JP2001322921A - Liquid oral composition - Google Patents

Abstract

(57) Abstract: A composition comprising a cationic germicide, capsaicin, a nonionic surfactant, and l-menthol, wherein the cationic germicide is used in an amount of 0.02 to 0.1% by mass when used. A composition for liquid oral use, wherein capsaicin is blended at a ratio of 0.1 to 4 ppm at the time of use. According to the present invention, a highly palatable liquid oral composition having a refreshing sensation, a refreshing sensation and the like can be obtained without deactivating the cationic germicide.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid oral composition containing a cationic bactericide and a perfume containing l-menthol.

[0002]

2. Description of the Related Art Most liquid oral compositions are added with a fragrance component for the purpose of imparting palatability such as refreshing sensation and refreshing sensation. Since it is an oil-soluble substance, it is necessary to solubilize it with a surfactant in order to stably incorporate an amount of a fragrance component capable of providing a sufficient refreshing feeling into a liquid oral composition, and many commercially available liquid oral compositions are used. The composition for use contains a nonionic surfactant to solubilize the perfume component.

On the other hand, various oral compositions containing a cationic germicide such as benzethonium chloride and cetylpyridinium chloride which are effective in inhibiting plaque formation have been proposed. There is a problem that it is solubilized and deactivated in micelles formed by a nonionic surfactant in a liquid oral composition such as a liquid oral cavity composition. It is necessary to reduce the amount of ionic surfactant.

[0004] Therefore, without inactivating the cationic germicide,
Further, there has been a demand for development of a liquid oral composition that can impart palatability such as sufficient refreshing feeling and refreshing feeling.

[0005] The present invention has been made in view of the above circumstances,
An object of the present invention is to provide a composition for a liquid oral cavity that can impart palatability such as sufficient refreshing feeling and refreshing feeling without impairing the bactericidal action of a cationic germicide.

[0006]

Means for Solving the Problems and Embodiments of the Invention The present inventors have made intensive studies in order to achieve the above object, and as a result, have found that they contain a cationic bactericide, a nonionic surfactant and l-menthol. In a liquid oral cavity composition containing a fragrance, a cationic fungicide is used in an amount of 0.02 to 0.1% when used.
(% By mass, the same applies hereinafter) and at the same time capsaicin is used at a ratio of 0.1 to 4 ppm when used. In this case, preferably, a nonionic surfactant is used at 0.02 to 0 ppm when used. By mixing at a ratio of .14%, a sufficient bactericidal effect can be obtained without deactivating the cationic bactericide, and by adding a specific amount of capsaicin, the refreshing feeling and refreshing feeling of l-menthol are enhanced. Thus, the present inventors have found that a liquid oral composition having a high palatability can be obtained, and have accomplished the present invention.

Hereinafter, the present invention will be described in more detail. The liquid oral composition of the present invention is prepared as a liquid dentifrice, mouthwash, mouthwash, etc., and includes a cationic disinfectant, capsaicin, nonionic Contains a surfactant, l-menthol.

The cationic fungicides include alkylpyridinium salts, mono-long-chain alkyltri-short-chain alkylammonium salts, mono-long-chain alkyldi-short-chain alkylbenzylammonium salts, and alkylphenylethoxyethyldi-short-chain alkylbenzylammonium salts. And the like. Examples of the alkylpyridinium salt include laurylpyridinium salt, myristylpyridinium salt, and cetylpyridinium salt.Examples of the mono-long-chain alkyltri-short-chain alkylammonium salt include lauryltrimethylammonium salt, myristyltrimethylammonium salt,
Cetyltrimethylammonium salt, stearyltrimethylammonium salt and the like. Examples of the mono-long-chain alkyldi-short-chain alkylbenzylammonium salt include lauryldimethylbenzylammonium salt, myristyldimethylbenzylammonium salt (benzalkonium salt), and cetyldimethylbenzylammonium salt. , Stearyldimethylbenzylammonium salt and the like, and the alkylphenylethoxyethyldi-short-chain alkylbenzylammonium salt includes a benzethonium salt, and the form of these salts includes chloride, bromide and iodide. These cationic fungicides may be used alone or as a mixture of two or more. As the compounding amount of these cationic germicides, the concentration at the time of use is 0.02 to 0.1%, and if it is less than 0.02%, a sufficient bactericidal effect cannot be obtained,
If the amount is more than 0.1%, the bitterness of the cationic germicide deteriorates palatability.

[0009] Capsaicin is a spicy component contained in the pericarp of capsicum. For knowledge regarding its incorporation into oral compositions, see, for example, Japanese Unexamined Patent Publication No.
No. 251522, JP-A-11-228370 characterized in that it is contained as a bitter preparation, JP-A-2000-26260 for the purpose of providing a stimulus for preventing accidental ingestion, and the like. By the specific trace amount blend, it does not remind the refreshing effect of the flavor component such as l-menthol, the effect of enhancing the refreshing feeling.Moreover, since the described blending amount is as large as 10 ppm or more, there is irritation to the tongue, This does not solve the problem of the present invention. As the compounding amount of capsaicin, the concentration at the time of use is 0.1 to 4
ppm, and if less than 0.1 ppm, sufficient refreshing feeling and refreshing feeling cannot be obtained, and if it exceeds 4 ppm, there is irritation to the tongue,
The palatability worsens.

As the nonionic surfactant, one or a mixture of two or more of polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymer, and polyoxyethylene alkyl ether is preferable. As polyoxyethylene hydrogenated castor oil, the number of moles of polyoxyethylene added is preferably 40 to 80, and as the polyoxyethylene polyoxypropylene block copolymer, ethylene oxide in the total molecule is preferably 60% by mass or more. Examples include Pluronic F127, Pluronic F108, Pluronic F88, and Pluronic F68 of Asahi Denka Kogyo KK. Examples of the polyoxyethylene alkyl ether include polyoxyethylene lauryl ether having a polyoxyethylene addition mole number of 10 to 60 and polyoxyethylene lauryl ether. Oxyethylene myristyl ether, polyoxyethylene cetyl ether and polyoxyethylene stearyl ether are preferred, and one or a mixture of two or more thereof may be used. Further, as the nonionic surfactant, sucrose fatty acid ester, polyglycerin fatty acid ester, alkyl glycosides, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyldimethylamine oxide, and the like can also be used.

The flavor is a flavor containing l-menthol or one or more essential oils such as peppermint oil containing l-menthol, and the concentration of the flavor is suitable for a surfactant in the composition. Any amount may be used as long as the compounding amount is solubilized and transparent, but the preferred amount of l-menthol in the oral composition in the sense of cooling and palatability is 0.005 to 0.005.
0.1%.

The composition for liquid oral cavity of the present invention may contain, in addition to the above-mentioned components, appropriate optional components in accordance with the dosage form, depending on the type and the like. Specifically, as a thickener, sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylit, maltit, lactit, etc.
%).

In addition to the nonionic surfactants, anionic surfactants such as sodium lauryl sulfate, sodium dodecylbenzenesulfonate, sodium α-sulfofatty acid alkyl ester and alkyl phosphate ester salt, alkyldimethylaminoacetic acid Betaine acetate-type amphoteric surfactants such as betaine and fatty acid amidopropyldimethylaminoacetate betaine; imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt; N-fatty acid acyl-L -Amino acid type surfactants such as alginate salts can be added as long as the effects of the present invention are not impaired.

As a buffer, phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid and carbonic acid and their potassium salts, sodium salts and ammonium salts, amino acids and salts thereof, ribonucleic acids and salts thereof And sodium hydroxide, borax, hydrochloric acid bicarbonate, etc.
One or more species can be used, and the oral composition of the present invention is usually adjusted to pH 5 to 9.

Further, as optional components, for example, sweeteners such as saccharin sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatyl phenylalanine methyl ester, sucrose, fructose, sodium saccharinate, spearmint oil, wintergreen Oil, sassafras oil,
Clove oil, eucalyptus oil, sage oil, cassia oil, fennel oil, thyme oil, lemon oil, orange oil, carvone,
Anethole, cineole, cinnamaldehyde, p
-Methoxycinnamic aldehyde, ethyl acetate, ethyl butyrate, undecalactone, hexanal, allylcyclohexanepropionate, hexenol, l-menthol such as paramentan-1,3-diol, and other fragrances other than essential oils containing l-menthol, Non-cationic germicides such as triclosan, water-soluble polymers such as carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, sodium carboxymethylhydroxymethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, carrageenan, alginate, cationized cellulose, and hydroxyethylcellulose dimethyldiallylammonium chloride , Epsilon aminocaproic acid, tranexamic acid, dextranase, amylase, protease Mutanase, lysozyme, lytic enzyme, enzyme such as Ritekku enzyme, chlorhexidine salts, dehydrocholesterol, glycyrrhetinic salts,
Glycyrrhetinic acid, chlorophyca, caropeptides, vitamins, azulene, lysozyme chloride, anti-calculus agents, anti-plaque agents, potassium nitrate, aluminum lactate and other medicinal ingredients, and safety such as blue No. 1, green No. 3, yellow No. 4, etc. And a water-soluble dye having a high water content. In addition, the addition amount of these optional components can be a usual amount as long as the effects of the present invention are not impaired.

[0016]

According to the present invention, a highly palatable liquid oral composition having a refreshing sensation, a refreshing sensation and the like can be obtained without deactivating the cationic germicide.

[0017]

EXAMPLES Hereinafter, the present invention will be specifically described with reference to experimental examples, examples, and comparative examples, but the present invention is not limited to the following examples. In the following examples, the composition of the fragrance A is as follows. Perfume A perfume raw materials Compounding amount Spearmint oil 2.0 Anise oil 5.0 Caffeine oil 5.0 Eucalyptus oil 5.0 Winter green oil 2.0 Cardamom oil 1.0 Thyme oil 2.0 Coriander oil 1.0 Clove oil 5 2.0 Lemon oil 8.0 Orange oil 4.0 Cineol 5.0 Anethole 5.0 Carvone 2.0 Compounded flavor herbal mix 10.0 Compounded flavored fruit mix 15.0 Ethanol Residual total 100.0%

[Experimental Example 1] Evaluation of bactericidal activity The saliva-coated hydroxyapatite powder was treated with the components shown in Table 1, and the bactericidal activity of the cationic bactericide retained on the hydroxyapatite surface was measured against Actinomycosis neslandii T14V. The growth inhibition effect was evaluated by the following method. (1) Hydroxyapatite powder (manufactured by Asahi Optical Co., Ltd.) was used as a tooth model and immersed in filtered human saliva at 37 ° C. for 1 hour. (2) After removing saliva, the samples shown in Table 1 were added, and after shaking for 30 seconds, the powder was recovered and washed three times with distilled water. Table 1
The numbers in the capsaicin indicate ppm, and all other components are% (% by mass). (3) 10 mg of hydroxyapatite powder was collected, and 200 μl of a liquid medium (Brain Heart Infusion) was collected.
Was added. (4) 100 μl was taken from the above dispersion, and 100 μl of a liquid medium was added thereto to prepare a 2-fold dilution. This dilution step was repeated eight times to prepare a diluted dispersion up to 2 8 (512 times). (5) To each dispersion, add 10 μl of Actinomyces neslandii T14V bacteria pre-cultured in a liquid medium,
After anaerobic culturing for 24 hours, the presence or absence of bacterial growth was visually checked, and up to what dilution dilution the antibacterial activity was exhibited was determined. Evaluation of palatability With respect to the liquid oral composition shown in Table 1, sensory evaluation was performed on the feeling of use by 10 subjects. (1) 10 ml of the sample is contained in the mouth and rinsed for 30 seconds. (2) The feeling of use was evaluated on the following three scales, and the average score of ten persons was determined to be the feeling of use related to refreshing feeling. 3: Satisfactory refreshing feeling or refreshing feeling is obtained and excellent feeling of use is obtained 2: Refreshing feeling or refreshing feeling is obtained to some extent, but the feeling of use is insufficient 1: Refreshing feeling and refreshing feeling are insufficient Or a strong tongue irritation and poor feeling of use Comprehensive evaluation ：: A composition for liquid oral cavity with both excellent bactericidal power and palatability ：: A composition for liquid oral cavity with good bactericidal power and palatability △: Sterilization Liquid oral composition with insufficient power or palatability ×: Liquid oral composition with insufficient bactericidal power and palatability

[0019]

[Table 1]

From the results in Table 1, it is found that Examples 1 to 5 according to the present invention were used.
It was confirmed that the liquid oral composition of No. 7 was a liquid oral composition capable of obtaining palatability such as high refreshing feeling and refreshing feeling without inactivating the cationic germicide.

Hereinafter, Examples 8 to 14 were prepared as formulation examples of the oral composition of the present invention. The numerical values in the formulation examples are ppm for capsaicin, and all other components are% (% by mass).

Example 8 Liquid dentifrice Polyoxyethylene (60) hydrogenated castor oil 0.11 Cetylpyridinium chloride 0.05 Capsaicin 0.5 (ppm) l-menthol 0.03 Denatured ethanol 7 Citric acid 0.01 Trisodium citrate 0.3 Sodium saccharin 0.1 Glycerin 5 Xylitol 5 Fragrance A 0.1 Water Balance 100.0%

Example 9 Liquid Dentifrice Polyoxyethylene (20) Cetyl Ether 0.06 Cetyl Pyridinium Chloride 0.05 Capsaicin 0.3 (ppm) 1-Menthol 0.02 Peppermint Oil 0.01 Ethanol 10 Stevia 0 .05 citric acid 0.01 trisodium citrate 0.3 dye (blue No. 1) 0.01 glycerin 8 sodium monofluorophosphate 0.05 perfume A 0.1 water balance 100.0%

Example 10 Liquid dentifrice Pluronic F108 0.4 Benzethonium chloride 0.05 Capsaicin 1.5 (ppm) l-menthol 0.04 Ethanol 1 Glycerin 6 Saccharin sodium 0.05 Citric acid 0.01 Citric acid 3 Sodium 0.3 Antioxidant 0.01 Dextranase 0.5 Perfume A 0.1 Water Residual 100.0%

Example 11 Mouthwash Polyoxyethylene (60) hydrogenated castor oil 0.30 Stearyldimethylbenzylammonium chloride 0.05 Cetylpyridinium chloride 0.05 Capsaicin 3 (ppm) l-menthol 0.05 Saccharin sodium 0 .05 citric acid 0.01 trisodium citrate 0.3 sodium fluoride 0.05 xylitol 6 perfume A 0.2 water balance 100.0%

[Example 12] Mouthwash Polyoxyethylene (60) hydrogenated castor oil 0.14 Benzalkonium chloride 0.05 Capsaicin 0.5 (ppm) l-menthol 0.04 Peppermint oil 0.04 Ethanol 8 Saccharin sodium 0.05 Citric acid 0.01 Trisodium citrate 0.2 Sodium fluoride 0.02 Xylitol 8 Fragrance A 0.1 Water Balance 100.0%

Example 13 Mouthwash Polyoxyethylene (20) cetyl ether 0.15 N-coconut fatty acid acyl-L-arginine ethyl 0.05 DL-pyrrolidone carboxylate Benzalkonium chloride 0.05 Capsaicin 0.2 (ppm) Peppermint oil 0.06 Sodium saccharin 0.05 Citric acid 0.08 Sodium tripolyphosphate 0.5 Polyethylene glycol 1 Glycerin 4 Disodium hydrogen phosphate 0.3 Fragrance A 0.1 Water Balance 100. 0%

Example 14 Mouthwash Polyoxyethylene (60) hydrogenated castor oil 0.2 Cetylpyridinium chloride 0.05 Capsaicin 0.5 (ppm) 1-Menthol 0.06 90% Ethanol 20 Sodium citrate 0. 3 Perfume A 0.1 water balance 100.0%

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Seiji Kameda 1-3-7, Honjo, Sumida-ku, Tokyo Inside Lion Corporation (72) Inventor Takao Yokoo 1-3-7, Honjo, Sumida-ku, Tokyo F term in Lion Corporation (reference) 4C083 AA122 AB282 AB472 AC102 AC122 AC132 AC182 AC302 AC432 AC641 AC642 AC692 AC852 AC862 AD042 AD052 AD472 AD531 AD532 BB04 BB41 BB48 CC41 DD23 EE06

Claims (2)

[Claims] The present invention comprises a cationic fungicide, capsaicin, a nonionic surfactant, and l-menthol, wherein the cationic fungicide is used in an amount of 0.02 to 0.1% by mass at the time of use, and the capsaicin is used at the time of use. A composition for a liquid oral cavity, which is blended at a ratio of 0.1 to 4 ppm. 2. The method according to claim 1, wherein the nonionic surfactant is used in an amount of 0.0
The composition for a liquid oral cavity according to claim 1, which is blended at a ratio of 2 to 0.14% by mass.