JP2000281520A - Composition for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for external use capable of developing excellent antiseptic effect without formulating parabens and having excellent usability and safety by using a specific compound widely used as a perfume solvent in combination with a specific compound widely used as an antiseptic assistant. SOLUTION: The objective composition contains (A) 3-methyl-3- methoxybutanol and (B) 2-phenoxyethanol. The composition is preferably a cosmetic. The amount of the component A is preferably 0.1-10 wt.% based on the total composition and that of the component B is preferably >=0.01 wt.% and as small as possible. The formulating ratio of the components A and B is preferably selected to relatively decrease the amount of a component when the other component is formulated in large amount to effectively exhibit the desired effect. Various cosmetics having excellent antiseptic property as well as excellent usability and safety can be produced by this process without formulating a p-hydroxybenzoic acid ester.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a composition for external use such as cosmetics. In particular, the present invention relates to external compositions such as various cosmetics which are excellent in preservability and also excellent in usability and safety.

[0002]

2. Description of the Related Art A composition for external use such as cosmetics is contaminated by microorganisms adhering to pipes of a production line or the like, is contaminated by bacteria on its surface due to contact with the skin of a finger or the like during use, or around water during use. Contamination from such is inevitable. Therefore, in the composition for external use, usually suppresses the growth of microorganisms,
Paraoxybenzoic acid esters (commonly referred to as parabens) for the purpose of killing these microorganisms and improving the shelf life of the product during storage over time
And other preservatives. Such preservatives such as parabens are used as preservatives in an external composition.
It is excellent in safety and effectiveness.

[0003] However, it is not unforeseen that a very small number of sensitive users may be accompanied by a feeling of irritation during use. In recent years, in particular, there has been a tendency for a composition for external use that is more gentle on the skin to be demanded. It is extremely difficult to completely satisfy the recent demand for external compositions only by blending these parabens as preservatives. I can not deny that side.

In fact, according to our research, it has been found that only a part of users who are sensitive to cosmetics containing the parabens complain of skin irritation. Of course, it is also possible to create a composition for external use that does not contain preservatives such as parabens, but in this case, it is necessary to aseptically produce the composition in order to ensure preservative properties, or to reduce the content and the period of use. Due to the need to use complicated means, such as restricting or using subdivision containers or containers that do not return contents (backless tubes, containers with dispensers, etc.), there is a tendency for lack of economy and versatility Becomes stronger.

[0005]

SUMMARY OF THE INVENTION As a result, the inventor of the present invention has remarkably improved the safety and usability of a user having extremely sensitive skin without causing a feeling of irritation during use. Researches have been conducted to provide a composition for external use which is excellent and does not require special means for ensuring preservative properties. As a result, the present invention was developed. Therefore, an object of the present invention is to provide an external composition which is excellent in preservability and also excellent in usability and safety.
That is, an object of the present invention is to provide an external composition which is excellent in preservability and also excellent in usability and safety.

[0006]

As a result of the above-mentioned research, the present inventor has found that 3-methyl-3-methoxybutanol, which has been widely used as a solubilizing agent for perfume, has been widely used as a preservative aid. By blending in combination with 2-phenoxyethanol which has been used, surprisingly excellent preservative effect is exhibited, and even if the blending amount of parabens or phenoxyethanol is largely reduced, the antiseptic property which can withstand normal use is ensured. I found that I can do it. That is, in the present invention, although both compounds have the use modes as described above, by using both compounds that have not been conventionally used together, an excellent antiseptic effect is exhibited and the antiseptic property is ensured. I found that I can do it.

Further, it has been found that, depending on the amount of the 3-methyl-3-methoxybutanol and 2-phenoxyethanol used in combination, sufficient antiseptic properties can be ensured without the addition of parabens. After confirming that the present invention was excellent, the present invention was completed. That is, the present invention provides a composition for external use, including 3-methyl-3-methoxybutanol and 2-phenoxyethanol, which is excellent in antiseptic properties and excellent in usability and safety, such as various cosmetics.

[0008]

Embodiments of the present invention will be described below. In the present invention, the `` external composition '' is a concept that generally encompasses all compositions used for external use, for example, basic cosmetics, makeup cosmetics, various cosmetics such as hair cosmetics, ointments and the like. It refers to a composition widely applicable to various pharmaceuticals or quasi-drugs. The present invention individually provides the external composition of these embodiments. In the present invention, "preservation" refers to bacteria,
The term "antiseptic" means the resistance to all of these contaminating microorganisms such as mold and yeast.

3-methyl-3-methoxybutanol, which is one of the two essential components to be incorporated in the composition for external use of the present invention (hereinafter referred to as the composition for external use of the present invention), has a structure represented by the following formula. This compound is a component usually compounded in the external composition as one of the solubilizers of the fragrance, and a compound produced by a usual known method can be mixed in the external composition of the present invention. In addition, a commercially available product (such as a product of Kuraray Co., Ltd.) can be blended in the composition for external use of the present invention.

In the composition for external use of the present invention, 3-methyl-
The blending amount of 3-methoxybutanol can be appropriately determined according to the strength of the preservative to be imparted and the blending amount of 2-phenoxyethanol to be combined with this, and is not particularly limited. In order to effectively exert the preservative effect of the composition for external use, it is preferable to mix the composition at a ratio of 0.1% by weight or more based on the total amount of the composition. Although the upper limit of the amount is not particularly limited, it is 10.0% based on the total amount of the composition.
% By weight is sufficient, and the effect cannot be expected to increase even if it is added more than that.

In the composition of the present invention, the above-mentioned 3-methyl-
2-Phenoxyethanol, which is another essential component blended with 3-methoxybutanol, is a compound having a structure represented by the following formula. This 2-phenoxyethanol is a component usually blended in an external composition as a preservative.

[0012]

(Equation 1)

The 2-phenoxyethanol to be incorporated into the composition for external use of the present invention is prepared by an ordinary known method, for example, by reacting phenol with ethylene oxide or reacting sodium phenoxide with ethylene chlorohydrin. -It is possible to mix phenoxyethanol, and it is of course possible to mix commercially available products.

The amount of 2-phenoxyethanol in the composition for external use of the present invention is appropriately determined according to the strength of the antiseptic to be imparted and the amount of 3-methyl-3-methoxybutanol to be added in combination therewith. It is possible to determine, and it is not particularly limited, but in order to effectively exhibit a desired preservative effect, it is preferable to mix the composition for external use in a proportion of 0.01% by weight or more based on the total amount of the external use composition. .

The upper limit of the blending amount of 2-phenoxyethanol is to be appropriately determined according to the properties of the composition for external use, and is not particularly limited. One of the features is that the blending amount of phenoxyethanol can be reduced, so that the blending amount of 2-phenoxyethanol is sensitive to phenoxyethanol which is partially recognized unless the intended effect of the present invention is impaired. It is desirable that the amount be as small as possible from the viewpoint of consideration for the elderly.

[0016] The above-mentioned 3-methyl-3-methoxybutanol and 2-
In general, the blending ratio of phenoxyethanol is such that when one blending amount is set large, the other blending amount is relatively small, and conversely, when one blending amount is set small, the other blending amount is relatively large. It is preferable to perform the desired effects of the present invention effectively.

For example, as shown in an embodiment described later, 3
When the amount of -methyl-3-methoxybutanol is 0.1% by weight or less (excluding 0% by weight) with respect to the total amount of the composition, if 2-phenoxyethanol is added in an amount of 0.5% by weight or more, relatively The effect can be exhibited well. Also, 3
When the amount of -methyl-3-methoxybutanol is more than 0.1% by weight and not more than 1.0% by weight with respect to the total amount of the composition, it is compared with adding 2-phenoxyethanol at least 0.3% by weight. In the case where the effect is more than 1.0% by weight and 3.0% by weight or less, 2%
-When phenoxyethanol is added in an amount of 0.1% by weight or more, the effect can be exhibited relatively well.

When the amount of 3-methyl-3-methoxybutanol is more than 3.0% by weight and not more than 5.0% by weight with respect to the total amount of the composition, 2-phenoxyethanol is added to the same amount as 0.05%. If it is blended in an amount of not less than weight%, the effect can be exhibited relatively well. Further, the amount of 3-methyl-3-methoxybutanol was 5.0% by weight based on the total amount of the composition.
In the case of exceeding 10.0% by weight and exceeding 10.0% by weight, relatively good effects can be exerted when 2-phenoxyethanol is added in an amount of 0.01% or more.

As described above, according to the present invention, 3-methyl-3-methoxybutanol and 2-methylbutanol
By adopting a novel combination of using phenoxyethanol in combination, surprisingly, even without blending preservatives such as parabens, sufficient antiseptic properties can be ensured by blending a small amount of 2-phenoxyethanol, and excellent. An external composition having both usability and safety is provided.

The external use composition of the present invention does not require any additional preservatives or preservatives to be added to the external use composition of the present invention as long as only the intended effects of the present invention described above are intended. However, the addition of other preservatives or preservatives usually used in the composition for external use to the external use composition of the present invention is not prevented as long as the desired effect is not impaired.
That is, in the composition of the present invention, as long as the intended effect is not impaired, depending on the intended properties of the composition for external use, components usually incorporated in the external preparation, for example, humectants, ultraviolet absorbers, vitamins , Animal and plant extracts, anti-inflammatory, whitening,
Of course, vasodilators, astringents, cooling agents, hormonal agents and the like can be blended.

As described above, the composition for external use of the present invention can be widely applied to cosmetics, pharmaceuticals, quasi-drugs and the like which are applied to the outer skin, and the dosage form is aqueous, Solubilizing system, emulsifying system, oil-liquid system, gel system, paste system,
Ointment system, aerosol system, water-oil two-layer system, water-oil-powder 3
A wide range of dosage forms such as a layer system can be adopted. That is, basic cosmetics can be widely applied to various forms such as face wash, lotion, milky lotion, cream, gel, essence (cosmetic), pack, mask and the like.

In addition, hair cosmetics can be widely applied to various forms such as shampoos, rinses, hair styling, hair restorations and the like. Furthermore, in the case of pharmaceuticals or quasi-drugs, it can be widely applied to various ointments and the like. In addition, the dosage form and form which the composition for external use of this invention can take are not limited to these dosage forms and forms.

In such a case, the composition for external use of the present invention may contain widely known base components according to the desired dosage form and form as long as the desired effects of the present invention are not impaired. Can be. That is, liquid fats and oils, solid fats and oils, waxes,
Hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, silicones, various surfactants, sequestering agents, water-soluble polymers, thickeners, various powder components, coloring agents,
A fragrance, water and the like can be appropriately added to the composition for external use of the present invention as needed.

[0024]

EXAMPLES The specific formulation of the composition for external use of the present invention will be described more specifically in the examples described below. However, the present invention is not limited to these examples, and the scope of the invention is not limited thereto. Needless to say, it should be specified by the description. In this example,
"% By weight" or "%" indicating the blending amount means% by weight based on the total amount of the composition unless otherwise specified.

Prior to disclosing the examples, the usability test and the antiseptic judgment test will be described first. <Usability tests> The composition for external use of the present invention was applied to a panel of 30 panelists who complained of skin irritation when using an external composition containing paraben in the past, at a frequency of twice daily in the morning and evening. They were allowed to use for a week, and were asked to report the presence or absence of skin irritation as well as the satisfaction of usability in terms of stickiness and the like.

<Preservative Power Judgment Test> A 30 ml sample was inoculated with a bacterial solution, and the change in the number of bacteria was examined by a smear method. The inoculated bacteria were evaluated for their antiseptic activity by changing the number of bacteria up to 2 weeks using mold, yeast, and bacteria, and the obtained results were classified into the following four-grade criteria. In addition, among the following classifications, those of ◎ or ○ were judged to be acceptable. ：: Immediate effect observed ○: Effect observed △: Little effect observed ×: No effect observed

[Example 1.2 and Comparative Example 1.2] The lotion of Examples 1 and 2 and the makeup of Comparative Examples 1 and 2 as one embodiment of the composition for external use of the present invention having the formulation shown in Table 1 below. Water was subjected to the above-mentioned usability test and preservative evaluation test, and the results are also shown in Table 1. In addition, these lotion production methods followed a method generally used as a lotion production method.

[0028]

[Table 1]

From the results shown in Table 1, it can be seen that in Examples 1 and 2, the percentage of skin irritation that was low and satisfied with usability was high, and preservability was ensured. In Comparative Example 1 in which 2-phenoxyethanol was not added, when the amount of 3-methyl-3-methoxybutanol was small, skin irritation was small, and the proportion of those that satisfied the usability was high, but the preservative was high. He was inferior in power.

On the other hand, as in Comparative Example 1, 2-phenoxyethanol was not blended, but in Comparative Example 2 in which methylparaben was blended, many people complained of skin irritation although they had excellent preservative power. From these results, by combining 3-methyl-3-methoxybutanol and 2-phenoxyethanol, while maintaining the preservative power,
It has been clarified that an external composition having little skin irritation and good usability is provided.

[Examples 3 to 7 and Comparative Example 3.4]
A lotion (in addition to 3-methyl-3-methoxybutanol and 2-phenoxyethanol) in which the blending amounts of 3-methyl-3-methoxybutanol and 2-phenoxyethanol were changed.
The components and amounts other than methyl-3-methoxybutanol and 2-phenoxyethanol are the same as those shown in Table 1 above. ) Was subjected to the preservative test and the usability test described above. 3-methyl-3 for each lotion
Table 2 shows the amounts of -methoxybutanol and 2-phenoxyethanol and the test results.

[0032]

[Table 2]

From the test results in Table 2, 3-methyl-3
In Example 3, in which the content of -methoxybutanol was 0.1% by weight, satisfactory results were obtained when the content of 2-phenoxyethanol was 0.5% by weight. The amount of 3-methyl-3-methoxybutanol was 1.0% by weight.
In Example 4, the content of 2-phenoxyethanol was 0.3% by weight, and satisfactory results were obtained. Similarly, the content of 3-methyl-3-methoxybutanol was 3.0% by weight. In Example 5, satisfactory results were obtained when the amount of 2-phenoxyethanol was 0.1% by weight.

In Example 6 where the amount of 3-methyl-3-methoxybutanol was 5.0% by weight, satisfactory results were obtained when the amount of 2-phenoxyethanol was 0.05% by weight. . Further, 3-methyl-3-
In Example 7 in which the amount of methoxybutanol was 10.0% by weight of the composition for external use, satisfactory results were obtained in both usability and preservative power when the amount of 2-phenoxyethanol was 0.01% by weight. . In addition, Comparative Examples 4 and 5 which did not mix 2-phenoxyethanol at all did not have sufficient preservative power.

From these results, it was found that the mixing ratio of 3-methyl-3-methoxybutanol and 2-phenoxyethanol in the composition for external use of the present invention was such that the mixing amount of 3-methyl-3-methoxybutanol was 0.1% by weight. In the following cases (excluding 0% by weight), it was clarified that relatively good results could be obtained by adding 0.5% by weight or more of 2-phenoxyethanol. Further, if the amount of 3-methyl-3-methoxybutanol exceeds 0.1% by weight, the amount of 1.
When the content was 0% by weight or less, it was revealed that relatively good results could be obtained by adding 0.3% by weight or more of 2-phenoxyethanol.

When the amount of 3-methyl-3-methoxybutanol is more than 1.0% by weight and not more than 3.0% by weight, 2-phenoxyethanol is added in an amount of 0.1% by weight.
It became clear that relatively good results could be obtained by the above mixing. Further, when the amount of 3-methyl-3-methoxybutanol is more than 3.0% by weight and not more than 5.0% by weight, relatively good results can be obtained by adding 0.05% by weight or more of 2-phenoxyethanol. It became clear that was obtained. When the amount of 3-methyl-3-methoxybutanol is more than 5.0% by weight and not more than 10% by weight, relatively good results can be obtained by adding 0.01% by weight or more of 2-phenoxyethanol. It became clear that it could be done.

Examples of the composition for external use of the present invention having various formulations are shown below. In each of the examples, skin irritation was reduced while maintaining excellent antiseptic power, and the usability was good. In addition, the manufacturing method of the composition for external use in these Examples,
The method generally used as the production method for the external composition of each embodiment was followed.

Example 8 Astringent lotion% by weight 3-methyl-3-methoxybutanol 1.0 2-phenoxyethanol 0.3 Polyoxyethylene (POE = 50) oleyl ether 0.5 Polyethylene glycol 300 1.0 Ethyl alcohol 18.0 Dipropylene glycol 2.0 Lactic acid 0.02 50% by weight aqueous solution of sodium lactate 0.25 Trisodium edetate 0.01 Purified water balance

Example 9 Emollient Emulsion Weight% 3-Methyl-3-methoxybutanol 5.0 2-Phenoxyethanol 0.1 Cetanol 1.5 Stearyl Alcohol 1.8 Vaseline 2.0 Dimethylpolysiloxane (20cs) 5 Squalane 2.5 Isopropyl myristate 2.5 Glyceryl monostearate 1.8 Polyoxyethylene (POE = 5) Glyceryl monostearate 1.8 Polyoxyethylene (POE = 20) Cetyl ether 1.5 Carboxyvinyl polymer 0 .25 Potassium hydroxide 0.05 L-arginine 0.2 Glycerin 4.0 Dipropylene glycol 2.0 1,3-butylene glycol 3.0 Trisodium edetate 0.02 Purified water balance

Example 10 Skin Treatment Gel Weight% 3-methyl-3-methoxybutanol 3.0 2-phenoxyethanol 0.3 dimethylpolysiloxane 0.5 isopropyl myristate 1.5 polyoxyethylene (POE = 60) Hardened castor oil 0.5 Tocopherol acetate 0.2 Monoammonium glycyrrhizinate 0.05 Carboxyvinyl polymer 0.45 Potassium hydroxide 0.15 Glycerin 16.0 Dipropylene glycol 2.0 Trisodium edetate 0.01 Purified water residue amount

[0041]

As is clear from the description of the above examples and embodiments of the present invention, the present invention relates to various cosmetics such as basic cosmetics, makeup cosmetics and hair cosmetics, ointments and the like. It is possible to provide an external composition having excellent preservative properties and excellent usability and safety without blending paraoxybenzoate in various external compositions such as pharmaceuticals or quasi-drugs. It has an outstanding effect. As a result, the present invention is superior in safety and effectiveness applicable to users sensitive to parabens.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A01N 39/00 A01N 39/00 Z F term (Reference) 4C083 AB032 AC012 AC022 AC072 AC102 AC122 AC171 AC172 AC182 AC302 AC352 AC422 AC432 AC482 AC532 AC582 AD042 AD092 AD112 AD152 AD532 AD662 CC02 CC04 CC05 DD23 DD27 DD31 DD41 EE12 4H011 AA02 BA06 BB03 DA13 DA17 DG05

Claims (2)

[Claims] 1. An external composition containing 3-methyl-3-methoxybutanol and 2-phenoxyethanol, which is excellent in antiseptic properties and excellent in usability and safety. 2. The external composition according to claim 1, wherein the external composition is a cosmetic.