JP2001131041A - Composition for oral use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for oral use having high preservation stability even though it is blended with an apatite. SOLUTION: This composition for oral use contains at least one species selected from a group consisting of hydroxyapatite, fluoroapatite, apatite carbonate, calcium tertiary phosphate, calcium quaternary phosphate and calcium octavus phosphate and characterized in that it further contains 0.05-10 mass % of at least one species of magnesium salts based on the whole mass of the composition for oral use.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an oral composition having excellent storage stability.

[0002]

2. Description of the Related Art It has been known that an apatite such as hydroxyapatite is blended with an oral composition such as toothpaste to impart an effect of remineralizing teeth and adsorbing and removing plaque. . However, toothpastes containing apatite such as hydroxyapatite tend to be hard, have a rough appearance over time, and have a problem that sufficient storage stability cannot be obtained, such as liquid separation. Therefore, it is desired to ensure stability when apatite is blended.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide an oral composition containing apatites and having high storage stability.

[0004]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to solve the above-mentioned problems, and as a result, by combining a magnesium salt with an oral composition containing apatite, a high temperature is obtained. It has been found that a stable oral composition which does not become hard even when stored for a long period of time, maintains the smoothness in appearance, and does not cause liquid separation, has completed the present invention. Therefore, the present invention
An oral composition comprising at least one selected from the group consisting of hydroxyapatite, fluoroapatite, carbonate apatite, tribasic calcium phosphate, quaternary calcium phosphate, and octacalcium phosphate, wherein at least one magnesium salt contains at least one magnesium salt. The present invention relates to an oral composition characterized by containing 0.05 to 10% by mass based on the total mass of the product.

[0005]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail. As used herein, the oral composition includes toothpastes, dentifrices such as liquid dentifrice, troches, creams, ointments,
Includes attachments, mouthwash, mouthwash, mouthwash, chewing gum or gargle. The apatite used in the present invention means hydroxyapatite, fluoroapatite, carbonate apatite, tribasic calcium phosphate, quaternary calcium phosphate and calcium octaphosphate.
In the present specification, hydroxyapatite, fluoroapatite, carbonate apatite, tribasic calcium phosphate, calcium tetraphosphate and calcium octaphosphate are collectively referred to as apatites. Apatites are represented by the following chemical formulas. Hydroxyapatite: Ca ₁₀ (PO ₄ ) ₆ (OH) ₂ Fluoroapatite: Ca ₁₀ (PO ₄ ) ₆ F ₂ Carbonate apatite: CO ₃ Ap Calcium phosphate tribasic: Ca ₃ (PO ₄ ) ₂ Quaternary calcium phosphate: Ca ₄ O (PO _{4) 2} eighth calcium phosphate: at _{Ca 8 (PO 4) 6 ·} 5H 2 O among these, hydroxyapatite and tricalcium phosphate are preferably used.

[0006] These apatites are the main components (inorganic components) of teeth and bones, and are highly safe materials with excellent biocompatibility. For this reason, hydroxyapatite, tribasic calcium phosphate, and the like are used as biomaterials in artificial joints, artificial roots, and the like. In addition, it is known that the positions of calcium ions, phosphate ions, and hydroxyl ions in hydroxyapatite are replaced with various trace elements. When carbonate ions are taken in, it becomes carbonate apatite. Synthetic products are generally used for apatites, and such commercially available synthetic products can also be used in the present invention. These are not particularly limited, but are supplied in the form of a white aqueous suspension or powder, and have an average particle size of 1 to 70 μm.
Hydroxyapatite in the oral composition of the present invention,
Fluorapatite, carbonate apatite, tricalcium phosphate, at least one content selected from the group consisting of quaternary calcium phosphate and octacalcium phosphate,
The amount is suitably from 0.1 to 50% by mass, preferably from 1 to 30% by mass, based on the total mass of the oral composition. This amount
Recalcification of the tooth surface, which is expected to be less than 0.1% by mass,
The effect of removing and removing plaque is not exhibited. On the other hand, if it exceeds 50% by mass, the effect corresponding to the content cannot be obtained, and the usability may be impaired.

As the magnesium salt used in the present invention, at least one selected from magnesium pyrophosphate, dibasic magnesium phosphate and tribasic magnesium phosphate can be used. Magnesium salts are used for the purpose of suppressing the conversion of calcium hydrogen phosphate to hydroxyapatite blended in foods, dentifrices, and the like, and some are commercially available. In the present invention, these commercially available products can be used. The content of magnesium salt with respect to the total mass of the oral composition is 0.05.
10 to 10% by mass, preferably 0.1 to 5% by mass. If the amount is less than 0.05% by mass, the expected effect is not exhibited. If the amount exceeds 10% by mass, the effect corresponding to the content cannot be obtained, and the usability may be impaired.

[0008] In addition to the above components, the following components can be added to the oral composition of the present invention, if necessary, within the usual use amount, depending on the type. <Abrasives> Silica gel, precipitated silica, igneous silica,
Silica-based abrasives such as aluminosilicate, zirconosilicate, silicic anhydride, hydrous silicic acid, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrous, calcium pyrophosphate, aluminum hydroxide, alumina, light calcium carbonate, heavy Examples include calcium carbonate, magnesium carbonate, zirconium silicate, and synthetic resin-based abrasives, and one or more of these can be used in combination. The amount of the abrasive is preferably 3 to 60% by mass, more preferably 10 to 60% by mass, based on the whole composition.
~ 45% by mass.

<Wetting agent> One or two kinds of polyhydric alcohols such as glycerin, concentrated glycerin, diglycerin, sorbitol, maltitol, dipropylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol and xylitol. The above can be used. <Binder> carrageenan (ι, λ, κ), alginic acid,
Alginates such as sodium alginate, propylene glycol alginate, sodium alginate containing calcium, potassium alginate, calcium alginate, ammonium alginate and derivatives thereof, polyvinylpyrrolidone, xanthan gum, guar gum, gelatin, agar, sodium carboxymethylcellulose, hydroxyethylcellulose, polyacrylic acid Sodium and the like, and one or more of these can be used in combination.

<Foaming agent> Sodium lauryl sulfate, sodium lauroyl sarcosine, sodium alkyl sulfosuccinate, sodium coconut fatty acid monoglycerin sulfonate, sodium α-olefin sulfonate, N-
N-acyl amino acid salts such as acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, maltitol fatty acid ester, sucrose fatty acid ester, polyglycerin fatty acid ester, fatty acid diethanolamide, polyoxyethylene Sorbitan monostearate, polyoxyethylene hydrogenated castor oil,
Examples thereof include polyoxyethylene fatty acid esters, and one or more of these can be used in combination.

<Sweetening agents> Saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartin and the like. <Preservatives> Parabens such as methylparaben, ethylparaben, propylparaben, and butylparaben, sodium benzoate, phenoxyethanol, and alkyldiaminoethylglycine hydrochloride.

<Fragrance ingredients> l-menthol, anethole,
One or more of menthone, cineole, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, thymol, cinamic aldehyde, trans-2-hexenal and the like can be used in combination. These components may be compounded individually,
Essential oils containing these may be blended. Further, in addition to the above flavor components, aliphatic alcohols and esters thereof, terpene hydrocarbons, phenol ethers, aldehydes,
Perfume components such as ketones and lactones, and essential oils may be blended as long as the effects of the present invention are not impaired. The amount of the above fragrance is
The content is preferably set to 0.02 to 2% by mass based on the whole composition.

<Active ingredient> Lysozyme chloride, monofluorophosphate, sodium fluoride, potassium fluoride,
Hinokitiol, ascorbic acid, chlorhexidine salts, triclosan, isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, bisabolol, tocopherol acetate, ε
One or two of aminocaproic acid, tranexamic acid, aluminum hydroxyl allantoin, aluminum lactate, dihydrocholesterol, glycyrrhetinic acid, glycyrrhizinates, copper chlorophyllin salt, sodium chloride, guaiazulene sulfonate, dextranase, pyridoxine hydrochloride, etc. More than one species can be blended.

<Others> Pigments such as Blue No. 1, pigments such as titanium oxide, antioxidants such as dibutylhydroxytoluene, chelating agents such as edetate, tea extract, tea distillation, propolis extract, and sodium glutamate. Agents and the like.

The oral composition of the present invention can be produced according to a conventional method, and the production method is not particularly limited. Further, the obtained composition such as a toothpaste can be used after being filled in an aluminum tube, a laminate tube, a glass deposition tube, a plastic tube, a plastic bottle, an aerosol container and the like.

[0016]

EFFECTS OF THE INVENTION The oral composition of the present invention is capable of preventing changes over time such as hardening, coarsening, and liquid separation, which are conventionally observed in oral compositions containing apatites. While exhibiting excellent storage stability.

[0017]

EXAMPLES The present invention will be described in detail below with reference to experimental examples and examples, but the present invention is not limited to the following examples. In addition,% shown in the following examples means mass%. <Stability test> Various toothpastes were prepared according to the conventional method using the formulations (unit: mass%) shown in Table 1, filled in an aluminum tube, and stored at 50 ° C for 2 months. These preserved products were subjected to a sensory evaluation of hardness, roughness (smoothness) and liquid separation based on the following evaluation criteria.
Table 2 shows the results.

[Evaluation Criteria] 1) Hardness: Tactile evaluation of the ease of extrusion from the tube. ◎ ・ ・ ・ ・ ・ Soft and very easy to put out. ○ ・ ・ ・ ・ ・ ・ ・ It is easy to put out with normal hardness. △ ・ ・ ・ ・ ・ ・ ・ Slightly hard and slightly hard to put out. ×: It is hard and very hard to put out. 2) Roughness: Visually evaluate the appearance of the contents extruded from the tube. A: Very smooth and glossy. ○ ・ ・ ・ ・ ・ ・ ・ Smooth and slightly glossy. △ ・ ・ ・ ・ ・ Slightly rough, almost no gloss. ×: There is no gloss at all. 3) Liquid separation: Liquid separation from toothpaste is visually evaluated. ○ ・ ・ ・ ・ ・ Almost no separation. △ ・ ・ ・ ・ ・ ・ ・ Slightly separated. ×: It is clearly separated.

[0019]

[Table 1]

[0020]

[Table 2]

From the above experimental results, it can be seen that the toothpaste according to the present invention has excellent stability over time. In addition, when the above-mentioned experiments were carried out also for the toothpastes of Examples 5 to 20 shown below, all the same results were obtained. Hereinafter, the compositions of the toothpastes of Examples 5 to 20 are shown. The unit of the compounding amount is mass%.

[0022]

Embodiment 5

[0023]

Example 6 Hydroxyapatite 5.0 Magnesium tertiary phosphate 0.5 Aluminum hydroxide 35.0 Silicic anhydride 5.0 Concentrated glycerin 25.0 Carrageenan 0.5 Sodium carboxymethyl cellulose 0.5 Sodium lauryl sulfate 1. 5 Stevia extract 0.1 Ethylparaben 0.1 Cetylpyridium chloride 0.05 Perfume 1.0 Water Balance 100.0

[0024]

Example 7 Hydroxyapatite 10.0 Magnesium tertiary phosphate 0.5 Heavy carbonic acid 30.0 Silicic anhydride 7.0 Propylene glycol 15.0 Sorbit 15.0 Sodium carboxymethyl cellulose 0.6 Sodium polyacrylate 0 .6 Sodium lauryl sulfate 1.5 Saccharin sodium 0.05 Alkyl diaminoethyl glycine hydrochloride 0.05 Beta-glycyrrhetinic acid 0.05 Coctylhexidine hydrochloride 0.02 Fragrance 1.0 Water Residue 100.0

[0025]

Example 8 Carbonate Apatite 20.0 Magnesium Tertiary Phosphate 0.1 Calcium Pyrophosphate 30.0 Silicic Anhydride 7.0 Concentrated Glycerin 25.0 Carrageenan 0.5 Sodium Carboxymethyl Cellulose 0.5 Polyoxyethylene Hydrogenated Castor Oil 3.0 Sodium lauryl sulfate 1.5 Stevia extract 0.1 Propyl paraben 0.1 Lysozyme chloride 0.4 ε-Aminocaproic acid 0.1 Perfume 1.0 Water Balance 100.0

[0026]

Embodiment 9

[0027]

Embodiment 10

[0028]

Embodiment 11

[0029]

Example 12 Calcium quaternary phosphate 20.0 Magnesium tertiary phosphate 10.0 Aluminum hydroxide 15.0 Silicic anhydride 5.0 Concentrated glycerin 20.0 Xylitol 10.0 Sodium carboxymethyl cellulose 1.0 Sodium lauryl sulfate 0 2.5 2-Alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine 3.0 Stevia extract 0.1 Ethylparaben 0.1 Fragrance 1.0 Aluminum lactate 1.0 Water Balance 100.0

[0030]

Embodiment 13

[0031]

Embodiment 14

[0032]

Embodiment 15

[0033]

Embodiment 16

[0034]

Embodiment 17

[0035]

Embodiment 18

[0036]

Embodiment 19

[0037]

Embodiment 20

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/28 A61K 7/28 (72) Inventor Yoshikazu Ishii 2-216-3 Minami-Osawa, Hachioji-shi, Tokyo Mitsuwa Crest 206 F term (reference) 4C083 AA112 AB222 AB291 AB292 AB321 AB322 AB372 AB472 AC122 AC132 AC302 AC432 AC472 AC482 AC582 AC622 AC662 AC692 AC712 AC742 AC782 AC792 AC812 AC862 AD092 AD212 AD272 AD352 AD472 AD532 AD662 CC41 DD22

Claims (1)

[Claims] 1. An oral composition containing at least one selected from the group consisting of hydroxyapatite, fluorapatite, carbonate apatite, tricalcium phosphate, tetraquat calcium phosphate and calcium octaphosphate, wherein at least one magnesium An oral composition comprising 0.05 to 10% by mass of a salt based on the total mass of the oral composition.