[go: up one dir, main page]

IT1249211B - Process for the preparation of triazolyl isopropanols, in particular fluconazole - Google Patents

Process for the preparation of triazolyl isopropanols, in particular fluconazole

Info

Publication number
IT1249211B
IT1249211B IT02058690A IT2058690A IT1249211B IT 1249211 B IT1249211 B IT 1249211B IT 02058690 A IT02058690 A IT 02058690A IT 2058690 A IT2058690 A IT 2058690A IT 1249211 B IT1249211 B IT 1249211B
Authority
IT
Italy
Prior art keywords
isopropanols
triazolyl
preparation
fluconazole
particular fluconazole
Prior art date
Application number
IT02058690A
Other languages
Italian (it)
Other versions
IT9020586A0 (en
IT9020586A1 (en
Inventor
Fulvio Benigni
Rino Prendin
Original Assignee
Ind Chimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of IT9020586A0 publication Critical patent/IT9020586A0/it
Application filed by Ind Chimica Srl filed Critical Ind Chimica Srl
Priority to IT02058690A priority Critical patent/IT1249211B/en
Priority to ES9002961A priority patent/ES2026416A6/en
Priority to AT113291A priority patent/AT400145B/en
Priority to YU101291A priority patent/YU48331B/en
Priority to CA 2051281 priority patent/CA2051281C/en
Publication of IT9020586A1 publication Critical patent/IT9020586A1/en
Application granted granted Critical
Publication of IT1249211B publication Critical patent/IT1249211B/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

An improved method is described for the synthesis of fluconazole by reaction of a halohydrin intermediate with 4- amino-1,2,4-triazole with subsequent deamination with nitrous acid.
IT02058690A 1990-06-08 1990-06-08 Process for the preparation of triazolyl isopropanols, in particular fluconazole IT1249211B (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT02058690A IT1249211B (en) 1990-06-08 1990-06-08 Process for the preparation of triazolyl isopropanols, in particular fluconazole
ES9002961A ES2026416A6 (en) 1990-06-08 1990-11-21 Procedure for the preparation of triazolil-isopropanol. (Machine-translation by Google Translate, not legally binding)
AT113291A AT400145B (en) 1990-06-08 1991-06-05 METHOD FOR PRODUCING TRIAZOLYL ISOPROPANOLS
YU101291A YU48331B (en) 1990-06-08 1991-06-06 PROCEDURE FOR OBTAINING TRIAZOLYL-ISOPROPANOL
CA 2051281 CA2051281C (en) 1990-06-08 1991-09-13 Process for the preparation of triazolyl isopropanols

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02058690A IT1249211B (en) 1990-06-08 1990-06-08 Process for the preparation of triazolyl isopropanols, in particular fluconazole

Publications (3)

Publication Number Publication Date
IT9020586A0 IT9020586A0 (en) 1990-06-07
IT9020586A1 IT9020586A1 (en) 1991-12-08
IT1249211B true IT1249211B (en) 1995-02-20

Family

ID=11169192

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02058690A IT1249211B (en) 1990-06-08 1990-06-08 Process for the preparation of triazolyl isopropanols, in particular fluconazole

Country Status (5)

Country Link
AT (1) AT400145B (en)
CA (1) CA2051281C (en)
ES (1) ES2026416A6 (en)
IT (1) IT1249211B (en)
YU (1) YU48331B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2049663B1 (en) * 1992-10-13 1994-12-16 Genesis Para La Investigacion PROCEDURE FOR OBTAINING FLUCONAZOLE.
IL105200A (en) * 1993-03-29 1997-03-18 Teva Pharma Regiospecific processes for the preparation of 1, 3-bis (1, 2, 4-triazol-1-yl)-propan- 2-ol derivatives
HU212424B (en) * 1993-09-23 1996-06-28 Richter Gedeon Vegyeszet New propan-2-ol derivatives substituted with triazole or imidazole and process for producing them
SI9600165A (en) * 1996-05-21 1997-12-31 Krka Tovarna Zdravil D D Novo Process for preparation of biological active derivative of 1,2,4- triazole and intermediates useful in this process
HU226886B1 (en) * 2001-03-23 2010-01-28 Richter Gedeon Nyrt Novel process for preparing fluconazole monohydrate
AU2003242638A1 (en) * 2002-06-24 2004-01-06 Basf Aktiengesellschaft Method for the production of 1,2,4-triazolylmethyl-oxiranes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79307B (en) * 1982-06-09 1984-10-22 Pfizer
ES8604939A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl) 1,3-bis (1H-triazolyl) propan-2-ol prepn.
ES8604938A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl)-1,3-bis(triazolyl) propan-2-ol prepn.
ES8604940A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl) 1,3-bis(1H-triazolyl) propan-2-ol prepn.
ES8605753A1 (en) * 1985-12-06 1986-04-16 Lazlo Int Sa Di-triazolyl:methyl di:fluoro-phenyl carbinol prepn.

Also Published As

Publication number Publication date
IT9020586A0 (en) 1990-06-07
AT400145B (en) 1995-10-25
IT9020586A1 (en) 1991-12-08
CA2051281C (en) 1998-07-07
YU101291A (en) 1993-11-16
ATA113291A (en) 1995-02-15
CA2051281A1 (en) 1993-03-14
YU48331B (en) 1998-05-15
ES2026416A6 (en) 1992-04-16

Similar Documents

Publication Publication Date Title
HU906493D0 (en) Process for producing substituted 1,2,4-triazole derivatives and pharmaceutical preparatives containing these compounds
AU7865691A (en) Process for producing 1,4-bis-(fluorbenzoyl)-benzol
DE69314492D1 (en) METHOD FOR PRODUCING INDOLDER DERIVATIVES CONTAINING A 1,2,4-TRIAZOL-1-YL SUBSTITUENT
IT1249211B (en) Process for the preparation of triazolyl isopropanols, in particular fluconazole
HU9302360D0 (en) Method for producing imidazole derivatives
GR3003445T3 (en) Process for the preparation of 1-hydroxyalkyl-5-nitro-imidazoles
HUT58703A (en) Process for producing 3-methyl-pyrazol and derivatives
HUT49587A (en) Process for producing 1-hydroxyalkyl-5-nitroimidazoles
BR9705433A (en) Process for the preparation of 4-amino-1,2,4-triazole
HUT52074A (en) Process for producing 5-amino-1,2,4-triazole-3-sulfonamide derivatives
HUT45238A (en) Process for producing 6-amino-3-hydrazino-pyridazine derivatives
SG50476A1 (en) Process for preparing enantiomerically pure 6-[(4-chlorophenyl) (1H-1,2,4-triazol-1-yl) methyl]-1-methyl-1H-benzotriazole
HUT54665A (en) Process for producing 4-amino-1,2,4-triazol-5-one derivatives
HU9303375D0 (en) Process for producing 5-(3-butyryl-2,4,6-trimethyl-phenyl)-2-(ethoxy-imino)-propyl)-3-hyoroxy-cyclohex-2-en-1-on
HU903953D0 (en) Process for producing imidazole derivatives
JPS6475485A (en) Bisnitrourea derivative and antitumor agent
PL237053A1 (en) Process for preparing novel 1-substituted imidazo-/1,2-a/imidazoles
ES2020785A6 (en) Process for obtaining 1,3-bis(1H-1,2,4-triazol-1-yl)- propan-2-one
JPS57116067A (en) Novel 8-quinolinesulfonyl derivative, its synthesis and use
AU8499291A (en) Process for the production of 1,2,4-triazol-5-one
YU18988A (en) Process for preparing derivatives of aralkyl-4h-1,2,4-triazole
YU127989A (en) Process for preparing derivatives of aralkyl-4h-1,2,4-triazole
CS563790A3 (en) Process for preparing dichloropropanol solution
ES2001449A6 (en) New bifonazole synthesis method (Machine-translation by Google Translate, not legally binding)
HUT74177A (en) Process for producing 2-phenyl-3,3,3-trifluoro-propionic acid

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970626