JO3040B1 - ترايازولوبيريدينات - Google Patents
ترايازولوبيريديناتInfo
- Publication number
- JO3040B1 JO3040B1 JOP/2012/0093A JOP20120093A JO3040B1 JO 3040 B1 JO3040 B1 JO 3040B1 JO P20120093 A JOP20120093 A JO P20120093A JO 3040 B1 JO3040 B1 JO 3040B1
- Authority
- JO
- Jordan
- Prior art keywords
- compounds
- triazolopyridines
- prophylaxis
- disease
- preparing
- Prior art date
Links
- 150000008523 triazolopyridines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
يتعلق الاختراع الحالي بمركبات triazolopyridine من الصيغة العامة (I): (I) حيث R1، R2، R3، R4، وR5 كما هو موضح في الوصف وفي عناصر الحماية، بطرق لتحضير المركبات المذكورة، بتركيبات دوائية واتحادات تشمل المركبات المذكورة، باستخدام المركبات المذكورة لتصنيع تركيبة دوائية لمعالجة أو الوقاية من مرض، بالإضافة إلى مركبات وسطية مفيدة في تحضير المركبات المذكورة.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11163342 | 2011-04-21 | ||
| EP11167872 | 2011-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3040B1 true JO3040B1 (ar) | 2016-09-05 |
Family
ID=46124297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2012/0093A JO3040B1 (ar) | 2011-04-21 | 2012-04-18 | ترايازولوبيريدينات |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US20140120087A1 (ar) |
| EP (1) | EP2699575B1 (ar) |
| JP (1) | JP5989091B2 (ar) |
| KR (1) | KR20140025470A (ar) |
| CN (1) | CN103608350B (ar) |
| AP (1) | AP3491A (ar) |
| AR (1) | AR086191A1 (ar) |
| AU (1) | AU2012244859B2 (ar) |
| CA (1) | CA2833657A1 (ar) |
| CL (1) | CL2013003044A1 (ar) |
| CO (1) | CO6801751A2 (ar) |
| CR (1) | CR20130539A (ar) |
| CY (1) | CY1116439T1 (ar) |
| DK (1) | DK2699575T3 (ar) |
| DO (1) | DOP2013000244A (ar) |
| EA (1) | EA023766B1 (ar) |
| EC (1) | ECSP13013011A (ar) |
| ES (1) | ES2539265T3 (ar) |
| GT (1) | GT201300254A (ar) |
| HR (1) | HRP20150517T1 (ar) |
| HU (1) | HUE025496T2 (ar) |
| IL (1) | IL228704A0 (ar) |
| JO (1) | JO3040B1 (ar) |
| MA (1) | MA35049B1 (ar) |
| ME (1) | ME02143B (ar) |
| MX (1) | MX348783B (ar) |
| MY (1) | MY164939A (ar) |
| PE (1) | PE20141351A1 (ar) |
| PH (1) | PH12013502169A1 (ar) |
| PL (1) | PL2699575T3 (ar) |
| PT (1) | PT2699575E (ar) |
| RS (1) | RS54044B1 (ar) |
| SA (1) | SA112330466B1 (ar) |
| SG (1) | SG194003A1 (ar) |
| SI (1) | SI2699575T1 (ar) |
| TW (1) | TWI558703B (ar) |
| UY (1) | UY34034A (ar) |
| WO (1) | WO2012143329A1 (ar) |
| ZA (1) | ZA201308707B (ar) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9006229B2 (en) | 2011-04-21 | 2015-04-14 | Gilead Sciences, Inc. | Benzothiazole compounds and their pharmaceutical use |
| UA112096C2 (uk) * | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
| WO2013103738A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| CN104284896B (zh) | 2012-03-14 | 2016-06-01 | 拜耳知识产权有限责任公司 | 取代的咪唑并哒嗪 |
| JP6238979B2 (ja) * | 2012-07-10 | 2017-11-29 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換トリアゾロピリジンを調製する方法 |
| WO2014020043A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| WO2014020041A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| WO2014195276A1 (en) * | 2013-06-07 | 2014-12-11 | Bayer Pharma Aktiengesellschaft | Substituted triazolopyridines having activity as mps-1 inhibitors |
| EP3004092B1 (en) * | 2013-06-07 | 2017-03-22 | Bayer Pharma Aktiengesellschaft | Substituted triazolopyridines |
| JP2016521737A (ja) * | 2013-06-10 | 2016-07-25 | バイエル・ファルマ・アクティエンゲゼルシャフト | 癌を治療するための新規な化合物 |
| MA38656A1 (fr) * | 2013-06-11 | 2018-05-31 | Bayer Pharma AG | Combinaisons pour le traitement du cancer comprenant un inhibiteur de la kinase mps-1 et un inhibiteur de la mitose |
| AP2015008898A0 (en) | 2013-06-11 | 2015-12-31 | Bayer Pharma AG | Prodrug derivatives of substituted triazolopyridines |
| EP2860177A3 (en) | 2013-09-20 | 2015-06-10 | Bayer Intellectual Property GmbH | Synthesis of functionalized arenes |
| HUE064630T2 (hu) | 2015-04-17 | 2024-04-28 | Crossfire Oncology Holding B V | Prognosztikai biomarkerek TTK-inhibitoros kemoterápiához |
| MX393395B (es) * | 2017-03-16 | 2025-03-24 | Jiangsu Hengrui Medicine Co | Derivado de heteroaril[4,3-c]pirimidina-5-amina, método de preparación del mismo y usos médicos del mismo. |
| US20230086702A1 (en) | 2019-04-18 | 2023-03-23 | The Johns Hopkins University | Substituted 2-amino-pyrazolyl-[1,2,4]triazolo[1,5a]pyridine derivatives and use thereof |
| CN114302878A (zh) | 2019-07-03 | 2022-04-08 | 大日本住友制药肿瘤公司 | 酪氨酸激酶非受体1(tnk1)抑制剂及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| ES2315909T3 (es) | 2004-08-17 | 2009-04-01 | GALDERMA RESEARCH & DEVELOPMENT | Nuevos compuestos bioaromaticos que son activadores de los receptores del tipo ppar y su utilizacion en composiciones cosmeticas y farmaceuticas. |
| BRPI0716239A2 (pt) | 2006-08-30 | 2013-08-13 | Cellzome Ltd | derivados de triazol como inibidores de cinase |
| EP2178868A1 (en) * | 2007-07-18 | 2010-04-28 | Novartis Ag | Bicyclic heteroaryl compounds and their use as kinase inhibitors |
| NZ584138A (en) | 2007-08-23 | 2011-10-28 | Astrazeneca Ab | 2-anilinopurin-8-ones as inhibitors of ttk/mps1 for the treatment of proliferative disorders |
| MX2010002312A (es) * | 2007-08-31 | 2010-03-18 | Merck Serono Sa | Compuestos de triazolopiridina y su uso como inhibidores de cinasa reguladora de señal de apoptosis. |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| JP2011504900A (ja) * | 2007-11-27 | 2011-02-17 | セルゾーム リミティッド | Ｐｉ３ｋ阻害剤としてのアミノトリアゾール |
| WO2010092041A1 (en) * | 2009-02-13 | 2010-08-19 | Fovea Pharmaceuticals Sa | [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors |
| CA2760077A1 (en) | 2009-04-29 | 2010-11-04 | Marcus Koppitz | Substituted imidazoquinoxalines |
| CN102596932A (zh) | 2009-09-04 | 2012-07-18 | 拜耳医药股份有限公司 | 作为酪氨酸苏氨酸激酶抑制剂的取代氨基喹喔啉 |
| EP2343297A1 (en) * | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
| UY33452A (es) * | 2010-06-16 | 2012-01-31 | Bayer Schering Pharma Ag | Triazolopiridinas sustituidas |
-
2012
- 2012-04-16 EA EA201301181A patent/EA023766B1/ru not_active IP Right Cessation
- 2012-04-16 DK DK12721779.2T patent/DK2699575T3/da active
- 2012-04-16 MA MA36344A patent/MA35049B1/fr unknown
- 2012-04-16 RS RS20150345A patent/RS54044B1/sr unknown
- 2012-04-16 ME MEP-2015-80A patent/ME02143B/me unknown
- 2012-04-16 SI SI201230220T patent/SI2699575T1/sl unknown
- 2012-04-16 AP AP2013007182A patent/AP3491A/xx active
- 2012-04-16 WO PCT/EP2012/056914 patent/WO2012143329A1/en not_active Ceased
- 2012-04-16 PT PT127217792T patent/PT2699575E/pt unknown
- 2012-04-16 PL PL12721779T patent/PL2699575T3/pl unknown
- 2012-04-16 JP JP2014505584A patent/JP5989091B2/ja not_active Expired - Fee Related
- 2012-04-16 US US14/113,017 patent/US20140120087A1/en not_active Abandoned
- 2012-04-16 ES ES12721779.2T patent/ES2539265T3/es active Active
- 2012-04-16 SG SG2013073044A patent/SG194003A1/en unknown
- 2012-04-16 MX MX2013012289A patent/MX348783B/es active IP Right Grant
- 2012-04-16 MY MYPI2013701964A patent/MY164939A/en unknown
- 2012-04-16 PH PH1/2013/502169A patent/PH12013502169A1/en unknown
- 2012-04-16 CA CA2833657A patent/CA2833657A1/en not_active Abandoned
- 2012-04-16 PE PE2013002378A patent/PE20141351A1/es not_active Application Discontinuation
- 2012-04-16 CN CN201280030682.XA patent/CN103608350B/zh not_active Expired - Fee Related
- 2012-04-16 AU AU2012244859A patent/AU2012244859B2/en not_active Ceased
- 2012-04-16 EP EP12721779.2A patent/EP2699575B1/en active Active
- 2012-04-16 KR KR1020137030546A patent/KR20140025470A/ko not_active Ceased
- 2012-04-16 HU HUE12721779A patent/HUE025496T2/en unknown
- 2012-04-16 HR HRP20150517TT patent/HRP20150517T1/hr unknown
- 2012-04-18 SA SA112330466A patent/SA112330466B1/ar unknown
- 2012-04-18 JO JOP/2012/0093A patent/JO3040B1/ar active
- 2012-04-20 TW TW101114259A patent/TWI558703B/zh not_active IP Right Cessation
- 2012-04-20 UY UY0001034034A patent/UY34034A/es not_active Application Discontinuation
- 2012-04-20 AR ARP120101355A patent/AR086191A1/es unknown
-
2013
- 2013-10-03 IL IL228704A patent/IL228704A0/en unknown
- 2013-10-18 GT GT201300254A patent/GT201300254A/es unknown
- 2013-10-21 DO DO2013000244A patent/DOP2013000244A/es unknown
- 2013-10-21 CO CO13248763A patent/CO6801751A2/es active IP Right Grant
- 2013-10-21 CL CL2013003044A patent/CL2013003044A1/es unknown
- 2013-10-21 CR CR20130539A patent/CR20130539A/es unknown
- 2013-11-05 EC ECSP13013011 patent/ECSP13013011A/es unknown
- 2013-11-20 ZA ZA2013/08707A patent/ZA201308707B/en unknown
-
2015
- 2015-06-12 CY CY20151100512T patent/CY1116439T1/el unknown
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