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IT201900003839A1 - Sintesi di apalutamide amorfa stabile - Google Patents

Sintesi di apalutamide amorfa stabile

Info

Publication number
IT201900003839A1
IT201900003839A1 IT102019000003839A IT201900003839A IT201900003839A1 IT 201900003839 A1 IT201900003839 A1 IT 201900003839A1 IT 102019000003839 A IT102019000003839 A IT 102019000003839A IT 201900003839 A IT201900003839 A IT 201900003839A IT 201900003839 A1 IT201900003839 A1 IT 201900003839A1
Authority
IT
Italy
Prior art keywords
apalutamide
synthesis
stable amorphous
amorphous
stable
Prior art date
Application number
IT102019000003839A
Other languages
English (en)
Original Assignee
Olon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olon Spa filed Critical Olon Spa
Priority to IT102019000003839A priority Critical patent/IT201900003839A1/it
Priority to PCT/IB2020/052011 priority patent/WO2020188399A1/en
Priority to EP20714281.1A priority patent/EP3938361A1/en
Priority to US17/438,948 priority patent/US20220153718A1/en
Publication of IT201900003839A1 publication Critical patent/IT201900003839A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT102019000003839A 2019-03-15 2019-03-15 Sintesi di apalutamide amorfa stabile IT201900003839A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT102019000003839A IT201900003839A1 (it) 2019-03-15 2019-03-15 Sintesi di apalutamide amorfa stabile
PCT/IB2020/052011 WO2020188399A1 (en) 2019-03-15 2020-03-09 Synthesis of stable amorphous apalutamide
EP20714281.1A EP3938361A1 (en) 2019-03-15 2020-03-09 Synthesis of stable amorphous apalutamide
US17/438,948 US20220153718A1 (en) 2019-03-15 2020-03-09 Synthesis of stable amorphous apalutamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000003839A IT201900003839A1 (it) 2019-03-15 2019-03-15 Sintesi di apalutamide amorfa stabile

Publications (1)

Publication Number Publication Date
IT201900003839A1 true IT201900003839A1 (it) 2020-09-15

Family

ID=67002159

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102019000003839A IT201900003839A1 (it) 2019-03-15 2019-03-15 Sintesi di apalutamide amorfa stabile

Country Status (4)

Country Link
US (1) US20220153718A1 (it)
EP (1) EP3938361A1 (it)
IT (1) IT201900003839A1 (it)
WO (1) WO2020188399A1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116332907A (zh) * 2023-03-16 2023-06-27 奥锐特药业股份有限公司 一种无定形阿帕他胺的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8445507B2 (en) 2006-03-27 2013-05-21 The Regents Of The University Of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
WO2013184681A1 (en) 2012-06-07 2013-12-12 Aragon Pharmaceuticals, Inc. Crystalline forms of an androgen receptor modulator
WO2016124149A1 (zh) 2015-02-06 2016-08-11 苏州晶云药物科技有限公司 一种治疗前列腺癌的抗雄激素类药物的新晶型及其制备方法
WO2018112001A1 (en) 2016-12-13 2018-06-21 Watson Laboratories Inc. Solid state forms of apalutamide
WO2019016747A1 (en) 2017-07-20 2019-01-24 Dr. Reddy's Laboratories Limited AMORPHOUS SOLID DISPERSIONS OF APALUTAMIDE AND PROCESS FOR THEIR PREPARATION

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8445507B2 (en) 2006-03-27 2013-05-21 The Regents Of The University Of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
WO2013184681A1 (en) 2012-06-07 2013-12-12 Aragon Pharmaceuticals, Inc. Crystalline forms of an androgen receptor modulator
WO2016124149A1 (zh) 2015-02-06 2016-08-11 苏州晶云药物科技有限公司 一种治疗前列腺癌的抗雄激素类药物的新晶型及其制备方法
WO2018112001A1 (en) 2016-12-13 2018-06-21 Watson Laboratories Inc. Solid state forms of apalutamide
WO2019016747A1 (en) 2017-07-20 2019-01-24 Dr. Reddy's Laboratories Limited AMORPHOUS SOLID DISPERSIONS OF APALUTAMIDE AND PROCESS FOR THEIR PREPARATION

Also Published As

Publication number Publication date
US20220153718A1 (en) 2022-05-19
WO2020188399A1 (en) 2020-09-24
EP3938361A1 (en) 2022-01-19

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