JP2001286484A - Device for decreasing body fat - Google Patents
Device for decreasing body fatInfo
- Publication number
- JP2001286484A JP2001286484A JP2000104323A JP2000104323A JP2001286484A JP 2001286484 A JP2001286484 A JP 2001286484A JP 2000104323 A JP2000104323 A JP 2000104323A JP 2000104323 A JP2000104323 A JP 2000104323A JP 2001286484 A JP2001286484 A JP 2001286484A
- Authority
- JP
- Japan
- Prior art keywords
- ffa
- ultrasonic irradiation
- electric muscle
- fat
- ultrasonic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000577 adipose tissue Anatomy 0.000 title abstract 3
- 230000003247 decreasing effect Effects 0.000 title 1
- 210000003205 muscle Anatomy 0.000 claims abstract description 24
- 230000000694 effects Effects 0.000 claims abstract description 9
- 241000124008 Mammalia Species 0.000 claims abstract description 7
- 230000000638 stimulation Effects 0.000 claims description 14
- 230000004130 lipolysis Effects 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 6
- 230000000476 thermogenic effect Effects 0.000 claims description 5
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 claims description 3
- 229960004203 carnitine Drugs 0.000 claims description 3
- 230000004936 stimulating effect Effects 0.000 claims description 3
- 229940057857 capsin Drugs 0.000 claims 1
- JBFKSLZFABCEAI-UHFFFAOYSA-N capsin Natural products CC(C)(O)C1CCC(C)(O1)C2CCC3(CO)C2C(O)CC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6O)C(C)(C)C5CCC34C JBFKSLZFABCEAI-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract description 6
- 239000012752 auxiliary agent Substances 0.000 abstract 1
- 235000021588 free fatty acids Nutrition 0.000 description 16
- 239000008280 blood Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 208000008589 Obesity Diseases 0.000 description 3
- 210000001789 adipocyte Anatomy 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 230000003187 abdominal effect Effects 0.000 description 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 230000002366 lipolytic effect Effects 0.000 description 2
- 210000004003 subcutaneous fat Anatomy 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- ZXVONLUNISGICL-UHFFFAOYSA-N 4,6-dinitro-o-cresol Chemical compound CC1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1O ZXVONLUNISGICL-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229960002504 capsaicin Drugs 0.000 description 1
- 235000017663 capsaicin Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000004146 energy storage Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000001113 umbilicus Anatomy 0.000 description 1
Landscapes
- Surgical Instruments (AREA)
- Electrotherapy Devices (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】哺乳類の肥満を解消する分野
に属し、機械的および又は電気的刺激装置に関わる。TECHNICAL FIELD The present invention belongs to the field of relieving obesity in mammals and relates to mechanical and / or electrical stimulators.
【０００２】[0002]
【従来の技術】本発明者等はＰＣＴ国際出願公開ＷＯ９
９／３９６７７に特定周波数と強度の超音波を照射して
脂肪が分解し遊離脂肪酸がすることを開示した。これは
その後の追試でラットへの１０分程度の照射で血中の遊
離脂肪酸（ＦＦＡ）が約倍増する事、また超音波照射が
照射部位の交感神経を刺激して脂肪分解ホルモンである
ノルエピネフリン（ＮＥ）がやはり倍増する事が確認さ
れた。ＮＥは脂肪細胞の脂肪分解を生起しＦＦＡとグリ
セロールを血中に放出すると推定される。2. Description of the Related Art The present inventors have disclosed PCT International Application Publication WO9.
On 9/39677, it was disclosed that fat is decomposed and free fatty acids are generated by irradiating ultrasonic waves of a specific frequency and intensity. This is because, in a subsequent follow-up test, the free fatty acids (FFA) in the blood are approximately doubled by irradiating the rats for about 10 minutes, and the ultrasonic irradiation stimulates the sympathetic nerve at the irradiated site, and the lipolytic hormone norepinephrine ( NE) was also confirmed to double. It is presumed that NE causes lipolysis of fat cells and releases FFA and glycerol into the blood.
【０００３】ヒト右大腿部、腹部臍右の１０分間／日、
１０日間の超音波照射で照射部局所の皮下脂肪厚が非照
射の左大腿、腹部臍左に比して約１２〜１８％減少が確
認されている。これはＦＦＡ燃焼のために照射後約６０
ｋｃａｌの運動をしたが、一部運動しないヒトも２０％
の減少を見せた。１日の運動量約２０００Ｋｃａｌであ
るから６０ｋｃａｌの意義は明確でない。[0003] Human right thigh, abdominal right umbilicus 10 minutes / day,
It has been confirmed that the subcutaneous fat thickness at the irradiated part is reduced by about 12 to 18% in 10 days of ultrasonic irradiation as compared with the non-irradiated left thigh and abdominal left navel. This is about 60 hours after irradiation due to FFA combustion.
20% of people who exercised kcal but did not exercise partly
Showed a decrease. Since the daily momentum is about 2000 Kcal, the significance of 60 kcal is not clear.
【０００４】一方シーメンス社は電気筋肉刺激装置を開
示し、商品としてステレオダイネータＳＤ−８２８を発
売している。これは約１５ｋＨｚの電流を体表に接触さ
せた電極から筋肉に流しこの刺激で筋肉収縮を生起し之
を繰り返す事で筋肉を運動させたと同様の効果を得るこ
とを目的としている。２０〜５０ｍＡを約３０〜４０分
適用する。体表温度の４℃程度の上昇と約１時間の継続
が観察されている。On the other hand, Siemens has disclosed an electric muscle stimulator, and has sold a stereo dilator SD-828 as a commercial product. This is intended to obtain the same effect as exercising the muscle by causing a current of about 15 kHz to flow from the electrode in contact with the body surface to the muscle, causing the muscle to contract by this stimulation, and repeating the same. Apply 20-50 mA for about 30-40 minutes. A rise in body surface temperature of about 4 ° C. and a continuation of about 1 hour have been observed.
【０００５】長時間の筋肉の運動はまず食物摂取からの
血中糖質を消費し、やがてエネルギー備蓄源の脂肪を分
解しての血中脂肪酸の消費を開始する。これは血中エネ
ルギー源補給の要求が脳に達し視床下部から脂肪分解ホ
ルモンの生成指令が出され、脂肪細胞で脂肪が分解して
ＦＦＡの生成が結果されると考えられる。この脂肪分解
が筋運動局所近傍で生じるか、全身的に生じるかは明確
でない。[0005] Prolonged muscular exercise first consumes blood sugar from food intake and then begins to consume blood fatty acids by breaking down the fat from the energy storage source. This is thought to be because the request for blood energy source supply reaches the brain, a command to generate lipolytic hormone is issued from the hypothalamus, and fat is decomposed in fat cells to generate FFA. It is not clear whether this lipolysis occurs near the locality of muscle exercise or systemically.
【０００６】[0006]
【発明が解決しようとする課題】超音波照射における発
生血中ＦＦＡを確実に燃焼する方式望ましくはヒトや動
物にとって大儀な運動等を要せずに燃焼する方式が望ま
れる。一方電気筋刺激では局所的な脂肪分解を明確に確
保する必要がある。SUMMARY OF THE INVENTION A method of reliably burning FFA in blood generated by ultrasonic irradiation, preferably a method of burning without the need for heavy exercises for humans and animals. On the other hand, it is necessary to clearly secure local lipolysis in electromuscular stimulation.
【０００７】[0007]
【課題を解決するための手段】手段１： 哺乳類に対し
て超音波照射による脂肪分解と電気筋肉刺激による脂肪
分解生成物の消費とを併用することを特徴とする脂肪減
少方式とその装置を用いる。Means 1: The lipolysis method is characterized in that lipolysis by ultrasound irradiation and consumption of lipolysis products by electric muscle stimulation are used in combination for mammals, and a fat reduction method and an apparatus therefor are used. .
【０００８】手段２： 手段１の併用がいずれかの適用
と同時,又はその有効効果の残留中に他を適用すること
を特徴とする超音波照射装置又は電気筋肉刺激装置を用
いる。Means 2: An ultrasonic irradiation apparatus or an electric muscle stimulating apparatus characterized in that the combination of the means 1 is applied simultaneously with any application, or the other is applied while its effective effect remains.
【０００９】手段３： 手段1において超音波照射アプ
リケータと電気筋肉刺激電極とが一体にされた事を特徴
とする脂肪減少装置を用いる。Means 3: A fat reduction apparatus characterized in that the ultrasonic irradiation applicator and the electric muscle stimulating electrode are integrated in the means 1.
【００１０】手段４： 手段１において超音波アプリケ
ータの皮膚表面接触部が電気筋肉刺激電極をかねている
ことを特徴とする脂肪減少装置を用いる。Means 4: A fat reduction apparatus according to means 1, characterized in that the skin surface contact portion of the ultrasonic applicator also functions as an electric muscle stimulation electrode.
【００１１】手段５： 手段１において更に熱産生剤
（カプサイン等）、熱産生助剤（カルニチン等）の投与
効果有効期間中に少なくとも超音波照射、電気筋肉刺激
のいずれかを適用するか,又はいずれかの適用効果存続
期間中に熱産生剤を投与することを特徴とする脂肪減少
方式とその装置を用いる。Means 5: At least one of ultrasonic irradiation and electric muscle stimulation is applied during the effective period of administration of a heat-generating agent (capsine or the like) or a heat-generating aid (carnitine or the like) in the means 1, or A fat-reducing system characterized in that a thermogenic agent is administered during the duration of any of the applied effects and a device therefor are used.
【００１２】[0012]
【発明の実施の形態】態様１：手段１により超音波照射
機器と電気筋肉刺激装置とを併用する。先ず超音波照射
によりＦＦＡを血中に生成する。これは１０分程度の照
射で既に発生する。ついで電気筋肉刺激装置を併用すれ
ば発生ＦＦＡは既存の摂食糖質とともに同時に消費され
る。したがって電気筋肉刺激装置の適用を長時間行い先
ず摂食糖質の消費後の脂肪分解を待つ必要がなく短時間
で脂肪減少がえられる。DESCRIPTION OF THE PREFERRED EMBODIMENTS Aspect 1: The ultrasonic irradiation device and the electric muscle stimulator are used in combination by means 1. First, FFA is generated in blood by ultrasonic irradiation. This already occurs with irradiation for about 10 minutes. Then, if an electric muscle stimulator is used in combination, the generated FFA is simultaneously consumed with the existing carbohydrate. Therefore, the application of the electric muscle stimulator can be performed for a long time, and it is not necessary to first wait for the lipolysis after consumption of the ingested carbohydrate, and the fat can be reduced in a short time.
【００１３】態様２：手段２に示すごとく超音波と電気
刺激を同時に適用してよい。摂食糖質の消費とＦＦＡの
発生が同時に起こるがＦＦＡの存在と電気筋肉刺激によ
るＦＦＡ消費が同時に存在すればよい。何れもその状態
はかなりの時間存続するので相互の時間ずれはゆるされ
る。即ち夫々の有効期間に他の有効期間が重なればよい
ので相互に前後してよい。Embodiment 2: As shown in the means 2, ultrasonic waves and electrical stimulation may be applied simultaneously. Consumption of fed carbohydrate and generation of FFA occur simultaneously, but it is sufficient that the presence of FFA and the consumption of FFA by electric muscle stimulation simultaneously exist. In each case, the state lasts for a considerable time, so that the mutual time lag is relaxed. In other words, it is only necessary that the other valid periods overlap with the respective valid periods, so that the valid periods may be set before and after each other.
【００１４】態様３：超音波照射機と電気筋肉刺激機と
は夫々別個でもよく手段３に示すように夫々のアプリケ
ータが同一体とされていてもよい。この場合は取り扱い
が便利である。哺乳類の腹部等をなるべく広く照射する
には圧電セラミック等の単位トランスデューサーを複数
配列した広いアプリケータが望ましい。このアプリケー
タに適宜数の電気刺激電極を設ける事ができる。Embodiment 3: The ultrasonic irradiator and the electric muscle stimulator may be separate from each other, or each applicator may be the same as shown in Means 3. In this case, handling is convenient. In order to irradiate the mammal's abdomen and the like as widely as possible, a wide applicator in which a plurality of unit transducers such as piezoelectric ceramics are arranged is desirable. This applicator can be provided with an appropriate number of electrostimulation electrodes.
【００１５】態様４：また手段４に示すごとく超音波照
射アプリケータ表面が電気刺激機の電極を兼ねていても
よい。これは超音波アプリケータの表面を超音波吸収の
少ない薄い導電層としこれに筋刺激電気を与えればよ
い。材質は皮膚接触障害の少ない貴金属、炭素等がのぞ
ましい。超音波ゼリーも有機性導電性成分を含有させる
とよい。筋刺激電流は２０〜５０ｍＡ程度であり電極、
ゼリーともそれほどの電気伝導度は必要ない。Aspect 4: As shown in Means 4, the surface of the ultrasonic irradiation applicator may also serve as an electrode of the electric stimulator. In this case, the surface of the ultrasonic applicator may be formed as a thin conductive layer having little ultrasonic absorption, and the muscle stimulation electricity may be applied thereto. The material is preferably noble metal, carbon or the like, which has little skin contact obstacle. The ultrasonic jelly may also contain an organic conductive component. The muscle stimulation current is about 20-50 mA and the electrodes
Jellies do not need that much electrical conductivity.
【００１６】態様５：上述のＰＣＴ出願には肥満解消剤
と超音波照射とを複合する照射機が開示されている。本
特許でも同様に肥満解消剤特に服用によりＦＦＡを燃焼
するカプサイシンのような熱産生剤，ＦＦＡを利用して
エネルギーに変換し最終的には熱とする即ち燃焼する筋
肉細胞中のミトコンドリアにＦＦＡを運ぶ込むカルニチ
ンのような熱産生助剤の併用が効果を増進する。服用後
適宜の時間経過して吸収されその効果があらわれる。こ
の効果が持続している間に手段１を実施するとよい。Embodiment 5: The above-mentioned PCT application discloses an irradiation machine that combines an obesity-relieving agent and ultrasonic irradiation. This patent also uses an obesity-relieving agent, in particular, a heat-producing agent such as capsaicin, which burns FFA by taking it, and converts it into energy using FFA, and finally converts it into heat, that is, mitochondria in the burning muscle cells. Combined use of a thermogenic aid such as carnitine to carry in enhances the effect. It is absorbed after an appropriate period of time after taking and its effect appears. Means 1 may be implemented while this effect is sustained.
【００１７】[0017]
【発明の効果】本発明によれば超音波照射で照射部のＮ
Ｅ放出付近の脂肪細胞の分解によるＦＦＡの発生と血中
移行、電気筋肉刺激による血中ＦＦＡの消費燃焼が一貫
して行われ、哺乳類が特に運動することなく脂肪を減少
する事ができる。哺乳類の生体局所の皮下脂肪減少即ち
局部痩せが実現できる。According to the present invention, the ultrasonic irradiation irradiates the N
Generation of FFA due to the decomposition of fat cells near E release and transfer into the blood, consumption and burning of FFA in the blood by electric muscle stimulation are performed consistently, and the mammal can reduce fat without particularly exercising. Subcutaneous fat reduction, that is, local thinning, in a living body of a mammal can be realized.
Claims (5)
解と電気筋肉刺激による脂肪分解生成物の消費とを併用
することを特徴とする脂肪減少方式とその装置。1. A fat reduction method and apparatus, wherein a lipolysis by ultrasonic irradiation and consumption of a lipolysis product by electric muscle stimulation are used in combination for a mammal.
時,又はその有効効果の残留中に他を適用することを特
徴とする超音波照射装置又は電気筋肉刺激装置。2. An ultrasonic irradiation device or an electric muscle stimulating device, wherein the combination of claim 1 is applied simultaneously with any application or while the effective effect remains.
タと電気筋肉刺激電極とが一体にされた事を特徴とする
脂肪減少装置。3. The fat reduction device according to claim 1, wherein the ultrasonic irradiation applicator and the electric muscle stimulation electrode are integrated.
皮膚表面接触部が電気筋肉刺激電極をかねていることを
特徴とする脂肪減少装置。4. The fat reduction device according to claim 1, wherein a skin surface contact portion of the ultrasonic applicator also functions as an electric muscle stimulation electrode.
イン等）、熱産生助剤（カルニチン等）投与効果有効期
間中に少なくとも超音波照射、電気筋肉刺激のいずれか
を適用するか,又はいずれかの適用効果存続期間中に熱
産生剤を投与することを特徴とする脂肪減少方式とその
装置。5. The method according to claim 1, wherein at least one of ultrasonic irradiation and electric muscle stimulation is applied during the effective period of the administration of the thermogenic agent (such as capsin) and the thermogenic auxiliary (such as carnitine), or any of them. And a device for reducing fat, which comprises administering a thermogenic agent for the duration of the application effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000104323A JP2001286484A (en) | 2000-04-06 | 2000-04-06 | Device for decreasing body fat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000104323A JP2001286484A (en) | 2000-04-06 | 2000-04-06 | Device for decreasing body fat |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001286484A true JP2001286484A (en) | 2001-10-16 |
| JP2001286484A5 JP2001286484A5 (en) | 2005-04-14 |
Family
ID=18617883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000104323A Pending JP2001286484A (en) | 2000-04-06 | 2000-04-06 | Device for decreasing body fat |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2001286484A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7914469B2 (en) | 2003-03-13 | 2011-03-29 | Real Aesthetics Ltd. | Cellulite ultrasound treatment |
| US8454540B2 (en) | 2001-10-29 | 2013-06-04 | Yoram Eshel | Non-invasive ultrasonic body contouring |
| CN113873983A (en) * | 2019-03-11 | 2021-12-31 | 明尼苏达大学董事会 | Systems and methods of combined ultrasound and electrical stimulation for treating a subject |
-
2000
- 2000-04-06 JP JP2000104323A patent/JP2001286484A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8454540B2 (en) | 2001-10-29 | 2013-06-04 | Yoram Eshel | Non-invasive ultrasonic body contouring |
| US7914469B2 (en) | 2003-03-13 | 2011-03-29 | Real Aesthetics Ltd. | Cellulite ultrasound treatment |
| JP4774500B2 (en) * | 2003-03-13 | 2011-09-14 | リアル エステテックス リミテッド | Cellulite ultrasonic treatment system |
| CN113873983A (en) * | 2019-03-11 | 2021-12-31 | 明尼苏达大学董事会 | Systems and methods of combined ultrasound and electrical stimulation for treating a subject |
| JP2022524422A (en) * | 2019-03-11 | 2022-05-02 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | Systems and methods for combined ultrasound and electrical stimulation to treat patients |
| US12496447B2 (en) | 2019-03-11 | 2025-12-16 | Regents Of The University Of Minnesota | Systems and methods for combined ultrasound and electrical stimulation for treating a subject |
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