JP2001149444A - Hard holder for leukocyte remover - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a hard holder which is mounted on a leukocyte remover having a housing made of a soft resin and enables appropriate filtration of the leukocyte remover. A hard holder 1 is mounted on a leukocyte remover 40 including a soft resin bag-shaped housing 42, a leukocyte removing filter member 45, a blood inflow port 46 and a blood outflow port 47. The hard holder 1 has a main body 2 for accommodating the leukocyte remover 40, and the main body 2 has opposed flat plate-shaped portions 2a formed substantially in parallel with the leukocyte remover during use.
2b, the flat plate portions 21a, 2
The interval 1b is equal to or greater than the thickness of the leukocyte remover 40.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a holder for accommodating a leukocyte remover, and more particularly to a hard holder for accommodating a leukocyte remover whose housing is made of a soft resin.

[0002]

2. Description of the Related Art Conventionally, as a leukocyte remover, a housing, a filter member provided so as to partition the inside of the housing into an inflow side blood chamber and an outflow side blood chamber,
Some include a blood inflow port communicating with the inflow side blood chamber and a blood outflow port communicating with the outflow side blood chamber. Among these, in a leukocyte remover having a housing made of a soft resin, if the leukocyte remover is squeezed by mistake during or after blood filtration, the housing is soft, and unnecessary materials removed by filtration up to that time are pressed. Sometimes leaked out.

When a substance to be filtered flows into the leukocyte remover, the soft resin housing expands, and a large amount of the substance to be filtered is accumulated in the blood chamber on the inflow side. Therefore, the pressure at which the substance to be filtered is pushed into the filter medium becomes small, and the filtration speed may be reduced. Further, Japanese Unexamined Patent Application Publication No.
Japanese Patent Application Laid-Open No. 1-206875 describes a leukocyte removal set having a housing made of a soft resin and a leukocyte collection set including a hard storage container for storing the leukocyte remover. These are designed to appropriately collect white blood cells by regulating the capacity of a leukocyte remover through which blood has passed, specifically, the capacity of an inflow-side blood chamber.

However, Japanese Patent Application Laid-Open No. H11-206875
The leukocyte collection set described in Japanese Patent Laid-Open Publication No. H11-27146, in which the leukocyte remover is stored in a hard container in a compressed state, so that the soft resin housing and the leukocyte removal filter are in close contact with each other, and even if blood is passed through the leukocyte remover. This impedes the flow of blood in the leukocyte remover and causes a decrease in filtration speed. In particular, when the filter member is a porous body,
If the remover is stored in a compressed state in a hard container, the pores of the porous body may be crushed and blood may not flow into the filter.

[0005]

A conventional hard holder is often manufactured integrally with a leukocyte remover.
When the hard holder is attached to the leukocyte remover, the bulk of the product is higher than in the case of using the leukocyte remover alone, leading to an increase in transportation costs. Furthermore, for each leukocyte remover, a hard holder previously manufactured by injection molding or the like is heat-sealed,
The mounting process is complicated by bonding or screwing, which makes the mounting process complicated and leads to an increase in manufacturing cost. Further, in the conventional hard holder, since it is difficult to remove the hard holder after it is attached to the leukocyte remover, both of them are discarded after filtration and used, which causes a problem such as an increase in the amount of waste. Accordingly, an object of the present invention is to provide a hard holder which is attached to a leukocyte remover having a soft resin housing to enable appropriate filtration of the leukocyte remover, and a leukocyte remover having a soft resin housing before use. An object of the present invention is to provide a rigid holder that can be easily attached to a vessel and can be easily removed from a leukocyte remover after use.

[0006]

An object of the present invention is to provide a bag-like housing made of a soft resin and a leukocyte removing chamber provided to divide the inside of the housing into an inflow-side blood chamber and an outflow-side blood chamber. A rigid holder for a leukocyte remover for accommodating a leukocyte remover comprising a filter member, a blood inflow port communicating with the inflow-side blood chamber, and a blood outflow port communicating with the outflow-side blood chamber. And
The rigid holder includes a main body for accommodating the leukocyte remover, and the main body includes substantially parallel opposed flat plate-shaped portions that come into contact with the leukocyte remover in use, and faces the main body. The interval between the flat portions is equal to or greater than the thickness of the leukocyte remover.

[0007] The hard holder for leukocyte remover has an opening for insertion of leukocyte remover provided at one end and a port or a tube connected to the port of the leukocyte remover provided at the other end. It is preferable to include a penetrable penetrating portion, and a guide notch for guiding the port or a tube connected to the port extending from the penetrating portion to the opening. The leukocyte remover hard holder includes a leukocyte remover insertion opening positioned at a side end of the opposed flat plate portion, and a tube provided at an upper end and connected to the port of the leukocyte remover or the port. And a lower end side penetrating part provided at the lower end, through which the port of the leukocyte remover or a tube connected to the port can penetrate, and from the upper end side penetrating part to the opening part An upper end guide notch for guiding the port extending or the tube connected to the port, and a lower end for guiding the port connected to the port or the tube extending from the lower end penetrating portion to the opening; And a notch for side guidance.

[0008] Further, the leukocyte remover hard holder is provided near the center of the upper plate-shaped portion and the leukocyte remover insertion opening located at the side end of the opposed flat plate-shaped portion. The port or an upper penetrating portion through which a tube connected to the port can penetrate, and a tube connected to the port or the port of the leukocyte remover provided near the center of the lower flat plate portion. A penetrating lower penetrating portion, an upper guiding notch for guiding the port or a tube connected to the port extending from the upper penetrating portion to the opening, and the opening from the lower penetrating portion It is preferable to include a lower guiding notch for guiding the port or the tube connected to the port extending to the port. The main body is substantially parallel to the first flat plate in a closed state in which the first flat plate and the first flat plate are openably and closably accommodated and accommodates the leukocyte remover. A second flat plate portion, and the main body portion further comprises:
In the leukocyte remover housed state, the upper end side penetration portion through which the port of the leukocyte remover or the tube connected to the port can pass and the tube of the leukocyte remover connected to the port or the port penetrates. It is preferred to have a possible lower penetration. Further, the main body portion is a first flat plate portion, and is detachably attached to the first flat plate portion, and is substantially parallel to the first flat plate portion in a mounted state in which the leukocyte remover is stored. The main body portion further includes an upper end side penetrating portion through which the port of the leukocyte remover or a tube connected to the port can penetrate and the leukocyte in the leukocyte remover storage state. It is preferable to provide a lower end side penetrating portion through which the port of the remover or a tube connected to the port can penetrate.

Further, it is preferable that the hard holder has a projection on its inner surface. Further, it is preferable that the hard holder has a rib on an inner surface thereof. Further, it is preferable that the protrusions or the ribs are arranged along a direction in which a liquid flows through the inside of the leukocyte remover.

[0010]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS A hard holder for a blood cell remover according to the present invention will be described with reference to an embodiment shown in the drawings. FIG. 1 is a perspective view showing a hard holder for a leukocyte remover according to an embodiment of the present invention. FIG. 6 is a front view of the leukocyte remover housed in the hard holder for a leukocyte remover according to the present invention as viewed from the outflow side blood chamber side. , FIG. 7 is a rear view of the leukocyte remover of FIG. 6,
8 is an enlarged sectional view taken along line AA of the leukocyte remover of FIG. 6, FIG. 9 is a sectional view taken along line BB of the leukocyte remover of FIG. 6, and FIG.
Is a view showing a state in which the leukocyte remover shown in FIG. 6 is partially peeled, FIG. 11 is a view showing a leukocyte removing filter member used in the leukocyte remover of the present invention, and FIG. FIG. 13 is a cross-sectional view of the example of the leukocyte remover in which the hard holder for leukocyte remover is mounted on the leukocyte remover, FIG. 13 is a front view of the leukocyte remover viewed from the outflow side blood chamber, and FIG. It is a C-line enlarged sectional view. The upper side in FIGS. 1 and 6 to 14 is described as “upper” or “upper end”, and the lower side is described as “lower” or “lower end”.

A hard holder 1 for a leukocyte remover according to the present invention.
Is for mounting on a leukocyte remover 40 made of a soft resin. The leukocyte remover 40 includes a soft resin bag-shaped housing 42, a leukocyte removal filter member 45 provided to divide the inside of the housing 42 into an inflow-side blood chamber 43 and an outflow-side blood chamber 44, and an inflow-side blood. A blood inflow port 46 communicating with the chamber 43 and a blood outflow port 4 provided at the other end of the housing 42 and communicating with the outflow side blood chamber 44.
7 is provided. The hard holder for leukocyte remover 1 has a main body 2 for accommodating the bag-shaped housing 42 of the leukocyte remover 40, and the main body 2 is made of a soft resin of the leukocyte remover when used (during blood inflow). The main body 2 includes opposed flat plate portions 21a and 21b formed substantially in parallel and in contact with both surfaces of the bag-made housing 42, and the interval between the opposed flat plate portions 21a and 21b is equal to or greater than the thickness of the leukocyte remover 40. ing. The hard leukocyte remover holder 1 is provided at one end of the leukocyte remover insertion opening 3 and at the other end, and is connected to the blood inflow port 46 or the blood inflow port 46 of the leukocyte remover 40. It has a penetrating portion 4 through which the tube 416 can penetrate, and a guiding notch 5 for guiding the tube 416 connected to the blood inflow port 46 or the blood outflow port 46 extending from the penetrating portion 4 to the opening 3.

As shown in FIGS. 6 to 9, the leukocyte remover 40 housed in the leukocyte remover hard holder 1 includes a soft resin bag-shaped housing 42 and two thermoplastic soft resin sheets 421 and 422. Consisting of sheet 421
Is the blood chamber 43 on the inflow side, and the sheet 422 is the blood chamber 4 on the outflow side.
The one on the four side is used. The inner surface 42a of the outflow-side sheet 422, in other words, the surface of the leukocyte removal filter member 45 facing the surface of the outflow-side blood chamber 44 has unevenness with a height difference of 0.2 to 2 mm. By making the inner surface 42a of the outflow side sheet 422 uneven, the filter member 45 for leukocyte removal is used.
Is pressed against the inner surface 42a of the soft resin bag-shaped housing 42 (the inner surface 42a of the outflow-side sheet 422), thereby preventing the two from adhering to each other. (The inner surface of 422) 42a to secure a blood flow path and prevent a decrease in filtration speed.

In the leukocyte remover 40, as shown in FIGS. 6, 8 and 10, the outflow side blood chamber side sheet 422 is used.
A plurality of ribs 423 are formed on the inner surface 42a of the housing 42 so as to extend substantially in parallel from one end of the housing 42 to the other end (in other words, the blood flow direction). Such a rib 4
By providing the filter 23, the filter member 45 for removing leukocytes and the inner surface 42a of the outflow-side sheet 422 are prevented from adhering to each other, and an effect of guiding filtered blood to the outflow port is exerted. The interval between the plurality of ribs 423 is preferably about 1 to 5 mm, and the ribs 423 have substantially equal intervals.
The width of the rib 423 is preferably about 0.5 to 1 mm. The height (difference) of the rib 423 is 0.2 to 2 mm.
Is particularly preferable, and 0.5 to 1 mm is particularly preferable. The shape of the rib 423 is preferably such that the width decreases toward the tip, such as a triangular pyramid or a hemisphere.

Further, like the leukocyte remover 50 of the embodiment shown in FIGS. 13 and 14, on the inner surface 42a of the outflow side sheet 422, a plurality of vertical ribs 423 extending from one end of the housing 42 to the other end are provided. And a plurality of horizontal ribs 424 that intersect the vertical ribs 423 at substantially right angles. In this case, the interval between the vertical ribs 423 and the horizontal ribs 424 is preferably about 1 to 5 mm, and it is preferable that the ribs have substantially equal intervals. Also, the vertical rib 423
The width of the horizontal rib 424 is preferably about 0.5 to 1 mm. The height (difference in height) of the vertical rib 423 is 0.2 to 2
mm is preferable, and particularly, 0.5 to 1 mm is preferable. The height (difference in height) of the lateral rib 424 is 0.2 to
1 mm is suitable, and in particular, 0.2 to 0.5 mm is preferable. The height of the horizontal rib 424 is equal to the height of the vertical rib 423.
Preferably, the height of the horizontal rib 424 is lower than that of the vertical rib 423 by about 0.3 to 1 mm. Further, the interval between the horizontal ribs 424 is preferably wider than the interval between the vertical ribs 423. Specifically, the interval between the horizontal ribs 424 is 1 to 2 times larger than the interval between the vertical ribs 423.
It is preferably about mm wide.

In the leukocyte removing device 40, the leukocyte removing filter member 45 is composed of a thermoplastic soft resin sheet-shaped frame 451 and a filtering function member 452 having a peripheral portion fixed directly or indirectly to the frame 451. Become. The filtering function member 452 is formed by a laminate of a plurality of filter media. The leukocyte-removing filter member 45 used here has a filtering function portion formed by the filtering function member 452 and a non-filtering function portion formed on the entire periphery of the filtering function portion. The leukocyte-removing filter member 45 is sandwiched between two thermoplastic soft resin sheets. Further, the peripheral portion of the thermoplastic soft resin sheet frame 451 is formed of two thermoplastic soft resin sheets. It is heat-sealed to the resin sheet. As a result, the leukocyte removal filter member 45 divides the space (in the housing 42) in the two thermoplastic soft resin sheets 421 and 422 into the inflow-side blood chamber 43 and the outflow-side blood chamber 44. The two soft resin tubes forming the blood inflow port 46 communicate with the inflow-side blood chamber 43, in other words, the two ends of the soft resin tube open in the inflow-side blood chamber 43. It is heat-sealed at the center of one end (upper end) between the thermoplastic soft resin sheets.
Similarly, two pieces of the soft resin tube constituting the blood outflow port 47 are connected to the outflow side blood chamber 44, in other words, one end of the soft resin tube is opened in the outflow side blood chamber 44. Are heat-sealed to the center of the other end (lower end) between the thermoplastic soft resin sheets.

In particular, in the leukocyte remover 40, as shown in FIG. 11, the filter member 45 for leukocyte removal is composed of a thermoplastic soft resin sheet-like frame 451 having a central portion at one end (upper end) and the other end. A short band-shaped extending portion 451a, 451b protruding outward is provided at the center of the (lower end), and the soft resin tube constituting the blood inflow port 46 is provided between the extending portion 451a and the inflow side resin sheet 421. The soft resin tube that is fused to the sheets 421 and 422 so as to be positioned at
The blood inflow port 46 communicates only with the inflow side blood chamber 43, and the blood outflow port 47 communicates with the outflow side blood chamber 43 by being fused to the sheets 421 and 422 so as to be located between the outflow side resin chamber 51 b and the outflow side resin sheet 422. It communicates only with 44.
The blood inflow port 46 and the blood outflow port 47
In each of the leukocyte removers, the substance to be filtered (not shown)
And a tube 417 for discharging a filtrate (not shown). Thus, the tube 416 communicates with the inflow side blood chamber 43 via the blood inflow port 46, and the tube 417 communicates with the outflow side blood chamber 44 via the blood outflow port 47. The tubes 416 and 417 are connected to the blood inflow port 46 and the blood outflow port 47 by inserting the tubes 416 and 417 inside the soft tubes constituting the ports 416 and 417 and fusing them. For this reason, it is preferable that the outer diameter of the tube is made substantially the same as the inner diameter of the port. As a material for forming the tube,
The resin used for the blood inflow port 46 and the blood outflow port 47 is preferable, and among them, the resin that is easily fused to the blood inflow port 46 and the blood outflow port 47 is preferable.

Further, a filter member 45 for removing leukocytes
Is located outside the broken line shown in FIG.
2 (between two thermoplastic soft resin sheets 421 and 422)
Is fused. For this reason, the leukocyte remover 40 is formed on the periphery of the outflow-side blood chamber 44 between the portion not in contact with the filtering function portion 452 (in other words, the portion having no filtering function, the non-filtering function portion) and the inner surface of the housing. A blood channel 426 is provided. Similarly, the leukocyte remover 40
Is provided with a portion not in contact with the filtering function portion 452 at the periphery of the inflow-side blood chamber 43, in other words, a portion having no filtering function, a blood flow path 427 formed between the non-filtering function portion and the inner surface of the housing. . By providing such a blood flow path formed between the non-filtration function part and the inner surface of the housing 42 at the peripheral edge in the housing, blood circulation at the peripheral edge inside the housing 42 is improved and residual blood at the peripheral edge is improved. To prevent Further, since such a blood flow path exists near the blood outflow port 47 in the outflow side blood chamber 44, the filtered blood flowing through the flow path 425 between the ribs 423 is favorably guided to the blood outflow port 47. As a result, the decrease in the filtration rate is less. And it is preferable that the leukocyte remover holds 5 ml or more of air. The thermoplastic soft resin sheets 421 and 422 constituting the housing 42, and the thermoplastic soft resin sheet frame 4 of the leukocyte removal filter member 45.
As a material for forming the blood inlet port 46 and the blood outlet port 47, a flexible thermoplastic resin is used.

The fixing of the thermoplastic soft resin sheets 421 and 422 constituting the housing 42, the thermoplastic soft resin sheet frame 451 of the leukocyte removing filter member 45, the blood inflow port 46 and the blood outflow port 47 is performed as follows.
Fusing without using an adhesive is preferred. The welding may be external heating welding by heat sealing, or internal welding by a high frequency welder or an ultrasonic welder. In addition, the welding method may be such that all of the above members are fused at the same time, or may be performed in separate steps.

The filter member 45 for removing leukocytes
Is a laminate of a plurality of filter media made of a porous body or a nonwoven fabric. Specifically, 6
Filter media 452a, 452b, 452c, 452d, 4
52e and 452f are laminated. In addition, as a lamination number of filter media, 2-10 sheets are suitable. In this embodiment, since the number of stacked filter media is large, some of the filter media (for example, 3 to 5) are fused to the sheet frame 453 for assisting fusion, and the fusion of the filter media is performed. The outer peripheral edge of the sheet-like frame for attachment assistance 453 is fused to the inner peripheral portion of the sheet-like frame 451 made of thermoplastic soft resin. The porous body used for the filtering function part 452 means a liquid-permeable structure having a large number of fine holes communicating from one surface to the other surface, and is an example of the porous body. Examples of the porous material include natural, synthetic, semi-synthetic, and regenerated porous materials made of organic or inorganic fibers, organic and inorganic porous materials such as sponge foam, and pores formed by elution of pore components, sintering, stretching, and perforation. And a porous body filled or bonded with organic or inorganic fine particles or fine particles. As the filtering function part (filter medium) 452 of the leukocyte removal filter member 45, among the above-mentioned porous bodies, a sponge-like porous polyurethane body and a polyvinyl formal porous body are particularly preferable. In addition, as for the pore diameter of the porous body, if the porous body has large pores, a thick one may be used or a thin one may be laminated and used, and a small pore may be used as it is. is there. Any porous body can be used as long as blood cells can pass through by appropriately selecting the pore diameter and thickness of the porous body. In particular, those having an average pore diameter of 5 to 20 μm are effective for leukocyte removal.

As the nonwoven fabric used for the filtering function part (filter medium) 452 of the leukocyte removal filter member 45, a fiber having a fiber diameter of about 0.3 to 20 μm is used. Fibers made of semi-synthetic fibers such as regenerated cellulose, natural fibers such as cotton, inorganic fibers, and the like are used. Among them, synthetic fibers, for example, polyester fibers such as polyethylene terephthalate, and fibers such as nylon, polypropylene, and polyacrylonitrile are preferably used. Examples of the coating material include a polymer material having a hydroxyl group such as hydroxyethyl acrylate and hydroxyethyl methacrylate, and a basic nitrogen-containing material such as a copolymer of diethylaminoethyl (meth) acrylate and hydroxyethyl (meth) acrylate. Polymer material having a functional group, polyether urethane,
Abcosan and the like can be used. Then, the surface of the nonwoven fabric can be coated with a hydrophilic polymer or coated with an antithrombotic material in order to improve the platelet permeability.

As shown in the embodiment of FIG. 1, the hard holder 1 for a leukocyte remover includes a main body 2, an opening 3 for inserting a leukocyte remover, a penetrating portion 4, and a notch 5 for guiding. I have. The main body 2 is a part for storing the bag-shaped housing 42 of the leukocyte remover 40 therein, and has a length,
Both the width and the thickness are formed larger than the bag-like housing 42 portion. For this reason, the rigid holder 1 is
Hard holder 1
At the time of mounting, without pressing the bag-shaped housing 42,
The leukocyte remover 40 can be stored. In addition, since the thickness of the inside of the hard holder 1 is made substantially the same as the thickness of the bag-shaped housing 42, the leukocyte remover 40 hardly moves in the hard holder 1 after being mounted.

The main body 2 is used during use (at the time of blood inflow).
Are provided with opposing flat plate portions 21a, 21b formed substantially in parallel with both surfaces of the soft resin bag-shaped housing 42 of the leukocyte remover 40, and the distance between the opposing flat plate portions 21a, 21b of the main body 2 is white blood cells. The thickness is more than the thickness of the remover 40, specifically, slightly larger. Here, the "thickness of the leukocyte remover 40" refers to the thickness of the leukocyte remover 40 in a natural state (when blood has not flowed in).
Thus, even when the hard holder 1 is mounted on the leukocyte remover 40, the soft resin thermoplastic sheet 421 and the leukocyte removal filter member 45 do not adhere to each other, and the substance to be filtered that has flowed into the leukocyte remover 40. Since the flow of (blood) is not hindered, the filtration in the leukocyte remover 40 can be performed reliably. In addition, by manufacturing as described above, even if the filter member for leukocyte removal is made of the porous body as described above, without crushing the holes of the porous body, the leukocyte remover is placed in the hard holder. Since it can be stored, filtration can be performed reliably.

Further, the flat plate portion 2 facing the main body 2
The interval between 1a and 21b is smaller than the thickness of the leukocyte remover when the substance to be filtered is passed through the leukocyte remover without mounting the hard holder. Accordingly, by mounting the hard holder 1, the space between the leukocyte remover filter member 45 and the thermoplastic soft resin sheet 421, in other words, the capacity of the inflow-side blood chamber 43 is regulated. Inside the vessel 40 (substance to be filtered)
Is maintained, the pressure for pushing the substance to be filtered into the filter medium 452 is increased, and the filtration speed is improved. In other words, by using the hard holder 1, even when blood flows in, the leukocyte remover 40 can be brought into a state close to that when blood is not flowing (natural state, unused state), and in a state close to the design form. Leukocyte removal can be performed. The filtration speed of the leukocyte remover 40 can be adjusted by adjusting the interval between the opposed flat plate portions 21a and 21b of the hard holder 1. The inside of the main body 2 is such that the leukocyte remover cannot be pressed from the outside during use, and the space between the flat plate portions facing the hard holder is equal to or greater than the thickness of the leukocyte remover and the capacity of the inflow-side blood chamber is reduced. Any shape and size may be used as long as the length is appropriately regulated. The internal size of the main body 2 of the rigid holder 1 is such that the distance between the opposed flat plate portions 21a and 21b is increased by 0 to 3 mm with respect to the thickness of the leukocyte remover.
Is 0 to the length of the leukocyte remover.
Preferably, the length in the direction orthogonal to the longitudinal direction in FIG. 1 is 0 to 3 mm greater than the width of the leukocyte remover.

The insertion opening 3 for the leukocyte remover is a part for inserting the leukocyte remover 40 into the main body 2.
Is formed on the lower end side (one end side). Opening 3
Is made larger than the cross-sectional area along the line AA in FIG. 6 (FIG. 8), so that the leukocyte remover 40 can be inserted into the rigid holder 1 from its upper end. The opening 3
The leukocyte remover may be easily inserted by forming the vicinity in a tapered shape whose diameter increases toward the lower end.

The through portion 4 is a portion through which the blood inflow port 46 of the leukocyte remover 40 or the tube 416 connected to the blood inflow port 46 can penetrate. Specifically, when the hard holder 1 is attached to the leukocyte remover 40, the penetration portion 4 is connected to the tube 4 connected to the blood inflow port 46.
16 is a portion through which the blood inflow port 46 passes after mounting. Therefore, the substance to be filtered can be introduced into the leukocyte remover even when the hard holder is mounted. In the embodiment, the penetrating portion 4 is connected to the blood inflow port 46 at the upper end of the main body 2.
Is formed at a position corresponding to the blood inflow port 4
6 and tube 41 connected to blood inlet port 46
If the flow of the liquid inside 6 is not obstructed,
It may be made at any position on the side (upper end in FIG. 1). In the embodiment of the present invention, the penetrating portion 4 is provided with the port 4.
Although it is formed in the same circle as the outer diameter of No. 6, it is not limited to this, and may be formed in an oval shape or the like. The inner diameter of the penetrating portion 4 is −1 mm or more with respect to the outer diameter of the port 46, and +1.
It is preferable to make it within 0 mm. This is because even if the outer diameter of the port 46 is smaller than the outer diameter of the port 46 by about 1 mm, the port 46 can pass through the penetrating portion 4 due to flexibility and elasticity.
This is because 6 does not come off from the through portion 4. In addition,
In the embodiment, when the hard holder is attached to the leukocyte remover 40, the port 46 penetrates the penetrating portion 4,
The present invention is not limited to this, and the tube 416 may be manufactured so as to penetrate. In this case, it is preferable that the inner diameter of the penetrating portion is formed to have a size of -1 mm or more and +10 mm or less with respect to the outer diameter of the tube. In the embodiment of the present invention, the penetrating portion 4 is formed at the upper end of the main body 2 and the opening 3 is formed at the lower end. However, the present invention is not limited to this. A through portion may be formed.

The guide notch 5 extends from the penetrating part 4 to the opening 3 and serves as a part for guiding the tube 416 to the penetrating part 4 when the hard holder is attached to the leukocyte remover 40. I have. In addition, the notch 5 is provided on the outflow side blood chamber 44 side of the leukocyte remover 40 of the main body 2.
It is formed in a straight line from the penetrating part 4 to the opening 3. The notch 5 is formed on the outflow-side blood chamber side 44 as described above. When the notch is formed on the inflow-side blood chamber side 43, when the inflow-side blood chamber 43 (housing 421) expands, the main body is cut off. This is because the inner wall of the portion expands or the housing 421 protrudes from the notch, so that the capacity cannot be reliably regulated. The notch is
As described above, it is not limited to those manufactured in a straight line,
In order to prevent the tube 416 from coming off the cutout portion, the tube 416 may be formed so as to be bent from the penetration portion 4 in the middle of the insertion opening 3. It is preferable that the width of the cutout portion 5 is made to be −1 mm or more and +10 mm or less with respect to the outer diameter of the port 46 or the tube 416 for the same reason as the through portion 4. It is more preferable that the inner diameter of the penetrating portion is made wider than the outer diameter of the port, and the width of the cutout portion is made smaller than the outer diameter of the tube. By making the tube in this manner, the tube is not easily detached from the hard holder, and the flow of the liquid passing through the port and the tube connected to the port is not obstructed.

The thickness of the hard holder 1 is preferably 2 mm or more in most parts. This is because even if it is a container made of hard resin, if the wall thickness is thin, the hard holder is pushed out by expansion of the leukocyte remover,
This is because the capacity cannot be appropriately regulated. In addition, it is almost always that part of the hard holder 1 is 2 m
This is because the above-described object can be achieved even if the number is less than m. For example, even if the thickness of the upper end portion of the hard holder 1 shown in FIG. 1 is less than 2 mm, the capacity of the leukocyte remover can be appropriately regulated. As the material for forming the hard holder, polypropylene, hard vinyl chloride, polystyrene,
Polyethylene or the like is used, and polypropylene is more preferable. The thickness of the hard holder is 2m
Within the range of m or more, 2-3 mm is more preferable.

Further, a plurality of hard holders 1 are provided on the inner surface thereof.
It is preferable to include a projection (not shown).
Further, the rigid holder 1 has a plurality of ribs (
Is preferably provided. These are white blood cells
Prevents adhesion between the remover and the rigid holder, and removes leukocytes
The hard holder can be easily removed after use
It is provided as follows. In addition, the above-mentioned protruding object and
The ribs are oriented in the direction of flow of the liquid through the leukocytometer.
Preferably, they are arranged along. This allows white
Do not block the flow of liquid through the blood cell remover.
No. The shape of the projection is conical, polygonal pyramid, hemispherical, etc.
Are preferred, and a hemisphere is particularly preferred. Projection height
(Difference in height) is preferably 0.2 to 2 mm.
0.5-1 mm is preferred. Also, the size of the bottom of the protrusion
The height is 0.5 to 10 mm ²The degree is preferred. Also, sudden
The number of protrusions varies depending on the bottom area of the projection, but is 1 cm.
²About 3 to 50 pieces per projection, distance between projections 1 to 10 mm
It is suitable. The rib shape can be triangular pyramid, hemisphere, etc.
It is preferable that the width decreases toward the tip. Re
The spacing between the ribs is preferably about 2 to 6 mm, and the ribs are almost
They are equally spaced. The width of the rib is about 1-3 mm
Degree is suitable, and the height of the rib is preferably about 1 to 3 mm.
It is.

The hard holder 1 is preferably made of a highly transparent resin. This allows
It is possible to confirm in what state the substance to be filtered is circulating, and it is possible to quickly cope with a situation where the substance to be filtered is clogged. As the resin having high transparency, a styrene-based resin such as polystyrene and styrene-butylene copolymer, and a polyolefin-based resin such as polycarbonate, polypropylene, and polyethylene are used. It is not necessary to be completely transparent as long as the state inside the leukocyte remover can be confirmed, and it may be made of translucent resin.

Next, a method of manufacturing the hard holder 1 according to the embodiment of the present invention will be described. First, the front side member 2a including the flat plate portion 21a of the hard holder 1 and the flat plate portion 21b
And the back-side member 2b containing the same is separately injection-molded. Next, the side where the leukocyte remover 40 of the front side member 2a is housed and the side where the leukocyte remover 40 of the back side member 2b is housed face inward so as to be opposed to each other, and their peripheral edges are joined. It is produced by Joining is performed by internal welding using a high-frequency welder or an ultrasonic welder. In addition, a screw hole may be provided in one or both of the front side member and the back side member and joined by screwing.

Next, a method of using the hard holder 1 according to the embodiment of the present invention will be described. First, with the leukocyte remover 40 with the blood inflow port 46 facing upward, the hard holder 1
To be placed below. After that, the tube 416 connected to the blood inflow port 46 is fitted into the cutout portion 5 and the tube 416 is guided to the through portion 4. In this state, the leukocyte remover 40 is located immediately below the insertion opening 3,
The tube 416 on the blood inflow port 46 side passes through the through portion 4 and is located inside the main body 2. Next, with the leukocyte remover 40 fixed, the hard holder 1 is moved downward, the leukocyte remover 40 is inserted from the insertion opening 3, and the hard holder 1 is mounted on the leukocyte remover 40. On the other hand, when removing the hard holder 1 from the leukocyte remover 40, the procedure of the mounting method may be reversed. As described above, the hard holder 1 can be easily attached to the leukocyte remover 40 before filtration, and can be easily removed from the leukocyte remover 40 after filtration.

Next, a hard holder for a leukocyte remover according to another embodiment of the present invention will be described. FIG. 2 is a perspective view showing a hard holder for a leukocyte remover according to another embodiment of the present invention. Hard holder 1 for leukocyte remover of this embodiment
0 includes a main body 12 for accommodating the bag-shaped housing 42 of the leukocyte remover 40, and the main body 12 is substantially parallel to both surfaces of the soft resin bag-shaped housing 42 of the leukocyte remover 40 when in use. The main body 2 has opposed flat plate portions 121a and 121b, and the interval between the opposed flat plate portions 121a and 121b is equal to or greater than the thickness of the leukocyte remover 40. In addition, the hard holder 10 for leukocyte remover includes flat plate-like portions 121a,
Opening 13 for insertion of leukocyte remover located at side end of 21b
The upper end side penetrating portion 14 provided at the upper end and through which the blood inflow port 46 or the tube 416 connected to the blood inflow port 46 of the leukocyte remover 40 can penetrate, and the blood outflow of the leukocyte remover 40 provided at the lower end Induction of the tube 416 connected to the lower end side penetration portion 15 through which the tube 417 connected to the port 47 or the blood outflow port 47 can penetrate, and the blood inflow port 46 or the blood inflow port extending from the upper end side through portion 14 to the opening 13. Notch 16 for guiding the upper side, and opening 13
And a notch 17 for guiding the lower end side for guiding the blood outflow port 47 or the tube 417 connected to the blood outflow port.

The leukocyte remover 40 described above is used for the leukocyte remover of the present invention. The hard holder for leukocyte remover 10 includes a main body 12, an insertion opening 13, an upper end side penetrating part 14, a lower end side penetrating part 15, an upper end side guiding notch 16, and a lower side guiding notch 17. It has.
The main body 12 is a portion for accommodating the bag-shaped housing 42 of the leukocyte remover 40 therein, and is formed to be larger in length, width and thickness than the bag-shaped housing 42. For this reason, the hard holder 10 can store the entire housing 42 portion, and can store the leukocyte remover 40 without pressing the bag-shaped housing 42 when the hard holder 10 is mounted. In addition, since the thickness of the inside of the hard holder 10 is made substantially the same as the thickness of the bag-like housing 42, the leukocyte remover 40 hardly moves in the hard holder 10 after being attached. When the hard holder 10 is mounted, the side of the main body 12 facing the insertion opening 13 is connected to the hard holder 10.
Is formed in a semi-cylindrical shape so as to easily carry

Further, similarly to the main body 2 of the hard holder 1 of the above-described embodiment, the main body 12 is formed substantially in parallel with both surfaces of the soft resin bag-shaped housing 42 of the leukocyte remover 40 during use. Flat plate parts 121 facing each other
a, 121b, and the interval between the opposed flat plate-shaped portions 121a, 121b of the main body 2 is equal to or greater than the thickness of the leukocyte remover 40. The distance between the opposed flat plate portions 121a and 121b of the main body 12 is larger than the thickness of the leukocyte remover when the substance to be filtered is passed through the leukocyte remover without mounting the hard holder, similarly to the main body 2. It is thin. The filtration speed of the leukocyte remover 40 can be adjusted by adjusting the distance between the flat plate portions 121a and 121b of the hard holder 10 facing each other. The inside of the main body 12 is such that the leukocyte remover cannot be pressed from the outside during use, and the space between the flat plate portions facing the hard holder is equal to or greater than the thickness of the leukocyte remover and the capacity of the inflow-side blood chamber is reduced. Any shape and size may be used as long as it is appropriately regulated. The internal size of the main body 12 of the hard holder 10 is:
The distance between the opposed flat plate portions 121a and 121b is increased by 0 to 3 mm with respect to the thickness of the leukocyte remover, and the length in the longitudinal direction of FIG.
Preferably, the length in the direction orthogonal to the longitudinal direction in FIG. 2 is 0 to 3 mm larger than the width of the leukocyte remover.

The insertion opening 13 is a portion for inserting the leukocyte remover 40 into the main body 12, and is formed at a side end of the flat plate portions 121a and 121b facing each other. Also,
Since the opening 13 is formed to have a size equal to or larger than the cross-sectional area of the white blood cell remover 40 in FIG. 6 along the line BB (FIG. 9).
The leukocyte remover 40 can be inserted into the hard holder 10 from its side. In addition, similarly to the hard holder 1, it may be manufactured so that the diameter of the vicinity of the opening of the insertion opening 13 is tapered toward the opening end.

The upper end side penetrating portion 14 is provided at the upper end of the main body 12, and is a portion through which the blood inflow port 46 of the leukocyte remover 40 penetrates. The lower end side penetrating portion 15 is provided at the lower end of the main body 12. , Blood outflow port 4 of leukocyte remover 40
7 is a penetrating part. For this reason, the leukocyte remover 40
The leukocyte remover 40 can perform filtration even in a state where the hard holder 10 is attached to the device. Further, in the embodiment, the upper end side penetrating portion 14 is provided at a position corresponding to the blood inflow port 46 of the main body 12, and the blood outflow port 47 of the main body 12.
The lower end side penetration part 15 is formed at a position corresponding to the flow of the liquid passing through the blood inflow port 46 and the blood outflow port 47 and the tubes 416 and 417 connected to the blood inflow port 46 and the blood outflow port 47. If not hindered, they may be formed at any positions on the upper end side of the main body 12 (on the blood inflow port 46 side) and on the lower end side of the blood main body 12 (on the blood outflow port 47 side). Further, in the embodiment, the upper end side penetrating portion 14 and the lower end side penetrating portion 15 are formed in the same circular shape as the outer diameter of the port 46 and the port 47, but may be formed in an elliptical shape or the like.
In addition, the size of the inner diameter of the penetrating portions 14 and 15 is −1 mm or more with respect to the outer diameter of the port as in the case of the hard holder 1.
It is preferably within 10 mm. In the embodiment, when the hard holder is attached to the leukocyte remover 40, the port 46 penetrates the upper end side penetrating portion 14 and the port 4
7 penetrates the lower end side penetrating portion 17,
The present invention is not limited to this, and the tube 416 may penetrate the upper end side penetrating portion 14 and the tube 417 may penetrate the lower end side penetrating portion 15. In this case, it is preferable that the inner diameter of the penetrating portion is formed to have a size of -1 mm or more and +10 mm or less with respect to the outer diameter of the tube.

In the embodiment, the notch 16 for guiding the upper end is a portion for guiding the blood inflow port 46 or the tube 416 from the opening 13 to the upper end penetrating portion 14.
The lower end guide notch 17 connects the blood outflow port 47 or the tube 417 to the lower end side penetration portion 1 through the opening 13.
It is a part to guide up to 5. In the embodiment,
The notch portions 16 and 17 are respectively provided with the upper end side penetration portion 14,
The tube is formed in a straight line from the lower end side penetrating portion 15 to the insertion opening portion 13. However, the present invention is not limited to this. It is preferable that the widths of the cutout portions 16 and 17 are made to be −1 mm or more and +10 mm or less with respect to the outer diameter of the port or the tube as in the case of the upper end side penetration portion 14 and the lower end side penetration portion 15. .

It is more preferable that the inner diameter of the penetrating portion is made wider than the outer diameter of the port, and the width of the notch is made smaller than the outer diameter of the tube. By making in this way, the port is less likely to be detached from the rigid holder, and the flow of the liquid passing through the port and the tube connected to the port is not obstructed. In addition, the thickness of the hard holder 10 is preferably 2 mm or more in most portions, as in the case of the hard holder 1. As a material for forming the hard holder, the same material as the hard holder 1 is used. The thickness of the hard holder 10 is 2 mm.
Within the above range, 2-3 mm is more preferable. Also,
The hard holder 10 preferably has a plurality of protrusions (not shown) on the inner surface thereof, similarly to the hard holder 1. Further, the hard holder 10 preferably has a plurality of ribs (not shown), like the hard holder 1. In addition, it is preferable that the shape and size of the protrusions or the ribs are the same as those of the hard holder 1. Further, it is preferable that the hard holder 10 is made of a resin having high transparency like the hard holder 1. As the resin having high transparency, the same resin as that of the hard holder is preferable. It is not necessary to be completely transparent as long as the state inside the leukocyte remover can be confirmed, and it may be made of translucent resin.

Next, the hard holder 10 according to the embodiment of the present invention will be described.
A method of manufacturing the device will be described. First, the flat portion 121
The front-side member 12a including a and the back-side member 12b including the flat plate-shaped portion 121b are separately injection-molded. Next, the front member 1
2a for storing the leukocyte remover 40 and the back side member 12b
The hard holder 10 is manufactured by arranging the leukocyte removers 40 facing each other with the sides facing the inside facing inward, and joining their peripheral edges. Joining is performed in the same manner as the hard holder 1.

Next, a method of using the hard holder 10 according to another embodiment of the present invention will be described. First, the side of the leukocyte remover 40 is inserted through the insertion opening 13 formed on the side of the hard holder 10, and the entire leukocyte remover 40 is stored in the hard holder 10. In this case, the blood inflow port 46 passes through the notch 16 from the insertion opening 13 and is guided to the upper end side penetrating portion 14, and similarly, the blood outflow port 47 connects from the insertion opening 13 to the notch 17. And is guided to the lower end side penetrating portion 15. Hard holder 1
When removing 0 from the leukocyte remover 40, the procedure of the mounting method may be reversed. From the above, the rigid holder 10
Can be easily attached to the leukocyte remover 40 before filtration, and can be easily removed from the leukocyte remover 40 after filtration.

Next, a hard holder for leukocyte remover according to another embodiment of the present invention will be described. FIG. 3 is a perspective view showing a hard holder for leukocyte remover according to another embodiment of the present invention, FIG. 15 is a perspective view of a leukocyte remover housed in the hard holder for leukocyte remover shown in FIG. 3, and FIG. Is
FIG. 16 is a central sectional view of the leukocyte remover shown in FIG. 15. The hard holder 20 for leukocyte remover of this embodiment includes a soft resin bag-shaped housing 72 and a filter member for leukocyte removal provided so as to divide the inside of the housing 72 into an inflow-side blood chamber 73 and an outflow-side blood chamber 74. 75, a blood inflow port 76 communicating with the inflow side blood chamber 73, and a housing 72.
Is provided on the other end side of the device, and has a blood outflow port 77 that communicates with the outflow side blood chamber 74. And the hard holder 20
A main body portion 22 for accommodating the bag-shaped housing 72 portion of the leukocyte remover 70; the main body portion 22 includes substantially parallel opposed flat plate portions 221a and 221b that come into contact with the leukocyte remover during use; The interval between the opposed flat plate portions 221a and 221b of the main body 22 is equal to or greater than the thickness of the leukocyte remover 70. Further, the hard holder 20 is provided near the center of the upper plate-shaped portion 221a and the opening 23 for insertion of the leukocyte remover located at the side end of the opposed plate-shaped portions 221a and 221b. An upper penetration portion 24 through which a tube 716 connected to the inflow port 76 or the blood inflow port 76 can penetrate, and a blood outflow port 77 of the leukocyte remover 70 or a blood outflow port 77 provided near the center of the lower flat plate portion 221b. A lower penetration portion 25 through which a tube 717 connected to the outflow port 77 can penetrate, and a blood inflow port 76 extending from the upper penetration portion 24 to the opening 23 or an upper side for guiding the tube 716 connected to the blood inflow port 76. The notch 26 for guidance and the opening 2 from the lower penetration 25
And a lower guiding notch 27 for guiding the blood outflow port 77 extending to 3 or the tube 717 connected to the blood outflow port 77.

The basic structure of the leukocyte remover 70 is that the blood inflow port 76 is provided near the center of the housing 72 on the blood inflow side, and the blood outflow port 77 is provided near the center of the housing 72 on the blood outflow side. Also, except that the outer diameter is made in a disk shape, the leukocyte remover 40
Since the basic structure is almost the same as that described above, the following description will focus on the differences. The leukocyte remover 70 is configured such that one end opening of a soft resin tube constituting the blood inflow port 76 has an inflow side blood chamber 7.
In the vicinity of the center of the thermoplastic soft resin sheet 721 constituting the inflow-side blood chamber 73, a hole having a size substantially equal to the outer diameter of one end of the tube is formed so as to open in the inside 3, and one end of the soft resin tube is formed therein. Is inserted so that the soft resin tube is substantially perpendicular to the surface of the leukocyte removing filter member 75, and the tube and the thermoplastic soft resin sheet 721 are heat-sealed. Similarly, the outflow side blood chamber 74 is configured such that one end opening of the soft resin tube constituting the blood outflow port 77 is opened in the outflow side blood chamber 74.
A hole having a size substantially equal to the outer diameter of one end of the tube is formed in the vicinity of the center of the thermoplastic soft resin sheet 722 constituting the above, so that one end of the tube is substantially perpendicular to the surface of the leukocyte removal filter member 75. It is manufactured by inserting and thermally fusing the tube and the thermoplastic resin sheet 722. Note that the heat fusion is performed by the above-described method.

As shown in FIG. 3, the rigid holder 20 according to the embodiment of the present invention includes a main body 22, an opening 23 for inserting a leukocyte remover, an upper penetration portion 24, a lower penetration portion 25, and an upper guide. Notch 26 and a lower guiding notch 27. The main body part 22 is a part for storing the bag-shaped housing 72 part of the leukocyte remover 70 therein.
Each of the length, width and thickness is larger than the bag-shaped housing 72. For this reason, the hard holder 20 can store the entire housing 72 and can store the leukocyte remover 70 without pressing the bag-shaped housing 72 when the hard holder 20 is attached. Also,
The thickness of the interior of the rigid holder 20 is
The leukocyte remover 70 hardly moves within the hard holder 20 after being mounted, since it is formed in the same shape as the thickness of the hard holder 20.

The main body 22 is similar to the main body 2,
In use, there are opposed flat plate-shaped portions 221a and 221b formed substantially in parallel with both surfaces of the soft resin bag-shaped housing 72 of the leukocyte remover 70. The thickness is not less than the thickness of the leukocyte remover 70. Also, the main body 2
The distance between the opposed flat plate portions 221a and 221b is smaller than the thickness of the leukocyte remover when the substance to be filtered is passed through the leukocyte remover without mounting the hard holder, similarly to the main body 2. ing. In addition, the hard holder 2
The filtration speed of the leukocyte remover 70 can be adjusted by adjusting the interval between the flat portions 221a and 221b that face each other. In addition, the inside of the main body portion 22 cannot press the leukocyte remover from outside during use,
And the interval between the flat plate parts facing the hard holder is
Any shape and size may be used as long as the capacity of the blood chamber on the inflow side is appropriately regulated by the thickness of the leukocyte remover or more. The size of the inside of the main body 22 of the hard holder 20 is such that the opposed flat plate portions 221a,
The interval of 1b is 0 to 3 mm with respect to the thickness of the leukocyte remover.
The length in the longitudinal direction of FIG. 3 increases by 0 to 3 mm with respect to the diameter of the leukocyte remover, and the length in the direction perpendicular to the longitudinal direction of FIG. It is preferred that it be increased.

The opening 23 for inserting a leukocyte remover is a part for inserting the leukocyte remover 70 into the main body 22, and is formed at a side end of the flat plate portions 221a and 221b facing each other. The opening 23 is provided with the leukocyte remover 70 of FIG.
Is manufactured to have a size larger than the cross-sectional area of the central cross-sectional view (FIG. 16). Therefore, the leukocyte remover 70 can be inserted into the hard holder 20 from its side. In addition, similarly to the hard holder 1, it may be manufactured such that the vicinity of the opening of the insertion opening 23 is tapered toward the opening end.

In the embodiment, the upper penetrating portion 24 is
2 is provided at a position corresponding to the blood inflow port 76 at the center of the upper flat plate portion 221a. In a state where the leukocyte remover 70 is inserted into the hard holder 20, the blood inflow port 76 is a portion that can penetrate. I have. On the other hand, the lower penetrating portion 25 is provided at a position corresponding to the blood outflow port in the center of the lower flat plate portion 221b of the main body 22, and when the leukocyte remover 70 is housed in the hard holder, The port 77 is a penetrable portion. The positions where the upper through-portion 24 and the lower through-portion 25 are formed are not limited to those described above, and the tubes connected to the blood inflow port 76 and the blood outflow port 77 and the blood inflow port 76 and the blood outflow port 77 If the flow of liquid passing through 716 and 717 is not obstructed,
2 upper plate-like portion 221a (blood inflow port 76)
Side) and the lower flat portion 221b of the blood body 22
(Blood outflow port 77 side) at any position. In addition, the upper penetration part 24, the lower penetration part 25
In the embodiment, is formed in the same circle as the outer diameter of the port 76 and the port 77, but may be formed in an elliptical shape or the like. Further, the inner diameter of the upper through-hole 24 and the lower through-hole 25 is preferably −1 mm or more and +10 mm or less with respect to the outer diameter of the port, similarly to the hard holder 10. In the embodiment, when the hard holder is attached to the leukocyte remover 70, the port 76 penetrates the upper penetrating portion 24, and the port 77 penetrates the lower penetrating portion 25. Not limited, tube 716
May penetrate the upper penetrating portion 24, and the tube 717 may penetrate the lower penetrating portion 25. In this case, the inner diameter of the penetrating portion is -1 mm or more with respect to the outer diameter of the tube,
It is preferable that it is manufactured in a size within +10 mm.

The hard holder 20 is provided with the upper through-hole 2.
Upper guide notch 26 for guiding blood inflow port 76 extending from 4 to opening 23, and lower guiding notch for guiding blood outflow port 77 extending from lower penetration 25 to opening 23. 27. Further, in the embodiment, the notches 26 and 27 are respectively
4. The tube is formed in a straight line from the lower through portion 25 to the insertion opening 23. However, the present invention is not limited to this. . In addition, the notches 26, 2
7 has a width of -1 mm with respect to the outer diameter of the port or tube as in the case of the upper through-hole 24 and the lower through-hole 25.
As mentioned above, it is preferable that it is manufactured within +10 mm.

It is preferable that the inner diameter of the penetrating portion is made wider than the outer diameter of the port, and the width of the cutout portion is made smaller than the outer diameter of the tube. By making in this manner, the port is less likely to come off the rigid holder, and does not obstruct the flow of the liquid passing through the port and the tube connected to the port. In addition, it is preferable that the thickness of the hard holder 20 be 2 mm or more, as in the case of the hard holder 1. As a material for forming the hard holder, the same material as the hard holder 1 is used. The thickness of the hard holder 20 is 2 mm.
Within the above range, 2-3 mm is more preferable.

The hard holder 20 has a plurality of projections (not shown) on its inner surface, like the hard holder 1. The hard holder 20 preferably includes a plurality of ribs (not shown), like the hard holder 1. In addition, it is preferable that the shape and size of the protrusions or the ribs are the same as those of the hard holder 1. Further, it is preferable that the hard holder 20 is made of a resin having high transparency like the hard holder 1. As the resin having high transparency, the same resin as that of the hard holder 1 is preferable.
It is not necessary to be completely transparent as long as the state inside the leukocyte remover can be confirmed, and it may be made of translucent resin.

Next, the rigid holder 20 according to the embodiment of the present invention will be described.
Will be described. First, the hard holder 20 separately injection-molds the front member 22a including the upper flat portion 221a and the back member 22b including the lower flat portion 221b. Next, the front-side member 22a is arranged such that the side for storing the leukocyte remover and the back-side member 22b are arranged such that the side for storing the leukocyte remover faces inward so that they face each other, and their peripheral edges are joined together. Is done. Joining is performed by the method described above.

Next, a method of using a hard holder 20 according to another embodiment of the present invention will be described. First, the leukocyte remover 70 is inserted through the insertion opening 23 formed in the side surface of the hard holder 20 from the side surface side, and the whole leukocyte remover 70 is stored. At this time, the blood inflow port 76
It passes through the notch 26 from the insertion opening 23 and is guided to the upper through-hole 24. Similarly, the blood outflow port 77
It passes through the notch 27 from the insertion opening 23 and is guided to the lower penetrating part 25. When removing the hard holder 20 from the leukocyte remover 70, a procedure reverse to the procedure of the mounting method may be performed. As described above, the hard holder 20 can be easily attached to the leukocyte remover 70 before filtration, and can be easily removed from the leukocyte remover 70 after filtration.

Next, a hard holder 30 for a leukocyte remover according to another embodiment of the present invention will be described. FIG. 4 shows a hard holder 3 for a leukocyte remover according to another embodiment of the present invention.
FIG. The hard holder 30 for leukocyte remover of this embodiment is a bag-like housing 42 of the leukocyte remover 40.
A main body portion for accommodating the main body portion;
The main body 22 includes opposed flat plate-shaped portions 321a, 321b formed substantially in parallel with both surfaces of the soft resin bag-shaped housing 42 of the leukocyte remover 40 during use.
The distance between the flat portions 321a and 321b facing each other is
The thickness is not less than the thickness of the leukocyte remover 40. Further, the main body 32 includes a first flat plate portion 32a and a first flat plate portion 32a.
A second flat plate portion 32b substantially parallel to the first flat plate portion 32a in a closed state for accommodating the leukocyte remover 40.
Is the leukocyte remover 40 in the housed state.
Upper end side penetrating portion 35 through which blood inflow port 46 or tube 416 connected to blood inflow port 46 can penetrate.
The blood outlet port 47 of the leukocyte remover 40 or the tube 417 connected to the blood outlet port 47 is provided with a lower end side penetration portion 36 through which it can pass.

A leukocyte remover 40 is used in the leukocyte remover of the present invention. The hard holder 30 of the present invention includes a main body 32, an upper end side penetrating part 35, and a lower end side penetrating part 36. The main body 32 includes a first flat plate portion 32a including a flat plate portion 321a and a flat plate portion 321 as shown in FIG.
and a second flat plate portion 32b including the first flat plate portion 32b and the second flat plate portion 32b. The recesses 33a formed on the upper and lower ends of the side edges of the first flat plate portion 32a and the projections 33b formed on the upper and lower ends of the side edges of the second flat plate portion 32b fit inside the concave portions 33a. By combining
The flat plate portion 32a and the second flat plate portion 32b are pivotally supported, and both can be opened and closed. Note that the structure of the main body 32 is not limited to the above. For example, the body part is integrally manufactured so that the thickness of the side end of the body part is reduced,
The first flat plate portion and the second flat plate portion may be openable and closable.

When the first flat plate portion 32a and the second flat plate portion 32b are closed (closed state), the flat plate portion 321a and the flat plate portion 321b are parallel to each other. A space for accommodating the leukocyte remover 40 is formed. The internal dimensions of the main body in the closed state are:
It is preferable that the size is just enough to accommodate the leukocyte remover 40. Similarly to the main body 2, the main body 32 has opposed flat plate-like portions 321 a formed substantially in parallel with both surfaces of the soft resin bag-shaped housing 42 of the leukocyte remover 40 during use (in a closed state), 321b, and flat plate-like portions 321a, 32
The interval 1b is equal to or greater than the thickness of the leukocyte remover 40. Further, the flat plate portion 321 facing the main body portion 32
The distance between a and 321b is smaller than the thickness of the leukocyte remover when the substance to be filtered is passed through the leukocyte remover without mounting the hard holder, similarly to the main body 2.

The filtration speed of the leukocyte remover 40 can be adjusted by adjusting the interval between the flat plate portions 321a and 321b facing the hard holder 30. In addition, the inside of the main body portion 32 cannot press the leukocyte remover from the outside during use, and the space between the flat plate portions facing the hard holder is equal to or larger than the thickness of the leukocyte remover and the capacity of the inflow-side blood chamber is reduced. Any shape and size may be used as long as they are appropriately regulated. The internal size of the main body 32 of the hard holder 30 is:
The distance between the opposed flat plate portions 321a and 321b is increased by 0 to 3 mm with respect to the thickness of the leukocyte remover, and the length in the longitudinal direction of FIG.
Preferably, the length in the direction orthogonal to the longitudinal direction in FIG. 4 is 0 to 3 mm larger than the width of the leukocyte remover. When the leukocyte remover 40 is housed, the main body 32 has an upper end side penetrating portion 35 through which a blood inflow port 46 of the leukocyte remover 40 can penetrate at the upper end and a leukocyte remover 4 at the lower end.
The lower end side penetrating portion 36 through which the zero blood outflow port 47 can pass.
It has. Thus, even when the hard holder 30 is attached to the leukocyte remover 40, the leukocyte remover 4
At 0, filtration can be performed.

The upper end side penetrating portion 35 is formed on the first flat plate portion 32a.
And the semicircle formed on the second flat plate portion 32b overlap each other to form a single circle. Similarly, the lower end side penetration part 36 is formed. In the embodiment, the upper end penetrating portion 35 and the lower end side penetrating portion 36 are made circular, but may be made elliptical or the like.
In the embodiment, the upper end side penetrating portion 35 is provided at a position corresponding to the blood inflow port 46 of the main body 32, and the lower end side penetrating product 36 is provided at a position corresponding to the lower end blood outflow port 47.
However, the flow of the liquid passing through the blood inflow port 46 or the tube 416 connected to the blood inflow port 46 and the blood outflow port 47 or the tube 417 connected to the blood outflow port 47 is not limited thereto. If not hindered, they may be formed at any position on the upper end side of the main body 32 (on the blood inflow port 46 side) and on the lower end side of the main body 32 (on the blood outflow port 47 side). In addition, the upper end side penetrating portion 35 and the lower end side penetrating portion 3
It is preferable that the size of the inner diameter of 6 is −1 mm or more and +10 mm or less with respect to the outer diameter of the port similarly to the hard holder 20. In the embodiment, the leukocyte remover 40 is used.
When the hard holder is attached to the port, the port 46 penetrates the upper end side penetrating portion 35 and the port 47 is connected to the lower end side penetrating portion 36.
The tube 416 penetrates the upper end side penetrating portion 35, and is not limited thereto.
7 may penetrate the lower end side penetrating portion 36.
In this case, the inner diameter of the penetrating portion is smaller than the outer diameter of the tube.
It is preferable that the size is -1 mm or more and +10 mm or less.

The main body 32 is provided with a first flat plate 32a.
A fixing concave portion 34a provided on the side end opposite to the portion supporting the shaft and a fixing convex portion 34b provided on a side end opposite to the portion supporting the second flat plate portion 32b are fitted. When they are combined, they are fixed in a closed state. With such a configuration,
After use, the second flat plate portion can be easily removed from the first flat plate portion. The method of attaching and detaching the first flat plate portion and the second flat plate of the main body 32 is not limited to the above-described method.

The thickness of the hard holder 30 is preferably 2 mm or more in most portions, as in the case of the hard holder 1. As a material for forming the hard holder, the same material as the hard holder 1 is used. In addition,
The thickness of the hard holder 30 is within a range of 2 mm or more.
2-3 mm is more preferable. Also, the hard holder 30
Has a plurality of protrusions (not shown) on the inner surface thereof as in the case of the hard holder 1. Further, the hard holder 30 preferably includes a plurality of ribs (not shown) as in the case of the hard holder 1. In addition, it is preferable that the shape and size of the protrusions or the ribs are the same as those of the hard holder 1.
Further, it is preferable that the hard holder 30 is made of a resin having high transparency like the hard holder 1.
As the resin having high transparency, those described above are preferable.
It is not necessary to be completely transparent as long as the state inside the leukocyte remover can be confirmed, and it may be made of translucent resin.

Next, a method for manufacturing the hard holder 30 will be described. First, the flat portion 32 of the hard holder 30
The first flat plate portion 32a including the flat plate portion 1a and the second flat plate portion 32b including the flat plate portion 321b are separately injection-molded. Next, the first flat plate portion 32a is arranged such that the side for storing the leukocyte remover 40 and the second flat plate portion 32b which faces the side for storing the leukocyte remover 40 face inward, so that they face each other. The concave portion 33a formed in the flat plate portion 32a and the second flat plate portion 3
The hard holder 30 is manufactured by fitting the protrusions 33b formed on the second holder 2b.

Next, a method of using the hard holder 30 according to another embodiment of the present invention will be described with reference to FIG. First,
The main body 32 is opened, and the leukocyte remover 40 is disposed on one of the first flat plate 32a and the second flat plate 32b. At this time, the blood inflow port 46 is connected to the upper end side penetration portion 3.
5 and the blood outflow port 47 is
It is arranged in a portion constituting the lower end side penetration portion 36. Next, the first flat plate portion 32a and the second flat plate portion 32b are closed, the fixing concave portion 34a and the fixing convex portion 34b are fitted, and the hard holder 30 is mounted on the leukocyte remover 40. When removing the hard holder 30 from the leukocyte remover 40, a procedure reverse to the procedure of the mounting method may be performed. As described above, the hard holder 30 can be easily attached to the leukocyte remover 40 before filtration, and can be easily removed from the leukocyte remover 40 after filtration.

Next, a hard holder for leukocyte remover according to another embodiment of the present invention will be described. FIG. 5 is a perspective view of a hard holder for a leukocyte remover according to another embodiment of the present invention. Hard holder 8 for leukocyte remover of this embodiment
0 includes a main body 82 for accommodating the bag-shaped housing 42 of the leukocyte remover 40. The main body 82 is substantially parallel to both surfaces of the soft resin bag-shaped housing 42 of the leukocyte remover 40 in use. The main body 82 has opposed flat plate portions 821a and 821b, and the interval between the opposed flat plate portions 821a and 821b is equal to or greater than the thickness of the leukocyte remover 40. Also, the main body 82
A first flat plate portion 82a, and a second flat plate portion 82b that is detachable from the first flat plate portion 82a and that is substantially parallel to the first flat plate portion 82a in a mounted state in which the leukocyte remover 40 is housed. Further, the main body 82 includes a blood inflow port 46 of the leukocyte remover 40 or an upper end side penetration portion 85 through which a tube 416 connected to the blood inflow port 46 can pass, and a leukocyte in the housed state of the leukocyte remover 40. Blood outflow port 47 or blood outflow port 4 of remover 40
The lower end side penetration part 86 which the tube 417 connected to 7 can penetrate is provided.

The rigid holder 80 of the present invention comprises a main body 82
, An upper end side penetration part 85 and a lower end side penetration part 86. As shown in FIG.
and a second flat plate portion 82b including a flat plate portion 821b. First flat plate portion 82
a and the second flat plate portion 82b are made of different members, and both are made to have substantially the same shape. Further, the main body 82 has fixing portions 84a and 84b on both side ends thereof so that the first flat plate 82a and the second flat plate 82b can be attached and detached. The fixing portion 84a is formed as a concave portion on both sides of the first flat plate portion 82a, and the fixing portion 84b is formed as a concave portion on the second flat plate portion 82a.
The protrusions are formed at positions corresponding to the fixing portions 84a of FIG. Then, the first flat portion 82
a and the second flat plate portion 82b are fixed to each other. Also,
With such a configuration, after use, the second flat plate portion 82b can be easily removed from the first flat plate portion 82a. Note that the method of fixing the second flat plate portion 82b to the first flat plate portion 82a is not limited to the method described above. For example, the first
The flat plate portion and the second flat plate portion may be fixed using different members.

When the first flat plate portion 82a and the second flat plate portion 82b are closed (closed state), the flat plate portion 821a and the flat plate portion 821b are parallel to each other, and the inside of the main body portion 82 A space for accommodating the leukocyte remover 40 is formed. In the embodiment, the internal size of the main body in the closed state is made just large enough to accommodate the leukocyte remover 40. Further, similarly to the main body 2, the main body 82 is used when the leukocyte remover 4 is in use (in a closed state).
And opposing flat plate-shaped portions 821a and 821 formed substantially in parallel with both surfaces of the soft resin bag-shaped housing 42.
21b, and the flat plate portion 82 facing the main body portion 82
The interval between 1a and 821b is equal to or greater than the thickness of the leukocyte remover 40. The distance between the flat plate portions 821a and 821b of the main body 82 facing each other is larger than the thickness of the leukocyte remover when the substance to be filtered is passed through the leukocyte remover without mounting the hard holder, similarly to the main body 2. It is thin.

The filtration speed of the leukocyte remover 40 may be adjusted by adjusting the distance between the flat plate portions 821a and 821b of the hard holder 80 facing each other. In addition, the inside of the main body 82 is such that the leukocyte remover cannot be pressed from the outside during use, and the space between the flat plate portions facing the hard holder is equal to or greater than the thickness of the leukocyte remover and the capacity of the inflow-side blood chamber is reduced. If moderately regulated,
It can be made in any shape and size. The internal size of the main body 82 of the hard holder 80 is such that the distance between the opposed flat plate portions 821a and 821b is increased by 0 to 3 mm with respect to the thickness of the leukocyte remover, and the length in the longitudinal direction of FIG. 0 to 3 mm more than the length of
It is preferable that the length in the direction orthogonal to the longitudinal direction in FIG. 5 is 0 to 3 mm larger than the width of the leukocyte remover. Further, in the state where the leukocyte remover 40 is stored, the main body 82 has an upper end side penetration portion 85 through which the blood inflow port 46 of the leukocyte remover 40 can penetrate at the upper end, and the blood outflow port 47 of the leukocyte remover 40 penetrates the lower end. A possible lower end side penetration 86 is provided. Thereby, even when the hard holder 80 is attached to the leukocyte remover 40, the filtration can be performed by the leukocyte remover 40.

The upper end side penetrating portion 85 is formed by the first flat plate portion 82a.
And the semicircle formed in the second flat plate portion 82b are overlapped to form a single circle. Similarly, the lower end side penetration part 86 is formed. In the embodiment, the upper end penetrating portion 85 and the lower end penetrating portion 86 are made circular, but may be made elliptical or the like.
When the hard holder 80 is attached to the leukocyte remover 40, the blood inflow port 46 of the leukocyte remover 40 passes through the upper end side penetration part 85, and the blood outflow port 47 of the leukocyte remover 40 becomes the lower end side penetration part 86. Pass through. Therefore, even when the hard holder 80 is attached to the leukocyte remover 40, the leukocyte remover 40 can perform filtration.
In the embodiment, the upper end side penetration portion 85 is provided at a position corresponding to the blood inflow port 46 of the main body 82, and the lower end side penetration portion 86 is provided at a position corresponding to the blood outflow port 47 at the lower end side.
However, the flow of the liquid passing through the blood inflow port 46 or the tube 416 connected to the blood inflow port 46 and the blood outflow port 47 or the tube 417 connected to the blood outflow port 47 is not limited thereto. If not hindered, they may be formed at any position on the upper end side (the blood inflow port 46 side) of the main body 82 and the lower end side (the blood outflow port 47 side) of the main body 82, respectively. In addition, the upper end side penetration part 85 and the lower end side penetration part 8
It is preferable that the size of the inner diameter of 6 is −1 mm or more and +10 mm or less with respect to the outer diameter of the port similarly to the hard holder 20. In the embodiment, the leukocyte remover 40 is used.
In a state where the hard holder 80 is attached to the port, the port 46 penetrates the upper end side penetrating portion 85, and the port 47 penetrates the lower end side penetrating portion 86, but is not limited thereto.
The tube 416 may penetrate the upper end side penetration part 85 and the tube 417 may penetrate the lower end side penetration part 86. In this case, it is preferable that the inner diameter of the penetrating portion is formed to have a size of -1 mm or more and +10 mm or less with respect to the outer diameter of the tube.

It is preferable that the thickness of the hard holder 80 be 2 mm or more in most parts, as in the case of the hard holder 1. As a material for forming the hard holder, the same material as the hard holder 1 is used. In addition,
The thickness of the hard holder 80 is within a range of 2 mm or more.
2-3 mm is more preferable. In addition, the rigid holder 80
Has a plurality of protrusions (not shown) on the inner surface thereof as in the case of the hard holder 1. The hard holder 80 preferably includes a plurality of ribs (not shown), like the hard holder 1. In addition, it is preferable that the shape and size of the protrusions or the ribs are the same as those of the hard holder 1.
Further, it is preferable that the hard holder 80 is made of a resin having high transparency like the hard holder 1.
As the resin having high transparency, the same resin as that of the hard holder 1 is preferable. It is not necessary to be completely transparent as long as the state inside the leukocyte remover can be confirmed, and it may be made of translucent resin.

Next, a method for manufacturing the hard holder 80 will be described. First, a first flat plate portion 82a including a flat plate portion 821a and a second flat plate portion 8 including a flat plate portion 821b
2b are separately injection-molded. Next, the first flat plate portion 82
a side for storing the leukocyte remover 40 and the second flat plate portion 82
b, with the leukocyte remover 40 being housed facing inward with the two facing each other, a concave portion 84a formed in the first flat plate portion 82a and a convex portion 84b formed in the second flat plate portion 82b. And the hard holder 80 is manufactured.

Next, a method of using the hard holder 80 according to another embodiment of the present invention will be described with reference to FIG. First,
The main body 82 is opened, and the leukocyte remover 40 is disposed on the second flat plate portion 82b. At this time, the blood inflow port 46
The blood outflow port 47 is disposed at a portion constituting the upper end side penetration portion 85 of the second flat plate portion 82b, and is connected to the second flat plate portion 82b.
It is arranged in a portion constituting the lower end side penetration portion 86 of b. Next, the first flat plate portion 82a is closed to the second flat plate portion, the fixed portions 84a and 84b are fitted together, and the hard holder 80 is mounted on the leukocyte remover 40. When removing the hard holder 80 from the leukocyte remover 40, a procedure reverse to the procedure of the mounting method may be performed. As described above, the hard holder 80 can be easily attached to the leukocyte remover 40 before filtration, and can be easily attached to the leukocyte remover 40 after filtration.
It can be easily removed from the. As described above, the hard holder for leukocyte remover and the leukocyte remover have been described, but their configurations are not limited to those described above.

[0069]

According to the present invention, there is provided a hard holder for a leukocyte remover, comprising a soft resin bag-like housing and a filter member for leukocyte removal provided so as to partition the inside of the housing into an inflow side blood chamber and an outflow side blood chamber. And a blood inflow port communicating with the inflow side blood chamber, and a blood outflow port communicating with the outflow side blood chamber. The holder includes a main body portion for accommodating the leukocyte remover, the main body portion includes substantially flat opposed flat plate portions that come into contact with the leukocyte remover when in use, and the opposed flat plate shape portions of the main body portion are provided. The interval between the portions is equal to or greater than the thickness of the leukocyte remover. For this reason, the hard holder is attached to a leukocyte remover having a housing made of a soft resin to enable appropriate filtration of the leukocyte remover.

The hard holder for leukocyte remover of the present invention comprises an opening for leukocyte remover insertion provided at one end,
A penetrating portion provided on the other end side, through which the port of the leukocyte remover or a tube connected to the port can pass, and a port extending from the penetrating portion to the opening or a tube connected to the port; If the device has a notch for guiding for guiding, it can be easily mounted on a leukocyte remover having a soft resin housing, and can be easily removed from the leukocyte remover after use.

[Brief description of the drawings]

FIG. 1 is a perspective view showing a hard holder for a leukocyte remover according to an embodiment of the present invention.

FIG. 2 is a perspective view showing a hard holder for a leukocyte remover according to another embodiment of the present invention.

FIG. 3 is a perspective view showing a hard holder for a leukocyte remover according to another embodiment of the present invention.

FIG. 4 is a perspective view showing a hard holder for a leukocyte remover according to another embodiment of the present invention.

FIG. 5 is a perspective view showing a hard holder for a leukocyte remover according to another embodiment of the present invention.

FIG. 6 is a front view of the leukocyte remover used in the hard holder for the leukocyte remover of the present invention as viewed from the outflow side blood chamber side.

FIG. 7 is a rear view of the leukocyte remover of FIG. 6;

FIG. 8 is an enlarged cross-sectional view taken along line AA of the leukocyte remover of FIG. 6;

FIG. 9 is a cross-sectional view of the leukocyte remover of FIG. 6 taken along the line BB.

FIG. 10 is a view showing a state where the leukocyte remover shown in FIG. 6 is partially peeled off.

FIG. 11 is a diagram showing a leukocyte removal filter member used in the leukocyte removal device of the present invention.

FIG. 12 is a sectional view showing a state in which the hard holder for leukocyte remover of the present invention is mounted on the leukocyte remover.

FIG. 13 is a front view of another leukocyte remover used in the hard holder for leukocyte remover of the present invention, as viewed from the outflow side blood chamber side.

FIG. 14 is an enlarged cross-sectional view of the leukocyte remover of FIG. 13 taken along the line CC.

FIG. 15 is a perspective view showing another leukocyte remover used for the hard holder for leukocyte remover of the present invention.

FIG. 16 is a center sectional view of the leukocyte remover shown in FIG. 15;

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Hard holder 10 Hard holder 20 Hard holder 30 Hard holder 40 Leukocyte remover 42 Soft resin housing 43 Inflow side blood chamber 44 Outflow side blood chamber 45 Leukocyte removal filter member 46 Blood inflow port 47 Blood outflow port 50 Leukocyte remover 70 Leukocyte remover 80 Hard holder

Claims (9)

[Claims] 1. A soft resin bag-shaped housing, a filter member for leukocyte removal provided so as to divide the inside of the housing into an inflow-side blood chamber and an outflow-side blood chamber, and communicating with the inflow-side blood chamber. A hard holder for a leukocyte remover for storing a leukocyte remover having a blood inflow port and a blood outflow port communicating with the outflow side blood chamber, wherein the hard holder houses the leukocyte remover. A main body portion, the main body portion including a substantially parallel facing flat plate portion that comes into contact with the leukocyte remover in use, and a distance between the facing flat plate portions of the main body portion is:
A hard holder for a leukocyte remover, wherein the thickness of the leukocyte remover is greater than or equal to the thickness of the leukocyte remover. 2. The leukocyte remover hard holder includes a leukocyte remover insertion opening provided at one end and a port of the leukocyte remover or a tube connected to the port provided at the other end. The rigid holder for a leukocyte remover according to claim 1, further comprising a penetrable penetrating portion, and a guide notch for guiding the port or a tube connected to the port extending from the penetrating portion to the opening. . 3. The leukocyte remover hard holder is provided at an upper end of a leukocyte remover insertion opening located at a side end of the opposed flat plate portion, and is connected to the port or the port of the leukocyte remover. An upper end side penetrating portion through which a tube to be inserted can pass, and a lower end side penetrating portion provided at the lower end and through which the port of the leukocyte remover or a tube connected to the port can penetrate, and from the upper end side penetrating portion An upper end guide notch for guiding the port or a tube connected to the port extending to the opening; and guiding the port or the tube connected to the port extending from the lower end through to the opening. 2. A hard holder for a leukocyte remover according to claim 1, further comprising a cut-out portion for guiding a lower end side. 4. The leukocyte remover hard holder is provided near a central portion of an upper plate-like portion and an opening for inserting a leukocyte remover located at a side end of the opposed flat plate-like portion. The port or an upper penetrating portion through which a tube connected to the port can penetrate, and a tube connected to the port or the port of the leukocyte remover, which is provided near the center of the lower flat plate portion. A lower penetrating portion capable of penetrating, an upper guiding notch for guiding the port or a tube connected to the port extending from the upper penetrating portion to the opening, and the opening from the lower penetrating portion The rigid holder for a leukocyte remover according to claim 1, further comprising a lower guide notch for guiding the port or a tube connected to the port extending to the port. 5. The main body section includes a first flat plate section and the first flat plate section.
A second flat plate portion which is supported by the flat plate portion so as to be openable and closable, and which is substantially parallel to the first flat plate portion in a closed state in which the leukocyte remover is housed. In the storage state of the leukocyte remover, the port of the leukocyte remover or the upper end side penetrating portion through which the tube connected to the port can penetrate and the port of the leukocyte remover or the tube connected to the port are connected. The rigid holder for a leukocyte remover according to claim 1, further comprising a lower end side penetrating portion that can penetrate. 6. The device according to claim 6, wherein the main body includes a first flat plate, and the first flat plate.
A second flat plate portion which is detachable from the flat plate portion and is substantially parallel to the first flat plate portion in a mounted state in which the leukocyte remover is housed. In the remover storage state, the port of the leukocyte remover or the upper end side penetration portion through which the tube connected to the port can penetrate, and the port of the leukocyte remover or the tube connected to the port can penetrate. The rigid holder for a leukocyte remover according to claim 1, further comprising a lower end side penetrating portion. 7. The hard holder for a leukocyte remover according to claim 1, wherein said hard holder is provided with a protrusion on its inner surface. 8. The hard holder for a leukocyte remover according to claim 1, wherein the hard holder has a rib on an inner surface thereof. 9. The hard holder for a leukocyte remover according to claim 7, wherein the protrusions or the ribs are arranged along a direction in which a liquid flows through the leukocyte remover.