butylamide, butylamine, propionamide, propylamine, urea, bromovalerylurea, bromoisovalerylurea, hexanamide, hexylamine, heptamide, formamide oxime, methacrylamide, methylthio Monovalent amides such as urea, methylnitrourea, methylurea, adipamide, guanidine, pentanediamine, glycinamide,
Guanidinobutyramide, phthalamide, benzenetriamine, polyamides such as malamide, anisidine, aniline, aminoacetanilide, aminoacetophenone,
Aminoazotoluene, aminoazonaphthalene, aminoazobenzene, aminoanthraquinone, aminoquinoline,
Aminocresol, aminodichlorophenol, aminostyrene, aminotoluenesulfonic acid, aminonaphthol, aminonitrobenzoic acid, aminonitrophenol,
Aminopicoline, aminophenol, aminobenzoic acid,
Ethyl aminobenzoate, methyl aminobenzoate, aminocinnamic acid, aminophthalimide, aminofluorene, aminobenzyl alcohol, aminobenzenesulfonic acid,
Aminobenzenethiol, aminobenzonitrile, aminoresosinol, amphetamine, ethylaniline, ethylphenylhydrazine, orthocaine, carbacrylamine, xylidine, xylylenediamine, chloroaniline, phenacylamine, phenylacetamide, phenylsemicarbamide, phenylhydrazine , Phenetidine, phenethylamine, butylaniline, flavaniline, fluoroorangeamine, fluoroaniline, procaine, bromoaniline, bromophenylhydrazine, benzidine, benzylaniline, benzylamine, benzylthiourea, benzylurea, benzylhydrazine, benzylhydroxylamine, benzamidine, Benzamide, benzamide oxime, benzaldehyde hydrazone, benzene sulfone Amid, benzoylthiourea, benzoylurea, benzohydrazide, pentachloroaniline, pentamethylaniline, mescaline, methylphenylhydrazine, aromatic amides such as methylphenylenediamine, methylbenzylamine, iodoaniline, and others, acetazolamide, glucosamine, aceto Racenamide, uramil, camfilamine, furfurylamine,
Methylcytosine, methoxytryptamine, melamine, luminol, leucoaniline, leucopterin, guanidine, aminoguanidine and the like. Particularly, it is preferable to use 2-hydroxybenzoylaminoacetic acid in which R ₁ in the general formula I forms an amide bond with aminoacetic acid and R ₂ is a hydroxyl group.

As the compounds having a carboxyl group represented by the general formulas I and II, all compounds having at least one carboxyl group are applicable. For example, acetoxypropionic acid, isovaleric acid, aminovaleric acid , Ethoxyacetic acid, ethoxypropionic acid, isoaminovaleric acid, epoxy oleic acid, elaidic acid, aminobutyric acid, erucic acid, oxaloacetic acid, oleic acid, aminolevulinic acid, 2-amino-4-guanidinooxybutyric acid, angelic acid, galacturonic acid, carbamine Acid, icosatrienoic acid, formic acid, allyl formate, isobutyl formate, icosanoic acid,
Isopentyl formate, glucuronic acid, iduronic acid, crotonic acid, chloroisocrotonic acid, isocrotonic acid, acetic acid,
Dihydrolipoic acid, ethyl crotonic acid, diphenylacetic acid,
Dimethoxyphthalic acid, ethylhydroxybutyric acid, succinamic acid, stearic acid, stearolic acid, sorbic acid,
Tiglic acid, thyroxine, decanoic acid, tropic acid, lactic acid,
Hydroxyisobutyric acid, hydroxyvaleric acid, pyruvic acid,
Butyl acetic acid, butyl hydroperoxide, brassic acid, propiolic acid, pyropionic acid, bromoisovaleric acid,
Bromoisobutyric acid, bromopropionic acid, hexanoic acid, hexenoic acid, petroselinic acid, heptadecanoic acid, heptanoic acid, areanilic acid, maleamic acid, maleamic acid, mycolic acid, myristic acid, methacrylic acid, methylvaleric acid,
Aliphatic monocarboxylic acids such as methylthioacetic acid, methylbutyric acid, mevalonic acid, melicinic acid, mercaptoacetic acid, iodoacetic acid, lauric acid, ricineradic acid, ricinoleic acid, linoleic acid, linolenic acid, aconitic acid, oxalosuccinic acid, oxoglutaric acid , Adipic acid, calcein,
Carboxyphenylacetic acid, acetoxysuccinic acid, carboxycomeronic acid, camphoronic acid, isocampholonic acid, glutaconic acid, glutaric acid, isocitrate, crocetin,
Succinic acid, phthalic acid, fumaric acid, isosincomeronic acid,
Diethylenetriaminepentaacetic acid, isophthalic acid, citramalic acid, dinicotinic acid, itaconic acid, dibromosuccinic acid,
Dichlorosuccinic acid, ethylmalonic acid, dimethylsuccinic acid, oxalic acid, tartaric acid, cinchomeronic acid, sulfonyldiacetic acid, sebacic acid, tartronic acid, desoxolic acid, tetrachlorophthalic acid, tetrahydroxysuccinic acid, tetramethylsuccinic acid, terephthalic acid , Trimesic acid, trimellitic acid, naphthalic acid, nitrophthalic acid, bixine, hydroxyisophthalic acid, hydroxyphthalic acid, planitic acid, hydroxymethylpentanedioic acid, pyromellitic acid, phenylsuccinic acid, propanetricarboxylic acid, bromosuccinic acid, bromofumaric acid, bromo Maleic acid, hemimellitic acid, pelargonic acid, berberonic acid, benzenehexacarboxylic acid, benzenepentacarboxylic acid, maleic acid, malonic acid, mesaconic acid, mesotartaric acid, mesooxalic acid, methylisophthalic acid, methyl Succinic acid, methylmalonic acid, mercaptosuccinic acid, mellophanic acid, peroxy phthalic acid,
Malic acid, lutidine acid, polycarboxylic acids such as leukotriene, methylanthranilic acid, mercaptobenzoic acid,
Iodobenzoic acid, benzylbenzoic acid, benzamidobenzoic acid, acetylbenzoic acid, ethylbenzoic acid, opianic acid, orseric acid, acetamidobenzoic acid, carboxyoxanilic acid, azoxydibenzoic acid, chlorobenzoic acid,
Chloroperbenzoic acid, anisic acid, gentisic acid, diaminobenzoic acid, shikimic acid, aminobenzoic acid, dihydroxybenzoic acid, dibromobenzoic acid, benzoylbenzoic acid, aminonitrobenzoic acid, dimethylaminobenzoic acid, dimethylbenzoic acid, benzoic acid , Sulfobenzoic acid, terephthalaldehyde acid, isophthalaldehyde acid, trichlorobenzoic acid, trinitrobenzoic acid, isopropylbenzoic acid, trihydroxybenzoic acid, trimethylbenzoic acid, toluic acid, toluoylbenzoic acid, nitrobenzoic acid, vanillic acid, idrazoni Benzoic acid, hydroxybenzoic acid, hydroxytoluylbenzoic acid, piperonylic acid, phenoxybenzoic acid, fluorobenzoic acid, veratromic acid, protocatechuic acid, probenecid, bromobenzoic acid, bromoanthranilic acid, aminocinnamic acid Isopropylcinnamic acid, oxanilic acid, arecaidine, carboxycinnamic acid, cinnamic acid, alloxanic acid, ketocyclohexanecarboxylic acid, anthraquinonecarboxylic acid, cyclobutanecarboxylic acid, anthracenecarboxylic acid, cyclopropanecarboxylic acid, isonicotinic acid, cyclohexanecarboxylic acid Acid, cyclopropanecarboxylic acid, isonicopentinic acid, cyclohexanediaminetetraacetic acid, cyclohexanedicarboxylic acid, ibuprofen, cyclohexenedicarboxylic acid, cyclopentanecarboxylic acid, indomethacin, indoleacetic acid, cyclopentanedicarboxylic acid, dimethylfurancarboxylic acid,
Cincophen, galloyl gallic acid, tranexamic acid, nitrocinnamic acid, hydroxycinnamic acid, methoxycinnamic acid, hydroxyhydrocinnamic acid, phenylcinnamic acid, ferulic acid, bromocinnamic acid, hesperitic acid, gallic acid, methylcinnamic acid Aromatic carboxylic acids such as, etc.,
Ursodeoxycholic acid, ellagic acid, orotidine, orotic acid, camphanic acid, quinic acid, hydroxyproline, ethicholanic acid, caulmoogluric acid, carnosine, carbazole acetic acid, quinoline carboxylic acid, quinolinic acid, quinoline dicarboxylic acid, coumaric acid, chlorophenoxy Acetic acid,
Chenodeoxycholic acid, cholanic acid, cholic acid, santonic acid, dihydroorthoic acid, succininal acid, thiophenecarboxylic acid, tetrahydrofolate, dehydrocholic acid, terpenylic acid, terevic acid, dominoleic acid, dopa, thromboxane, naphthylacetic acid, naphthoic acid, Nalidixic acid, nitroquinadylic acid, nitrophenylpropiolic acid, nicopetinic acid, ruconanoic acid, dopaquinone, hyodeoxycholic acid, hydroatropic acid, hydroxyisopropyltoluic acid, hydroxycyclohexanecarboxylic acid, hydroxypyronecarboxylic acid, hydroxypyronedicarboxylic acid, hydroxyphenylacetic acid , Hydroxyphenylpropionic acid, biphenyldicarboxylic acid, pipecolic acid, piperic acid, pimaric acid, pyridylic acid, pyroglutamic acid, pyrrolic acid Bonic acid, pyronecarboxylic acid, pyronedicarboxylic acid, phenylanthranilic acid, phenylcarbamic acid, phenylglycidic acid, phenylacetic acid, phenylthioacetic acid, phenyllactic acid, phenylpyruvic acid, phenylbutenoic acid, phenylpropiolic acid, phenylbutyric acid, phenylene2 Acetic acid, phenolphthalin, fencoric acid, fusidic acid, proteroic acid, furancarboxylic acid, furandicarboxylic acid, furic acid, fluorescein,
Fluorophenylacetic acid, prostaglandin, prostacyclin, bromomandelic acid, hemopyrrole carboxylic acid, benzidine carboxylic acid, benzylidenemalonic acid, benzylic acid, benzoylacrylic acid, benzoyloxyacetic acid, benzoyloxypropionic acid, benzoylformic acid,
Benzoylacetic acid, benzoylpropionic acid, benzophenonecarboxylic acid, benzofurancarboxylic acid, podocarpic acid, homogentisic acid, mandelic acid, muricholic acid,
Methyl dopa, methylphenylacetic acid, methylfuran carboxylic acid, methyl red, mefenamic acid, resergic acid, lithocholic acid, lipoic acid, reserpine acid, retinoic acid, levopimaric acid and the like. In particular, it is preferable to use 2-hydroxy-phenylmethylacetic acid ester in which R ₃ in the compound of the general formula II forms an ester bond with acetic acid and R ₄ is a hydroxyl group.

As the compound having a hydroxyl group represented by the general formulas I and II, any compound having at least one hydroxyl group can be applied. For example, isooctyl alcohol, ethylhexanol,
Isophytol, ethylpentanol, oxaloacetic acid,
Isobutyl alcohol, oxalosuccinic acid, isobutylene glycol, glycolamide, ethylaminoethanol, geraniol, bromoethanol, ethylhydroxybutyric acid, santalol, bloomobutanol, butylamineethanol, dimethylhexanol, dimethylpentanol, sphingosine, bromopropanol, sorbin alcohol , Decanol, propanol, triacontanol, trichloroethanol, trichloroethoxyethanol, nitroethanol, nerol, nonanol, hydroxypentanal, hydroxymethylpentanal, butanol, butenol, hexadecanal, hexanol, hexenol, heptadecanol, heptanol , Benzaldehyde oxime, pentanol, pentadecano Le, methyl butanol, methyl butyrate down ol, methyl pentanol, methoxypropanol, mercaptoethanol, iodoethanol, Rinaoru, rhodinol, lauryl alcohol, myristyl alcohol, palmityl alcohol, stearyl alcohol, behenyl alcohol, hexadecyl alcohol,
Oleyl alcohol, isostearyl alcohol, hexyldecanol, octyldodecanol, cetostearyl alcohol, 2-decyltetradecinol, methanol, ethanol, cetanol, aliphatic monohydric alcohols such as acetoin, anthracene diol, quinoline diol, glyoxime, Glyceraldehyde, anthracenol, sedheptitol, propanediol, inositol, usnic acid, urushiol, ursodeoxycholic acid, ethylboronic acid, diethanolamine, diethylpropanediol, diethylene glycol, diethoxypropanediol, cyclohexanediol, cyclohexanedione, cyclohexanetriol , Dihydroxyoctadecanoic acid, dihydroxycinnamic acid, dimethylcyclopentane All, dimethylpropanediol, dimethylbenzenediol, tartaramide, thioglycerin, triethylene glycol, nitropropylpropanediol, butanediol, butynediol, hexanediol, pentanediol, pentanetriol, pentanepentol, ethylene oxide, ethylene glycol, Diethylene glycol, triethylene glycol, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin,
Pentaerythritol, threitol, arabitol,
Xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol,
Polyhydric alcohols such as methanediol, methylbutanediol, monoacetin, and rhamnitol, agarobiose, N-acetylgalactosamine, N-acetylglucosamine, N-acetylneuraminic acid, N-acetylaninosamine, avequose, arabinose, altrose, allose , Iduronic acid, maltose, idose, inulin,
Erythrose, oleandrose, galacturonic acid, galactosamine, galactose, xylose, xylobiose, quinobose, glycal, perseitol, ketooctose, glucuronolactone, glucuronic acid, glucosamine, glucose, gluconolactone, glucuronic acid, gulonic acid, gentianose, gentiobiose, Kojibiose, chondroitin, chondroisin, digitalose, digitoki sauce, simarose, sucrose,
Stamyose, streptoose, sedoheptulose, cellotriose, cellobiose, sophorose, solasonine, solanine, sorbose, talose, turanose, deoxyglucose, deoxygluconate, deoxyribose, desosamine, tetramethylglucose, tetramethylgluconate, trimethylglucose, threose,
Trehalose, nigerose, neuraminic acid, hyalobiuronic acid, biopterin, fucose, psicose, planteose, fructose, mycosamine, maltose,
Maltotriose, maltonic acid, mannose, mannuronic acid, muramic acid, methylglucopyranoside, methylfructofuranoside, methylmanopyranoside, melibiose, melezitose, lactulose, lactose, raffinose, laminaribiose, rhamnose, lyxose, ribulose, Sugars such as ribose and rutinose, azauridine, azaguanine, aspidine, acetamidophenol, azodiphenol, aminonaphthol, anis alcohol, aminonitrophenol, anilinophenol, aminophenol, anole, aminocresol, aminodichlorophenol, acrinol, acrino Flavin, aminoresosinol, arianin yellow, alizanin blue, allylphenol, alkanenin, isoeugenol Isovanillin, indophenol, ethylphenol, ethenyl phenoxy phenol, eugenol, octopamine, olivetol, orcinol, orsellinic acid, orthocaine, catechol,
Cavibetol, carvacrol, xylenol, gingerol, guaiacol, cresol, cresol,
Chloranilic acid, chlorophenol, chloronitrophenol, gentisic acid, kojic acid, coniferyl alcohol, p-cyanophenol, diaminophenol, diethylstilbestol, diosphenol, shikimic acid, dinitrocresol, dinitroresorcinol, dihydroxyacetophenone, Diphenylethanol, dibutylphenol, ibutylmethylphenol, galloyl gallic acid, thymol, difluorophenol, dibromophenol, dibromonitrophenol, dimethylpropylphenol, dimethoxyphenol, syringaldehyde, stifnic acid, tyramine, tetrachlorohydroquinone, tetranitrophenol , Tetrahydroxybenzoquinone, tetrahydroxybenzophenone, tetrabromocresol, tet Methylbenzenediol, totarol, dopamine, triaminophenol, triisopropylphenol, trichlorocresol, trichlorohydroquinone, trichlorophenol, trinitrocresol, trinitrophenol, trihydroxyacetophenone, trihydroxydimethylbenzene, trihydroxytriphenylmethane, trihydroxy Benzophenone, tribromophenol, trimethylphenol,
Trimethylbenzenetriol, nitrophenol, nitroresorcinol, vanillin alcohol, vanillin,
Picramic acid, picric acid, hydroxyacetophenone, hydroxyazobenzene, hydroxyephedrine, hydroxystyrene, hydroxyhydroquinone, hydroxybenzaldehyde, hydroxybenzenesulfonic acid, hydroquinone, pyrogallol, butylphenol, fluorophenol, bromonitrophenol, bromophenol, bromoglucinol, hexyl Resorcinol, benzylphenol, benzenetetraol,
Benzenehexaol, pentachlorophenol, pentamethylphenol, hordenine, methylaminophenol, methylbenzenediol, methoxyphenol,
Phenols such as iodophenol and resorcinol, acacetin, apigenin, anthocyanidin, aphidicolin, agnosterol, epicatechin, catechin, galangin, quercetin, glatiogenin, genistein, kaempferol, dihydroxyanthraquinone, dihydroxyanthrone, daidzein, naringenin, flavonol, flavonol Hesperetin, myricetin,
Morin, ramnetin, luteolin, flavonoids or terpenoids such as rotenone, ascorbic acid, dihydroascorbic acid, ergocalciferol, calciferol, pyrocalciferol, dehydroretinol,
Retinol, pyridoxine, pyridoxal, pyridoxamine, riboflavin, tocopherols, tocotrienol, vitamins such as aminomethylnaphthol, and others, oxythiamine, oxytetracycline, oxine, onoserine, oleanolic acid, oleandrigenin, orotidine, casinols, cafestol, gamabuhogenin, Galantamine, cardenolide, carveol, carbostyrene, carbomenthol, campesterol, gitoxigenin, quinic acid, quinalizarin, cuminyl alcohol, curcumin, chromotroproic acid, chloramphenicol, chlorogenic acid, coprostane, cortisone, corticosterone, cholecalciferol , Cholesterol, cholesterol, dienstrol, diolein, digitoxygeni , Cyclobutyl methanol,
Cyclopropanol, cyclopropylmethanol, dihydroanthrol, cyclohexanol, cyclohexylmethanol, cyclopentanol, cyclopentanediol, sitosterol, dinitronaphthol, dihydroxycoumarin, dihydroxynaphthoquinone, dihydroxybenzophenone, dihydroxybenzoquinone, dihydroxypentadecylbenzene, dihydroxymethylanthraquinone , Dihydrotestosterone, dimethylcyclohexanol, dimethylcyclopentanol, dimosterol, cinnamyl alcohol, squaric acid, stigmasteranol, stigmasterol, strofatidine, spinasterol, zeatin, cedrine, sobrenol, solanidine, taurocholate, thiochrome , Tilcator, tyloxy , Tsuyaprisin, deoxycholic acid, deoxycorticosterone, deoxycortisol, deoxypyridoxine, dexamethasone, desoxymethasone, testosterone, desmosterol, tetrahydroxyanthraquinone, tetrahydronaphthol, tetrahydrofurfuryl alcohol, dehydroepiandrosterone, dehydroergosterol , Dehydrocorticosterone, dehydrocholesterol, tevenin, terpionaire, terpinol, trisaminophenylmethanol, trishydroxypropylamine, trishydroxymethylaminomethane, trihydroxyanthraquinone, trihydroxymethylanthraquinone,
Triphenylmethanol, naphthalene diol, naphthalene triol, naphthyloxyethanol, naphthol, naphtholsulfonic acid, nandrolone, nitrocresol, nitronaphthol, nitrobenzyl alcohol, ninhydrin, aminobenzyl alcohol, ephedrine, allopurinol, oxanthon, equilin,
Echirenin, ecdysterone, isopulegol, isomenthol, ungernine, ungminolin, umbelliferone, ethynylcyclohexanol, ecdysone, estradiol, estriol, 17 ethynyl estradiol, ethynyltestosterone, epiandosterone, epicoprostanol, epicholestanol, epicholesterol, Ergostenol, ergosterol, euphorth, β-eudesmol, thioergosterol, noradrenaline, norethisterone, norpsoidephedrine, basicin, paramethasone, pantolactone, bishydroxyethyl terephthalate, bishydroxyphenylpropane, bishydroxymethylbenzene, bis Methylphenylmethanol, hydroxyanthraquinone, hydro Cyantron, hydroxyacetophenone, hydroxyiminonitroethane, hydroxyiminonitropropane, hydroxyquinaldine, hydroxynaphthaldehyde, hydroxynaphthoquinone, hydroxypyridine, hydroxyhexanal, hydroxybenzyl alcohol, hydroxymethylpyrone, hydroxybenzotriazole, hydroxybenzophenone, hydroxymethoxy Cinnamaldehyde, hydrocortisone, naphthalene diol, biphenyl, pyridoxal, pyridoxine, fetrol, phenacyl alcohol, phenanthylene diol, phenanthrol, phenylethanediol, enilbutinol, phenylfluorone, phenylpropanol, phenethyl alcohol, phenoxyethanol, pheno Ximethanol, phenoxypropanol, phenoxybutanol, phenoxypentanol, phenolphthalein,
Ferginol, Fusin, Pseudoephedrine, Buphogenin, Buhotalin, Buhotenin, Fluorenol, Furfuryl alcohol, Purprogalin, Pregnenolone, Pretonisolone, Prednisone, Prorotoveratridine, Prolotoverin, Propranol, Dihydrochalcone, Hexamethylol melanin, Hexestrol
Hexobarbital, betamethasone betulin, hematoxylin, hematein, benzyl alcohol, benzyloxyethanol, benzhydrol, benzoyl resosinol, benzoin oxime, benzoquinone dioxime, benzohydroxamic acid, homokedolinin, formaldehyde oxime, macululin, mandelonitrile, Metathebinone, methylarsonic acid, methylephedrine, methylcarbostyryl, methylcyclohexanol, methylcyclopentanol, methyltestosterone, methylbenzyl alcohol, methylenedioxybenzyl alcohol, mevalonolactone, mephenesin, mentenol, menthol, laudanin, laudanocin, lactaldehyde , Lacmoid, lanosterol,
Examples include rapacoic acid, rutin, lupeol, lumisterol, rosicinic acid, reductic acid, reticuline, lobeline, loberanidine, androstandiol, androsterone, and the like. In particular, use of 2-hydroxymethyl-phenyl-β-D-glucopyranoside in which R ₃ in the general formula II is a hydroxymethyl group, and R ₄ forms an ether bond with the hydroxyl group at position 1 of β-D-glucose. Is preferred.

The metal ion forming a salt with the compound represented by the general formula I includes, for example, Li, Na, K, Rb, Cs, B
e, Mg, Ca, Sr, Ba, Mn, Fe, Cu, Co, Ni, Zn, Cr, A
Examples thereof include l, Mo, and Ag. In particular, it is preferable to use sodium salicylate, which is a Na salt.

At least one compound selected from salicylic acid or a derivative thereof or a salt thereof of the present invention, and / or at least one compound selected from salicyl alcohol or a derivative thereof is contained as a melanin production promoter. In addition to the main purpose, it can be further contained in the cosmetic composition, but the content is not particularly specified, and the type, quality, expected degree of action of the melanin production promoter or the cosmetic composition In general, it can be used in a concentration range of 0.0001 to 50% by weight, and particularly in a concentration range of 0.001 to 10% by weight, based on the total amount of the preparation.

The melanin production promoter or cosmetic composition of the present invention may be in any dosage form, such as capsules, powders, granules,
They can be used in the form of solids, liquids, gels, air bubbles, emulsions, creams, ointments, sheets and the like.

The field of application is, for example, applicable to all kinds of external preparations (including preparations for animals), and specifically, ampules, capsules, pills, tablets, powders, granules, solids, 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (eg, cosmetics) in suitable forms for use as liquids, gels, bubbles, emulsions, sheets, mist, sprays, etc. Basic cosmetics such as water, emulsions, creams, ointments, lotions, oils, and packs, facial cleansers and skin cleansers, massage agents, cleansing agents, hair removers, depilatory agents, shaving treatments, after-shave lotions, pre-shows Lotion, shaving cream,
Makeup cosmetics such as foundation, blusher, eyeshadow, eyeliner, and mascara, cataplasms, plasters, tapes, sheets, patches, aerosols, etc.), 4) medicated or / and applied to the scalp / hair Cosmetic preparations (e.g., shampoos, rinses, hair treatments, pre-hair treatments, permanent liquids, hair dyes, hair styling agents, hair tonics, hair growth and fostering, cataplasms, plasters, tapes, Sheet agent,
Patches, aerosols, etc.), and 5) bath preparations to be poured into bath water for use.

The method of adding to the melanin production promoter or the cosmetic composition of the present invention may be added in advance or during the production, and may be appropriately selected in consideration of workability. good.

The melanin production promoter or the cosmetic composition of the present invention may further comprise, in addition to the above essential components, a moisturizing action, a cell activating action / metabolism activating action, an antioxidant action, and active oxygen. Extinction action, UV protection action, astringent action,
Ingredients and additives having an anti-inflammatory action, an antibacterial action, a blood flow promoting / stimulating action, an anti-androgen action, an enzyme (elastase, collagenase, etc.) activity inhibitory action, a keratolytic action, and the like, or exhibit multiple actions thereof Extracts and metabolites derived from plant-based materials, animal-based materials, microbial-based materials, other natural-product materials, etc., as well as melanin-producing accelerators or cosmetic compositions are preferably used. By arbitrarily selecting and using the components, additives, and the like, it is possible to provide an excellent cosmetic composition having various functions in addition to the melanin production promoting action. Although the content in the preparation is not particularly limited, a concentration range of 0.0001 to 50% by weight is generally effective.

(1) Moisturizer Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene Glycols, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, polyhydric alcohols such as maltitol, gum arabic, benzoin gum, Dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum Kyarobugomu, Quincy de, agar, casein, lactose, fructose, sucrose or an ester thereof, trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene such as ethylene oxide (C2-C4)
Oxide-added hydroxyalkyl (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine, dermatan sulfate,
Water-soluble polymers such as keratan sulfate, pyrrolidone carboxylic acid or a salt thereof, sodium lactate, mini sasanishiki extract, natto metabolite, natto extract, luffa water, birch (birch) or red pine sap.

(2) Cell activating agent / metabolism activating agent Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U Vitamins such as valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine,
Cystine, tyrosine, proline, hydroxyproline,
Amino acids such as aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid, glycolic acid, citric acid Α-hydroxy acids such as malic acid, tartaric acid, lactic acid, succinic acid, photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin,
Pentadecanoic acid glyceride, linolenic acid or derivative thereof, eicosapentaenoic acid or derivative thereof, docosahexaenoic acid or derivative thereof, estradiol, ethenyl estaradiol, etc., lactic acid bacteria extract, placenta extract, reishi extract, spleen extract, thymus extract, yeast extract , Fermented milk extract, plant extract (aloe, ogon, horsetail, gentian, burdock, sicon, carrot, hamamelis, hop, yokunin, odorisou, assemblage, squid, tokinsenka, amacha, hypericum, cucumber, tachikosou, rosemary, parsley )etc.

(3) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, propolis, β-carotene,
Plant extracts (cultured sesame cells, amateur, hypericum,
Hamamelis, Clove, Melissa, Emperor, Birch, Salvia, Rosemary, Minami Amami, Agetsu, Ginkgo, Green Tea), etc.

(4) Active oxygen scavenger SOD, catalase, glutathione peroxidase,
Bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or derivatives thereof, and the like.

(5) UV protection agents benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives,
Tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dibenzo Oxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin and the like.

(6) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compounds) etc.

(7) Anti-inflammatory agent ictamole, indomethacin, kaolin, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof and derivatives thereof, glycyrrhetinic acid Or a salt thereof and a derivative thereof, mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, pantothenate such as calcium pantothenate, pantoenyl ethyl ether or a derivative thereof, and a salt thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid , Licorice extract, sicon extract, age extract, propolis etc.

(8) Antibacterial agent acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salash Powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, propionic acid or a salt thereof, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m -Xylenol, p-chloro-
m-cresol, thymol, phenethyl alcohol, o-
Phenylphenol, Irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol,
Zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (lauryl Sodium sulfate, potassium lauroyl sarcosine, etc.), cationic surfactants (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin, propolis and the like.

(9) Blood flow enhancer / stimulant Vitamin E or a derivative thereof, cepharanthin, carpronium chloride, minoxidil, pepper tincture, nonylate vanilamide, cantaristin tincture, ginger tincture, peppermint oil, l-menthol, camphor, Benzyl nicotinate, cinnarizine, tolazoline, acetylcholine,
Verapamil, itctamole, α-borneol, cyclandate, nonylate valenylamide, capsaicin,
Gingerone, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract and the like.

(10) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones, etc.

(11) Enzyme (elastase, collagenase, etc.) activity inhibitor Diisopropyl fluorophosphate, plant extract (Ougon, Hypericum perforatum, Clara, Mulberry leaf, Calypt, Gennoshoko, Comfrey, Salvia, Agaricus japonicus, Bodaiju, Botanpi) , Seaweed extract and the like.

(12) Keratolytic agent Resorcin, lactic acid, urea, guanidine, ethanolamine and the like.

(13) Various ingredients or additives derived from plant-based materials, animal-based materials, microbial-based materials, and other natural product materials These are conventionally performed according to the type and form of the product to be added. Processing (for example, arbitrarily select grinding, milling, washing, hydrolysis, fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc., Combined processing) and arbitrarily select from various materials.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, etc. Select from alcohols, lower alcohols such as butanol and isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or water-containing polyhydric alcohols, acetone and various organic solvents such as ethyl acetate. It is desirable to use one or a mixture of two or more of these. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after the extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

Specific plants (crude drugs) as raw materials include:
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsu-la-fuji (Kibo), Aotenma, Acacia, Akasho (Akasho), Akasuguri (fruit), Red clover, Red grape, Akaminoki (Logwood), Akamegawiwa (Red bud), Akaminokane or Akane Akane or Akane (Akane) Grass roots), red pheasant or geese (land yellow),
Agi (Awei), Aki larch, Akinire (Lolyu bark), Aguay Guacu, Aguahe (Wolverine palm), Akebi
(Kidori), Asa (Jin Asako), Malva Asagao or Asagao
(Toshiko), hydrangea (hydrangea), ashitaba (morning leaves), azuki (red azuki bean), asunaro, acerola, asenyaku (asenyaku), acira (shokuyoukanna), anise, abiu, abiulana, rape and abemaki `` fruit '' ,Avocado,
Ama, Amacha (Amacha), Amachaworu, Amadokoro (Jade bamboo), Amana (Kojingi), Amaranthus (Hyuyu, Hagaito, Himogeito, Senninkok, Sugimorigeito,
Hosoagaitou, Aoagetoi, Haribiyu, Aosuzuran, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish), Aristolomelia (Urizusensen), Arcana (Alcanna), Algarrobo (Cave), Altea, Arnica, Alpinia or Katsumadai
(Sorghum), aloe (lux), aloe vera, angelica, apricot or hon apricot (almond jelly), ansokko (benzoic acid), yellow sapote, scutellaria (biliary head), epimedium or primrose (inyokaku), rush
(Wicked grass), Knotweed (Tiger root), Yew (1st), Strawberry,
Figs (fructose `` fruits and leaves ''), Ichihatsu (primary), ichibi (winter aoiko), Ichiyakusou (one medicinal herb), ginkgo (ginko `` seed and leaves ''), Itohimehagi (enshi), carob, and locust bean (Telexa) , Inubeil (Honagainubiru), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou, nettle, ylang-ylang, iwa-tobacco
Iwahiba or iwamatsu (makikashiwa), oolong tea, fennel
(Fenka), Wheat (Chibusanoki), Ukiyagara (Sanryong), Uguisukagura `` fruit '', Himeukikyo, turmeric (Utsukin), Duckweed (buoying), Usubasaishin or Keirinsaishin or Oushusaishin (spicy), Usveniaoi , Foxglove, euphoria, moray eel
(Summer hay), Udo or Shishiudo (Kang-Kang, Independent, Tang-Kun), Unyadegato (Unkaria, Cat's Claw), Uba Tea, Ume (Oumei `` seed, pulp ''), Vladimir, Uwaurushi
(Kusaco peach), Unshu mandarin orange (Chen skin), Unboku,
Estragon, Ezokogi (Ezo Goka), Ezo lily of the valley,
Echinashi (Hoshibamurasakibarengiku), Enishida, Enokitake (Enotake), Ebisugusa or Cassia Tora (Keyoshiko), Elcampre, Elderberry `` fruit '', Elemi, Elingii or Pre Lotus Elinge, Ende
(Gossip, Sophora rice), ogre or Kibana-ohgi (Astragalus), Narco lily or Kagi Kurumabanaruko lily (Yoshisei), Ohhisasanoyuki or Sasanoyuki, Oren (Yellow), Ogata Hawken, Ookarasuri (Karokon), Ooguruma (Civil) , Ootsuji rafuji (self-defense), Psyllium (vegetative child, vegetative grass), psyllium thistle (Keju sashimi, bald man), eucalyptus (Haruko), pygmy cactus, pygmy pygmy or ophylla (white jitsu), pygmy pygmy (banaba), Beetle shabushi `` fruit '', giant beetle (grain sperm), beetle catechu, beetle hawthorn or hawthorn (mountain fry), barley
(Barley), oka, okazeri (snake bed), okra `` fruit '', oguruma (turnover), okururi higotai (yushu sashimi, indigo sashimi),
Panax ginseng or horseshoe ginseng (carrot), Hypericum perforatum or Hypericum perforatum or St. John's wort (brother's cut grass), Odorikosou (intermittent), Onamimi (blue ears),
Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma), Oniyuri or Sasasayuri or Hakatayuri (Yuri), Onoeran, Ononis, Halibut
(Hihayu), Ominaeshi (losing sauce), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch biyu, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, pericarp," Yellow), cacao "fruit, peel, seeds", kaki (persimmon "leaf"), kagikazura
(Hooks of Choto), Persimmon or Kantriso (Rensenso), Kakiran, Gaku hydrangea, Cassia, Kasinaki (Kozou `` fruit ''), Kajutsu (Shazajutsu), Kashiwa (Yanagi, Yuzuha), Kascarilla, Kascara sagrada , Gypsophila, gypsophila, kanikusa (kinsato), kaniwa, carnation, valerian (valerian root), hippopotamus, birch or weeping birch (white birch),
Gerbera, Pumpkin, Capoknoki `` seed '', Kahoku Sansho (shopper), Gama (bamboo), Chamomile or Roman chamomile, Kamiyatsude (weed), Kamkamu (duckling), Color, Karakakeman, Ragusuri or Shinakorasuri
(Our melon), crow squirrel (midsummer), oats, guarana `` seed '', karahoo (thick), karaya, garyu, karin
(Gourd melon), Garcinia, Kawamidori, Kawara Psycho (Koryosai, Hakubaku), Kawazusha, Kawaratake, Kawaranadeshiko (Ishitake) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawaranginjin (Blue Gourd), Kawamuragi (Inchinchinko) , Kansui
(Sweet), licorice (licorice), cantaraasa, candelilla,
Canto, canna, canlan, raspberry (ezo strawberry,
Dutch strawberry, shrimp strawberry, pear strawberry, maple strawberry, European strawberry), kiwi `` fruit,
Leaves, chrysanthemum cucumber (urorone), kikyo (bellflower, bellflower root), chrysanthemum (chrysanthemum, chrysanthemum, koseki nogiku),
Kikutaniki, Catalpa (Azumitsu), Rumex (Yotei), Pheasant (Kikomi), Kizuta, Kidachi Aloe, Kidachihakka, Kina, Kinoki (Shincona, Akakinoki), Quinua (Kinoa), Kihada (Huangbashi), Gymnema sylvesta, Kimmenkaku, Cabbage, cabbage "immature fruit", caraway,
Cucumber, Gyoryu (Nishikawayanagi, Ichiyanagi), Kiraja Saponaria, Kiraya, Kiranso (Kinkan grass), Kumquat `` fruit '', Ginsekai, Kimbusen, Kinma, Kinmizukiki (Sengaku grass), Kinran, Ginran, Kinryohen,
Guapeva Vermelha, Guava "fruit", guayule, Quercus infectria (gallicate), cucuin nut, cugenumaran, wolfberry (cucumber, cucumber, cucumber leaf,
(Skin bone), Cedar grass (Tenmen Fuyu), Kudzu (Kakkon), Camphor tree, Gooseberry `` fruit '', Xining ginseng
Kutiti River, Gardenia (Gardenia), Kunugi (Bokusou), Kupuas, Kubeba, Kumazasa, Kumatsuzura (Epispermia), Clara (Bite), Cranberry "Fruit", Chestnut "Seeds, Fruits, Astringent Skin", Curculigo Latifolia `` Fruits '', grapefruit `` fruits / leaves '', buckthorn, stag beetle (needs rescue), turtle crab or kurobana chick sprouts or cypress (extended life grass), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi),
Kaigai (Thorndust, Ikutakeho), Celosia (Rooster, Chicken),
Gekkavidin, bay (laurel), Kenashisarutibara (Tsuchukuryo, Yamakiko), gentian, gennoshoko
(Old tongue grass), Kemponashi (Kigushi), Koukisekikoku, Kishumitsukan (Koji, Tachibana, Oveni mikan, Fukuromikan, Sagamikouji, Ponkan, Santara (Tachibana bark)), Koushinbara (Monthly flower), Kosuihakka, Kozo `` Fruit '' , Kocha (tea), Kouhone (river bone), Kohon
(Straw book, Kara straw book), Koryang, Kouryokyo (Kora Kyo), Cilantro `` fruit '', Kourouen (Kohren), Koganebana (yellow gon), Cowberry (Koshibachi), Coco palm `` Fruit '',
Goshuyu (goshuyu), Goshoichigo (covered bonko), pepper
(Pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot spring), burdock (burdock,
Burdock), kobotdur, sesame (sesame), sesame seeds (gensin), garnish (gomiko), sanekazura or binankazura or matsubusa, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata " Seeds ", cola
Vera “seed”, colony lya, fenugreek “fruit”, colombo, conzlango, kelp, konjac, comfrey
(Final barn grass), sisal (sisal asa), saihairan, sakaneran (ezosakaneran), saxima button or syna button or cinnamon (weird sen), cherry
(Ooshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura `` Leaf, flower, fruit, bark (cherry bark) ''), cherry, pomegranate, sasa, sasabagin , Sage Modaka (Sawaka), Sweet Potato, Sugarcane, Sugar Beet, Sanebu Jujube (Satsuma Natsume), Saffron (Safflower, West Safflower), Sapodilla, Sapotea Marillo, Pomelo "Fruit", Sabonsou, Salmonberry "Fruit", Sarasin
(Masahima), Saranshito (Sand Ai Sashimi), Salvia (Sage),
Sawagikyo (Yamakona), Sawagurumi (Yamawomo), Sankaku cactus, Sangre degrad (Croton), Sansouyousou, Sanshin ginseng (Sanjin ginseng), Sanshuyu (sanshuyu), Sanshoyu (sansho), Sunzucon (Yamato) Root), shea
(Karite), Cyano (fruit), Shiitake (Shiitake), Sion
(Shiwon), Red-spotted squirrel, Shikunshi (Kimiko), Perilla or Aozo or Chirimenji or Kamenjiso (Shiyo-leaf, Shiso-so), Rosewood, Shinanoki, Shinanohonoki, Chinese forsythia (reamous forsythia), Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshirohimeji) Bunashimeji, honjimeshi, shirotamogitake), shimokuren (hot spring), shimotsukesou, potato, peonies (shakuyaku), shajin (shasan), jasmine (matsurika), janohige (wheat gate winter), shukukonemisou, shukushamitsu (sunin, Sand), Juzudama,
Palm `` fruit '', Shunran, ginger (ginger), Japanese hydrangea (Tsuneyama), shobu (iris, iris root), shizuku `` fruit '', shirakashi `` seed '', silane (byakyuu), shirogoshi `` seed '', white clover (clover) ), White adzuki bean (chicken bone), White bean iris (Small iris), White bean ivy “flower”, White bean (Nami Tenmi), Cinchona sassilbura, Jinjuge (Mizuka, Mizuka, Shencho flower), Cinnamon, Cinnammum cassia , Watermelon (watermelon), honeysuckle (gold and silver flowers, Shinobi winter),
Sorrel (acid model), swim berry (fruit), star apple, stevia, strawberry (fruit), suzu psycho (Xu Chang Lord), horsetail (Qingi), purslane (horse dent, horse dent), plum berry, sulgaran (Oran), Pinus densiflora `` cone '', larch, vegetation, walnuts, hawthorn, eucalypt, dandelion, horse chestnut (malonie),
Pear `` fruits '', snowy pear, elderflower, elderflower, juniper (juniper, juniper), yarrow (milfoil), rose, foliage, mistletoe, mint, or swordfish (Ishishone), Sekko (Sakura Sekko,
Red-crowned, Red-crowned, Red-crowned, Red-crowned, Red-crowned, Red-crowned, Red-crowned (Dendrobium, Stone), Cedron (Bowshuku-boku), Zeniaoi, Hirohase Nega, Senega, Seri, Sinensen, Sinensen, Sinensen Sengdan, Sennin cactus, Senna `` fruits and leaves '', Senninsou (large tate), Assemblage (drug),
Sengoku, souka (grass), elephant, sosinoubai, buckwheat `` seed '', soybean potato, rhubarb (daisuki), radish, soybean, daidai (orange, kikomi), takasagorurihigotai (southeast indigo), takasaburo (dry lotus) Grass), Takatodai
(Daigei), Takawarabi (Inu), Dark Sweet Cherry `` Fruit '', Tachiaoi, Tachijakosou (Thyme, Hyakuka), Tachidokoro (Hikai), Tachiyanagi, Tamarind `` seed '', Onion, Tamashiba (Shinyi), Taranoki `` Fruit '' , Leaves, root bark '', tarayou (large leaf winter blue, one leaf tea, bitter tea, bitter tea), dahlia (tenjikubotan), tarwi, tanshiuchiwa, tanjin (dansan), dandelion (gakkoei) or white dandelion or moko dandelion, Dammar, Cherry `` fruit '', Tigaya `` fruit, root, bud '', chix carrot (bamboo ginseng), chicory, chancapiedra (Kidachikomikansou), tulip, chocolate nose, Korean blossom (Ohio), Korean cinnamon (Bouyi) ), Artemisia (Aiba), Choreimaitake (Irei), Chorogi, Tsukimiso, Tsukushikaneran, Tsukuritake ( Mushrooms), Tsuchiakebi, Camellia, Camellia, Tsumekusa (lacquer lacustrine), Tsujukusa (Duckling grass), Tsuruazuki (red azuki bean), Tsurutsuchiakebi, Tsurudukudami (Hanshu crow), Tsuruna (Ban apricot), Tsuruninjin (four leaf ginseng), Tsuwabuki, Deiko, Teuchigurumi,
Duberry `` fruit '', tengusa, tencha (tencha), tendai yak (crowd drug), touga (winter melon), toukaizuka,
Capsicum (Pepper), Touki (Toki), Calendula (Marigold), Tonabena (River cut), Maize or Maize hair (Nanban hair), Toad Mochi (Female Sadako), Toudodou or Korean gentian (Ryubile), Tokusa (wood pirates), dokudami (jujutsu), konkon (sore root), toshishi or mamedaoshi or pear, and eucommia (tochu `` bark, leaves,
Roots), ash (qin peel), tomato, tragacanth, triacanthus `` seed '', eustoma, tormentilla, dronoki, troloioi, tongue bean, Niseria berry `` fruit '', potato or yam (herbal medicine), squid
(Butcher Bloom), Naginata Kouju, Nazuna, Rape, Natsume bean or Hatehaki (sword bean), Natsumikan, Jujube (daijutsu), Naniwaibara (Kanakurako), Navena (intermittent), Nameko, Peanut (peanut), Nanten (Nanten) Fruit), Nanban karamushi (ramie), scented violet, nigaki (bitter tree), bitter mugwort (bitter), nutmeg, kei or nikkei or ceylon nikkei or yab nikkei (cinnamon bark) or keishi (keishi),
Grey-eared plover, Chinese chive (Nirako), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nulde (quintuple), leek, nemuki or nebu or nebi or nemlinoki or zigokubana (health), noami ( Daiji), Neubara (real fruit), Nori Kazura (Liao Xiaohua), Nogateto, Yarrow, Nodake (Maehu), Nobara, Nomomo, Pineapple `` Fruit '', Hibiscus (Bussouge, Furinbusouge, Roselle), Hyindou, Hauchiwa, Pau Dosse , Hakama Uraboshi (Bone Crushing), Hakuka Yumato, Hakusan Plover, Hakusen (Ringworm Skin), Huckleberry "Fruit", Hakobe (Horuko), Hashibami (Haruko), Hashiridokoro
(Roth root), basil, lotus (lotus, lotus, lotus), parsley
(Netherland jelly), naked mussel, batata, bee or medake (bamboo boiled), patchouli, mint (lightly loaded, lightly loaded leaves), barley (yokuinin), hanasuge (chimbo), banana, hana mint, hanabishi (situri, shisuturi), vanilla bins , Papaya, mudweed (rat malt), pahalobobo, hub `` whole plant, stem, leaf '', paprika, hamakakiran, hamagou or honey beetle
(Ritsuko Riko), Hamanas (maikai flower), Hamabofu (beach storm), Hamelis, palm, rose (rose), balata,
Balata rubber tree, agaric mushroom (aratake mushroom, white agaric mushroom, usukimori no kasa), haran, pariurus (bamboo jujube), parietalia, harkanran, balsamina (surreale, bitter gourd), harunire (yu bark, yu white bark, yuba), barbasco, harindou Handaikai
(Giant Sea), Breadfruit, Hiogi (Ranker), Lycopodium ginseng (Party), Pecan Nut, Higanbana (Shirubi, Jinjusha Hana), Higuru Madaria, Higotai, Hishi (Hishimi), Pistachio, Beet, Hitotsuba (Stone) Reeds), Aedes fern,
Daisies (daisy), hinata nokozuchi (cow knees), hinio bulbul, hinoki, hiba, castor, sunflower, bell pepper,
Himeuzu (Tamaoi), Himegama (incense bud), Himematsutake (Kawariharatake, Hiromatsutake), Himemyouran, Pimenta `` fruit '', juniper, beakyu, hiyu `` fruit '',
Biloba oi, Hiroha okinagusa (Hakuto Okina), loquat "fruits, leaves, stems", betel nut (large clothes skin, betel nut), puerh tea (pu-cha), scallop (southern rattan), squirrel, serrata Winter leaves), fujibakama (orchid grass), faba bean (tonboshi), fujimokiki (choujizakura, shinbana), grape "fruit, peel, seeds, leaves", beech, beetle
(Cordyceps), Brazilian Licorice, Brazilian Carrot, Black Currant `` Fruit '', Blackberry, Bragnien, Plum `` Fruit '', Flucellaria, Blueberry
(Prunus avium), prunes, floral blanka, blonde psyllium, bundo (green beans), hazelnuts, loofah, hetsukaran, safflower (safflower), henneken, belladonna, berry `` fruits '', percea, perbianberg, pereschia grandifolia, benceisoa Or duckweed (Keiten), boysenberry "fruit", duckweed or elderweed or nendowe or hawakigi kokia
(Skin), Hosairan, Balsam (Hosen, acute child,
Translucent grass), Potteria sapota, Potteria lukuma,
Spinach, boufu (windbreak), spinach, physalis
(Torone), Honoki (Japanese thick and magnolia), Bokeh (Gourd), Hosoba Aburagiku (Biyoku), Hosobaoguruma, Hosovanaokera
(Soujutsu), Japanese beetle (Shinjuku Michiten), Japanese beetle, Bodaiju (bodice tree), button (peony `` flower, leaf,
Stalks, bark ''), buttonpi (peony bark), hops, jojoba, borage (ruriticsha), bordeaux, white berries `` fruits '', hon-oniku (meat jiyo, daitei), hon-sekkoku (iron bark stone, sparrow mountain stone) , Maizulten Nanshaw (Tennan Star), Maitake (Maitake), Ephedra (Masochism), Maca, Macadamia Nuts, Margaret (Mokshungiku), Macri (Seaweed), Magwa (Mulberry White Bark, Bark, Leaves), Magnolia・ Splengeri, Masaranpouba, Masaranzuba de Ceara, Masheira de Boi, Masahua (Tamanousenhallen, Kyukonkinrenka), Matatabi (Kiten Tate), Matsukasa, Pine `` leaves, bark, roots '', Matta Oryo, Matsuhod (Bukuryo), Matico (Cordoncillo), Mayorum (Hanamint), Malvanozadin (Bittersweet), Mulberry "Fruit", Quince, Malein (Below Mow) Watermelon), Mango, Mangosteen, Mansagna (Andesca Mitsure), Mansugurumi, Mandarin `` fruit '',
Mannentake (Lingzhi), Pheasant (Kikomi `` fruits ''), Mishimasaiko (Saiko), Mizuobako or Mizuasagao (Ryugoshi),
Mizokukushi (Hanbe Lotus), Misohagi (Chisatsuna), Mizunyanagi or Shiroyanagi (Henryoku), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Myoga, Miracle Fruit `` Fruit '', Myrrh, Milobalan, Wheatwaragiku, Mukuge (Mokuge) , Mukunoki, Mukuroji (extended skin), Munya, purple (purple root), purple or purple purple
(Purple beads), purple corn, purple purple (Kunming chicken blood wisteria), megakanza opuntica, red seaweed (mother grass), red seaweed, melaleuca, melissa, melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (koshoboku), ilex, mokko (wood incense), maple blossom, peach (peach `` leaves, seeds, flowers, fruits ''), bean sprouts, morello cherry , Moroheiya
(Burlap), yakawamurasakiimo, yakuchi (masuti), cornflower mackerel (cornflower), cornflower mint, yacon, yashabushi (arrow car) or himeyashabushi or giant yashabushi `` fruit, peel, kaho '', yachiyanagi, yatsude (octagonal metal) , Mistletoe (willow parasitism), willow (river willow, twill willow, weeping willow, red willow, pussy willow, dog puppy willow, kinuyanagi, kolyanagi, unryuyanagi, yamayanagi, palm, yamayanagi, obanyanagi,
(European willow, fox, willow tree)
Japanese tobacco (Tsurusui, Tenmei), Japanese pokeweed (land), Japanese alder (Yamaharu), Japanese peach (Yumemei), Japanese sagebrush, Eucalyptus, Yukinoshita (Tiger ear grass), Yucca or flevifolia, Yuzu `` fruit '', lily, Artemisia, mugwort (Aiba),
Rigan (Raimaru), lime `` fruit '', rye, lacanca `` fruit '', raspberry `` leaves, berries '', ratania (clameria), raccoon or shallot (scallop), lavender, longan (longan meat), agave (Aonouragetsu, fukurin) Agave), Ryokucha (green tea), Apple `` Fruits, seeds, leaves, roots '', Gentian, Rubus or Suabisimus (Tenryu), Ruritama thistle (Urajirohigotai, Xinjiang indigo sashimi), Reishi (Lichi, Lichi nucleus), Lettuce (Chisha), Red currant `` Fruit '', Red pitaya, Lemon `` Fruit '', Lemongrass, Forsythia or Chinese forsythia (forsythia), Astragalus, Lumbai (wax plum), Waxy palm, Lokon (Yoshi, Azuki), Loganberry `` Fruit '' , Rosemary (Mannenrou), Rosehip (Nobara), Wasabi, Cottonweed Remokou
(Chiyu) and the like.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), Anaaousa algae (Aosa algae), Algae algae [Aosa algae] Kinds: Kombu (Macambu, Rishikonbu, Hosomekombu, Mitsuikonbu), Wakame, Hirome, Ao-Wakame, Giant kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Klebanoumi prickly pear, Akaba prickly pear, Kona prickly pear, Okina prickly pear, Usuyuki prickly pear, Echinoki prickly pear], seaweed [Red algae: Hijirimen, Maxa (Tengusa), Hiracusa, Oniku , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Junyashinkirinsai, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetsunomata, Hirakotonota, Kotojita
Jareus Banori, Kagius Banori, Siusius Banori, Hyus Banori, Akamomininori] and the like.

Other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaetus, Genus genus Tsutsumo, Artemisia spp .: Artemisia spp.

Cyanobacteria (Genus Lynchium: L., L., L., L .;
(Hassai, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiakashio), etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp.
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakuganusa: Shakuganusa,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russia genus: Ushikenori, Funorinoushike, Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Fudarak, Malbahudarak, Isonohana: Nuracusa,
Cranouraxa, Stinging skull, Hunting genus: Hunting ibis, Hunting genus: Hunting sword, Hunting genus: Chabo kintoki, Hunting ibis, Matsunori, Komenori, Tosakamatsu, Aedes pine, Fushikintoki, Tsunomukade, Nagakinotoki, Scutellariae, Osmanthus Nagaobabane: Nagaobabane,
Genus Funori: Hanafunori, Fukurofunori, Makunori, Kalexigusa: Kalexigusa, Sasamodoki: Hosobanotosakamaki, Hirohanokasakamuki, Yatsudegatatasakamoki, Kurosakamaki, Nezashinosakamukado, Yukasakanookado Modoki,
Genus genus, genus genus: quinohada, genus esculenta: esoteka, tsukasanori genus: enashikarimenia, ootsukasanori, hanagatakarimenija, honooo genus: honoo, genus genus: lyca genus, genus genus, genus nikonobenigo Susqueke Beni, Okamuragusa:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurusilamo, Shiramo, Ogogonori, Mizookonori, Kabanori, Beniogonori, Fucresinori, Murasakikabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori , Genus Amanita: Hachijoenaga, Fushikenori genus: Fushikunori, Namiiwatake genus: Namiiwatake, scorpion genus: Scorpion genus, Occidental genus: Okutsunori, Saimi genus: Itanisa, Saimi, Harigane, Lotus japonicus:
Lotus spiders, genus genus: Ikanoashi, Hosoibonori,
Nobonori, Black Snapper: Black Snapper, Red Snapper: Red Snapper, Hishbukuro: Hishbukuro, Madaragusa: Togemadara, Echimadara, Taoyagousou: Genus Ottawa, Scrophularia , Hirata goat: Hirata goat, Dulce: Dars, Masagoshibari, Anadalus, Uebagsa: Uebagsa, Benifukuronori: Benifukuronori, Fushinagi: Fushitsunagi, Himefushinagi,
Species of the genus Hirohafushi, Snapdragons: Snapdragons, Snapdragons, Species: igis, keiigis, crickets, nigiri, amixa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chrysanthemum Genus: Chrysanthemum, Konohanori Family: Habutaenori, Konohanori, Suzushironori, Usbeni: Usveni, Hasuginu: Hasuginu, Nagakonohanori: Nagakosugino, Genus: suginanu Yareusbanori, Sujiusbanori, Hyusbanori, Usubanorimodoki: Usubanorimodoki, Ayanishiki: Ayanishiki, Ayaginu:
Ayaginu, Dassia genus: Enashidazia, Simadadia genus: Isohagi, Shimadada, Dazimodoki genus: Daziomomodoki, Itogusa genus: Moletogusa, Futoigusa, Macri genus: Macri, Yanaginori genus: Hanayanagi, Yuna, Sanaginori, Mosanyugina, Sasa, Rabbitum : Kurozozo, Kobusoso, Hanezozo, Sozonohana, Hanegusa: Hanegusa, Kanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Himegoge: Himegoke, Kurohimegoke, Hiodoshig, Hoshigusa Suginasugusa, Isobasho Genus: Isobasho, Fujimatsumo Genus: Fujimatsumo, Sawwort: Genus Hakezakinokawa, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome: Ideyugogome, Okitimozuku: Okitimozuku, Itogusa, Chinorimo: Chinorimo, Chisginori: Chisinori, etc.).

The axle algae (Charium spp.
Hossiturimo: Hossiturimo, Lichnotumnus, Flasks: Himegrass, Chabograss, Tripera etc., Yellow algae (Hikarimo: Hikarimo etc.) and the like.

Materials derived from animal-based raw materials include cockscomb extract, bovine, swine or human placenta extract, swine or bovine stomach, duodenum, intestine, spleen extract or its degradation product, bovine or swine. Extract of brain tissue, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate,
Elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof,
Silk protein and its degradation products or derivatives thereof, pig or bovine blood cell protein degradation products (globin peptide), cattle or pig hemoglobin degradation products (hemin, hematin, heme, protohem, heme iron, etc.), milk, casein and the like Decomposition products or their derivatives, skim milk powder and their decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid)
etc.

Materials derived from microbial materials include yeast metabolites, yeast extract extracts, bacterial metabolites, bacterial extract extracts,
Mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermented extract, rice bran (red bran, white bran) fermented extract, euglena extract or its decomposition product or water-soluble derivative thereof, Lactic acid fermentation products of raw milk or skim milk powder, trehalose or derivatives thereof.

As a material derived from a plant, animal, or microbial material, any site, cell, tissue, organ, metabolite, or the like derived from a recombinant or a cell fusion can be used. Furthermore, undifferentiated cells, cells undergoing differentiation, metabolites thereof, and the like, which are obtained by culturing cells at arbitrary sites, cells, tissues, organs, and the like, can also be used.

Examples of natural product raw materials include seawater such as deep seawater, for example, seawater salts, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud Or mud (Fango) s, for example, sea mud or mud in various places such as Italian Fango, German Fango, Eifelfango, Freiburg Fango, etc. (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, iron oxide, manganese oxide, sodium oxide, Marine components such as potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), and saintoku stone.

(14) Other components and additives that can be used in forming the form of a melanin production promoter or a cosmetic composition or bath composition: anhydrous silicic acid, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Inorganic pigments such as chromium hydroxide, carbon black, calamine, etc., hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxide tripolyphosphate, sodium bromate, bromine Potassium phosphate, sodium peroxide pyrophosphate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct,
Sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, thioglycolate) Redox agents such as sodium silicate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1- Amino-4-
Methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-hydrochloric acid
Diaminophenol, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol,
N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-
3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium piclaminate, N, N'-
Bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-Amino orthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene sulfate-
2,5-diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate , Catechol, diphenylamine, α
-Dyes such as naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein, musk, civet , Castorium, natural fragrances such as ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil,
Kananga essential oil, caraway essential oil, cardamom essential oil, guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger glass Essential oil, cedar essential oil, spearmint essential oil, western mint essential oil,
Great Fengxiang essential oil, tuberose essential oil, T-shaped essential oil, orange flower essential oil,
Winter green essential oil, true balsam essential oil, batchuri essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil, sandalwood essential oil, petitglen essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, peruvian balsam essential oil, boad rose essential oil, fragrance essential oil, mandarin Essential oil, eucalyptus essential oil, lime essential oil,
Plant flavors such as lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese mint essential oil, etc., other flavors such as synthetic flavors, red cabbage pigment, red rice pigment, Akane pigment, annatto pigment, cuttlefish pigment , Turmeric pigment, orange pigment, krill pigment, persimmon pigment, caramel, gold, silver, gardenia pigment, corn pigment, onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment,
Cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin and other pigments and coloring agents, avocado oil, almond oil, fennel oil, perilla oil, olive oil, Orange oil, orange raffinate oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukuinut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed oil, Persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, hydrogenated products of these oils (hardened oil, etc.), etc. Oils and fats, beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin,
Hard lanolin, candelilla wax, montan wax, shellac wax, waxes such as rice wax, squalene, squalane, pristane, liquid paraffin, vaseline, paraffin, ozokelide, ceresin, mineral oils such as microcrystalline wax, lauric acid, myristic acid, palmitic acid, Natural fatty acids such as stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid, and 2-ethylbutane Acids, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, fatty acids such as synthetic fatty acids such as isopentanoic acid, ethanol,
Isopyropanol, lauryl alcohol, cetanol,
Natural alcohols such as stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, and phenoxyethanol; alcohols such as synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol and 2-octyldodecanol; isopropyl myristate, isopropyl palmitate, and stearin Butylate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, monostearic acid Esters such as ethylene glycol, propylene glycol monostearate and propylene glycol dioleate, stearyl Metal soaps such as aluminum phosphate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, anionic surfactants (alkyl carboxylate, alkyl sulfonate) , Alkyl sulfate ester salts, alkyl phosphate ester salts), cationic surfactants (alkyl amine salts, alkyl quaternary ammonium salts), amphoteric surfactants: carboxylic acid type amphoteric surfactants (amino type, betaine type), sulfuric acid Ester-type amphoteric surfactants, sulfonic-acid-type amphoteric surfactants, phosphate-type amphoteric surfactants, nonionic surfactants (ether-type nonionic surfactants, ether-ester nonionic surfactants, ester-type nonionic surfactants) Ionic surfactant, block polymer type non-a Emissions surfactants, nitrogen-containing type nonionic surface active agents), other surfactants (natural surfactants, derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Surfactants such as fluorocarbon surfactants), and hair treatment agents such as selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, quinine hydrochloride, and strong ammonia water.

In addition, hormones, sequestering agents,
pH adjuster, chelating agent, antiseptic / antibiostatic agent, cooling agent, stabilizer, emulsifier, animal / vegetable protein and its decomposed product, animal / vegetable polysaccharide and its decomposed product, animal / vegetable glycoprotein and Decomposed products, anti-inflammatory and anti-allergic agents, wound treatment agents,
It is also possible to use a foaming agent, a thickening agent, an enzyme, purified water (electronic water, small clusters, etc.), a deodorant / deodorant, etc. in combination.

[0047]

The test examples and prescription examples of the present invention are shown below.
Although described more specifically, the present invention is not limited to these.

(Test Example 1) Melanin production promoting action test A medium containing 25 ppm of a component to be analyzed was added to B16 melanoma cells obtained in a 24-hour preculture (the same medium as that used in the preculture except for the component to be analyzed). Composition) and add 3
Incubate for days. Next, the cultured cells were treated with trypsin, and dissolved by heating with a 1N-NaOH, 10% DMSO solution, and then melanin produced in the melanoma cells was measured by absorbance at 475 nm. The components tested in this test were 2-hydroxybenzoylaminoacetic acid, 2-hydroxyphenylmethyl acetate, 2-hydroxymethylphenyl-β-D-glucopyranoside, sodium salicylate, and, as a control, ethanol and melanin production inhibitory effects. The test was performed with six types of arbutin. The melanin production-promoting action was represented by the ratio (%) of each component when the absorbance at 475 nm of ethanol as a target was 100.

(Results of Test Example 1) FIG. 1 shows the melanin production promoting action of each component. 150.54% for 2-hydroxybenzoylaminoacetic acid compared to the target ethanol,
166.13 for 2-hydroxyphenylmethyl acetate
%, 2-hydroxymethylphenyl-β-D-glucopyranoside 192.47%, sodium salicylate 145.70%
And a very high melanin production promoting action.

(Test Example 2) Skin browning test 2-hydroxybenzoylaminoacetic acid or 2-hydroxymethylphenyl-β-D-glucopyranoside 0.1% by weight, allantoin 0.1% by weight, hyaluronic acid 0.5% by weight, polyoxyethylene oleyl alcohol 1.0% by weight, glycerin
3.0% by weight, 0.05% by weight of citric acid and the remaining amount of purified water were mixed to prepare a skin external preparation. As an object, a skin external preparation having the same composition in which salicylic acids or salicyl alcohols were replaced with ethanol was prepared. Each of the prepared skin external preparations was applied once a day to the upper arm of 10 women, and continued for 1 week so that the application site was not exposed to light. 2-hydroxybenzoylaminoacetic acid and 2-hydroxymethylphenyl-β-D -The effects of glucopyranoside on skin browning and at the same time on skin quality were examined. The browning is measured using a color difference meter (CR-200: manufactured by Minolta Co., Ltd.)
Value). As the amount of melanin in the skin increases,
Lightness (L value) decreases. The effect on the skin quality can be measured by applying the external preparation to the skin in the subject [skin roughness] and [skin elasticity]
The number of people who could feel the improvement was investigated.

[0051]

[Table 1] Skin browning test

(Results of Test Example 2) The results of examining the effects of 2-hydroxybenzoylaminoacetic acid and 2-hydroxymethylphenyl-β-D-glucopyranoside on skin browning are shown in Table 1. The lightness (L value) was the average of the measured values of 10 persons. [Skin roughness] and [Skin elasticity] indicate the number of subjects in which these items were improved. The lightness of the target ethanol was 68.3, whereas that of 2-hydroxybenzoylaminoacetic acid was 57.2, and that of 2-hydroxymethylphenyl-β-D-glucopyranoside was 53.
6, indicating a clear skin browning, indicating that it has an excellent melanin production promoting action. Furthermore, it was shown that the effects of the combined components, i.e., skin roughness improving effect and skin elasticity improving effect, were sufficiently exhibited.

(Test Example 3) Hair blackening test 2-hydroxybenzoylaminoacetic acid or 2-hydroxymethylphenyl-β-D-glucopyranoside 0.1% by weight, ethanol 25.0% by weight, polyoxypropylene butyl ether phosphoric acid 10.0% by weight, poly 5.0% by weight of oxypropylene monobutyl ether, 3.0% by weight of carboxymethyl chitin, 0.2% by weight of tocopherol, and the remaining amount of purified water were mixed to prepare a hair liquid. Each of the prepared hair liquids was applied to the head of five men once a day for 4 weeks, and the hair was blackened by 2-hydroxybenzoylaminoacetic acid and 2-hydroxymethylphenyl-β-D-glucopyranoside. And the effect on hair quality at the same time. The blackening was measured using a colorimeter (CR-200: manufactured by Minolta Co., Ltd.), and the calculated lightness (L value) was examined. As the amount of melanin in the hair increases, the lightness (L
Value) decreases. The influence on the hair quality was examined by examining the number of test subjects who felt the improvement of [Pasatsu] and [Hair loss] by applying hair liquid.

[0054]

[Table 2] Hair blackening test

(Results of Test Example 3) The results of examining the effects of 2-hydroxybenzoylaminoacetic acid and 2-hydroxymethylphenyl-β-D-glucopyranoside on the blackening of hair are shown in Table 2. The lightness (L value) was an average value of the measured values of five persons. [Pasatsuki] and [Hair loss] indicate the number of test subjects who improved these items.
In the hair liquid containing 2-hydroxybenzoylaminoacetic acid, the hair whose lightness before the test was 24.6 decreased to 18.5 after the test, and also contained 2-hydroxymethylphenyl-β-D-glucopyranoside. In the hair liquid, the hair whose brightness before the test was 23.2 changed to 17.9 after the test.
It was clearly shown that the compound had an effect of increasing the amount of melanin in hair and promoting blackening. Furthermore,
It was shown that the effect of the combination component, ie, the effect of preventing or improving pastsuki and hair loss, etc., was sufficiently exhibited.

(Formulation example) Production of melanin production promoter or cosmetic composition According to the above evaluation results, the formulation examples are shown below. , Only the blending amount is shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 5.0 2. Olive oil 5.0 3. Jojoba oil 5.0 4. Cetyl alcohol 1.5 5. Glycerin monostearate 2.0 6. Polyoxyethylene (20) cetyl ether 3.0 7. Poly Oxyethylene (20) soorbitan monooleate 2.0 8.1,3-butylene glycol 1.0 9. Glycerin 2.0 10.2-Hydroxybenzoylaminoacetic acid 0.1 11. Preservative (paraoxybenzoate) qs 12. Purified water 100

(Formulation Example 2) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Glyceryl paraaminobenzoate 1.0 4. Ethyl urocanate 1.0 5. Magnesium salt of vitamin C phosphate ester 1.0 6. Cetyl alcohol 1.5 7. Glycerin monostearate 2.0 8. Polyoxyethylene (20) cetyl ether 3.0 9. Polyoxyethylene (20) soorbitan monooleate 2.0 10.1,3-butylene glycol 1.0 11. Glycerin 2.0 12. Fermented milk extract 1.0 13.2-hydroxy Methylphenyl-β-D-glucopyranoside 0.1 14. Preservative (para-hydroxybenzoate) qs 15. Residual to 100 purified water

(Formulation Example 3) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Grapefruit fruit or leaf hot water extract 3.0 6. Rice bran hot water extract 1.0 7. Olive oil 1.0 8. Shea butter 1.0 9. Sodium salicylate 0.2 10. Butylhydroxyanisole 0.1 11. Vitamin E derivative 0.1 12. Preservative (benzalkonium chloride) proper amount 13. Fragrance (chamomile water) proper amount 14. Purified water 100 and the rest

(Formulation Example 4) Lotion by weight 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Grapefruit fruit or leaf hot water extraction Liquid 1.0 6. Horse chestnut whole plant 50% ethanol extract 1.0 7. Kiwi fruit 50% ethanol extract 1.0 8.2-Hydroxymethylphenyl-β-D-glucopyranoside 0.1 9. Resorcin 0.1 0.1 Antibacterial and preservative (lactoferrin solution) Appropriate amount 11.Fragrance (Western thin water) Appropriate amount 12.Purified water 100 residue

(Formulation Example 5) Lotion by weight 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 4. Gentian whole plant 50% ethanol extract 1.0 5. Hamamelis leaf or bark 50% ethanol extraction Liquid 1.0 6. Allantoin 0.2 7. Astringent (zinc sulfocarbonate) 0.2 8.2-2-Hydroxybenzoylaminoacetic acid 0.2 9. Antibacterial and preservative (thiamine lauryl sulfate) qs 10. Fragrance (lavender water) qs 11. Purified water 100 and the rest

(Formulation Example 6) Two-layer type lotion (liquid to liquid type)% by weight 1. Squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. Sorbit 1.0 4. Ethanol 15.0 5. Purple Root 50 % Propylene glycol extract 2.0 6. Chestnut fruit 30% ethanol extract 1.0 7. Ascorbic acid 0.2 8.2-Hydroxyphenylmethyl acetate 0.1 9. Astringent (calamine) 0.1 10. Dipotassium glycyrrhizinate 0.1 11. Preservative (phenoxyethanol) Appropriate amount 12.Perfume (lemon water) Appropriate amount 13.Purified water 100 residue

Formulation Example 7 Carmine Lotion (Liquid to Solid) Weight% 1. Glycerin 3.0 2.1,3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Hyaluronic acid 3.0 7.Kaolin 2.0 8.Shiso leaf 50% propylene glycol extract 2.0 9.Western linden tree flower or leaf 50% propylene glycol extract 1.0 10.Green tea leaf or stem 50% 1,3-butylene glycol extract 1.0 11.Camphor 0.2 12.2-Hydroxybenzoylaminoacetic acid 0.2 13.Phenol 0.03 14.Preservative (Photosensitizer 201 & 401) Appropriate amount 15.Fragrance (Iran-ylang water) Appropriate amount 16.Purified water 100 residue

(Formulation Example 8) Pack weight% 1. Polyvinyl alcohol 15.0 2. Carboxymethyl cellulose sodium 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Panax ginseng rhizome 30% ethanol extract 1.0 6. Rhododendron rhizome or root bark 50% Propylene glycol extract 1.0 7.2-Hydroxymethylphenyl-β-D-glucopyranoside 0.1 8. Yeast extract 0.1 9. Preservative (parahydroxybenzoate) qs 10. Fragrance (rose water) qs 11. Purified water 100

(Formulation Example 9) Peel-off pack weight% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Assembly whole plant 50 % Ethanol extract 1.0 8. Spiraea flower 50% propylene glycol extract 1.0 9. Urea 0.3 10. 2-Hydroxymethylphenyl-β-D-glucopyranoside 0.1 11. Preservative (para-hydroxybenzoate) qs 12. Fragrance (Hiba leaf water) Appropriate amount 13.Purified water 100 residue

(Formulation Example 10) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 5.0 5. Chamomile oil 5.0 6. Palm oil 5.0 7. Borax 0.5 8. Parietaria leaf extraction Liquid 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 9.Dokudami leaf extract 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 10.Birch bark extract 2.0 (Ethanol : 1,3-butylene glycol = 1: 1 extraction solvent) 11.Liquid shea fat 1.0 12.2-Hydroxybenzoylaminoacetic acid 0.2 13.Preservative (acrinol) 0.1 14.Perfume (Bodhi tree water) Suitable amount 15.Purified water 100 Residue

(Formulation Example 11) Emollient cream weight% 1. stearic acid 2.0 2. stearyl alcohol 7.0 3. reduced lanolin 2.0 4. squalane 5.0 5. octyldodecanol 6.0 6. polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Shakuyane root 50% propylene glycol extract 1.0 10. Chamomile flower 50% propylene glycol extract 1.0 11. Sodium salicylate 0.3 12. Calcium pantothenate 0.2 13. Preservative (paraben) proper amount 14.Fragrance (cinch water) proper amount 15.Purified water 100 residue

(Formulation Example 12) Face Wash Cream% by Weight 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Rosemary Leaf or flower hot water extract 2.0 8. Loofah peel or fruit powder 2.0 9. Dipotassium glycyrrhetinate 1.0 10. 2-Hydroxymethylphenyl-β-D-glucopyranoside 0.2 11. Preservative (phenoxyethanol) 0.1 12. Fragrance (bergamot water) Appropriate amount 13.Purified water 100 residue

(Formulation Example 13) Face wash cream% by weight 1. Stearic acid 10.0 2. Palmitic acid 10.0 3. Myristic acid 12.0 4. Lauric acid 4.0 5. Oleyl alcohol 1.5 6. Lanolin derivative (EO adduct) 1.0 7. Glycerin 18.0 8. Potassium hydroxide 6.0 9. Carboxymethyl chitin 3.0 10. Royal jelly extract 1.0 (Ethanol: 1,3-butylene glycol = 1: 1 extract) 11. Glycyrrhetinic acid 1.0 12. 2-Hydroxybenzoylaminoacetic acid 0.2 13. Preservative (1,2-Pentanediol) 0.1 14.Perfume (Mugwort water) Appropriate amount 15.Purified water 100 residue

(Formulation Example 14) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. 70% Himematsutake 1,3-butylene glycol extract 1.0 5. 70% wakame 1, 3-butylene glycol extract 0.5 6. Melyloth flower or leaf 70% 1,3-butylene glycol extract 0.5 7. Amacail leaf or stem 70% 1,3-butylene glycol extract 0.5 8. Usvenia oil flower or leaf 50% propylene Glycol extract 2.0 9. Polyethylene powder 0.5 10. Hydroxypropyl chitosan solution 0.5 11. Glutamic acid 0.5 12. 2-Hydroxyphenylmethyl acetate 0.1 0.1 Preservative (undecylenic acid, phenol) qs 14. pH adjuster qs 15. Perfume (lavender) Water) Appropriate amount 16. Residual water to make purified water 100

(Formulation Example 15) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7.glyceryl monostearate 2.0 8.polyethyl acrylate 1.0 9.1,3-butylene glycol 6.0 10.disodium edetate 0.1 11.triethanolamine 1.0 12.titanium dioxide 5.0 13.2-hydroxybenzoylaminoacetic acid 0.3 14.cornflower 50 % Dipropylene glycol extract 0.5 15. Kakkon 50% dipropylene glycol extract 0.5 16. Cholecalciferol 0.2 17. Preservative (paraben) qs 18. Fragrance (apple water) qs 19. Purified water 100

(Formulation Example 16) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5.2-Hydroxymethylphenyl-β- D-glucopyranoside 0.1 6. Burdock root 50% 1,3-butylene glycol extract 0.5 7. Adlay whole plant 50% 1,3-butylene glycol extract 0.5 8. Peach fruit 30% 1,3-butylene glycol extract 2.0 9. Suitable amount of antioxidant (butylhydroxytoluene) 10. Suitable amount of fragrance (cornflower water)

(Formulation Example 17) Cream foundation (O / W type) weight% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Sodium montmorillonite 1.0 10. Titanium oxide 8.0 11.2,4-Dihydroxybenzophenone 8.0 12. Kaolin 3.0 13. Talc 3.0 14. Color pigment (iron iron oxide) 1.0 15.2-Hydroxybenzoyl Aminoacetic acid 0.2 16. Toxin flower 50% 1,2-butylene glycol extract 0.5 17. Preservative (phenoxyethanol) qs 18. Fragrance (rose water) qs 19. Purified water 100

(Formulation Example 18) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6.2-Hydroxymethylphenyl-β-D-glucopyranoside 0.2 7. Keratin hydrolyzate 0.5 8. Panax ginseng root 50% ethanol extract 1.0 9. Toki root 30% 1,4-butylene glycol extract 1.0 10. Hydroxypropyl chitosan Solution 2.0 11. Mucopolysaccharide solution 1.0 12. Antibacterial and preservative (photosensitizer No. 101) proper amount 13. pH adjuster proper amount 14. Fragrance (sandalwood water) proper amount 15. Purified water 100 residue

(Formulation Example 19) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5.2-Hydroxybenzoylaminoacetic acid 0.1 6. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0 7. Coltsfoot flower or leaf 50% 1,3-butylene glycol extract 1.0 8. Hydroxyethyl chitosan solution 1.0 9. Trehalose solution 1.0 10. Hydrolyzed silk solution 1.0 11 .Antimicrobial and preservative (benzalkonium chloride) qs 12. flavor (lavender water) qs 13. purified water 100

(Formulation Example 20) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Ethylene glycol 3.0 6.2-Hydroxyphenylmethyl acetate 0.2 7. Loquat leaf 30% ethanol extract 1.0 8. Safflower whole plant 50% ethanol extract 1.0 9. Dutch jelly (parsley) leaf or stem 50% ethanol extract 1.0 10. Trehalose solution 1.0 11. Hydrolyzed keratin solution 1.0 12. Antibacterial and preservative (benzalkonium chloride) proper amount 13. Fragrance (chamomile water) proper amount 14. Purified water 100 residue

(Formulation Example 21) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5.2-Hydroxybenzoylaminoacetic acid 0.2 6. Hop female Flower ear 50% ethanol extract 1.0 7. Carpronium chloride 0.3 8. Hinokitiol 0.5 9. Keratin decomposition solution 1.0 10. Antibacterial and preservative (paraben, benzalkonium chloride) qs 11. perfume (rosehip water) qs 12. purified water 100 and the rest

(Formulation Example 22) Hair liquid weight% 1. ethanol 29.0 2. polyoxypropylene butyl ether phosphoric acid 10.0 3. polyoxypropylene monobutyl ether 5.0 4. triethanolamine 1.0 5. trimethylene glycol 5.0 6.2-hydroxymethylphenyl -β-D-glucopyranoside 0.2 7. Lemon fruit 50% 1,3-butylene glycol extract 0.5 8. Apple fruit 30% ethanol extract 1.0 9. Camphor 0.1 10. Azulene 1.0 11. Antibacterial and preservative (paraben, chloride) Benzalkonium) Appropriate amount 12. Fragrance (jasmine water) Appropriate amount 13. Purified water 100

(Formulation Example 23) Hair tonic% by weight 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4.2-Hydroxymethylphenyl-β-D-glucopyranoside 0.2 5. Chondroitin sulfate 1.0 6. 50% ethanol extract of comfrey leaves or stem 3.0 7. 50% ethanol extract of lettuce leaves 3.0 8. Preservative (phenoxyethanol) 0.1 9. Residue with purified water 100

(Formulation Example 24) Hair tonic weight% 1. l-menthol 0.2 2. ethanol 32.5 3. polyoxyethylene hydrogenated castor oil 0.5 4. propylene glycol 5.0 5. diphenhydramine hydrochloride 0.3 6. sodium salicylate 0.2 7. pepper fruit Hot water extract 1.0 8. Beetle rhizome or root bark 50% ethanol extract 1.0 9. Japanese gourd rhizome or root bark 50% ethanol extract 1.0 10. Guillaium rhizome or root bark 50% ethanol extract 1.0 11. Sodium polyglutamate Salt 1.0 12. Vitamin E derivative 0.5 13. Antibacterial and preservative (paraben) 0.1 14. Appropriate amount of fragrance (sage water) 15. Purified water 100 residue

(Formulation Example 25) Hair restorer / hair restorer% by weight 1. Ethanol 60.0 2.2-Hydroxybenzoylaminoacetic acid 0.5 3. Biloba oil rhizome or root bark 50% ethanol extract 1.0 4. Tachisou whole plant 50% propylene glycol extract 2.0 5. Vitamin E derivative 0.5 6. Pepper tincture 0.5 7. Resorcinol 0.5 8. Dipotassium glycyrrhizinate 0.5 9. Carboxymethyl chitin solution 0.5 10. Porcine hematin solution 0.5 11. Porcine mucin solution 0.5 12. Amino acids (glycine, glutamine, etc.) 0.5 13. Antibacterial and preservative (paraben) 0.1 14. Appropriate amount of fragrance (rosemary water) 15. Residual with purified water 100

(Formulation Example 26) Hair restorer / hair restorer% by weight 1. Ethanol 60.0 2.2-Hydroxymethylphenyl-β-D-glucopyranoside 0.5 3. Ethanol extract of whole plant 60% 1.0 4. Button rhizome or root bark 60% ethanol Extract solution 1.0 5. Cantaristin tincture 0.5 6. Pantothenic acid derivative 0.5 7. Glycyrrhizic acid 0.5 8. Resorcinol 0.5 9. Carpronium chloride 0.5 10. Hydroxyethyl chitosan solution 0.5 11. Elastin hydrolyzate 0.5 12. Antibacterial and preservative ( Paraben) 0.1 13.Perfume (lavender water) Appropriate amount 14.Purified water 100 residue

(Formulation Example 27) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 2.0 4.2-Hydroxymethylphenyl-β-D-glucopyranoside 0.5 5. Drying of hot water extract from Sengoku Powder 8.0 6. Jujube whole plant hot water extract dry powder 2.0 7. Satsuma mandarin 50% ethanol extract dry powder 1.0 8. Dye (Gunjo green) Appropriate amount

(Formulation Example 28) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 4.0 4.2-Hydroxybenzoylaminoacetic acid 0.5 5. Black tea hot water extract dry powder 1.0 6. Iris Leaf or root 70% ethanol extract dry powder 1.0 7. Apple juice powder 1.0 8. Dye (Gunjo, chromium hydroxide) qs 9. Fragrance (Roman chamomile water) qs

(Formulation Example 29) Coating protective agent 2-hydroxymethylphenyl on gauze or liniment cloth
-Impregnated with a prescription solution containing an appropriate amount of β-D-glucopyranoside, antibiotics, anti-inflammatory agent, etc., and attach it to the wound. or,
Production Example 1 may be directly applied locally and covered with gauze or the like.

[0086]

According to the present invention, at least one or more selected from the salicylic acid of the present invention or a derivative thereof, or a salt thereof, and / or
Or a melanin production promoter or a cosmetic composition containing at least one selected from salicyl alcohol or a derivative thereof as an active ingredient is excellent in melanin production promotion action, increases the amount of melanin in skin and hair, and is caused by ultraviolet rays and the like. The appearance can be excellent in browning of the skin and blackening of the hair without causing various skin disorders. Furthermore, since the efficacy of other active ingredients used in combination is not inhibited, it is possible to promote the production of melanin and, at the same time, sufficiently express the efficacy of the active ingredients that bring about improvement of various skin and hair conditions, It is possible to provide a more preferable cosmetic composition in terms of properties.

[Brief description of the drawings]

FIG. 1. B16 of salicylic acids and salicyl alcohols
It is a figure showing the melanin production promotion action in melanoma cells.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 7/08 A61K 7/08 7/11 7/11 7/44 7/44 7/48 7/48 7 / 50 7/50 31/60 31/60 31/609 31/609 31/7034 31/7034 A61P 17/14 A61P 17/14 17/16 17/16 F term (reference) 4C083 AA032 AA072 AA082 AA112 AA122 AB032 AB172 AB212 AB232 AB242 AB272 AB312 AB352 AB432 AB442 AC022 AC032 AC072 AC102 AC122 AC132 AC172 AC182 AC212 AC242 AC342 AC352 AC422 AC432 AC442 AC471 AC472 AC532 AC542 AC552 AC582 AC641 AC642 AC682 AC692 AC782 AC792 AC852 AC902 AD022 AD072 AD112 AD322 AD332 AD112 AD412 AD332 AD512 AD532 AD552 AD642 AD652 AD662 CC04 CC05 CC06 CC07 CC12 CC19 CC23 CC25 CC32 CC33 CC37 CC38 CC39 DD05 DD12 DD23 DD27 DD30 DD31 DD33 EE03 EE17 EE22 4C086 AA01 AA02 DA17 EA08 MA02 MA04 MA63 NA05 ZA89 ZA9 2 4C206 AA01 AA02 DB22 DB43 MA02 MA04 MA83 NA05 ZA89 ZA92

Claims (3)

[Claims] 1. A salicylic acid represented by the general formula I or a derivative thereof, or at least one compound selected from salts thereof, and / or at least one selected from a salicylic alcohol represented by the general formula II or a derivative thereof. A melanin production promoter comprising the above compound as an active ingredient. [Formula 1] [R ₁ in the general formula is a compound having a carboxyl group (—COOH) or a compound having an ester group with a compound having a hydroxyl group (—OH), or a compound having an amino group (—NH ₂ ) and an amide It is a carboxyl group forming a bond. R ₂ is a hydroxyl group, or a hydroxyl group forming an ester bond with a compound having a carboxyl group,
Or a hydroxyl group forming an ether bond with a compound having a hydroxyl group. [Formula 2] [R ₃ in the general formula is a compound having an ester bond with a compound having a hydroxymethyl group (—CH ₂ OH) or a carboxyl group, or an ether bond with a compound having a hydroxyl group. Is a hydroxymethyl group. R ₄ is a hydroxyl group (—OH), a hydroxyl group forming an ester bond with a compound having a carboxyl group, or a hydroxyl group forming an ether bond with a compound having a hydroxyl group. ] 2. The method according to claim 1, wherein the salicylic acid or its derivative represented by the general formula I or its salt is 2-hydroxybenzoylaminoacetic acid or sodium salicylate, and / or the salicylic alcohol or its derivative represented by the general formula II is 2-hydroxybenzoylaminoacetic acid or its derivative.
The melanin production promoter according to claim 1, which is hydroxy-phenylmethyl acetate or 2-hydroxymethyl-phenyl-β-D-glucopyranoside. 3. A salicylic acid represented by the general formula I or a derivative thereof, or at least one compound selected from a salt thereof, and / or at least one selected from a salicylic alcohol represented by the general formula II or a derivative thereof. A cosmetic composition comprising the melanin production promoter according to claim 1 or 2, comprising the above compound as an active ingredient.