JP2000256119A - Skin lotion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject preparation which has excellent bleaching effect and is useful as a cosmetic, medicine, or the like by including a thiol compound and octyltriazone as an active ingredient. SOLUTION: This preparation is obtained by including, as active ingredients, (A) preferably 0.001-10.0 wt.% of a thiol compound which is preferably cysteine or a cysteine derivative or the like and (B) preferably 0.001-10.0 wt.% of 2,4,6- trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)-1,3,5-triazine. This preparation is useful as a cleansing preparation, foilet water, milky lotion or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to an external preparation for the skin. More specifically, the present invention provides
The present invention relates to a skin external preparation excellent in skin whitening effect.

[0002]

2. Description of the Related Art According to dermatology in recent years, pigmentation such as spots and freckles on human skin is caused by abnormalities of hormones, irritation caused by exposure to ultraviolet rays, and the like, which causes melanin pigments to be generated in the skin, which is abnormally deposited in the skin. It is being elucidated that this occurs.

[0003] In order to prevent pigmentation such as spots and freckles, an agent for suppressing the production of melanin pigments;
For example, arbutin, ascorbic acid or a derivative thereof,
Skin external preparations in the form of creams, lotions and the like containing kojic acid and the like have been proposed.

[0004]

However, many of these external preparations for skin prevent pigmentation such as spots and freckles induced by irradiation with ultraviolet rays and have a whitening effect such as making the skin fair. It cannot be denied that there is a need for further improvement.

Therefore, an object of the present invention is to provide a skin external preparation having an excellent whitening effect.

[0006]

The inventor of the present invention has made intensive studies to solve this problem, and as a result, surprisingly,
An external preparation for skin containing a thiol compound and octyl triazone is found to have an excellent whitening effect due to a synergistic effect of the thiol compound and octyl triazone,
The present invention has been completed.

That is, the present invention provides a skin external preparation (hereinafter, referred to as a dermal compound) comprising a thiol compound and octyltriazone as active ingredients.
The present invention provides an external preparation for skin).

In the skin preparation for external use of the present invention, when the thiol compound is cysteine or cysteine-inducible, or when it is glutathione or a cysteine derivative, an excellent whitening effect can be exhibited.

[0009]

Embodiments of the present invention will be described below. A. Active Ingredients of the Skin External Preparation of the Present Invention Thiol Compound The skin external preparation of the present invention is a skin external preparation that exhibits a desired effect when combined with a thiol compound and octyltriazone.

The thiol compound blended in the external preparation for skin of the present invention is a compound having an SH group in the molecule. Examples of the thiol compound to be incorporated in the external preparation for skin of the present invention include glutathione such as glutathione, acetylated glutathione, glutathione hydrochloride, glutathione phosphate, glutathione sulfate, and derivatives thereof; cysteine, N
Cysteine such as acetylcysteine, cysteine hydrochloride, cysteine sulfate, cysteine phosphate or a derivative thereof;
Examples include mercaptoacetic acid (thioglycolic acid), mercaptopropionic acid (thiohydroacrylic acid, thiolactic acid), ammonium thiolactate, and monoethanolamine thiolactate.

The thiol compound to be incorporated in the external preparation for skin of the present invention is appropriately selected depending on the specific use of the external preparation for skin, the balance with other components, and the like. In view of the above, glutathione and its derivatives, and cysteine and its derivatives, which are amino acid-based thiol compounds, are preferable, and in particular, glutathione and N-
Acetylcysteine is most preferred.

The external preparation for skin of the present invention may contain one or more of these thiol compounds.

The amount of the thiol compound in the external preparation for skin of the present invention is appropriately selected depending on the specific use of the external preparation for skin, the dosage form, the balance with other components, and the like, and is not particularly limited. Is usually added in the range of 0.001 to 10.0% by weight based on the total amount of the external preparation for skin.
When the amount of the thiol compound is 0.001% by weight or less based on the total amount of the external preparation for skin, the whitening effect of the external preparation for skin tends to be poor, which is not preferable. An increase in the whitening effect cannot be substantially expected, and formulation into an external preparation for skin tends to be difficult due to formulation techniques, which is not preferable.

Octyltriazone The octyltriazone compounded with the thiol compound in the external preparation for skin of the present invention is a substance represented by the following structural formula, and its chemical name is 2,4,6-trianilino-p-.
(Carbo-2'-ethylhexyl-1'-oxy)-
1,3,5-Triazine, which is marketed, for example, by BASF under the trade name Ubinal T150.

[0015]

Embedded image

The amount of octyltriazone in the external preparation for skin of the present invention is appropriately selected according to the specific use of the external preparation for skin, the dosage form, the balance with other components, and the like. However, it is usually added in the range of 0.001 to 10.0% by weight based on the total amount of the external preparation for skin. When the amount of octyltriazone is 0.001% by weight or less based on the total amount of the external preparation for skin, the whitening effect of the external preparation for skin tends to be poor, which is not preferable.
Even if the amount exceeds 0% by weight, an increase in whitening effect cannot be substantially expected.
Incorporation into an external preparation for the skin also tends to be difficult due to formulation techniques, which is not preferred.

As described above, by incorporating a thiol compound and octyltriazone as active ingredients, a skin external preparation having an excellent whitening effect is provided. B. Specific aspects of the external preparation for skin of the present invention In the present invention, `` external preparation for skin '' refers to cosmetics, pharmaceuticals, quasi-drugs, etc. applied to the outer skin, and includes aqueous solutions, solubilizing systems, emulsifying systems, A wide range of dosage forms, such as a powder system, an oil-liquid system, a gel system, an ointment system, an aerosol system, a water-oil two-layer system, a water-oil-powder three-layer system, can be adopted.

For example, when the skin preparation for external use of the present invention is a basic cosmetic, it is used in various dosage forms, such as facial cleanser, lotion, milky lotion, cream, gel, essence (beauty solution), pack mask, and the like. obtain. Further, when the external preparation for skin of the present invention is a makeup cosmetic, it can take a product form such as a foundation. Furthermore, when the external preparation for skin of the present invention is a drug or a quasi-drug, it can take various ointment and other product forms. The skin external preparation of the present invention is not limited to these dosage forms and product forms.

The external preparation for skin of the present invention may further comprise, in addition to the above-mentioned essential components, a thiol compound and octyltriazone, various components usually used for external preparation for skin according to the desired dosage form and product form. It can be blended in a range that does not impair the effects of the invention, and can be manufactured by a conventional method.

Such components include, for example, oils,
UV protection agents, surfactants, thickeners, powder components, humectants, preservatives, sequestering agents, anti-inflammatory agents, activators, blood circulation promoters, antiseborrheic agents, plant extracts, various vitamins, etc. Can be

Examples of the oil component include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, Linseed oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, sinagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin,
Liquid oils such as glycerin trioctanoate and glycerin triisopalmitate; cocoa butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, tallow, sheep fat, hardened tallow, palm kernel oil,
Solid oils such as lard, beef bone fat, mocro kernel oil, hardened oil, beef tallow, mocro, hardened castor oil, etc .; beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, Lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, isopropyl lanolin fatty acid, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether,
POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol,
Waxes such as POE hydrogenated lanolin alcohol ether;
Hydrocarbon oils such as liquid paraffin, ozokerite, squalene, pristane, paraffin, ceresin, squalene, petrolatum, and microcrystalline wax; linear polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane, decamethylpoly Examples thereof include cyclic polysiloxanes such as siloxane, dodecamethylpolysiloxane, and tetramethyltetrahydrogenpolysiloxane, silicone resins forming a three-dimensional network structure, and silicones such as silicone rubber.

Examples of UV protective agents include, for example, monoaminoglycerol ester of paraaminobenzoic acid (hereinafter abbreviated as PABA), ethyl N, N-dipropoxy PABA, ethyl N, N-diethoxy PABA, ethyl N, N-dimethyl PABA , N, N-dimethyl PABA butyl ester, homomenthyl
-N- acetylanthranilate, amyl salicylate,
Menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, octyl cinnamate, ethyl-4-isopropylcinnamate, methyl-2,5-diisopropylcinnamate, ethyl-2,4- Diisopropyl cinnamate, methyl
-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl
-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate,
2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, 3,4,5-trimethoxycinnamic acid 3-
Methyl-4- [methylbis (trimethylsiloxy) silyl]
Butyl, di-paramethoxycinnamic acid-glyceryl mono-2-ethylhexanoate, 2,4-dihydroxybenzophenone,
2,2'-dihydroxy-4-methoxybenzophenone, 2,2 '
-Dihydroxy-4,4'-dimethoxybenzophenone, 2,
2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, 3- (4'-methylbenzylidene ) -dl-camphor, 3-benzylidene-dl-camphor, urocanic acid,
Urocanic acid ethyl ester, 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2 -(2'-Hydroxy-5'-
Methylphenylbenzotriazole, dibenzalazine,
Dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene)-
In addition to organic compounds such as 3-pentan-2-one, inorganic powders such as titanium dioxide, cerium oxide, iron oxide, tungstic acid, bismuth oxide, and composite compounds thereof can be given.

Examples of the surfactant include anionic surfactants, cationic surfactants, amphoteric surfactants, and, for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate. Sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol penta-2-ethylhexylate sorbitan,
Sorbitan fatty acid esters such as diglycerol sorbitan tetra-2-ethylhexylate, glycerin mono-cottonseed oil, glyceryl monoerucate, glyceryl monosteaoleate, glyceryl monostearate, glycerin α, α'-pyroglutamate oleate, glycerin monostearate Lipophilic nonionic interfaces such as glycerin fatty acid esters such as glycerin malate, propylene glycol fatty acid esters such as propylene glycol monostearate, hydrogenated castor oil derivatives, glycerin alkyl ethers and polyoxyethylene methylpolysiloxane copolymers Activator: POE sorbitan monooleate, PO
POE sorbitan fatty acid esters such as E-sorbitan monostearate, POE sorbitan tetraoleate, POE
POE sorbit fatty acid esters such as sorbit monolaurate, POE sorbit monooleate, POE sorbit pentaoleate, POE sorbitol monostearate, POE glycerin monostearate, POE glycerin monoisostearate, POE glycerin triisostearate, etc. POE glycerin fatty acid esters, POE monooleate, POE distearate, POE dioleate,
POE fatty acid esters such as ethylene glycol distearate, POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether,
POE alkyl ethers such as POE 2-octyl dodecyl ether, POE cholestanol ether, POE octyl phenyl ether, POE nonyl phenyl ether, POE alkyl phenyl ethers such as POE dinonyl phenyl ether, pluronic types such as Pluronic, POE PO
P Cetyl ether, POE • POP 2-decyltetradecyl ether, POE • POP monobutyl ether, POE • POP Hydrogenated lanolin, POE • POP Glycerin ether, etc.
POP Tetra POE such as alkyl ethers and tetronic
・ Tetra-POP ethylenediamine condensates, POE castor oil, POE hardened castor oil, POE hardened castor oil monoisostearate, POE hardened castor oil triisostearate, P
POE such as OE hydrogenated castor oil monopyroglutamic acid monoisostearate diester and POE hydrogenated castor oil maleic acid
Castor oil or hydrogenated castor oil derivatives, POE beeswax lanolin derivatives such as POE sorbitol beeswax, alkanolamides such as coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, POE propylene glycol fatty acid ester, POE
Examples thereof include hydrophilic nonionic surfactants such as alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonylphenylformaldehyde condensate, alkylethoxydimethylamine oxide, and trioleyl phosphoric acid.

Examples of the thickener include gum arabic,
Carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose,
CMC, hydroxyethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, PV
A, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium sulfate, xanthan gum, aluminum magnesium silicate, bentonite, hectorite, eicosane diacyl glyceride, etc. Can be

The powder component includes talc, carion, mica, sericite, sericite, muscovite, phlogopite, synthetic mica, biotite, biotite, litthic mica, vermiculite,
Magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (calcium gypsum), calcium phosphate, Fluoroapatite, hydroxyapatite, ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate), inorganic powder such as boron nitride, polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene Powders, organic resin powders such as styrene and acrylic acid copolymer resin powder, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc., and inorganic white such as titanium dioxide, zinc oxide, etc. Fee, iron oxide (red iron oxide),
Inorganic red pigments such as iron titanate, inorganic brown pigments such as γ-iron oxide, inorganic yellow pigments such as yellow iron oxide and loess, and inorganic black pigments such as black iron oxide, carbon black and lower titanium oxide Inorganic purple pigments such as manganese violet, cobalt violet, etc .; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine blue and dark blue; titanium oxide coated mica; titanium oxide coated oxychloride Bismuth, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil, metal powder pigments such as aluminum powder and copper powder, red 201
No., Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405
Organic pigments such as No. 203, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401 and Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230
No. Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3
Organic pigments such as zirconium, barium and aluminum lakes such as No. 1 and Blue No. 1, and natural pigments such as chlorophyll and β-carotene.

Examples of the humectant include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12- Examples include hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, adducts of diglycerin (EO) PO, extracts of Iris brassicae, extracts of Achillea millefolium, and melilot extracts.

Examples of preservatives include methyl paraben, ethyl paraben, butyl paraben and the like.

Examples of the sequestering agent include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, edetate Tetrasodium acid, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid and the like.

Examples of the anti-inflammatory agent include glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, and allantoin.

Examples of the blood circulation promoting agent include nonyl acid valenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, canthari tincture, ittamol, caffeine,
Examples include tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandate, cinnarizine, trazoline, acetylcholine, verapamil, cepharanthin, γ-oryzanol and the like.

Examples of antiseborrheic agents include sulfur, thianthol and the like. As a plant extract, for example,
Oakaku, Clara, Ogon, Ouren, Sicon, Peony, Assemble, Birch, Sage, Loquat, Carrot,
Aloe, mallow, iris, grape, yoquinin,
Loofah, lily, saffron, senkyu, ginger,
Extracts such as Hypericum, Ononis, Rosemary, Garlic, Pepper, Chimney, Touki, Seaweed, Tea and the like.

In addition, raw materials generally used for external preparations for skin, such as fragrance, water, alcohol, etc., can be appropriately compounded as required. In addition, the skin external preparation of the present invention may contain a conventionally known whitening agent such as arbutin, kojic acid, vitamin C or a derivative thereof as long as the effects of the present invention are not impaired.

[0033]

Next, the present invention will be described more specifically with reference to examples. However, the technical scope of the present invention is not limited by the following examples. In addition, about the compounding quantity, unless there is particular notice, it represents the weight% with respect to the object with which the component is mix | blended.

First, the method of testing and evaluating the whitening effect of the external preparation for skin of the present invention (judgment criteria and judgment) will be described. The whitening effect was determined by a use test such as a skin whitening effect by cumulative application, and elimination of pigmentation such as spots and freckles.

[Test Method] As a subject suffering from spots, freckles, etc., one sample was applied to the face every day for three months in the morning and evening for three months, and the whitening effect was examined after three months.
As the samples, the skin external preparations of Examples 1 to 3 and Comparative Examples 1 and 2 prepared using the formulations shown in Table 1 were used,
A whitening effect test was performed. "Table 2" shows the determination results.

[0036]

[Table 1]

[Evaluation Criteria] Significant effect: Pigmentation became almost inconspicuous. Effective: Pigmentation was very thin. Somewhat effective: Pigmentation was slightly lighter. Invalid: No change.

[Judgment] ：: When the ratio (effective rate) showing significant effect and effectiveness among test subjects is 80% or more. ：: When the proportion (effective rate) showing significant effect and effectiveness among test subjects is 50% or more and less than 80%. Δ: When the proportion (effective rate) showing significant effect and effectiveness among test subjects is 30% or more and less than 50%. X: When the ratio (effective rate) showing significant effect and effectiveness among test subjects is less than 30%.

[0039]

[Table 2]

As is apparent from Table 2, the skin external preparation of the present invention containing both glutathione and Ubinal T150 exerts an excellent whitening effect, whereas the skin external preparation of a comparative example containing either one of them. Showed almost no whitening effect, and it was recognized that the combined use of glutathione and Ubinal T150 synergistically increased the whitening effect.

Hereinafter, other examples of the external preparation for skin of the present invention will be described. These skin external preparations were prepared by a conventional method.

Further, when the above-mentioned skin whitening effect test was conducted on these external preparations for skin of the present invention, it was confirmed that all of them exhibited excellent whitening effects.

[Example 4] Emulsion compounding ingredients compounding amount (% by weight) Vaseline 1.0 Liquid paraffin 1.0 Methylpolysiloxane 1.0 Glyceryl trioctanoate 9.0 Cetyl octanoate 5.0 Stearic acid 2.0 Behenine acid 2.0 stearic acid glycerides 2.0 stearyl alcohol 1.0 behenyl alcohol 1.0 carboxyvinyl polymer 0.2 glycerin 8.0 dipropylene glycol 5.0 Uvinul T150 1.0 glutathione 1.0 EDTA · 3Na2H ₂ O 0 .1 Tocopherol acetate 0.1 Neutralizing agent qs Preservative qs Pigment qs Fragrance qs Ion exchange water balance

Example 5 Cream Ingredient Combined with UV Protection Effect Ingredients (% by Weight) Glyceryl Trioctanoate 5.0 Cetyl Octanoate 5.0 Isostearyl Alcohol 3.0 Cyclomethicone 5.0 Isostearic Acid 2.0 Isooctyl methoxycinnamate 5.0 Butyl methoxydibenzoylmethane 2.0 Oxybenzone 1.0 Ethyl cellulose 1.0 Glycerin 10.0 Ethanol 5.0 Ubinal T150 5.0 Glutathione 2.0 EDTA · 3Na2H ₂ O 0.1 Glycyrrhizin Dipotassium acid 0.1 Clara extract 0.1 Ougon extract 0.1 Eicosane diacyl glyceride 0.5 Preservatives qs Pigments qs Fragrance qs Ion exchange water balance

Example 6 Cream Ingredient Combined with UV Protection Effect (Weight%) Phenyltrimethicone 3.0 Octanesancetyl 5.0 Isooctyl methoxycinnamate 7.0 Butylmethoxydibenzoylmethane 1.0 Oxybenzone 1.0 Acrylic acid / alkyl methacrylate copolymer 0.5 Eicosene / vinyl pyrrolidone copolymer 1.0 Carboxyvinyl polymer 0.5 Dipropylene glycol 5.0 Sodium hydroxymethoxybenzophenonesulfonate 1.0 Ubinal T150 0 .01 Glutathione 0.01 Sodium hexametaphosphate 0.1 Acyl glyceride eicosane diacid 0.5 Preservatives appropriate amount Neutralizer appropriate amount Perfume appropriate amount Ion-exchanged water balance

Example 7 Cream Component Having High UV Protection Effect Compounding Amount (% by Weight) Cyclomethicone 10.0 Squalane 1.0 Diisooctyl Succinate 10.0 Isooctyl Methoxycinnamate 5.0 Butylmethoxydibenzoylmethane 2.0 Hydrophobized fine particles titanium dioxide 10.0 Hydrophobized fine particles zinc oxide 10.0 Spherical resin powder 2.0 Talc 2.0 Trimethylsiloxysilicate 3.0 Dimethicone polyol 3.0 Aluminum magnesium silicate 1.0 Distearyldimethylammonium chloride 0.5 Ubinal T150 0.05 Glutathione 0.05 Preservatives qs Pigments qs Flavors qs Deionized water balance

Example 8 Emulsion Component Combined with UV Protection Effect (Weight%) Dimethicone 5.0 Cyclomethicone 5.0 Glyceryl Trioctanoate 10.0 10.0 Pentaerythrit Tetraisooctanoate 10.0 Diisooctyl Succinate 10 1.0 Isostearic acid 1.0 Isooctyl methoxycinnamate 10.0 Dimethicone polyol 1.0 Dimethyl distearyl ammonium hectorite 0.2 1,3 Butylene glycol 10.0 Ubinal T150 0.5 Glutathione 0.5 Preservative Amount Pigment appropriate amount Fragrance appropriate amount Ion-exchanged water balance

Example 9 Sticky Cosmetic Ingredients Compounding Amount (% by Weight) Hardened Oil 2.0 Trimethylolpropane triisooctanoate 20.0 Phenyltrimethicone 10.0 Celesin 5.0 Carnauba wax 3.0 Methoxysilicate Isooctyl cinnamate 8.0 Sericite 20.0 Hydrophobized fine particle titanium dioxide 10.0 Spherical resin powder 20.0 Sorbitan isostearate 1.0 Ubinal T150 0.5 N-acetylcysteine 0.5 Preservatives Appropriate amount Perfume Appropriate amount

Example 10 Ingredients for Daytime Cosmetic Ingredients (Weight%) Octane Sancetyl 5.0 Phenyl Trimethicone 5.0 Diisooctyl Succinate 5.0 Dimethoxycinnamic Acid Isooctanoic Acid Glyceride 1.0 Methoxy Isooctyl cinnamate 2.0 Poly (oxyethylene / oxypropylene) / methyl polysiloxane copolymer 2.0 Dimethyl distearyl ammonium hectorite 1.0 Sodium carboxymethyl cellulose 0.5 Talc 5.0 Ubinal T150 0.5 N -Acetylcysteine 0.1 Preservative qs perfume qs Deionized water balance

Example 11 Ingredients for Intraday Cosmetic Ingredients (Weight%) Stearyl alcohol 2.0 Batyl alcohol 2.0 Pentaerythrit tetraisooctanoate 2.0 Phenyltrimethicone 1.0 Methoxycinnamic acid Isooctyl 8.0 Polyoxyethylene glyceryl isostearate 1.0 Polyoxyethylene glyceryl monostearate 1.0 Glycerin monostearate 1.0 Isostearic acid 1.0 Palmitic acid 2.0 Fine titanium dioxide 3.0 Fine zinc oxide 3 0.0 Bentonite 1.0 Xanthan gum 0.5 Ubinal T150 0.1 Cysteine 0.5 Preservatives qs Neutralizer qs Perfume qs Ion exchange water balance

Example 12 Emulsion-type foundation compounding ingredients (wt%) Talc 3.0 Titanium dioxide 5.0 Bengala 0.4 Iron yellow oxide 1.0 Bentonite 0.5 Polyoxyethylene sorbitan monostearate 2 0.0 Triethanolamine 1.0 Propylene glycol 10.0 Stearic acid 3.0 Isohexadecyl alcohol 7.0 Liquid paraffin 10.0 Ubinal T150 0.1 Cysteine 0.1 Preservatives appropriate amount Perfume appropriate amount Ion-exchanged water residue amount

[Example 13] Oil-based foundation compounding amount (% by weight) Talc 20.0 Kaolin 18.0 Titanium dioxide 10.0 Zinc oxide 3.0 Bengala 1.0 Yellow iron oxide 3.0 Black iron oxide 0 5.5 Solid paraffin 3.0 Microcrystalline wax 6.0 Vaseline 17.0 Isopropyl palmitate 17.0 Ubinal T150 0.001 Glutathione 0.001 Preservatives appropriate amount perfume appropriate amount

[0053]

According to the present invention, an external preparation for skin having an excellent whitening effect can be provided by using glutathione and octyltriazone in combination.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Fumiaki Matsuzaki 1050 Nippacho, Kohoku-ku, Yokohama, Kanagawa Prefecture Inside Shiseido Daiichi Research Center Co., Ltd. (72) Inventor Shun Matsumoto 1050 Nippacho, Kohoku-ku, Yokohama, Kanagawa F-term in the Shiseido Daiichi Research Center Co., Ltd. (reference) AD162 AD172 AD262 AD352 AD411 AD532 AD662 BB01 BB11 CC01 CC02 CC05 CC12 CC19 DD11 DD17 DD21 DD23 DD30 DD31 EE16 EE17

Claims (3)

[Claims] An external preparation for skin containing a thiol compound and octyltriazone as active ingredients. 2. The external preparation for skin according to claim 1, wherein the thiol compound is cysteine or a cysteine derivative. 3. The external preparation for skin according to claim 1, wherein the thiol compound is glutathione or a glutathione derivative.