IT1277025B1 - CLASS OF PHOSPHODIESTERIC OLIGONUCLEOTIDES WITH CYTOTOXIC ACTIVITY PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE - Google Patents

CLASS OF PHOSPHODIESTERIC OLIGONUCLEOTIDES WITH CYTOTOXIC ACTIVITY PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE

Info

Publication number: IT1277025B1
Authority: IT; Italy
Prior art keywords: phosphodiesteric; oligonucleotides; class; contain; pharmaceutical compositions
Prior art date: 1995-12-04

Application number

IT95MI002539A

Other languages

Italian (it)

Inventor

Bruna Scaggiante

Franco Quadrifoglio

Original Assignee

Cooperativa Centro Ricerche Po

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-04

Filing date

1995-12-04

Publication date

1997-11-04

1995-12-04 Application filed by Cooperativa Centro Ricerche Po filed Critical Cooperativa Centro Ricerche Po

1995-12-04 Priority to IT95MI002539A priority Critical patent/IT1277025B1/en

1995-12-04 Publication of ITMI952539A0 publication Critical patent/ITMI952539A0/it

1996-12-04 Priority to PCT/EP1996/005388 priority patent/WO1997020924A1/en

1996-12-04 Priority to AU11754/97A priority patent/AU1175497A/en

1997-06-04 Publication of ITMI952539A1 publication Critical patent/ITMI952539A1/en

1997-11-04 Application granted granted Critical

1997-11-04 Publication of IT1277025B1 publication Critical patent/IT1277025B1/en

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
230000001472 cytotoxic effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Immunology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IT95MI002539A 1995-12-04 1995-12-04 CLASS OF PHOSPHODIESTERIC OLIGONUCLEOTIDES WITH CYTOTOXIC ACTIVITY PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IT1277025B1 (en)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
IT95MI002539A IT1277025B1 (en)	1995-12-04	1995-12-04	CLASS OF PHOSPHODIESTERIC OLIGONUCLEOTIDES WITH CYTOTOXIC ACTIVITY PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE
PCT/EP1996/005388 WO1997020924A1 (en)	1995-12-04	1996-12-04	A class of oligonucleotides, therapeutically useful as antitumoural agents
AU11754/97A AU1175497A (en)	1995-12-04	1996-12-04	A class of oligonucleotides, therapeutically useful as antitumoural agents

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT95MI002539A IT1277025B1 (en)	1995-12-04	1995-12-04	CLASS OF PHOSPHODIESTERIC OLIGONUCLEOTIDES WITH CYTOTOXIC ACTIVITY PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE

Publications (3)

Publication Number	Publication Date
ITMI952539A0 ITMI952539A0 (en)	1995-12-04
ITMI952539A1 ITMI952539A1 (en)	1997-06-04
IT1277025B1 true IT1277025B1 (en)	1997-11-04

Family

ID=11372654

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT95MI002539A IT1277025B1 (en)	1995-12-04	1995-12-04	CLASS OF PHOSPHODIESTERIC OLIGONUCLEOTIDES WITH CYTOTOXIC ACTIVITY PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE

Country Status (3)

Country	Link
AU (1)	AU1175497A (en)
IT (1)	IT1277025B1 (en)
WO (1)	WO1997020924A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030032610A1 (en)	1996-06-03	2003-02-13	Gilchrest Barbara A.	Method to inhibit cell growth using oligonucleotides
AU784884B2 (en)	1999-12-10	2006-07-20	Anticancer, Inc.	Methods for introducing genes into mammalian subjects
AU785212B2 (en)	1999-12-13	2006-11-09	Bioniche Life Sciences Inc.	Therapeutically useful synthetic oligonucleotides
WO2002018593A2 (en) *	2000-08-29	2002-03-07	Bioniche Life Sciences Inc.	Modulation of fas and fasl expression
US20020091095A1 (en)	1999-12-13	2002-07-11	Phillips Nigel C.	Modulation of Fas and FasL expression
WO2002020052A1 (en) *	2000-09-08	2002-03-14	Aventis Pasteur	Use of lipopeptides for immunotherapy of hiv-positive subjects
DE10230692A1 (en) *	2002-07-08	2004-02-12	Epigenomics Ag	Methods and nucleic acids for the analysis of methylation patterns within the DD3 gene
US7511131B2 (en)	2002-11-13	2009-03-31	Genzyme Corporation	Antisense modulation of apolipoprotein B expression
US7598227B2 (en)	2003-04-16	2009-10-06	Isis Pharmaceuticals Inc.	Modulation of apolipoprotein C-III expression
US20050287558A1 (en)	2004-05-05	2005-12-29	Crooke Rosanne M	SNPs of apolipoprotein B and modulation of their expression
US20100286247A1 (en) *	2005-04-04	2010-11-11	Trustees Of Boston University	Methods of Protection from Oxidative Stress
KR20090128494A (en)	2007-03-24	2009-12-15	겐자임 코포레이션	Antisense Oligonucleotide Administration Complementary to Human Apolipoprotein shock
EP2408796B1 (en)	2009-03-16	2020-04-22	Ionis Pharmaceuticals, Inc.	Targeting Apolipoprotein B for the reduction of Apolipoprotein C-III
EP2480669B1 (en) *	2009-09-25	2017-11-08	CuRNA, Inc.	Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity
WO2011081884A1 (en) *	2009-12-14	2011-07-07	Massachusetts Institute Of Technology	Systems and methods related to optical nanosensors including photoluminescent nanostructures
IT1405761B1 (en)	2010-09-13	2014-01-24	Univ Degli Studi Trieste	GT APTAMERIC OLIGONUCLEOTIDS AND THEIR USE AS ANTI-HUMAN AGENTS
AU2012249324B2 (en)	2011-04-27	2016-10-06	Ionis Pharmaceuticals, Inc.	Modulation of apolipoprotein CIII (ApoCIII) expression
TWI876659B (en) *	2022-11-29	2025-03-11	法信諾生醫股份有限公司	Oligonucleotide therapeutics and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994007367A1 (en) *	1992-09-29	1994-04-14	Apollon, Inc.	Anti-viral oligomers that bind polypurine tracts of single-stranded rna or rna-dna hybrids
EP0713705A4 (en) *	1994-03-25	1998-09-02	Akira Kaji	Novel anti-hiv drug
WO1996011010A1 (en) *	1994-10-07	1996-04-18	Pharmagenics, Inc.	Bridged and unbridged quadruplex/duplex oligonucleotides
WO1996024380A1 (en) *	1995-02-09	1996-08-15	Icn Pharmaceuticals, Inc.	Methods and compositions for regulation of cd28 expression

1995
- 1995-12-04 IT IT95MI002539A patent/IT1277025B1/en active IP Right Grant
1996
- 1996-12-04 WO PCT/EP1996/005388 patent/WO1997020924A1/en not_active Ceased
- 1996-12-04 AU AU11754/97A patent/AU1175497A/en not_active Abandoned

Also Published As

Publication number	Publication date
ITMI952539A0 (en)	1995-12-04
ITMI952539A1 (en)	1997-06-04
AU1175497A (en)	1997-06-27
WO1997020924A1 (en)	1997-06-12

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Legal Events

Date	Code	Title	Description
1997-11-04	0001	Granted