JP2001190689A - Flow passage changeover valve for dosing liquid medicine, liquid medicine encapsulating body, and cartridge body for dosing liquid medicine - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a flow passage changeover valve which supplies two kinds of liquids through different routes, a highly safe and convenient liquid medicine encapsulating body, and a cartridge body for dosing liquid medicine which can be handled easily at a medical job site. SOLUTION: The flow passage changeover valve has a starting -end stop-cock section having one inlet port and two outlet ports and a transmitting-end stop- cock section having two inlet ports and one outlet port. The liquid medicine encapsulating body has connecting ports which can be connected to the outlet port of the starting-end stop-cock section and the inlet port of the terminating end stop-cock section. The cartridge for dosing liquid medicine is constituted by connecting the liquid medicine encapsulating body to the flow passage changeover valve.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid medicine flow path switching valve, a liquid medicine enclosure, and a liquid medicine administration cartridge.

[0002]

2. Description of the Related Art As a container for containing a liquid chemical,
Currently, ampules, glass vials, syringes and the like are widely used. Thus, in the case of a medicinal solution filled in a general ampoule or glass vial, the medicinal solution is once refilled in a syringe or an infusion bag, and then used for administration. Usually, it is directly used for administration.

However, for example, when a bolus dose of a radiopharmaceutical or the like pre-filled in a syringe is administered directly in the following procedure without directly administering it. . That is, as shown in FIG. 15, for example, a three-way cock 100 with a needle, an extension tape 101, a winged needle 103 with a tube 102, and the like are sequentially connected to form an administration route. Next, after connecting the injection cylinder 104 filled with physiological saline to one entry port of the three-way cock 100 of the administration route, a part of the internal physiological saline is pushed out by the plunger rod 104a, and the administration route 100 , 101, 102, and 103 are expelled. Next, the blood vessel of the patient is secured by the winged needle 103 at the end of the administration route. Next, after connecting the injection tube 105 with a radiation shielding material filled with a radioactive agent in advance to the other entrance port of the three-way cock 100, the flow path of the three-way cock 100 is switched, and the inside of the three-way cock 100 is switched by the plunger rod 105a. The radiopharmaceutical is extruded, and the radiopharmaceutical is temporarily held in the administration route, particularly in the extension tape 101. Next, the three-way stopcock 100 flow path is returned to its original state, and the physiological saline is again pushed into the administration route from the syringe 104 filled with the physiological saline to rapidly administer the radiopharmaceutical retained in the administration route into the blood vessel. I do.

[0004] However, such a bolus administration of a drug solution is performed by using the same administration route, particularly one extension tube, for both degassing with a physiological saline and administration of the drug solution. Two push syringes, one for a saline solution and one for a drug solution, which can be attached to a rod, have been required.

[0005] As a result, from the viewpoint of simplicity of handling at the medical site, even a form in which a drug solution is filled in a container in advance and supplied to the market has to be a so-called pre-fill syringe of a syringe type. In fact, the form was not considered.

[0006] In the case of a prefilled syringe, an exposed needle for penetrating into the syringe is separately required, which may cause a needle stick accident. In particular, when the drug solution is a radiopharmaceutical, the syringe is held in an extension tube. There was a problem that could not be overlooked that radiation exposure from the chemical solution inside was unavoidable.

[0007] As described above, in the first place, various equipment such as a three-way cock and an extension tube must be prepared at the medical site, and the connecting operation of these must be performed. In addition, there was a problem that a considerable amount of complicated preparatory actions were required, and the risk of virus and germ contamination was unavoidable when connecting the devices. Also, the switching operation of the three-way stopcock was required twice because the same route was shared.

Further, even in the case of the simple direct administration method described above, when the medical solution is a radiopharmaceutical, a radiation shielding material is required, so that the medical solution injection barrel naturally becomes considerably heavy. It is difficult to secure a blood vessel to be administered, and sometimes it takes time to administer the drug, or a mistake such as a part of the drug solution is administered extravascularly.

[0009]

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned conventional problems, and has been made in consideration of the above-mentioned problems. The purpose is to provide.

[0010] Another object of the present invention is to provide a novel liquid medicine enclosure that is more safe and convenient than a prefilled syringe.

Still another object of the present invention is to provide a cartridge for administration of a drug solution which is excellent in ease of handling and safety in a medical field.

[0012]

SUMMARY OF THE INVENTION The present invention provides a start stopcock having one entrance port and two subsequent exit ports that can be selectively switched, and two entrance ports that can be selectively switched. The above object has been attained by a flow path switching valve for medicinal solution administration, which has a stopcock provided with a single outlet port and a subsequent stop port.

Further, according to the present invention, a start-end connection port which can be connected to and opened from the second outlet port of the start-end cock portion of the above-mentioned drug solution administration flow path switching valve, and can be connected to and opened from the second entry port of the end cock portion. The above object has been achieved by a liquid medicine enclosure having a simple terminal connection port.

Further, the present invention has achieved the above-mentioned object by a drug solution administration cartridge in which the above-mentioned drug solution enclosure is connected to the above-mentioned drug solution administration flow path switching valve.

[0015]

Embodiments of the present invention will be described below with reference to the drawings.

FIG. 1 is a schematic explanatory view of an administration route using a cartridge for administration of a drug solution of the present invention, and FIG. 2 is an enlarged explanatory view of a main part thereof. The switching valve is provided with a start stopcock section 13 and an end stopcock section 14 at both ends thereof. This start cock part 13
Is provided with one entry port 13a and two subsequent exit ports that can be selected for switching, that is, a first exit port 13b and a second exit port 13c, and the other end stopcock section 14 has a switching port. Two selectable entry ports, a first entry port 14b and a second entry port 14c, and a subsequent exit port 14a are formed.

Here, the start stopcock section 13 and the end stopcock section 14
Is not limited to a specific structure as long as the above-described inlet / outlet port can be formed. In particular, one rotary stopcock provided with a switching flow path is connected to both rotary stoppers with one rotary lever. The coaxial valve system, which is inserted into the hollow part of a fixed stopcock provided with a switching channel so that the parts can be simultaneously switched, has excellent operability and is simple.

FIG. 4 shows an example of this coaxial valve, in which an L-shaped switching flow passage hole 11a communicating with an inlet port 13a provided at one end and opening on the peripheral wall, and being provided at the other end. L communicating with the exit port 14a and opening to the peripheral wall
A first outgoing port 13b and a second outgoing port 13c, which selectively connect the rotary stopcock 11 having a U-shaped switching flow path hole 11b at both ends thereof to the switching flow path hole 11a; A first entry port 14b and a second entry port 14c selectively communicating with the switching channel hole 11b.
Are inserted into the hollow part 12p of the fixed stopcock 12 having the shape of the stopcock, and the start stopcock part 13 and the end stopcock are rotated by one rotation lever 15 which is protruded outward from one end of the rotation stopcock 11. The switching of the flow path of the section 14 can be performed simultaneously.

Here, the rotary stopcock 11 may be in the form of a perfect cylinder having the same diameter as the whole, but it is more reliable to fit the rotary stopcock 11 in the form of a tapered column having a gradually decreasing diameter from the entrance port 13a to the exit port 14a. It is preferred in that case. In this case, it is assumed that the shape of the hollow portion 12p of the fixed stopcock 12 also corresponds to the tapered columnar outer shape of the rotary stopcock 11. Also, 11c
Is an O-ring, and a peripheral groove 11d provided on the outer peripheral wall of the rotating stopcock 11 when the stationary stopcock 12 is inserted into the hollow portion 12p.
It is used by being attached to. Reference numeral 11e denotes a notch for a stopper formed in the rotary stopcock 11 for adjusting the rotation angle of the rotary stopcock 11 by the rotary lever 15 at the time of switching the flow path to each port of the fixed stopcock 12. .

The flow path switching valve 10 shown in FIG. 4 in which the rotary stopcock 11 and the fixed stopcock 12 are combined.
Is configured such that a syringe barrel can be directly connected to the entrance port 13a of the rotary stopcock 11 and is separate from a liquid medicine enclosing body 20 to be described later.
A communication needle 12a is buried in the opening and the opening of the second entry port 14c, respectively, so that the communication needle 12a can be connected to the liquid medicine enclosure 20.

The basic structure of the example of the coaxial valve shown in FIG. 6 is the same as that of the example shown in FIG. 4, except that the fixed stopcock 12 is previously formed integrally with the case 23 of the chemical liquid enclosure 20. It is. Thus, according to this example, the communication needle 12e
Is unnecessary, and a connection operation with the liquid medicine enclosing body 20 is not required.

FIGS. 7 and 8 show another example of the coaxial valve. The inlet port 13a, the first outlet port 13b, and the second outlet port 13c of the start stopper 13 and the outlet port of the stopper 14 are shown. 14a, the first entrance port 14b and the second entrance port 14c are all formed in the fixed stopcock 12 and the hollow portion 12p of the fixed stopcock 12 is formed.
A rotary stopcock 11 having L-shaped switching flow grooves 11p and 11q formed on the peripheral wall is inserted thereinto, and a rotary lever 15 is provided.
As shown in FIG. 9A, the input port 13a and the first output port 13b, and the first input port 14b and the output port 14a are simultaneously communicated through the switching flow grooves 11p and 11q. Or the switching channel groove 11p
And 11q, the entry port 13a, the second exit port 13c, and the second entry port 14c as shown in FIG.
And the outgoing port 14a can be simultaneously selected.

FIG. 10 shows another example of the rotary stopcock 11 in the coaxial valve shown in FIG. 9, in which a switching channel hole is provided inside the rotary stopcock 11 instead of the switching channel grooves 11p and 11q. 11r and 11s are formed, and the flow path hole 1
Selective communication between the entrance and exit ports of the fixed stopcock 12 as described above is possible via 1r and 11s.

The entry port 13a and the exit port 14a
As shown in FIG. 11, by appropriately providing guide paths 12r and 12s in the fixed stopcock 12, an opening can be formed at a desired portion.

The first outgoing port 1 of the start cock 13
As shown in FIGS. 1 and 2, a hollow passage portion 16 is provided between the first stop port portion 14 and the first entrance port 14 b of the stopcock portion 14, and is used as, for example, a flow path for saline. ing. The hollow passage portion 16 may be formed by connecting a tubular body such as a synthetic resin tube between the outgoing port 13b and the incoming port 13b. For example, as shown in FIGS. Hollow part 12 of
It is preferable to form a groove or a hole in the top wall of p to form a passage so that it is not exposed to the outside and is easy to handle.

Reference numeral 20 denotes a liquid medicine enclosing body, as shown in FIG.
The start connection port 21 that can be connected to and opened from the second outgoing port 13c, and the terminal connection port 22 that can be connected to the second inflow port 14c of the end cock 14 of the flow path switching valve 10.
Are respectively formed at the ends.

As the liquid medicine enclosing body 20, a transparent tubular body such as a synthetic resin tube filled with a necessary amount of the liquid medicine in advance is preferable because of excellent observability and particularly easy handling. In this case, the inner diameter and length of the tubular body are appropriately selected depending on the volume of the drug solution to be enclosed, but it is usually preferable that the inner diameter is 2.0 to 4.0 mm and the length is 10 to 25 cm. In the case of such a tubular body, it is preferable to appropriately store the liquid medicine enclosing body 20 in the case body 23, particularly a thin plate-shaped case body as shown in FIG. 4 because of excellent physical distribution and simplicity of handling. In addition, when housed in the case body 23, the start end connection port 21 and the end connection port 22 are made to protrude out of the case body 23 as shown in FIG.

As shown in FIG. 13, it is preferable to provide an openable / closable lid 23a on a part of the case 23 in order to observe the inside. When the encapsulated drug solution is a radiopharmaceutical, the case body 23 is formed of a radiation shielding material such as lead or tungsten, and as shown in FIG. It is preferable to provide a transparent portion 23b made of lead glass or the like for preventing exposure and confirming the administration state.

Numeral 30 denotes a cartridge for administration of a drug solution. In the embodiment shown in FIGS. 3 and 4 as described above, the first outlet port 13 of the stopcock 13 at the start end of the switching valve 10 for administration of a drug solution is used.
a hollow passage portion 16 is provided between the first stop port portion 13b and the first entrance port 14b of the terminal stopcock portion 14, and
The start port 21 of the liquid medicine enclosure 20 is connected to the second outlet port 13c, and the terminal connection port 22 of the liquid enclosure 20 is connected to the second inlet port 14c of the stopcock part 14. It is configured. In the example shown in FIGS. 5 and 6, the fixed stopcock 12 of the switching valve 10 for drug administration and the cover 23 of the drug solution enclosing body 20 are integrally formed.

Next, how to use the cartridge for administration of a drug solution according to the above embodiment will be described. First, in a state where the flow path of the cavity passage portion 16 is opened, the exit port 14 a of the terminal stopcock portion 14 of the chemical solution administration switching valve 10 is
The winged needle 40 with the tube 41 is connected, and the entrance port 13a of the start cock 13 of the switching valve 10 is connected.
Is connected to a syringe 50 filled with physiological saline. Next, the physiological saline in the injection cylinder 50 is partially extruded by the plunger rod 50a, and the start stopper part 13 and the cavity passage part 1 are pushed out.
6. Eliminate the air inside the path constituted by the terminal stopcock part 14 and the winged needle 40 with the tube 41. Next, the blood vessel of the patient is secured by the winged needle 40 at the end of the path.
Next, the operation is switched to the flow path via the chemical liquid enclosure 20 by operating the rotation lever 15 of the switching valve 10. Next, the physiological saline in the syringe 50 is again poured into the plunger rod 50.
a, the chemical solution filled in the liquid medicine enclosure 20 is rapidly or slowly discharged according to the purpose through the start stopper part 13, the liquid stopper 20, the end stopper part 14, and the winged needle 40 with the tube 41. Administer continuously.

[0031]

According to the present invention, two kinds of liquids can be supplied through different branch paths on the way if the flow path switching valve for drug administration is used, so that only one injection cylinder is required. In other words, it becomes possible to administer the drug solution with only one syringe for physiological saline, so that the drug solution can be put on the market in a form other than the prefilled syringe, such as the drug solution enclosure of the present invention.

In addition, since the needle exposed to the outside is unnecessary when using the liquid medicine enclosing body of the present invention, there is no danger of a needle stick accident which is observed when using a prefilled syringe.
In particular, when the medical solution is a radiopharmaceutical, there is no need to store the radiopharmaceutical in an extension tube as in the related art, so there is no risk of radiation exposure and the amount of medical waste is reduced.

Further, by using the cartridge for administration of a drug solution of the present invention, not only the effects of the above-mentioned drug solution inclusion body can be obtained, but also there is no need to prepare various equipment such as a three-way cock and an extension tube at a medical site. Therefore, the connection operation is not required, so that the handling is extremely easy and the risk of virus and germ contamination when connecting the respective devices is naturally reduced. Furthermore, since it is not necessary to switch the flow path for retaining the chemical solution as in the related art, the bolus administration can be performed particularly effectively. Moreover, even when the radiopharmaceutical solution is administered, it is not necessary to secure the blood vessel with the heavy syringe itself, so that there is no risk of administration error, and administration to the target site can be performed extremely easily and reliably.

[Brief description of the drawings]

FIG. 1 is a schematic explanatory view of an administration route using a drug solution administration cartridge according to the present invention.

FIG. 2 is an enlarged explanatory view of a main part of FIG. 1;

FIG. 3 is a perspective view of a cartridge body (separable type) for administering a drug solution of the present invention.

FIG. 4 is an exploded perspective view of the cartridge for drug administration shown in FIG. 3;

FIG. 5 is a perspective view of a cartridge body (integral type) for administering a drug solution of the present invention.

FIG. 6 is an exploded perspective view of the drug solution administration cartridge body shown in FIG.

FIG. 7 is a perspective view of the flow path switching valve of the present invention.

FIG. 8 is an exploded perspective view of the flow path switching valve shown in FIG. 7;

FIG. 9 is an exploded perspective view showing a flow path switching state of the flow path switching valve shown in FIG. 7;

FIG. 10 is a perspective explanatory view showing an example of a rotating stopcock.

FIG. 11 is a schematic explanatory view showing an example of a flow path of the cartridge for administration of a drug solution of the present invention.

FIG. 12 is a perspective view showing an example of an administration device to which the cartridge for administration of a drug solution of the present invention is connected.

FIG. 13 is a perspective view showing an example of an administration device to which a cartridge for administration of a drug solution of the present invention (with an observation lid) is connected.

FIG. 14 is a perspective view showing an example of an administration device to which a cartridge for administration of a drug solution of the present invention (with a transparent portion) is connected.

FIG. 15 is a perspective view showing an example of a conventional connected administration device.

[Explanation of symbols]

 10: Flow path switching valve 11: Rotating stopcock 11a: Switching flow path hole 11b: Switching flow path hole 11c: O-ring 11d: Peripheral groove 11e: Cut 11p: Switching flow path groove 11q: Switching flow path groove 11r: Switching flow Road hole 11s: Switching flow path hole 12: Fixed stopcock 12a: Communication needle 12p: Hollow portion 12r: Guideway 12s: Guideway 13: Starting end stopcock part 13a: Inlet port 13b: Outgoing port 13c: Outgoing port 14: Terminal Stopcock part 14a: Outgoing port 14b: Incoming port 14c: Incoming port 15: Rotating lever 16: Cavity passage part 20: Chemical liquid enclosure 21: Start end connection port 22: End connection port 23: Case body 23a: Cover part 23b: Transparent portion 30: Cartridge for administration of drug solution 40: Wing needle 41: Tube 50: Syringe 50a: Plunger rod

Claims (11)

[Claims] 1. A start cock having one inlet port and two switchable output ports following it, and two switchable input port and one subsequent output port. A flow path switching valve for administering a drug solution, comprising: a terminal stopcock provided with a port. 2. A fixed stopcock having a switching flow passage, wherein a start stopcock portion and an end stopcock portion are capable of simultaneously switching one rotary stopcock having a switching flow passage with one rotation lever. The chemical solution administration flow path switching valve according to claim 1, wherein the flow path switching valve is configured to be inserted into a portion. 3. The medicinal solution administration according to claim 1, wherein a cavity passage is provided between the first outgoing port of the start stopcock and the first ingress port of the end stopcock. Flow switching valve. 4. The flow path switching valve according to claim 3, wherein the hollow passage section is a flow path for physiological saline. 5. The start-end connection port and the second end stop part of the start-stop part of the start-end stop part of the liquid-solution administration flow path switching valve according to any one of claims 1 to 4, which can be connected and opened. A liquid medicine enclosure having a terminal connection port that can be connected to and opened from an entry port. 6. The liquid medicine enclosure according to claim 5, which is used for bolus administration. 7. The liquid medicine enclosure according to claim 5, wherein the liquid medicine enclosure is a tubular body filled with a necessary amount of liquid medicine in advance. 8. The liquid medicine enclosure according to claim 5, wherein the liquid medicine is a radiopharmaceutical. 9. The liquid medicine enclosure according to claim 5, wherein the liquid medicine enclosure is covered with a case body. 10. The liquid medicine enclosing body according to claim 9, wherein the liquid medicine enclosing body and the case body have a transparent portion capable of confirming the flow of the liquid medicine from at least the outside. 11. A liquid medicine enclosing body according to any one of claims 5 to 10, wherein the liquid medicine enclosing body according to any one of claims 5 to 10 is connected to the liquid medicine administration flow path switching valve according to any one of claims 1 to 4. Cartridge for drug solution administration.