JP2000168774A - One-piece injection-molded container for pharmaceutical packaging liquids - Google Patents

Abstract

(57) [Summary] [PROBLEMS] To develop a disposable plastic integrally molded container for a liquid medicine packaging solution capable of administering a predetermined amount of a drug. SOLUTION: This is a disposable single-piece sealed plastic container for a liquid medicine, in which a hollow body portion for containing a chemical solution and a cap are connected by a detachable thin film, and a space where the chemical solution enters the cap portion. A disposable plastic integrated injection-molded container for drug-dispensing liquids capable of dispensing a predetermined amount, which is structured such that there is no liquid or it falls down immediately after entering and does not accumulate a drug solution.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a plastic one-piece injection-molded container for disposable divided liquids, which can be administered in a predetermined amount and used for pharmaceuticals.

[0002]

2. Description of the Related Art Plastic containers for internal liquids such as divided liquids have been difficult to put into practical use due to the contamination of the containers with the necessity of sterilization. In particular, plastic ampules were used in Japan in the early 1970s. It was released, and in Germany, a sterilizer was installed in the chemical line of the blow-fill-seal system (BFS system: a system for simultaneous molding, filling and sealing of containers) developed by Fresenius and Brown in 1974. Large-capacity plastic containers for injections have been manufactured.

[0003] This BFS system (PHARM TECH JAPAN v
ol.13 No.8 P.29-40 1997) manufactures plastic containers by heating and melting thermoplastics, molding them into containers using molds, filling them immediately with a liquid content, and sealing them by welding. How to Currently this BFS system is
In addition to cosmetics, drinks, contact lens cleaning agents, etc., it is also widely used in the pharmaceutical field for infusions, eye drops, otolaryngological agents, diagnostic agents, sachets, and large and small volume injections. , Are produced in large quantities. These containers manufactured by the BFS system are composed of a main body portion for containing the contents liquid and a head that is separated and discarded. However, since the blow molding method is used, it is difficult to partially adjust the thickness of the container. When the container is cut and the content liquid is taken out, there is always a structural part in the head that is connected to the hollow space of the main body part, and the content liquid enters the space part of this head and remains. (For example, Japanese Utility Model Application Laid-Open No. 59-196)
No. 423). Therefore, the container using the BFS system has a drawback that the drug solution which has entered the space is not administered and is removed, and is not suitable as a drug for which a precise dose must be ensured. .

[0004] In the case of a suspension, in particular, solids aggregate in the space where the head is cut off, which is not suitable for administration of the suspension.

On the other hand, there has also been proposed a closed container having an integral structure in which a tube main body made of a soft synthetic resin and a stopper are connected by a thin portion (for example, FIG. 3 of the present specification; Japanese Utility Model Laid-Open No. 3-53).
No. 454). However, this closed container has been developed as a toothpaste or paste food product, and has a tapered portion (5) formed integrally with the inner surface (2) of the nozzle tip and the stopper when resealing. Due to the line sealing structure with the surface, sealing performance is poor, and due to internal pressure,
There is a problem that the stopper becomes loose. In addition, there is also a problem that the suspension in the drug solution enters the groove formed by the guide portion or the tapered portion and the container main body, and it is difficult to re-disperse the suspension during taking. Therefore, the container described in the above publication has the above-mentioned BF
Like the container manufactured by the S system, it is not suitable as a container for medicines requiring a predetermined amount of administration.

[0006]

DISCLOSURE OF THE INVENTION The present inventor has conducted intensive studies in order to provide a simple plastic integrally molded container for pharmaceuticals under the above-mentioned circumstances, and as a result, a portion cut off from a hollow body portion for accommodating a drug solution. No chemical solution remains in the
We have succeeded in developing a disposable plastic integrated molding container for packaging liquids that can reliably take a prescribed amount of liquid medicine.

[0007] That is, the present invention relates to a plastic one-piece container for a disposable packaging liquid agent, comprising a hollow body portion for containing a chemical solution, a cap portion formed in contact with one end of the hollow body portion, and the hollow body portion. The cap portion is connected to the cap portion by a detachable thin film, and there is no space for the medicinal solution to enter the cap portion to be detached at the time of taking the medicinal solution, or the medicinal solution has a structure in which the medicinal solution can be immediately dropped and taken out and does not collect. The present invention provides a plastic injection molding container for a liquid medicine packaging liquid medicine, which can be temporarily sealed by covering a separated cap portion with an opening of a hollow body portion, if necessary. An object of the present invention is to provide a plastic integral injection-molded container for a liquid filling agent.

Hereinafter, the present invention will be described in detail. The novel plastic integrated injection molding container for a divided liquid agent according to the present invention has been developed as a product for a pharmaceutical requiring a predetermined amount of administration, and is listed in the following 1) to 3). This is a characteristic technical means in terms of structure and use.

1) The hollow body portion for storing the chemical solution and the cap portion are connected by a detachable thin film, and the surface of the cap portion that comes into contact with the chemical solution has a flat surface and does not structurally store the chemical solution. Has become. For those items that need to be temporarily stored after opening, the cap is placed over the opening of the hollow body to prevent foreign substances from entering and leakage of the chemical solution. 2) The hollow body part and the cap part are molded into a size and shape that can be separated by hand, and the part to be separated is a thin film made of plastic thinner than other parts, keeping airtightness and easily separating. It has a structure. 3) The sealing performance between the opening of the hollow body part and the cap
A groove or a protrusion is provided in a ring on each of the fitting surfaces slidably contacting the outer peripheral surface of the hollow body part opening and the inner peripheral surface of the cap, and the protrusions are accommodated in the grooves at the time of fitting, so that the airtightness is further improved. In addition, the sealing performance can be further ensured.

[0010] The plastic injection molded container for a liquid medicine packaging liquid according to the present invention having the above-mentioned features is used as a liquid medicine container for common cold medicines and antacids, and for a medical medicine. It is suitable as a container for a drug solution such as ambroxol hydrochloride, which is a fungicide, and as a container for a suspension such as aluminum hydroxide gel / magnesium hydroxide in combination drugs. In particular, the drug-packaging liquid container according to the present invention is extremely effective as a suspension agent because no drug solution remains on the head (inside the cap) that is cut off for use (when taking) for opening the container. It becomes a container.

Hereinafter, the present invention will be described in detail with reference to the drawings. FIG. 1 shows an embodiment of a plastic integrated injection-molded container for a drug-packaging liquid according to the present invention,
The hollow body part 2 for storing the chemical solution, the cap 3 for preventing the chemical solution from flowing out, the detachable thin film 4 for engaging the hollow body part 2 and the cap part 3, and the sealing portion for sealing the hollow body part 2 after filling the chemical solution 5 is a cross-sectional view of a plastic container main body 1 made of a plastic container 5;

Although the thin film 4 is a thin film that can be cut with a small force, it is designed to be capable of sufficiently withstanding a load due to transportation or a load due to loading in a final form as a packaging liquid after a chemical solution is stored.

The cap 3 has a large inner diameter, and even if a chemical solution enters, the chemical solution naturally falls as soon as the cap 3 is positioned above the hollow body portion 2 and can be returned to the hollow body portion 2. Has been. In addition, when a part of the drug solution is administered as needed and then sealed and temporarily stored, the cap 3 is slidably fitted into the opening of the hollow body portion 2 so as to be sealed.

FIG. 2 shows a container of the type shown in FIG. 1 in which annular projections 8 and grooves 9 are provided on the outer peripheral surface of the hollow body portion 2 and the inner peripheral surface of the cap 3, and a part of the chemical solution is taken out. When the storage is performed again after sealing again, the sealing property is enhanced by the engagement of the groove 9 and the projection 8. In addition, in each aspect of the plastic-integrated injection-molded container for a pharmaceutical packaging liquid according to the present invention, in order to easily separate or remove the cap 3, it is not possible to provide an appropriately shaped handle at an appropriate location on the outer surface thereof. It is possible.

The plastic-integrated injection-molded container for pharmaceutical packaging liquid according to the present invention exemplified in the above figures is manufactured by simultaneously (continuously) performing injection molding of a container, filling of a chemical solution, and sealing in a molding machine equipped with a sealing structure. It is also technically significant in that it is being converted. First, a mold having a predetermined container shape is set in a molding machine, and a thermoplastic plastic material melted by heating is supplied into the mold to be integrally molded into an unsealed container shape. After cooling the unsealed container to a required temperature, a predetermined amount of the heat-sterilized or filter-sterilized drug solution is filled from the filling port, and the final filling port is sealed 5 by welding or the like to seal the product. It is said. The usage mode of the product filled with the chemical is as follows.

[0016] The thin film 4 connecting the hollow body portion 2 containing the chemical solution and the cap 3 of the plastic integral injection molding container 1 for separating liquid is screwed or torn off to separate the cap 3. After that, the opening of the hollow body portion 2 is turned downward, and if necessary, the hollow body portion is pressed to take out the drug solution from the inside of the hollow body portion 2 and take it. When a part of the medicinal solution is to be taken, the remaining medicinal solution after taking is resealed by press-fitting the cap 3 cut off from the thin film 4 into the opening of the inner plug body portion 2 to re-seal the container. In the case of temporary storage, foreign substances are prevented from being mixed into the liquid packaging container and leakage of the drug solution from the container is prevented.

[0017]

As described in detail above, the plastic integrated injection molding container for a liquid medicine packaging liquid according to the present invention can be opened with one touch by opening the cap for preventing the liquid from flowing out of the hollow body portion for storing the liquid. Can be taken out and taken, and in the case of a medicine that needs to be metered, a predetermined amount of the medicine can be reliably administered because the medicine does not accumulate inside the cap.

When the remaining chemical solution is temporarily stored by appropriately increasing or decreasing, etc., the separated cap is put on the opening of the hollow body portion to reseal it, and foreign matter is not mixed into the container for the packaging solution. Leakage of the drug solution from the container can be prevented. In addition, there is an advantage that the container can be manufactured in one piece at low cost by injection molding using a combination of concave and convex molds using a thermoplastic plastic such as polyethylene or polypropylene.

Further, in the case of a container in which a hollow body portion and a cap, which are conventionally used in the pharmaceutical field, are made separately, it is necessary to sterilize the chemical solution and the container in separate steps. By using the integral injection-molded container of the present invention, the steps of container molding, filling with a chemical solution, and sealing can be performed simultaneously, so that the filling operation is simplified and the effect of reducing the product cost is extremely large. .

[Brief description of the drawings]

FIG. 1 is a cross-sectional view of a plastic integrated injection-molded container for a drug-packaging liquid according to the present invention.

FIG. 2 is a cross-sectional view showing an example in which an annular projection and an annular groove are provided in a portion where a hollow body portion and a cap are fitted in the integrated injection-molded container shown in FIG.

FIG. 3 is a partial sectional view of a conventional sealed container.

[Description of Signs] 1 Container main body 2 Hollow body part 3 Cap 4 Thin film 5 Weld seal 6 Neck of cap 7 Surface in contact with chemical solution 8 Projection 9 Groove

Claims (2)

[Claims] Claims: 1. A sealed plastic container for a disposable liquid dispenser, wherein a hollow body portion for containing a medicinal solution and a medicinal solution having an inner diameter substantially equal to the outer diameter of the hollow body portion are not stored. The hollow body portion and the cap are connected by a detachable thin film, and a predetermined amount of the drug solution is characterized in that the drug solution is not left inside the cap. Plastic one-piece injection molded container for pharmaceutical packaging liquids. 2. A plurality of projections or grooves are provided annularly on the upper outer peripheral surface of the hollow body portion, and a plurality of grooves or projections are provided annularly on the inner periphery of the cap. By
2. The plastic injection-molded container according to claim 1, wherein the sealing property is enhanced.