IT1250689B - ANALOGUES OF IRUDINA AND PROCEDURE FOR THEIR PREPARATION - Google Patents
ANALOGUES OF IRUDINA AND PROCEDURE FOR THEIR PREPARATIONInfo
- Publication number
- IT1250689B IT1250689B ITMI912019A ITMI912019A IT1250689B IT 1250689 B IT1250689 B IT 1250689B IT MI912019 A ITMI912019 A IT MI912019A IT MI912019 A ITMI912019 A IT MI912019A IT 1250689 B IT1250689 B IT 1250689B
- Authority
- IT
- Italy
- Prior art keywords
- analogues
- irudina
- procedure
- preparation
- gly
- Prior art date
Links
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 208000005189 Embolism Diseases 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical class C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invenzione si riferisce a polipepti di analoghi dell'irudina aventi la seguente formula (I)P-(Gly)n-X (I)dove P è un residuo polipeptidico HV1 o HV1(Val65), avente le sequenze aminoacidiche definite in Figura l;-(Gly)- è il radicale bivalente della glicina -NH-CH2-CO-;X è -OH o -NH2 e n è zero o 1,con la condizione che, quando P è HV1 ed n è zero, X è solo -NH2, e che, quando n è 1, X è solo -OH, ed ai sali farmaceuticamente accettabili dei composti di formula (I). I polipeptidi dell'invenzione sono utili nel trattamento di eventi tromboembolici.The present invention relates to polypepts of hirudin analogues having the following formula (I) P- (Gly) nX (I) where P is a polypeptide residue HV1 or HV1 (Val65), having the amino acid sequences defined in Figure 1; - (Gly) - is the bivalent radical of glycine -NH-CH2-CO-; X is -OH or -NH2 en is zero or 1, with the proviso that, when P is HV1 and n is zero, X is only - NH2, and that, when n is 1, X is only -OH, and to the pharmaceutically acceptable salts of the compounds of formula (I). The polypeptides of the invention are useful in the treatment of thromboembolic events.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI912019A IT1250689B (en) | 1991-07-22 | 1991-07-22 | ANALOGUES OF IRUDINA AND PROCEDURE FOR THEIR PREPARATION |
| FR9209045A FR2679565B1 (en) | 1991-07-22 | 1992-07-22 | HIRUDINE ANALOGS, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS. |
| GB9215552A GB2257974B (en) | 1991-07-22 | 1992-07-22 | Hirudin analogues and process for their preparation |
| DE4224213A DE4224213A1 (en) | 1991-07-22 | 1992-07-22 | HIRUDINANALOGES AND METHOD FOR THEIR PRODUCTION |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI912019A IT1250689B (en) | 1991-07-22 | 1991-07-22 | ANALOGUES OF IRUDINA AND PROCEDURE FOR THEIR PREPARATION |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI912019A0 ITMI912019A0 (en) | 1991-07-22 |
| ITMI912019A1 ITMI912019A1 (en) | 1993-01-22 |
| IT1250689B true IT1250689B (en) | 1995-04-21 |
Family
ID=11360396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI912019A IT1250689B (en) | 1991-07-22 | 1991-07-22 | ANALOGUES OF IRUDINA AND PROCEDURE FOR THEIR PREPARATION |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE4224213A1 (en) |
| FR (1) | FR2679565B1 (en) |
| GB (1) | GB2257974B (en) |
| IT (1) | IT1250689B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL101062A0 (en) * | 1991-02-28 | 1992-11-15 | Erba Carlo Spa | Anti-thrombin polypeptides and their preparation |
| DE4404168A1 (en) * | 1994-02-10 | 1995-08-17 | Hoechst Ag | Hirudin derivatives and process for their preparation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341032C (en) * | 1987-01-23 | 2000-06-20 | John L. Krstenansky | Anticoagulant peptides |
| JP2653820B2 (en) * | 1988-03-14 | 1997-09-17 | 壽之 松尾 | Amidating enzyme and method for producing the same |
| GB8916289D0 (en) * | 1989-07-17 | 1989-08-31 | Erba Carlo Spa | Cofactor for the pam enzyme |
| ZA907742B (en) * | 1989-10-03 | 1991-07-31 | Merrell Dow Pharma | Anticoagulant peptides |
-
1991
- 1991-07-22 IT ITMI912019A patent/IT1250689B/en active IP Right Grant
-
1992
- 1992-07-22 GB GB9215552A patent/GB2257974B/en not_active Expired - Fee Related
- 1992-07-22 FR FR9209045A patent/FR2679565B1/en not_active Expired - Fee Related
- 1992-07-22 DE DE4224213A patent/DE4224213A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE4224213A1 (en) | 1993-01-28 |
| FR2679565B1 (en) | 1995-02-03 |
| GB9215552D0 (en) | 1992-09-02 |
| FR2679565A1 (en) | 1993-01-29 |
| GB2257974A (en) | 1993-01-27 |
| ITMI912019A0 (en) | 1991-07-22 |
| ITMI912019A1 (en) | 1993-01-22 |
| GB2257974B (en) | 1995-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970626 |