JP2000084041A - How to store cataplasm - Google Patents

Abstract

(57) [Problem] To provide a method for preventing discoloration due to oxidation and reduction in medicinal effect and for storing a cataplasm for a long period of time. SOLUTION: A packaging bag having a gas barrier property is filled with a cataplasm together with an oxygen scavenger, sealed, and the cataplasm is stored. Alternatively, an oxygen-permeable layer (1) made of an oxygen-permeable thermoplastic resin and an oxygen-absorbing resin composition obtained by mixing a deoxidizer composition with a thermoplastic resin are provided on at least a part of a packaging bag having gas barrier properties. A packaging bag in which an oxygen-absorbing multilayer film in which each layer of an oxygen-absorbing layer (2) and a gas barrier layer (3) made of a gas-barrier material is sequentially laminated is disposed with the oxygen-absorbing layer (1) inside the packaging bag. Use to store the cataplasm. [Effect] It is possible to prevent oxidation of the active ingredients such as the plaster and essential oil component of the poultice, prevent discoloration of the plaster surface and decrease of the medicinal effect, and allow the poultice to be stored for a long period of time.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to discoloration due to oxidation,
The present invention relates to a method for preventing a decrease in medicinal effect and storing a cataplasm.

[0002]

2. Description of the Related Art A cataplasm is a thick paste-form preparation usually prepared for immediate application to the skin, which is intended to reduce inflammation and relieve pain.
Widely used for muscle pain, joint pain, fracture pain, etc. Previously, paste-form preparations were spread on lint cloth or the like before use, then covered with a waterproof cloth, oil paper, or a polyolefin-based film, and then applied to the affected area. The mixture is mixed with a plaster base mainly composed of a water-soluble polymer with high water retention, spread on a support such as a non-woven fabric, and the plaster surface is covered with a polyolefin-based plastic film. Molded cataplasms, which are cut into preparations and can be easily applied to the affected area, have become mainstream.

[0003] The present preparation of a poultice is usually prepared by mixing an active ingredient such as a powder of a drug and an essential oil component into a plaster mainly composed of a water-soluble polymer. Examples of the active ingredient include dl-camphor, mint oil, borneol, eucalyptus oil, or l-menthol, which have a local stimulating action, and salicylic acid derivatives such as methyl salicylate and glycol salicylate, which are absorbed percutaneously to exhibit anti-inflammatory analgesic action, and ketoprofen. is there. Formulations containing these are called cold sensation types in anticipation of the cooling effect of water, and are widely used for acute inflammatory diseases. On the other hand, since the pepper extract or the nonylate wanirilamide stimulates the warming point of the skin, a preparation containing them is generally called a warming type and is used for chronic diseases or inflammatory diseases after remission of swelling. More recently, there is a cataplasm as a cosmetic preparation containing vitamin E, a fragrance, and a pigment having a cosmetic effect.

[0004]

Conventionally, when storing a mud-like cataplasm spread on a cloth at the time of use, the lid was tightly closed in a wide-mouthed can so as to be safe for heating and easy to take out.
In recent years, however, molding cataplasms have become mainstream, and in many cases, they have been hermetically packaged with a gas and water vapor barrier film such as an aluminum foil laminated film to prevent moisture absorption or drying. However, although it is possible to prevent moisture absorption or drying in the packaging form, it is oxidized by oxygen in the packaging bag or a little oxygen mixed into the mixture when the medicine is mixed with the plaster, and discoloration and There is a problem that the medicinal effect is reduced.

An object of the present invention is to remove oxygen contained in a bag or oxygen mixed when a drug is mixed into a plaster, thereby suppressing the oxidation of chemicals and essential oil components in the plaster, and preventing discoloration and medicinal effects. An object of the present invention is to provide a method for preserving a cataplasm that is not deteriorated and is hygienic and easy to handle.

[0006]

SUMMARY OF THE INVENTION The present invention is directed to a method of filling a gas barrier packaging bag with a cataplasm together with an oxygen scavenger, sealing and storing the cataplasm, and at least one of the gas bag packaging bags. An oxygen-permeable layer (1) composed of an oxygen-permeable thermoplastic resin, an oxygen-absorbent layer (2) composed of an oxygen-absorbent resin composition obtained by blending an iron-based deoxidizer composition with the thermoplastic resin, and a gas barrier. An oxygen-absorbing multilayer film, in which each layer of a gas barrier layer (3) made of a conductive material is sequentially laminated, stores a cataplasm using a packaging bag in which the oxygen-absorbing layer (1) is arranged inside the packaging bag. On how to do.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in more detail. The packaging bag having gas barrier properties used in the present invention is a metal foil such as an aluminum foil, a metal such as aluminum, aluminum oxide, or silicon oxide, or a resin film on which a metal oxide is deposited, nylon such as MXD6, ethylene-vinyl alcohol, or the like. It is preferably made of a resin such as a copolymer, polyvinylidene chloride, and a resin film, and may be laminated with another resin if necessary. The oxygen permeability of the packaging bag is 5
0 cc / m ² · atm · day or less is preferable, and 25 c
c / m ² · atm · day or less is more preferable.

[0008] As the oxygen absorber used in the present invention, an oxygen absorber in a small bag containing a granular or powdery oxygen absorber composition in a small air-permeable bag is used. Alternatively, a sheet-type oxygen absorber obtained by kneading the oxygen-absorbing composition with a resin and then stretching, preferably, a label-type oxygen-absorbing agent containing the sheet-shaped oxygen absorber in a gas-permeable small bag equipped with an adhesive tape. An oxygen agent is used.

As the oxygen scavenger composition, a composition in which iron powder is a main component and a metal halide is blended as an oxygen absorption promoter is preferably used. As the iron powder, for example, spray iron powder, sea surface iron powder, electrolytic iron powder, iron grinding powder, crushed iron, etc. are used. The content of oxygen and silicon as impurities is small, and the metal iron content is 95% by weight or more. Iron powder is particularly preferably used.
The metal halide is preferably an alkali metal or alkaline earth metal chloride, bromide or iodide.
In the present invention, after mixing an aqueous metal halide solution with iron powder,
Iron powder coated with an alkyl metal halide or an alkyl earth metal halide, which is adjusted by drying to remove water, is preferably used.

The oxygen-absorbing multilayer film used in the packaging bag of the present invention comprises an oxygen-permeable layer (1) made of an oxygen-absorbing thermoplastic resin, and an oxygen-absorbing layer obtained by blending an iron-based oxygen scavenger composition with the thermoplastic resin. This is an oxygen-absorbing multilayer film in which respective layers of an oxygen-absorbing layer (2) made of a resin composition and a gas barrier layer (3) made of a gas-barrier material are sequentially laminated.

Examples of the resin used for the oxygen permeable layer (1) include polyolefins such as polyethylene, polypropylene and polymethylpentene, polystyrenes such as polystyrene and modified products thereof, EVA, EMMA, EAA.
And thermoplastic resins such as elastomers. These resins are used singly or in an appropriate blend.

As the oxygen scavenger composition used in the oxygen absorbing layer (2), iron powder coated with the above-mentioned alkyl halide metal or alkyl earth metal halide is preferably used. In addition, it is preferable that the particle diameter of iron powder is selected in the range of an average particle diameter of 1 to 50 μm.

As the thermoplastic resin used for the oxygen absorbing layer (2), various resins used for the oxygen permeable layer (1) are preferable. Further, various additives such as alkaline earth metal oxide, activated carbon, zeolite, and titanium oxide can be added to the oxygen-absorbing layer (2) to the iron-based deoxidizing agent.

As the gas barrier layer (3), a metal foil such as an aluminum foil, a resin film on which a metal or metal oxide of aluminum, aluminum oxide or silicon oxide is deposited, nylon such as MXD6, ethylene-vinyl alcohol copolymer, poly A vinylidene chloride-coated film or the like is suitably used, and may be stretched as necessary or composited with another resin by lamination or the like as long as the gas barrier properties are not impaired.

The poultice to be preserved in the present invention is a mixture of a powdered chemical of an active ingredient and an essential oil component in a plaster base mainly composed of a water-soluble polymer, and spread on a support such as a nonwoven fabric.
A preparation in which the plaster surface is coated with a polyolefin-based plastic film and cut into a size that is easy to use, and is used for the purpose of reducing inflammation and pain in diseased parts. It is also used for formulations containing vitamin E, fragrances or pigments with cosmetic effects.

The active ingredients of the cataplasm include dl-camphor, mint oil, borneol, eucalyptus oil or l-menthol, which have a local stimulating action, and methyl salicylate, glycol salicylate, etc., which are percutaneously absorbed and exhibit anti-inflammatory analgesic action. Salicylic acid derivatives, ketoprofen, etc.,
Preparations containing these are widely used as cold-sensation types in diseases of the acute inflammatory phase. There are also pepper extract or nonylate vanillylamide which stimulates the warming point, and preparations containing these are usually used as a warming type for chronic diseases or inflammatory diseases after remission of swelling. Further, there are those containing dl-α-tocopherol acetate in anticipation of a peripheral circulation promoting action and those containing diphenhydramine salicylate, chlorpheniramine maleate, and ammonium glycyrrhizinate for the purpose of anti-inflammatory. In addition, there is a formulation containing a funnel extract under local anesthesia and a powdered oat powder contained therein.

The cataplasm needs to prevent moisture absorption or drying depending on the properties of the cataplasm, and is usually airtightly packaged and stored in a gas and water vapor barrier film such as an aluminum foil laminated film. However, even if the packaging bag can prevent moisture absorption or drying of the preparation, it is oxidized by oxygen in the packaging bag or oxygen entering when the active ingredients such as powdered chemicals and essential oil components are mixed into the plaster. However, there is a problem that discoloration of the preparation and reduction of the medicinal effect occur.

The present invention is directed to a method for filling and sealing a cataplasm together with a deoxidizing agent in a packaging bag having gas barrier properties and storing the cataplasm. Preferably, at least a part of the packaging bag contains an oxygen-absorbing multilayer film. Is used to store a cataplasm by using a packaging bag having a deoxidizing function, which is used by disposing an oxygen-permeable layer (1) inside the packaging bag. It is a hygienic and easy-to-handle storage method that prevents oxidative deterioration due to oxygen entering when mixed with water, and does not cause discoloration or decrease in medicinal effect even when stored for a long time.

[0019]

EXAMPLES The present invention will be described in more detail with reference to examples. Note that the present invention is not necessarily limited to the embodiments. [Example 1] PET / nylon 6 / aluminum foil / LDPE
In a packaging bag (9 x 6 cm) made of a gas and a film having a water vapor barrier property, and a small bag filled with iron-based oxygen absorber (trade name: Z-20PT; self-reactive type, manufactured by Mitsubishi Gas Chemical Co., Ltd.) And filled with an agent (trade name: Salonpas A ^e , manufactured by Hisamitsu Pharmaceutical Co., Ltd.), and the LDPE layer was heat-sealed and sealed (air volume in bag: 80 cc), and 23 ° C. RH
Stored under 50%. Three months later, when the package was opened, no discoloration of the molded cataplasm was observed, and even when the composition was applied to the affected part, the medicinal effect was not reduced and the cataplasm was well preserved.

Example 2 An iron-based oxygen scavenger composition was kneaded with a resin in a packaging bag (19 × 12 cm) made of a film having a gas and water vapor barrier property consisting of PET / nylon 6 / aluminum foil / LDPE. Label type oxygen absorber (trade name: F) which is formed into a sheet and stretched and stored in a small air-permeable bag
L20: Moisture dependent type, filled with a molding cataplasm (trade name: Sankyo Ship, Reed Chemical Co., Ltd.) together with Mitsubishi Gas Chemical Co., Ltd., sealed by heat sealing (air volume in bag: 100 cc), 23 Stored under 50% RH. Three months later, when the package was opened, no discoloration of the molded cataplasm was observed, and even when the composition was applied to the affected part, the medicinal effect was not reduced and the cataplasm was well preserved.

Example 3 An oxygen-permeable layer (1) made of linear low-density polyethylene and having a thickness of 40 μm, an oxygen scavenger composition (iron powder coated with 2% calcium chloride, average particle size 30 μm)
Oxygen-absorbing layer (2) made of low-density polyethylene having a thickness of 30 μm, aluminum foil laminated on layer (2) side /
A packaging bag (7.) in which an oxygen-absorbing multilayer film formed by sequentially laminating each layer of a 34 μm-thick gas barrier layer (3) made of nylon 6 / PET with the oxygen-permeable layer (1) inside the packaging bag. 4 x 4.8 cm), molded cataplasm (trade name: Salonpass 30 hot, Hisamitsu Pharmaceutical Co., Ltd.)
And sealed with heat seal (air volume in bag: 30cc)
And stored at 23 ° C. under 50% RH. Three months later, when the package was opened, no discoloration of the molded cataplasm was observed, and even when the composition was applied to the affected part, the medicinal effect was not reduced and the cataplasm was well preserved.

[0022]

According to the preservation method of the cataplasm of the present invention, the oxygen in the packaging bag and the oxygen mixed in the admixture of the drug and the plaster are efficiently removed by using an oxygen scavenger or an oxygen-absorbing multilayer film. This prevents oxidation of active ingredients such as chemicals and essential oil components in the plaster by oxidation. As a result, discoloration of the poultice and deterioration of its medicinal effect are prevented, and the poultice can be favorably stored for a long time. The cataplasm package of the present invention is characterized in that discoloration of the cataplasm and deterioration of its efficacy due to oxidation are prevented, and that the cataplasm is hygienic and easy to handle.

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 3E067 AA04 AB81 BA12A BB09A BB11A BB12A BB14A BB15A BB18A BB22A BB25A CA04 CA24 EA06 EE25 FA01 FC01 GB13 GD01 GD07

Claims (4)

[Claims] 1. A method for filling, sealing, and storing a cataplasm in a packaging bag having gas barrier properties, wherein the cataplasm is filled together with an oxygen scavenger. 2. A method for filling, sealing and storing a cataplasm in a packaging bag having a gas barrier property, wherein at least a part of the packaging bag having the gas barrier property comprises an oxygen-permeable thermoplastic resin. Each layer of a permeable layer (1), an oxygen-absorbing layer (2) made of an oxygen-absorbing resin composition in which an iron-based oxygen-absorbing composition is mixed with a thermoplastic resin, and a gas barrier layer (3) made of a gas-barrier material are sequentially laminated. A method for preserving a cataplasm, comprising a packaging bag formed of an oxygen-absorbing multilayer film and having the oxygen-permeable layer (1) disposed inside the packaging bag. 3. A package obtained by filling and sealing a packing bag having a gas barrier property with a cataplasm, wherein the cataplasm is filled together with a deoxidizing agent. 4. A package formed by filling and sealing a packing bag having a gas barrier property with a cataplasm, wherein at least a part of the packaging bag having a gas barrier property is formed of an oxygen-permeable thermoplastic resin. Each layer of a permeable layer (1), an oxygen-absorbing layer (2) made of an oxygen-absorbing resin composition in which an iron-based oxygen-absorbing composition is mixed with a thermoplastic resin, and a gas barrier layer (3) made of a gas-barrier material are sequentially laminated. A package for a cataplasm, comprising: a packaging bag comprising an oxygen-absorbing multi-layered film and an oxygen-permeable layer (1) disposed inside the packaging bag.