JP2001288019A - Virucidal composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a virucidal composition having high virucidal effect and excellent in safety and operability. SOLUTION: This virucidal composition comprises one or more kinds (A) selected from hypochlorites and hypochlorous acid, one or more kinds of (B) amphoteric surfactants and cationic surfactants and a pH adjusting agent (C).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a virucidal composition.

[0002]

2. Description of the Related Art Medical machines, instruments, and equipment used in hospitals, nursing homes, and the like must be sufficiently sterilized and washed from the viewpoint of preventing internal infection. Various bactericides, disinfectants and the like for performing such a germicidal washing treatment are known, but a bactericide for general bacteria is insufficient for treating a virus having a high chemical resistance, and has a broad antibacterial spectrum. Glutaraldehyde and peracetic acid are used. Further, Japanese Patent Application Laid-Open No. 8-502047 discloses that an aqueous solution containing a specific molar ratio of an aliphatic peracid and a corresponding aliphatic acid and hydrogen peroxide is used as a virus killer.

[0003] As an example of a sterilization cleaning treatment using glutaraldehyde or peracetic acid, for example, in sterilization cleaning of an endoscope, a primary treatment using a quaternary ammonium salt-based disinfectant, alcohol, acidic water, amphoteric surfactant or the like is performed. After a disinfection and a washing step using an enzyme preparation or a neutral detergent, a sterilization treatment with glutaraldehyde or peracetic acid is performed. Further, other heatable medical instruments and the like are subjected to autoclave disinfection and dry heat sterilization as necessary.

[0004]

However, since the above-described processing takes a very long time, further reduction and simplification of the steps are desired. At that time, it is necessary to obtain a reliable virus killing effect. In addition, glutaraldehyde has a problem that toxic gas of aldehyde is generated to lower the working environment, and that it reacts with a protein adhering to a medical device or the like to form a fixed substance, which makes cleaning difficult. On the other hand, peracetic acid has a strong irritating odor and a strong oxidizing power, so that depending on the material, there is a possibility that the packaging container, the object to be treated and the like may be corroded. The same applies to an aqueous solution containing a peracid and hydrogen peroxide as disclosed in JP-T-Hei-8-502047.

[0005] It is an object of the present invention to obtain a virucidal composition which can provide a reliable virucidal effect by a simple treatment and is excellent in safety and workability.

[0006]

According to the present invention, there is provided at least one kind selected from hypochlorite and hypochlorous acid (A), and at least one kind selected from amphoteric surfactants and cationic surfactants. The present invention relates to a virucidal composition containing (B) and a pH adjuster (C).

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION As the hypochlorite of the component (A), alkali metal hypochlorites such as potassium hypochlorite and sodium hypochlorite, calcium hypochlorite, and hypochlorite Alkaline earth metal hypochlorites such as magnesium oxychloride and the like, and alkali metal hypochlorites are preferable,
Particularly, sodium hypochlorite is preferable. The component (A)
The effective chlorine concentration of the composition is preferably 1 to 10,000 pp
m, more preferably 10 to 5000 ppm, even more preferably 50 to 2000 ppm.

Examples of the amphoteric surfactant (B) include amine oxides such as alkyldimethylamine oxide, betaines such as alkyldimethylamino fatty acid betaine and alkylcarboxymethylhydroxyethyl imidazolium betaine. Above all, carbon number 8-1
Alkyl dimethylamine oxide having an alkyl group of 8 is preferred. Examples of the cationic surfactant of the component (B) include a primary amine salt, a secondary amine salt, a tertiary amine salt, and a quaternary ammonium salt. Is particularly preferred. As the quaternary ammonium salt, at least one of the four substituents is an alkyl or alkenyl group having 8 to 28 carbon atoms in total, and the remainder is a benzyl group, an alkyl group having 1 to 5 carbon atoms, and an alkyl group having 1 to 5 carbon atoms. And a compound which is a group selected from a hydroxyalkyl group. An alkyl or alkenyl group having a total of 8 to 28 carbon atoms may be an alkoxyl group,
An alkenyloxy group, an alkanoylamino group, an alkenoylamino group, a composition of the present invention which may be substituted with an alkanoyloxy group or an alkenoyloxy group,
(B) 1 ppm to 10% by weight of the component, further 10 ppm to
It is preferable to contain 5% by weight, particularly 50 ppm to 2% by weight.

In the composition of the present invention, the weight ratio of the component (A) to the component (B) is (A) / (B) = 10/1 to 1
/ 10, and more preferably 5/1 to 1/10.
It is 1/5, particularly preferably 5/1 to 1/2.

Examples of the pH adjuster (C) include an alkali metal hydroxide, an alkaline earth metal hydroxide, an inorganic acid or a salt thereof, an organic acid or a salt thereof, and the like. Alkali metal hydroxides, alkaline earth metal hydroxides,
Examples include sodium hydroxide, potassium hydroxide, calcium hydroxide and the like. Inorganic acids or salts thereof include hydrochloric acid, sulfuric acid, sodium sulfate, sodium nitrate, sodium chloride, sodium carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, magnesium sulfate, magnesium nitrate, magnesium chloride, magnesium carbonate, phosphoric acid Trisodium, tripotassium phosphate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, sodium polyphosphate and the like can be mentioned. As the organic acid or a salt thereof, malonic acid,
Saturated dibasic acids such as succinic acid, glutaric acid, adipic acid and sebacic acid or salts thereof, and unsaturated dibasic acids such as fumaric acid and maleic acid or salts thereof are exemplified. Preferably a saturated dibasic acid or a salt thereof, more preferably 3 to 10 carbon atoms
And particularly preferred is succinic acid or a salt thereof.

The composition of the present invention has a pH (20 ° C.) of 3 to
8, more preferably 5 to 8, particularly preferably 5 to 7.
The component (C) is preferably used in such an amount that the pH falls within this range.

Further, the composition of the present invention may contain an anionic surfactant. As anionic surfactants, higher fatty acid salts, higher alcohol sulfates,
Higher alcohol sulfonate, sulfated fatty acid salt, sulfonated fatty acid salt, phosphate ester salt, fatty acid ester sulfate ester salt, fatty acid ester sulfonate ester salt, higher alcohol ether sulfate ester salt, higher alcohol ether sulfonic acid Ester salts, acetates substituted with higher alcohol ethers, condensates of fatty acids and amino acids, alkylolated sulfates of fatty acid amides, alkylated sulfonates of fatty acid amides, sulfosuccinates, alkylbenzenesulfonates, alkylphenolsulfonic acids Salt, alkyl naphthalene sulfonate, alkyl benzimidazole sulfonate, amide ether carboxylic acid or salt thereof, ether carboxylic acid or salt thereof, N-acyl-N-methyltaurine or salt thereof, amide ether sulfate Or a salt, N- acyl glutamic acid or its salt, N- amidoethyl -N- hydroxyethyl acetate or a salt thereof, acyloxyalkyl ethanesulfonic acid or a salt thereof, N- acyl -β- alanine or a salt thereof, N
-Acyl-N-carboxyethyltaurine or a salt thereof,
Examples include N-acyl-N-carboxyethylglycine or a salt thereof, and alkyl or alkenylaminocarbonylmethyl sulfate or a salt thereof. The amount of the anionic surfactant may be 1 ppm to 50% by weight in the composition, and 1% to 50% by weight.
0 ppm to 5% by weight, particularly preferably 50 ppm to 2% by weight, is preferred.

[0013] In addition to the above components (A) to (C), the virucidal composition of the present invention may contain an inorganic compound such as tripolyphosphate, pyrophosphate, carbonate, percarbonate, silicate or sulfate. Builders, ethylenediaminetetraacetate, aminotrimethylenephosphonate, 1-hydroxy-1,1-diphosphonate, ethylenediaminetetramethylenephosphonate, diethylenetriaminepentamethylenephosphonate, citrate, gluconate, poly Acrylic acid salts, acrylic acid-maleic acid copolymers, organic builders such as carboxymethylcellulose, low-foaming nonionic surfactants, enzymes and the like can also be appropriately blended.

The composition of the present invention is suitable for an automatic cleaning device. Here, the automatic cleaning device refers to a general device for automatically cleaning an endoscope, a medical instrument, or the like, and is not limited to the type of the device. Virucidal treatment using this is preferably performed after the washing step in principle from the viewpoint of the effect.

[0015]

According to the present invention, a virucidal composition having a high virucidal effect and excellent in safety and workability can be obtained.

[0016]

EXAMPLES Examples 1 to 6 and Comparative Examples 1 to 4 (1) Preparation of Virucidal Compositions The compositions of Examples 1 to 5 and Comparative Examples 1 to 3 in Table 1 were prepared by adding sodium hypochlorite aqueous solution. (Effective chlorine concentration 60000pp
m) and a predetermined amount of component (B) or component (D) are mixed and diluted with ion-exchanged water to twice the final compounding concentration, and succinic acid is ion-exchanged to twice the final compounding concentration. Was obtained by mixing equal amounts of the components diluted with.

[0017] Of the so-called electrolytic oxidized water obtained by the diaphragm method, hypochlorous acid water (pH (2)
(5 ° C) 2.7, effective chlorine concentration 50 ppm)
The pH was adjusted to 11 with a 1 mol / L aqueous sodium hydroxide solution to obtain a composition of Comparative Example 4 in Table 1. Further, after adjusting the pH of the above hypochlorous acid aqueous solution to pH 5 with a 1 mol / L aqueous solution of disodium succinate, lauryl dimethylamine oxide (the same as in Example 1) was added so that the concentration became 25 ppm. The composition of Example 6 was obtained.

The effective chlorine concentration in Table 1 is based on JIS
It is measured by K-0101 "Iodine method".

A sterilizing performance test was performed by the following method using a test aqueous solution obtained by diluting these compositions to have the effective chlorine concentration shown in Table 1 (the compositions were used as they were in Example 6 and Comparative Example 4). Was. Table 1 shows the results.

(2) Evaluation of virucidal performance <Target virus> (i) Poliovirus: poliovirus type 3, vaccine strain (Sabin strain) (ii) Herpes simplex virus: HF strain FL cells were used for the measurement.

<Test method> Virucidal composition 5 shown in Table 1
Mix 0 μl and 50 μl of virus solution. Leave for 30 minutes at 20 ° C. and leave 2% sodium thiosulfate aqueous solution 50
Add μl. This mixture is serially diluted 10-fold, and the virus infection titer is measured. As a virus control, 50% of each preparation was added to a 5% aqueous solution of 2% sodium thiosulfate.
After adding 0 μL and leaving the mixture to stand for 30 minutes, the virus liquid 50 was added.
μL was added.

[0022]

[Table 1]

(1): The value in parentheses indicates the effective chlorine concentration. (2): Amphitol 20N (manufactured by Kao Corporation, effective component 3)
5%) so that the concentration of the active ingredient became the value in Table 1. (3): Sanizole C (manufactured by Kao Corporation, effective content 50%)
The concentration of the effective component was adjusted to the value shown in Table 1 by using. (4): Emar 20C (manufactured by Kao Corporation, effective component 25)
%), The concentration of the active ingredient was adjusted to the value shown in Table 1. (5): Using Emulgen 106 (manufactured by Kao Corporation), the effective component concentration was adjusted to the value shown in Table 1.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Tetsuya Okano 1334 Minato, Wakayama City, Wakayama Prefecture, Kao Corporation (72) Inventor Sumitomo Ito 1334 Minato, Minato, Wakayama City, Wakayama Prefecture, Kao Corporation (72) Invention Person Shigeru Tamura 1334 Minato, Wakayama-shi, Wakayama Prefecture F-term in Kao Corporation Research Institute 4H011 AA04 BA01 BA05 BB04 BB18 BC05 BC06 BC07 DA13

Claims (5)

[Claims] 1. A pH adjuster comprising at least one kind selected from hypochlorite and hypochlorous acid (A), at least one kind selected from amphoteric surfactants and cationic surfactants (B), and a pH adjuster (C). 2. The virucidal composition according to claim 1, wherein the effective chlorine concentration is 1 to 10000 ppm. 3. The virucidal composition according to claim 1, wherein the pH adjuster (C) is at least one selected from organic acids and salts thereof. 4. The virucidal composition according to claim 1, further comprising an anionic surfactant. 5. The virucidal composition according to claim 1, which comprises an amine oxide as the component (B).