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IT1398729B1 - Processo per la preparazione di testosterone - Google Patents

Processo per la preparazione di testosterone

Info

Publication number
IT1398729B1
IT1398729B1 ITMI2009A001168A ITMI20091168A IT1398729B1 IT 1398729 B1 IT1398729 B1 IT 1398729B1 IT MI2009A001168 A ITMI2009A001168 A IT MI2009A001168A IT MI20091168 A ITMI20091168 A IT MI20091168A IT 1398729 B1 IT1398729 B1 IT 1398729B1
Authority
IT
Italy
Prior art keywords
testosterone
preparation
Prior art date
Application number
ITMI2009A001168A
Other languages
English (en)
Inventor
Stefano Fogal
Riccardo Motterle
Giancarlo Arvotti
Elisabetta Motterle
Andrea Castellin
Original Assignee
F S I Fabbrica Italiana Sint
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F S I Fabbrica Italiana Sint filed Critical F S I Fabbrica Italiana Sint
Priority to ITMI2009A001168A priority Critical patent/IT1398729B1/it
Priority to CA2767052A priority patent/CA2767052C/en
Priority to EP10725454.2A priority patent/EP2449128B1/en
Priority to AU2010268260A priority patent/AU2010268260B2/en
Priority to US13/119,915 priority patent/US8592178B2/en
Priority to PCT/EP2010/058411 priority patent/WO2011000693A1/en
Publication of ITMI20091168A1 publication Critical patent/ITMI20091168A1/it
Application granted granted Critical
Publication of IT1398729B1 publication Critical patent/IT1398729B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01062—17Beta-estradiol 17-dehydrogenase (1.1.1.62)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
ITMI2009A001168A 2009-07-01 2009-07-01 Processo per la preparazione di testosterone IT1398729B1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ITMI2009A001168A IT1398729B1 (it) 2009-07-01 2009-07-01 Processo per la preparazione di testosterone
CA2767052A CA2767052C (en) 2009-07-01 2010-06-15 Process for the preparation of testosterone
EP10725454.2A EP2449128B1 (en) 2009-07-01 2010-06-15 Enzymatic process for the preparation of testosterone using a "tag"
AU2010268260A AU2010268260B2 (en) 2009-07-01 2010-06-15 Process for the preparation of testosterone
US13/119,915 US8592178B2 (en) 2009-07-01 2010-06-15 Process for the preparation of testosterone
PCT/EP2010/058411 WO2011000693A1 (en) 2009-07-01 2010-06-15 Process for the preparation of testosterone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2009A001168A IT1398729B1 (it) 2009-07-01 2009-07-01 Processo per la preparazione di testosterone

Publications (2)

Publication Number Publication Date
ITMI20091168A1 ITMI20091168A1 (it) 2011-01-02
IT1398729B1 true IT1398729B1 (it) 2013-03-18

Family

ID=41667441

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2009A001168A IT1398729B1 (it) 2009-07-01 2009-07-01 Processo per la preparazione di testosterone

Country Status (6)

Country Link
US (1) US8592178B2 (it)
EP (1) EP2449128B1 (it)
AU (1) AU2010268260B2 (it)
CA (1) CA2767052C (it)
IT (1) IT1398729B1 (it)
WO (1) WO2011000693A1 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20111338A1 (it) * 2011-07-19 2013-01-20 Italiana Sint Spa Procedimento di sintesi bioenzimatica ad alte concentrazioni di testosterone
WO2013117251A1 (de) 2012-02-07 2013-08-15 Annikki Gmbh Verfahren zur enzymatischen regenerierung von redoxkofaktoren
TW201343623A (zh) 2012-02-07 2013-11-01 Annikki Gmbh 使氧化還原輔因子經酶催化再生之方法
ITVI20130039A1 (it) 2013-02-20 2014-08-21 F I S Fabbrica Italiana Sint I S P A Processo per la preparazione di intermedi chiave per la sintesi di statine
EP3064589A1 (en) * 2015-07-29 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatic process for the preparation of testosterone and esters thereof
WO2017093980A1 (en) 2015-12-05 2017-06-08 Lupin Limited Process for preparation of testosterone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643758A (en) * 1987-03-10 1997-07-01 New England Biolabs, Inc. Production and purification of a protein fused to a binding protein
AU3269399A (en) * 1999-03-22 2000-10-09 Universitat Zurich Transforming growth factor (tfg) beta superfamily antagonists
AT503486B1 (de) * 2006-04-11 2008-05-15 Iep Gmbh Verfahren zur enantioselektiven reduktion von steroiden

Also Published As

Publication number Publication date
ITMI20091168A1 (it) 2011-01-02
AU2010268260A1 (en) 2012-02-02
EP2449128A1 (en) 2012-05-09
AU2010268260B2 (en) 2014-07-31
CA2767052C (en) 2017-12-19
US20110207172A1 (en) 2011-08-25
US8592178B2 (en) 2013-11-26
WO2011000693A1 (en) 2011-01-06
CA2767052A1 (en) 2011-01-06
EP2449128B1 (en) 2017-05-10

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