JP2001261545A - Skin care preparation for prevention of chapped skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation for prevention of chapped skin, having platelet activation factor antagonism and having effect on improvement and prevention of chapped skin symptom due to various kinds of skin diseases such as atopic dermatitis, contact dermatitis, eczema and psoriasis and chapped skin of healthy persons. SOLUTION: This skin care preparation is obtained by formulating an extract of Boesenbergia pandurataSchl which is a plant of the genus Zingiber of the family Zingiberaceae, an extract of Kaempferia angustifolia which is a plant of the genus Kaempferia of the family Zingiberaceae or an extract of Phyllanthus niruri L. which is a plant of the genus Phyllanthus of the family Euphor biaceae as an active ingredient.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for preventing skin roughness, and more particularly to a skin external preparation having a platelet activating factor antagonism and having various skin diseases such as atopic dermatitis, contact dermatitis, eczema and psoriasis. The present invention relates to an external preparation for preventing rough skin, which has an effect of improving and preventing rough and rough skin of healthy people, in addition to symptoms.

[0002]

2. Description of the Related Art Conventionally, the effect of improving and preventing skin roughness due to skin diseases such as atopic dermatitis, contact dermatitis, eczema, and psoriasis, and rough and rough skin of healthy persons. As an active ingredient of a skin external preparation having a steroid agent, a steroid agent having an anti-inflammatory effect, vaseline, urea, heparin, various amino acids, and lipids having a moisturizing effect have been used. However, steroids have strong side effects, and moisturizers do not always have sufficient effects, and it has been desired to develop safer and superior active ingredients.

On the other hand, platelet activator (platelet activator) has been used for the development of various inflammatory and allergic skin diseases and rough skin.
ating factor, hereinafter referred to as PAF. ) Is being shown to be involved. For example, in the case of psoriasis, which is an inflammatory dyskeratosis, high PA in the affected epidermis
The presence of F has been recognized. In addition, allergic skin diseases such as atopic dermatitis, contact dermatitis and eczema
The involvement of AF has been suggested. PAF is also considered to play an important role in the normal keratinization process of the epidermis such as keratinization, and attempts have been made to use PAF antagonists as drugs for improving skin roughness or treating skin diseases. It is becoming.

[0004]

[Means for Solving the Problems] In view of such a situation,
The present inventors consider that PAF antagonists are effective in improving various inflammatory and allergic skin diseases and rough and rough skin of healthy persons, and as a result of examining the PAF antagonistic activity of various substances, it was found that (Indonesia name: Temu Kun
ci, scientific name: Boesenbergia pandurata Schl.) extract,
Extract of Kunei Pepet (Kunei pepet, Indonesian name: Kaempferia angustifolia), and Menilan (Indonesia name: Menilan, Scientific name: Phyllanthus n)
iruri L.) extract was found to have strong PAF antagonism. In addition, the present inventors have newly found that the plant extract improves rough skin accompanied by erythema, desquamation, dryness, eczema, itch and the like.

That is, the present invention relates to a ginger family (Zingiberaceae).
aceae) A plant of the genus Zingiber (Temu Kunci, scientific name: Boesenbergia, Indonesian name)
pandurata Schl.) extract, Zingiberac
eae) Kune Pepet, a plant of the genus Kaempferia (Kunei pepet, scientific name: K
aempferia angustifolia) or Euphorbiaceae (Phyllanthus)
A skin external preparation for preventing rough skin and a platelet activating factor antagonist, which comprises, as an active ingredient, an extract of Menilan (Indonesia name: Menilan, scientific name: Phyllanthus niruri L.).

[0006] There has never been reported that the extracts of Temunci, Kney pepet and Menilan have PAF antagonism, and their application to remedies for inflammatory and allergic skin diseases and cosmetics for improving rough skin based on PAF antagonism. Is also not known at all.

Hereinafter, the configuration of the present invention will be described in detail. Temunci, Kunei Pepet and Menilan used in the present invention are used in tropical and southeast Asian countries, especially in Indonesia.
It is a plant that grows in the subtropical region.

[0008] The method for extracting the plant extract used in the present invention is not particularly limited, and raw materials such as roots, rhizomes, stems, leaves, flowers, fruits, etc. of Temunci, Kney pepet and Menilan or whole plants are used as extraction solvents. After immersion, extraction at room temperature or under heating and extraction and filtration, the resulting extract may be used as it is, or may be concentrated or dried under reduced pressure if necessary. Further, these extracts or extracts can be purified using a column or the like and used.

The extraction solvent is not particularly limited. Examples of the extraction solvent include water, primary alcohols such as methyl alcohol and ethyl alcohol, polyhydric alcohols such as 1,3-butylene glycol and propylene glycol, and lower alkyls such as ethyl acetate. A method using a known solvent such as a hydrocarbon such as ester, benzene and hexane, ethyl ether and acetone is used, and these solvents can be used alone or in combination of two or more. Preferred extraction solvents are water, an aqueous solution of ethyl alcohol,
An aqueous solution of 3-butylene glycol is exemplified.

In the present invention, the compounding amount of the extract of Temukunchi, the extract of Kney pepeto and the extract of Meniran is 0.005 to 20.0% by weight, preferably 0.01 to 10. 0% by weight. If the amount is less than 0.005% by weight, the effects of the present invention cannot be sufficiently exerted, and if the amount is more than 20.0% by weight, the effect cannot be substantially increased. It tends to be difficult.

The external preparation for preventing skin roughness according to the present invention can be applied as a PAF antagonist for improving and preventing diseases and symptoms related to PAF, in addition to the agent for preventing skin roughness.

PAF is one of the lipid mediators produced by the action of metabolic enzymes such as phospholipase and acetyltransferase from phospholipids of the cell membrane, and is mainly used in inflammatory cells such as mast cells, neutrophils and monocytes. Produced. P
It has been reported that AF is involved in inflammation and allergic eosinophil migration, production of inflammatory cytokines, cell proliferation / differentiation, and apoptosis.
By antagonistically inhibiting the binding to its receptor, it is effective in ameliorating or preventing diseases and symptoms associated with PAF.

In addition to the above essential components, the skin external preparation of the present invention contains components usually used in skin external preparations such as cosmetics and pharmaceuticals, such as whitening agents, moisturizing agents, antioxidants, oily components, and ultraviolet absorbers. Surfactants, thickeners, alcohols, powder components, coloring materials, aqueous components, water, various skin nutrition agents, and the like can be appropriately compounded as necessary.

In addition, sequestering agents such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, etc., citric acid, glycolic acid, lactic acid, salicylic acid, sodium sulfite, caffeine , Tannin, pantothenic acid and its derivatives, nicotinic acid and its derivatives, tranexamic acid and its derivatives, licorice extract, various plant extracts such as glabridine, malonie, escin, vitamin E derivatives such as vitamin E and tocopherol acetate, glycyrrhizic acid And its derivatives or salts thereof, placenta extract, ascorbic acid and magnesium ascorbate, ascorbic acid derivatives such as ascorbic acid glucoside, arbutin, kojic acid, ellagic acid, chamomile oil, 4-n Whitening agents such as butyl resorcinol, vitamin A derivatives such as vitamin A and retinol, sugars such as glucose, fructose, xylitol, mannose, sucrose, trehalose, humectants such as petrolatum, glycerin, urea, heparin, serine, arginine and the like Various amino acids, ceramides, lipids such as cholesterol and the like can also be appropriately compounded.

The external preparation for skin of the present invention refers to pharmaceuticals, quasi-drugs, and cosmetics, and includes, for example, ointments, creams, emulsions, lotions, packs, bath preparations, etc. as long as they are conventionally used for external preparations for skin. The dosage form is not particularly limited.

[0016]

Next, the present invention will be described in more detail by way of examples. Note that the present invention is not limited to this. The compounding amount is% by weight. Prior to the examples, test methods and results of the plant extract of the present invention relating to PAF antagonism and skin roughness improvement effect will be described.

1. Preparation of Sample (1) Temukunchi Extract 50 g of root and rhizome parts of Temukunchi were immersed in ethanol at room temperature for one week, and the extract was concentrated to obtain 2.5 g of an ethanol extract. In the PAF antagonism test, this solid was dissolved again in dimethyl sulfoxide and dissolved in a 2% solution, 0.1%.
A 2% solution and a 0.02% solution were prepared, and the following experiments were performed using the solutions.

(2) Knee Pepet Extract 50 g of roots and rhizomes of Knee Pepet were immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 2.3 g of an ethanol extract. In the PAF antagonism test, this solid was dissolved again in dimethyl sulfoxide, and a 2% solution was prepared.
A 0.2% solution and a 0.02% solution were prepared, and the following experiments were performed using the solutions.

(3) Meniran extract 50 g of the roots and rhizomes of Meniran were immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 2.2 g of an ethanol extract. In the PAF antagonism test, this solid was dissolved again in dimethyl sulfoxide and dissolved in a 2% solution, 0.1%.
A 2% solution and a 0.02% solution were prepared, and the following experiments were performed using the solutions.

2. PAF antagonism test PAF antagonism was evaluated by its inhibitory effect on platelet aggregation by PAF. Human blood was centrifuged at 1100 rpm for 20 minutes at room temperature to collect platelet-rich plasma (PRP), and then centrifuged at 3000 rpm for 5 minutes to collect platelet-poor plasma (PPP). 223 μL of PRP at 37 ° C.
After pre-warming, 2 μL of a predetermined concentration of a test substance or a solvent was added, and the mixture was further incubated at 37 ° C. for 3 minutes, and then 25 μL of an aggregation-inducing substance PAF was added. The induced aggregation was measured using an aggregometer (MCM Hematracer MCM Medical Co., Ltd.) for 5 minutes, and the maximum aggregation rate at that time was compared with a solvent control group to evaluate the PAF antagonistic activity of the test substance. did. The results are shown in Table 1.

As a reference example, Zingiberaceae (Zingiberaceae) which is a plant already known to be applied to rough skin
aceae) Kuni (Indonesia name: Kunyit, Scientific name: Curcu
ma domestica), Lumpuyan (Zingiberaceae) (Indonesia name: Lempuyang, Scientific name: Zingiber
aromaticum Val.) and an ethanol extract of Hioki sorghum (Isodon japonicus Hara) already known to have a PAF antagonistic effect. Table 1 also shows the results.

[0022]

Table 1 ─────────────────────────────── Test substance Sample concentration PAF-induced platelet aggregation inhibition rate (%) (% ─────────────────────────────── ─────────────────────────────── Temukunchi 0.016 75 0.0016 39 0.00016 16 Kney Pepet 0.016 70 0.0016 29 0.00016 13 Menilan 0.016 80 0.0016 45 0.00016 15 Kuni 0.016 3 Lumpuyan 0.016 0 Hikikoshi 0.016 23 0.0016 0 ───────────────────────────────

3. Skin roughness improvement effect test (1) Actual use test The effect of applying the external preparation of the present invention to the skin
(Erythema / desquamation, dryness, eczema, itching) and improvement rate against razor loss, and skin irritation. Using the faces of 120 female panels suffering from rough skin, of the lotion having the composition (% by weight) shown in Table 2, a sample was applied to one of the left and right cheeks, and a control was applied to the other cheek twice a day for 2 weeks. After application, the skin condition was visually determined. A lotion having the composition shown in Table 2 was applied to 60 male panels who lost the razor immediately after shaving, and the effect on razor losing was determined. Each criterion was as follows.
As the samples of the present invention, two kinds of specimens with different concentrations of the Temunci ethanol extract, two kinds of specimens with different concentrations of Kney pepetoethanol extract, and two kinds of specimens with different concentrations of the Menilan ethanol extract were used. As a comparative product, an ethanol extract of Kuni (Indonesia name: Kunyit, scientific name: Curcuma domestica) of Zingiberaceae, which is a plant already known to be applied to rough skin, and Zingiberaceae (Zingiberaceae) ) Lumpuyang (Indonesia name: Lempuyang, Scientific name: Zingiber ar
omaticum Val.) was used. Table 2 also shows the results.

Judgment Criteria for Improvement Effect on Skin Rough Effective: those with reduced symptoms. Somewhat effective: Somewhat weakened symptoms. Ineffective: No change in symptoms.

Judgment Criteria for Improvement Effect on Razor Loss Significant effect: Loss of razor loss. Effective: Razor loser weakened. Somewhat effective: Razor losing slightly weakened. Invalid: No change in razor loss.

Improvement effect on rough skin and razor losing A: The proportion (effective rate) at which the subject shows remarkably effective, effective and slightly effective (effective rate) is 80% or more. ：: The proportion (effective rate) at which the test subject shows a remarkable effect, an effective effect and a somewhat effective effect is 50% or more and less than 80%. Δ: The ratio (effective rate) at which the test subject showed remarkable, effective, and somewhat effective (effective rate) was 30% or more and less than 50%. ×: The ratio (effective rate) at which the subject exhibited significant, effective, and somewhat effective (effective rate) was less than 30%.

Skin irritation ◎: 0% of subjects had a burning sensation on the skin. ：: The proportion of subjects who felt tingling on the skin was less than 5%. Δ: The ratio of subjects who felt burning on the skin was less than 10%. ×: The proportion of subjects who felt burning on the skin was 10% or more.

[0028]

[Table 2] ────────────────────────────────── Sample of the present invention Comparative sample ───── {1 2 3 4 5 6 1 2} ─────── Temukunchi extract 1.0 0.2 − − − − − − Kney pepeto extract − − 1.0 0.2 − − − − Menilan extract − − − − 1.0 0.2 − − Kuni extract − − − − − − 1.0 − Lumpuyan extract − − − − − − − − 1.0 Glycerin 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 1,3-butylene glycol 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 Ethanol 7.0 7.0 7.0 7.0 7.0 7.0 7.0 7.0 Polyoxyethylene ( (20 mol) Oleyl alcohol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Purified water Residue Residue Residue Residue Residue Residue Residue ────────────効果 Skin roughness improvement effect ◎ ○ ◎ ○ ◎ ○ △ △ Razor losing prevention effect ◎ ○ ◎ ○ ◎ ○ △ △ Skin irritation ◎ ◎ ◎ ◎ ◎ ◎ ◎ ○ △ ──────────────────────────────────

As is clear from Table 2, the sample of the present invention containing the extract of Temunci, the extract of Kney pepeto and the extract of Menilan was superior to the sample of the comparative product in the improvement of rough skin and razor loss. The effect was shown, and no skin irritation was observed.

(2) Actual use test by replica method Using lotions of the present invention products 1 to 6 and comparative products 1 and 2,
A skin roughness improvement effect test was performed using a human body panel. That is, a replica of the skin surface of a healthy female person (face) was taken using a replica method and observed with a microscope (17 ×). The skin roughness evaluation was determined to be 1, 2, 3, or 4 based on the criteria shown in Table 3 from the state of the skin pattern and the peeled state of the stratum corneum (rough skin panel). Lotions of the present invention products 1 to 6 and comparative products 1 and 2 twice a day,
It was applied for two weeks. Two weeks later, the skin condition was observed again according to the replica method described above, and evaluated according to the criteria shown in Table 3. Table 4 shows the results.

[0031]

[Table 3] 点 Scoring criteria for scoring ──────── １ 1 Skin sulcus, skin ridges disappeared, and widespread stratum corneum was observed. 2 Skin sulcus and skin ridges are unclear and horny layer is turned up. 3 Skin sulcus and skin ridge are recognized, but flat. 4 Skin sulcus and skin hills are clear. 5 Skin sulcus and skin hills are clear and well-organized. ────────────────────────────────

[0032]

[Table 4] ────────────────────────────────── Inventive product Comparative product Replica evaluation ───── ─────────── ─────── 1 2 3 4 5 6 1 2 ──────────────────────── ────────── 100 000 000 001 000 000 000 000 004 5 3 7 7 11 7 10 6 10 13 11 4 9 7 9 9 10 10 9 2 4 5 4 4 4 4 1 410 ──────────────────────────────────

As can be seen from Table 4, the lotion of the product of the present invention showed a remarkable effect of improving rough skin as compared with the lotion of the comparative product.

Example 1 Cream (Formulation) Stearic acid 5.0% by weight Stearyl alcohol 4.0 Isopropyl myristate 18.0 Glycerin monostearate 3.0 Propylene glycol 10.0 Temukunchi ethanol extract 0.01 Caustic potassium 0 .2 Sodium bisulfite 0.01 Preservatives Appropriate amount Fragrance Appropriate amount Ion-exchanged water Residue (Preparation method) Add propylene glycol, Temunci ethanol extract and caustic potash to ion-exchanged water, dissolve and heat to 70 ° C (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). Add the oil phase gradually to the water phase,
After all the ingredients have been added, the temperature is maintained for a while to cause a reaction. Thereafter, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well.

Example 2 Cream (Formulation) Stearic acid 2.0% by weight Stearyl alcohol 7.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol) Cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 Temmunci Ethanol extract 0.05 Sodium bisulfite 0.03 Ethylparaben 0.3 Perfume Appropriate amount Ion-exchange water Residue (Production method) Propylene glycol in ion-exchange water In addition,
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, pre-emulsified, homogenized with a homomixer, and cooled to 30 ° C. with good stirring.

Example 3 Cream (Formulation) Solid paraffin 5.0% by weight Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) Sorbitan monolaurate 2 0.0 Soap powder 0.1 Borax 0.2 Kney pepeto Ethanol extract 0.05 Tecumunci Ethanol extract 0.05 Sodium bisulfite 0.03 Ethyl paraben 0.3 Perfume Appropriate amount Ion exchange water Residue (Production method) Ion exchange water Soap powder and borax are added to the mixture, and the mixture is dissolved by heating and maintained at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the aqueous phase while stirring to carry out the reaction. After completion of the reaction, the mixture is uniformly emulsified with a homomixer, and cooled to 30 ° C. while stirring well after emulsification.

Example 4 Emulsion (Formulation) 2.5% by weight of stearic acid Cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) Monooleate 2.0 Polyethylene glycol 1500 0 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 (trade name: Carbopol 941, BFGoodrich Chemical company) Kney pepeto ethyl acetate extract 0.01 Sodium bisulfite 0.01 Ethyl paraben 0.3 Fragrance Appropriate ion Exchange water residue (Preparation method) Dissolve the carboxyvinyl polymer in a small amount of ion exchange water (phase A). Polyethylene glycol 1500 and triethanolamine are added to the remaining ion-exchanged water, dissolved by heating, and kept at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase to perform preliminary emulsification, the phase A is added, and the mixture is uniformly emulsified with a homomixer. After the emulsification, the mixture is cooled to 30 ° C. while stirring well.

Example 5 Emulsion (Formulation) Microcrystalline wax 1.0% by weight Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) ) Sorbitan monooleate 1.0 Propylene glycol 7.0 Tecumunci Acetone extract 10.0 Sodium bisulfite 0.01 Ethyl paraben 0.3 Perfume Appropriate amount Ion-exchanged water Residue (Production method) Add propylene glycol to ion-exchanged water.
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added thereto, and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C with good stirring.

Example 6 Jelly (Formulation) 95% ethyl alcohol 10.0% by weight Dipropylene glycol 15.0 Polyoxyethylene (50 mol) Oleyl alcohol ether 2.0 Carboxyvinyl polymer 1.0 (trade name: Carbopol) 940, BFGoodrich Chemical company) Caustic soda 0.15 L-arginine 0.1 Temmunci 50% aqueous ethanol extract 7.0 Sodium 2-hydroxy-4-methoxybenzophenonesulfonate 0.05 Ethylenediaminetetraacetate 3 Sodium 2 water 0 0.05 Methyl paraben 0.2 Perfume Appropriate amount Ion-exchanged water Residue (Preparation method) Carbopol 940 is uniformly dissolved in ion-exchanged water, while temcunch 50% ethanol aqueous solution extract in 95% ethanol, polyoxyethylene (50 mol) Dissolve the rail alcohol ether and add to the aqueous phase. Then, after adding other components, caustic soda,
Neutralize with L-arginine to thicken.

Example 7 Serum (Prescription) (Phase A) Ethyl alcohol (95%) 10.0% by weight Polyoxyethylene (20 mol) Octyldodecanol 1.0 Pantothenyl ethyl ether 0.1 Kney pepeto ethanol Extract 1.5 Methylparaben 0.15 (Phase B) Potassium hydroxide 0.1 (Phase C) Glycerin 5.0 Dipropylene glycol 10.0 Sodium bisulfite 0.03 Carboxyvinyl polymer 0.2 (Product name: Carbo Pall 940, BFGoodrich Chemical company) Purified water residue (Preparation method) Dissolve A phase and C phase uniformly, and add A to C phase
Add phases and solubilize. Next, after adding the phase B, filling is performed.

Example 8 Pack (Formulation) (Phase A) Dipropylene glycol 5.0% by weight Polyoxyethylene (60 mol) Hardened castor oil 5.0 (Phase B) Temukunchi ethanol extract 0.01 Olive oil 5.0 Tocopherol acetate 0.2 Ethylparaben 0.2 Fragrance 0.2 (Phase C) Sodium bisulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, Degree of polymerization 2,000) Ethanol 7.0 Purified water residue (Production method) ) A phase, B phase and C phase are each dissolved uniformly,
Add phase B to phase and solubilize. Next, this is added to the C phase and then filled.

Example 9 Solid foundation (formulation) Talc 43.1% by weight Kaolin 15.0 Sericite 10.0 Zinc white 7.0 Titanium dioxide 3.8 Yellow iron oxide 2.9 Black iron oxide 0.2 Squalane 8 0.0 Isostearic acid 4.0 POE sorbitan monooleate 3.0 Isocetyl octanoate 2.0 Tecumunci Ethanol extract 0.5 Preservatives Appropriate amount Flavors Appropriate amount (Production method) Powdery components of talc to black iron oxide are sufficiently mixed in a blender. Squalane-isocetyl octanoate oil component, temkunchi ethanol extract, preservative,
After adding fragrance and kneading well, the mixture is filled into a container and molded.

Example 10 Emulsion type foundation (cream type) (prescription) (powder part) Titanium dioxide 10.3% by weight Sericite 5.4 Kaolin 3.0 Yellow iron oxide 0.8 Bengala 0.3 Black iron oxide 0.2 (oil phase) Decamethylcyclopentasiloxane 11.5 Liquid paraffin 4.5 Polyoxyethylene-modified dimethylpolysiloxane 4.0 (aqueous phase) Purified water 50.0 1,3-butylene glycol 4.5 Temukunchi Ethanol extract 0.5 Kney pepeto Ethanol extract 0.5 Sorbitan sesquioleate 3.0 Preservatives Appropriate amount Flavors Appropriate amount (Production method) Treat with a homomixer. Further, the oil phase mixed by heating is added, and the mixture is treated with a homomixer. Then, a fragrance is added with stirring, and the mixture is cooled to room temperature.

Example 11 Cream (Formulation) Stearic Acid 5.0% by Weight Stearyl Alcohol 4.0 Isopropyl Myristate 18.0 Glycerin Monostearate 3.0 Propylene Glycol 10.0 Menirane Ethanol Extract 0.01 Caustic Potassium 0 .2 Sodium bisulfite 0.01 Preservatives Appropriate amount Fragrance Appropriate amount Ion-exchange water Residue (Preparation method) Add propylene glycol, menilan ethanol extract and caustic potash to ion-exchange water, dissolve and heat to 70 ° C (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause a reaction. Thereafter, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well.

Example 12 Cream (Formulation) Stearic Acid 2.0% by Weight Stearyl Alcohol 7.0 Hydrogenated Lanolin 2.0 Squalane 5.0 2-Octyldodecyl Alcohol 6.0 Polyoxyethylene (25 mol) Cetyl Alcohol Ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 Menirane Ethanol extract 0.05 Sodium bisulfite 0.03 Ethylparaben 0.3 Perfume Appropriate amount Ion-exchanged water Residue (Production method) Propylene glycol in ion-exchanged water In addition,
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, pre-emulsified, homogenized with a homomixer, and cooled to 30 ° C. with good stirring.

Example 13 Cream (Formulation) Solid paraffin 5.0% by weight Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) Sorbitan monolaurate 2 0.0 Soap powder 0.1 Borax 0.2 Menilan acetone extract 0.05 Menilan ethanol extract 0.05 Sodium bisulfite 0.03 Ethylparaben 0.3 Perfume Appropriate amount Ion-exchange water Residue (Production method) Soap in ion-exchange water Add powder and borax, heat and dissolve and maintain at 70 ° C (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the aqueous phase while stirring to carry out the reaction. After completion of the reaction, the mixture is uniformly emulsified with a homomixer, and cooled to 30 ° C. while stirring well after emulsification.

Example 14 Emulsion (Formulation) 2.5% by weight of stearic acid Cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) Monooleate 2.0 Polyethylene glycol 1500 0 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 (Product name: Carbopol 941, BFGoodrich Chemical company) Menilan acetate ethyl ester extract 0.01 Sodium bisulfite 0.01 Ethyl paraben 0.3 Fragrance Appropriate amount Ion exchange water Residue (Preparation method) Dissolve the carboxyvinyl polymer in a small amount of ion-exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine are added to the remaining ion-exchanged water, dissolved by heating, and kept at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase to perform preliminary emulsification, the phase A is added, and the mixture is uniformly emulsified with a homomixer. After the emulsification, the mixture is cooled to 30 ° C. while stirring well.

Example 15 Emulsion (Formulation) Microcrystalline wax 1.0% by weight Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) ) Sorbitan monooleate 1.0 Propylene glycol 7.0 Menirane Acetone extract 10.0 Sodium bisulfite 0.01 Ethyl paraben 0.3 Perfume Appropriate amount Ion-exchanged water Residue (Production method) Add propylene glycol to ion-exchanged water.
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added thereto, and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C with good stirring.

Example 16 Jelly (Formulation) 95% ethyl alcohol 10.0% by weight Dipropylene glycol 15.0 Polyoxyethylene (50 mol) Oleyl alcohol ether 2.0 Carboxyvinyl polymer 1.0 (Product name: Carbopol) 940, BFGoodrich Chemical company) Caustic soda 0.15 L-arginine 0.1 Menirane 50% aqueous ethanol extract 7.0 Sodium 2-hydroxy-4-methoxybenzophenonesulfonate 0.05 Ethylenediaminetetraacetate 3 Sodium 2 water 0.05 Methylparaben 0.2 Perfume Appropriate amount Ion-exchanged water Residue (Preparation method) Carbopol 940 is uniformly dissolved in ion-exchanged water, while menilan 50% ethanol aqueous solution extract in 95% ethanol, polyoxyethylene (50 mol)
Dissolve the oleyl alcohol ether and add to the aqueous phase. Then, after adding other components, caustic soda, L
-Neutralize with arginine to thicken.

Example 17 Serum (Prescription) (Phase A) Ethyl alcohol (95%) 10.0% by weight Polyoxyethylene (20 mol) Octyldodecanol 1.0 Pantothenyl ethyl ether 0.1 Menirane Ethanol extract 1.5 Methylparaben 0.15 (B phase) Potassium hydroxide 0.1 (C phase) Glycerin 5.0 Dipropylene glycol 10.0 Sodium bisulfite 0.03 Carboxyvinyl polymer 0.2 (Product name: Carbopol 940) BF Goodrich Chemical company) Purified water Residue (Preparation method) Dissolve A phase and C phase uniformly, and add A to C phase
Add phases and solubilize. Next, after adding the phase B, filling is performed.

Example 18 Pack (Formulation) (A phase) Dipropylene glycol 5.0% by weight Polyoxyethylene (60 mol) hydrogenated castor oil 5.0 (B phase) Menilan ethanol extract 0.01 Olive oil 5.0 Tocopherol acetate 0.2 Ethylparaben 0.2 Fragrance 0.2 (Phase C) Sodium bisulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, Degree of polymerization 2,000) Ethanol 7.0 Purified water residue (Production method) ) A phase, B phase and C phase are each dissolved uniformly,
Add phase B to phase and solubilize. Next, this is added to the C phase and then filled.

Example 19 Solid Foundation (Formulation) Talc 43.1 wt% Kaolin 15.0 Sericite 10.0 Zinc White 7.0 Titanium Dioxide 3.8 Yellow Iron Oxide 2.9 Black Iron Oxide 0.2 Squalane 8 2.0 Isostearic acid 4.0 POE sorbitan monooleate 3.0 Isocetyl octoate 2.0 Menilan Ethanol extract 0.5 Preservatives Appropriate amount Fragrance Appropriate amount (Preparation method) Powdery components of talc to black iron oxide are sufficiently mixed in a blender. Then, the oily components of squalane to isocetyl octanoate, menilane ethanol extract, preservatives, and fragrances are added, kneaded well, and the mixture is filled into a container and molded.

Example 20 Emulsion Type Foundation (Cream Type) (Prescription) (Powder Part) Titanium Dioxide 10.3% by Weight Sericite 5.4 Kaolin 3.0 Yellow Iron Oxide 0.8 Bengala 0.3 Black Iron Oxide 0.2 (oil phase) Decamethylcyclopentasiloxane 11.5 Liquid paraffin 4.5 Polyoxyethylene-modified dimethylpolysiloxane 4.0 (aqueous phase) Purified water 50.0 1,3-butylene glycol 4.5 Menirane Ethanol extract 1.5 Sorbitan sesquioleate 3.0 Preservatives Appropriate amount Flavors Appropriate amount (Preparation method) After heating and stirring the aqueous phase, a well-mixed and pulverized powder portion is added, followed by homomixer treatment. Further, the oil phase mixed by heating is added, and the mixture is treated with a homomixer. Then, a fragrance is added with stirring, and the mixture is cooled to room temperature.

[0054]

As described above, the skin external preparation for preventing rough skin according to the present invention is excellent in PAF antagonism, and has excellent effects in improving and preventing various skin diseases, rough skin, roughness and the like. It is also excellent in safety.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 U 35/78 35/78 A L A61P 17/06 A61P 17/06 17 / 16 17/16 29/00 29/00 37/08 37/08 43/00 111 43/00 111 F term (reference) 4C083 AA082 AA111 AA112 AA122 AB032 AB152 AB212 AB232 AB242 AB352 AB432 AC012 AC022 AC072 AC102 AC122 AC182 AC242 AC262 AC352 AC352 AC422 AC442 AC472 AC482 AC532 AC542 AC582 AC642 AC792 AD041 AD092 AD112 AD162 AD172 AD512 AD662 BB49 CC02 CC04 CC05 CC07 DD08 DD23 DD31 DD41 EE01 EE13 4C088 AB46 AB81 AC01 AC03 AC04 AC05 AC11 AC12 BA08 CA14 MA63 NA14 ZA89 ZB90 Z48

Claims (2)

[Claims] 1. A plant of the genus Zingiberaceae (Zingiberaceae), Temu Kunci (Indonesia name: Temu Kunci, scientific name: Boesenbergia pandurata Sch)
l.), a plant of the genus Zingiberaceae, Kaempferia (Kempei pepet, scientific name: Kaempferia an
gustifolia) or Euphorbiaceae (Euphor)
biaceae) A plant of the genus Phyllanthus, Indonesian name: Menilan, scientific name: Phyllanth
us niruri L.) extract as an active ingredient. 2. A plant belonging to the genus Zingiberaceae (Zingiber), Temukunci (Indonesia name: Temu Kunci, scientific name: Boesenbergia pandurata Sch)
l.), a plant of the genus Zingiberaceae, Kaempferia (Kempei pepet, scientific name: Kaempferia an
gustifolia) or Euphorbiaceae (Euphor)
biaceae) A plant of the genus Phyllanthus, Indonesian name: Menilan, scientific name: Phyllanth
us niruri L.) extract as an active ingredient, and a platelet activating factor (platelet activating factor).
factor, PAF) antagonist.