IT1123321B - Synergistic antibiotic compsns. - Google Patents
Synergistic antibiotic compsns.Info
- Publication number
- IT1123321B IT1123321B IT25973/79A IT2597379A IT1123321B IT 1123321 B IT1123321 B IT 1123321B IT 25973/79 A IT25973/79 A IT 25973/79A IT 2597379 A IT2597379 A IT 2597379A IT 1123321 B IT1123321 B IT 1123321B
- Authority
- IT
- Italy
- Prior art keywords
- acid
- compsns
- antibiotic
- esp
- alkyl
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 3
- 230000002195 synergetic effect Effects 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 150000004718 beta keto acids Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- KYGZCKSPAKDVKC-UHFFFAOYSA-N Oxolinic acid Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC2=C1OCO2 KYGZCKSPAKDVKC-UHFFFAOYSA-N 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- VDUWPHTZYNWKRN-UHFFFAOYSA-N cinoxacin Chemical compound C1=C2N(CC)N=C(C(O)=O)C(=O)C2=CC2=C1OCO2 VDUWPHTZYNWKRN-UHFFFAOYSA-N 0.000 abstract 1
- 125000005331 diazinyl group Chemical group N1=NC(=CC=C1)* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000004715 keto acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960000210 nalidixic acid Drugs 0.000 abstract 1
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 abstract 1
- 229960000321 oxolinic acid Drugs 0.000 abstract 1
- 229960001732 pipemidic acid Drugs 0.000 abstract 1
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 abstract 1
- 229960004444 piromidic acid Drugs 0.000 abstract 1
- RCIMBBZXSXFZBV-UHFFFAOYSA-N piromidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCCC1 RCIMBBZXSXFZBV-UHFFFAOYSA-N 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compositions contg. an antibiotic (I) and a beta keto acid (II) are new. (Where A = CH or N ; B = a benzene, azine or diazine group, opt. substd. by a 1-4C alkyl or alkoxy group, halogens, dioxymethylene or saturated heterocyclic groups; R = H or alkyl). The keto acid (II) is pref. nalidixic acid, oxolinic acid, cinoxacine, piromidic acid, or pipemidic acid. The antibiotic (I) is usually a tetracycline or cephalosporin, esp. pivcephalexine, cephadroxyl, or cefatrixine. Compsns. are active against Gram positive and negative bacteria, esp. resistant strains.
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT25973/79A IT1123321B (en) | 1979-09-25 | 1979-09-25 | Synergistic antibiotic compsns. |
| CH909979A CH642850A5 (en) | 1978-10-20 | 1979-10-09 | PHARMACEUTICAL COMPOSITIONS WITH ANTIBACTERIAL ACTIVITY AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE GERM INFECTIONS. |
| PH23158A PH15745A (en) | 1978-10-20 | 1979-10-12 | Pharmaceutical compositions endowed with an anti-bacterial activity and their use in the treatment of infections due to gram-positive and gram-negative pathogens |
| DE2942107A DE2942107C2 (en) | 1978-10-20 | 1979-10-18 | Pharmaceutical preparation with an antibacterial effect and its use for the treatment of infections caused by gram-positive and gram-negative pathogenic germs |
| ES485561A ES485561A0 (en) | 1978-10-20 | 1979-10-19 | PROCEDURE FOR OBTAINING PHARMACEUTICAL COMPOSITIONS OF ANTIBACTERIAL ACTIVITY |
| FR7926095A FR2439015A1 (en) | 1978-10-20 | 1979-10-19 | PHARMACEUTICAL COMPOSITIONS CONSTITUTED BY AN ANTIBIOTIC ASSOCIATED WITH A HETEROCYCLIC B-KETOACID |
| PT70347A PT70347A (en) | 1978-10-20 | 1979-10-19 | PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION WITH ANTIBACTERIAL AND THERAPEUTIC ACTIVITY FOR INFECTIONS CAUSED BY GRAM-POSITIVE AND GRAM-NEGATIVE GERMS |
| GB7936548A GB2035800B (en) | 1978-10-20 | 1979-10-22 | Pharmaceutical compositions containing anantibiotic and a beta ketoacid |
| US06/238,811 US4386070A (en) | 1978-10-20 | 1981-02-27 | Pharmaceutical compositions endowed with an antibacterial activity and their use in the treatment of infections due to gram-positive and gram-negative pathogens |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT25973/79A IT1123321B (en) | 1979-09-25 | 1979-09-25 | Synergistic antibiotic compsns. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7925973A0 IT7925973A0 (en) | 1979-09-25 |
| IT1123321B true IT1123321B (en) | 1986-04-30 |
Family
ID=11218308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT25973/79A IT1123321B (en) | 1978-10-20 | 1979-09-25 | Synergistic antibiotic compsns. |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1123321B (en) |
-
1979
- 1979-09-25 IT IT25973/79A patent/IT1123321B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| IT7925973A0 (en) | 1979-09-25 |
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