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ITTO930167A1 - Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la memoria e l'apprendimento. - Google Patents

Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la memoria e l'apprendimento.

Info

Publication number
ITTO930167A1
ITTO930167A1 IT000167A ITTO930167A ITTO930167A1 IT TO930167 A1 ITTO930167 A1 IT TO930167A1 IT 000167 A IT000167 A IT 000167A IT TO930167 A ITTO930167 A IT TO930167A IT TO930167 A1 ITTO930167 A1 IT TO930167A1
Authority
IT
Italy
Prior art keywords
group
pct
learning
dicyclic
procedure
Prior art date
Application number
IT000167A
Other languages
English (en)
Inventor
Francesco Makovec
Walter Peris
Lucio Rovati
Luigi Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Publication of ITTO930167A0 publication Critical patent/ITTO930167A0/it
Priority to IT93TO000167A priority Critical patent/IT1264765B1/it
Priority to EP94909905A priority patent/EP0688312B1/en
Priority to ES94909905T priority patent/ES2128554T3/es
Priority to AU62573/94A priority patent/AU685438B2/en
Priority to US08/513,964 priority patent/US5723494A/en
Priority to PCT/EP1994/000604 priority patent/WO1994020454A1/en
Priority to AT94909905T priority patent/ATE173461T1/de
Priority to DE69414695T priority patent/DE69414695T2/de
Priority to JP51955394A priority patent/JP3957742B2/ja
Priority to CA002156432A priority patent/CA2156432C/en
Publication of ITTO930167A1 publication Critical patent/ITTO930167A1/it
Application granted granted Critical
Publication of IT1264765B1 publication Critical patent/IT1264765B1/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20Spiro-condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/18Systems containing only non-condensed rings with a ring being at least seven-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/26All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28Hydrogenated naphthalenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/36Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/56Ring systems containing bridged rings
    • C07C2603/58Ring systems containing bridged rings containing three rings
    • C07C2603/70Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74Adamantanes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IT93TO000167A 1993-03-10 1993-03-10 Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la IT1264765B1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT93TO000167A IT1264765B1 (it) 1993-03-10 1993-03-10 Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la
US08/513,964 US5723494A (en) 1993-03-10 1994-03-02 Derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning
ES94909905T ES2128554T3 (es) 1993-03-10 1994-03-02 Nuevos derivados del acido glutamico, procedimiento para su preparacion y su utilizacion como medicamentos para el aumento de la memoria y aprendizaje.
AU62573/94A AU685438B2 (en) 1993-03-10 1994-03-02 New derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning
EP94909905A EP0688312B1 (en) 1993-03-10 1994-03-02 New derivatives of glutamic acid, a method of preparing them, and their use as drugs for enhancing memory and learning
PCT/EP1994/000604 WO1994020454A1 (en) 1993-03-10 1994-03-02 New derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning
AT94909905T ATE173461T1 (de) 1993-03-10 1994-03-02 Glutaminsäure-derivate, ein verfahren zu ihrer herstellung und ihre verwendung zur steigerung des erinnerungsvermögens und der lernfähigkeit
DE69414695T DE69414695T2 (de) 1993-03-10 1994-03-02 Glutaminsäure-derivate, ein verfahren zu ihrer herstellung und ihre verwendung zur steigerung des erinnerungsvermögens und der lernfähigkeit
JP51955394A JP3957742B2 (ja) 1993-03-10 1994-03-02 グルタミン酸およびアスパラギン酸の新規誘導体、その製造方法およびその記憶力および学習力の増強用医薬品としての用途
CA002156432A CA2156432C (en) 1993-03-10 1994-03-02 New derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93TO000167A IT1264765B1 (it) 1993-03-10 1993-03-10 Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la

Publications (3)

Publication Number Publication Date
ITTO930167A0 ITTO930167A0 (it) 1993-03-10
ITTO930167A1 true ITTO930167A1 (it) 1994-09-10
IT1264765B1 IT1264765B1 (it) 1996-10-04

Family

ID=11411249

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93TO000167A IT1264765B1 (it) 1993-03-10 1993-03-10 Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la

Country Status (10)

Country Link
US (1) US5723494A (it)
EP (1) EP0688312B1 (it)
JP (1) JP3957742B2 (it)
AT (1) ATE173461T1 (it)
AU (1) AU685438B2 (it)
CA (1) CA2156432C (it)
DE (1) DE69414695T2 (it)
ES (1) ES2128554T3 (it)
IT (1) IT1264765B1 (it)
WO (1) WO1994020454A1 (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1276462B1 (it) * 1995-07-03 1997-10-31 Rotta Research Lab Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico
IT1286141B1 (it) * 1996-07-02 1998-07-07 Rotta Research Lab Derivati diammidici dell'acido antranilico ad attivita' antigastrinica procedimento per la loro preparazione e loro uso farmaceutico.
US6218383B1 (en) * 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
US20100222316A1 (en) * 2004-04-29 2010-09-02 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8415354B2 (en) 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
ITTO20040343A1 (it) * 2004-05-24 2004-08-24 Rotta Res Lab Spa Uso di neboglamine (cr2249) come neuropsicotico e neuroprotettivo
JP4564375B2 (ja) * 2004-08-18 2010-10-20 太陽化学株式会社 テアニンの製造方法
EP1853246A1 (en) * 2005-02-17 2007-11-14 Instituto del Metabolismo Celular, S.L. L-aspartic acid for the treatment of problems in connection with the fat or glucose metabolism
ITTO20050691A1 (it) 2005-10-04 2007-04-05 Rottapharm Spa Uso di neboglamine nella terapia delle tossicodipendenze
EP1903028A1 (en) * 2006-09-22 2008-03-26 Werner Tschollar Conjugates of glutamate and NMDA receptor channel blockers without excito-toxic effects
KR102239629B1 (ko) * 2019-05-24 2021-04-12 이지원 실크 펩타이드의 제조방법 및 이를 이용하여 제조된 기억력 및 인지능력 개선용 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1228271A (it) * 1968-02-09 1971-04-15
US4053609A (en) * 1975-09-12 1977-10-11 Tanabe Seiyaku Co., Ltd. Penicillins and processes for preparing the same
JPS56131554A (en) * 1980-03-17 1981-10-15 Kaken Pharmaceut Co Ltd Novel d-glutamic acid derivative, its preparation, and immunizing agent containing said derivative as effective component
EP0436612A4 (en) * 1988-09-30 1992-05-20 Australian Commercial Research & Development Limited Amino acid transport proteins, amino acid analogues, assay apparatus, uses thereof for treatment and diagnosis of cancer
WO1991012232A1 (en) * 1990-02-06 1991-08-22 Australian Commercial Research & Development Limited Compounds and methods for the treatment and diagnosis of cancer
JPH03294253A (ja) * 1990-04-12 1991-12-25 Shionogi & Co Ltd 消化管ホルモン拮抗物質
AU8844891A (en) * 1990-10-22 1992-05-20 Universidad De Granada Hydrolisis method and utilization of aminoacil-2-naphtylamide as diagnosis reagent
IT1241029B (it) * 1990-12-11 1993-12-27 Rotta Research Lab Derivati amidici biciclici e policiclici degli acidi glutammico, aspartico e 2-ammino adipico ad attivita' antigastrinica e procedimento per la loro preparazione

Also Published As

Publication number Publication date
ATE173461T1 (de) 1998-12-15
EP0688312B1 (en) 1998-11-18
CA2156432A1 (en) 1994-09-15
ES2128554T3 (es) 1999-05-16
JPH08507502A (ja) 1996-08-13
US5723494A (en) 1998-03-03
CA2156432C (en) 2006-11-14
DE69414695D1 (de) 1998-12-24
IT1264765B1 (it) 1996-10-04
DE69414695T2 (de) 1999-06-10
EP0688312A1 (en) 1995-12-27
WO1994020454A1 (en) 1994-09-15
ITTO930167A0 (it) 1993-03-10
AU6257394A (en) 1994-09-26
AU685438B2 (en) 1998-01-22
JP3957742B2 (ja) 2007-08-15

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