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IT1190891B - METHOD FOR SOLID PHASE SYNTHESIS OF RETROINVERTED POLYPEPTIDES - Google Patents

METHOD FOR SOLID PHASE SYNTHESIS OF RETROINVERTED POLYPEPTIDES

Info

Publication number
IT1190891B
IT1190891B IT22046/82A IT2204682A IT1190891B IT 1190891 B IT1190891 B IT 1190891B IT 22046/82 A IT22046/82 A IT 22046/82A IT 2204682 A IT2204682 A IT 2204682A IT 1190891 B IT1190891 B IT 1190891B
Authority
IT
Italy
Prior art keywords
phase synthesis
polypeptides
bis
retroinverted
solid phase
Prior art date
Application number
IT22046/82A
Other languages
Italian (it)
Other versions
IT8222046A0 (en
Inventor
Antonello Pessi
Massimo Pinori
Antonio Silvio Verdini
Giuseppe Claudio Viscomi
Original Assignee
Anic Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anic Spa filed Critical Anic Spa
Priority to IT22046/82A priority Critical patent/IT1190891B/en
Publication of IT8222046A0 publication Critical patent/IT8222046A0/en
Priority to AT83200889T priority patent/ATE30033T1/en
Priority to EP83200889A priority patent/EP0097994B1/en
Priority to DE8383200889T priority patent/DE3373908D1/en
Application granted granted Critical
Publication of IT1190891B publication Critical patent/IT1190891B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention relates to a method for the solid-phase synthesis of polypeptides containing retro-inverted peptide bonds, using polydimethylacrylamide-co-acryloylsarcosimethylester resin cross-linked with N, N min -ethylene-bis-acrylamide as the insoluble support for lengthening the polypeptide chain in stages by the addition of suitable amino acid derivatives and/or peptides in succession. In particular, the method described in the present invention allows the easy preparation, on the polymer matrix, of monoacylated gem-diamino residues using the reagent I, I-bis (trifluoroacetoxy) iodobenzene in mixed aqueous-organic solvents.
IT22046/82A 1982-06-24 1982-06-24 METHOD FOR SOLID PHASE SYNTHESIS OF RETROINVERTED POLYPEPTIDES IT1190891B (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT22046/82A IT1190891B (en) 1982-06-24 1982-06-24 METHOD FOR SOLID PHASE SYNTHESIS OF RETROINVERTED POLYPEPTIDES
AT83200889T ATE30033T1 (en) 1982-06-24 1983-06-17 PROCESS FOR PRODUCTION OF RETRO-INVERSO SOLID PHASE POLYPEPTIDES.
EP83200889A EP0097994B1 (en) 1982-06-24 1983-06-17 Method for the solid-phase synthesis of retro-inverso polypeptides
DE8383200889T DE3373908D1 (en) 1982-06-24 1983-06-17 Method for the solid-phase synthesis of retro-inverso polypeptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22046/82A IT1190891B (en) 1982-06-24 1982-06-24 METHOD FOR SOLID PHASE SYNTHESIS OF RETROINVERTED POLYPEPTIDES

Publications (2)

Publication Number Publication Date
IT8222046A0 IT8222046A0 (en) 1982-06-24
IT1190891B true IT1190891B (en) 1988-02-24

Family

ID=11190672

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22046/82A IT1190891B (en) 1982-06-24 1982-06-24 METHOD FOR SOLID PHASE SYNTHESIS OF RETROINVERTED POLYPEPTIDES

Country Status (4)

Country Link
EP (1) EP0097994B1 (en)
AT (1) ATE30033T1 (en)
DE (1) DE3373908D1 (en)
IT (1) IT1190891B (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI843837L (en) * 1983-02-07 1984-09-28 Ferring Ab ENZYMINHIBITORER.
IT1164225B (en) * 1983-05-13 1987-04-08 Anic Spa INVERTED ANALOGS OF PENTAPEPTIDE ENHANCING BRADICHINA BPP5A AND METHODS FOR THEIR PREPARATION
IT1164239B (en) * 1983-05-25 1987-04-08 Anic Spa A RETRO-REVERSE ANALOG OF THE DECAPEPTIDE (5-14) OF THE EQUINE ANGIOTENSINOGEN SPECIFIC INHIBITOR OF RENINE WITH HIGH RESISTANCE TO ENZYMATIC HYDROLYSIS
IT1164240B (en) * 1983-05-25 1987-04-08 Anic Spa New equine angiotensinogen 5-14 deca-peptide retro-inverted analogue
US4668476A (en) * 1984-03-23 1987-05-26 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
IT1178789B (en) * 1984-12-21 1987-09-16 Assorenti REVERSE-INVERTED PEPTIDES ANALOGS OF BRADICHININE BPP 5A POTENTIATOR
IT1178786B (en) * 1984-12-21 1987-09-16 Assorenti PARTIALLY MODIFIED BACK-REVERSE ANALOGS OF NEUROTENSIN
IT1184317B (en) * 1985-02-05 1987-10-28 Eniricerche Spa BACK-REVERSE ANALOGS OF PEPTIDE POTENTIAL OF BRADICHINA BPP5A
IT1190389B (en) * 1985-09-19 1988-02-16 Eniricerche Spa HEXOTEPTIDES WITH HYPOTENSIVE ACTIVITY
IT1188206B (en) * 1985-11-28 1988-01-07 Eniricerche Spa PROCEDURE FOR THE SOLID-PHASE SYNTHESIS OF PEPTIDES IN WHICH AT LEAST ONE AMID LINK IS INVERTED
GB2187461A (en) * 1986-02-03 1987-09-09 Medical Res Council Monitoring method for the synthesis of a linear of amino acid residues
DE3783280T2 (en) * 1986-07-16 1993-05-06 Eniricerche Spa PARTIAL RETRO-INVERTED ANALOGS OF TUFTSIN, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE IT.
IT1196500B (en) * 1986-07-16 1988-11-16 Eniricerche Spa MALONIC ACID DERIVATIVES AND METHODS FOR THEIR SYNTHESIS
US6261569B1 (en) 1992-08-27 2001-07-17 Deakin Research Limited Retro-, inverso- and retro-inverso synthetic peptide analogues
FR2717081B1 (en) * 1994-03-14 1996-06-21 Centre Nat Rech Scient Retropeptides, antibodies to the latter, and their uses for vaccination and in vitro diagnosis.
US6916904B2 (en) 2002-04-24 2005-07-12 Zolaris Biosciences, Llc Inhibition of immune complex formation
EP1730170B1 (en) 2004-03-10 2020-02-19 Trinity Therapeutics, Inc. Method for inhibiting immune complex formation in a subject
WO2008124768A1 (en) 2007-04-09 2008-10-16 The General Hospital Corporation Hemojuvelin fusion proteins and uses thereof
TWI541020B (en) 2008-04-17 2016-07-11 巴克斯歐塔公司 Biologically active peptide
WO2010009380A2 (en) 2008-07-18 2010-01-21 Trinity Therapeutics, Inc. Methods for treating immune-mediated dengue fever infections and antibody-dependent enhancement of dengue fever infections, including dengue hemorrhagic fever and dengue shock syndrome
EP3406267A1 (en) 2011-03-25 2018-11-28 Children's Medical Center Corporation Lin28-mediated control of let-7 biogenesis
PL2717898T3 (en) 2011-06-10 2019-06-28 Bioverativ Therapeutics Inc. Pro-coagulant compounds and methods of use thereof
AU2013208293B2 (en) 2012-01-09 2017-08-10 Serpin Pharma, Llc Peptides and methods of using same
ES2651113T3 (en) 2012-06-25 2018-01-24 The Brigham And Women's Hospital, Inc. Targeted therapeutic treatments
KR20160029731A (en) 2013-03-12 2016-03-15 더 제너럴 하스피탈 코포레이션 Modified mullerian inhibiting substance(mis) proteins and uses thereof for the treatment of diseases
WO2015070014A1 (en) 2013-11-08 2015-05-14 Biogen Idec Ma Inc. Procoagulant fusion compound
WO2016044707A1 (en) 2014-09-18 2016-03-24 Cedars-Sinai Medical Center Compositions and methods for treating fibrosis
EP4194001A1 (en) 2015-04-22 2023-06-14 Cedars-Sinai Medical Center Enterically delivered bitter oligopeptides for the treatment for type 2 diabetes and obesity
CN113429455B (en) 2015-08-28 2024-11-22 赛品制药有限责任公司 Methods for treating diseases
WO2017075451A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
WO2017075465A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
EP3368689B1 (en) 2015-10-28 2020-06-17 The Broad Institute, Inc. Composition for modulating immune responses by use of immune cell gene signature
US20190262399A1 (en) 2016-09-07 2019-08-29 The Broad Institute, Inc. Compositions and methods for evaluating and modulating immune responses
CN121159628A (en) 2018-09-10 2025-12-19 莱恩治疗公司 Modified peptide fragments of CAV-1 protein and their use in the treatment of fibrosis
BR112021004420A2 (en) 2018-09-10 2021-06-01 Board Of Regents, The University Of Texas System dry powder formulation of caveolin-1 peptides and methods of use thereof
EP3937966A4 (en) 2019-03-11 2022-11-30 Lung Therapeutics, Inc. COMPOSITIONS AND METHODS FOR PROTECTING ALVEOLAR EPITHELIAL CELLS TYPE 2 (AEC2)
WO2023200887A1 (en) 2022-04-13 2023-10-19 Paradigm Immunotherapeutics, Inc. Methods of preventing or treating infection by respiratory viruses including sars-cov-2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862114A (en) * 1971-11-22 1975-01-21 Ici Australia Ltd Analogs of substance p

Also Published As

Publication number Publication date
EP0097994A2 (en) 1984-01-11
DE3373908D1 (en) 1987-11-05
ATE30033T1 (en) 1987-10-15
EP0097994B1 (en) 1987-09-30
EP0097994A3 (en) 1985-11-27
IT8222046A0 (en) 1982-06-24

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