JP2000084046A - Compound infusion container - Google Patents

Abstract

(57) [Summary] [PROBLEMS] To provide a composite infusion container which can simplify an assembling process, and is excellent in sanitary quarantine, storage and easy disposal. SOLUTION: A sealed flexible container 1 containing a liquid medicine therein and having a sealing portion 5 which can be communicated by external pressure, and at least one other medicine are housed.
A flexible container 6 having at least one side sealed by a weak seal 10 which can be opened by external pressure;
And a communication member 4 for communicating between the weak seal portion 10.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composite infusion container used for drip injection and the like. More specifically, a liquid for dilution or dissolution (in the present invention, referred to as "liquid drug") and another drug (in the present invention, used by mixing or dissolving in a liquid drug) The other drug is referred to as “another drug”.) The drug is separated and stored in a sealed state. During transport and storage, these drugs are kept separate and can be easily operated when used as an infusion infusion container. The present invention relates to a composite infusion container capable of easily dissolving or mixing a drug.

[0002]

2. Description of the Related Art In the medical field, infusion is widely used, and some infusions used for infusion may be mixed with two or more drugs immediately before use. For example, when infusing a powdered drug or a lyophilized drug in a container such as a vial, these are dissolved in a liquid drug and used for infusion as an infusion solution. Since the treatment is performed in an environment such as a hospital room, there is a concern that foreign substances may be mixed in, foreign bacteria may enter, or the like.

[0003] For the purpose of avoiding such danger, various two-drug infusion containers having sanitary epidemiological properties have been developed. These two-drug infusion containers are ones in which a vial drug container and a portable liquid drug container are sealed in a system that is shielded from the outside air. The two drugs are brought into communication and mixed. Such an infusion container is disclosed in JP-A-5-123377 and JP-A-5-1923.
77, JP-A-7-255820 and the like.

[0004]

However, although the danger of invasion of various bacteria has been avoided, the above-mentioned infusion container uses a conventional vial container, so that the number of parts increases and the process of assembling the container becomes complicated. However, there is a problem that the container volume is small due to bulkiness, and that the container body must be disassembled at the time of disposal to separate it into rubber, plastic, glass, and the like. The present invention has been made in view of such a problem, that is, an object of the present invention is to provide a composite infusion container which can simplify an assembling process and is excellent in sanitary quarantine prevention, storage, and easy disposal.

[0005]

According to the present invention, there is provided [1] a sealed flexible container which contains a liquid drug therein and has a sealing portion which can be communicated by external pressure, and A flexible container containing at least one other drug to be used by being mixed with the liquid drug, and having at least one side sealed by a weak seal that can be opened by external pressure; [2] The composite infusion container according to [1], wherein the peripheral portion is a thin-walled plate material except for a thick fulcrum portion having a narrow width. The above objectives have been achieved by developing a complex infusion container.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The contents of the present invention will be described below in detail with reference to the drawings. In FIG. 1, a flexible container 1 is a flexible container for accommodating a liquid drug, and is made of a material having transparency for confirming the contents and heat resistance for sterilizing the retort. Preferred materials include a single polyolefin film, a laminated film of two or more polyolefins, a laminated film of a polyolefin and another synthetic resin, and the like. The method for producing the flexible container 1 is not particularly limited. For example, it is advantageous to cut a tubular film obtained by general inflation molding in plastic molding and seal the upper and lower portions thereof before use. Examples of the liquid drug include physiological saline, glucose solution, distilled water for injection, and various other electrolyte-containing solutions.

[0007] At the bottom of the flexible container 1, a mouth member 2 for filling and taking out, which is mainly made of polyolefin, is adhered to a seal portion 3 of a tubular film. At this time, it is advantageous in terms of cost and performance to perform sealing by heat sealing. On the upper part of the flexible container 1, a communication member 4 mainly made of polyethylene is adhered to the sealing portion 3 of the tubular film.
Also in this case, heat sealing is advantageous in cost and performance.

The communicating member 4 has a sealing portion 5 on one end surface.
The other end face has a flange 11 for connecting to the communication member 7.
Is provided, and the sealing member 5 side of the communication member 4 is inserted into the flexible container 1 and adhered to the flexible container 1. As shown in FIGS. 2 and 3, the sealing portion 5 includes a projection 51 serving as a point of force at the time of pressurization, a thin peripheral portion 52, and a thick fulcrum 53 having a narrow width. When the projection 51 is pressed with a finger or the like during use, the thin peripheral portion 52 is easily broken while leaving the thick fulcrum 53 with a narrow width (FIG. 3). The shape of the cylindrical portion of the communication member 4 may be an elliptical shape other than a cylindrical shape, a rectangular shape, or the like, and is not particularly limited. For filling the flexible container 1, for example, a liquid drug is filled from the mouth member 2 and then sealed with a rubber stopper 13.

The other flexible container 6 is a container for storing another medicine to be used by mixing with a liquid medicine, and may be the same material as the flexible container 1 depending on the kind of the medicine. However, it is usually made of a material having oxygen and water vapor barrier properties to prevent deterioration of the drug. Specifically, a laminated film in which the innermost layer is a polyolefin and a barrier layer is disposed outside the polyolefin is used. Preferred barrier layer materials include ethylene-vinyl alcohol copolymer, polyamide, polyvinylidene chloride, polyester, aluminum foil, silicon oxide, aluminum oxide or aluminum oxide-deposited resin film, and the like. These barrier materials are selected or combined in accordance with one another and used in a laminated manner.

As the flexible container 6, a film obtained by general multilayer inflation molding, multilayer T-die molding, lamination molding or the like used in plastic film molding can be used. At the bottom of the flexible container 6, a communication member 7 mainly composed of polyolefin is bonded to the laminated film in a liquid-tight manner by heat sealing or dry laminating adhesive. The other peripheral portion of the flexible container 6 is also bonded by heat sealing or the like. The communication member 7 is a cylindrical member having a flange 14 for connecting to the communication member 4 of the container 1. Preferably, the communication member 7 uses the communication member 4 without the sealing portion 5. In some cases, the communication member 7 may be omitted, and the communication member 4 may be omitted.
May be connected as they are. The method of manufacturing the mouth member 2, the communication member 4, and the communication member 7 does not need to be particularly limited, but can be obtained by, for example, general injection molding in plastic molding with high productivity.

The flexible container 6 is sealed with a weak seal 10 in order to shield other stored medicines from the outside atmosphere. The sealing strength of the weak seal portion 10 is such that the sealed state is maintained after the other chemicals are sealed, operations such as sterilization and connection of the communication member can be performed in the sealed state, and the flexible container 1 and the flexible container 6 It is necessary to have a peeling strength that allows the flexible container 1 to be easily opened by crushing the flexible container 1 after breaking the sealing portion 5 in order to communicate with the container. The strength may need to be changed slightly depending on the size of the flexible container, the type of the medicine to be enclosed, and the like. Generally, the strength of the liquid medicine in contact with the seal portion is 0.02 to 0.15 kg. / Cm ² is preferably a pressure resistance at which peeling starts when the pressure is increased. A hole 12 for hanging the gantry at the time of drip injection may be provided above the peripheral heat seal of the flexible container 6. It should be noted that the number of storage locations for the other medicines in the flexible container 6 need not be one, and two or more storage locations can be provided as shown in FIG.

As described above, since the flexible container 1 and the flexible container 6 can be handled independently of each other, appropriate sterilization conditions can be selected according to the medicine of each content. That is, the flexible container 1 containing the liquid medicine is subjected to retort sterilization as a high-temperature heat sterilization, while the flexible container 6 containing other medicines is subjected to radiation sterilization when there is a risk of deterioration due to heating. Then, the communication members 4 and 7 of the two may be integrated by welding and connecting the connecting flanges 11 and 14 in a sterile room or the like. Examples of the welding method include butt welding, hot plate welding, impulse welding, high-frequency welding, and ultrasonic welding. From the viewpoint of high-speed productivity, high-frequency welding is particularly preferable. The drug-mixed infusion container filled with a drug or the like only needs to protect this portion with corrugated cardboard or the like in order to ensure the safety of the sealed portion during storage, transportation, and the like. Part 5
1 is pressed to break the sealed state of the sealing portion, and then the portion of the flexible container 1 is pressed to break the sealing of the weak seal 10 and mix the liquid drug with another drug.

[0013]

The composite infusion container of the present invention has a small number of parts, is easy to manufacture, has a structure with good productivity, and ensures that each drug is used until it is used even after filling the drug. In use, mixing can be performed with a simple operation while maintaining a sterile state. Furthermore, it is almost entirely plastic, and is easy to dispose. It is a drug-mixed infusion container having hygienic and epidemic properties, and excellent in storage property before use and disposal property after use.

[Brief description of the drawings]

FIG. 1 is a front view of a composite infusion container of the present invention.

FIG. 2 is an enlarged view of a communication member sealing portion on a liquid side of a medicine.

FIG. 3 shows a state in which a sealing portion of the communication member of FIG. 2 is broken.

FIG. 4 is a front view of a flexible container for two other medicaments.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Flexible container 2 Mouth member 3 Heat seal part 4 Communication member 5 Sealing part 51 Projection part 52 Thin part 53 Thick fulcrum part 6 Flexible container 7 Communication member 8 Heat seal part 10 Weak seal part 11 Flange 12 Hanging Hole for lowering 13 Rubber stopper 14 Flange

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Akihiko Sakata 3-2-2 Chidori-cho, Kawasaki-ku, Kawasaki-ku, Kawasaki, Kanagawa Prefecture (72) Inventor Junji Yotsuyanagi Chidori, Kawasaki-ku, Kawasaki-shi, Kanagawa Kawasaki Laboratory, Research Institute, Showa Denko KK

Claims (2)

[Claims] 1. A liquid container containing a liquid medicine therein, a sealed flexible container having a sealing portion which can be communicated by external pressure, and at least a liquid container used for mixing with the liquid medicine. It comprises a flexible container containing at least one other drug, at least one side of which is sealed with a weak seal that can be opened by external pressure, and a communication member that communicates between the sealing portion and the weak seal portion. Complex infusion container. 2. The composite infusion container according to claim 1, wherein a peripheral portion of the composite infusion container is formed of a thin-walled plate member except for a thick fulcrum portion having a narrow width.