JP2001171619A - Ptp packaging body, sealing method and sealing apparatus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a PTP packaging sheet which is free from any damages of basic characteristics for PTP applications and small in curl. SOLUTION: In a PTP packaged body sealing method in which a bottom member formed of a thermoplastic resin sheet is formed in a pocket shape, and a solid is filled therein, and tightly sealed by a lid member formed of an aluminum foil using a seal roll having a seal joint and a seal lower-feed roll, the bite quantity of the seal joint is reduced by adjusting a clearance between the seal roll and the seal lower-feed roll.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a PTP commonly used for packaging solid preparations in the field of pharmaceutical packaging.
(Press-through pack) This invention relates to a method and an apparatus for sealing a package.

[0002]

2. Description of the Related Art In the field of pharmaceutical packaging, PTP packaging, which is generally used for packaging solid tablets such as tablets and capsules, is mainly made of rigid polyvinyl chloride in terms of transparency, moldability, rigidity, and cost. Using a sheet made of (PVC) as a bottom material, forming the bottom material into a pocket shape, filling a solid agent (tablets, capsules, etc.) therein, and sealing with a lid material made of aluminum foil. Yes, it was put into practical use and spread widely in the early 1960s.

[0003] Most of the contents of tablets, capsules and the like are deteriorated or deformed by absorbing moisture.
This has been dealt with by providing secondary packaging such as pillow packaging with a composite film containing aluminum foil, or by using a sheet in which a rigid polyvinyl chloride sheet is composited with a coating of polyvinylidene chloride resin with excellent moisture resistance. These are expensive and have a problem in cost. In addition, the tendency of polyvinyl chloride resin to be avoided due to the problem of disposal is increasing. Therefore, recently, a sheet made of polypropylene resin (PP), which is an olefin-based resin, has been used as a sheet for PTP packaging, paying attention to its moisture-proof property, low cost, and easy processing.

However, polypropylene as a sheet for PTP has a problem that the molding condition range is narrower than that of polyvinyl chloride, and the product is curled and trouble occurs in appearance or in an automatic packaging line accumulation and pillow packaging, and the machine stops. There were problems such as doing. These problems are attributable to the fact that polypropylene is a crystalline resin, and attempts have been made to increase the crystallinity of polypropylene in order to improve curl, using a nucleating agent or slow cooling during sheeting. In addition, methods such as annealing the sheet were performed, but the moldability was conversely deteriorated, and was not suitable for actual use. In order to improve moldability, a method of suppressing crystallinity by adding a petroleum resin to a homopolymer of polypropylene has been adopted, but this method has a disadvantage that impact resistance is significantly impaired. . In order to improve the impact resistance, a method of adding a thermoplastic elastomer (TPE) has been adopted, but the impact resistance is improved with an increase in the amount of TPE added, but at the same time, the rigidity and the moisture resistance are reduced. was there. Attempts have also been made to reduce the crystallinity by quenching at the time of sheeting in order to improve the formability. However, in this method, the stiffness of the sheet becomes extremely weak, and the sheet cannot be used for practical use.
In addition, a method of laminating an amorphous polyolefin with excellent mechanical strength, moldability, transparency, dimensional stability and moisture resistance and a crystalline polyolefin to supplement the impact resistance to form a composite sheet has been attempted. Although good results are obtained in both curl and moldability, the cost of amorphous polyolefins is problematic as a substitute for polyvinyl chloride due to the high price. Thus, at present, it is difficult to derive excellent mechanical properties and properties equivalent to those of polyvinyl chloride only from the viewpoint of the material of the PTP package.

[0005]

SUMMARY OF THE INVENTION In order to solve the above-mentioned problems in the sheet for the bottom material of the PTP packaging, an attempt was made from the point of view of a PTP packaging apparatus. An object of the present invention is to provide a PTP package having a basic function for use.

[0006]

SUMMARY OF THE INVENTION The present invention relates to a seal roll having a bottom material made of a thermoplastic resin sheet formed in a pocket shape, a solid material filled therein, and a sealing material with a lid material made of aluminum foil. A method of sealing a PTP package in which a seal between a seal roll and a roll under the seal is adjusted by adjusting a gap between the seal roll and the roll under the seal. As a preferred embodiment, there is provided the method of sealing a PTP package wherein the gap between the seal roll and the lower seal feed roll is adjusted by a stroke of a seal roll position adjusting cylinder and / or a stroke of an arm above the seal roll. In a further preferred embodiment, the thermoplastic resin sheet is a sheet made of a polypropylene-based resin, and the penetration depth of the seal is 5 to 60 μm.
This is a method for sealing a TP package. The present invention is a PTP package sealed by the above-mentioned sealing method. The present invention also provides a bottom material made of a thermoplastic resin sheet formed into a pocket shape, filled with a solid material therein, and sealed with a seal roll having a seal and a seal lower feed roll with a lid material made of aluminum foil. In a sealing device for a PTP package to be sealed, a seal for the PTP package having a mechanism for adjusting a gap between a seal roll and a lower feed roll by a stroke of a seal roll position adjusting cylinder and / or a stroke of an arm above the seal roll. Device.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The sheet for the bottom material of the PTP packaging used in the present invention may be of any composition as long as it does not impair the basic characteristics for PTP use, and the thickness is not particularly limited. Preferably, the following may be used as constituents of the PTP packaging bottom sheet. As base resin, polyvinyl chloride, polyvinylidene chloride, polypropylene,
Polyethylene, polystyrene, polymethyl methacrylate, polycarbonate, polyester, polyvinyl alcohol, polyvinyl acetate, thermoplastic elastomer, cyclic polyolefin, ethylene-methacrylate copolymer,
Ethylene-vinyl acetate copolymer, ethylene-acrylic acid copolymer, ethylene-vinyl acetate-methyl methacrylate copolymer and other organic carboxylic acid derivatives having an ethylenically unsaturated bond and a copolymer of ethylene and the like. And particularly preferably a polypropylene resin. Examples of the additives include a crystal nucleating agent, an antistatic agent, an ultraviolet absorber, a lubricant, an antioxidant, a light stabilizer, an antiblocking agent, a surfactant, a dye, a pigment, a flame retardant, and a plasticizer. The thickness is preferably in the range of 0.15 to 0.6 mm, and more preferably in the range of 0.20 to 0.35 mm.

The method for producing the PTP packaging bottom material sheet in the present invention is not particularly limited. Coextrusion in which the resin is melt-extruded by several extruders and led to a multilayer die or a feed block to form a sheet. Examples thereof include a dry lamination method in which a single-layer sheet or film forming each layer is laminated using an appropriate adhesive, an extrusion lamination method, a combination of these methods, and a calendar method.

FIG. 1 is a schematic sectional view of a sealing mechanism of a packaging device for a PTP package. A tablet-shaped bottom material sheet (1) and a lid material (2) made of aluminum foil having an adhesive layer on the back surface are sealed by a seal lower feed roll (3) and a seal roll (4). The seal roll (4) is pressed against the seal lower feed roll (3) by the seal roll position adjusting cylinder (5) and the arms (6) and (7), and the gap between them can also be adjusted. However, in the conventional method, in order to increase the sealing area by increasing the sealing area, the sealing roll (4) is fixed in a state where it is strongly pressed against the seal lower feed roll (3). FIG. 2 shows an enlarged schematic view of the surface of the seal roll. Here, on the surface of the seal roll, substantially trapezoidal projections having a taper angle called seal eyes (8) are formed at a fine pitch in the vertical and horizontal directions. FIG. 3 is a schematic cross-sectional view at the time of sealing,
FIG. 4 is a schematic diagram of the upper surface after sealing. The heated sealing eyes (8) are stuck into the aluminum foil (21) of the lid material, the adhesive layer (22) of the lid material, and the bottom material sheet (1) so that they are bonded at the bonding portion (31). . On the other hand, a part of the adhesive layer causes the adhesive to flow to a part other than the seal biting due to heat, thereby generating a pseudo bonded part (32). If the seal penetration amount (9) is large, the bonding area becomes large. When a polypropylene-based resin is used as the bottom material sheet, if the sealing area is large, the package tends to curl.

In the present invention, the gap between the seal roll and the seal lower feed roll is adjusted by the stroke of the cylinder for adjusting the position of the seal roll and the stroke of the arm above the seal roll, thereby suppressing the amount of seal penetration and the sealant adhesion area. I do. As a specific method, a stopper may be inserted into a seal roll position adjusting cylinder, or the length of an arm above the stopper may be adjusted.

In the present invention, the gap between the seal roll and the seal lower feed roll is preferably such that when the sheet and the aluminum foil are sealed at room temperature, a thin seal mark (10) remains on the aluminum foil. As long as the required minimum adhesive strength (500 g / 15 mm or more, there is no practical problem), the strength of extruding the drug, and the moisture-proof property are satisfied, and if the sealing condition is uniform, the smaller the seal penetration depth and the smaller the bonding area, the better. . Preferably,
The sealing depth is 5 to 60 μm, more preferably 5 to 60 μm.
４０40 μm. At this time, the pressure of the seal roll may be increased as necessary in order to make the sealing state uniform. If the sealing depth is less than 5 μm, the adhesive strength may be too weak. If it exceeds 60 μm, the adhesion area becomes large and curling is likely to occur.

[0012]

EXAMPLES The present invention will be described in more detail with reference to the following examples, which are merely illustrative and the present invention is not limited to these examples. << Embodiment 1 >> PP-based single-layer PTP sheet NS-3451
(Sumitomo Bakelite Co., Ltd.), using a PTP molding machine (FCD FBP-M2), using a tablet mold (diameter 10mmφ, depth 5mm), a molding temperature of 140 ℃, After molding at a plug temperature of 130 ° C., an air blow pressure of 0.39 MPa and a line speed of 3.7 m / min, the aluminum foil (thickness: 20 μm) was filled without filling.
(A product obtained by applying a maleic polypropylene as an adhesive layer to a thickness of 5 μm on the hard aluminum foil of Example 1) and sealing. Sealing conditions are as follows: sealing temperature 200 ° C, sealing pressure 0.59MPa
Below, the gap between the seal lower feed roll and the seal roll was adjusted so that the seal penetration amount was about 20 μm. Next, after inserting a slitter at 130 ° C., a molded product punched out into a sheet size (width of 37 mm, length of 94 mm, corner of 5 mmR) was placed on a flat surface, and warpage (curl) of the molded product after 10 minutes of punching was measured. . As a result, the curl was 2.4 mm and the adhesive strength was 720 g / 15 mm, which was good. << Example 2 >> PP-based three-layer PTP sheet CEL-M23
Example 1 using 1B (manufactured by Sumitomo Bakelite Co., Ltd.)
It was molded and sealed in the same manner as described above. Others were evaluated similarly to Example 1, and as a result, curl was 2.3 mm and adhesive strength was 770.
g / 15 mm, which was good.

<Comparative Example 1> In Example 1, the sealing condition was the same as that of the prior art, except that the sealing temperature was 200 ° C., the sealing pressure was 0.59 MPa, and the gap between the seal lower feed roll and the seal roll was not adjusted. At this time, the seal penetration amount is about 65μ
m. As a result of evaluation in the same manner as in Example 1, the curl was 4.0 mm, the adhesive strength was 1150 g / 15 mm, and the curl was large. << Comparative Example 2 >> In Example 2, the sealing condition was changed to a sealing temperature of 20.
At 0 ° C., under a sealing pressure of 0.59 MPa, the gap between the seal lower feed roll and the seal roll was not adjusted, and the adjustment was carried out as before. At this time, the depth of the seal was about 65 μm. Others were evaluated similarly to Example 2, and as a result, curl was 3.6 mm and adhesive strength was 1150 g / 15 mm, and curl was large.

Comparative Example 3 A PTP molding machine (manufactured by CKD Co., Ltd.) was manufactured using a PVC-based single-layer PTP sheet VSS-F120 (manufactured by Sumitomo Bakelite Co., Ltd.).
FBP-M2), using a tablet mold (diameter 10 mmφ, depth 5 mm), molding at 130 ° C., air blow pressure 0.39 Mpa, without using plugs, at a line speed of 3.7 m / min. An aluminum foil (hard aluminum foil having a thickness of 20 μm coated with 5 μm of maleated polypropylene) was sealed without filling the contents.
Sealing conditions are: sealing temperature 200 ° C, sealing pressure 0.59
At a pressure of MPa, the gap between the seal lower feed roll and the seal roll was not adjusted, and the adjustment was performed in the conventional manner. At this time, the depth of the seal was about 65 μm. Others were evaluated in the same manner as in Example 1. As a result, the curl was 2.3 mm and the adhesive strength was 10
90 g / 15 mm, which was good.

* The evaluation method is as follows. (1) curl ;: sheet size (width 37 mm, length 9
A molded product punched at 4 mm and a corner of 5 mmR) was placed on a flat surface, and the warpage of the molded product 10 minutes after punching was measured. For 10 molded articles, four points at each molding pocket angle were measured using calipers, and the average value was obtained and evaluated. (2) Seal penetration: Determined by observation with an optical microscope. (3) Adhesive strength: T-type peeling was performed based on JIS-K-6854, and the peel adhesive strength was measured.

[0016]

According to the present invention, a PTP package having a small curl can be obtained without impairing the basic characteristics for PTP use.

[Brief description of the drawings]

FIG. 1 is a schematic view of a sealing mechanism of a PTP package in a sectional direction.

FIG. 2 is an enlarged schematic view of the surface of a seal roll.

FIG. 3 is a schematic sectional view at the time of sealing;

FIG. 4 is a schematic view in the top direction after sealing.

[Explanation of symbols]

 1. Bottom material sheet 2. Lid material 3. Seal lower feed roll 4. Seal roll 5. 5. Seal roll position adjusting cylinder Arm 7. Arm 8. Seal eyes 9. 9. Seal depth Seal mark 21. Aluminum foil 22. Adhesive layer 31. Adhesive part 32. Pseudo-adhesion part 33. Unbonded part

Claims (6)

[Claims] 1. A bottom material made of a thermoplastic resin sheet is formed into a pocket shape, a solid material is filled in the bottom material, and sealed with a seal roll having a seal and a seal lower feed roll with a lid material made of aluminum foil. A method of sealing a PTP package, wherein a gap between a seal roll and a lower seal feed roll is adjusted to reduce a penetration depth of a seal. 2. The method for sealing a PTP package according to claim 1, wherein the gap between the seal roll and the lower seal feed roll is adjusted by a stroke of a seal roll position adjusting cylinder and / or a stroke of an arm above the seal roll. 3. The P according to claim 1, wherein the thermoplastic resin sheet is a sheet made of a polypropylene resin.
Sealing method for TP package. 4. The penetration depth of the seal is 5 to 60 μm.
The method for sealing a PTP package according to claim 1, wherein: 5. A PTP package sealed by the sealing method according to claim 1. 6. A bottom material made of a thermoplastic resin sheet is formed into a pocket shape, a solid material is filled in the bottom material, and a seal material having a seal is sealed with a lid material made of aluminum foil and a seal lower feed roll are sealed. In a sealing device for a PTP package to be sealed, a mechanism for adjusting a gap between a seal roll and a seal lower feed roll by a stroke of a seal roll position adjusting cylinder and / or a stroke of an arm above the seal roll is provided. Sealing device for PTP package.