IT1233251B - Digoxin solns in capsule form - Google Patents
Digoxin solns in capsule formInfo
- Publication number
- IT1233251B IT1233251B IT8349395A IT4939583A IT1233251B IT 1233251 B IT1233251 B IT 1233251B IT 8349395 A IT8349395 A IT 8349395A IT 4939583 A IT4939583 A IT 4939583A IT 1233251 B IT1233251 B IT 1233251B
- Authority
- IT
- Italy
- Prior art keywords
- digoxin
- solns
- contg
- soluble
- capsule form
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title abstract 3
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 title abstract 2
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 title abstract 2
- 229960005156 digoxin Drugs 0.000 title abstract 2
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 title abstract 2
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000000975 dye Substances 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 239000003605 opacifier Substances 0.000 abstract 1
- 239000004014 plasticizer Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compsns. contg. digoxin (I) soln. in a soluble capsule coating are new. The capsule is pref. soluble in the upper part of the mammalian gastro-intestinal tract, and is suitably of soft gelatin contg. \-1 of plasticisers, preservatives dyes and opacifiers, Dosage is esp. 0.05-0.4 mg (I) per unit. (I) is used in treatment of cardiac insufficiency. (I) is taken up more rapidly and uniformly than when administered by tablets, so the risk of overdosing is reduced. The dose required is only 80% of that needed in tablet form.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44496174A | 1974-02-22 | 1974-02-22 | |
| US45300074A | 1974-03-19 | 1974-03-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8349395A0 IT8349395A0 (en) | 1983-11-28 |
| IT1233251B true IT1233251B (en) | 1992-03-24 |
Family
ID=27034126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT8349395A IT1233251B (en) | 1974-02-22 | 1983-11-28 | Digoxin solns in capsule form |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS50126822A (en) |
| AU (2) | AU501549B2 (en) |
| CA (1) | CA1096307A (en) |
| DE (1) | DE2507635A1 (en) |
| ES (1) | ES434971A1 (en) |
| FI (1) | FI750489A7 (en) |
| FR (1) | FR2261752B1 (en) |
| GB (1) | GB1506016A (en) |
| IE (1) | IE41620B1 (en) |
| IL (1) | IL46682A (en) |
| IT (1) | IT1233251B (en) |
| LU (1) | LU71894A1 (en) |
| NL (1) | NL7502121A (en) |
| SE (1) | SE426549B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1508770A (en) * | 1974-04-01 | 1978-04-26 | Scherer Ltd R | Pharmaceutical compositions |
| US4002718A (en) * | 1974-10-16 | 1977-01-11 | Arnar-Stone Laboratories, Inc. | Gelatin-encapsulated digoxin solutions and method of preparing the same |
| DE2805165A1 (en) * | 1977-02-09 | 1978-08-10 | Christiaens Sa A | MEDICINAL PRODUCT CONTAINING GITOXIN AND THE METHOD OF MANUFACTURING IT |
| IT1158722B (en) * | 1977-07-08 | 1987-02-25 | Simes | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SLEEP TURBES |
| JPS5625428U (en) * | 1979-08-03 | 1981-03-09 | ||
| US4366145A (en) * | 1981-06-24 | 1982-12-28 | Sandoz, Inc. | Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation |
| US4994260A (en) * | 1982-05-28 | 1991-02-19 | Astra Lakemedel Aktiebolag | Pharmaceutical mixture |
| SE8203953D0 (en) * | 1982-06-24 | 1982-06-24 | Astra Laekemedel Ab | PHARMACEUTICAL MIXTURE |
| DE3445237C1 (en) * | 1984-12-12 | 1986-06-05 | R.P. Scherer GmbH, 6930 Eberbach | Soft gelatin capsules and process for their manufacture |
| DE3529694A1 (en) * | 1985-08-20 | 1987-02-26 | Scherer Gmbh R P | GELATINE CAPSULES AND METHOD FOR THEIR PRODUCTION |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1481411A (en) * | 1973-07-20 | 1977-07-27 | Scherer Ltd R | Pharmaceutical compositions |
-
1975
- 1975-02-21 NL NL7502121A patent/NL7502121A/en active Search and Examination
- 1975-02-21 SE SE7501967A patent/SE426549B/en not_active IP Right Cessation
- 1975-02-21 ES ES434971A patent/ES434971A1/en not_active Expired
- 1975-02-21 AU AU78440/75A patent/AU501549B2/en not_active Expired
- 1975-02-21 LU LU71894A patent/LU71894A1/xx unknown
- 1975-02-21 FI FI750489A patent/FI750489A7/fi not_active Application Discontinuation
- 1975-02-21 JP JP50021803A patent/JPS50126822A/ja active Pending
- 1975-02-21 IE IE371/75A patent/IE41620B1/en unknown
- 1975-02-21 DE DE19752507635 patent/DE2507635A1/en active Granted
- 1975-02-21 IL IL46682A patent/IL46682A/en unknown
- 1975-02-21 FR FR7505457A patent/FR2261752B1/fr not_active Expired
- 1975-02-21 CA CA220,535A patent/CA1096307A/en not_active Expired
- 1975-02-21 GB GB7327/75A patent/GB1506016A/en not_active Expired
-
1979
- 1979-05-28 AU AU47500/79A patent/AU520082B2/en not_active Ceased
-
1983
- 1983-11-28 IT IT8349395A patent/IT1233251B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| LU71894A1 (en) | 1975-12-09 |
| FR2261752B1 (en) | 1978-07-21 |
| DE2507635A1 (en) | 1975-08-28 |
| IE41620L (en) | 1975-08-22 |
| FR2261752A1 (en) | 1975-09-19 |
| AU7844075A (en) | 1976-08-26 |
| AU501549B2 (en) | 1979-06-21 |
| SE426549B (en) | 1983-01-31 |
| CA1096307A (en) | 1981-02-24 |
| NL7502121A (en) | 1975-08-26 |
| IE41620B1 (en) | 1980-02-13 |
| DE2507635C2 (en) | 1991-07-25 |
| FI750489A7 (en) | 1975-08-23 |
| SE7501967L (en) | 1975-08-25 |
| IL46682A (en) | 1979-07-25 |
| ES434971A1 (en) | 1977-05-16 |
| IL46682A0 (en) | 1975-04-25 |
| IT8349395A0 (en) | 1983-11-28 |
| JPS50126822A (en) | 1975-10-06 |
| AU520082B2 (en) | 1982-01-14 |
| GB1506016A (en) | 1978-04-05 |
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