[go: up one dir, main page]

IT1157001B - 2 AMINO ACIDS (3 HALOGENOBENZOIL) METHYLPHENYLACETICS THEIR ESTERS AND PHARMACEUTICAL SALTS AND COMPOSITIONS CONTAINING SUCH COMPOUNDS - Google Patents

2 AMINO ACIDS (3 HALOGENOBENZOIL) METHYLPHENYLACETICS THEIR ESTERS AND PHARMACEUTICAL SALTS AND COMPOSITIONS CONTAINING SUCH COMPOUNDS

Info

Publication number
IT1157001B
IT1157001B IT67152/82A IT6715282A IT1157001B IT 1157001 B IT1157001 B IT 1157001B IT 67152/82 A IT67152/82 A IT 67152/82A IT 6715282 A IT6715282 A IT 6715282A IT 1157001 B IT1157001 B IT 1157001B
Authority
IT
Italy
Prior art keywords
methylphenylacetics
halogenobenzoil
esters
compounds
amino acids
Prior art date
Application number
IT67152/82A
Other languages
Italian (it)
Other versions
IT8267152A0 (en
Inventor
David Allan Walsh
Dwight Allen Shamblee
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of IT8267152A0 publication Critical patent/IT8267152A0/en
Application granted granted Critical
Publication of IT1157001B publication Critical patent/IT1157001B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32Phenylacetic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
IT67152/82A 1981-02-17 1982-02-10 2 AMINO ACIDS (3 HALOGENOBENZOIL) METHYLPHENYLACETICS THEIR ESTERS AND PHARMACEUTICAL SALTS AND COMPOSITIONS CONTAINING SUCH COMPOUNDS IT1157001B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23453181A 1981-02-17 1981-02-17

Publications (2)

Publication Number Publication Date
IT8267152A0 IT8267152A0 (en) 1982-02-10
IT1157001B true IT1157001B (en) 1987-02-11

Family

ID=22881752

Family Applications (1)

Application Number Title Priority Date Filing Date
IT67152/82A IT1157001B (en) 1981-02-17 1982-02-10 2 AMINO ACIDS (3 HALOGENOBENZOIL) METHYLPHENYLACETICS THEIR ESTERS AND PHARMACEUTICAL SALTS AND COMPOSITIONS CONTAINING SUCH COMPOUNDS

Country Status (32)

Country Link
JP (1) JPS57149256A (en)
KR (1) KR880002289B1 (en)
AT (1) AT387213B (en)
AU (1) AU7950382A (en)
BE (1) BE892156A (en)
CA (1) CA1173852A (en)
CH (1) CH651294A5 (en)
DE (1) DE3204854C2 (en)
DK (1) DK155936C (en)
EG (1) EG15798A (en)
ES (1) ES509622A0 (en)
FI (1) FI73970C (en)
FR (1) FR2499981B1 (en)
GB (1) GB2093027B (en)
GR (1) GR76516B (en)
HK (1) HK90384A (en)
HU (1) HU187644B (en)
IE (1) IE52289B1 (en)
IL (1) IL64724A0 (en)
IT (1) IT1157001B (en)
KE (1) KE3454A (en)
LU (1) LU83928A1 (en)
MY (1) MY8500908A (en)
NL (1) NL8200607A (en)
NO (1) NO160133C (en)
NZ (1) NZ199745A (en)
PL (1) PL139815B1 (en)
PT (1) PT74441B (en)
SE (1) SE453387B (en)
SG (1) SG68584G (en)
YU (1) YU44333B (en)
ZA (1) ZA82697B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683242A (en) * 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
US5475034A (en) * 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
BR9600975A (en) * 1996-03-11 1997-12-30 Fundacao Oswaldo Cruz Derivatives of gem-difluorphenylacetic acid and gem-difluorphenylacetamide process of their preparation and their pharmaceutical applications
US6034266A (en) * 1996-03-11 2000-03-07 Fundacao Oswaldo Cruz-Fiocruz Gem-difluoro derivative of phenylacetamide and phenylacetic acid and their pharmaceutical uses
AR030346A1 (en) * 2000-08-14 2003-08-20 Alcon Inc METHOD OF TREATMENT OF NEURODEGENERATIVE DISORDERS OF THE RETINA AND HEAD OF OPTICAL NERVE
AR030345A1 (en) * 2000-08-14 2003-08-20 Alcon Inc METHOD OF TREATMENT OF DISORDERS RELATED TO ANGIOGENESIS
US6646003B2 (en) 2001-04-02 2003-11-11 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders of the posterior segment of the eye using an amide derivative of flurbiprofen or ketorolac
TWI358290B (en) 2004-12-02 2012-02-21 Alcon Inc Topical nepafenac formulations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (en) * 1967-07-31 1971-03-24
US3997368A (en) * 1975-06-24 1976-12-14 Bell Telephone Laboratories, Incorporated Elimination of stacking faults in silicon devices: a gettering process
CH577461A5 (en) * 1975-08-13 1976-07-15 Robins Co Inc A H
FR2366015A1 (en) * 1975-11-05 1978-04-28 Robins Co Inc A H Amino-benzoyl-phenylacetic acid derivs - antiinflammatory, hypocholesterolemic and blood platelet agglomeration inhibitory activity
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CH651294A5 (en) 1985-09-13
ATA43382A (en) 1988-05-15
SG68584G (en) 1985-03-15
IE820310L (en) 1982-08-17
ZA82697B (en) 1983-01-26
KE3454A (en) 1984-10-12
AT387213B (en) 1988-12-27
SE453387B (en) 1988-02-01
DK155936B (en) 1989-06-05
PT74441A (en) 1982-03-01
IE52289B1 (en) 1987-09-02
YU32582A (en) 1985-06-30
BE892156A (en) 1982-06-16
FR2499981B1 (en) 1986-05-23
ES8301895A1 (en) 1982-12-16
EG15798A (en) 1986-06-30
GB2093027A (en) 1982-08-25
JPH0365338B2 (en) 1991-10-11
DK155936C (en) 1989-11-06
DE3204854C2 (en) 1994-06-16
ES509622A0 (en) 1982-12-16
SE8200891L (en) 1982-08-18
NZ199745A (en) 1985-07-12
NO160133C (en) 1989-03-15
FI73970C (en) 1987-12-10
MY8500908A (en) 1985-12-31
LU83928A1 (en) 1983-06-07
PL235095A1 (en) 1982-11-08
HU187644B (en) 1986-02-28
IL64724A0 (en) 1982-03-31
FR2499981A1 (en) 1982-08-20
GB2093027B (en) 1984-07-04
KR830008990A (en) 1983-12-16
KR880002289B1 (en) 1988-10-22
YU44333B (en) 1990-06-30
DK67382A (en) 1982-08-18
CA1173852A (en) 1984-09-04
GR76516B (en) 1984-08-10
JPS57149256A (en) 1982-09-14
NO160133B (en) 1988-12-05
PT74441B (en) 1983-08-24
NO820468L (en) 1982-08-18
DE3204854A1 (en) 1982-09-09
IT8267152A0 (en) 1982-02-10
HK90384A (en) 1984-11-23
FI73970B (en) 1987-08-31
PL139815B1 (en) 1987-02-28
NL8200607A (en) 1982-09-16
AU7950382A (en) 1982-08-26
FI820392L (en) 1982-08-18

Similar Documents

Publication Publication Date Title
IT1133079B (en) 4 AMINO ACIDS & QUINOLINCARBOSSILS AND THEIR ESTERS PARTICULARLY USEFUL AS ANTI-SECRETIVE AND ANTI-ULCER
FR2342271A1 (en) PERFECTED PROCESS AND APPARATUS FOR THE PREPARATION OF AROMATIC DICARBOXYLIC ACIDS
IT1157001B (en) 2 AMINO ACIDS (3 HALOGENOBENZOIL) METHYLPHENYLACETICS THEIR ESTERS AND PHARMACEUTICAL SALTS AND COMPOSITIONS CONTAINING SUCH COMPOUNDS
IT1139455B (en) PROCESS FOR THE PREPARATION OF ALPHA-ARYLPROPIONIC ACIDS AND THEIR ALKALINE SALTS
PT88634A (en) A PROCESS FOR THE PREPARATION OF CATECHOL CARBOXYLIC ACID DERIVATIVES AND OF PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
IT7968724A0 (en) PROCEDURE FOR THE PREPARATION OF DIOXIN-FREE TRICHLOROPHENOXYLIC ACIDS 2 4 5
PT86776A (en) PROCESS FOR THE PREPARATION OF PIPERAZINECARBOXYLIC ACID AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
IT1206156B (en) PREPARATION OF CARBOXYLIC ACIDS
IT1154663B (en) PROCEDURE FOR THE RESOLUTION IN OPTICAL ANTIPODS OF MIXTURES OF D- AND L-2- (6-METHOXY-2-NAFTIL) -PROPIONIC ACIDS
IT8048995A0 (en) PROCEDURE FOR THE PREPARATION OF ALKANOIC ACIDS
IT1132273B (en) ACIDS 2 AMINO 3 (ALCHYLTHIOBENZOIL) -PHENYLACETICS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH ACIDS
IT1205284B (en) PROCEDURE FOR THE PREPARATION OF ESTERS OR SALTS OF AROMATIC OR HETEROAROMATIC ACIDS
IT1189244B (en) COMPOUNDS OF 1 (2H) -ISOKINOLONE AND THEIR ADDITION SALTS WITH ACIDS
IT1134999B (en) PROCEDURE FOR PREPARING ALCHYL ESTERS OF C-ALCHYL-TARTRONIC OR C-HALOGEN-ALKYL-TARTRONIC ACIDS
IT1170545B (en) PROCEDURE FOR THE PRODUCTION OF AMINOCYCLOPENTANOIC ACIDS
IT1122746B (en) PERFECTED PROCEDURE FOR THE PREPARATION OF 4 (5) -HYDROXYMETHYL-5 (4) -ALKYLIN-LOWER -IMIDAZOLS AND THEIR ADDITION SALTS WITH ACIDS
IT1081300B (en) PROCESS FOR THE PREPARATION OF SALTS FROM DICARBOXYLIC ACIDS AND FROM DIAMINE
IT1162861B (en) MERCAPTOTETRAZOLYLALKANOHYDROXAMIC ACIDS AND PROCEDURE FOR THEIR PREPARATION
IT8347835A0 (en) HERBICIDE COMPOSITION BASED ON PHENOXYPHENOXYPROPIONIC ACIDS ESTERS
IT1121020B (en) DIARYL ACID ESTERS 2 2 CYCLOPROPAN CARBOXYLIC PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS INCLUDING SUCH ESTERS
FR2511677B1 (en) PROCESS FOR THE PREPARATION OF ESTERS OF ALCOXYVINCAMINIC ACIDS AND ALCOXYAPOVINCAMINIC ACIDS
IT1188988B (en) COMPOUNDS 1 (2H) -ISOKINOLONICS AND THEIR ADDITION SALTS WITH ACIDS
IT8347773A0 (en) HERBICIDE COMPOSITION BASED ON HETEROCICLIC ESTERS OF PHENOXYBENZOIC ACIDS
IT7941020A0 (en) ACIDS 2
IT8019878A0 (en) ESTERS OF ARYLPROPILONIC ACIDS ANTI-INFLAMMATORY SUITABILITY, PROCESS FOR THEIR PREPARATION, AND RELATED PHARMACEUTICAL COMPOSITIONS.

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950131