IT1217685B - Inibitori della hmg coa riduttasi contenenti fosforo e metodo per il loro impiego - Google Patents

Inibitori della hmg coa riduttasi contenenti fosforo e metodo per il loro impiego

Info

Publication number: IT1217685B
Authority: IT; Italy
Prior art keywords: containing phosphorus; hmg coa; coa inhibitors; inhibitors reduced; reduced containing
Prior art date: 1987-05-22

Application number

IT20682/88A

Other languages

English (en)

Other versions

IT8820682A0 (it

Inventor

Donald Steven Karanewsky

Scott Adams Biller

Eric Michael Gordon

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-22

Filing date

1988-05-20

Publication date

1990-03-30

1988-05-20 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1988-05-20 Publication of IT8820682A0 publication Critical patent/IT8820682A0/it

1990-03-30 Application granted granted Critical

1990-03-30 Publication of IT1217685B publication Critical patent/IT1217685B/it

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/36—Amides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4407—Amides of acyclic saturated acids which can have further substituents on alkyl

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IT20682/88A 1987-05-22 1988-05-20 Inibitori della hmg coa riduttasi contenenti fosforo e metodo per il loro impiego IT1217685B (it)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5328187A	1987-05-22	1987-05-22
US10968087A	1987-10-19	1987-10-19

Publications (2)

Publication Number	Publication Date
IT8820682A0 IT8820682A0 (it)	1988-05-20
IT1217685B true IT1217685B (it)	1990-03-30

Family

ID=26731667

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT20682/88A IT1217685B (it)	1987-05-22	1988-05-20	Inibitori della hmg coa riduttasi contenenti fosforo e metodo per il loro impiego

Country Status (24)

Country	Link
JP (1)	JP2680347B2 (it)
KR (1)	KR880013958A (it)
CN (1)	CN88103091A (it)
AU (1)	AU610591B2 (it)
BE (1)	BE1004193A3 (it)
CH (1)	CH676984A5 (it)
DE (1)	DE3817375C2 (it)
DK (1)	DK277488A (it)
ES (1)	ES2009918A6 (it)
FI (1)	FI89493C (it)
FR (1)	FR2615508B1 (it)
GB (1)	GB2205837B (it)
GR (1)	GR1000959B (it)
HU (1)	HU205125B (it)
IE (2)	IE930324L (it)
IL (1)	IL86464A (it)
IT (1)	IT1217685B (it)
NL (1)	NL8801330A (it)
NO (1)	NO882218L (it)
NZ (1)	NZ224733A (it)
PH (1)	PH25350A (it)
PL (1)	PL154877B1 (it)
PT (1)	PT87539B (it)
SE (1)	SE503210C2 (it)

Families Citing this family (71)

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DK277388A (da) *	1987-05-22	1988-11-23	Squibb & Sons Inc	Phosphorholdige hmg-coa-reduktase-inhibitorer, mellemprodukter og fremgangsmaade
CA2007643A1 (en) *	1989-02-01	1990-08-01	Donald S. Karanewsky	Combination of an hmg coa reductase inhibitor and a squalene synthetase inhibitor and method for lowering serum cholesterol using such combination
CA2042526A1 (en) *	1990-06-11	1991-12-12	Adeoye Y. Olukotun	Method for preventing a second heart attack employing an hmg coa reductase inhibitor
US5202327A (en) *	1991-07-10	1993-04-13	E. R. Squibb & Sons, Inc.	Phosphorus-containing hmg-coa reductase inhibitors
GB9126144D0 (en) *	1991-12-10	1992-02-12	British Bio Technology	Compounds
US20010006644A1 (en)	1997-07-31	2001-07-05	David J. Bova	Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
CA2344309A1 (en)	1998-09-17	2000-03-23	Scott A. Biller	Method for treating diabetes employing an ap2 inhibitor and combination
DE60209343T2 (de)	2001-04-11	2006-10-26	Bristol-Myers Squibb Co.	Aminosäurekomplexe von c-arylglycosiden zur behandlung von diabetes und verfahren
US7238671B2 (en)	2001-10-18	2007-07-03	Bristol-Myers Squibb Company	Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
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US6806381B2 (en)	2001-11-02	2004-10-19	Bristol-Myers Squibb Company	Process for the preparation of aniline-derived thyroid receptor ligands
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US7098235B2 (en)	2002-11-14	2006-08-29	Bristol-Myers Squibb Co.	Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
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US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US6995183B2 (en)	2003-08-01	2006-02-07	Bristol Myers Squibb Company	Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
US8158362B2 (en)	2005-03-30	2012-04-17	Decode Genetics Ehf.	Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
CA2910191C (en)	2004-03-05	2022-03-08	The Trustees Of The Univeristy Of Pennsylvania	The use of mtp inhibitors for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects
US7534763B2 (en)	2004-07-02	2009-05-19	Bristol-Myers Squibb Company	Sustained release GLP-1 receptor modulators
TW200611704A (en)	2004-07-02	2006-04-16	Bristol Myers Squibb Co	Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
US7145040B2 (en)	2004-07-02	2006-12-05	Bristol-Myers Squibb Co.	Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
AR051446A1 (es)	2004-09-23	2007-01-17	Bristol Myers Squibb Co	Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2)
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US7220859B2 (en)	2005-01-12	2007-05-22	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid receptor modulators
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ZA828650B (en) *	1981-12-01	1983-09-28	Hunt Chem Corp Philip A	Herbicidal compositions and method using phosphonalkanoic acids, esters and salts thereof
FR2596393B1 (fr) *	1986-04-01	1988-06-03	Sanofi Sa	Derives de l'acide hydroxy-3 dihydroxyoxophosphorio-4 butanoique, leur procede de preparation, leur application comme medicament et les compositions les renfermant
DK277388A (da) *	1987-05-22	1988-11-23	Squibb & Sons Inc	Phosphorholdige hmg-coa-reduktase-inhibitorer, mellemprodukter og fremgangsmaade

1988
- 1988-05-20 ES ES8801610A patent/ES2009918A6/es not_active Expired
- 1988-05-20 GR GR880100331A patent/GR1000959B/el unknown
- 1988-05-20 PH PH36956A patent/PH25350A/en unknown
- 1988-05-20 GB GB8811929A patent/GB2205837B/en not_active Expired - Fee Related
- 1988-05-20 DE DE3817375A patent/DE3817375C2/de not_active Expired - Fee Related
- 1988-05-20 SE SE8801903A patent/SE503210C2/sv not_active IP Right Cessation
- 1988-05-20 HU HU882614A patent/HU205125B/hu not_active IP Right Cessation
- 1988-05-20 IE IE930324A patent/IE930324L/xx unknown
- 1988-05-20 AU AU16508/88A patent/AU610591B2/en not_active Ceased
- 1988-05-20 PT PT87539A patent/PT87539B/pt not_active IP Right Cessation
- 1988-05-20 DK DK277488A patent/DK277488A/da not_active Application Discontinuation
- 1988-05-20 FI FI882384A patent/FI89493C/fi not_active IP Right Cessation
- 1988-05-20 IL IL86464A patent/IL86464A/xx not_active IP Right Cessation
- 1988-05-20 IT IT20682/88A patent/IT1217685B/it active
- 1988-05-20 NO NO882218A patent/NO882218L/no unknown
- 1988-05-20 IE IE154388A patent/IE63760B1/en not_active IP Right Cessation
- 1988-05-20 NZ NZ224733A patent/NZ224733A/en unknown
- 1988-05-21 JP JP63124809A patent/JP2680347B2/ja not_active Expired - Lifetime
- 1988-05-21 CN CN198888103091A patent/CN88103091A/zh active Pending
- 1988-05-21 PL PL1988272597A patent/PL154877B1/pl unknown
- 1988-05-21 KR KR1019880006020A patent/KR880013958A/ko not_active Ceased
- 1988-05-24 CH CH1967/88A patent/CH676984A5/fr not_active IP Right Cessation
- 1988-05-24 NL NL8801330A patent/NL8801330A/nl not_active Application Discontinuation
- 1988-05-24 BE BE8800566A patent/BE1004193A3/fr not_active IP Right Cessation
- 1988-05-24 FR FR8806885A patent/FR2615508B1/fr not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CH676984A5 (it)	1991-03-28
FI882384A0 (fi)	1988-05-20
NO882218L (no)	1988-11-23
GB2205837A (en)	1988-12-21
AU1650888A (en)	1988-11-24
GB2205837B (en)	1991-11-20
HU205125B (en)	1992-03-30
NO882218D0 (no)	1988-05-20
NZ224733A (en)	1990-12-21
BE1004193A3 (fr)	1992-10-13
ES2009918A6 (es)	1989-10-16
PL154877B1 (en)	1991-09-30
SE8801903L (sv)	1988-11-23
KR880013958A (ko)	1988-12-22
CN88103091A (zh)	1988-12-21
PT87539B (pt)	1992-09-30
FI89493B (fi)	1993-06-30
PH25350A (en)	1991-05-13
JP2680347B2 (ja)	1997-11-19
GR880100331A (en)	1989-02-23
JPS6456689A (en)	1989-03-03
GR1000959B (el)	1993-03-16
FI89493C (fi)	1993-10-11
IL86464A0 (en)	1988-11-15
HUT49358A (en)	1989-09-28
AU610591B2 (en)	1991-05-23
NL8801330A (nl)	1988-12-16
FR2615508A1 (fr)	1988-11-25
DK277488D0 (da)	1988-05-20
DE3817375A1 (de)	1988-12-08
SE8801903D0 (sv)	1988-05-20
IL86464A (en)	1993-06-10
IE881543L (en)	1988-11-22
GB8811929D0 (en)	1988-06-22
IE63760B1 (en)	1995-06-14
IE930324L (en)	1988-11-22
SE503210C2 (sv)	1996-04-22
PT87539A (pt)	1989-05-31
IT8820682A0 (it)	1988-05-20
FR2615508B1 (fr)	1994-11-25
PL272597A1 (en)	1989-03-06
FI882384A7 (fi)	1988-11-23
DK277488A (da)	1988-11-23
DE3817375C2 (de)	1997-04-30

Publication	Publication Date	Title
IT1217685B (it)	1990-03-30	Inibitori della hmg coa riduttasi contenenti fosforo e metodo per il loro impiego
FI882007A0 (fi)	1988-04-28	Menetelmä steroidi-5- -reduktaasin inhibiittorien valmistamiseksi
NZ215024A (en)	1989-08-29	Peptidase inhibitors
IL78862A (en)	1990-03-19	Method of determining stenosis
FI883477L (fi)	1989-01-24	Menetelmä kudosfaktorin inhibiittorin eristämiseksi
KR950700279A (ko)	1995-01-16	세포 유착저해제인 3-알킬옥시-, 아릴옥시-, 또는 아릴알킬옥시벤조[b]티오펜-2-카르복스아미드류(3-Alkyloxy-, Aryloxy-, or Arylalkyloxybenzo[b]thiophene-2-Carboxamides as Inhibitors of Cell Adhesion)
HU893412D0 (en)	1991-05-28	Inhibitors of interleucin-1
IT1217684B (it)	1990-03-30	Inibitori della hmg coa riduttasi contenenti fosforo,nuovi intermedi e procedimento
GB8707872D0 (en)	1987-05-07	Corrosion inhibitors
FI890363A7 (fi)	1989-01-25	Laite ja menetelmä höyry-nestekontaktia varten
GB2202534B (en)	1990-11-21	Phospholipase a2 inhibitors
DK349586D0 (da)	1986-07-23	Enzyminhibitor
DK0422975T3 (da)	1994-08-22	Alfa-Glucosidase-inhibitorer
FI885728A7 (fi)	1989-06-12	Korroosionestoaine
FI885746L (fi)	1989-06-13	Menetelmä tankomaisten työkappaleiden tukemiseksi
FI883671A7 (fi)	1989-02-07	Menetelmä analyytin visuaaliseksi määrittämiseksi
NO171134C (no)	1993-01-27	Fremgangsmaate ved seismiske undersoekelser
EP0291686A3 (en)	1990-04-04	Inhibitors of angiogenin
GB2173183B (en)	1988-12-07	Scale inhibitors
IT1204875B (it)	1989-03-10	Metodo per la determinazione della densita' dei substrati
KR870004028A (ko)	1987-05-07	디하이드로리세르그산 에스테르 및 그의 제조방법
FI893977L (fi)	1990-03-15	Menetelmä jaloteräksen sinkitsemiseksi
EP0411395A3 (en)	1991-11-13	Use of ace inhibitors for atherosclerosis-prophylaxis
GB2175502B (en)	1989-07-05	Method of inhibiting the development of protozoa
FI901548A7 (fi)	1990-09-30	Uudet a-glukosidaasi-inhibiittorit

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970530