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IT1262895B - Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. - Google Patents

Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.

Info

Publication number
IT1262895B
IT1262895B ITFI920052A ITFI920052A IT1262895B IT 1262895 B IT1262895 B IT 1262895B IT FI920052 A ITFI920052 A IT FI920052A IT FI920052 A ITFI920052 A IT FI920052A IT 1262895 B IT1262895 B IT 1262895B
Authority
IT
Italy
Prior art keywords
protein
vaccine
helicobacter pylori
diagnostic purposes
gene expressing
Prior art date
Application number
ITFI920052A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ITFI920052A0 publication Critical patent/ITFI920052A0/it
Priority to ITFI920052A priority Critical patent/IT1262895B/it
Priority to EP99202698A priority patent/EP0967279B1/en
Priority to AT93905285T priority patent/ATE245698T1/de
Priority to JP51530993A priority patent/JP3368902B2/ja
Priority to DE69333110T priority patent/DE69333110T2/de
Priority to AT99202698T priority patent/ATE382692T1/de
Priority to AU36300/93A priority patent/AU3630093A/en
Priority to PCT/EP1993/000472 priority patent/WO1993018150A1/en
Priority to EP93905285A priority patent/EP0643770B1/en
Priority to CA002383007A priority patent/CA2383007A1/en
Priority to DE69334197T priority patent/DE69334197T2/de
Priority to SG1996009100A priority patent/SG48353A1/en
Priority to CA002131729A priority patent/CA2131729C/en
Publication of ITFI920052A1 publication Critical patent/ITFI920052A1/it
Priority to US08/471,491 priority patent/US6090611A/en
Priority to US08/466,662 priority patent/US6130059A/en
Priority to US08/470,260 priority patent/US6077706A/en
Priority to US08/477,451 priority patent/US5928865A/en
Application granted granted Critical
Publication of IT1262895B publication Critical patent/IT1262895B/it
Priority to US09/360,685 priority patent/US7141244B1/en
Priority to JP2000126695A priority patent/JP3408494B2/ja
Priority to JP2000126696A priority patent/JP2000333686A/ja
Priority to US09/921,157 priority patent/US20040048353A1/en
Priority to JP2003008806A priority patent/JP4271952B2/ja
Priority to US10/615,668 priority patent/US7700755B2/en
Priority to JP2005263068A priority patent/JP2006055168A/ja
Priority to US11/580,632 priority patent/US20070243204A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Sono descritti una nuova proteina estratta da ceppi citotossici di Helicobacter pylori avente un peso molecolare di circa 130 kDa determinato con gel poliacrilamide in SDS, il gene che esprime detta proteina ed il suo uso come vaccino o diagnostico.
ITFI920052A 1992-03-02 1992-03-02 Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. IT1262895B (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
ITFI920052A IT1262895B (it) 1992-03-02 1992-03-02 Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.
CA002131729A CA2131729C (en) 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics
AT93905285T ATE245698T1 (de) 1992-03-02 1993-03-02 Mit dem cytotoxin von helicobacter pylori assoziiertes, immunodominantes antigen verwendbar in impfstoffen und zur diagnose
JP51530993A JP3368902B2 (ja) 1992-03-02 1993-03-02 ワクチンおよび診断に有用なＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉタンパク質
DE69333110T DE69333110T2 (de) 1992-03-02 1993-03-02 Mit dem cytotoxin von helicobacter pylori assoziiertes, immunodominantes antigen verwendbar in impfstoffen und zur diagnose
AT99202698T ATE382692T1 (de) 1992-03-02 1993-03-02 Helicobacter pylori cytotoxin verwendbar in impfstoffe und diagnostik
AU36300/93A AU3630093A (en) 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics
PCT/EP1993/000472 WO1993018150A1 (en) 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics
EP93905285A EP0643770B1 (en) 1992-03-02 1993-03-02 Helicobacter pylori cytotoxin associated immunodominant antigen useful for vaccines and diagnostics
CA002383007A CA2383007A1 (en) 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics
DE69334197T DE69334197T2 (de) 1992-03-02 1993-03-02 Helicobacter pylori Cytotoxin verwendbar in Impfstoffe und Diagnostik
SG1996009100A SG48353A1 (en) 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics
EP99202698A EP0967279B1 (en) 1992-03-02 1993-03-02 Helicobacter pylori cytotoxin useful for vaccines and diagnostics
US08/470,260 US6077706A (en) 1992-03-02 1995-06-06 Helicobacter pylori proteins useful for vaccines and diagnostics
US08/471,491 US6090611A (en) 1992-03-02 1995-06-06 Helicobacter pylori proteins useful for vaccines and diagnostics
US08/466,662 US6130059A (en) 1992-03-02 1995-06-06 Helicobacter pylori proteins useful for vaccines and diagnostics
US08/477,451 US5928865A (en) 1992-03-02 1995-06-07 Compositions comprising isolated Helicobacter pylori CagI polynucleotides and method of preparation thereof
US09/360,685 US7141244B1 (en) 1992-03-02 1999-07-26 Helicobacter pylori proteins useful for vaccines and diagnostics
JP2000126695A JP3408494B2 (ja) 1992-03-02 2000-04-26 ワクチンおよび診断に有用なＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉタンパク質
JP2000126696A JP2000333686A (ja) 1992-03-02 2000-04-26 ワクチンおよび診断に有用なＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉタンパク質
US09/921,157 US20040048353A1 (en) 1992-03-02 2001-08-02 Helicobacter pylori proteins useful for vaccines and diagnostics
JP2003008806A JP4271952B2 (ja) 1992-03-02 2003-01-16 ワクチンおよび診断に有用なＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉタンパク質
US10/615,668 US7700755B2 (en) 1992-03-02 2003-07-08 Helicobacter pylori CAI antigen
JP2005263068A JP2006055168A (ja) 1992-03-02 2005-09-09 ワクチンおよび診断に有用なＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉタンパク質
US11/580,632 US20070243204A1 (en) 1992-03-02 2006-10-12 Helicobacter pylori proteins useful for vaccines and diagnostics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITFI920052A IT1262895B (it) 1992-03-02 1992-03-02 Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.

Publications (3)

Publication Number Publication Date
ITFI920052A0 ITFI920052A0 (it) 1992-03-02
ITFI920052A1 ITFI920052A1 (it) 1993-09-02
IT1262895B true IT1262895B (it) 1996-07-22

Family

ID=11349982

Family Applications (1)

Application Number Title Priority Date Filing Date
ITFI920052A IT1262895B (it) 1992-03-02 1992-03-02 Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.

Country Status (6)

Country Link
US (1) US6090611A (it)
EP (1) EP0643770B1 (it)
JP (1) JP4271952B2 (it)
AT (2) ATE382692T1 (it)
IT (1) IT1262895B (it)
SG (1) SG48353A1 (it)

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Publication number Priority date Publication date Assignee Title
WO1993018150A1 (en) * 1992-03-02 1993-09-16 Biocine S.P.A. Helicobacter pylori proteins useful for vaccines and diagnostics
US7141244B1 (en) * 1992-03-02 2006-11-28 Chiron Srl Helicobacter pylori proteins useful for vaccines and diagnostics
EP0769018B1 (en) * 1994-07-01 2002-12-18 Chiron Corporation Helicobacter proteins and vaccines
DE69737413T2 (de) * 1996-01-04 2007-10-31 Novartis Vaccines and Diagnostics, Inc., Emeryville Bakterioferritin aus helicobacter pylori
US7517952B1 (en) * 1997-02-25 2009-04-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US20060024301A1 (en) * 1997-02-25 2006-02-02 Corixa Corporation Prostate-specific polypeptides and fusion polypeptides thereof
US20030185830A1 (en) * 1997-02-25 2003-10-02 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US20060269532A1 (en) * 1997-02-25 2006-11-30 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
AU3439799A (en) 1998-04-30 1999-11-23 Chiron S.P.A. Immunization against and treatment for infection by (h.pylori)
US6764687B1 (en) * 1999-06-09 2004-07-20 Akzo Nobel N.V. Live attenuated bacteria for use in a vaccine
US7179609B1 (en) 2000-10-04 2007-02-20 Atrophus Ab Screening method for gastritis
US7048931B1 (en) 2000-11-09 2006-05-23 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US20020107368A1 (en) * 2000-12-07 2002-08-08 Jing-Hui Tian Helicobacter proteins, gene sequences and uses thereof
US20050175629A1 (en) * 2001-08-31 2005-08-11 Giuseppe Del Giudice Helicobacter pylori vaccination
SE0200974D0 (sv) 2002-03-27 2002-03-27 Phagen Ab Screening method for gastritis
US20060078919A1 (en) * 2004-09-08 2006-04-13 Harry C. Gurney Janice Gurney Diagnostic test kit and methods of diagnosis and treatment of helicobacter SPP. associated infections
US8809494B2 (en) 2004-11-17 2014-08-19 Drexel University Method and compositions for prevention and treatment of malaria infections
US9568471B2 (en) * 2005-01-25 2017-02-14 The Johns Hopkins University Plasmodium diagnostic assay device
ES2532942T3 (es) 2006-03-01 2015-04-06 Aduro Biotech Listeria obtenida por ingeniería genética y métodos de uso de la misma
HUE039747T2 (hu) 2010-11-17 2019-02-28 Aduro Biotech Inc Eljárások és kompozíciók EGFRVIII-ra való immunválasz indukálására
JP2014518620A (ja) 2011-04-26 2014-08-07 モレキュラー エクスプレス，インコーポレイテッド リポソーム製剤
KR20150022996A (ko) 2012-06-08 2015-03-04 아두로 바이오테크 암 면역요법을 위한 조성물 및 방법
AU2013341242B2 (en) 2012-11-06 2018-06-28 Aduro Biotech, Inc. Facultatively attenuated bacterial species and methods of preparation and use thereof
SG10201704611WA (en) 2012-12-13 2017-07-28 Aduro Biotech Inc Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
MX2015008329A (es) 2012-12-27 2016-03-01 Aduro Biotech Inc Compañeros de fusion de peptido, señal que facilita la expresion listeral de secuencias antigenicas y metodos de preparacion y uso de los mismos.
AU2014260015B2 (en) 2013-04-29 2019-11-14 Memorial Sloan Kettering Cancer Center Compositions and methods for altering second messenger signaling
ES2822584T3 (es) 2013-05-03 2021-05-04 Univ California Inducción de dinucleótidos cíclicos del interferón tipo I
US9549944B2 (en) 2013-05-18 2017-01-24 Aduro Biotech, Inc. Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
CA2904536A1 (en) 2013-05-18 2014-11-27 Aduro Biotech, Inc. Compositions and methods for activating "stimulator of interferon gene"-dependent signalling
US10176292B2 (en) 2013-07-31 2019-01-08 Memorial Sloan-Kettering Cancer Center STING crystals and modulators
WO2016061115A1 (en) 2014-10-13 2016-04-21 Providence Health & Services-Oregon D/B/A Providence Portland Medical Center Bacterial vaccines deficient in the 2-c-methyl-d-erythritol-4-phosphate pathway and methods of preparation and use thereof
WO2016073381A1 (en) 2014-11-03 2016-05-12 Cerus Corporation Compositions and methods for improved car-t cell therapies

Family Cites Families (7)

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US5459041A (en) * 1988-02-18 1995-10-17 Enteric Research Laboratories, Inc. Campylobacter pylori antigens and uses thereof for detection of Campylobacter pylori infection
US4882271A (en) * 1988-03-10 1989-11-21 Baylor College Of Medicine Process for preparation of high molecular weight cell-associated protein of campylobacter pylori and use for serological detection of campylobacter pylori infection
FR2637612B1 (fr) * 1988-10-06 1993-09-10 Pasteur Institut Sequences de nucleotides codant pour une proteine a activite ureasique
GB8928625D0 (en) * 1989-12-19 1990-02-21 3I Res Expl Ltd H.pylori dna probes
US5292658A (en) * 1989-12-29 1994-03-08 University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center Cloning and expressions of Renilla luciferase
US5354854A (en) * 1991-11-07 1994-10-11 The Curators Of The University Of Missouri Expression system for use in plants to suppress foreign expression and method
US5403924A (en) * 1992-10-13 1995-04-04 Vanderbilt University Taga gene and methods for detecting predisposition to peptic ulceration

Also Published As

Publication number Publication date
US6090611A (en) 2000-07-18
ITFI920052A1 (it) 1993-09-02
ATE245698T1 (de) 2003-08-15
EP0643770A1 (en) 1995-03-22
JP4271952B2 (ja) 2009-06-03
SG48353A1 (en) 1998-04-17
ITFI920052A0 (it) 1992-03-02
JP2003199567A (ja) 2003-07-15
EP0643770B1 (en) 2003-07-23
ATE382692T1 (de) 2008-01-15

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19980327