JP2002068924A - Antimicrobial agent composition for cosmetic and cosmetic containing the same formulated therewith - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an antimicrobial agent composition for a cosmetic, having excellent antimicrobial activities even in an alkaline region, and further having high safety, and further to provide the cosmetic containing the composition formulated therewith. SOLUTION: This antimicrobial composition for the cosmetic is characterized in that the composition contains at least one kind of parabens and a water-soluble component obtained by fractionating water-insoluble components from an extract obtained by extracting clove with an organic solvent, or the like, and deodorizing and purifying the resultant product, in combination with a monoglyceride of an 8-12C fatty acid. The cosmetic having excellent antimicrobial activities even in the alkaline region can be obtained by formulating the antimicrobial agent composition for the cosmetic.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an antibacterial cosmetic composition and a cosmetic, and more particularly to a cosmetic having excellent antibacterial properties even in an alkaline region.

[0002]

2. Description of the Related Art Conventionally, cosmetics and quasi-drugs have been used as preservatives and bactericides such as parabens such as methylparaben, ethylparaben, propylparaben and butylparaben, benzoic acid and its salts, salicylic acid and its salts, dehydroacetic acid and its derivatives. Salt and the like are used, and paraben is most widely used.

[0003] However, it is known that antibacterial properties of parabens decrease in an alkaline region. For example, John J. Kabbalah's "Science of Cosmetics, Pharmaceuticals, Preservatives and Disinfectants" (Fragrance Journal) states that molecules of parabens are dissociated when the pH rises to 8 or more, and the pH 8.
In No. 5, it is described that a considerable loss of antibacterial activity occurs because 50% of them are dissociated. Also J.Soc.Cosme
t. Chem. , 38, 83-98 (1987) states that methyl paraben
It is described that when it is 8.3 or more, phenolic hydroxyl groups are dissociated, and as a result, the antibacterial activity of a cosmetic containing a dye or a pigment is reduced. Thus, parabens have excellent antibacterial properties in cosmetics in the acidic to neutral range, but their antibacterial properties are not always satisfactory in the alkaline range.

[0004] In addition, if a large amount of parabens is added in consideration of these reductions in antibacterial properties, antibacterial properties can be maintained even in cosmetics in the alkaline range, but in recent years, skin irritation of parabens has become a problem. Therefore, from the viewpoint of safety, it is desired to use a compounding amount as small as possible.

[0005] In general, many basic cosmetics such as lotions and creams are weakly acidic. However, cosmetics prepared to be weakly alkaline for the purpose of maintaining the stability of drug components, cosmetics when soap is used as an emulsifier, In the case of detergents containing soap as a main component, cosmetics in the alkaline region are often found.

[0006]

Therefore, if a cosmetic having excellent antibacterial properties even in an alkaline region and excellent in safety and usability can be provided, its significance will be extremely large. SUMMARY OF THE INVENTION An object of the present invention is to provide a cosmetic that can sufficiently prevent quality deterioration by microorganisms while solving the problems of conventional cosmetics in the alkaline region.

[0007]

Means for Solving the Problems As a result of intensive studies, the present inventors have found that at least one of parabens and
Extracted from the clove using an organic solvent, etc., water was added to the extract to remove precipitated water-insoluble components, and water-soluble components obtained by removing essential oil components by distilling off water,
It has been found that, by combining with a fatty acid monoglyceride having 8 to 12 carbon atoms, the composition exhibits excellent antibacterial properties against a wide range of microorganisms even in an alkaline region, and has completed the present invention.

Hereinafter, the present invention will be described in detail. The parabens used in the present invention include, in particular, methyl paraben, ethyl paraben, propyl paraben and butyl paraben.
These are seeds, which have been widely used as antiseptic and disinfecting agents for cosmetics. In the present invention, one or more of the above-mentioned four types of parabens are used, and the blending amount thereof is preferably 0.01 to 1% by weight, particularly preferably 0.05 to 0.2% by weight. A blending amount of 0.2% by weight or more is not so preferable from the viewpoint of skin irritation.

The clove used in the present invention is a clove ( eugenia caryophyllat) , a plant belonging to the family Myrtaceae.
a ) Flower buds, leaves, stems and the like are mentioned, and flower buds are particularly preferred. The water-soluble component of the clove in the present invention is obtained by extracting the clove with an organic solvent or the like, removing water-insoluble components precipitated by adding water to the obtained extract, and removing essential oil components while distilling off water. It can be obtained by: The amount of the water-soluble component obtained from this clove is preferably 0.001 to 1% by weight, particularly preferably 0.002 to 0.5% by weight.

The fatty acid monoglycerides having 8 to 12 carbon atoms used in the present invention include monoglycerides such as caprylic acid, pelargonic acid, capric acid, undecylic acid and lauric acid. Diglycerides and triglycerides also have some antibacterial effects, but monoglycerides are the most effective. Fatty acid monoglycerides having 7 or less carbon atoms or having more than 13 carbon atoms also have an effect, but are practically limited to fatty acid monoglycerides having 8 to 12 carbon atoms in terms of odor and solubility. The amount of these components is preferably 0.01 to 1% by weight, particularly preferably 0.05 to 0.5% by weight.

By combining parabens with the water-soluble component obtained from the above cloves and fatty acid monoglyceride, excellent antibacterial properties can be obtained even in an alkaline region with a small amount of use without increasing the amount of parabens. Can be demonstrated.

Further, other antiseptic and fungicides other than parabens can be used in combination with the above antibacterial agent composition as long as they do not affect skin irritation, safety and usability. Examples of such preservatives include phenols such as isopropylmethylphenol, hinokitiol, and phenoxyethanol; benzoic acid and its salts; salicylic acid and its salts; dehydroacetic acid and its salts; sorbic acid and its salts; and acids such as benzalkonium chloride. And quaternary ammoniums such as benzethonium chloride and alkyltrimethylammonium chloride; amphoteric activators such as alkylaminoethylglycine hydrochloride and sodium stearylhydroxyethylbetaine chloride; and photosensitizers.

The cosmetics of the present invention include basic cosmetics such as creams, milky lotions, lotions, and essences; cleaning cosmetics such as soaps, facial cleansers, shampoos, and rinses; hair cosmetics such as hair tonics and hair styling products; , Eyeliner, mascara, lipstick, etc., cosmetics such as toothpaste, bath cosmetics, etc.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples.

[Preparation Example] Extraction of water-soluble components from cloves 150 g of dried flower buds of clove were added with 300 g of 80% aqueous ethanol, extracted at normal temperature for 24 hours, and filtered to obtain an extract under reduced pressure. When 600 g of water was added to the extract, a water-insoluble component was precipitated. Centrifuge this solution (10,000 rp)
(10 minutes), the precipitate was separated, and the supernatant was collected and concentrated under reduced pressure to 300 g. Further, 600 g of water was added to this concentrated solution, and the mixture was concentrated under reduced pressure until the concentration became 300 g, thereby obtaining a clove extract containing only a water-soluble component.

[Method for evaluating antibacterial activity] The following test strains A to E were used. A: Staphylococcus aureus ATCC 653
8) B: Escherichia coli ATCC 8739 C: Pseudomonas aeruginosa ATCC 9627 D: Candida albicans ATCC 10231 E: Asperugillus niger ATCC 16404 Bacteria (A) per 1 g of sample To C) were inoculated with 10 ⁶ fungi and the fungi (D and E) were inoculated with 10 ⁵ and cultured at 37 ° C. and 25 ° C., respectively.
The viable cell count was measured on the 1st and 28th days, and the antibacterial property was evaluated based on the following criteria.

[Evaluation Criteria for Antibacterial Activity] In the case of a bacterial sample: the inoculated bacteria decrease to 0.1% or less of the initial number of bacteria within 14 days, and maintain the level before that in the remaining 14 days, or It decreases below that. For fungal samples: the inoculated fungus decreases to less than 10% of the initial number of bacteria within 14 days and maintains or decreases to the previous level in the remaining 14 days. The test results are shown as "○" for those that passed and "X" for those that failed.
Displayed as

[Examples and Comparative Examples 1 to 4] Each component of <1> to <10> was mixed to prepare a lotion having the composition shown in Table 1. The blending amount was% by weight, and the total composition was 100% by weight. Also, the evaluation method described above,
Each antibacterial property was evaluated based on the evaluation criteria.

[0019]

[Table 1]

From the results shown in Table 1, in Examples in which methylparaben, clove extract and glycerin monocaprylate were used in combination, good antibacterial properties were exhibited against all the test strains with a small amount of methylparaben. On the other hand, in Comparative Example 1 in which only methylparaben was blended, the criterion was rejected for gram-positive bacteria S. aureus and Candida yeast. In Comparative Example 2 using only clove extract and glycerin monocaprylate, Comparative Example 3 using only methylparaben and clove extract against Pseudomonas aeruginosa and Escherichia coli, which are gram-negative bacteria.
In Comparative Example 4, in which only methylparaben and glycerin monocaprylate were used in combination for Candida yeast, the criterion was rejected for Staphylococcus aureus.

[0021]

According to the cosmetic of the present invention, at least one kind of parabens, a water-soluble component extracted from clove, and a monoglyceride having 8 to 12 carbon atoms are combined and blended to reduce the amount of parabens. The amount of the compound eliminates problems such as skin irritation and has good antibacterial properties even in cosmetics in the alkaline region.

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Claims (2)

[Claims] 1. A water-soluble component obtained by separating at least one of parabens and a water-insoluble component from an extract obtained by extracting a clove with an organic solvent or the like, followed by deodorization and purification. 0.001 to 1% by weight and a fatty acid monoglyceride having 8 to 12 carbon atoms in a combination of 0.01 to 1% by weight. 2. A composition comprising the antibacterial agent composition according to claim 1 and
H is 7-12, The cosmetics characterized by the above-mentioned.