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IT1270122B - 6-BENZYL-4-OXYPYRIMIDIN REPLACED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

6-BENZYL-4-OXYPYRIMIDIN REPLACED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
IT1270122B
IT1270122B ITMI942023A ITMI942023A IT1270122B IT 1270122 B IT1270122 B IT 1270122B IT MI942023 A ITMI942023 A IT MI942023A IT MI942023 A ITMI942023 A IT MI942023A IT 1270122 B IT1270122 B IT 1270122B
Authority
IT
Italy
Prior art keywords
preparation
benzyl
pharmaceutical compositions
oxypyrimidin
replaced
Prior art date
Application number
ITMI942023A
Other languages
Italian (it)
Inventor
Marino Artico
Silvio Massa
Antonello Mai
Colla Paolo La
Maria Elena Marongiu
Enzo Tramontano
Original Assignee
Ist Superiore Sanita
Univ Cagliari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ist Superiore Sanita, Univ Cagliari filed Critical Ist Superiore Sanita
Priority to ITMI942023A priority Critical patent/IT1270122B/en
Publication of ITMI942023A0 publication Critical patent/ITMI942023A0/en
Priority to AU38036/95A priority patent/AU3803695A/en
Priority to PCT/EP1995/003912 priority patent/WO1996010565A1/en
Publication of ITMI942023A1 publication Critical patent/ITMI942023A1/en
Application granted granted Critical
Publication of IT1270122B publication Critical patent/IT1270122B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Sono descritte 6-benzil-4-ossopirimidine sostituite di formula (I) (FORMULA I) in cui:X è scelto nel gruppo costituito da O, S;R è scelto nel gruppo costituito da C1-4 alchile, C5-6 cicloalchile;R', R" e Z, uguali o diversi fra loro indicano H, C1-4 alchile considerando che quando X = O R ed R' non possono essere entrambi uguali a H;loro sali farmaceuticamente accettabili e loro derivati solubili;un loro processo di preparazione ed il loro uso per la preparazione di composizioni farmaceutiche utili per il trattamento di infezioni virali.Substituted 6-benzyl-4-oxopyrimidines of formula (I) (FORMULA I) are described wherein: X is selected from the group consisting of O, S; R is selected from the group consisting of C1-4 alkyl, C5-6 cycloalkyl; R ', R "and Z, equal or different from each other, indicate H, C1-4 alkyl considering that when X = OR and R' cannot both be equal to H; their pharmaceutically acceptable salts and their soluble derivatives; a process of their preparation and their use for the preparation of pharmaceutical compositions useful for the treatment of viral infections.

ITMI942023A 1994-10-04 1994-10-04 6-BENZYL-4-OXYPYRIMIDIN REPLACED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IT1270122B (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ITMI942023A IT1270122B (en) 1994-10-04 1994-10-04 6-BENZYL-4-OXYPYRIMIDIN REPLACED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU38036/95A AU3803695A (en) 1994-10-04 1995-10-04 Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them
PCT/EP1995/003912 WO1996010565A1 (en) 1994-10-04 1995-10-04 Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942023A IT1270122B (en) 1994-10-04 1994-10-04 6-BENZYL-4-OXYPYRIMIDIN REPLACED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (3)

Publication Number Publication Date
ITMI942023A0 ITMI942023A0 (en) 1994-10-04
ITMI942023A1 ITMI942023A1 (en) 1996-04-04
IT1270122B true IT1270122B (en) 1997-04-28

Family

ID=11369647

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI942023A IT1270122B (en) 1994-10-04 1994-10-04 6-BENZYL-4-OXYPYRIMIDIN REPLACED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (3)

Country Link
AU (1) AU3803695A (en)
IT (1) IT1270122B (en)
WO (1) WO1996010565A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007027A2 (en) * 1999-07-22 2001-02-01 Vertex Pharmaceuticals Incorporated Pyrimidine derivatives for the treatment of viral diseases
CN100439343C (en) * 2006-08-04 2008-12-03 复旦大学 2-Alkylthio-5-alkyl-6-(1-cyanoarylmethyl) substituted uracil compounds and their preparation methods and uses
CN100519540C (en) * 2007-01-09 2009-07-29 云南大学 S-DABO compound, synthesizing method and usage

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4612376A (en) * 1983-03-25 1986-09-16 Fujisawa Pharmaceutical Co., Ltd. Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
GB9012592D0 (en) * 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds

Also Published As

Publication number Publication date
WO1996010565A1 (en) 1996-04-11
ITMI942023A1 (en) 1996-04-04
ITMI942023A0 (en) 1994-10-04
AU3803695A (en) 1996-04-26

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Legal Events

Date Code Title Description
0001 Granted