JP2001302529A - Bile acid production promoter and food and drink - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for promoting bile acid production and a food or drink comprising a substance derived from a natural product as an active ingredient. SOLUTION: A tea extract obtained by extracting tea with warm water or hot water, for example, a bile acid production promoter and a food and drink containing a tea polyphenol such as tea catechin, theaflavin, and thealvidin as an active ingredient are prepared. By ingesting into the body can promote the production of bile acids in the liver,
It is effective for symptoms such as dyspepsia and lack of nutrients caused by decreased secretion of bile acids. Furthermore, it can control blood cholesterol concentration, and is expected to be effective in treating and preventing diseases caused by high blood cholesterol such as arteriosclerosis and colorectal cancer.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for promoting bile acid production which promotes the production of bile components such as bile acids and bile pigments, and a food and drink.

[0002]

2. Description of the Related Art Bile acids (generic term for steroidal carboxylic acids; used in the present invention to include salts of the acids) are one of the main components of bile and are used in the liver. Produced from cholesterol,
Most of them are conjugated with glycine and taurine to become glycocholate and taurocholate, which are stored in the gallbladder. By the way, bile acids stored in the gall bladder are secreted into the duodenum as bile through the common bile duct when the gall bladder contracts due to the inclusion of food in the mouth, etc., mixed with food, then reabsorbed from the intestine, and passed through the portal vein to the liver. And is again secreted as bile (enterohepatic circulation of bile acids).

[0003] This bile acid has a strong surface activity and can form micelles and take up cholesterol and long-chain fatty acids into the micelles. The role of bile acids in assisting digestion and absorption of dietary lipids and maintaining a constant cholesterol level is the most important role of bile acids. Bile acids also have various effects on the digestive activity of the body and play a significant role in the digestion and absorption of food. Recently, as a completely new function of bile acids, it has been found that bile acids act as ligands for nuclear receptors and have the effect of directly regulating gene transcription. That is, one of the nuclear receptors of bile acid (chenodeoxycholic acid)
FXR (fornesoid X receptor) suppresses the transcription of the rate-limiting enzyme that synthesizes bile acid from cholesterol by binding to chenodeoxycholic acid, and the gene for the bile acid-binding protein involved in bile acid reabsorption in the small intestine Has been reported to promote the transcription of cholesterol and contribute to the regulation of cholesterol levels in the body (Parks,
DJ et al .: Science, 284: 1365-1368, 1999, Wan
g, H. et al .: Mol. Cell, 3: 543-553, 1999).

[0004] Since bile acids play an important role in the body as described above, various symptoms such as indigestion, lack of nutrient sources, and elevated blood cholesterol level may be observed when secretion of bile acids is reduced. become. Therefore, conventionally, there has been a demand for the development of a substance that stimulates the secretion of bile acids when the secretion of bile acids decreases, that is, a useful and safe bile acid bile agent.

Conventionally, an anion exchange resin represented by cholestyramine and colestipol, chitosan which is a deacetylated product of chitin of animal fiber, and the like have been found to have a bile acid production promoting effect. As bile acid bile agents, ursosan (UDCA: Ursodesoxycholic acid), chenocole (CDCA: chenodeoxycholic acid) and the like are actually used. Among them, ursosan is useful for removing harmful bile acids, and therefore chronic hepatitis. It is also used in the treatment of intrahepatic cholestasis delayed by primary biliary cirrhosis, viral or drug-induced liver injury.

[0006] The present inventors have considered that some substances derived from natural products may have a bile acid production promoting effect. They succeeded in finding the present invention and came to the present invention based on such knowledge.

[0007]

Means for Solving the Problems The present invention relates to a bile acid production promoter and a food or drink containing, as an active ingredient, a tea extract obtained by extracting tea. Here, the tea extract means an extract obtained by extracting tea with warm water or hot water or an extract obtained by subjecting the extract to a drying treatment or the like. Is particularly preferred as the active ingredient of the present invention.

[0008] The bile acid production promoter and food and drink of the present invention
By ingesting into the body by oral ingestion, etc., it can promote the production of bile acids in the liver, and not only exerts effects on symptoms such as indigestion and lack of nutrients due to decreased bile acid secretion It can control blood cholesterol concentration, and is expected to be effective in treating and preventing diseases caused by high blood cholesterol, such as arteriosclerosis and colorectal cancer. In addition, as a bile acid bile agent, various hepatic diseases such as biliary tract (bile duct and gall bladder) system disease, liver disease accompanied by bile depression, hypertriglyceridemia, gallstone, and indigestion in small bowel resection sequelae and inflammatory small bowel disease. It is expected to be effective in treating and preventing functional diseases. In addition, since the present invention uses an active ingredient extracted from tea that has been commonly used for a long time, there is no concern about the safety to the human body.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION As described above, the bile acid production promoter and the food and drink of the present invention contain a tea extract obtained by extracting tea as an active ingredient.

In the present invention, "tea" refers to leaves, stems, and the like obtained from tea plants (Camellia sinensis) belonging to the family Camellia.
It means any of xylem, root, fruit, or a mixture of two or more of them. Fermented tea such as black tea, pual tea, oolong tea, semi-fermented tea such as wrapping tea, green tea, pot roasted green tea, roasted green tea, etc. May be used, and a mixture of two or more of these may be used.

As the tea extract, an extract obtained by extracting the above tea with water, hot water or hot water, preferably in hot water of 40 to 100 ° C. with hot water of 90 to 100 ° C., Preferably, the tea extract obtained by purifying this extract in a direction to increase the tea catechin content by purification means such as resin adsorption, filtration such as ultrafiltration, reverse osmosis filtration, or distribution extraction using ethyl acetate or the like. Alternatively, there may be mentioned a tea extract obtained by concentrating or drying these tea extracts. Specifically, green tea is subjected to hot water extraction treatment, and the extract is dried to obtain a green tea extract (trade name: Theafuran 30A, manufactured by ITO EN Co., Ltd.) having a tea catechin concentration of about 30%, or hot water extraction treatment for green tea. The extract was treated by a column method to remove components other than tea catechin and dried,
A green tea extract having a tea catechin concentration of about 85% (trade name: Theafran 90S, manufactured by Itoen Co., Ltd.) can be exemplified. Since these are commercially available products, they are suitable in that they contain tea catechins sufficiently and are easily available.

[0012] Examples of the tea extract include tea polyphenols such as catechin, theaflavin and thealvidin, among which the following tea catechins having a basic structure of flavan-3-ol, namely, (-)-epicatechin (EC), (-)-Epigallocatechin (EGC), (-)-Epicatechin gallate (EC
G), (-)-epigallocatechin gallate (EGCG), and its isomers (±) -catechin (C), (-)-gallocatechin (G
C), (-)-catechin gallate (CG), any one of (-)-gallocatechin gallate (GCG), or those obtained by mixing and mixing two or more thereof are preferable as the active ingredient of the present invention. Can be used.

The above-mentioned tea extract, tea polyphenol and catechin can each independently constitute the active ingredient of the present invention. Anion exchange resins such as cholestyramine and colestipol, chitosan and ursosan (UDCA) : Bile acid generation promoting effect can be expected if the active ingredient is composed in combination with a substance which has already been recognized as a bile acid generation promoting effect, such as ursodesoxycholic acid and kenochol (CDCA: chenodeoxycholic acid). . In addition, cholesterol-lowering action can be further enhanced by combining with foods that already have cholesterol-lowering action (polyunsaturated fatty acids such as linoleic acid, dietary fiber, lecithin, saponin) and pharmaceuticals (probucol, mevalotin). You can expect.

The above-mentioned tea extract, tea polyphenol, catechin, etc. are used for foods and drinks, food additives, feeds, feeds, etc. having medical effects such as pharmaceuticals, quasi-drugs, cosmetics, health foods and health drinks. It can be used as an active ingredient such as an agent, and as a use form, it can be provided as a dry powder by drying by freeze drying or spray drying,
Solutions, tablets, powders, granules, dragees, capsules, suspensions,
It can also be provided as an emulsion, ampoule, injection, or the like. For example, if prepared as a quasi-drug and provided in a drinkable form such as a bottled drink or in an easy-to-take form such as tablets, capsules, granules, etc., it is sufficient for a living body by taking it daily. Can produce pharmacological effects.

Although the content of the active ingredient in the present invention varies depending on the use, it is 0.001 to 1% by weight, particularly 0.01 to 0.1% by weight in terms of catechin dry weight in the case of pharmaceuticals.
It is preferable to mix 5% by weight. As the intake amount, 10 to 5000 mg per day in terms of catechin dry weight, preferably 50
About 0 to 1000 mg is preferable.

(Volunteer Test) In this test, nine volunteers were ingested five sugar-coated tablets (catechin tablets) containing 120 mg of theafuran 90S per tablet daily. As a result, the daily intake of theafuran 90S is 600 mg, and the daily intake of the catechin is as shown in Table 1 based on the catechin component content (% by weight) of the theafuran 90S.

[0017]

【table 1】

(Blood Sampling and Blood Test) Before taking the catechin tablet and two weeks after the drinking, blood was collected on an empty stomach in the morning. Serum was collected from the obtained blood by centrifugation, and serum total cholesterol and serum bile acids were measured.

[0019]

[Table 2]

(Results and Discussion) Table 2 shows test data on the effects of tea polyphenols on serum bile acids. As a result, it has been found that for volunteers having relatively high serum cholesterol, ingestion of tea polyphenol promotes bile acid production in vivo and increases serum bile acid concentration. In addition, no significant change in tea polyphenol was observed in volunteers having normal serum cholesterol levels.

Example 1 A tea extract was blended in the following ratio to prepare a tablet having a bile acid production promoting effect.

Tea extract (Theafuran 90S or Theafuran 30A)… 120 mg Vitamin C… 50 mg Emulsified oligosaccharide… 90 mg Granulating agent… 60 mg Crystalline cellulose… 80 mg Reduced maltose syrup… 90 mg Sucrose… 100 mg Flavor… Appropriate amount

Example 2 A tea extract was blended in the following ratio to prepare a beverage having a bile acid production promoting effect.

Tea extract (Theafran 90S or Theafuran 30A)… 150 mg Vitamin C… 50 mg Fructose grape sugar… 10 g Water-soluble dietary fiber… 500 mg Flavor… Appropriate amount Ion-exchanged water… adjusted to 100 mL

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 31/353 A61P 1/16 101 A61P 1/16 101 A23L 2/00 F (72) Inventor Teruaki Matsui Tokyo 1-21-2-401, Wakagi, Itabashi-ku (72) Inventor Kazuhiro Imatake 2-7 Tsuruse Nishi, Fujimi-shi, Saitama Albis-Tsuruse 2-902 (72) Inventor Kazuhiko Shimbashi 1-10 Toyotamanaka, Nerima-ku, Tokyo -4 (72) Inventor Kenichi Takasago 4-21-25-407, Ogikubo, Suginami-ku, Tokyo (72) Inventor Hideki Sato 1-13-16-1103, Narimasu, Itabashi-ku, Tokyo (72) Inventor Miyo Iida, Itabashi, Tokyo 57-3-502, Otaniguchi-Kitacho, Ward (72) Inventor Hidetoshi Yamazaki 5-21-7-205 Nishiikebukuro, Toshima-ku, Tokyo F-term (reference) 4B017 LC03 LG14 LL09 LP01 4B018 LB08 LE05 MD59 MD60 ME14 MF01 4B027 FB01 FB08 FB10 FB1 3 FC06 FP72 FP85 4C086 BA08 NA14 ZA76 4C088 AB45 AC05 BA09 CA05 NA14 ZA76

Claims (4)

[Claims] 1. A bile acid production promoter comprising, as an active ingredient, a tea extract obtained by extracting tea with warm water or hot water. (2) (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate, (-)-epigallocatechin gallate, (±) -catechin, (-)-gallocatechin, (- A bile acid production promoter containing, as an active ingredient, a tea polyphenol obtained by mixing any one of-)-catechin gallate, (-)-gallocatechin gallate, theaflavin, and thearvidin, or a combination of two or more thereof. 3. A bile acid production-promoting food or drink comprising, as an active ingredient, a tea extract obtained by extracting tea with warm or hot water. (4) (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate, (-)-epigallocatechin gallate, (±) -catechin, (-)-gallocatechin, ( A bile acid production-promoting food or beverage containing, as an active ingredient, a tea polyphenol obtained by mixing any one of-)-catechin gallate, (-)-gallocatechin gallate, theaflavin, and thearvidin, or a combination of two or more thereof.