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IT1064067B - 17 Alpha, 21-dihydroxy-steroid 17-monoesters prepn. - by 17-esterifying 21-phosphates and enzymatically dephosphorylating - Google Patents

17 Alpha, 21-dihydroxy-steroid 17-monoesters prepn. - by 17-esterifying 21-phosphates and enzymatically dephosphorylating

Info

Publication number
IT1064067B
IT1064067B IT1905974A IT1905974A IT1064067B IT 1064067 B IT1064067 B IT 1064067B IT 1905974 A IT1905974 A IT 1905974A IT 1905974 A IT1905974 A IT 1905974A IT 1064067 B IT1064067 B IT 1064067B
Authority
IT
Italy
Prior art keywords
dihydroxy
17alpha
esterifying
monoesters
steroid
Prior art date
Application number
IT1905974A
Other languages
Italian (it)
Inventor
Ercoli Alberto
Da Col Marco
Original Assignee
Lark Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lark Spa filed Critical Lark Spa
Priority to IT1905974A priority Critical patent/IT1064067B/en
Priority to FI1892/74A priority patent/FI189274A7/fi
Priority to SE7407989A priority patent/SE408898B/en
Priority to NL7408524A priority patent/NL7408524A/en
Priority to AU70507/74A priority patent/AU7050774A/en
Priority to DK342774A priority patent/DK132661C/en
Priority to JP49073462A priority patent/JPS5096558A/ja
Priority to IL45142A priority patent/IL45142A0/en
Priority to CA203,680A priority patent/CA1034521A/en
Priority to DE2431377A priority patent/DE2431377A1/en
Priority to GB2754374A priority patent/GB1461663A/en
Priority to CH1167474A priority patent/CH606096A5/xx
Priority to NL7416691A priority patent/NL7416691A/en
Priority to FR7442886A priority patent/FR2256926B1/fr
Priority to JP49149059A priority patent/JPS5096559A/ja
Priority to FR7443060A priority patent/FR2256763A1/fr
Priority to DE19742461512 priority patent/DE2461512A1/en
Priority to DK689774A priority patent/DK689774A/da
Application granted granted Critical
Publication of IT1064067B publication Critical patent/IT1064067B/en

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

17-Monoesters of 17alpha, 21-dihydroxy-steroids, e.g., prednisone 17-formate, are prepd. by (a) esterifying the corresp. 17alpha, 21-dihydroxy-steroid 21-phosphate with suitable acylating agent under very mild conditions so that only the 17alpha-hydroxy gp. is directly esterified and (b) subsequently sephosphorylating the resulting 17alpha-acyloxy-21-phosphate by enzymatic hydrolysis with an acid phosphatase at regulated pH. Certain specified prodts. are new and claimed cpds. Under the mild conditions employed, substantially complete 17-acylation can be achieved without affecting any other OH gps. which may be present in the molecule. the 21-dephosphorylation is highly selective.
IT1905974A 1974-01-04 1974-01-04 17 Alpha, 21-dihydroxy-steroid 17-monoesters prepn. - by 17-esterifying 21-phosphates and enzymatically dephosphorylating IT1064067B (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT1905974A IT1064067B (en) 1974-01-04 1974-01-04 17 Alpha, 21-dihydroxy-steroid 17-monoesters prepn. - by 17-esterifying 21-phosphates and enzymatically dephosphorylating
FI1892/74A FI189274A7 (en) 1974-01-04 1974-06-20
SE7407989A SE408898B (en) 1974-01-04 1974-06-24 PROCEDURE FOR THE PREPARATION OF A 17-MONOESTER OF 17ALFA, 21-DIHYDROXISTEROIDS
NL7408524A NL7408524A (en) 1974-01-04 1974-06-25 PROCESS FOR PREPARING 17-ACYLESTERS 7(ALPHA),21-DIHYDROXYSTEROIDES OF THE PREGNAN- .
DK342774A DK132661C (en) 1974-01-04 1974-06-26 PROCEDURE FOR THE PREPARATION OF 17-ACYLESTERS OF 17ALFA, 21-DIHYDROXYSTEROIDS OF THE PREGNAN RANGE
AU70507/74A AU7050774A (en) 1974-01-04 1974-06-26 17-acyl esters of 17a,21-dihydroxysteroids
CA203,680A CA1034521A (en) 1974-01-04 1974-06-28 PROCESS FOR THE PREPARATION OF 17-ACYL ESTERS OF 17.alpha.,21-DIHYDROXYSTEROIDS OF THE PREGNANE SERIES
IL45142A IL45142A0 (en) 1974-01-04 1974-06-28 Process for the preparation of 17-acyl esters of 17alpha,21-dihydroxysteroids of the pregnane series and new products obtained
JP49073462A JPS5096558A (en) 1974-01-04 1974-06-28
DE2431377A DE2431377A1 (en) 1974-01-04 1974-06-29 17 MONOESTERS OF 17 DELTA, 21 DIHYDROXY STEROIDS AND METHOD FOR PRODUCING THEM
GB2754374A GB1461663A (en) 1974-01-04 1974-11-12 Process for the preparation of 17-esters of 17alpha,21-dihydroxy steroids of the pregnane series and products obtained
CH1167474A CH606096A5 (en) 1974-01-04 1974-12-16
NL7416691A NL7416691A (en) 1974-01-04 1974-12-20 PROCEDURE FOR THE PREPARATION OF 17(ALPHA)-ACYLOXY-21-OXYPREGNANES, AS WELL AS PHARMACEUTICAL PRE- AND CONTAINING THESE COMPOUNDS AS ACTIVE COMMON.
FR7442886A FR2256926B1 (en) 1974-01-04 1974-12-26
JP49149059A JPS5096559A (en) 1974-01-04 1974-12-27
FR7443060A FR2256763A1 (en) 1974-01-04 1974-12-27
DE19742461512 DE2461512A1 (en) 1974-01-04 1974-12-27 21-PHOSPHATE OF 17ALPHA-ACYLOXY-21-HYDROXYPREGNANS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DK689774A DK689774A (en) 1974-01-04 1974-12-30

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1905974A IT1064067B (en) 1974-01-04 1974-01-04 17 Alpha, 21-dihydroxy-steroid 17-monoesters prepn. - by 17-esterifying 21-phosphates and enzymatically dephosphorylating

Publications (1)

Publication Number Publication Date
IT1064067B true IT1064067B (en) 1985-02-18

Family

ID=11154191

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1905974A IT1064067B (en) 1974-01-04 1974-01-04 17 Alpha, 21-dihydroxy-steroid 17-monoesters prepn. - by 17-esterifying 21-phosphates and enzymatically dephosphorylating

Country Status (1)

Country Link
IT (1) IT1064067B (en)

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