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IT1255462B - METHOD OF PREPARATION OF NIMESULIDE INCLUSION COMPOUNDS WITH CYCLODESTRINE - Google Patents

METHOD OF PREPARATION OF NIMESULIDE INCLUSION COMPOUNDS WITH CYCLODESTRINE

Info

Publication number
IT1255462B
IT1255462B ITMI921833A ITMI921833A IT1255462B IT 1255462 B IT1255462 B IT 1255462B IT MI921833 A ITMI921833 A IT MI921833A IT MI921833 A ITMI921833 A IT MI921833A IT 1255462 B IT1255462 B IT 1255462B
Authority
IT
Italy
Prior art keywords
nimesulide
preparation
cyclodestrine
inclusion compounds
milling
Prior art date
Application number
ITMI921833A
Other languages
Italian (it)
Inventor
Grazia Maffione
Original Assignee
Grazia Maffione
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grazia Maffione filed Critical Grazia Maffione
Priority to ITMI921833A priority Critical patent/IT1255462B/en
Publication of ITMI921833A0 publication Critical patent/ITMI921833A0/en
Priority to PCT/EP1993/001560 priority patent/WO1994002177A1/en
Publication of ITMI921833A1 publication Critical patent/ITMI921833A1/en
Application granted granted Critical
Publication of IT1255462B publication Critical patent/IT1255462B/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Si descrive un metodo per la preparazione di composti di inclusione di nimesulide con ciclodestrine che consiste nel sottoporre una miscela solida, una soluzione acquosa o un impasto omogeneo di nimesulide e ciclodestrina idrosolubile rispettivamente a co-mulinazione, essiccamento spray o mulinazione ed essiccazione.A method for the preparation of inclusion compounds of nimesulide with cyclodextrins is described which consists in subjecting a solid mixture, an aqueous solution or a homogeneous mixture of nimesulide and water soluble cyclodextrin to co-milling, spray drying or milling and drying respectively.

ITMI921833A 1992-07-28 1992-07-28 METHOD OF PREPARATION OF NIMESULIDE INCLUSION COMPOUNDS WITH CYCLODESTRINE IT1255462B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITMI921833A IT1255462B (en) 1992-07-28 1992-07-28 METHOD OF PREPARATION OF NIMESULIDE INCLUSION COMPOUNDS WITH CYCLODESTRINE
PCT/EP1993/001560 WO1994002177A1 (en) 1992-07-28 1993-06-18 Method of preparation of inclusion compounds of nimesulide with cyclodextrins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI921833A IT1255462B (en) 1992-07-28 1992-07-28 METHOD OF PREPARATION OF NIMESULIDE INCLUSION COMPOUNDS WITH CYCLODESTRINE

Publications (3)

Publication Number Publication Date
ITMI921833A0 ITMI921833A0 (en) 1992-07-28
ITMI921833A1 ITMI921833A1 (en) 1994-01-28
IT1255462B true IT1255462B (en) 1995-11-02

Family

ID=11363762

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI921833A IT1255462B (en) 1992-07-28 1992-07-28 METHOD OF PREPARATION OF NIMESULIDE INCLUSION COMPOUNDS WITH CYCLODESTRINE

Country Status (2)

Country Link
IT (1) IT1255462B (en)
WO (1) WO1994002177A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA57734C2 (en) 1996-05-07 2003-07-15 Пфайзер Інк. Arylheterocyclic inclusion complexes
IT1298732B1 (en) * 1998-03-13 2000-02-02 Recordati Chem Pharm ORAL PHARMACEUTICAL COMPOSITIONS ASSUMABLE WITHOUT LIQUIDS, CONTAINING INCLUSION COMPLEXES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1227626B (en) * 1988-11-28 1991-04-23 Vectorpharma Int SUPPORTED DRUGS WITH INCREASED DISSOLUTION SPEED AND PROCEDURE FOR THEIR PREPARATION
ES2023552A6 (en) * 1990-05-22 1992-01-16 Leetrim Limited Nimesulid inclusion cpds. with cyclodextrin - more water-soluble with improved bio-availability than nimesulid alone
IT1248475B (en) * 1990-05-22 1995-01-19 Angeli Inst Spa INCLUSION COMPOUNDS OF NIMESULIDE WITH CYCLODESTRINE

Also Published As

Publication number Publication date
ITMI921833A0 (en) 1992-07-28
WO1994002177A1 (en) 1994-02-03
ITMI921833A1 (en) 1994-01-28

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Legal Events

Date Code Title Description
0001 Granted