IT1203791B - DERIVATIVES OF MORFINANO AND MORFINA, THEIR PREPARATION, THEIR USE AS MEDICATIONS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

DERIVATIVES OF MORFINANO AND MORFINA, THEIR PREPARATION, THEIR USE AS MEDICATIONS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number: IT1203791B
Authority: IT; Italy
Prior art keywords: morfinano; morfina; medications; derivatives; preparation
Prior art date: 1985-05-23

Application number

IT48050/86A

Other languages

Italian (it)

Other versions

IT8648050A0 (en

Inventor

Laszlo Revesz

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-05-23

Filing date

1986-05-23

Publication date

1989-02-23

1986-05-23 Application filed by Sandoz Ag filed Critical Sandoz Ag

1986-05-23 Publication of IT8648050A0 publication Critical patent/IT8648050A0/en

1989-02-23 Application granted granted Critical

1989-02-23 Publication of IT1203791B publication Critical patent/IT1203791B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

IT48050/86A 1985-05-23 1986-05-23 DERIVATIVES OF MORFINANO AND MORFINA, THEIR PREPARATION, THEIR USE AS MEDICATIONS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IT1203791B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3518525		1985-05-23

Publications (2)

Publication Number	Publication Date
IT8648050A0 IT8648050A0 (en)	1986-05-23
IT1203791B true IT1203791B (en)	1989-02-23

Family

ID=6271435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT48050/86A IT1203791B (en)	1985-05-23	1986-05-23	DERIVATIVES OF MORFINANO AND MORFINA, THEIR PREPARATION, THEIR USE AS MEDICATIONS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (18)

Country	Link
JP (1)	JPS61271275A (en)
AU (1)	AU594954B2 (en)
BE (1)	BE904796A (en)
DK (1)	DK240386A (en)
ES (1)	ES8802318A1 (en)
FI (1)	FI862124L (en)
FR (1)	FR2582309B1 (en)
GB (1)	GB2175898B (en)
GR (1)	GR861318B (en)
HU (1)	HU196376B (en)
IL (1)	IL78872A0 (en)
IT (1)	IT1203791B (en)
LU (1)	LU86435A1 (en)
NL (1)	NL8601188A (en)
NZ (1)	NZ216250A (en)
PH (1)	PH23341A (en)
SE (1)	SE8602308L (en)
ZA (1)	ZA863873B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4857533A (en) *	1988-12-15	1989-08-15	Baker Cummins Pharmaceuticals, Inc.	Method of treatment for autoimmune diseases
US4863928A (en) *	1989-01-04	1989-09-05	Baker Cummins Pharmaceuticals, Inc.	Method of treatment for arthritic and inflammatory diseases
US4923875A (en) *	1989-07-10	1990-05-08	Baker Cummins Pharmaceuticals, Inc.	Method for treatment of mast cell-mediated dermatologic disorders
JP2906654B2 (en) *	1989-11-28	1999-06-21	東レ株式会社	Immunosuppressant and method for producing the same
US5057322A (en) *	1990-08-10	1991-10-15	Baker Cummins Dermatologicals, Inc.	Method of treating mast cell disease
DK0577847T3 (en) *	1992-01-23	1999-06-23	Toray Industries	Morphine derivative and its medical use
EP0661283B1 (en) *	1993-07-19	1998-10-21	Toray Industries, Inc.	Brain cell protective
CA2143864C (en) *	1993-07-23	2006-01-24	Hiroshi Nagase	Morphinan derivatives and pharmaceutical use thereof
WO1997025331A1 (en) *	1996-01-10	1997-07-17	Smithkline Beecham S.P.A.	Heterocycle-condensed morphinoid derivatives (ii)
DE69732868T2 (en) *	1996-11-25	2006-04-13	Toray Industries, Inc.	Remedy for itching
AU6117298A (en) *	1997-07-25	1999-02-16	Toray Industries, Inc.	Hyponatremia remedies
US7501433B2 (en)	2002-05-17	2009-03-10	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
MXPA04011327A (en)	2002-05-17	2005-08-15	Jenken Biosciences Inc	Opioid and opioid-like compounds and uses thereof.
US7923454B2 (en)	2002-05-17	2011-04-12	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
JP4957489B2 (en) *	2002-10-09	2012-06-20	東レ株式会社	Pharmaceutical containing morphinan derivative having nitrogen-containing cyclic substituent or pharmacologically acceptable acid addition salt thereof
US8017622B2 (en)	2003-05-16	2011-09-13	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
WO2009103004A1 (en) *	2008-02-14	2009-08-20	Alkermes, Inc.	Selective opioid compounds
US8980906B2 (en) *	2012-12-14	2015-03-17	Purdue Pharma L.P.	Pyridonemorphinan analogs and biological activity on opioid receptors
EP2931726B1 (en) *	2012-12-14	2017-01-25	Purdue Pharma LP	Spirocyclic morphinans and their use
AR096851A1 (en) *	2013-07-11	2016-02-03	H Lundbeck As	SALTS THAT DO NOT FORM HYDRATS OR SOLVATOS DE NALMEFENO
MA40171A (en) *	2014-06-13	2017-04-19	Purdue Pharma Lp	Azamophinan derivatives and use thereof

1986
- 1986-05-09 HU HU861934A patent/HU196376B/en not_active IP Right Cessation
- 1986-05-12 NL NL8601188A patent/NL8601188A/en not_active Application Discontinuation
- 1986-05-19 PH PH33785A patent/PH23341A/en unknown
- 1986-05-19 GB GB8612159A patent/GB2175898B/en not_active Expired
- 1986-05-21 NZ NZ216250A patent/NZ216250A/en unknown
- 1986-05-21 AU AU57637/86A patent/AU594954B2/en not_active Expired - Fee Related
- 1986-05-21 GR GR861318A patent/GR861318B/en unknown
- 1986-05-21 IL IL78872A patent/IL78872A0/en unknown
- 1986-05-21 BE BE1/011493A patent/BE904796A/en not_active IP Right Cessation
- 1986-05-21 FI FI862124A patent/FI862124L/en not_active Application Discontinuation
- 1986-05-21 ES ES555200A patent/ES8802318A1/en not_active Expired
- 1986-05-21 SE SE8602308A patent/SE8602308L/en not_active Application Discontinuation
- 1986-05-22 JP JP61118984A patent/JPS61271275A/en active Pending
- 1986-05-22 DK DK240386A patent/DK240386A/en not_active Application Discontinuation
- 1986-05-22 LU LU86435A patent/LU86435A1/en unknown
- 1986-05-23 FR FR8607367A patent/FR2582309B1/en not_active Expired
- 1986-05-23 ZA ZA863873A patent/ZA863873B/en unknown
- 1986-05-23 IT IT48050/86A patent/IT1203791B/en active

Also Published As

Publication number	Publication date
ES8802318A1 (en)	1988-05-01
FI862124A7 (en)	1986-11-24
JPS61271275A (en)	1986-12-01
SE8602308L (en)	1986-11-24
AU5763786A (en)	1986-11-27
IL78872A0 (en)	1986-09-30
FR2582309A1 (en)	1986-11-28
FI862124L (en)	1986-11-24
GB2175898A (en)	1986-12-10
IT8648050A0 (en)	1986-05-23
FI862124A0 (en)	1986-05-21
GB8612159D0 (en)	1986-06-25
HU196376B (en)	1988-11-28
FR2582309B1 (en)	1989-08-18
PH23341A (en)	1989-07-14
BE904796A (en)	1986-11-21
GR861318B (en)	1986-09-19
LU86435A1 (en)	1986-12-05
DK240386D0 (en)	1986-05-22
SE8602308D0 (en)	1986-05-21
DK240386A (en)	1986-11-24
ES555200A0 (en)	1988-05-01
GB2175898B (en)	1989-07-05
HUT41737A (en)	1987-05-28
NZ216250A (en)	1990-04-26
AU594954B2 (en)	1990-03-22
NL8601188A (en)	1986-12-16
ZA863873B (en)	1988-01-27

Publication	Publication Date	Title
IT8648157A0 (en)	1986-06-20	THIAZOLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IT1173724B (en)	1987-06-24	DERIVATIVES OF PIPERIDINE, THEIR PREPARATION AND THEIR USE AS MEDICATIONS
IT1203791B (en)	1989-02-23	DERIVATIVES OF MORFINANO AND MORFINA, THEIR PREPARATION, THEIR USE AS MEDICATIONS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IT8847556A0 (en)	1988-01-21	PEPTIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES
IT1200092B (en)	1989-01-05	AMINOPROPOSED DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICATIONS
IT8648701A0 (en)	1986-12-04	CALCITONIN DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES
IT1203743B (en)	1989-02-23	PEPTIDES AND PEPTIDAL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICATIONS
IT1219542B (en)	1990-05-18	PEPTICIDAL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICATIONS
IT8848133A0 (en)	1988-06-28	PREPARATION AND THEIR USE AS DERIVATIVES OF SOMATOSTATIN, THEIR MEDICINES
IT1169765B (en)	1987-06-03	DESOXYURIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICATIONS
IT8848132A0 (en)	1988-06-28	THIOUREA DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES
IT1227456B (en)	1991-04-11	NEW ALCOHOS DERIVATIVES OF GYNKOLIDS, THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS THAT CONTAIN THEM
IT1170578B (en)	1987-06-03	CHINAZOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICATIONS
IT1205360B (en)	1989-03-15	DIOLOROANILINE DERIVATIVES, PROCEDURE TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IT1197634B (en)	1988-12-06	PLEUROMUTILINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICATIONS
IT1200079B (en)	1989-01-05	NAPHTHOXYZINE DERIVATIVES, THEIR PREPARATION, THEIR APPLICATION AS MEDICATIONS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
IT1235761B (en)	1992-09-28	BICYCLICAL DERIVATIVES OF THE CATECLE, PROCEDURE FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS CONTAINING THEM
IT1189293B (en)	1988-02-04	DERIVATIVES OF 4-AMINO-BENZYLAMINE, THEIR PREPARATION AND THEIR USE AS MEDICATIONS
IT8448135A0 (en)	1984-05-04	DERIVATIVES OF ACYLAMINOPHENOLS, THEIR PREPARATION AND THEIR USE AS MEDICINES
IT8847578A0 (en)	1988-01-29	PILOCARPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES
IT1189355B (en)	1988-02-04	TRICYCLIC DERIVATIVES OF KINAZOLINONE, THEIR PREPARATION AND THEIR USE AS MEDICATIONS
IT8620135A0 (en)	1986-04-18	PROCEDURE FOR THE PREPARATION OF EBURNAMENIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
IT8522901A0 (en)	1985-11-19	DERIVATIVES OF DIHYDRUBIDECARENONE, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
IT8520439A0 (en)	1985-04-22	PREPARATION AND COMPOSITIONS OF BORNANO DERIVATIVES, THEIR THERAPEUTIC CONTAINING THE SAME.
IT8521349A0 (en)	1985-06-28	DERIVATIVES OF (+)-CYANIDANOL-3, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.