JP2001046019A - Nutritional composition derived from citrus - Google Patents

Abstract

(57) Abstract: A composition comprising a soluble fraction obtained by adjusting a polar solvent extract such as citrus fruits and juice residues to pH 5.5 to 8.5 or a processed product thereof. object. [Effect] A highly safe drug and / or food / drink having excellent anti-hypertriglyceridemia action, anti-visceral fat accumulation action and anti-hepatic function lowering action is produced.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition having excellent physiological activity and health and health effects,
More specifically, the present invention relates to a citrus-derived pharmaceutical and / or food / drink type composition.

[0002]

2. Description of the Related Art In recent years, the mechanism of the onset of arteriosclerosis has been elucidated, and hypertension, abnormal glucose tolerance and abnormal lipid metabolism have been regarded as important risk factors. Dyslipidemia and obesity such as hypertension, diabetes and hyperlipidemia and obesity were recognized as independent diseases, but recently these factors are more likely to accumulate in individuals than independent diseases. There are many cases, and it has become clear that they are closely related to the onset of arteriosclerosis such as ischemic heart disease.

1988, Reaven et al. (Diabetes, 37; 1595-
1607, 1988), conducted in a study of 100 non-obese, normal glucose-tolerant men, showed that about 25% of them had a similar decrease in insulin sensitivity as non-insulin-dependent diabetes mellitus (NIDDM), Syndrome X was defined as a state in which insulin resistance, impaired glucose tolerance, hyperinsulinemia, hypertriglyceridemia, low- and high-density lipoprotein (HDL) cholesterol, and hypertension were combined as an accumulation of arteriosclerosis risk factors. . The following year, Kapl in 1989
an et al. (Arch. Intern Med. 149; 1514-1520, 1989) also
In a similar condition mediated by insulin resistance, upper body obesity, impaired glucose tolerance, hypertriglyceridemia, and hypertension are referred to as the deadly quarted,
The risk factors for arteriosclerosis have been accumulated, that is, they are collectively referred to as multiple risk factors.

[0004] In 1991, De Fronz
(Diacetes Care 14; 173-194, 1991) referred to as insulin resistance syndrome. Genetic factors are thought to account for the majority of insulin sensitivity, but Nakamura et al. (Atherosclerosis 10
7; 239, 1994) proposed the concept of visceral fat syndrome, in which visceral fat accumulating in the abdominal cavity also contributes to a condition that accumulates a number of risk factors for arteriosclerosis. The accumulation of visceral fat is modified not only by genetic predisposition but also by environmental factors such as aging, lack of exercise, excessive intake of sucrose and lipids, and stress, such as reduced eating habits and physical activities. That is why it is also called.

[0005] The accumulation of visceral fat existing upstream of the pathological conditions of lifestyle-related diseases, as well as lifestyle-related diseases such as hypertension, hyperlipidemia, and diabetes, is caused by not only arteriosclerosis,
There is growing recognition that it may lead to other serious causes such as heart and kidney diseases, and the number of patients is expected to increase further in view of the future aging society. Under these circumstances, there is a need in the art for the development of compositions, pharmaceuticals, and foods that have the effect of suppressing visceral fat accumulation and reducing or preventing the onset of hypertriglyceridemia.

[0006] On the other hand, with the increase in consumption of citrus juice such as orange juice, a large amount of juice cake containing pericarp and the like is produced as a by-product in the production process. Has been discarded. However, squeezed cake is easily rotted, and effective treatment is strongly demanded from the viewpoint of preventing pollution.

[0007]

SUMMARY OF THE INVENTION The present invention has been made to meet the above-mentioned demands in the art.

[0008]

DISCLOSURE OF THE INVENTION The present invention has been made in order to achieve the above-mentioned object. The present inventors have conducted various studies and have recently found that spontaneously hypertensive rats (SH)
R) has been elucidated (Aitman, TJ et. Al .;
Nature Genet., 21; 76-83, 1999). Furthermore, SHR has been shown to have pathologies similar to human insulin resistance syndrome / visceral fat syndrome, and has been recognized as a model animal for these pathological conditions (Tobe et al., History of Medicine, 189 (9) 571-582, 1999), and the present inventors newly focused on SHR which is a human animal model of insulin resistance syndrome / visceral fat syndrome,
When Satsuma mandarin orange juice residue extract was given, it was discovered that Satsuma mandarin orange juice residue extract had an effect of reducing symptoms or preventing the onset of these pathological conditions.

The present invention has been completed as a result of further research based on this new finding. Hereinafter, the present invention will be described in detail.

To produce the composition according to the invention, the citrus raw material is extracted with a polar solvent. As the citrus raw material, at least one of a citrus fruit, squeezed cake (residue of squeezed juice), pericarp, mesocarp, and carbohydrate membrane is used.
Mixtures of more than one species can also be used. The raw material may be a processed product which has been subjected to processing such as cutting, crushing, crushing, crushing, concentration, and drying, as necessary.

The citrus fruits used in the present invention are not limited, and include commercially available oranges, grapefruits, lemons, summer tangerines, sweet summer tangerines, daidai, navel, bontan, pomelo, bampeille, kumquat, yuzu and kabosu. , Including all citrus fruits such as mandarin oranges.

The citrus raw material is extracted with a polar solvent. The extraction is performed at 0 ° C. to room temperature to the boiling point, usually at normal temperature, and the extraction time is 5 minutes.
Minutes to 24 hours. No harmful effects are observed even if the extraction is performed for a longer time. The extraction may be either standing or stirring.

Examples of polar solvents include alcohols such as water and ethanol; glycerin; glacial acetic acid; ethers such as diethyl ether and tetrahydrofuran; ketones such as acetone and methyl ethyl ketone; nitriles such as acetonitrile; Examples thereof include halogenated hydrocarbons. These solvents may be used singly or as a mixture of two or more. Preferred examples of the polar solvent include highly safe water and ethanol.

The pH of the polar solvent extract is adjusted to 5.5 to 8.5, preferably 6 to 8, using an acid or an alkali. When water is used as the polar solvent, the extract is slightly acidic, and the pH is adjusted using a commonly used alkali such as calcium hydroxide, magnesium hydroxide, sodium hydroxide, or potassium hydroxide. In addition, for example, if extraction processing of a citrus raw material is performed using water to which these alkalis are added, extraction and pH adjustment can be performed simultaneously.

Next, the soluble fraction is fractionated from the pH-adjusted solution of the polar solvent extract. The fractionation may be carried out by a conventional method, and one or more methods of fractionating a soluble fraction, such as centrifugation, filtration (pressurized or reduced pressure), decantation, etc., are appropriately employed.

The soluble fraction thus obtained is used as it is or as a processed product thereof as an active ingredient of the composition according to the present invention. The processed product may be at least one of a concentrate, a pasted product, a dried product, an emulsified product, and a diluted product. If necessary, the product may be further subjected to solvent extraction or chromatography to be purified and fractionated. May be used.

The soluble fraction (treated product) has an anti-hypertriglyceridemia effect, an anti-visceral fat accumulation effect, and an anti-hepatic function lowering effect, as apparent from the examples described later. The composition is a food and drink utilizing these effects, food and drink for specified health use, health drink, health food, nutritional food, functional food, diet food, as well as patients with hypertriglyceridemia or visceral fat accumulation or decreased liver function It can be used as a nutritional composition and other various types of foods and drinks for people who have or may have such fears. In addition, they can be used as pharmaceuticals such as drugs for preventing, ameliorating, and treating these diseases, symptoms, and conditions.

The amount of the active ingredient may be arbitrarily determined, but may be determined as appropriate according to the purpose of use (prevention, health, or treatment), the age of the patient, the administration method, the dosage form, and the like. When using a concentrated concentrate, usually 0.0001 to 10%
Is appropriate. However, when taken for a long period of time for health or health maintenance purposes, the amount may be smaller than the above range, and since the present active ingredient has no safety problem, Even if it is used in large quantities, it may not matter. Actually using mouse 1
As a result of the 0-day acute toxicity test, no death was observed even with oral administration of 1000 mg / kg.

When used as a food or drink type composition, the present active ingredient can be used as it is or in combination with other foods or food ingredients, and can be used according to a conventional method. The composition according to the present invention using the present active ingredient,
It can be solid (powder, granule, etc.), paste, liquid or suspension, but is formulated into a health drink using sweeteners, sours, vitamins and other ingredients commonly used in the production of drinks. It is preferable to make it.

When used as a pharmaceutical type composition, the active ingredient is administered in various forms. Examples of the administration form include tablets, capsules, granules, powders,
In addition to oral administration with syrups and lozenges, etc., administration with infusions, enteric solutions, rectal preparations and the like can be mentioned. These various preparations, excipients in the main drug according to the usual method,
The preparation can be made using known auxiliary agents usually used in the technical field of pharmaceutical preparations, such as a binder, a disintegrant, a lubricant, a flavoring agent, a solubilizing agent, a suspending agent, and a coating agent. The amount used depends on the symptoms, age, weight, administration method and dosage form, etc., but usually, for adults,
In the case of oral administration, 0.1 to 2000 mg per day
It is appropriate to administer in 4 to 4 divided doses. Hereinafter, examples of the present invention will be described.

[0021]

Example 1 1 ton of Satsuma mandarin orange fruit was squeezed, and the pH was adjusted to 6-8 by adding 50 kg of water and 2 kg of calcium hydroxide to the lees (500 kg), and then pressed to squeeze 250 kg of juice. I got The juice is centrifuged (750
0G) to fractionate the soluble fraction, and further heat and concentrate under reduced pressure to obtain a concentrate (50 kg), which was used as an extract of Satsuma mandarin orange juice residue.

[0022]

Example 2 50 kg of water and 2 kg of calcium hydroxide were added to lees (500 kg) after squeezing 1 ton of Unshu mandarin orange fruit to adjust the pH to 6 to 8, and then squeezed by pressing. 250 kg of juice was obtained as an extract of Satsuma orange juice residue. That is, this extract corresponds to a concentration of 1/5 of the extract of Satsuma mandarin orange juice residue produced in Example 1.

[0023]

Example 3 Intake of Concentrated Extract of Citrus Fruit Juice Residue on Blood Lipid Concentration, Visceral Fat Accumulation and Liver Function of Spontaneously Hypertensive Rats (SHR) Fed a Purified Feed with Sucrose Energy Ratio of 50% Influence

(1) Breeding of Experimental Animals 17-week-old male spontaneously hypertensive rats (SHR / Hos, Hoshino test animal breeding house) preliminarily bred on a commercial solid feed (Claire, CRF-1) and adapted to the environment ) Seventeen rats and eleven male normotensive rats of the same age (WKY / Hos, Hoshino test animal breeding house) were divided into two groups so that the average values of body weight and blood pressure were equal.

On the one hand, the basic food itself having a sucrose energy of about 50% as shown in Table 1 (hereinafter referred to as a comparative group), and on the other hand, the residue of Satsuma mandarin juice obtained in Example 1 with respect to 100 g of the basic food A test meal mixed with 40 g of the extract (hereinafter referred to as an experimental group) was provided and bred for 5 weeks.

(Table 1) Table 1: Basic food composition (feed containing 1% salt)組成 Composition (g / kg basic diet) ──────────────────────────────────── α-corn starch 100 sucrose 552 milk casein 200 L-cystine 3 lard 50 soybean oil 20 mixed with vitamins (compounded with AIN-93G, choline bitartrate) 10 mixed with minerals (mixed with AIN-93G) 35 sodium chloride 10 cellulose 20 ───────────────────────────────── ＊ Sweet mandarin orange juice residue extract added food: basic food 100g + unshu mandarin orange juice 40 g of juice residue extract

09: 00-1 after breeding on a test diet for 5 weeks
Blood was collected from the portal vein and abdominal aorta at 1:00 to obtain plasma. Further, as visceral fat, fat tissues at three sites of mesenteric fat, epididymal fat and perirenal fat were excised and weighed.

(2) Test Results The weight gain during the test period was greater in the WKY rats than in the SHR, but in the same strain, the group without the extract of the extract of Satsuma mandarin juice (comparative group) and the group with the extract (experiment) Group) did not differ.

FIG. 1 shows the total visceral fat tissue weight per empty body weight. The visceral fat total tissue weight was represented by the sum of the weights of mesenteric fat, epididymal fat and perirenal fat. As shown in the figure, the visceral fat weight of the SHR was reduced by ingesting the extract of Satsuma mandarin juice residue.

FIG. 2 shows the plasma triglyceride concentration, and FIG. 3 shows the high-density lipoprotein (HDL) cholesterol concentration.
FIG. 4 shows the ratio of plasma cholesterol to HDL. The following became clear from these results.
Spontaneously hypertensive rats (SHR) have higher plasma triglyceride levels and lower HDL-cholesterol levels than normotensive WKY. Thus, SHR plasma lipids showed the kinetics of multiple risk factor syndrome, called insulin resistance syndrome or visceral fat accumulation syndrome.

Ingestion of the extract of Satsuma mandarin orange juice reduced the plasma triglyceride concentration and increased the HDL-cholesterol concentration of SHR, a model animal for insulin resistance syndrome / visceral fat syndrome. Furthermore, the ratio of total cholesterol to HDL was increased in normal WKY by ingestion of the extract of Satsuma mandarin juice residue.

Glutamate / pyruvate transaminase (GPT) activity, which is an index for evaluating liver function, is higher in SHR than in WKY (FIG. 5), suggesting a decrease in liver function in SHR. The GPT activity of this SHR was also recovered by ingesting the extract of the residue extract of Unshu mandarin orange juice.

[0033]

[Example 4] Examination of the onset period of the effect of citrus fruit juice residue extract concentrate intake on hypertriglyceridemia in spontaneously hypertensive rats (SHR)

(1) Rearing of experimental animals Male spontaneously hypertensive rats (SHR / Ho) at the age of 10 weeks
s, Hoshino Test Animal Farm) 15 male normotensive rats of the same age (WKY / Hos, Hoshino Test Animal Farm)
Ten were preliminarily reared on a commercial solid feed (Claire, CRF-1) and acclimated to the environment, and then reared on a semi-purified feed (basic diet) shown in Table 2 for one week. Blood was collected from the tail vein, the plasma triglyceride (TG) concentration was measured, and the blood was divided into two groups so that the average of the plasma TG concentration and the average of the body weight were the same.

On the one hand, the basic food itself shown in Table 2 (hereinafter, comparative group), and on the other, a test food in which 20 g of the extract of Satsuma mandarin juice prepared in Example 1 was mixed with 100 g of the basic food (Hereinafter referred to as an experimental group).

(Table 2) Table 2: Basic diet composition (feed containing 1% NaCl)組成 Composition (g / kg basic diet) ──────────────────────────────────── α-corn starch 572 sucrose 100 milk casein 200 L-cystine 3 soybean oil 50 mixed with vitamins (containing AIN-93G, choline bitartrate) 10 mixed with minerals (containing AIN-93G) 35 sodium chloride 10 cellulose powder 20 塩 化──────────────────────────────── * Sanshu mandarin orange juice extract added food: basic food 100g + unshu mandarin orange juice 20 g of residue extract

Blood was collected from the tail vein before breeding on the experimental diet and on the 10th and 17th days after the breeding on the experimental diet was started. Considered changes.

(2) Test Results FIG. 6 shows the daily changes in the plasma TG concentration of SHR and WKY subjected to the experiment from the age of 11 weeks to the age of 13 weeks.
The plasma TG concentration of normotensive WKY remained unchanged throughout the experiment and was not affected by ingestion of the extract of Satsuma mandarin juice. On the other hand, SHR increases plasma T with age.
Although the G concentration increased, the increase in plasma TG concentration was suppressed by ingestion of the extract of Satsuma orange juice residue. According to these test results, high TG by extract extract of Mandarin orange juice juice residue
The effect of suppressing the concentration is one of the effects of ingesting the extract of the residue extract of Satsuma mandarin juice.
On day 0, it was revealed that the expression was effective.

[0039]

Example 5 Effect of Ingestion of Citrus Fruit Juice Residue Extract Concentrate on Hypertriglyceridemia in Spontaneously Hypertensive Rats (SHR)

(1) Breeding of Experimental Animals Spontaneously hypertensive male rats of 10 weeks of age (SHR / Ho)
s, Hoshino Test Animal Farm) 15 male normotensive rats of the same age (WKY / Hos, Hoshino Test Animal Farm)
After 10 rats were preliminarily reared on a commercially available solid feed (Claire, CRF-1) and acclimated to the environment, they were reared for another week on a semi-purified feed (basic diet) shown in Table 2. Each group was divided into two groups so that the average body weight was the same.

On one side, the basic diet itself shown in Table 2 (hereinafter, comparative group), and on the other side, a test in which 20 g of the extract of Satsuma mandarin juice prepared in Example 2 was mixed with 100 g of the basic diet. One week with food, Unshu mandarin orange juice residue extract 4
The animals were bred for an additional week for a total of two weeks with a test meal (hereinafter, experimental group) mixed with 0 g.

(2) Test Results The intake of the active ingredient in the extract of the residue extract of Satsuma mandarin orange juice is about 1/10 to 1/5 of that in Examples 3 and 4, but the plasma TG concentration is shown in FIG. In addition, as shown in FIG. 8, the glutamate / pyruvate transaminase (GPT) activity shows that even at this intake, the action of reducing the hyperTGemia and the action of restoring the liver function by ingesting the extract of Satsuma mandarin juice residue are effective. Expressed.

[0043]

Example 6 100 g of the extract of the residue of Satsuma mandarin orange juice obtained in Example 1, 150 g of sugar, 15 g of honey, 1 g of ascorbic acid, 0.5 g of citric acid, and 1 kg of water by adding an appropriate amount of flavoring agent
This was sterilized at 95 ° C. for 20 minutes, and 100 ml was aseptically filled into bottles to produce a food and drink type health drink.

[0044]

Example 7 200 g of Satsuma mandarin orange juice residue extract obtained in Example 1, 5 g of tocopherol acetate, 10 g of thiamine nitrate
g, nicotinamide 20 g, anhydrous caffeine 50 g,
Deionized water was added to the appropriate amount of benzoate and perfume to make up to 30 L, sterilized, and then aseptically filled into 30 ml bottles,
Produced health drinks as pharmaceuticals.

[0045]

Example 8 Using the freeze-dried powder (1) of the extract of Satsuma orange juice residue obtained in Example 1, tablets were produced with the following composition. (Blend) (1) 50 g of freeze-dried powder (2) 90 g of lactose (3) 29 g of corn starch (4) 1 g of magnesium stearate

(1), (2) and (3) (17 g)
Was mixed and granulated with the paste prepared from (3) (but 7 g). (3) (However, 5 g)
And (4) are added and mixed well. This mixture is compressed by a compression tablet machine, and 50 mg of the active ingredient (1) is obtained per tablet.
1000 tablets were produced.

[0047]

As described above, according to the present invention, as a result of a test on a spontaneously hypertensive rat, which is a model animal for insulin resistance syndrome / visceral fat syndrome, it was found that the extract of this extract from Satsuma mandarin juice has a high level. The effect of reducing triglyceridemia was already observed on day 10 of ingestion, and the effect was maintained for a long period of one month or more. It also exerted a preventive effect on the progression of age-related hyperlipidemia. In addition, even under dietary conditions such as high sucrose intake where visceral fat is likely to accumulate and the symptoms of hyperlipidemia further progress, the inhibitory effect of the extract of Satsuma mandarin juice residue could be confirmed. In addition, the addition of 1% of the solid content of the extract of Satsuma mandarin juice was effective in reducing hypertriglyceridemia in spontaneously hypertensive rats.

The composition according to the present invention is derived from fruit raw materials such as citrus fruits and squeezed residue thereof, which suppresses visceral fat accumulation, reduces hypertriglyceridemia, and reduces H
It has an effect of restoring DL-cholesterolemia or improving liver function decline. By regularly using this food as a dietary supplement, it is expected that symptoms of lifestyle-related diseases caused by eating habits such as aging, lack of exercise, and excessive intake can be reduced or prevented from developing.

According to the present invention, the effective use of industrial wastes in the squeezing of citrus fruits enables the accumulation of visceral fats due to aging and living environment factors, and the lifestyle induced by hyperlipidemia and the like. It is a nutritional composition that can be expected to prevent the onset of habitual diseases and reduce symptoms, and can be widely applied to healthy people to those who need nutritional treatment with enteral nutrition. Also, since it is a natural product, it is highly safe and can be taken for a long time.

In the present invention, in addition to citrus fruits themselves, in addition to citrus fruits themselves, pericarp, mesocarp, carcinoma, juice residue and the like can be used, and these are generated when juice is squeezed. Secondary products, most of which are usually discarded. Extracting the active ingredient again by using this waste can be said to be a very effective invention in terms of industrially effective use of natural product waste.

[Brief description of the drawings]

FIG. 1 shows the effect of ingestion of extract from Satsuma mandarin juice on the amount of visceral fat accumulation in spontaneously hypertensive rats under a dietary condition with a sucrose energy ratio of 50%.

FIG. 2 shows the effect of ingestion of Satsuma mandarin juice residue on plasma triglyceride concentration of spontaneously hypertensive rats under dietary conditions with a sucrose energy ratio of 50%.

FIG. 3 shows the effect of ingestion of Satsuma mandarin juice extract on high-density lipoprotein (HDL) cholesterol concentration in spontaneously hypertensive rats under dietary conditions with a sucrose energy ratio of 50%.

FIG. 4 shows the effect of ingestion of the extract extract of Satsuma mandarin juice on the distribution ratio of high-density lipoprotein (HDL) in plasma cholesterol of spontaneously hypertensive rats under dietary conditions with a sucrose energy ratio of 50%.

FIG. 5 shows the effect of ingestion of Satsuma mandarin juice extract residue on liver function (glutamic acid / pyruvate transaminase activity (GPT activity)) of spontaneously hypertensive rats under dietary conditions with a sucrose energy ratio of 50%.

FIG. 6 shows the daily effect of intake of extract extract of Satsuma mandarin juice on plasma triglyceride concentration in spontaneously hypertensive rats.

FIG. 7 shows the results of examining the intake amount of extract from Satsuma mandarin juice that is effective in lowering plasma triglyceride concentration in spontaneously hypertensive rats.

FIG. 8 shows the results of examining the intake of Satsuma mandarin juice residue extract effective for recovery of liver function (glutamate / pyruvate transaminase activity (GPT activity) in spontaneously hypertensive rats.

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[Procedure amendment]

[Submission Date] August 8, 2000 (200.8.8)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Claims

[Correction method] Change

[Correction contents]

[Claims]

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 3/06 A23L 2/00 F (72) Inventor Takuya Suzuki 540 Narita, Odawara-shi, Kanagawa Prefecture Meiji Dairy Co., Ltd. Inside the Science Research Institute (72) Inventor Takaji Yajima 540 Narita, Odawara-shi, Kanagawa Prefecture Meiji Dairy Products Co., Ltd. (72) Inventor Kenichi Nakazawa 1-2-1-3 Sakaemachi, Higashimurayama-shi, Tokyo Meiji Dairies Co., Ltd. 72) Inventor Hiroshi Arima 1-21-3, Sakaemachi, Higashimurayama-shi, Tokyo Meiji Dairies Corporation Nutrition Science Research Laboratories (72) Inventor Hideo Hasegawa 1-21-3, Sakaemachi, Higashimurayama-shi, Tokyo Meiji Dairies Corporation Nutrition Science Laboratories ( 72) Inventor Yu Kuwata 1-21-3 Sakaecho, Higashimurayama-shi, Tokyo Meiji Dairies Co., Ltd. F-term (reference) 4B017 LC03 LE10 LG02 LL09 LP01 LP02 4B018 LB08 LE05 MD52 ME12 ME14 MF01 4C088 AB62 AC04 BA09 CA05 CA23 ZA75 ZC33

Claims (6)

[Claims] Claims: 1. Citrus fruit, juice residue, pericarp, mesocarp,
The citrus raw material containing at least one of the carbohydrate membranes is extracted with a polar solvent, and the polar solvent extract is extracted with a pH of 5.5 to 5.5.
8. A composition comprising a soluble fraction adjusted to 8.5 or a processed product thereof. 2. The aqueous extract of citrus fruit juice residue is pH 6
A composition comprising a soluble fraction adjusted to ~ 8 or a processed product thereof. 3. The processed product is at least one of a concentrate, a pasted product, a dried product, an emulsified product, and a dilute product.
The composition according to claim 1, wherein: 4. The composition according to claim 1, wherein the composition is a pharmaceutical type or a food and beverage type composition. 5. The composition of claim 4, wherein the composition is at least one of an antihypertriglyceridemia agent, an antivisceral fat accumulation agent, and an antihepatic function lowering agent. . 6. The food or drink type composition according to claim 4, wherein the composition is a nutritional composition.