IT1143922B - 4-AROILIMIDAZOL-2-ONI EQUIPPED WITH CARDIOTONIC AND ANTI-THROMBOTIC ANTI-HYPERTENSIVE PROPERTIES AND PROCEDURE FOR THEIR PREPARATION - Google Patents

4-AROILIMIDAZOL-2-ONI EQUIPPED WITH CARDIOTONIC AND ANTI-THROMBOTIC ANTI-HYPERTENSIVE PROPERTIES AND PROCEDURE FOR THEIR PREPARATION

Info

Publication number: IT1143922B
Authority: IT; Italy
Prior art keywords: aroilimidazol; oni; cardiotonic; thrombotic; procedure
Prior art date: 1979-06-18

Application number

IT48997/80A

Other languages

Italian (it)

Other versions

IT8048997A0 (en

Inventor

Richard A Schnettler

Richard C Dage

J Martin Grisar

Original Assignee

Richardson Merrell Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-06-18

Filing date

1980-06-17

Publication date

1986-10-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26727558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1143922(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1980-06-17 Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc

1980-06-17 Publication of IT8048997A0 publication Critical patent/IT8048997A0/en

1986-10-29 Application granted granted Critical

1986-10-29 Publication of IT1143922B publication Critical patent/IT1143922B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IT48997/80A 1979-06-18 1980-06-17 4-AROILIMIDAZOL-2-ONI EQUIPPED WITH CARDIOTONIC AND ANTI-THROMBOTIC ANTI-HYPERTENSIVE PROPERTIES AND PROCEDURE FOR THEIR PREPARATION IT1143922B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4980879A	1979-06-18	1979-06-18
US11920780A	1980-02-07	1980-02-07

Publications (2)

Publication Number	Publication Date
IT8048997A0 IT8048997A0 (en)	1980-06-17
IT1143922B true IT1143922B (en)	1986-10-29

Family

ID=26727558

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT48997/80A IT1143922B (en)	1979-06-18	1980-06-17	4-AROILIMIDAZOL-2-ONI EQUIPPED WITH CARDIOTONIC AND ANTI-THROMBOTIC ANTI-HYPERTENSIVE PROPERTIES AND PROCEDURE FOR THEIR PREPARATION

Country Status (20)

Country	Link
AT (1)	AT375349B (en)
AU (1)	AU532783B2 (en)
CA (1)	CA1132554A (en)
CH (1)	CH646155A5 (en)
DE (1)	DE3021792A1 (en)
DK (1)	DK160269C (en)
ES (1)	ES492255A0 (en)
FR (1)	FR2459233A1 (en)
GB (1)	GB2055364B (en)
HK (1)	HK61486A (en)
HU (1)	HU186736B (en)
IE (1)	IE50646B1 (en)
IL (1)	IL60243A (en)
IT (1)	IT1143922B (en)
MY (1)	MY8600709A (en)
NL (2)	NL193752C (en)
NO (1)	NO152841C (en)
NZ (1)	NZ193935A (en)
PH (1)	PH18683A (en)
SE (2)	SE447107B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH18106A (en) *	1981-02-18	1985-03-21	Merrell Dow Pharma	Novel-4-aroylimidazol-2-ones
US4405628A (en) *	1981-03-05	1983-09-20	Merrell Dow Pharmaceuticals Inc.	4-Pyridylimidazolones and method of use
US4329470A (en)	1981-05-04	1982-05-11	Merrell Dow Pharmaceuticals Inc.	5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4329471A (en) *	1981-05-04	1982-05-11	Merrell Dow Pharmaceuticals Inc.	4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4526981A (en) *	1981-05-04	1985-07-02	Merrell Dow Pharmaceuticals Inc.	[1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates
US4381393A (en) *	1981-05-04	1983-04-26	Merrell Dow Pharmaceuticals Inc.	4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
JPS57185266A (en) *	1981-05-04	1982-11-15	Merrell Dow Pharma	4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazole- 2-one
US4371737A (en) *	1981-05-04	1983-02-01	Merrell Dow Pharmaceuticals Inc.	5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4367236A (en)	1981-11-04	1983-01-04	Merrell Dow Pharmaceuticals Inc.	Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4410540A (en) *	1981-11-04	1983-10-18	Merrell Dow Pharmaceuticals Inc.	Cardiotonic 4-aroylimidazolidin-2-ones
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
CA2560528A1 (en) *	2004-03-22	2005-10-06	Myogen, Inc.	(s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
WO2005092333A1 (en) *	2004-03-22	2005-10-06	Myogen, Inc.	(r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
EP2218442A1 (en)	2005-11-09	2010-08-18	CombinatoRx, Inc.	Methods, compositions, and kits for the treatment of ophthalmic disorders
WO2008151257A2 (en)	2007-06-04	2008-12-11	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009149279A2 (en)	2008-06-04	2009-12-10	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en)	2008-07-16	2019-09-24	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
KR102034748B1 (en)	2011-03-01	2019-10-21	시너지 파마슈티컬즈 인코포레이티드	Process of preparing guanylate cyclase c agonists
EP2804603A1 (en)	2012-01-10	2014-11-26	President and Fellows of Harvard College	Beta-cell replication promoting compounds and methods of their use
US9545446B2 (en)	2013-02-25	2017-01-17	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
EP2970384A1 (en)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
WO2014151200A2 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
AU2014274812B2 (en)	2013-06-05	2018-09-27	Bausch Health Ireland Limited	Ultra-pure agonists of guanylate cyclase C, method of making and using same
WO2015021358A2 (en)	2013-08-09	2015-02-12	Dominique Charmot	Compounds and methods for inhibiting phosphate transport
CN114340631A (en)	2019-05-21	2022-04-12	阿德利克斯股份有限公司	Combination for reducing serum phosphate in a patient
CN114539157B (en) *	2022-03-03	2023-12-22	曲靖师范学院	Method for preparing 4-iodo-N-aryl pyrazole compound by iodine-promoted oxidation method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2441933A (en) *	1945-07-30	1948-05-18	Hoffmann La Roche	Substituted imidazolones and process of making them

1980
- 1980-06-04 NZ NZ193935A patent/NZ193935A/en unknown
- 1980-06-05 IE IE1162/80A patent/IE50646B1/en not_active IP Right Cessation
- 1980-06-06 SE SE8004253A patent/SE447107B/en not_active IP Right Cessation
- 1980-06-06 IL IL60243A patent/IL60243A/en unknown
- 1980-06-06 AU AU59118/80A patent/AU532783B2/en not_active Expired
- 1980-06-09 ES ES492255A patent/ES492255A0/en active Granted
- 1980-06-11 DE DE19803021792 patent/DE3021792A1/en active Granted
- 1980-06-13 AT AT0314280A patent/AT375349B/en not_active IP Right Cessation
- 1980-06-16 CH CH462780A patent/CH646155A5/en not_active IP Right Cessation
- 1980-06-16 PH PH24143A patent/PH18683A/en unknown
- 1980-06-17 DK DK259080A patent/DK160269C/en not_active IP Right Cessation
- 1980-06-17 NL NL8003498A patent/NL193752C/en not_active IP Right Cessation
- 1980-06-17 CA CA354,197A patent/CA1132554A/en not_active Expired
- 1980-06-17 HU HU801506A patent/HU186736B/en unknown
- 1980-06-17 NO NO801796A patent/NO152841C/en unknown
- 1980-06-17 FR FR8013434A patent/FR2459233A1/en active Granted
- 1980-06-17 IT IT48997/80A patent/IT1143922B/en active Protection Beyond IP Right Term
- 1980-06-18 GB GB8019898A patent/GB2055364B/en not_active Expired
1985
- 1985-03-25 SE SE8501452A patent/SE464559B/en not_active IP Right Cessation
1986
- 1986-08-21 HK HK614/86A patent/HK61486A/en not_active IP Right Cessation
- 1986-12-30 MY MY709/86A patent/MY8600709A/en unknown
2000
- 2000-09-04 NL NL300015C patent/NL300015I1/en unknown

Also Published As

Publication number	Publication date
SE8004253L (en)	1980-12-19
GB2055364B (en)	1983-06-08
NL300015I1 (en)	2000-11-01
CH646155A5 (en)	1984-11-15
IL60243A (en)	1987-01-30
NZ193935A (en)	1985-05-31
ES8105299A1 (en)	1981-06-01
SE8501452L (en)	1985-03-25
NO152841C (en)	1985-11-27
DK160269C (en)	1991-07-22
GB2055364A (en)	1981-03-04
AU532783B2 (en)	1983-10-13
IE801162L (en)	1980-12-18
NO152841B (en)	1985-08-19
ATA314280A (en)	1983-12-15
NL193752C (en)	2000-09-04
DK160269B (en)	1991-02-18
NO801796L (en)	1980-12-19
NL8003498A (en)	1980-12-22
FR2459233A1 (en)	1981-01-09
MY8600709A (en)	1986-12-31
NL300015I2 (en)	2000-10-02
HK61486A (en)	1986-08-29
IT8048997A0 (en)	1980-06-17
DE3021792C2 (en)	1989-08-10
SE8501452D0 (en)	1985-03-25
IL60243A0 (en)	1980-09-16
SE464559B (en)	1991-05-13
PH18683A (en)	1985-08-29
HU186736B (en)	1985-09-30
NL193752B (en)	2000-05-01
AU5911880A (en)	1981-01-08
DE3021792A1 (en)	1981-01-22
DK259080A (en)	1980-12-19
SE447107B (en)	1986-10-27
ES492255A0 (en)	1981-06-01
AT375349B (en)	1984-07-25
IE50646B1 (en)	1986-06-11
FR2459233B1 (en)	1983-09-23
CA1132554A (en)	1982-09-28

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Legal Events

Date	Code	Title	Description
1992-04-24	ITCP	Complementary protection certificate	Free format text: CCP 156
1992-11-13	MEDD	Supplementary protection certificate for pharmaceutical products: granted	Free format text: CCP 156, 19920424; MERREL DOW PHARMACEUTICALS INC.
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19950419