JP2000084052A - Solution for contact lens - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain disinfecting effect with low toxicity to eyes so as to be safely usable by containing amino acid and/or a viscosity improver with nonionic properties or the like in an aqueous medium together with polylysine serving as a bactericidal component. SOLUTION: Polylysine is used as a bactericidal component. and amino acid and/or a viscosity improver with nonionic properties or the like are contained in a coexistent state in an aqueous medium. The antimicrobial activity of the polylysine is therefore increased, and sufficient disinfecting action can be displayed even if the added quantity of the bactericidal component is low in concentration. The concentration of polylysine is to be 0.00000001-1.0 w/v%, and the concentration of amino acid and/or the tension agent with nonionic properties or the like is to be 0.01-20 w/v%. With this constitution, excellent bactericidal effect can be obtained.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid preparation for contact lenses, and more particularly to a liquid preparation for contact lenses which has an excellent disinfecting effect and is sufficiently safe for eyes and is also suitable for use as a cleaning and preserving liquid for contact lenses. The present invention relates to a solution for contact lenses.

[0002]

2. Description of the Related Art Generally, when a contact lens is worn, proteins, lipids, and other stains derived from tears and eye oils adhere to the contact lens. It is necessary to perform a cleaning operation on the contact lens. In addition, when the contact lens is used continuously, microorganisms such as bacteria attached to the surface of the contact lens may grow while the contact lens is removed from the eyes and stored. However, contact lenses need to be disinfected before wearing them, because infectious diseases such as infections may be brought to the eyes, especially in the case of soft contact lenses. Because of the high risk of infection by bacteria and the like, disinfection before wearing is important.

As a method of disinfecting a contact lens, a heat disinfection method using a boiling disinfectant and a chemical disinfection method using a chemical disinfectant have been mainly adopted. In recent years, the operation using a dedicated boiling apparatus is required, and in recent years, the latter chemical disinfection method has received attention.

[0004] In such a chemical disinfection method, a contact lens solution having a chemical disinfecting effect is used, and the contact lens is immersed in the solution to perform a desired disinfection treatment. However, such a contact lens solution is required to have a high bactericidal effect as a characteristic, and of course, since the contact lens is immersed in the solution for a long time, There is also a need for low ocular toxicity.

However, chlorhexidine, benzalkonium chloride, thimerosal and the like have been proposed as chemical disinfectants used in such a chemical disinfection method (JP-A-52-109953, JP-A-62-109953).
JP-153217, JP-A-63-59960, etc.), but all of them are used at a somewhat high concentration in order to sufficiently exhibit their disinfecting effect. It has been reported that chemical disinfectants are easily adsorbed to contact lenses, especially soft contact lenses, which may cause damage when disinfected contact lenses are worn on the eyes. Journal of Contact Lens Society "34: 267
−276,277−282,1992,35: 219−
225, 1993, 36: 57-61, 1994, 3
7: 35-39, 154-157, 1995).

On the other hand, in order to avoid such a danger, a contact lens solution in which the use concentration of a chemical disinfectant (bactericide) is suppressed to a low level is also considered, with an emphasis on safety to the eyes. It is conceivable, however, that in such a case, the bactericidal action is inevitably reduced. As a result, a sufficient disinfecting or bactericidal effect cannot be obtained, and there is a concern that microorganisms may contaminate the contact lens. is there.

Further, Japanese Patent Application Laid-Open No. 9-10288 and P.
The specification related to CT International Publication No. WO97 / 27879, Japanese Patent Application Laid-Open No. 8-504346, and the like disclose a method for disinfecting a contact lens using a contact lens solution using polylysine as a bactericide. However, even if the contact lens solution used in any of these methods is used with the formulation and composition described therein, it cannot be said that the sterilizing effect is sufficient, and the effect is more effective. There is a need for a contact lens solution that is expensive and safe for the eyes.

[0008]

The present invention has been made in view of the above circumstances, and it is an object of the present invention to solve the above problem, while having sufficient disinfecting effect, low toxicity to the eyes, It is an object of the present invention to provide a contact lens solution that can be used safely.

[0009]

In order to solve the above-mentioned problems, the present inventors have developed a solution for contact lenses,
As a result of intensive studies on various known polymers that are considered to have antibacterial or bactericidal effects in order to be used as a disinfecting component or a bactericidal component, polylysine, which is a polymer of L-lysine, has been And low toxicity to the eyes and sufficient safety to be used as a bactericidal component of a contact lens solution, and a specific bactericide and an amino acid and / or
Alternatively, by combining with a nonionic tonicity agent and allowing both to coexist in the contact lens solution, the antibacterial activity or bactericidal action of such a bactericide can be effectively enhanced. As a result, the present invention has been completed.

That is, the present invention is characterized in that an amino acid and / or a nonionic tonicity agent is contained in an aqueous medium together with polylysine as a bactericidal component in order to solve the above-mentioned problems. The gist of the present invention is a contact lens solution.

[0011] As described above, the contact lens solution according to the present invention exhibits excellent bactericidal action and contains toxicity to the eyes by containing polylysine as an active ingredient for disinfection or sterilization. By being extremely low, the safety is also excellent, and the bactericidal action of the polylysine is effectively enhanced by the coexistence of an amino acid and / or a nonionic tonicity agent. Even at a high concentration, an excellent bactericidal effect is achieved.

According to a preferred embodiment of the contact lens liquid according to the present invention, the bactericidal component polylysine is contained in an amount of 0.0000001 to 1.0 w /.
v%, and the amino acid and / or nonionic tonicity agent is 0.01 to 20 watts.
/ V%.

Particularly, in the present invention, ε-polylysine is preferably used as the polylysine, and the nonionic tonicity agent is selected from the group consisting of glycerin, propylene glycol, and mannitol. At least one selected from the group consisting of glycine and sodium L-glutamate is preferably used as the amino acid to further enhance the bactericidal action of polylysine. Will be made to contribute.

Further, in the contact lens solution according to the present invention, together with the above-mentioned polylysine (bactericidal component) and an amino acid and / or a nonionic tonicity agent,
A buffer is advantageously added and included, so that the disinfecting and germicidal effect of polylysine is more fully developed. In addition, as such a buffer, borate buffer, tris (hydroxymethyl)
An aminomethane buffer, a phosphate buffer, or a citrate buffer is preferably used.

[0015]

In the contact lens solution according to the present invention, polylysine used as a bactericidal component is, as is well known, a polymer of L-lysine. It has about 20 to 50 lysine-binding residues, and is obtained, for example, from L-lysine by a general organic synthesis method, or is made to belong to the genus Streptomyces by utilizing biotechnology. It can be industrially produced by culturing a microorganism belonging thereto.

And, as such polylysine,
There are two types of α-polylysine in which an α-amino group and a carboxyl group are condensed and ε-polylysine in which an ε-amino group and an α-carboxyl group are condensed, among which, in the present invention, , Ε-polylysine will be preferably used. This ε-polylysine has an acute toxicity of LD ₅₀ = 5 g / kg or more and has an essential amino acid L in the body.
-Because it becomes lysine and is digested and absorbed, it is extremely excellent in safety for eyes.

According to the present invention, the polylysine as described above is used as a bactericidal component and the antimicrobial activity of such polylysine is further improved by coexistence of an amino acid and / or a nonionic tonicity agent. Therefore, even if the amount of such a bactericidal component is suppressed to a much lower concentration than in the past,
Even at a concentration of w / v%, a sufficient disinfection action can be exhibited. For this reason, in the present invention, such a bactericidal component is generally used at a concentration of 0.0000001 w / v% or more, preferably 0.0000001 w / v% or more, and more preferably 0.000001 w / v% or more. And the upper limit is generally
1.0 w / v% or less, preferably 0.1 w / v% or less,
More preferably, it will be 0.01 w / v% or less.

Further, according to the present invention, the amino acids to be combined with the polylysine as a bactericidal component described above are preferably low-molecular-weight amino acids having a molecular weight of 70 to 250, for example, alanine, α-aminoadipic acid, α-amino acid.
Aminobutyric acid, α-aminoisobutyric acid, arginine, asparagine, aspartic acid, creatine, glutamic acid,
Glycine, histidine, cystine, lysine, leucine,
Examples thereof include ornithine, phenylalanine, phosphoserine, sarcosine, threonine, cysteine, and the like, and salts thereof. Particularly preferably, sodium L-glutamate and glycine are used.

Similarly, according to the present invention, as the nonionic tonicity agent to be combined with the above-mentioned polylysine as a bactericidal component, various conventionally known ones can be appropriately used. For example, glycerin, propylene glycol, mannitol, polyethylene glycol (average molecular weight: 100 to 400), glucose, diethylene glycol, sorbitol, xylitol, cyclodextrin and the like can be mentioned. As long as it is highly safe, any of them can be used, and among them, they can be used alone or in appropriate combination. Among them, particularly, glycerin, propylene At least one of glycol and mannitol is preferably used.

Furthermore, such amino acids and / or nonionic tonicity agents are also added to adjust the osmotic pressure of the liquid preparation for contact lenses according to the present invention. When the contact lens treated in the liquid preparation is worn on the eye, the contact lens is usually in the range of about 200 to 400 mOsm, which is substantially equal to the physiological osmotic pressure, so as not to cause irritation to the eye. For this purpose, the amino acids and / or nonionic tonicity agents are generally present in the contact lens solution at a concentration of from 0.01 to 20% w / v, preferably from 0.1 to 10% w / v. It will be included.

The pH of the contact lens solution according to the present invention is such that the disinfecting and germicidal effect of the specific bactericidal component is sufficiently exhibited, and when the contact lens treated in the contact lens solution is worn on the eye. The pH may be within a range that does not cause irritation to the eyes.
It will be adjusted to a substantially neutral range of 5-9, preferably pH 6-8. If the pH of such a solution is lower than 5 or higher than 9,
There are problems such as the possibility of irritating the eye and causing damage.

In order to keep the pH of such a liquid preparation for a contact lens effectively and within a safe range for the eyes, at least one kind of buffer is generally added. In the present invention, when wearing the contact lens treated in the contact lens solution to the eye, while preventing irritation to the eye, the disinfecting and sterilizing effect of the specific sterilizing component used in the present invention. For sufficient expression, a buffering agent is suitably added and contained.

The buffer used in the present invention may be appropriately selected from conventionally known various ones and used. In general, a borate buffer, tris (hydroxy Methyl) aminomethane buffers (Tris buffers), phosphate buffers or citrate buffers are preferred. If the content of such a buffer in the contact lens solution is too low, the buffering action imparted to the contact lens solution tends to be insufficient if the content is too low. 05
w / v% or more, preferably 0.1 w / v% or more, and when it is too large, when the contact lens after treatment in the contact lens solution is worn on the eye, From the point where obstacles may occur,
Usually 1.2 w / v% or less, preferably 0.8 w / v%
It is desirable to make the following.

In the liquid preparation for contact lenses according to the present invention, in order to improve the effect of removing dirt such as eye oil attached to the contact lens, in other words, to improve the cleaning effect and to increase the viscosity of the liquid preparation, It is also possible to add further surfactants. As the surfactant, a known cation, anion, or amphoteric can be used in a concentration and type that does not impair the action and effect of the present invention, as long as it has high safety to living organisms and does not affect the contact lens material. And nonionic surfactants can be used.

Further, as other additive components to the contact lens solution according to the present invention, an ionic tonicity agent, a chelating agent, a thickener, a protein removing agent and the like can be mentioned. Any known materials can be used as long as they are safe for the living body and do not adversely affect the material of the contact lens. It is also possible to incorporate them in the solution for contact lenses in combination in a quantitative range that does not inhibit the action and effect of the invention.

In preparing the contact lens solution according to the present invention containing the above-mentioned polylysine (bactericidal component), amino acid and / or nonionic tonicity agent, any special method is required. Not needed,
It can be easily obtained by dissolving each component in a predetermined amount of sterilized purified water as in the case of preparing an ordinary aqueous solution. The contact lens solution thus obtained is transparent and can be subjected to aseptic filtration or the like, if necessary.

When the contact lens is cleaned using the contact lens solution according to the present invention obtained as described above, the following procedure is specifically used. That is, first, the contact lens removed from the eye was placed in a storage case filled with the contact lens solution according to the present invention.
Preservation and disinfection is performed by immersion for minutes to 24 hours, preferably 30 minutes to 4 hours. However, it should be understood that this is merely an example, and the method of caring for a contact lens using the liquid agent of the present invention is not limited to the above-described method.

By a series of operations as described above, the contact lens can be effectively and simply disinfected without using a special device such as a boiling device as in the related art. At the same time, since polylysine, which is a bactericidal component, has high safety for the eyes, even when the contact lens is immersed in the contact lens solution according to the present invention for a long time, it may cause damage to the eyes. It is possible to sterilize contact lenses with high safety.

The type of contact lens to which the contact lens solution according to the present invention is applied is not limited to any particular type. For example, soft contact lenses classified into all types such as low water content, high water content, etc. And the hard contact lens can be a target thereof, and the material of the contact lens and the like are not particularly limited at the time of applying the contact lens solution according to the present invention.

[0030]

EXAMPLES In order to clarify the present invention more specifically, some examples of the present invention will be shown below.
It goes without saying that the present invention is not subject to any restrictions by the description of such embodiments. In addition, in addition to the following examples, the present invention, in addition to the above-described specific description, various changes, corrections, and modifications based on the knowledge of those skilled in the art without departing from the spirit of the present invention. It should be understood that improvements can be made. In addition, all the percentages in the following examples are shown as w / v%.

-Bactericidal effect test-Serratia marcescens (Serratia m.
arcescens: ATCC 13880) or Candida albicans (ATCC 10231). First, for Serratia marcescens, one cultured in soybean casein medium at 33 ° C. for 24 hours was suspended in physiological saline, and then suspended in saline. ⁸ while preparing the test bacteria liquid of cfu / ml, for Candida albicans, those cultured 33 ° C. × 24 hours glucose peptone medium, and suspended in physiological saline, 10 ⁸ cfu / ml of test A bacterial solution was used.

Next, with respect to the contact lens solution to be evaluated for its bactericidal effect, the solution was placed in a sterilized test tube.
0 ml, and further, after adding 0.05 ml of the predetermined one of the test bacterial solutions prepared above, store in a constant temperature water bath at 23 ° C., and after a predetermined time, take out a certain amount thereof. After dilution with sterilized saline, the viable cell count in 1 ml of the sample was measured by the pour plate method. The culture conditions in this pour plate method were as follows. For Serratia marcescens, cultivation at 33 ° C. for 4 days using soybean casein medium was used.
As for the albicans, culturing at 33 ° C. for 4 days using a glucose peptone medium was employed. Then, from the viable cell count obtained in this measurement, after calculating the viable cell count of the solution for contact lens to which the test bacterial solution was added after a specified time, it was converted to logarithmic according to the following formula. The amount of reduced bacteria was determined. Bacteria reduction [logarithmic conversion] = LOG (Bacterial suspension 1 immediately after preparation)
viable cell count per ml) -LOG (viable cell count per 1 ml of bacterial suspension after treatment)

Example 1 The following experiment was conducted to examine the bactericidal efficacy of the contact lens solution according to the present invention. First, according to the following component composition, each additive component was dissolved in sterilized purified water so as to have a designated concentration to prepare a liquid preparation for contact lenses (liquid preparation No. 1). The surfactant is a nonionic surfactant (polyoxyethylene / polyoxypropylene block copolymer), and the polylysine is ε-polylysine (2
5% aqueous solution). Solution No. 1: Disodium hydrogen phosphate / 12 water 0.52% Sodium dihydrogen phosphate / dihydrate 0.08% Tris (hydroxymethyl) aminomethane 0.3% Glycine 0.9% L-glutamic acid Sodium 0.7% EDTA / 2Na 0.05% Nonionic surfactant 0.5% Polylysine 0.001%

Next, the bactericidal efficacy against Serratia marcescens of the liquid No. 1 was examined in accordance with the bactericidal effect test in terms of the amount of bacteria reduced after 4 hours, and the results are shown in Table 1 below.

[0035]

[Table 1]

As is apparent from Table 1, the contact lens solution No. 1 according to the present invention using glycine and sodium L-glutamate as amino acids together with polylysine has an excellent bactericidal effect.

Example 2 In order to examine the bactericidal effect of a solution for contact lenses according to the present invention by combining an amino acid and / or a nonionic tonicity agent and a buffer, the following Tables 2 to 4 were used.
By dissolving each additive component in sterile purified water so as to have the specified concentration so as to have the component composition of the above, various contact lens solutions (solution Nos. 2 to 2)
15) was prepared. For comparison, a liquid preparation for contact lenses not containing polylysine (liquid preparation No. 16)
To 18) were also prepared with the component compositions shown in Table 5 below.

Next, in the same manner as in Example 1, the contact lens liquids of Nos. 2 to 15 according to the present invention and the contact lens liquids of Nos. 16 to 18 as comparative examples were applied to Serratia marcescens. The bactericidal efficacy was examined according to the bactericidal effect test in terms of the amount of reduced bacteria after 4 hours, and the results are shown in Table 6 below.

[0039]

[Table 2]

[0040]

[Table 3]

[0041]

[Table 4]

[0042]

[Table 5]

[0043]

[Table 6]

As is clear from the results of Tables 2 to 5 and 6, in the liquid preparations No. 2 to 15 which are liquid preparations for contact lenses according to the present invention, polylysine which is a bactericidal component contains amino acids and / Or nonionic tonicity agent,
Furthermore, even if a buffer is combined, an excellent bactericidal effect can be obtained. On the other hand, a liquid preparation containing no polylysine as a bactericidal component (Nos. 16 to 18) prepared as a comparative example has no bactericidal effect. Turned out not to be obtained.

Example 3 The following experiment was conducted to examine the bactericidal efficacy of the liquid preparation for contact lenses according to the present invention. First, in the component compositions shown in Table 7 below, various additives for contact lenses were prepared by dissolving each additive component in sterilized purified water so as to have a designated concentration. In addition,
As polylysine, ε-polylysine (25% aqueous solution) manufactured by Chisso Corporation was used in the same manner as in the above examples.

Next, with respect to the various contact lens solutions thus obtained, the bactericidal efficacy against each of Candida albicans and Serratia marcescens was determined in terms of the amount of reduced bacteria after 4 hours according to the bactericidal effect test described above. Investigation and the results are shown in Table 8 below.

[0047]

[Table 7]

[0048]

[Table 8]

As is clear from the results of Tables 7 and 8, in the contact lens liquid preparations Nos. 19 to 21 according to the present invention, glycerin or non-ionic tonicity agent was used as the nonionic tonicity agent. By adding propylene glycol, the sterilizing agent is more germicidal than when such a nonionic tonicity agent is not added (solution Nos. 22 and 24) or when polylysine is not used as a bactericide (solution No. 23). It is recognized that the effect is remarkably excellent.

Example 4 In order to investigate the effect of the type of buffer on the contact lens solution according to the present invention, the following three types of solution (No. 25) were used.
To 27) were prepared in the form of an aqueous solution. Solution No. 25: Boric acid 0.5% Borax 0.11% Glycerin 2.0% ε-Polylysine 0.001% Solution No. 26: Glycerin 2.0% ε-Polylysine 0.001% Dihydrogen phosphate Sodium dihydrate 0.008% Disodium hydrogen phosphate / 12 water 0.52% Solution No. 27: glycerin 2.0% ε-polylysine 0.001% Tris (hydroxymethyl) aminomethane 0.4% HCl appropriate amount

A bactericidal effect test was performed on each of the three types of contact lens liquid preparations for Serratia marcescens, and the amount of reduced bacteria at 2 hours and 4 hours after the test bacteria was determined. Is shown in Table 9 below.

[0052]

[Table 9]

As is clear from the results in Table 9, any one of the borate buffer (solution No. 25), the phosphate buffer (solution No. 26) and the Tris buffer (solution No. 27) was used. Even when a buffer is used, an excellent bactericidal effect is synergistically exerted. In particular, it can be recognized that the effect is remarkable when a borate and a Tris buffer are used.

Example 5 The bactericidal effect of polylysine in a contact lens solution at a low concentration, which was used as a bactericidal component, was evaluated using Staphylococcus aurus as a test bacterium.
eus: ATCC 6538P), and examined in the same manner as in Example 4.
The amount of reduced bacteria after 2 hours and 4 hours was determined.

The concentration of polylysine in the contact lens solution was 0.00001% (solution No. 2).
8), 0.00005% (solution No. 29), 0.000
1% (solution No. 30), boric acid: 0.5%,
It was prepared as an aqueous solution containing borax: 0.11% and glycerin: 2.0%, and the pH was adjusted to 7.2.

The results obtained are shown in Table 10 below, wherein the concentration of polylysine in the contact lens solution was 0.0
Even at a low concentration of 0001%, it was confirmed that the contact lens solution according to the present invention had an excellent bactericidal effect.

[0057]

[Table 10]

Example 6 To examine the effect of other components on the bactericidal effect, polylysine: 0.001%, boric acid: 0.5%, borax:
0.11%, glycerin: 2.0% was dissolved in purified water, and an aqueous solution of pH 7.2 was added to a nonionic surfactant (polyoxyethylene / polyoxypropylene.
(Block polymer): 0.1%, EDTA: 0.05%
To which an aqueous solution (solution No. 31) was added.

Using Serratia marcescens and Candida albicans as test bacteria, the amount of reduced bacteria after 1 hour and 4 hours was examined in the same manner as above. . The results are shown in Table 11 below, and it is recognized that the contact lens solution according to the present invention has an excellent effect on any bacteria.

[0060]

[Table 11]

Example 7 In order to examine the bactericidal effect against mold (fungi), Fusarium solani (ATCC 360) was used as a test bacterium.
31), polylysine: 0.001%, boric acid: 0.1%.
58%, Borax: 0.03%, Propylene glycol:
An aqueous solution (liquid No. 32) prepared by dissolving 1.42% in purified water was prepared. Using this aqueous solution, the amount of reduced bacteria after 2 hours and 4 hours was examined in the same manner as described above.
The results are shown in Table 12 below. The solution for contact lenses according to the present invention, although used at a very low concentration of 0.001% of polylysine, which is a bactericidal component, has a low effect on fungi. Also, it is recognized that there is an excellent effect.

[0062]

[Table 12]

Example 8 The safety of polylysine used as a bactericidal component in the contact lens solution according to the present invention was examined using a contact lens in the following agar overlay test.

Agar overlay test An aqueous solution containing 0.25% of polylysine used in the present invention, or benzalkonium chloride as a comparative example: 0.1%
In 2.0 ml of a test solution consisting of a 1% aqueous solution, one piece of each of commercially available soft contact lenses (manicon, Inc., menicon soft MA and menicon soft S) was used.
It was immersed at room temperature for 18 hours. Next, the immersed soft contact lens is taken out, a soft contact lens is placed on the cell using mouse fibroblast cell line L-929, and it is observed whether or not the cell under the lens is damaged. Cytotoxicity was determined by an agar overlay test. When there is an effect of the toxic substance adsorbed on the soft contact lens, cell melting or neutral red discoloration is observed, and this case is regarded as positive (there is cytotoxicity). It was determined as negative (no cytotoxicity). Neutral red is a dye added to cultured cells and is taken up and stained by living cells, whereas dead cells excrete it.

As a result of the cytotoxicity test using the agar overlay test, the test solution containing polylysine used in the present invention was determined to be negative, and it was confirmed that there was no adsorption to the lens and that it was safe. In the case of the test solution containing benzalkonium chloride of Comparative Example, it was determined to be positive, and it was recognized that there was a problem in its safety.

Example 9 Polylysine: 0.001%, citric acid: 0.015%,
An aqueous solution (solution No. 33) was prepared by dissolving 0.126% of sodium citrate and 1.7% of propylene glycol in purified water. Such an aqueous solution (solution No.
When 33) was used as a washing and rinsing solution, and the contact lens was cleaned by immersing it in artificial tears and cleaning the soiled contact lenses, it was found that the cleaning solution was more effective than the other liquid No. .

[0067]

As is apparent from the above description, the contact lens solution according to the present invention contains polylysine as a bactericidal component and contains an amino acid and / or a nonionic tonicity agent. Further, by being contained, the antibacterial activity of such a polylysine bactericidal component is effectively enhanced, and thus, with a smaller content of the bactericidal component, a sufficient bactericidal effect can be exerted, and safety to the eyes can be exhibited. Thus, it is possible to obtain a liquid preparation for contact lenses having an increased value.

Claims (7)

[Claims] 1. A liquid preparation for contact lenses, wherein an aqueous medium contains an amino acid and / or a nonionic tonicity agent together with polylysine as a bactericidal component. 2. The polylysine according to claim 2, wherein
The liquid preparation for contact lenses according to claim 1, which is contained at a concentration of 1 to 1.0 w / v%. 3. The contact lens solution according to claim 1, wherein the amino acid and / or the nonionic tonicity agent is contained at a concentration of 0.01 to 20% w / v. . 4. The liquid preparation for contact lenses according to claim 1, wherein the polylysine as the bactericidal component is ε-polylysine. 5. The contact lens according to claim 1, wherein the nonionic tonicity agent is at least one selected from the group consisting of glycerin, propylene glycol, and mannitol. Liquid. 6. The solution for contact lenses according to claim 1, wherein the amino acid is a low-molecular-weight amino acid having a molecular weight of 70 to 250. 7. The contact lens liquid preparation according to claim 1, further comprising a buffer.